Severe chronic microangiopathy of the white matter
Minocycline reduces intracerebral hemorrhage–induced white ...
tein kinase 1 (RIPK1) activation.7 Because of white matter's critical role in neurotransmission, WM injury may also lead to severe sen-sorimotor dysfunction, neurobehavioral impairment, and cognitive disorders.8,9 Therefore, protecting against WM injury after ICH is a pressing concern.
Cognitive Ability and Brain Structure in Type 1 Diabetes
Severe hypoglycemia did not influence cognitive ability or brain structure. Background diabetic retinopathy was associated with small focal white-matter hyperin-tensities in the basal ganglia (33.3 vs. 4.7%, after cor-rection for age, P 0.005) and significant cognitive disadvantage, affecting fluid intelligence (P 0.008,
[PDF File]Neuroimaging in Cerebral Small Vessel Disease
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of white matter lesions (WMLs) and brain atrophy can also be readily determined from CT brain scans - features which may predict subsequent cognitive impairment and dementia. There is a very good agreement between brain atrophy and presence of moderate-severe white matter lesions on CT and MRI measures19, 20.
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Background: Cerebral chronic white matter (WM) microangiopathy is common with ageing and vasculopathy. It is known to be better detected on magnetic resonance imaging (MRI) compared to computed tomography (CT). Objective: To determine the detectability of WM microangiopathy on CT compared to MRI; utilizing a subjective visual approach.
Chronic Kidney Disease Is Associated With White Matter ...
log-white matter hyperintensity volume ( 1.479; 95% CI, 1.067 to 2.050). Conclusions—The association between moderate–severe chronic kidney disease and white matter hyperintensity volume highlights the growing importance of kidney disease as a possible determinant of cerebrovascular disease and/or as a marker of microangiopathy.
[PDF File]Functional MR Imaging in Patients with Carotid RESEARCH ...
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and microangiopathy 15/F/74 Stroke 6 95 65 0.41 0.632 0.16 1.038 0.27 Acute deep white matter ischemic stroke 16/M/66 None N/A 80 0 0.02 1.085 0.31 1.107 .29 Chronic microangiopathy 17/M/67 Stroke 12 70 0 1.32 0.753 0.17 2.076 0.67 Acute deep white matter ischemic stroke 18/M/66 AF 7 95 0 0.06 1.141 0.27 1.079 0.21 Chronic microangiopathy
[PDF File]MRI brain white matter change: spectrum of change – how ...
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at the impact of age-related brain white matter changes on the transition to disability in the elderly and found that severe white matter changes predict rapid global functional decline at 3 years.8 The link between imaging appearances and function suggests that screening for risk factors of stroke and dementia may be useful in this patient group.9
[PDF File]Neurological and ocular manifestations of chronic cerebral ...
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cerebral microangiopathy resulting in hypoperfusion and dysfunction of various brain regions. Subcortical and periventricular white matter are most affected due to the most unfavorable blood supply conditions [5, 7]. Although cognitive impairment is a major clinical manifestation of CCI, with the severity of impairment
[PDF File]Open Access Review Update on cerebral small vessel disease ...
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2) cm diameter in the white matter, basal ganglia, pons or brainstem, and is consistent with a lacunar clinical syndrome.7 It is commonly attributed to an abnormality in a single small deep perforating (or lenticulostriate) artery. On MRI, an acute lacunar infarct is shown as hyperintense on diffusion-weighted imaging (DWI),
[PDF File]Endothelial damage, vascular bagging and remodeling of the ...
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white matter have also been reported in human WMLs [15, 84, 89]. Further histopathological features of human WMLs include dilated perivascular Virchow-Robin spaces, loss of oligodendrocytes leading to demyelination, axonal damage and vacuolization (spongiosis) of the white matter, and potentially alterations in the density of so-called string
[PDF File]MEDICAL SCIENCE l ANALYSIS Medical Science Detectability ...
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atheromatous changes that likely result in chronic ischaemic changes of the WM (Wardlaw et al., 2013). The process is multifactorial and yet to be clearly understood. A typical general term describing this process is chronic white matter microangiopathy. However,
Cerebral Edema
The gray matter is affected first because of its high metabolic activity and greater astrocyte density. Ultimately, both the gray and white matter become involved, with corresponding loss A Fig. 1—Middle cerebral artery (MCA) infarct. A, Unenhanced CT image of early MCA infarct shows subtle edema in right lentiform nucleus, consisting
Neuropsychological Impairment Correlates With ...
known as cerebral microangiopathy (CMA),1,2 leading to lacunar infarctions (LI) and deep white matter lesions (DWML) that can be visualized with MRI. The cause of so-called vascular dementia is attributed mainly to the white matter lesions.3 It is assumed that microangiopathy causes damage of the periventricular white matter due to an uniden-
Veterinary Pathology Brain Lesions Associated With ...
microangiopathy in postneonatal cattle associated with the detection of epsilon toxin in the intestinal contents. ... whereas chronic and occasionally subacute cases ... Severe multifocal white matter rarefaction due to edema
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