Solid phase peptide synthesis steps
[DOC File]Solid-phase synthesis (SPS) or polymer-supported ...
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During solid-phase peptide synthesis, the aggregation of growing peptides on the resin due to hydrogen-bonded interactions, is thought to be the cause of ‘difficult’ sequences [11-14].
[DOC File]This is the title - ResearchGate
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Rink resin, Tentagel S RAM (theoretical loading: 0.25 mmol/g), was purchased from RAPP Polymere (Tübingen, Germany). Solid phase peptide synthesis was performed in plastic syringes with a polyethylene frit. Solution phase …
[DOCX File]Imperial College London
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As for most chemical transformations,10 by far the largest source of waste in either solution- or solid-phase peptide synthesis is the solvent, but only a few attempts have previously been made to avoid …
[DOCX File]ars.els-cdn.com
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Firstly, the chemistry should ensure each reaction proceeds to completion without side reactions. In the context of peptide, this goal can be achieved with the Fmoc chemistry from conventional solid phase peptide synthesis …
[DOCX File]Lecture 1: Key Concepts in Stereoselective Synthesis
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Solid-phase synthesis (SPS) or polymer-supported synthesis1-3 is a well-established synthetic method developed by Merrifield that has revolutionized peptide and oligonucleotide synthesis, drug …
Introduction to Peptide Synthesis
Solid phase peptide synthesis (SPPS) The development of SPPS by Merrifield revolutionized the field of peptide chemistry. Today, SPPS is acknowledged as the method of choice for creating peptides in …
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