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What is norepinephrine bitartrate injection?
Norepinephrine Bitartrate Injection is a concentrated, potent drug which must be diluted in dextrose containing solutions prior to infusion. An infusion of LEVOPHED should be given into a large vein (see PRECAUTIONS). Blood volume depletion should always be corrected as fully as possible before any vasopressor is administered.

How does norepinephrine affect the heart?
In relatively lower doses, the cardiac-stimulant effect of norepinephrine is predominant; with larger doses, the vasoconstrictor effect predominates.Similar to epinephrine, norepinephrine has direct agonist effects on effector cells that contain alpha- and beta-receptors.

How do you take norepinephrine?
NOTE: Norepinephrine is available commercially only as the bitartrate salt, although the dosage is expressed in terms of norepinephrine base (2 mg norepinephrine bitartrate equals 1 mg norepinephrine base). Visually inspect parenteral products for particulate matter and discoloration prior to administration. Administer by intravenous infusion.

Should norepinephrine be diluted in normal saline?
Although the manufacturer states that norepinephrine should not be diluted in normal saline (NS) alone, available data support the stability of norepinephrine in NS at concentrations up to 16 mcg/ml. The manufacturer recommends diluting 4 mg norepinephrine in 1000 ml of D5W for a concentration of 4 mcg/ml.

[PDF File]CENTER FOR DRUG EVALUATION AND RESEARCH - Food and Drug ...
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The proposed drug product, Norepinephrine Bitartrate in 5% Dextrose Injection is a ready-to-use sterile aqueous solution administered by intravenous infusion. The product is presented in following two (2) configurations: • 4 mg equivalent of norepinephrine in 250 mL of 5% dextrose: Each I mL contains the equivalent

[PDF File]ADULT CODE BLUE and RSI DRUGS - University Health System
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Norepinephrine 1 mg/ml vial Usual dose 0.1-2 mcg/kg/min Continuous infusion: Titrate to response every 2-3 min. Standard drip = 4 mg/250 ml NS (16 mcg/ml) Phenylephrine 10 mg/ml vial Initial: 0.5-3 mcg/kg/min or 50-200 mcg/min Continuous infusion: Usual maintenance dose to response every 10 minutes. Standard drip = 10 mg/250 ml NS (40 mcg/ml ...

PATIENT & CAREGIVER EDUCATION Norepinephrine
This drug may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body. What are some other side effects of this drug? All drugs may cause side effects. However, many people have no side effects

[PDF File]Norepinephrine (Levophed
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Norepinephrine (Levophed®) Moderate photophobia hypertension sinus tachycardia premature ventricular contractions (PVCs) angina dyspnea palpitations ST-T wave changes hypovolemia hypoxia Administration: NOTE: Volume depletion should always be corrected before initiation of vasopressor therapy.

[PDF File]HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not ...
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potential concerns regarding the effects of norepinephrine on the fetus. Data . Animal Data . A study in pregnant sheep receiving high doses of intravenous norepinephrine (40 mcg/min, at approximately 10 times the average maintenance dose of 2-4 mcg/min in human, on a mg/kg basis) exhibited a significant decrease in maternal placental blood flow.

[PDF File]LEVOPHED Norepinephrine Bitartrate Injection, USP Rx
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Norepinephrine Bitartrate is (-)-α-(aminomethyl)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate and has the following structural formula: LEVOPHED is supplied in sterile aqueous...

Norepinephrine drug card