Prolonged benzodiazepine withdrawal syndrome
Who is at risk of withdrawal adverse reactions after benzodiazepine discontinuation?
Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages (i.e., higher and/or more frequent doses), those who have had longer durations of use (see WARNINGS: Dependence and Withdrawal Reactions).
Can benzodiazepines cause seizures?
Abrupt discontinuation or rapid dosage reduction of benzodiazepines or administration of flumazenil, a benzodiazepine antagonist, may precipitate acute withdrawal reactions, including seizures, which can be life-threatening.
Are benzodiazepines a concomitant drug?
Concomitant use of benzodiazepines, including Valium, and opioids may result in profound sedation, respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate.
Can benzodiazepines cause a coma?
Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required.
[PDF File]The benzodiazepine withdrawal syndrome
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Physiological dependence on benzodiazepines is accompanied by a withdrawal syndrome which is typically characterized by sleep disturbance, irritability, increased tension and anxiety, panic attacks, hand tremor, sweating, difficulty in concentration, dry wretching and nausea, some weight loss, palpitations, headache, muscular pain and stiffness ...
Complicated Withdrawal Phenomena During Benzodiazepine ...
long-term benzodiazepine use is proposed to be related to downregulation. and allosteric decoupling of the γ-aminobutyric acid/benzodiazepine receptor. complex. This case series describes 2 patients with prolonged (>2 weeks) recurrent complications during attempted tapering of benzodiazepine doses.
[PDF File]Benzodiazepine Withdrawal Syndrome (BZWS) An Evidence I would ...
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Benzodiazepine Withdrawal Syndrome (BZWS) An Evidence-based Summary for Professionals Diagnosing BZD or Z-drug Dependence and Withdrawal Patient has history of BZD or Z-drug use Higher dose and/or longer use increase risk > 4 weeks use typical Intermittent use, or 2-4 weeks use (lower probability)
[PDF File]Benzodiazepine Dependence And Withdrawal: Identification And ...
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distinct withdrawal syndromes. High-dose benzodiazepine use between 1 and 6 months can produce an acute sedative-hypnotic withdrawal syndrome. In contrast, low-dose therapeutic range benzodiazepine use longer than 6 months can produce a prolonged, subacute low-dose benzodiazepine withdrawal syndrome. Daily,
[PDF File]diazepam TABLETS R WARNING: RISKS FROM CONCOMITANT USE WITH ...
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Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer...
Enduring neurological sequelae of benzodiazepine use: an ...
Symptoms of nervousness/anxiety/fear, sleep disturbances, low energy, and difficulty focusing/distractedness were experienced by the majority of respondents (⩾85%) and, along with memory loss, were the symptoms of longest duration.
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