Phosphodiesterase inhibitor medications
[DOC File]Pharmacy Benefits Management Services Home
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It is a phosphodiesterase inhibitor causing bronchodilation and some anti-inflammatory effects. Produces high amounts of CNS stimulation and diuresis. It is metabolized by CYP1A2 and has many DDI. Narrow TI, so you must monitor levels. ADRs include N, V, epigastric pain, tachycardia, and seizures. Caffeine is the main chemical in xanthine ...
[DOC File]Asthma Medications - Josh Corwin
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Phosphodiesterase 4D (PDE4D) ... Genetic variation in 2c19 allows for the identification of poor metabolizers of medications that are metabolized through the 2c19 pathway, including anti-epileptics, anti-convulsants, and psychotherapeutic drugs. ... increases circulating levels of plasminogen activator inhibitor (PAI), thus lowering levels of ...
[DOC File]National PBM Monograph Template Rev20091005
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Crisaborole topical ointment, 2%: Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in …
[DOC File]Trade
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Misc Medications: (Phosphodiesterase Inhibitors) 14. HEART AND BLOOD PRESSURE MEDICATIONS 14 Angiotensin Converting Enzyme Inhibitors 14 Angiotensin II Receptor Blockers 14 Angiotensin Converting Enzyme Inhibitor/Diuretic Combinations 14 Antiarrhythmics 14 Beta Blockers 15 Calcium Channel Blockers 15
[DOCX File]NINDS Stroke CDE Project Biospecimens and Biomarkers ...
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Goals of therapy include improving symptoms and quality of life, delaying disease progression, and prolonging survival. PAH-specific pharmacological therapies aimed at the underlying disease include prostacyclin analogs, endothelin receptor antagonists (ERAs), and phosphodiesterase inhibitors (PDE-5 …
[DOCX File]PatientPop
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Platelet aggregation inhibitor ... Clopidogrel does not inhibit phosphodiesterase activity. Clopidogrel acts by irreversibly modifying the platelet ADP receptor. Consequently, platelets exposed to clopidogrel are affected for the remainder of their lifespan. ... Oral medications that are dependent on gastric emptying for bioavailability should ...
Daliresp or Roflumilast for COPD
Phosphodiesterase Inhibitors. Nitric oxide (NO), produced in endothelial cells, causes vasodilation through the production of cyclic guanosine 3’-5’ monophosphate (cGMP) in the vascular smooth muscle.37 Overexpressed in the lungs of patients with PAH, phosphodiesterase type-5 (PDE5) is responsible for the breakdown of cGMP.
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