Toxicity testing on animals

• [PDF File]SUB-CHRONIC ORAL TOXICITY TESTING IN LABORATORY …

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  duction of animal testing in the U.S. in the 1920's was a major advance in toxicity testing, and subsequent de­ bates about the place of animals in testing were qualified by the absence of better alternatives. In the past decade the issue of whole-animal toxicity testing has be­ come more urgent and contentious. Animal-welfare advocates have de­

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• [PDF File]Basic Overview of Preclinical Toxicology Animal Models

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  34260 Federal Register/Vol. 64, No. 122/Friday, June 25, 1999/Notices This guidance represents the agency’s current thinking on the duration of chronic toxicity testing in animals (rodent and ...

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• The use of animals in toxicity testing

  TOXICITY TESTING REQUIREMENTS, METHODS AND PROPOSED ALTERNATIVES Megan Erin Gallagher* I. INTRODUCTION Toxicology is the study of chemical substances that harm biological organisms.' Toxic exposure can occur transdermally through contact with the skin, orally and via inhalation.2 Toxicity testing is necessary to

  alternatives to animal testing articles

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• [PDF File]Chapter

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  SUB-CHRONIC ORAL TOXICITY TESTING IN LABORATORY ANIMALS 1. INTRODUCTION 1.1. Objective of the Guidance In the assessment and evaluation of potential toxic characteristics of feed substances, sub-chronic toxicity studies in rodents are typically carried out for a …

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• [PDF File]Toxicity Testing Requirements, Methods and Proposed ...

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  9.2 In the second part of the chapter we discuss a range of welfare implications that may arise for animals involved in toxicity testing. We consider first effects that may result from the dosing and sampling methods that are commonly used, and then effects related directly to the toxicity of the chemical that has been administered.

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• Testing - American Anti-Vivisection Society

  Toxicity Testing in the 21st Century: A Vision and a Strategy Advances in molecular biology, biotechnology, and other fields are pav- ing the way for major …

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• [PDF File]Toxicity Testing in the 21st Century: A Vision and a Strategy

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  The use of animals in toxicity testing: An RSPCA information paper RSPCA policy The RSPCA is opposed to all experiments or procedures that cause pain, suffering, distress or lasting harm to animals.

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• Alternatives to Animals in Toxicity Testing

  • Repeat Dose Toxicity • Extensive evaluations of toxic effects •Body weights •Clinical signs of toxicity •Food consumption •Clinical pathology •Histopathology •Other • Large animals usually undergo more extensive evaluation (e.g., ECGs) • At least one dose should produce dose-limiting toxicity.

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