Solution phase peptide synthesis
Abstract - Universiteit Utrecht
Solid phase peptide synthesis (SPPS) The development of SPPS by Merrifield revolutionized the field of peptide chemistry. Today, SPPS is acknowledged as the method of choice for creating peptides in a synthetic manner. In the most common strategy the C-terminus of an amino acid (with protected side chain and N-terminus) is immobilized on a solid support (e.g. cross-linked polystyrene resin ...
[DOC File]This is the title - ResearchGate
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The peptides were produced with solution phase peptide chemistry with removal of acid-labile protecting groups using PGR and digital light directed synthesis. These experiments have led to a better understanding of the antibody binding site at the molecular level. The microscopic glass slides used in this experiment were prepared with piranha solution and treatment with 3 ...
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Solution-phase synthesis of building block 10 and characterization data (Scheme 1) S4 Solution-phase synthesis of Fmoc-(cis-4-N3)Pro-OH and characterization data. S16 Solid-phase synthesis procedures . S24 Crude RP-HPLC, MS, HRMS and NMR data for tetrapeptide 4·TFA (Scheme 2) S26 Crude RP-HPLC, MS, HRMS and NMR data for tetrapeptide 16 (Scheme 3) S28 Crude RP-HPLC, MS, HRMS …
[DOC File]Compound code
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80%B/0-40 min, mobile phase A was 20mM phosphate buffer solution, pH 7.0, mobile phase B was 20mM phosphate buffer solution (pH 7.0) containing 2M NaCl. synthesis of arginine-rich peptide conjugated oligonucleotide. The fragment condensation method of the conjugate of the peptide and the antisense oligonucleotide: The synthesis of the peptide. PAL resin (0.11mmol/g) and Fmoc-L-amino …
[DOCX File]eprints.whiterose.ac.uk
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Larger scale synthesis (appropriate for ca. 200 mg peptide) of the N-palmitoylated-PCSTSSMA (AP1032) employed solution-phase synthesis. This approach is a much less common method for preparing peptides, but was chosen as the preferred route for generating large quantities of AP1032; the detailed procedure is as follows. Step 1: PyBOP coupling. To a 0.2M solution of H-Ala-OtBu …
Peptide Synthesis, Custom Peptide, Peptide Coupling Reagents ...
Compared with solution phase peptide synthesis (
[DOCX File]Lecture 1: Key Concepts in Stereoselective Synthesis
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Its application to solid phase as well as solution phase peptide synthesis is also demonstrated and a mechanistic investigation is discussed. Boc-Oxyma (Ethyl 2-(tert-butoxycarbonyloxyimino)-2 ...
[DOCX File]Lecture 1: Key Concepts in Stereoselective Synthesis
https://info.5y1.org/solution-phase-peptide-synthesis_1_3e509f.html
Solid-phase synthesis (SPS) or polymer-supported synthesis1-3 is a well-established synthetic method developed by Merrifield that has revolutionized peptide and oligonucleotide synthesis, drug discovery and is a key strategic component in combinatorial c Author: Emma Last modified by: Cavalli G Dr (Chemistry) Created Date: 8/16/2013 1:00:00 PM
[DOC File]Solid-phase synthesis (SPS) or polymer-supported ...
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During solid-phase peptide synthesis, the aggregation of growing peptides on the resin due to hydrogen-bonded interactions, is thought to be the cause of ‘difficult’ sequences [11-14]. As a ...
[DOC File]Synthesis of masked aldehyde building blocks X-X+2
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As for most chemical transformations,10 by far the largest source of waste in either solution- or solid-phase peptide synthesis is the solvent, but only a few attempts have previously been made to avoid the use of DMF. Acetonitrile. G. A. Acosta, M. del Fresno, M. Paradis-Bas, M. Rigau-DeLlobet, S. Côté, M. Royo and F. Albericio, J. Pept. Sci ...
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