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[DOCX File]Australian Public Assessment Report for Morphine sulfate ...
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Per Dr. Ross, MS Contin should be a 12 hr medicine so dosing three times daily is a potential problem. Bring down to 2/3 dose and then if patient experiences breakthrough pain, we have better options for treating. Propose lowering conversion to 60 mg bid per Dr. Ross; he does not feel 90 to 90 is best option. Ashley will rewrite interchange.
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[DOCX File]Drug Information Common to the Class of Extended-Release ...
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PO – (MS Contin, Kadian, Avinza) – long acting. PO – (MSIR) – immediate release, short acting, used PRN for breakthrough pain in combo with MS Contin around the clock. PO solution – It comes in generic in various concentrations (10mg/5ml, 20mg/5ml or 20mg/ml) and brand name Roxanol (20mg/ml or …
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[DOC File]Pharmacy Benefits Management Services Home
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Conversion from morphine mixture to MS Contin tablets or Kapanol capsules. (See page 13) Active Morphine metabolites are . renally. excreted. Morphine should be avoided in patients with significant renal impairment. Oxycodone. a strong opioid, 50% more potent than Morphine.
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[DOCX File]AusPAR Attachment 1: Product Information for Morphine ...
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PGP inhibitors (e.g. quinidine) may increase the absorption/exposure of morphine sulfate by about two-fold. Use in Opioid-Tolerant Patients . MS Contin 100 mg and 200 mg tablet strengths are for use in opioid-tolerant patients only. Product-Specific Safety Concerns . None
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MS Contin Dosage Guide
A 33% dose reduction from the calculated dose of 100 mg is equal to 67 mg of oral morphine per day. The recommended dosing frequency of long-acting morphine (MS Contin® ) is every 12 hours (2 doses per day). MS Contin® is available in 15 mg, 30 mg, 100 mg and 200 mg controlled-release tablets.
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New Drug Review
Morphine/naltrexone should not be given more frequently than every 12 hours. Conversion from oral opioids, parenteral morphine, or other parenteral opioids to morphine/naltrexone: Parenteral to oral morphine ratio: it may take anywhere from 2 – 6 mg of oral morphine to provide analgesia equivalent to 1 mg of parenteral morphine.
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[DOC File]PAIN MANAGEMENT – ANALGESICS
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2.Most experts world-wide advocate a maximum dose of 90 mg oral morphine equivalents daily (MED) to decrease the risk of overdose and opioid-induced hyperalgesia. This does not mean doses should be escalated to this point in all patients. Many are well-controlled at lower doses. PHC recommends this 90 mg MED limit be used as a community standard.
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THE FEBRILE - NEUTROPENIC PATIENT
In the controlled clinical studies patients were followed for a median duration of 7 days. Kapanol was compared to oral morphine solution and to MS Contin using trial designs that followed the clinical and pharmacokinetic performance of each treatment in cancer patients receiving chronic opioid therapy.
ms contin equivalent to morphine

[DOC File]Equianalgesic Chart (Changes in italics)
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Crushed MS Contin® (morphine extended-release) passed through the smallest needle used (27-gauge) with a difficulty level of 1 for both the 1 mL and 5 mL samples, and up to 70% of morphine was extracted after 10 minutes.2
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[DOCX File]Primary Care & Specialist Prescribing Guidelines
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immediate release morphine in the initial dose titration, with doses of 1.0 to 2.5 mg repeated as needed every 1 to 6 h, and later conversion to a modified release formulation. One guideline noted that the initial immediate release morphine could be combined with background long …
oxycontin conversion to morphine sulfate

Ms contin conversion to morphine