Regulation of acetyl coa carboxylase
[PDF File]Regulation of acetyl-CoA carboxylase - CyberLeninka
https://info.5y1.org/regulation-of-acetyl-coa-carboxylase_1_592ae3.html
Insulin, calcium and the control of mammalian metabolism 223 Regulation of acetyl-CoA carboxylase R.W. Brownsey1, A.N. Boone, J.E. Elliott, J.E. Kulpa and W.M. Lee Department of Biochemistry and Molecular Biology and The Diabetes Research Group of the Life Sciences Institute, The University of British Columbia,
How Does Polymerization Regulate Human Acetyl-CoA Carboxylase 1?
How Does Polymerization Regulate Human Acetyl-CoA Carboxylase 1? Jia Wei and Liang Tong* Department of Biological Sciences, Columbia University, New York, New York 10027, United States A cetyl-CoA carboxylases (ACCs) are biotin-dependent enzymes that catalyze the carboxylation of acetyl-CoA to generate malonyl-CoA, which is used as a two-carbon ...
Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl ...
which together pinpoint plastidic acetyl-CoA carboxylase (ACCase) as the enzymatic target of feedback inhibition. To identify the sig-nal responsible for feedback, a variety of Tween esters were tested for their effects on the rate of fatty acid synthesis. Maximum in-hibition was achieved upon feeding oleic acid (18:1) Tween esters
The subcellular localization of acetyl-CoA carboxylase 2
fatty acids (1–3), malonyl-CoA has been implicated in the regulation of the carnitine palmitoyl-CoA shuttle system that is involved in the mitochondrial b-oxidation of long-chain fatty acids. In animals, two isoforms of the carboxylase have been identified, ACC1 (Mr 5 265,000) and ACC2 (Mr 5 280,000) (4, 5).
[PDF File]Regulation of acetyl-CoA carboxylase - ResearchGate
https://info.5y1.org/regulation-of-acetyl-coa-carboxylase_1_efcd55.html
Regulation of acetyl-CoA carboxylase R.W. Brownsey1, A.N. Boone, J.E. Elliott, J.E. Kulpa and W.M. Lee Department of Biochemistry and Molecular Biology and The Diabetes Research Group of the Life ...
Regulation of Acetyl-CoA Carboxylase: Properties of CoA ... - JSTOR
The specific activity of acetyl-CoA carboxylase in such prep-arations was between 70 and 90 milliunits/mg of protein in the presence of 10 mM citrate. Assay of Acetyl-CoA Carboxylase. Acetyl-CoA carboxylase activity was measured as described (16). One unit of activity is defined as 1 timol of malonyl-CoA formed per minute at 370C.
Regulation of the Activity of Acetyl Coenzyme A Carboxylase by ...
Pahnitoyl-CoA (100 PM), in the presence of albumin (24 mg per ml), inhibited the incorporation of [14C]citrate into fatty acids in a cytosol fraction of chick liver and inhibited the activity of acetyl-CoA carboxylase purified from chick liver. Under similar incubation conditions, pahnitoyl-CoA
Acute Hormonal Control of Acetyl-CoA Carboxylase
nephrine, and the like) on acetyl-CoA carboxylase have yielded confusing and contradicting results. Although insulin is known to stimulate fatty acid synthesis while glucagon antagonizes its effects, both hormones have been reported to induce phosphorylation of acetyl-CoA carboxylase in dis- rupted tissues or cells (32-37). While there is a ...
Plant Acetyl-CoA Carboxylase: Structure, Biosynthesis, Regulation, and ...
Plant Acetyl-CoA Carboxylase: Structure, Biosynthesis, Regulation, and Gene Manipulation for Plant Breeding Yukiko SASAKI1;y and Yukio NAGANO2 1Genesis Research Institute, Inc., 4-1-35 Noritake-shinmachi, Nishi-ku, Nagoya 451-0051, Japan 2Analytical Research Center for Experimental Sciences, Saga University, Saga 840-8502, Japan Acetyl-CoA carboxylase (ACCase) catalyzes the first
Regulation of acetyl-CoA carboxylase by guanine nucleotides.
