Statins and myalgias
[DOCX File]Date
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Statins block an intermediate in the production of coenzyme Q10. This has prompted the hypothesis that, because mitochondria are involved with muscle function, statin-induced coenzyme Q10 deficiency contributes towards statin-associated myopathy. ... 76 patients receiving statin therapy and experiencing myalgias, either generalised or in ≥2 ...
[DOCX File]Title: Statin Induced Autoimmune Myopathy
https://info.5y1.org/statins-and-myalgias_1_0a478f.html
Explain from a pathophysiological perspective the difference in mechanism of action between a hydrophilic and lipophilic statin as they relate to myalgias. As an FNP, how does this knowledge help you? Give two examples of hydrophilic and lipophilic statins.
[DOCX File]Pharmacy Benefits Management Services Home
https://info.5y1.org/statins-and-myalgias_1_9766d3.html
In the original clinical trials of statins, myalgias and/or myopathic problems were not identified as common adverse events, with only 1-5% of participants reporting muscle-related side effects in both intervention and placebo groups(3,4). However, subsequent observational studies have estimated a higher incidence of muscle complaints, ranging ...
[DOC File]STATIN-FIBRATE REPORT: Focus on Safety
https://info.5y1.org/statins-and-myalgias_1_b26651.html
Nov 12, 2013 · Although the risk for serious adverse events related to statins is low, other less severe adverse events such as muscle complaints (e.g., myalgias) occur more commonly with higher intensity statins and may lead to decreased adherence and reluctance to continue statin therapy. Therefore, the potentially increased risk for adverse events from ...
UKMi Q&A xx - SPS
Adverse effects associated with statins are: Myalgias, muscle cramp, liver enzyme derangements, changes in memory, concentration and mood, polyneuropathy, acute renal failure. Fibrates : These are derivatives of fibric acid (isobutyric acid),these include the following drugs gemfibrozil, bezafibrate, fenofibrate, clofibrate, dextrothyroxium ...
[DOCX File]UPX Material - University of Phoenix
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According to these two articles, statins are the most effective lipid lowering agent and are the most commonly used prescription medication to lower lipid levels despite their adverse effects. However, there is not a specific treatment regime for those patients who develop myalgias …
UpToDate
The dose of fenofibrate was approximately 200 mg daily. In many cases, statins were used in combination with the fibrates but the dose of the statin was maintained throughout the study period. ... (0.12%) and 33 (1.9%) developed other muscle-related symptoms including myalgias, myositis, muscle weakness or musculoskeletal pain. Finally ...
[DOC File]ENCLOSURE-I
https://info.5y1.org/statins-and-myalgias_1_25c707.html
When statins are used alone the risk of myopathy is small but when certain drugs are added the risk increases. Niacin, fibrates, imidazoles, macrolides and protease inhibitors may increase the risk of myopathy. Patients who develop myalgias or muscle weakness should …
[DOCX File]ND Center for Nursing
https://info.5y1.org/statins-and-myalgias_1_f6e229.html
Initial: Three cases must be documented and reviewed with Champion each week for one month; followed by 3 cases per month for 3 months; then 6 cases per year. Nurse must demonstrate appropriate management of patients on statins. If primary care provider disagrees with management plan, cases will be reviewed with Champion.
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