Vasopressors mechanism of action
[DOCX File]Extract from the Clinical Evaluation Report for Ephedrine ...
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Mechanism of action Ephedrine stimulates both alpha and beta adrenergic receptors, and also releases noradrenaline from storage sites. The main effects of therapeutic doses of ephedrine are relaxation of bronchial smooth muscle, cardiac stimulation, and increased blood pressure (via an increase in cardiac output and peripheral vasoconstriction).
[DOC File]Hemodynamic Drips
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-mechanism ultimately leads to Ca++ release -> inotropy/chronotropy -> incr CO. β-agonists: -most powerful way to increase contractility-all arrhythmogenic-desensitization develops when used continuously. Dobutamine β1, β2 agonist-Advantage over dopa in heart failure – mild vasodilation (especially at lower doses)
Moderna COVID-19 Vaccine EUA Fact Sheet for Healthcare ...
In a developmental toxicity study, 0.2 mL of a vaccine formulation containing the same quantity of nucleoside-modifie d messenger ribonucleic acid (mRNA) (100 mcg) and other ingredients included in a single human dose of Moderna COVID-19 Vaccine was administered to female rats by the intramuscular route on four occasions: 28 and 14 days prior to mating, and on gestation days 1 and 13.
[DOCX File]AusPAR Attachment 1: Product Information for Morphine ...
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Attachment 1: Product information for AusPAR Kapanol Morphine sulphate pentahydrate MaynePharma International Pty Ltd PM-2017-01592-1-5 FINAL 21 March 2019. This is the Product Information that was approved with the submission described in this AusPAR.It may have been superseded.
[DOC File]Stony Brook School of Medicine - Homepage | Renaissance ...
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Identify the indications, contraindications, mechanism of action and side effects of the commonly used cardiovascular drugs (antiarrhythmic, chromotropes, inotropes, diuretics, vasodilator, vasopressors). K Procedures GOAL X: Technical and therapeutic procedures. Describe the following procedures, including how they work and when they should be ...
[DOCX File]Vasopressin (Argipressin)
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Mechanism of action/pharmacology. Endogenous vasopressin is a hormone secreted by the posterior pituitary gland that acts as a non-adrenergic vasopressor. Actions on vascular smooth muscle V 1 receptors cause peripheral vasoconstriction and increase systemic vascular …
[DOCX File]EM-SERC Sim Template - EM Sim Cases
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Denise is a 59-year-old female who presents with a 7-day history of urinary symptoms, fever, and started with left flank pain. She has a history of STEMI 5 years ago. She then becomes unstable requiring fluid resuscitation, vasopressors, and empiric antibiotic treatment.
[DOCX File]Noradrenaline (Norepinephrine)
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Mechanism of action/pharmacology. Noradrenaline is a vasoconstrictor that predominantly stimulates α 1. receptors to cause peripheral vasoconstriction and increase blood pressure. It also has some β 1. receptor agonist activity that results in a positive inotropic effect on the heart at higher doses.1,2Onset of action: 1–2 minutes.2
[DOC File]QMC Adult Critical Care Induction Manual for Junior ...
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VASOPRESSORS. NORADRENALINE P 20 mg in 250 ml of 5% Dextrose A 0 – 1 microgram/kg/min I SEPTIC SHOCK . DISTRUBUTIVE SHOCK M Potent α adrenergic receptor agonist, moderate β1 receptor action; ↑vasoconstriction, myocardial vessel dilatation, ↑SVR and ↑BP.
[DOC File]MVC-AACN Newsletter
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5) Apply vasopressors (for hypotension that does not respond to initial fluid resuscitation) to maintain a mean arterial pressure (MAP) ≥65 mm Hg 6) In the event of persistent hypotension after initial fluid administration (MAP < 65 mm Hg) or if initial lactate was ≥4 mmol/L, re-assess volume status and tissue perfusion and document ...
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