Acetyl-coA carboxylase was assayed by a previously published technique (16) with slight modification. In the routine assay for enzyme activators, activator fractions were added to tubes containing assay buffer, Mg" (5 m~), and citrate (0.2 I") at 4 "C. Acetyl-coA, ATP, and NaHI4CO3 were added just prior to assay. The tube was
Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 ...
The malonyl-CoA produced by ACC can be used by FA synthase (FAS) for the sequential 2-carbon elongation reactions that generate palmitic acid (C16:0) in the cytosol. While both ACC1 and ACC2 produce malonyl-CoA, ACC1 is predominantly cytosolic and generates malonyl-CoA that is used by FAS to synthesize palmitic acid. ACC2 is associated with the ...
Hormonal Regulation of Acetyl-CoA Carboxylase Isoenzyme Gene Transcription
Acetyl-CoA, an intermediate product of glycolysis, is supplied for fatty acid synthesis when carbohydrate intake is sufficient. Acetyl-CoA carboxylase (ACC), consisting of two isoenzymes ACC1 and ACC2, mediates the conversion from acetyl-CoA to malonyl-CoA, and thus plays a key role for the regulation of lipogenesis.
Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart.
THE JOURNAL OF BIOLOGICAL CHEMISTRY 0 1993 by The American Society for Biochemistry and Molecular Biology, Inc VOl. ,268. No. 34. Issue of December 5, pp. 2583625845.1993 Printed in U. S.A. Acetyl-coA Carboxylase Regulation of Fatty Acid Oxidation in the Heart* (Received for publication, April 8, 1993, and in revised form, August 2, 1993) Maruf SaddikSj, James GambleSll, Lee A. Wittersll, and ...
[PDF File]A unified molecular mechanism for the regulation of acetyl-CoA ...
https://info.5y1.org/regulation-of-acetyl-coa-carboxylase_1_aecada.html
A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation JiaWei 1 ,YixiaoZhang 2 ,Tai-YuanYu 3 ,KianoushSadre-Bazzaz 1 ,MichaelJRudolph 1 ,GabrieleAAmodeo ,
Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate regulated ...
biotin carboxyl carrier protein subunits of the plastidial acetyl-CoA carboxylase (ACCase) and three other proteins containing a similar biotin/lipoyl-binding motif as putative PII targets. ACCase is a key enzyme initiating the synthesis of fatty acids in plastids. In in vitro reconstituted assays supplemented with exogenous ATP, recombi-
[PDF File]Regulation of mammalian acetyl-CoA carboxylase - ResearchGate
https://info.5y1.org/regulation-of-acetyl-coa-carboxylase_1_d4e37e.html
It is clear that down-regulation of a specific ... Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCa and ACCB, appear to have ...
Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic ...
also reports that malonyl-CoA regulates orexigenic responses in hypothalamus (8) and insulin secretion by pancreatic -islets (9, 10). Malonyl-CoA is generated by two isoforms of acetyl-CoA carboxylases, ACC1 and ACC2 of molecular mass 265 kDa and 280 kDa, respectively (11–16). ACC1 is a cytosolic enzyme, and ACC2 is associated with ...
Regulation of Acetyl CoA Carboxylase and Carnitine Palmitoyl ...
BARBARA E. CORKEY, AND WEN GUO. Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes. Obes Res. 2005;13:1530–1539. Objective: Acetyl CoA carboxylase (ACC) is a key enzyme in energy balance. It controls the synthesis of malonyl-CoA, an allosteric inhibitor of carnitine palmitoyltransferase-1 (CPT-I).
[PDF File]Short- and long-term nutritional modulation of acetyl-CoA carboxylase ...
https://info.5y1.org/regulation-of-acetyl-coa-carboxylase_1_ff2924.html
Acetyl-CoA carboxylase (ACoAC) catalyses the carboxylation of acetyl-CoA into malonyl-CoA. This product plays a pivotal role in the regulation of energy metabolism since it is both a substrate for fatty acid synthesis and an inhibitor of the oxidative pathway. The present
Louisiana State University LSU Digital Commons
The results indicated the two active sites of acetyl-CoA carboxylase interact. Both . in vitro. and . in vivo. pull-down assays demonstrated that the three components of . E. coli. acetyl-CoA carboxylase form a multimeric complex and that complex formation is unaffected by acetyl-CoA, AMPPNP, and mRNA coding for carboxyltransferase.
Nearby & related entries:
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.