Solid phase synthesis of peptides
Front Matter Template
Macromolecules, especially peptides up to 30-40 amino acids can reliably synthetized by solid phase peptide synthesis. Longer sequences can be accessed with fragment coupling methods. The first possibility is to couple partially protected peptide fragments followed by the removal of protecting groups.
[DOC File]Solid-phase synthesis (SPS) or polymer-supported ...
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Solid phase peptide synthesis (SPPS) The development of SPPS by Merrifield revolutionized the field of peptide chemistry. Today, SPPS is acknowledged as the method of choice for creating peptides in a synthetic manner.
[DOCX File]Technical Papers
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In 1959, Bruce Merrifield decided to investigate a new approach to peptide chemistry; one that would couple amino acids on solid support rather than in solution. Optimizing the conditions of this new approach would take Merrifield a few years, but the first solid phase synthesis …
[DOCX File]Lecture 1: Key Concepts in Stereoselective Synthesis
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Novel mild synthesis of diazonium ion intermediates for use with acid labile substrates, including the discovery and synthesis of a novel safety-catch linker for solid phase synthesis of cyclic peptides. Graduate Teaching Assistant, Purdue University, West Lafayette, IN, 2002.
[DOC File]Supporting Information
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Greening the Solid-Phase Peptide Synthesis Process. 2-MeTHF for the Incorporation of the First Amino Acid and Precipitation of Peptides after Global Deprotection O. Al Musaimi, Y. Jad, A. Kumar,A. El-Faham, J. Collins, A. Basso, B. de la Torre, F. Albericio, Org Proc Res Devel, 2019, under publication
Solid Phase Peptide Synthesis - Bachem
During solid-phase peptide synthesis, the aggregation of growing peptides on the resin due to hydrogen-bonded interactions, is thought to be the cause of ‘difficult’ sequences [11-14].
[DOCX File]Lecture 1: Key Concepts in Stereoselective Synthesis
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Fmoc solid-phase peptide synthesis was manually performed. The following side chain protected amino acids were used: Boc for Lys, Pbf for Arg, OBut for Asp and Glu, Trt for Asn, Cys, Gln and His, But for Ser, Thr, and Tyr. All peptides were prepared using Fmoc-based solid phase synthesis.
[DOC File]This is the title - ResearchGate
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Title: Solid-phase synthesis (SPS) or polymer-supported synthesis1-3 is a well-established synthetic method developed by Merrifield that has revolutionized peptide and oligonucleotide synthesis, drug discovery and is a key strategic component in combinatorial c
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