Thyroid hormone synthesis pathway
Bio-Sketches of
Thyroid hormone synthesis, plasma membrane transport, and metabolism.1997. 184. Brouwer A, Morse DC, Lans MC, Schuur AG, Murk AJ, Klasson-Wehler E, et al. Interactions of persistent environmental organohalogens with the thyroid hormone system: mechanisms and possible consequences for animal and human health.
[DOC File]Endotext.com - Thyroid Disease Manager
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The pump can be blocked by anions like percholate and thiocynate, which compete with iodine. Large amounts of iodide with also inhibit the pump and thyroid hormone synthesis (Wolff-Chaikoff effect). Iodine ions are oxidized to iodine by peroxidase located on the apical membrane. Iodine is capable of combining with the amino acid tyrosine.
[DOC File]Genetic Defects in Thyroid Hormone Synthesis and Action
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Effect of Triclosan,Triclocarban, 2,2',4,4'-Tetrabromodiphenyl Ether, and Bisphenol A on the Iodide Uptake, Thyroid Peroxidase Activity, and Expression of Genes Involved in Thyroid Hormone Synthesis
Thyroid Hormone Synthesis - an overview | ScienceDirect Topics
3. Defects in thyroid hormone synthesis (dyshormonogenesis) In about 15% of cases, CH is due to hormonogenesis defects caused by mutations in genes involved in thyroid hormone synthesis, secretion or recycling. These cases are clinically characterized by the presence of goiter, and the molecular mechanisms have been well defined.
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