Understanding clinical significance

    • [PDF File]P Values, Statistical Significance & Clinical Significance

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      definition for clinical significance will enhance its usefulness in research and practice. Methods Rodgers' evolutionary approach to concept analysis provides the framework for interpreting clinical significance in the context ofits uses, measurements, and defInitions in …

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    • CLINICAL, SIGNIFICANCE AS IT RELATED TO EVIDENCE BASED

      Nursing Research 101 Differentiating. statistical. significance. andclinical. significance. ByElizabethHeavey,PhD,RN,CNM . T. O IMPLEMENT. evidence-based practice, nurses must be able to comprehend and interpret research. That means you need to understand the distinction between statistical significance and clinical significance.

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    • [PDF File]Differentiating statistical significance and clinical ...

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      Repeated significance testing Aim: Ability to stop the trial earlier with statistically significant conclusions without increasing the type I and type II errors Want to choose boundaries at different time points for interim analyses while keeping the overall desired type I and type II errors. Pocock / O’Brien-Fleming boundaries H. 0 / H. 1

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    • [PDF File]Understanding Equivalence and Noninferiority Testing

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      Understanding the Clinical Significance of Non-Ventilator Hospital-Acquired Pneumonia (NV-HAP) Multistate Point-Prevalence Survey of Healthcare-Associated Infections1 n 183 Hospitals, 11,282 patients n Pneumonia #1 HAI (tied with SSI; 21.8%)

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    • Clinical significance - Wikipedia

      P Values, Statistical Significance & Clinical Significance When looking at the results of a research study, a practitioner has to answer two big questions: 1. Were the results due to chance? 2. Are the results big enough to matter to a patient? P values and Statistical Significance

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    • [PDF File]Understanding a - Amazon S3

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      Towards Understanding the Clinical Significance of QT Peak Prolongation- A Novel Marker of Myocardial Ischemia Independently Demonstrated in Two Prospective Studies Citation: Wong KYK, Velavan P, Wong SYS, Mcswiggan S, et al. (2015) Towards Understanding the Clinical Significance of QT Peak Prolongation- A

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    • [PDF File]UNDERSTANDING CLINICAL TRIAL STATISTICS

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      a previous clinical trial (Jacobson et al., 1989), discusses and provides tentative resolutions to some dilemmas inherent in the use of these procedures, and concludes by placing our method within a broader context. A Statistical Approach to Clinical Significance Explanation of …

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    • [PDF File]Understanding Corneal Topography

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      Clinical Significance: High Cancer Risk ... has made a lifetime commitment to understanding the nature of these variants. If new evidence about a variant is identified, that information will be made available to your healthcare provider who will then contact …

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    • [PDF File]Clinical Significance: A Statistical Approach to Defining ...

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      Understanding Equivalence and Noninferiority Testing Esteban Walker, PhD and Amy S. Nowacki, PhD Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA. Increasingly, the goal of many studies is to determine if new therapies have equivalent or noninferior efficacies to the ones currently in use. These studies are called

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    • [PDF File]Understanding the Clinical Significance of Non-Ventilator ...

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      Understanding Corneal Topography By Dianne Anderson ... clinical significance of corneal pathology in one eye as compared to the other. The Overview display can show four different views, in any combination, of the same exam for the selected patient. This display is a helpful

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