Thiazide diuretics calcium
[PDF File] Calcium - The Lancet
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Thiazide diuretics increase renal calcium reabsorption, which resolves with discontinuation of the medication. Immobilisation, notably in younger patients, may lead to a rapid increase in bone resorption and hypercalcaemia especially in the presence of renal insufficiency. Granulomatous diseases such as sarcoidosis,
[PDF File] Diuretics for Hypertension: A Review and Update
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blockers, and calcium channel blockers by 4.2–6.2 mm Hg SBP.18,35 HCTZ was less effective in preventing CVEs com-pared to enalapril in the ANBP2 trial, to amlodipine in the ... channel blockers; PSDs: potassium-sparing diuretics; thiazide type, thi-azide and thiazide-like diuretics. Table 1. The latest guidelines and thiazide-type diuretics
[PDF File] Thiazide Diuretic Dose and Risk of Kidney Stones in Older …
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thiazide diuretics, kidney stones, hydrochlorothiazide, dose Received February 7, 2018. Accepted for publication May 17, 2018 What was known before Prior studies found that higher dose thiazide diuretics lower urinary calcium excretion to a greater degree than lower dose thiazides. Whether or not this translates into a difference in
[PDF File] my urine calcium. How does it work?” Hypercalciuria - Labcorp
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my urine calcium. How does it work?” Common, generic diuretics called thiazide (i.e. hydrochlorothiazide, chlorthalidone) which were originally designed to remove sodium and water from the body and lower blood pressure have a special value to stone formers with hypercalciuria. This type of drug lowers urine calcium, and prevents stones from ...
[PDF File] Thiazide-Type Diuretics: Ongoing Considerations on …
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ECF VOLUME CHANGES WITH THIAZIDE-TYPE DIURETICS. The precise means by which a thiazide-type diuret-ic lowers BP is undecided. The effect of a thia-zide diuretic on BP may be separated into three chronological phases: 1) acute; 2) subacute; and 3) chronic, which correspond to periods of roughly 1–2 weeks, several weeks, and several months ...
[PDF File] Thiazide diuretics and primary hyperparathyroidism
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Thiazide diuretics exert a natriuretic and diuretic effect by inhibiting sodium reabsorption in the distal convoluted tubule. Furthermore, thiazide diuretics affect renal calcium handling by increasing calcium reabsorption, leading to hypocalciuria. The effect that thiazide diuretics exert on parathyroid hormone secretion is controversial. Some
[PDF File] Structure of human NCC: insights into the inhibition …
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(a thiazide diuretic) inhibits NCC mainly by two mechanisms: (1) it competes with the Cl − for the same binding site; (2) it prevents isomerization of the NCC from the outward-facing to inward-
[PDF File] A REVIEW ON THIAZIDE DIURETICS AND β-BLOCKERS CAUSING
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Thiazide-type diuretics are advised as first-line therapy for the management of hypertension, although their usage has been constrained due to unfavourable metabolic effects, such as hyperglycemia ...
[PDF File] Thiazides diuretics in the treatment of nephrolithiasis: are
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evidence-based doses to prevent calcium-containing kidney stone recurrence. This may be the result of a combination of factors including: a practice pattern of using lower doses of hydrochlorothiazide for the treatment of hypertension that has carried over to the treatment of stone disease and/or a lack of knowledge of RCT of thiazide diuretics ...
[PDF File] The mechanism of hypocalciuria with NaCl cotransporter …
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Thiazide diuretics reduce urinary calcium excretion to about 50–60% of pre treatment levels. The effect of thiazide on calcium excretion is reported to begin within
[PDF File] Prescribing cascades of antigout medications from thiazide …
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thiazide diuretics in hypertension management are associated with an increased prescribing cascade of antigout agents among rst-line antihypertensive medications. Materials and methods
[PDF File] COMPARATIVE EFFECTIVENESS OF THIAZIDE DIURETICS …
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antihypertensive medications are thiazide diuretics and calcium channel blockers. Thiazide diuretics act by promoting diuresis and decreasing blood volume, thereby reducing blood pressure.[6] Calcium channel blockers, on the other hand, relax blood vessels by blocking calcium entry into cells, leading to reduced blood pressure.[7]
[PDF File] Diuretics and Disorders of Calcium Homeostasis - Seminars in …
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Thiazide diuretics block the thiazide-sensitive NaCl transporter in the distal convoluted tubule, and can decrease calcium excretion. They are often used in the treatment of nephrolithiasis. Carbonic anhydrase inhibitors decrease bicarbonate absorption and the resultant metabolic acidosis can increase calcium excretion. Their use can
[PDF File] Effects of Thiazide-Type and Thiazide-Like Diuretics on …
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The primary objective of this systematic review and meta-analysis was to compare the effect of TT and TL diuretics on CVE, coronary events, heart failure, cerebrovascular events, and all-cause mortality in adult hypertensive (BP >140/90 mm Hg) patients. Data Sources and Searches. In this meta-analysis, we adhered to PRISMA (Preferred Reporting ...
