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Investors/Media | Infinity Pharmaceuticals, Inc.
We believe eganelisib is the only inhibitor of PI3K-gamma currently being investigated in clinical trials. ... PD-L1 Negative Study Population: ... We combine proven scientific expertise with a passion for developing novel small molecule drugs that target disease pathways for potential applications in oncology. We are focused on advancing IPI ...
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[DOCX File]Attachment: Product Information: Pembrolizumab (rch)
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Of the 275 PD-L1 evaluable patients, 77% were PD-L1 positive (defined as membrane staining of at least 1% of neoplastic or inflammatory cells within the tumour nests). In patients previously treated with ipilimumab who were PD-L1 positive (n=118) and PD-L1 negative (n=23), the ORR in patients with measurable disease was 36% (95% CI: 27, 45) and ...
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[DOCX File]Albion College
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I wondered if I could combine both of my research experiences, so I googled “PD-1 inhibitors.” All of these drugs were big proteins, so we could not make azo versions of that. Then, I searched for “small molecule PD-1 inhibitors,” and found a plethora of molecules currently being made by Bristol-Myers Squibb that had a carbon-oxygen ...
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[DOCX File]f6publishing.blob.core.windows.net
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Immunotherapy targeting programmed death-1 (PD-1) or programmed death-ligand-1 (PD-L1) has been shown to be effective in a variety of malignancies but has poor efficacy in pancreatic ductal adenocarcinoma (PDAC). Studies have shown that PD-L1 expression in tumors is an important indicator of the efficacy of immunotherapy.
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Investor Relations | CytomX Therapeutics, Inc.
Inhibitors of the PD-L1/PD-1 pathway have been approved for the treatment of many cancers including advanced melanoma, renal cell cancer, non-small cell lung cancer, bladder cancer and liver cancer. Additionally, PD-L1 and PD-1 inhibitors have become the centerpiece of many oncology combination therapies and continue to be studied in a wide ...
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[DOCX File]Purpose of Application - Pharmaceutical Benefits Scheme ...
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BRAF inhibitor ± MEK inhibitor therapy (including dabrafenib±trametinib), followed by PD-1 inhibitors upon disease progression. For more detail on PBAC’s view, see Section 7 PBAC outcome. Comparator. The submission nominated observation (routine follow-up consisting of clinician visits and radiological imaging) as the main comparator.
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[DOCX File]Imperial college London-MRes in Translational Medicine ...
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Programmed Death Ligand 1 (PD-L1), otherwise known as B7-H1 or CD274, is the first functionally characterised ligand of the co-inhibitory Programmed Death receptor 1 (PD-1). Together with its cognate ligand PD-L2, PD-L1 plays a key role in maintaining peripheral and central immune cell tolerance through binding to the PD-1 receptor.1
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INVESTORS | TRACON Pharmaceuticals Inc
TRC102 is a small molecule inhibitor of DNA base inhibitor repair being studied in Phase 1 and Phase 2 trials sponsored by the National Cancer Institute. ... Envafolimab (KN035), a novel, single-domain antibody against PD-L1, is the first subcutaneously injected PD-(L)1 inhibitor to …
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[DOCX File]Australian Public Assessment Report for Pembrolizumab (rch)
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The authors suggested PD-L1+ melanomas are more aggressive, based on study of PD-L1+ and PD-L1- cell lines. 40% of metastatic but 14% of primary melanoma samples were PD-L1+; in 17 out of 22 patients the metastatic site was positive but the primary tumour was negative. The interpretation was that PD-L1 is expressed during disease progression.
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Calithera Biosciences, Inc. |Company Profile
The checkpoint inhibitors that block PD-L1 or PD-1 restore the ability of T-cells to utilize glucose. However, T-cells require both glucose and glutamine to proliferate. We believe that the accumulation of glutamine through the inhibition of tumor cell glutaminase has the indirect effect of supplying T-cells and NK cells with a needed nutrient.
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Pd l1 small molecule inhibitor