Treating statin induced myopathy
[DOC File]Pharmacy Benefits Management Services Home
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3. Myopathy. can be caused by corticosteroids, or by antihyperlipidemics i.e. “statin” drugs. 4. Corticosteroids . used for many systems: pulmonary, rheumatology, dermatology, etc. suppression of the body’s immune response may be the therapeutic intent (post organ transplant, rheumatologic disease), or it may be an adverse effect
[DOC File]Geriatric Assessment Tool Kit
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Over 2 million new (within the previous year) statin users without chronic CKD and 59,636 with CKD were identified. Patients with chronic CKD were at higher risk of admission to hospital with AKI in the first 6 months after statin initiation [10 to 63 per 1000], compared with those without CKD [1 to 3.5 per 1000] ().
[DOC File]SPS
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Moreover, Statin-induced myopathy is caused by the long-term use of higher doses, when certain drugs have been used previously (cyclosporine, erythromycin and clarithromycin), we should be fully aware of toxic side effects and other drug …
[DOCX File]Hawkes N (2017). NICE guidelines could put 12 million UK ...
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It should be noted that none of these trials3-7 (comparing a high dose to a moderate dose statin) used a “treat to target” LDL-C lowering approach since statin doses were not titrated based upon LDL-C with the exception of IDEAL in which patients were permitted in a nonrandomized fashion to increase their simvastatin dose from 20 to 40 mg ...
[DOC File]UKMi Q&A xx - SPS
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Side effect such as statin-induced myopathy (muscle damage) and rhabdomyolysis (muscle destruction) are a major concern, but the potential benefit of perioperative statin therapy appear to outweigh the risk of potential hazard. Therapy should be initiated a few days before surgery in combination with dose adjustment for tight heart rate control.
Statin-induced myopathies
The mechanism of statin-induced myopathy is unknown but one possible mechanism suggested is due to mitochondrial dysfunction caused by reduced intramuscular coenzyme Q10 (9). Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble antioxidant found in all cell types throughout the body (10, 11).
[DOC File]International Journal of Biological Sciences
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Statin-induced myopathy has been associated with low CoEQ10 levels (Banach et al 2014), but research into the impact of CoEQ10 supplementation has failed to demonstrate improved tolerance. Therefore, this has not been approved by NICE as a co-prescribing strategy to address myopathy (NICE 2016).
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