Phosphodiesterase 5 inhibitors list
[DOCX File]Question 1:
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PDE5 inhibitors. The recommended starting doses for the following CYP3A4 substrates are as follows: Sildenafil 25 mg. Tadalafil 2.5 mg. Vardenafil 2.5 mg. BCRP, breast cancer resistance protein; CYP, cytochrome P450; CVC, cenicriviroc; PDE5, phosphodiesterase type 5
[DOCX File]GCS 16
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Goals of therapy include improving symptoms and quality of life, delaying disease progression, and prolonging survival. PAH-specific pharmacological therapies aimed at the underlying disease include prostacyclin analogs, endothelin receptor antagonists (ERAs), and phosphodiesterase inhibitors (PDE-5 inhibitors).
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Phosphodiesterase type 5 inhibitors. Sildenafil and tadalafil are phosphodiesterase type 5 (PDE5) inhibitors. A PDE-5 inhibitor works by opening the blood vessels in the lungs to allow blood to flow through more easily. The advent of PDE5 inhibitors for PAH treatment introduced a second class of oral agents in addition to ERAs,
[DOC File]UKMi Q&A xx - SPS
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: Headache, flushing, dyspepsia, nasal congestion, visual color changes, back, lower limb pain for all phosphodiesterase-5 inhibitors (PDE5); CI: None of these agents should be used in patients taking nitrates or alpha blockers.
[DOC File]National PBM Monograph Template Rev20091005
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Combination therapy with endothelin receptor antagonists, phosphodiesterase type-5 inhibitors and prostacyclin analogues did not affect survival but improved multiple outcome measures such as 6MWD, functional class and quality of life.(16) In conclusion, PH treatment remains mainly supportive in ILDs with the exception of systemic sclerosis ...
[DOCX File]List of Tables
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Phosphodiesterase type 5 (PDE-5) inhibitors and soluble guanylate cyclase (sGC) stimulators interfere with the nitric oxide pathway and help to relax the pulmonary arteries and lower the pressure within the arteries. PDE-5 inhibitors also inhibit the growth of smooth muscle lining blood vessel walls, a contributing factor in the development of PAH.
[DOC File]International Journal of Medical Sciences
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Risk of prolonged and/or enhanced effects. Glyceryl trinitrate and other nitrates. Unknown Hypotension Icariin component is a phosphodiesterase -5 inhibitor. Nitric Oxide donor and a phosphodiesterase -5 inhibitor considered contraindicated. Drugs causing hypotension Unknown …
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63.Gacci, M, Corona, G, Salvi, M et al: A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with alpha-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol 2012, 61: 994. 64.Ficarra, V, Novara, G, Rosen, RC et al: Systematic review and meta-analysis of studies
Erectile Dysfunction Causes, Treatment, Drugs & Side Effects
vitreous haemorrhage, ischaemic optic neuropathy, Giant Cell/temporal arteritis, Drugs (phosphodiesterase-5 inhibitors such as Viagra), migraine . Marking (a) : 10% each up to 50%. 9b.Clinical features: Rare under 50yo, peaks in 8th decade, median age of onset 75. 3.7 female: 1male.
[DOCX File]List of Tables
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List the 5 most relevant topical medications used in primary open angle glaucoma and explain why they are used: (5 marks) Prostaglandin analogues (e.g. ... HSV), Retinal detachment, vitreous haemorrhage, ischaemic optic neuropathy, Giant Cell/temporal arteritis, Drugs (phosphodiesterase-5 inhibitors such as Viagra), migraine .
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