Viral infection of the lung
[PDF File] Hepatitis C Virus and the Lung - CHEST
http://5y1.org/file/21227/hepatitis-c-virus-and-the-lung-chest.pdf
In this article, we discuss the emerging clinical data that support a role for HCV infection in lung disease, describe the multiple pulmonary manifestations of this viral infection, and outline the therapies available for specific pulmonary complications of …
[PDF File] Thoracic adipose tissue contributes to severe virus infection …
http://5y1.org/file/21227/thoracic-adipose-tissue-contributes-to-severe-virus-infection.pdf
The indirect impact of the secretory products of adipocytes during infection was analysed in a co-culture system with lung broblasts. Moreover, lung and adipose tissue was harvested from deceased ...
[PDF File] Type I and III interferons disrupt lung epithelial repair during ...
http://5y1.org/file/21227/type-i-and-iii-interferons-disrupt-lung-epithelial-repair-during.pdf
Thus, excessive or prolonged IFN production aggravates viral infection by impairing lung epithelial regeneration. Timing and duration are therefore critical parameters of endogenous IFN action and should be considered carefully for IFN therapeutic strategies against viral infections such as influenza and coronavirus disease 2019 (COVID-19).
[PDF File] Viral Infection, Pulmonary Fibrosis, and Long COVID
http://5y1.org/file/21227/viral-infection-pulmonary-fibrosis-and-long-covid.pdf
Viral Infection, Pulmonary Fibrosis, and Long COVID. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected hundreds of millions of people worldwide, resulting in long-term complications for many. The multiorgan syndrome known as “long COVID has emerged as an important socioeconomic issue, ” and long-term pulmonary ...
[PDF File] Epithelial plasticity and innate immune activation promote …
http://5y1.org/file/21227/epithelial-plasticity-and-innate-immune-activation-promote.pdf
Viral infection and chronic lung disease share similar pathological features of stem cell loss in alveoli, basal cell (BC) hyperplasia in small airways, and innate immune activation, that ...
[PDF File] Viral infection engenders bona fide and bystander subsets of …
http://5y1.org/file/21227/viral-infection-engenders-bona-fide-and-bystander-subsets-of.pdf
We show that two main subsets of MBCs permanently colonize the lung peribronchial niche upon respira-tory viral infection. These subsets arose from different progeni-tors that underwent class switching, somatic hypermutation (SHM) in GCs, and subsequently acquired divergent transcrip-tional programs and chemokine and Fc receptor patterns.
[PDF File] Interstitial macrophages are a focus of viral takeover and …
http://5y1.org/file/21227/interstitial-macrophages-are-a-focus-of-viral-takeover-and.pdf
These results identify activated IMs as a prominent site of viral takeover, the focus of inflammation and fibrosis, and suggest targeting CD209 to prevent early pathology in COVID-19 pneumonia. This approach can be generalized to any human lung infection and to evaluate therapeutics.
[PDF File] Supersulphides provide airway protection in viral and chronic …
http://5y1.org/file/21227/supersulphides-provide-airway-protection-in-viral-and-chronic.pdf
The viral fl infection affected Cars2+/− mice more extensively than did WT mice in terms of lung tissue damage and lethality, as well as in ammatory fl changes in the infected lungs, as assessed ...
[PDF File] Virus infection induced pulmonary fibrosis - Springer
http://5y1.org/file/21227/virus-infection-induced-pulmonary-fibrosis-springer.pdf
Wound healing response is activated at this time, however, the virus induces persistent lung damage and/or abnormal wound-healing, leading to development of pulmonary fibrosis. 2 Viral infection causes immune-mediated injury. After injury, the lung is in a state of inflamma-tory infiltration and the virus infection activates the immune system.
[PDF File] Interleukin-38 ameliorates poly(I:C) induced lung inflammation …
http://5y1.org/file/21227/interleukin-38-ameliorates-poly-i-c-induced-lung-inflammation.pdf
The primary cells being infected during viral infection are respiratory epithelial cells, and the interaction of respiratory epithelial cells with macrophages of barrier organs constitute the rst ...
[PDF File] The lungâ gut axis during viral respiratory infections: the …
http://5y1.org/file/21227/the-lungâ-gut-axis-during-viral-respiratory-infections-the.pdf
We summarize the impact of viral respiratory infections on the gut microbiota and discuss the potential mechanisms leading to alterations of gut microbiotas composition and functions.
[PDF File] Sleep and circadian rhythm disruption alters the lung …
http://5y1.org/file/21227/sleep-and-circadian-rhythm-disruption-alters-the-lung.pdf
Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. How-ever, the mechanism(s) underpinning higher rates of respiratory viral infection following SCRD remain poorly characterized. To address this, we investigated the effects of acute sleep deprivation on …
[PDF File] Coinfections in the lung: How viral infection creates a …
http://5y1.org/file/21227/coinfections-in-the-lung-how-viral-infection-creates-a.pdf
Many of the physiologic and immunologic outcomes in the lung resulting from respiratory viral infection, especially with influenza viruses, are well established as to their role in second-ary bacterial infection susceptibility and beginning to be elucidated for secondary fungal infec-tions.
