Thyroid hormone pathway

    • [DOC File]Endotext.com - Thyroid Disease Manager

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      A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels. Eur J Endocrinol. 2011 May;164(5):781-8. 65. Porcu E, Medici M, Pistis G, Volpato CB, Wilson SG, Cappola AR et al. A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

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    • [DOC File]Biochemistry Diseases (Chapters 27-52)

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      Graves Disease – autoimmune production of thyroid stimulating IgG (TSI). TSI activates the TSH receptor that causes uncontrolled production of T3/T4. Leads to exophthalmos, optic nerve degradation, and periodic paralysis. Treat by blocking hormone production with anti-thyroid drug or ablate thyroid with radioactive Iodine.

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    • [DOC File]Biochemistry Objectives 46

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      TRH: Thyroid releasing hormone stimulates thyrotrophic release of TSH via Gq and the IP3/DAG/Ca2+ pathway. TSH: thyroid stimulating hormone . T4 activation to T3 in peripheral target cells: T4 is brought into the cell by passive diffusion when bound to TBG, and is converted to the more metabolically active T3 form by 5’ deiodinase. 4.

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    • [DOC File]Introduction to Section II

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      One of the primary mechanisms by which the thyroid hormone pathway increases metabolic rate is . increased insertion of Na+/K+-ATPase into cell membranes. increased shivering. increased fatigue. increased growth. increased breakdown of proteins.

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    • [DOC File]Thyroid Hormones

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      10% of hyper thyroid patients have one or more small benign tumors in their gland (hot nodules), which make hormone at too high a rate. This is called toxic nodular goiter or plummer’s disease. Treatment: In the short term it may focus on making the body less responsive to the stimulus given by the thyroid hormone (beta blockers).

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    • [DOC File]Genetic Defects in Thyroid Hormone Synthesis and Action

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      3. Defects in thyroid hormone synthesis (dyshormonogenesis) In about 15% of cases, CH is due to hormonogenesis defects caused by mutations in genes involved in thyroid hormone synthesis, secretion or recycling. These cases are clinically characterized by the presence of goiter, and the molecular mechanisms have been well defined.

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    • [DOC File]Introduction to Section II - Creighton University

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      The following questions relate to the thyroid hormone pathway. Describe or diagram the pathways controlling the release of the thyroid hormones. Be sure to give the full names of the all hormones, including the two hormones released by the thyroid gland. You do not need to discuss the specific effects of thyroid hormone on body tissues.

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    • [DOC File]Anatomy Chapter 20: Endocrine System

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      The thyroid gland has what coloration and why? Regulation of thyroid hormone secretion depends upon what feedback process? What are small, brownish-red glands located on the posterior surface of the thyroid gland. How many parathyroid glands do humans have? What are the two types of cells found in the parathyroid glands?

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