Science translational medicine review process

    • The Fundamental Characteristics of a Translational Scientist

      KEYWORDS: translation, translational science, Translation Together, innovation T ranslational science for benefiting human health requires the convergence of a diverse array of disciplines, including biology, chemistry, informatics, computer science, engineering, medicine and public health, into a united effort to

    • REGENERATIVE MEDICINE Copyright © 2020 A blueprint for translational ...

      SCIENCE TRANSLATIONAL MEDICINE| REVIEW 2 of 10 that cells can readily adopt different phenotypic identities. This viewpoint has sparked intensive research into reprogramming strate-gies that seek to convert one somatic cell into another, without needing to form iPSCs. One method appeared to show that a brief

    • Emerging therapies for inherited retinal degeneration - Science

      SCIENCE TRANSLATIONAL MEDICINE| REVIEW Scholl et al., Sci. Transl. Med. 8, 368rv6 (2016) 7 December 2016 1of10. by causative mutations and secondary effects such as oxidative stress ... pletely arrest the degenerative process, despite the visual improvement observed in trials for RPE65-related retinal diseases (19). Neuroprotective

    • [PDF File]Translational Medicine In Geriatrics: A Systematic Review - ResearchGate

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      of the importance of translational science and medicine in improving patient health. ... To systematize the information regarding the systematic review process, the START® software (START®, v2 ...

    • [PDF File]Principles of Translational Science in Medicine From Bench to Bedside

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      1.1.2. The Scope of Translational Medicine, Its Remits, and Why We Need It 4 1.1.3. What Translational Medicine Can and Cannot Do 8 1.1.4. The Present Status of Translational Medicine (Initiatives and Deficiencies) 11 1.1.5. Translational Science in Medicine: The Current Challenge 15 1.2. References 17 2. TARGET IDENTIFICATION AND VALIDATION 18 ...

    • CARTILAGE Copyright © 2022 Navigating regulatory pathways for ...

      SCIENCE TRANSLATIONAL MEDICINE| REVIEW 2 of 20 a product classified as a biologic will be regulated by CBER and will require an Investigational New Drug (IND) appli-cation before clinical studies and a Bio-logics License Application (BLA) before market approval. Meetings with the FDA are held at specific times along the regulatory path-way.

    • WOUND HEALING Wound repair and regeneration: Mechanisms ... - Science

      healing process in ways that are currently poorly understood (Fig. 1). ... Molecular Medicine Cologne, University of Cologne, Cologne 50931, ... SCIENCE TRANSLATIONAL MEDICINE STATE OF THE ART REVIEW www.ScienceTranslationalMedicine.org 3 December 2014 Vol 6 Issue 265 265sr6 3.

    • PAIN Copyright © 2021 Brain circuits for pain and its treatment

      Mercer Lindsay et al., ci. ransl. ed. 13, eab7360 (2021) 10 November 2021 SCIENCE TRANSLATIONAL MEDICINE| REVIEW 1 of 21 PAIN Brain circuits for pain and its treatment Nicole Mercer Lindsay 1,2, Chong Chen1, Gadi Gilam3, Sean Mackey3*, Grégory Scherrer1,4* Pain is a multidimensional experience with sensory-discriminative, affective-motivational, and cognitive-evaluative

    • [PDF File]Overcoming Challenges in Translational Research - Sanguine

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      The NCATS defines translational science as "the field of investigation focused on understanding the scientific and operational principles underlying each step of the translational process." The proposed translational spectrum includes five stages of research ... A recently published review defined precision medicine as "the right medicine ...

    • Designing Regenerative Biomaterial Therapies for the Clinic - Science

      ferent parts of the world, but this review will be focused on the U.S. FDA, given that the United States accounts for 81% of research and ... CREDIT: Y. HAMMOND/ follows either PMA or the 510(k) process. SCIENCE TRANSLATIONAL MEDICINE STATE OF THE ART REVIEW www.ScienceTranslationalMedicine.org 14 November 2012 Vol 4 Issue 160 160sr4 2.

    • [PDF File]Transforming Translational Science

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      what is common across diseases and the translational process. Translation. is the process of turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and the public — from diagnostics and therapeutics to medical procedures and behavioral changes. Translational science

    • [PDF File]Journal of Clinical and Translational Science

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      in translational science in academic health centers. Through our efforts, we were able to improve timeliness, transparency, and efficiency of the review process. Received 1 March 2018; Revised 19 March 2018; Accepted 5 May 2018; First published online 4 October 2018 Key words: Lean 6 sigma, pilot awards, surveys, process mapping, research

    • NEURODEGENERATIVE DISEASE Copyright © 2019 Mouse models of ...

      models may therefore be an essential step in the translational process. MICE AND HUMANS ARE DIFFERENT Despite the remarkable similarities between us, mice are not mini ... SCIENCE TRANSLATIONAL MEDICINE| REVIEW 2 of 15 At the genome level, ~90% of mouse and human DNA falls into regions of conserved synteny, distributed between the 46 human ...

    • [PDF File]Journal of Clinical and Translational Science

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      Mapping the evolving definitions of translational research Daniel G. Fort1*, Timothy M. Herr1, Pamela L. Shaw 2, Karen E. Gutzman and Justin B. Starren1 1 Department of Preventive Medicine, Feinberg School of Medicine, Division of Health and Biomedical Informatics, Northwestern University, Chicago, IL, USA 2 Galter Health Sciences Library, Feinberg School of Medicine, Northwestern University ...

    • BIOENGINEERING Copyright © 2022 Translating musculoskeletal ...

      SCIENCE TRANSLATIONAL MEDICINE| REIE 2 of 17 resident stem cell proliferation for subsequent tissue repair (12). Specifically, this stage of regenerative response is associated with proinflammatory transition of macrophages from an M0 to M1 phenotype and accumulation of CD8+ and CD4+ T helper 1 (T H1) and T H17 cells (11). The final stage of ...

    • [PDF File]GUIDE TO AUTHORS - American Society for Clinical Pharmacology and ...

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      SCOPE Web of Science (Thomson Reuters). Clinical and Translational Science (CTS), an official journal of the American Society for Clinical Pharmacology and Therapeutics, highlights original translational medicine research that helps bridge laboratory discoveries with the diagnosis and treatment of human disease. Translational medicine is a multi-

    • [PDF File]Translational precision medicine: an industry perspective

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      term Translational Precision Medicine to refer to this emerging discipline. e Translational Precision Medicine- concept inte grates core components from both translational medi-cine (mechanism-based early drug development) and precision medicine (patient-centric late drug devel-opment) into an end-to-end biomarker-guided drug development cycle.

    • [PDF File]SCIENCE TRANSLATIONAL MEDICINE - Massachusetts Institute of Technology

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      SCIENCE TRANSLATIONAL MEDICINE| RESEARCH ARTICLE 3 of 13 (more than five times of the original length; fig. S5A), and robust (fracture toughness of 758 J m−2; fig. S6) hydrogel. The swelling- driven lateral dimensional changes (i.e., increase in length and width) of the GI patch have been eliminated (fig. S3) by introducing a pre-

    • [PDF File]The Science Manuscript handling at Science Signaling - q-bio

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      Access to Science, Science Signaling, and Science Translational Medicine ! Immediate access: Research authors receive a link to their article immediately after publication that can be put on a web page to allow free access to the article. ! 6 months after publication: Accepted version of peer-reviewed content can

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