Titration of propofol
[DOC File]Propofol Dosing Guidelines
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Heena Parikh and colleagues studied on the utility of bispectral index for titration of propofol dosages and recovery from anaesthesia on 100 patients and concluded that propofol consumed in group who received standard dose of 1.5mg/kg is 2.24 mg/kg whereas its 1.60mg/kg in the group who received a titrated dose of propofol until a BIS value of 45-60 is reached and recovery is 60% in group who ...
[DOC File]APPENDIX 1 - Lippincott Williams & Wilkins
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High dose propofol (> 50 mcg/kg/minute for > 48 hours) may cause propofol infusion syndrome. Propofol related infusion syndrome (PRIS) is characterized by metabolic acidosis, hypotension, bradyarrhythmias, lipemia, rhabdomyolysis, and cardiac failure. If suspect PRIS, propofol should be stopped immediately and an alternative sedative agent be ...
[DOC File]RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,
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Propofol (Diprivan) infusion (1000mg in 100ml ) as ordered . Start infusion at 5mcg/kg/minute. Titrate to a . RASS -1 to -2. and . BIS Goal . below 50 . Continuous Infusion: max rate of 50 mcg/kg/min - automatic stop after 48 hours. Titrate Method: Frequency of rate change by 5mcg/kg/minute every 20 minutes . OR. Versed(Midazolam) infusion ...
[DOC File]Pharmacokinetics and Pharmacodynamics
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Titration: Start at 5 mcg/kg/min and titrate up to 9 mcg/kg/min until desired level of paralysis is achieved (1 or 2 twitches on TOF) Maintenance Rates: Usual is 5 – 9 mcg/kg/min Standard Drip: 200 mg in 100 ml of NS or D5W prepared by pharmacy; withdraw an equal amount of diluent from bag equal to volume of drug to be added.
[DOC File]Central Maine Medical Center
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Liu N, Chazot T, Trillat B, Pirracchio R, Law-Koune JD, Barvais L, Fischler M. Feasibility of closed-loop titration of propofol guided by the Bispectral Index for general anaesthesia induction: a prospective randomized study. Eur J Anaesthesiol. 2006;23:465-9 Diprifusor …
[DOCX File]www.nyspfp.org
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Reduce Propofol rate in half. If after 30 minutes patient is still not overly agitated or delirious stop the Propofol drip. If patient becomes agitated or delirious after reducing the drip in half: Increase by 5 mcg/kg/min every 5 minutes to goal level of sedation (standard titration parameter) up …
[DOCX File]www.myharrisregional.com
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Propofol – Start infusion at 10 mcg/kg/min; For titration: Increase rate by 10 mcg/kg/min (May titrate infusion every 5 mins) for RASS -4; Notify provider if infusion rate is 50 mcg/kg/min OR for 5 rate increases in 24 hours; Check Triglyceride level according to Code Cool Firstnet PowerPlan (or similar orderset if not using Cerner).
[DOC File]Lippincott Williams & Wilkins
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The model with the best fit both numerically and graphically was chosen as the revised pharmacokinetic model for propofol derived from the learning group. This pharmacokinetic model was then incorporated into the STANPUMP software running the infusion pump system to administer propofol to the test group using the same propofol titration and ...
[DOC File]Carolinas Medical Center – MERCY
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The propofol concentration at the effect site must decrease by 50%, while the alfentanil concentration decreases by 25-35%. Figure 20: “Optimal” propofol/remifentanil anesthesia, showing change towards higher opioid and reduced propofol doses. ... How will remifentanil change titration? One possibility is that titration may become totally ...
Diprivan (propofol) dose, indications, adverse effects ...
D. Titrate the propofol infusion rate, not the ketamine infusion rate. If the patient seems to require a lot of propofol, give 25-50 µg fentanyl boluses. F. As with propofol, the ketamine infusion rate was designed for adults of average weight (60-80 kg). Adjust upward or downward for larger or smaller patients.
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