Role of dopamine in adhd
ADHD Causes & Risk Factors: Genetics, Biology, and More
ADHD is thought to involve the dopaminergic system, specifically the dopamine transporter gene (DAT1), the genes expressing D4, D3, and D2 dopamine receptors, and dopamine-beta-hydroxylase (Simpson & Perry, 2003; Markowitz et al., 2003).
[DOC File]Etiological Factors in ADHD
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Another gene related to dopamine, the D4RD (repeater gene) has more recently been found to be overrepresented in children with ADHD. While in its early stages in investigations of ADHD, such molecular genetic research holds promise for the development of genetic tests for ADHD and perhaps for identifying subtypes of this disorder.
[DOC File]Attention-Deficit Hyperactivity Disorder
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But the new findings zero in on dopamine's role in the condition. The first study focuses on the genetics of ADHD -- specifically, on a particular variation of the DRD4 gene, which makes a dopamine receptor in the brain. Dopamine is an important chemical messenger used between nerve cells in the brain.
[DOC File]New Clues on Causes of ADHD
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More recently have been the isolation of a "dopamine transporter gene" and a “dopamine repeater gene”, both of which are related to a neurotransmitter that has been heavily implicated in ADHD. The "dopamine repeater gene (which is characterized by multiple copies) is especially of interest in that it has previously also been associated with the personality trait of novelty …
[DOC File]ADHD
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Rodent Models of Hyperactivity and Hyperreactivity: Role of Dopamine (DA) A number of rodent models – we would list 30 - have been proposed to investigate the putative neural substrates of impulsiveness, and the varied manifestations of hyperactivity in ADHD. ... Attention deficit/hyperactivity disorder--from brain dysfunctions to behaviour ...
[DOC File]ADHD: A HISTORICAL OVERVIEW
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Genetic – very high identical twin concordance 0.6-0.8, 1st degree relative risk of 20-25%. Possible role of dopamine related genes. Medical risks – in utero exposure to tobacco and alcohol, low birth weight, prematurity. Lead, carbon monoxide, heavy metals implicated in …
[DOC File]The control of responsiveness in ADHD by catecholamines:
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et al (2000) Adult attention deficit hyperactive disorder and the dopamine D4 receptor gene: Am. J. Med. Gene 96: 273-277. Munden, A.; Arcelus, J. (1999) The ADHD Handbook: Jessica Kingsley Publishers
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