Vanco auc calculation
[PDF File]Vancomycin Pharmacokinetics, Dosing & Therapeutic Drug ...
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• AUC/MIC is the most useful PK/PD parameter to predict efficacy. Trough serum vancomycin concentrations considered most practical method for monitoring • Drawn at steady state, just before 4. th. dose. Trough concentration of 15-20 mg/L increases probability of obtaining optimal drug exposure • Trough of 15 mg/L easiest way to ensure ...
[PDF File]Things you will need for these cases: )*
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o AUC is calculated on the basis of paired peak and trough levels o Trough is… well, a trough ... Please also note that this rule applies for calculation of creatinine clearance ONLY. Anywhere else where weight is needed within the vancomycin protocol, just use the total body weight. Also, if you’re using Epic or an online calculator for ...
[PDF File]Vancomycin Dosing Guidelines - FormWeb
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concentration-time-curve (AUC) of 400-650 mg*hr/L while maintaining trough concentrations ≥10 mg/L. Palmetto Health Vancomycin Dosing Guidelines Prepared by PHASST (December 2017) Page 2 of 8 ... Allows calculation of patient-specific PK parameters rather than population estimates, including: 1. Patient-specific AUC 2. Patient-specific ...
[PDF File]INTRAVENOUS VANCOMYCIN DOSING AND MONITORING GUIDELINES
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ADULT INTRAVENOUS VANCOMYCIN DOSING AND MONITORING GUIDELINES DOSE: Adult dose: (based on actual body weight (ABW))*,^: 12.5 to 15 mg/kg (round off to nearest 250 mg increment, to max dose of 1500mg; see dosing table) * If ABW is > 30% ideal body weight (IBW), then use adjusted body weight = IBW + 0.4(Total body weight - IBW) IBW Males = 50 kg + 2.3 kg for each inch > 60 inches IBW Females ...
[PDF File]SHC Vancomycin Dosing Guide
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AUC 400 – 600 mg*h/L Trough ~15 (10-20) mg/L . Random 17-25 mg/L : Meningitis/ventriculitis (empiric or definitive) Trough-based protocol Trough 15-20 mg/L • In general, goal AUC/MIC ≥ 400 for S.aureus • Monitor closely with trough > 15 or AUC > 650: increased risk of nephrotoxicity
[PDF File]Curve Your Enthusiasm: Using AUC:MIC pharmacokinetics to ...
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Trough Correlation with AUC:MIC: •AAC 2014;58(1):309-316. PK Data from 47 patients across 3 studies (Total of 569 vancomycin levels) Methods: AUC with trough (AUC T) and AUC with peak-trough (AUC PT) vs. AUC with full data set (AUC F). Results: AUC T and AUC PT underestimated vs. AUC F. AUC T = 11-33% (p < 0.0001) / AUC PT
[PDF File]VANCOMYCIN NOMOGRAM FOR ADULT PATIENTS: GOAL AUC24 400-600
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calculate AUC, and adjust dose to achieve goal AUC of 400-600 •S Avoid obtaining vanco level during infusion or within 1 hour after completion of infusion • eptic shock or ECCMO ... • Monitor 2 vancomycin levels to facilitate AUC calculation, when possible • In patients receiving one-time doses (i.e., dosing by level), monitor random ...
[PDF File]AUC-Based Vancomycin Monitoring
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•AUC 24 calculated using the trapezoidal rule via an Excel®-based calculator •AUC 24 and trough values reviewed by a pharmacist • Assess the need for intervention •Patients also reviewed for vancomycin-related nephrotoxicity defined as: • Creatinine clearance less than 30 mL/min using Cockroft-Gault
[PDF File]Guidelines for Monitoring of Vancomycin Serum ...
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Calculation of the AUC/MIC is cumbersome since it involves serial vancomycin concentrations; therefore, trough concentrations are recommended as a surrogate marker.13 Trough concentrations are drawn within 30 minutes of the next dose and should be maintained above 10 mcg/mL for uncomplicated
[PDF File]Vancomycin AUC Dosing Fundamentals Introduction Summary ...
