Scleroderma and polymyositis
The Polymyositis-Scleroderma Autoantigen Interacts …
The Polymyositis-Scleroderma Autoantigen Interacts with the Helix-Loop-Helix Proteins E12 and E47* (Received for publication, January 27, 1997) Choon-Joo Kho‡, Gordon S. Huggins‡§¶, Wilson O. Endege, Cam Patterson, Mukesh K. Jain, Mu-En Lee§i**, and Edgar Haber§¶i‡‡ From the Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts …
[PDF File]Scleroderma and Myositis
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20% of limited scleroderma patients have anti-Scl-70. Anti-centromere antibody occurs in 80% to 90% of patients with limited scleroderma. 10% to 15% of patients with diffuse PSS have anti-centromere. The presence of anti-Scl-70 predicts a worse prognosis. Serology
[PDF File]Bilateral coxitis in scleroderma-polymyositis overlap syndrome
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Bilateral coxitis in scleroderma-polymyositis overlap syndrome Abstract Joint manifestations in scleroderma (Scl) and polymyositis (PM) are dominated by inflammatory arthralgia. Arthritis is less common and preferentially affects the hands, wrists, knees, and ankles. Involvement of the hip has been rarely reported in the literature. We report a ...
[PDF File]Scleroderma Systemic Lupus Erythematosus …
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Systemic Lupus Erythematosis Incidence –20-150/100,000 –150-410 in women Peak age 17-40 Female:Male –5:1 in peak ages –2:1 for all age
[PDF File]RESEARCH ARTICLE Open Access Scleroderma …
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scleroderma-polymyositis (SSc-PM) overlap compared with a population of patients with systemic sclerosis (SSc) and polymyositis (PM). Methods: A three-way comparison of patients with SSc-PM overlap (n=25) with patients with SSc (n=397) and PM (n=40) on clinical and myopathologic features and causes of death. One neuropathologist blinded for the
PM–Scl-75 Is the Main Autoantigen in Patients With the ...
Key points in Scleroderma • Complications of scleroderma are increasingly better managed • Recognize the presence of concomitant Raynauds and GERD as a possible clinical manifestation of underlying limited scleroderma and therefore the potential for longterm risk of pulmonary hypertension
SYSTEMIC SCLEROSIS: Diffuse and Limited - Scleroderma
is to determine whether homogeneous-defined SSc/polymyositis overlap (SSc-PM overlap) is associated with a worse survival rate compared with SSc without PM. Methods. Data from the Nijmegen Systemic Sclerosis cohort were used. Incidence rates were calcu-lated from the observed number of deaths and followup time. Survival analysis using Cox ...
[PDF File]Systemic Sclerosis-Polymyositis Overlap Syndrome ...
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with clinical symptoms of polymyositis (PM) or dermato-myositis (DM) and scleroderma (the so-called PM/ scleroderma overlap syndrome) that are capable of precipitating antigens from calf thymus extract were first described in 1977 (1). The antigen recognized by these autoantibodies was shown to be a nucleolar complex,
Scleroderma/Polymyositis Overlap Syndromes and Their ...
Systemic Sclerosis-Polymyositis Overlap Syndrome Associated with Autoimmune Hepatitis and Cerebral Vasculitis Cristina Pamfil 1 , Mihnea T. Zdrenghea 2 , Petru A. Mircea 3 , Roberta M. Manzat ...
Polymyositis: a cause of acute renal failure
of systemic scleroderma was generally absent, except for lung fibrosis found in five cases and functional pulmo- nary changes without evident fibrosis in two others.
Polymyositis - Better Health Channel
The term scleroderma literally means hard skin. But scleroderma (also known as systemic sclerosis, or SSc) is much more than a skin disorder. While nearly all persons with systemic sclerosis have issues with their skin, particularly excessive scarring, swollen, tight, or hard skin on their fingers, they also have organ system involvement.
[PDF File]Pulmonary involvement in polymyositis and dermatomyositis
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Polymyositis and dermatomyositis are rare diseases, affecting only 6–8 people out of 100,000. It mostly affects adults, although children can be affected by a type of dermatomyositis called juvenile dermatomyositis. At a glance Polymyositis and dermatomyositis Polymyositis and dermatomyositis are rare diseases, affecting only 6–8 people out
[PDF File]polymyositis-scleroderma overlap.
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Pulmonary involvement in polymyositis and dermatomyositis Pulmonary complications play an important role in causing morbidity and mortality in myositis, and interstitial lung disease (ILD) has been reported in up to 65% of myositis patients. Clinical symptoms including cough and dyspnoea are common, but they are not reliable for ILD detection.
[PDF File]Patients with Systemic Sclerosis/polymyositis Overlap Have ...
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with polymyositis met the definite category as defined by Medsger (21, 22). 54 patients with rheumatoid arthritis had definite or classical disease according to the American Rheumatism Association criteria (23). 26 patients with over-lap syndrome each fulfilled two or more ofthe above sets of criteria (3, SLE-scleroderma-polymyositis; 7, SLE ...
[PDF File]Polymyositis and dermatomyositis information booklet
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Polymyositis: a cause of acute renal failure A. J. P. Lewington 1 , R. D'Souza 1 , S. Carr 1 , K. O'Reilly 2 and G. L. Warwick 1 Departments of 'Nephrology an 2dHistopathology , Leicester General ...
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