[PDF File] Type I and III interferons disrupt lung epithelial repair during ...
http://5y1.org/file/21227/type-i-and-iii-interferons-disrupt-lung-epithelial-repair-during.pdf
During infection with respiratory viruses, disease severity is linked to lung epithelial destruction, due to both cytopathic viral effects and immune-mediated damage. Epithelial loss contributes to acute respiratory distress syndrome, pneumo-nia, and increased susceptibility to bacterial superinfections.
[PDF File] Good and bad outcomes of respiratory viral infectionsâ …
http://5y1.org/file/21227/good-and-bad-outcomes-of-respiratory-viral-infectionsâ.pdf
Good and bad outcomes of respiratory viral infections— influenza A virus trains sustained antitumor immunity of macrophages in the lung Sabine Stegemann-Koniszewski1,4, Sarah Frentzel2,3,4 and ...
[PDF File] Mechanical control of innate immune responses against viral …
http://5y1.org/file/21227/mechanical-control-of-innate-immune-responses-against-viral.pdf
However, it is fi unknown if this model can accurately replicate human lung responses to inuenza viral infection and explore the role of fl breathing motions during disease progression.
[PDF File] Epidemic and pandemic viral infections: impact on …
http://5y1.org/file/21227/epidemic-and-pandemic-viral-infections-impact-on.pdf
The epidemiology and immunology of these viral infections and their interactions with TB are discussed with implications for diagnosis, treatment and prevention of airborne infections (infection control, viral containment and workplace safety). This consensus document represents a rapid and comprehensive summary on what is known on the topic.
[PDF File] The Role of Infection in Interstitial Lung Diseases - CHEST
http://5y1.org/file/21227/the-role-of-infection-in-interstitial-lung-diseases-chest.pdf
Interstitial lung disease (ILD) comprises an array of heterogeneous parenchymal lung diseases that are associated with a spectrum of pathologic, radiologic, and clinical manifestations. There are ILDs with known causes and those that are idiopathic, making treatment strategies chal-lenging. Prognosis can vary according to the type of ILD, but …
[PDF File] Invasive fungal infections after respiratory viral infections in …
http://5y1.org/file/21227/invasive-fungal-infections-after-respiratory-viral-infections-in.pdf
Lung transplant recipients (LTRs) have improved short-term TagedP lung allograft survival within the first year; however, their long-term survivals have been affected by chronic lung allograft dysfunction (CLAD).1,2 Respiratory viral infections (RVIs) and fungal infections are known to LTRs.3-8 increase risk of CLAD and mortality in Fungal ...
[PDF File] What makes people with diabetes more susceptible to serious …
http://5y1.org/file/21227/what-makes-people-with-diabetes-more-susceptible-to-serious.pdf
Dendritic cell recovery, in turn, reversed the marked diabetes-induced susceptibility to viral infection of the lung and its devastating ramifications.
[PDF File] Exposure to lung-migrating helminth protects against murine …
http://5y1.org/file/21227/exposure-to-lung-migrating-helminth-protects-against-murine.pdf
Here, we show that lung remodeling from a prior infection with a lung-migrating helminth, Nippostrongylus brasiliensis, enhances viral clearance and survival of human-ACE2 transgenic mice challenged with SARS-CoV-2 (SCV2).
[PDF File] Diabetes and pulmonary infection: how hyperglycaemia …
http://5y1.org/file/21227/diabetes-and-pulmonary-infection-how-hyperglycaemia.pdf
The study clearly demonstrates that high glucose levels are a major determinant of lung DC function and provides a novel concept of how chronic hyperglycaemia can impair host defence against viral ...
[PDF File] Memory CD4 T cell-derived IL-2 synergizes with viral infection …
http://5y1.org/file/21227/memory-cd4-t-cell-derived-il-2-synergizes-with-viral-infection.pdf
These results suggest that IL-2 production is not necessarily an indicator of protective CD4 T cells, and that the lung environment is particularly sensitive to IL-2-induced inflammation during viral infection.
[PDF File] Type I and III interferons disrupt lung epithelial repair during ...
http://5y1.org/file/21227/type-i-and-iii-interferons-disrupt-lung-epithelial-repair-during.pdf
Thus, excessive or prolonged IFN production aggravates viral infection by impairing lung epithelial regeneration. Timing and duration are therefore critical parameters of endogenous IFN action and should be considered carefully for IFN therapeutic strategies against viral infections such as influenza and coronavirus disease 2019 (COVID-19).
[PDF File] Recovering from a Serious Lung Infection
http://5y1.org/file/21227/recovering-from-a-serious-lung-infection.pdf
Respiratory infections, like COVID-19 or influenza, cause inflammation of your airways and your lungs. Infections may be mild or severe. For severe lung infections, the recovery time can be extensive. It is important to know what to watch for, when to seek additional help and how to maintain optimal lung health as your body recovers.
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