Nmda receptor antagonism

    • [DOCX File]Department of Psychology - Carleton University

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      Title:Elevated lever pressing with NMDA receptor antagonism in an appetitive extinction task and resulting pERK staining in the nucleus accumbens. Year:2011. Name:Kyley Allan. Title:The role of the hippocampus in long-term memory storage and retrieval based on prior experience.

    • [DOCX File]A RANDOMIZED PHASE III TRIAL OF MEMANTINE AND WHOLE-BRAIN ...

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      Glutamate is the principle excitatory amino acid neurotransmitter in cortical and hippocampal neurons.(Orrego 1993) One of the receptors activated by glutamate is the N-methyl-D-aspartate (NMDA) receptor, which is involved in learning and memory.(Danysz 1998) Ischemia can induce excessive NMDA stimulation and lead to excitotoxicity, suggesting ...

    • [DOC File]Lippincott Williams & Wilkins

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      One study of NMDA receptor antagonism – memantine – suggests beneficial effects on core symptoms and behavior problems.84. Conclusions. Due to the small number of studies, little can be concluded definitively. There is insufficient evidence to support or refute the use of cholinesterase inhibitors or NMDA antagonists for ASD, although there ...

    • [DOC File]ECT and NMS - Ce4less

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      The serotonergic actions of the atypical APDs, especially 5-HT2A receptor antagonism, are particularly important to the differential effects of typical and atypical APDs to overcome the effects of acute or subchronic administration of N-methyl-d-aspartate (NMDA) receptor antagonists, such as phencyclidine, ketamine, and dizocipline (MK-801).

    • Comparison of the Effects of Four Pre-Bonding Preparation ...

      The analgesic action of topical diclofenac may be mediated through peripheral NMDA receptor antagonism. Pain 2009; 147(1-3): 36-45. Gage TW, Pickett FA. Mosby's Dental Drug Reference. 6th ed. USA: Mosby; 2003. p. 23, 352. Motlekar NA, Youan BB. The quest for non-invasive delivery of bioactive macromolecules: a focus on heparins.

    • [DOCX File]Ketamine for Analgesia

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      A receptor antagonism, ketamine attenuates centrally-mediated pain processes . to reduce the development. of opioid tolerance and opioid-induced hyperalgesia (1). In addition to action on NMDA recept. o. rs, k. etamine also acts as a weak opioid receptor agonist, alpha-1 and beta-2 receptor agonist, and muscarinic acetylcholine receptor ...

    • ResearchGate | Find and share research

      Antagonism at the NMDA receptor generally account for most of ketamine’s psychoactive properties (Kohrs and Durieux; 1998). The NMDA receptor is a ligand-gated ion channel that is permeable to ...

    • axsometherapeuticsinc.gcs-web.com

      Mechanisms of action of DM include NMDA receptor antagonism and sigma‑1 receptor. agonism. Altered glutamate transmission via NMDA receptors has been suggested to play a role in behavioral changes in dementia, and clinical evidence suggests that NMDA antagonism may reduce agitation and aggression in AD patients.

    • Drug-drug interactions in inpatient and outpatient ...

      It appears, that NMDA receptor antagonism by ketamine, nitrous oxide and xenon may be important for maintenance of general anesthesia and control of the central-sensitization component of postoperative pain. GABA is the major inhibitory neurotransmitter in the brain, and most of the inhibition is mediated by GABAA receptors.

    • [DOCX File]Ketamine for Analgesia

      https://info.5y1.org/nmda-receptor-antagonism_1_09d546.html

      A receptor antagonism, ketamine attenuates centrally-mediated pain processes . to reduce the development. of opioid tolerance and opioid-induced hyperalgesia (1). In addition to action on NMDA recept. o. rs, k. etamine also acts as a weak opioid receptor agonist, alpha-1 and beta-2 receptor agonist and muscarinic acetylcholine receptor ...

    • [DOCX File]SEDA-19

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      Tramadol has many reported pharmacological actions—it is a μ opioid receptor agonist, a 5HT reuptake inhibitor and releaser, a noradrenaline reuptake inhibitor, an NMDA receptor antagonist, a 5HT 2C receptor antagonist, a nicotinic acetylcholine receptor antagonist; some of these actions mediate its beneficial and adverse effects.

    • Universiteit Utrecht

      The NMDA receptor, a glutamate receptor important for synaptic plasticity, is crucially altered in expression and function after corticosterone exposure. Therefore, it could provide the link between the prenatal-stress evoked corticosterone level increase and brain deficits in the offspring.

    • [DOC File]Miami University

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      Tacrine does not alleviate rewarded alternation deficits produced by NMDA receptor antagonism. The purpose of this study was to determine if tacrine (THA), an acetylcholinesterase inhibitor used in the treatment of Alzheimer’s Disease, could alleviate spatial memory impairment produced by the NMDA receptor antagonist, MK-801.

    • [DOCX File]www.research.manchester.ac.uk

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      The NMDA receptor antagonist phencyclidine (PCP) has been widely used in the investigation and modelling of psychotic illness. Sub-chronic administration of PCP to animals can induce brain metabolic and neurochemical changes [1] as well as behaviours [2] that mimic aspects of schizophrenia.

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