Srebp and lipid metabolism

    • Are SREBPs regulators of cholesterol/lipids as therapeutic targets?

      (2012) 7(1), 27–36ISSN 1758-429927 SpecialRepoRt SREBPs: regulators of cholesterol/lipids as therapeutic targets in metabolic disorders, cancers and viral diseases The ability to store excess calories as lipids has pro- vided an evolutionarily selected advantage, allow- ing organisms to survive during periods of food limitation.

    • What are SREBPs and why are they important?

      Aberrant SREBP activities have been linked to conditions associated with metabolic syndrome, including insulin resistance, obesity, elevated circulating LDL-C and triglycerides, and nonalcoholic fatty liver diseases. In addition, SREBPs have

    • What is the role of SREBP in the pathogenesis of cancer?

      In addition, SREBPs have been implicated in cancer cell proliferation and enveloped viral replication through regulation of membrane synthesis. Therapeutic approaches to block SREBP functions linked to disease states may act through potentiation of SREBP

    • What is lipid homeostasis and how does it work?

      At the most basic level, lipid homeostasis is a product of the balance between dietary intake, de novoproduction and degradation/utilization. Lipid production depends on the levels of acetyl- CoA, which is produced by the tricarboxylic acid cycle. Acetyl-CoA is used as the starting point to generate the array of fatty acids incorporated into

    • The phosphorylation-dependent regulation of nuclear SREBP1 ...

      The SREBP transcription factors are major regulators of lipid metabolism. Disturbances in lipid metabolism are at the core of several health issues facing modern society, including cardiovascular disease, obesity and diabetes. In addition, the role of lipid metabolism in cancer cell growth is receiving increased attention.

    • [PDF File]SREBPs: metabolic integrators in physiology and …

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      SREBP-1c isoform has a much weaker activation domain. SREBP-2 has a strong activation domain similar to that of SREBP-1a. SREBP-1c is the predominant isoform in most adult non-dividing metabolic tissues such as liver and adipose. The SREBP-1c promoter is autoregulated by SREBPs [3] and stimulated by both liver X receptor (LXR) and insulin ...

    • SREBPs: SREBP function in glia–neuron interactions

      known to regulate lipid metabolism in liver and adipose tissue. The SREBP family consists of SREBP-1a, SREBP-1c and SREBP-2 [1]. SREBP-1c and SREBP-2 preferentially govern the upregulation of genes involved in fatty acid and cholesterol metabo-lism, respectively, whereas SREBP-1a activates both pathways [1,2]. SREBP-1a is expressed ubiquitously at

    • Zinc mediates the SREBP-SCD axis to regulate lipid ...

      SREBP-2 by cholesterol (6), SREBP-1 by PC (7), and Drosoph-ila (d)SREBP by phosphatidylethanolamine (27), it is still arguable that other unknown factors may participate in the SREBPs’ regulation of lipid metabolism. The activities and functions of SREBPs in lipid metabolism are highly evolu-tionarily conserved across metazoans. The model ...

    • SREBPs: regulators of cholesterol/lipids as therapeutic ...

      SREBPs control genes involved in cholesterol/lipid metabolism, membrane synthesis and fat storage. Aberrant SREBP activities have been linked to conditions associated with metabolic syndrome, including insulin resistance, obesity, elevated circulating LDL-C and triglycerides, and nonalcoholic fatty liver diseases. In addition, SREBPs have

    • [PDF File]SREBPs in Lipid Metabolism, Insulin Signaling, and …

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      required for lipid synthesis and uptake [18]. SREBP-1a and SREBP-1c preferentially activate transcription of genes required for FA and triglyceride synthesis, including acetyl-coen-zyme A (CoA) carboxylase, FA synthase, stearoyl-CoA desaturase, and glycerol 3-phosphate acyltransferase. Bycontrast,SREBP ...

    • [DOC File]Table 2 - ResearchGate

      https://info.5y1.org/srebp-and-lipid-metabolism_1_2b41b0.html

      SREBP-2. Transcription factor, WD repeat. HMG box transcription factor, transcriptional repressor, role in cell fate decisions ... triacylglycerol lipase, lipid metabolism. C2H2 Zinc finger. JNK ...

    • [DOC File]Universitetet i oslo

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      SREBP transcription factors - regulators of cholesterol and fatty acid metabolism. Lecturer: Post.Doc. Fred Haugen. TOPIC 3: Lipid droplet-associated proteins. Lecturer: Post.Doc. Knut Tomas Dalen . Responsible: Hilde Nebb/Knut Tomas Dalen. Teacher: Engineer Borghild Arntsen TOPIC 1. NUCLEAR RECEPTORS IN CONTROL OF GLUCOSE AND LIPID HOMEOSTASIS

    • [DOC File]Microsoft

      https://info.5y1.org/srebp-and-lipid-metabolism_1_d6e8b2.html

      This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the ...

    • [DOC File]2005-04-25

      https://info.5y1.org/srebp-and-lipid-metabolism_1_21b752.html

      Among the three microRNAs, miR-122 is the most studied in NAFLD and can regulate numerous genes involved in lipid metabolism, such as sterol regulatory element binding protein (SREBP), acetyl coenzyme A carboxylase 2 (ACC2), and 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR)[23,24].

    • [DOCX File]C O N T E N T

      https://info.5y1.org/srebp-and-lipid-metabolism_1_956ea9.html

      Dietary fat and endogenous lipid synthesized in the liver must be transported between tissues and organs to be metabolized there. This plasma transportation is provided by water soluble macromolecules: lipoproteins. Lipoprotein metabolism abnormalities are a major cause of …

    • [DOC File]NISCAIR PROJECT: E-book/ Zoology

      https://info.5y1.org/srebp-and-lipid-metabolism_1_4a1a89.html

      Lipid metabolism provides cells with energy fuels, energy stores, membrane constituents and signaling molecules. Lipids are transported in the blood either in the free form as fatty acids and ketone bodies, or in the bound form within hydrophilic, lipoprotein complexes.

    • [DOC File]Journal of Cancer

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      Lipid metabolism are altered in rapidly proliferating cells, which synthesize lipids through de novo lipogenesis5-7. Continuous de novo lipogenesis provides cancer cells with membrane building blocks, signaling lipid molecules and post-translational modifications of proteins to …

    • [DOC File]Journal of Cancer

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      Under normal situations, SREBP and SREBP cleavage-activating protein (SCAP) form the composites in endoplasmic reticulum, and SREBP enters into the nucleus after cells are excited by stimulus signals. Meanwhile, the expressions of ACLY, ACC and FASN are regulated. Inhibiting pathways of lipid metabolism might be an alternative treatment for ...

    • [DOC File]Hindawi Publishing Corporation

      https://info.5y1.org/srebp-and-lipid-metabolism_1_b36f49.html

      22056139 Regulation of lipid metabolism_Regulation of lipid metabolism via LXR, NF-Y and SREBP 2.40E-03 4.56E-02 4/38 miR-532-3p,miR-155 NA Immune response_IL-15 signaling 2.64E-03 4.85E-02 5/64 miR-30e,miR-126, let-7g,miR-621 26275688 Immune response_CD40 signaling 2.82E-03 4.89E-02 5/65 miR-126,miR-621,miR-346, let-7g

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