[PDF File] Thiazide Diuretics and Calcium Metabolism
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Thiazide diuretics reduce urinary ex- cretion of calcium by about 400/o in patients with intact parathyroid glands (normal parathyroid function or pri- mary hyperparathyroidism). Despite equivalent sodium losses, thiazide diuretics do not lower calcium excre- tion in patients with hypoparathyroid- ism.
[PDF File] Thiazide Diuretic Prophylaxis for Kidney Stones and the Risk …
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Those who received thiazide diuretics were more likely to have a known calcium compo-nent of the stones than those who did not receive thiazide diuretics. There were 163 DM events during followup. The risk of DM was increased among incident stone formers who had prevalent or new onset hyperten-sion, received thiazide diuretics, were older, were
[PDF File] Diuretics .edu
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Thiazide diuretics Potassium-sparing diuretics - -- Loop of Henle @ Carbonic anhydrase inhibitors (acetazolamide) t NaHC0 3 excretion @ Osmotic diuretic (mannitol) t H 2 ... Promotes calcium phosphate stone formation Increased urinary pH increases excretion of organic acid anions and decreases excretion of weak organic bases.
[PDF File] Efficacy and Safety of Calcium Channel Blocker/Diuretics …
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thiazide (-like) diuretics, have remained in reserve, even if the clinical evidence has shown that this combination is at least as efficient as the above-mentioned treat-ment,6–10 and the new American and European guide-lines on hypertension consider the CCB/thiazide (-like) diuretic combination as one of the preferred drug
[PDF File] Prevention of calcium stones with thiazides - Kidney …
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The initial rationale for the use of thiazides in. stone prevention was based on the observation that thiazide diuretic therapy resulted in reduced urinary. excretion of calcium, an effect first reported by Lam-. berg and Kuhlback in 1959 [1] and subsequently. confirmed by a number of investigators [2—51. The.
[PDF File] Diuretics in the treatment of hypertension - Springer
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Other types of diuretics (e.g., loop, potassium sparing) may be useful for the treatment of hypertension related to chronic kidney disease (CKD) and other varied conditions. Common side effects of thiazides are mostly dose-related and involve elec-trolyte and metabolic abnormalities. Keywords Hypertension .
[PDF File] Diuretics for hypertension: Hydrochlorothiazide or …
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Thiazide diuretics are the cornerstone of treatment of hypertension in most patients. Hydrochlorothiazide is the most commonly used thiazide diuretic in the United States, but interest in chlorthalidone is increasing. The authors summarize the literature comparing these two agents.
[PDF File] DRUG CLASSES THIAZIDE AND THIAZIDE-LIKE DIURETICS
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Thiazide-like Chlortalidone Indapamide Mechanism of action Thiazide and thiazide-like diuretics act on the nephron mainly at the proximal part of the distal tubule. Sodium excretion and urine volume are increased by interference with transfer across cell membranes. The result is a reduction in blood volume. However,
[PDF File] Thiazide and Loop Diuretics - Wiley Online Library
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thiazide-type diuretic therapy. • Diuretics can be successfully combined with b-block-ers, angiotensin-converting enzyme inhibitors, angioten-sin receptor blockers, centrally acting agents, and even calcium channel blockers. • Although thiazide-type diuretics are among the best-tol-erated antihypertensive agents in terms of symptomatic
[PDF File] Kidney Stones: Treatment and Prevention - AAFP
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be recommended for all patients, and thiazide diuretics, allopurinol, or citrates should be prescribed for patients with recurrent calcium stones. Patients at high risk of stone recurrence should ...
[PDF File] Diuretics and the kidney - BJA Education
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ion homeostasis (Naþ,Kþ, HCO 3 e and calcium ions [Ca2þ]). Around 5e10% of the filtered Naþ is reabsorbed in the DCT, predominantly via the thiazide-sensitive Naþ/Cle symporter, which reabsorbs Naþ and Cle ions from tubular fluid.3 Aldo- sterone, produced in the adrenal cortex in response to low
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