Rhabdomyolysis vs myositis
[DOCX File]Title: Statin Induced Autoimmune Myopathy
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Inclusion body myositis: unlike polymyositis, this presents with insidious onset of . asymmetric (vs symmetric), ... If biopsied, lesions are PAS-positive, congo red negative (vs apple green in amyloid), with amorphous or fibrillar appearance on EM. Treatment is that of the underlying disorder. Amyloidosis: ... rhabdomyolysis), and serotonin
[DOCX File]MRCP Notes Compilation - Nigel Fong - Notes Site - Home
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Myositis occurred in 0.4% (12/3075) of patients who received Tecentriq monotherapy. The median time to onset was 5.4 months (range: 0.7 to 11.0 months). The median duration was 3.5 months (range 0.1 to 22.6+ months, + denotes a censored value). Myositis led to discontinuation of Tecentriq in 1 …
Category: Acute Exacerbations of Anemia
Rhabdomyolysis and myoglobinuria were rarely noted (1/10 patients in one study, 4/19 in another).e121,e131 Most patients, even when asymptomatic, exhibited calf hypertrophy.e120,e121 Six of 7 in one family had pes cavus.e122 Scapular winging, facial weakness, and rigid spine were not seen.
Myositis: Symptoms and Causes
In a letter to the editor, pharmacists working with the FDA collected all cases of statin-associated fatal rhabdomyolysis that had been reported to the FDA before June 26, 2001.77 Cases were included if there was a clinical diagnosis of rhabdomyolysis, a temporal association between rhabdomyolysis and the use of a statin, and death was either ...
[DOC File]STATIN-FIBRATE REPORT: Focus on Safety
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Rhabdomyolysis may occur in severe cases. In addition to vaso-occlusion, other causes include drugs, injury, exercise, infection, autoimmune conditions, or a paraneoplastic process. Diagnostic Criteria: Myositis, fasciitis, and myonecrosis are difficult to distinguish clinically.
[DOCX File]1. Respiratory Medicine - Nigel Fong
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: Autoimmune myositis is rare, with an estimated prevalence of 22 in 100,000 (20) and statin-induced autoimmune myositis is rarer still, with a prevalence of 1 in 100,000 (21). There is less of a female preponderance in statin-induced autoimmune myositis (20), …
[DOC File]Evidence-based Guideline: Diagnosis and Treatment of Limb ...
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4.1% withdrew due to AEs but none were serious. The incidence of: ↑CPK (5.8%), nasopharyngitis (5.4%) and myalgia (4.1%) were most common with no reports of myopathy/myositis/rhabdo or ↑ LFTs. Sansanayudh (2010) R, OL, AC N = 98 Pitava 1 vs. Atorva 10 8 Primary Endpoint: % Δ in LDL, TC, proportion of pts. reaching LDL goal
[DOCX File]Attachment: Product Information Atezolizumab
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prevalence (decreasing in USA) ≈ 25% (28% men and 24% women; vs. in 1965 - 52% and 34%). highest in blacks, blue-collar workers, less-educated persons, persons in lower socioeconomic strata. other risk factors: smoking parents / peers, schizophrenia, major depression.
[DOC File]Pharmacy Benefits Management Services Home
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Rhabdomyolysis has also been reported rarely. Patients receiving fenofibrate and complaining of muscle pain, tenderness or weakness should have prompt medical evaluation for myositis, including serum creatinine level determination. If myositis is suspected or if CPK rises to 5 times the upper limit of normal, fenofibrate therapy should be ...
[DOCX File]AusPAR Attachment 1. Product Information for fenofibrate
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Inclusion body myositis: unlike polymyositis, this presents with insidious onset of asymmetric (vs symmetric), proximal and distal (vs proximal) muscle weakness especially affecting finger flexors and quadriceps. Dysphagia may develop but myalgia is minimal. On examination there is atrophy and hyporereflexia. CK is
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