Statin associated autoimmune myopathy
[DOCX File]Specialist Working Group for Neurology - Blood
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Alcoholics should be closely followed after using statins. Cholestasis can delay the excretion of statins, and increased plasma concentrations of statins may increase the risks of statin-induced myopathy (SIM). In addition, a history of statin drug allergy in SIM patients should also preclude the use of statins [71].
[DOCX File]University of Manchester
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Necrotizing autoimmune myopathy typically has necrotic myofibres with less inflammatory infiltrate and the absence of direct myocyte invasion by lymphocytes. These disorders are acquired and have in common the occurrence of significant muscle weakness and the presence of an inflammatory response within the muscle.
Statin-associated autoimmune myopathy - Wikipedia
However, although these factors have been associated with statin-induced myopathy, their association with statin-induced autoimmune myositis remains unclear. Epidemiology : Autoimmune myositis is rare, with an estimated prevalence of 22 in 100,000 (20) and statin-induced autoimmune myositis is rarer still, with a prevalence of 1 in 100,000 (21).
[DOC File]University of Pittsburgh
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The patient has the features of a statin-induced immune-mediated necrotizing myopathy (IMNM), recently described as being associated with the anti-HMGCR antibody. First-line immunotherapy with glucocorticoids is appropriate while further investigations are undertaken, although many cases of IMNM ultimately require more aggressive immunotherapy.
[DOC File]International Journal of Biological Sciences
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In this review, we will update the epidemiology of IIMs, and statin myopathy which is a common form of myopathy associated with medications. Adult polymyositis (PM) and adult dermatomyositis (DM) The estimated combined annual incidence of adult PM and DM in the general population is approximately 2 per 100,000 persons [1].
[DOCX File]Title: Statin Induced Autoimmune Myopathy
https://info.5y1.org/statin-associated-autoimmune-myopathy_1_a26526.html
Reduced levels are associated with fatigue, and the greatest impact occurs in high energy producing tissues, such as muscle and the liver. Statin-induced myopathy has been associated with low CoEQ10 levels (Banach et al 2014), but research into the impact of CoEQ10 supplementation has failed to demonstrate improved tolerance.
[DOCX File]Hawkes N (2017). NICE guidelines could put 12 million UK ...
https://info.5y1.org/statin-associated-autoimmune-myopathy_1_8ac6f0.html
Necrotizing autoimmune myopathy typically has necrotic myofibres with less inflammatory infiltrate and the absence of direct myocyte invasion by lymphocytes. ... NAM is often associated with a history of statin exposure, and the presence of autoantibodies against HMG coenzyme reductase, or other muscle antigens. Diagnostic criteria have been ...
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