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[PDF File]Appendix 10: Administering drugs via feeding tubes
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formulation, may alter bio-availability and/or block the tube.7,9,10 M/r preparations (including m/r coated capsule contents) as this may cause dangerous dose peaks and troughs.3,7,10 Cytotoxics, prostaglandin analogues, hormone antagonists or antibiotics as there are risks to the staff through inhalation and/or topical absorption.3,7,10

Model Bioequivalence Data Summary Tables
Guidances/UCM292334.pdf ) 2 These summary tables provide a standard format for data to be submitted to the Office of Generic Drugs in accordance with current recommendations. Please note that the ...

[PDF File]MOC GUIDELINES FOR TABLET CRUSHING - St Catherines
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MOC GUIDELINES FOR TABLET CRUSHING IN PATIENTS WITH SWALLOWING DIFFICULTIES Please follow the guidelines in order, as shown in the chart (i.e. number 1 is the preferred choice of which form to administer the drug in). KEY TO DRUG ADMINISTRATION GUIDELINES A Tablet will disperse in 1-2 minutes. B Tablet will disperse in greater than 2 minutes.

[PDF File]Singulair (Montelukast Sodium)
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to the 4-mg chewable tablet, it can also be used as an alternative formulation to the 4-mg chewable tablet in pediatric patients 2 to 5 years of age. Drug Interactions . Montelukast at a dose of 10 mg once daily dosed to pharmacokinetic steady state: • did not cause clinically significant changes in the kinetics of a single intravenous dose of theophylline (predominantly a cytochrome P450 ...

[PDF File]HIGHLIGHTS OF PRESCRIBING INFORMATION Pugh A), the ...
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The recommended dosage of EPCLUSA in adults is one tablet (400 mg sofosbuvir and 100 mg velpatasvir) taken orally once daily with or without food [see Clinical Pharmacology (12.3)]. When administered with EPCLUSA, the recommended dosage of ribavirin is based on weight (administered with food): 1,000 mg per day for patients less than 75 kg and 1,200 mg for those weighing at least 75 kg, …

[PDF File]WELLBUTRIN SR - Food and Drug Administration
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WELLBUTRIN SR® (bupropion hydrochloride) Sustained-Release Tablets 4 significant difference in C max, half-life, t max, AUC, or clearance of bupropion or its active metabolites between smokers and nonsmokers. CLINICAL TRIALS: The efficacy of the immediate-release formulation of bupropion as a treatment for depression was established in two 4-week, placebo-controlled trials in adult inpatients

Generic Drugs and Bioequivalents
Formulation Data. Components 150 mg (mg/tab) 300 mg (mg/tab) Core Components. Active, USP. 166.65 (71.21%) 333.3 (71.21%) Ethyl Cellulose, NF; 15.8 (6.75%) 31.6 (6.75%) Alginic Acid, NF. 20.0 (8 ...

[PDF File]Assistant Director, Drug Information Service Me d ic at ...
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This dosage formulation prevents destruction of the drug by stomach acid, reduces GI irritation, and allows for a delayed onset of action. Examples of enteric-coated medications include aspirin (Ecotrin®), bisacodyl (Dulcolax®), and du-loxetine (Cymbalta®). Crushing enteric-coated products could affect the drug’s efficacy as well as increase the risk of GI toxicity. Furthermore, enteric ...

[PDF File]Comparison of Long-Acting Diltiazem Formulations in Canada ...
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Tablet is smaller than either Cardizem® CD or Tiazac® capsules. Capsule is smaller than equivalent strength Cardizem® CD.1 This formulation is marketed as providing better P control during the ‘morning P surge’, though BP is the only outcome data available.7 Least expensive formulation.3

[PDF File]Table 1: Dosing Regimen of H2RAs and Proton Pump ...
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∗∗ This product is now covered by Medicaid in its OTC formulation by prescription only. It is generally the least expensive alternative and use is encouraged when appropriate. H2RAs for 10 days rabeprazole²PPIs Footnotes: 1. Dosage adjustments should be made for impaired renal function 2. Dosage adjustments should be made for hepatic insufficiency 3. Dual therapy can be prescribed ...

Tablet formulation pdf