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Data Required to Determine AUC 24 • Vancomycin dose (mg) • Dosing interval (Tau, in hours) • Duration of Vancomycin infusion (Tinf, in hours) • Measured Vancomycin peak concentration (µg/mL) • Time from start of Vancomycin infusion to measurement of peak concentration (T1, in hours) • Measured Vancomycin trough concentration (µg/mL) • Time from start of Vancomycin infusion to ...
[PDF File]Vancomycin Online AUC Calculator User Guide
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- After filling the patient data and calculating AUC (as shown in picture above), use simple proportional method to make dose adjustments (i.e. if calculated AUC was 900 with 3g/day, a dose of 1.5g/d approximately correlates to an AUC of 450). - Do not use the calculator for: o Initial dosing recommendation
Basic & Applied Pharmacokinetics Self Assessment - Sample ...
A population pharmacokinetic analysis of vanco-mycin concentration-time data obtained from 374 infants with a median postnatal age of 70 days and ... Determine the AUC 24 /MIC on the chosen dose to determine if the dosing is adequate from this perspective. 1.13. Vancomycin3 5. A patient is receiving vancomycin 1.5 g every
[PDF File]AUC calculations and procedure Job-aide
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AUC Verbiage (.dotphrase): Vancomycin dosing may be optimized by AUC monitoring due to **** Assessment: 1. We used two post-distribution levels of *** μg/mL (date and time) and *** μg/mL (date at time) to calculate a vancomycin AUC. 2. Based on the current dosing regimen, we calculated an AUC of *** μg/mL x hr (target AUC is 400-600
[PDF File]1,2,3 for AUC Implementing the 2020 Vancomycin Dosing ...
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AUC/MIC 400-600 • AUC/MIC < 400 – encourages emergence of resistance • Assume MIC of 1 • Vancomycin-associated AKI – • Increased with AUC > 650 • Vancomycin monitoring • Patients at high risk for nephrotoxicity • Patients with unstable renal function • Patients receiving prolonged courses of therapy ( > 3-5 days)
Therapeutic monitoring of vancomycin for serious ...
the daily AUC values with trough-only PK sampling. However, the accuracy of AUC estimation is higher with peak and trough measurements compared to trough-only PK sampling.24 Using this validated Bayesian method to es-timate the daily AUC in a single-center, retrospective study of patients with MRSA bloodstream infections, Lodise
[PDF File]Vancomycin Dosing and Monitoring for Pediatric Patients
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also allows for AUC/MIC ratio >400. Clinical pharmacists will assess levels and make recommendations to the medical team for each level drawn. The maximum recommended dose for adult or pediatric patients is 100mg/kg/day or 6 grams/day. Patients should have vancomycin troughs and serum creatinine drawn on a weekly basis while on therapy ...
[PDF File]Useful Pharmacokinetic Equations - University of Florida
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AUC a b // Vd Vd Vcarea ss Creatinine Clearance CL male age weight creat Cp creat () 140 72 CL female age weight creat Cp creat () 140 85 With weight in kg, age in years, creatinine plasma conc. in mg/dl and CLcreat in ml/min
[PDF File]INTRAVENOUS VANCOMYCIN DOSING/MONITORING IN ADULTS OBJECTIVE
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6. AUC= Dose (mg; in 24H period)/CL a. Ex. 1000mg q12H = 2000mg in 24H period 7. For dose adjustment, a simple proportional method can be used (i.e. if calculated AUC was 900 with 3000mg/day, a dose of 1500mg/day approximately correlates to an AUC of 450) Ongoing monitoring and follow-up levels: o Stable patients
Vancomycin Pharmacokinetics, Dosing & Therapeutic Drug ...
estimated AUC Australia: MRSA bacteremia • 10 out of these 117 patients had AKI • 8 of those 10 had a high AUC • A trough of 10-15 mg/L is appropriate for a majority of patients, but 15-20 can be safe when AUC is known 28 Chavada et al. Antimicrob Agents Chemother. 2017; 61(5)
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