Trityl deprotection mechanism

    • New Losartan-Antioxidant Hybrids for the Prevention of ...

      A relevant mechanism of cardiovascular disease progression in hypertensive patients may also be increased oxidative stress at the vascular level. Thus, treatments that interfere with this ...

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    • ((Title))

      A mechanism consistent with this observation was proposed involving formation of a thiourea-bound acylpyridinium•fluoride ion pair, followed by rate-determining desilylation of the silyl ketene acetal, and then enantio-determining acylation via a thiourea-bound acylpyridinium•enolate ion pair (Scheme 39).

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    • [DOC File]What is claimed is:

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      Hung and coworkers (Hung, D. Dimebon: A phase 3 investigational agent for Alzheimer's disease with a novel mitochondrial mechanism of action. Presented at the International Conference on Alzheimer's Disease, Chicago, IL, USA, July 2008; paper S4-04-05.) reported that dimebolin can protect cells from excitotoxic damage and improve neurite ...

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    • [DOCX File]Research Explorer | The University of Manchester

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      Figure 1. Schematic representation of the 18 uranium compounds investigated.The numbering scheme is used throughout the work, and superscripts indicate the sources of the experimental data. Each column features a different oxidation state of the uranium centre, including monomeric U(III), U(IV), U(V), U(VI) and dimeric U(V)–U(V).The circles indicate the system of colours that has been used ...

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    • [DOC File]((Title))

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      General mechanism The first synthesis of the β-lactam ring structure has been reported in 1907 by H. Staudinger.[7] The Staudinger synthesis is still one of the most popular methods in β-lactam chemistry and concerns a [2+2]-cyclocondensation between ketenes 5 , generated in situ by treatment of acid chlorides 4 with a mild base, and imines 6 ...

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    • [DOC File]In the bachelor thesis of Esther Schippers, research is ...

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      The synthesis of the (trityl protected) thiol scaffold was done in a comparable way as the alkene scaffold was synthesized. The retrosynthesis can be seen in scheme 18. Fmoc-piperazine (9) instead of Boc-piperazine (1) was used because of expected problems with the Boc-deprotection. The Boc-group is deprotected by acid, as is the trityl group.

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    • [DOC File]COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES

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      A deprotection of the Boc group provides compound 41. Other R2 groups may be installed by subjecting compounds 4 or 5 to other reactions, such as a Suzuki, Buchwald, or Ullmann coupling. It may be advantageous to separate reaction products from one another and/or from starting materials.

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    • Losartan-antioxidants Hybrids: Novel Molecules in the ...

      Oxidative stress is a well known mechanism that is responsible for the development of vascular damage.4 Different pathogenic stimuli involved in cardiovascular diseases, such as activated ...

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