Oxycodone conversion to morphine
Conversion to Oral Controlled-Release Oxycodone From Intraveno…
5. The patient’s current dose of 240 mg per day of oral oxycodone is equal to 360 mg per day of oral morphine. The methadone conversion table indicates that a conversion factor for a DOMED of 360mg equals 8.3% or a 12 to 1 ratio of morphine to methadone. The patient’s DOMED of 360 mg is equal to 30 mg of methadone daily.
[DOCX File]Date of check
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Initial dose in opioid non-tolerant patients when converting from less than 30 mg morphine equivalents, and in mild to moderate hepatic impairment - 5 mcg/hr dose. When converting from 30 mg to 80 mg morphine equivalents - first taper to 30 mg morphine equivalent, then initiate with 10 mcg/hr dose.
[DOC File]Can fentanyl patches be abused
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A common question is how to change a patient from oral morphine to a fentanyl patch. Fentanyl patches are indicated in patients with stable pain who have difficulty swallowing, unacceptable side effects with oral morphine or other opiates e.g. oxycodone; renal failure, persistent nausea and vomiting, gastrointestinal obstruction or poor compliance with oral medication
[DOC File]Jennifer P. Schneider M.D., PH.D.
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* To be used only for conversion to oral oxycodone. For patients receiving high-dose parenteral opioids, a more conservative conversion is warranted. For example, for high-dose parenteral morphine, use 1.5 instead of 3 as a multiplication factor. ... Like morphine, oxycodone is controlled under Schedule II of the Controlled Substances Act.
[DOC File]*80 mg and 160 mg for use in opioid-tolerant patients only
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Example conversion: Converting from morphine m/r 15mg bd to oral oxycodone: Total daily dose of morphine is 30mg. From Table 1, oxycodone potency equivalence = 1.5 – 2. Divide 30mg/1.5 = 20mg and 30mg/2 = 15mg. Therefore the approximate equivalent total daily dose of oral oxycodone is 15 - 20mg in divided doses.
[DOC File]Equianalgesic Chart (Changes in italics)
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Examples of dose conversion: NOTE: All drug conversions are approximate and care should be taken in conversion factors, especially at higher opioid doses. Zomorph PO to Diamorphine SC: 30mg Zomorph PO BD = 60mg Zomorph PO over 24 hours ÷ 3 = 20mg Diamorphine SC over 24 hours. Zomorph PO to Oxycodone PO:
[DOCX File]Opioids > 50 mg Morphine Equivalent Daily Dose (MEDD)
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Table 3: Results in patients with high percent urine oxymorphone Oxycodone dose qd oxymorphone (ng/ml) Oxycodone (ng/ml) %OM/OC 40 mg 916 912 99.5% 50 mg 450 324 138.9 80 mg 2,406 2,482 96.9 80 mg 4,634 4,802 96.5 240 mg 4,436 2,410 184.1 Discussion
[DOCX File]Drug Information Common to the Class of Extended-Release ...
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Morphine and Oxycodone can be used with caution if the patient is not opioid toxic. Start with small doses e.g. 2.5mg SC 4 hourly prn and titrate carefully, monitoring for toxicity. If pain is difficult to control or for dose conversion advice please seek specialist advice
[DOCX File]Nottinghamshire EPaCCS | Nottinghamshire End of Life Care ...
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Diamorphine is the opioid of choice but may not be available, in which case morphine sulphate should be prescribed. Initial starting dose is dependent on existing opioid requirements. If opioid-naïve, give diamorphine or morphine sulphate 2.5-5 mg prn subcutaneously - if patient requires > 3 prn doses over next 24 hrs, consider a syringe driver.
[DOC File]OPIOID ANALGESIA – DRUG CONVERSIONS AT KIRKWOOD …
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Patient is not opioid-tolerant, defined as taking less than or equal to 60 mg of oral morphine daily, 20 mg of oral methadone daily, 30 mg of oral oxycodone daily, 8 mg of oral hydromorphone daily, or an equianalgesic dose of another opioid, for less than one week due to intolerance.
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