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[DOCX File]1570 Final PSD_Apr2020_redacted
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Given the potential for intra- and inter-observer disagreement on the PD-L1 positivity score at the ≥1% IC threshold, the ESCs considered that it may be appropriate to limit testing to once per patient, in order to prevent unnecessary re-testing of samples initially considered PD-L1 …
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[DOCX File]Summary of PICO/PPICO criteria to define the question(s ...
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The CPS measures the number of PD-L1 stained cells, including tumour cells, lymphocytes, and macrophages, divided by the total number of viable tumour cells, multiplied by 100. Despite its derivation, the CPS is expressed as a value and not a percentage, and although the result can exceed 100, the maximum score is defined as CPS …
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[DOCX File]Summary of PICO criteria to define the questions to be ...
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PASC queried whether the MBS item descriptor should specify that PD-L1 testing is to be done on the same tissue used to confirm metastases, as done in the trials (i.e. testing at recruitment). The …
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jitc.bmj.com
Biomarker testing in HNSCC Perhaps the authors could include the recent studies in circulating tumour cell (CTCs) research in HNSCC where PD‐L1 has been assessed on CTCs. Strati et al., Annals of …
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[DOCX File]Home | Cancer Discovery
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Changes in PD-L1 CPS score for 25 paired biopsies . Supplementary Figure 1. ... PDL1 CPS score at progression (primary site) B1-006. AZD6244-selumetinib. 0. stomach. stomach. 0. B1-007. AZD6244-selumetinib. 0. ... For ctDNA testing …
pdl1 composite score

[DOCX File]1457 PICO Confirmation
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However, the Application for PD-L1 testing and pembrolizumab treatment for second-line advanced/metastatic bladder cancer (Application 1445) proposed using the CPS, which scores both inflammatory cells and tumour cells which is different to the proposed use of PD-L1 testing in non-small cell lung cancer (NSCLC; tumour proportion score…
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Pdl1 testing cps score