Propofol side effects in elderly

    • [PDF File]The propofol-sparing effect of intravenous lidocaine in elderly ...

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      with propofol in colonoscopy was statistically safe to the patients with higher satisfaction feedback. However, the increased sensitivity to propofol in some individuals, espe-cially in elderly patients could lead to the development of profound hypotension and prolonged apnea when propo-fol is used as a sedative during colonoscopy.

    • Conscious sedation with propofol in elderly patients: a prospective ...

      Propofol, an ultrashort acting anaesthetic agent, is being increasingly used in the field of gastrointestinal endoscopy.13–15 With its fast onset of action of 30–60 s, a distribution half-life of 2–4 min, and its rapid recovery time, propofol avoids some of the concerns cited.16 Even if the effects may be delayed in elderly patients due to a

    • Effects of propofol, dexmedetomidine, and midazolam on postoperative ...

      especially in elderly patients.[14,15] Propofol is a GABAer-gic agent. It has been shown that in elderly patients undergoing hip fracture repair under spinal anesthesia with propofol sedation, the prevalence of delirium can be decreased by 50% with light sedationcompared withdeep sedation.[15] Dexmedetomidine is an alpha-2 adrenore-

    • PROPOFOL USE DURING GASTROINTESTINAL ENDOSCOPY - ASGE

      propofol alone did not provide adequate analgesia.17 A double-blinded study randomized 57 patients to one of three groups: diazepam/meperidine, midazolam/fen-tanyl, or propofol/fentanyl. There were no significant differences in sedation,analgesia,recovery rate or inci-dence of side-effects.18 Another randomized controlled

    • [PDF File]Application effects of remimazolam and propofol on elderly patients ...

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      remimazolam and propofol to maintain anesthesia of 60 elderly patients undergoing elective hip replacement, and compares the dierences in circulatory indicators, stress indicators, anesthetic eects and perioperative pain degree of the two so as to provide more reference for choosing a safe and eective anesthesia regimen for elderly patients

    • [PDF File]DIPRIVAN (propofol) injectable emulsion, USP - Food and Drug Administration

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      sedative/anesthetic effects by the positive modulation of the inhibitory function of the neurotransmitter GABA through the ligand-gated GABA A receptors. Pharmacodynamics . Pharmacodynamic properties of propofol are dependent upon the therapeutic blood propofol concentrations. Steady-state propofol blood concentrations are generally proportional to

    • [PDF File]Propofol Package Insert - Dr. Reddy's Laboratories

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      Undesirable side effects, such as cardiorespiratory depression, are likely to occur at higher blood concentrations which result from bolus dosing or rapid increases in infusion rates. An adequate interval (3 minutes to 5 minutes) must be allowed between dose adjustments in order to assess clinical effects.

    • Recovery times and side effects after propofol infusion and after ...

      after propofol and possible delayed recovery after midazolam.’ l.I2 The haeinodynamic and respiratory changes were accept- able in our patients, although care must be taken in the elderly and high risk patients. Side effects were rare, apart from shivering, which was commoner after propofol and always ceased when the infusion was stopped.

    • The effects of remifentanil-propofol combined with dexmedetomidine on ...

      under sedation for colonoscopy [6]. Propofol-remifentanil allows earlier cognitive recovery than propofol-dexmedetomidine [7]. These results showed that propofol-remifentanil may be a good choice of anesthesia in elderly surgical patients. However, both propofol and remifentanil have a rapid onset, short duration, and rapid recovery, which leads to

    • Safety and efficacy of etomidate and propofol anesthesia in elderly ...

      patients. However, due to side effects, including myoclonus and post‑operative nausea and vomiting (PONV), etomidate is rarely used in patients undergoing gastroscopy. The aim of the present prospective study is to determine the safety, efficacy, cost effectiveness, side effect profile and recovery time of a combination of propofol and etomidate,

    • Sensitivity to propofol in the elderly - Association of Anaesthetists

      Side effects were more marked with the rapid injection and doses in excess of 1.75 mglkg causedsignificant hypotension and apnoea in the elderly. These studies reveal marked sensitivity to propofol in the elderly with respect to both induction dose and acute toxicity. Key words Anaesthetics, intravenous; propofol.

    • [PDF File]DIPRIVAN (Propofol) INJECTABLE EMULSION, USP - Food and Drug Administration

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      9 Pharmacodynamic properties of propofol are dependent upon the therapeutic blood propofol 10 concentrations. Steady-state propofol blood concentrations are generally proportional to 11 infusion rates. Undesirable side effects, such as cardiorespiratory depression, are likely to

    • [PDF File]Effects of Ketamine-Propofol Mixture on Intraocular Pressure and ...

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      amine, in subanesthetic doses, provides haemodynamic stability in elderly patients (5-7). Side effects, such as hypertension and increased IOP, restrict its use as a single drug (8). The effects of ketamine and propofol on haemodynamic and respiratory systems are complementary to each other, and their

    • [PDF File]The effects of remifentanil-propofol combined with dexmedetomidine on ...

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      with fewer postoperative side effects and reduced analgesic requirements. The objective was to determine whether ... Propofol, Cognitive dysfunction, Elderly Introduction Postoperative cognitive dysfunction (POCD) is a com-mon postoperative complication that adversely affects the patients’ social independence, quality of life, and mortality ...

    • [PDF File]Hemodynamic Stability during Induction of Anesthesia in Elderly ...

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      instability caused by propofol induction. Current study evaluates hemodynamic effects of ketamine and propofol in comparison to etomidate and propofol during anesthesia induction. Methods: Sixty-two patients over 50 years old undergoing elective surgeries were randomly assigned to ketamine + propofol (ketofol) (n=30) and etomidate + propofol

    • [PDF File]DIPRIVAN - propofol injection, emulsion Fresenius Kabi USA, LLC

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      mg/mL of propofol suitable for intravenous administration. Propofol is chemically described as 2,6-diisopropylphenol. The structural formula is: Propofol is slightly soluble in water and, thus, is formulated in a white, oil-in-water emulsion. The pKa is 11. The octanol/water partition coeff icient for propofol is 6761:1 at a pH of 6 to 8.5.

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