What is clinical significance definition

    • [PDF File]PDF Clinical Significance 1 Running Head: CLINICAL ... - ERIC

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      Clinical significance is an important concept in research, particularly in education and the social sciences. The present article first compares clinical significance to other measures of "significance" in statistics. The major methods used to determine clinical significance are explained and the strengths and weaknesses of clinical ...

    • [PDF File]PDF Clinical Significance: A Statistical Approach to Denning ...

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      to criteria based on statistical significance, judgments regard-ing clinical significance are based on external standards pro-vided by interested parties in the community. Consumers, clini-cians, and researchers all expect psychotherapy to accomplish particular goals, and it is the extent to which psychotherapy

    • Glossary of Terms on Clinical Trials for Patient Engagement ...

      GLOSSARY OF TERMS ON CLINICAL TRIALS FOR PATIENT ENGAGEMENT ADVISORY COMMITTEE MEETING 1 TERM DEFINITION Assent A child's affirmative agreement to participate in a clinical investigation.

    • Gastrointestinal bacterial overgrowth: pathogenesis and ...

      be used as the definition of SIBO (Box 1). What is unique about SIBO is that there are exces - sive numbers of aerobic and anaerobic bacteria Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance Amit H. Sachdev and Mark Pimentel Abstract: Small intestinal bacterial overgrowth (SIBO) is defined as the presence of an

    • [PDF File]PDF P Values, Statistical Significance & Clinical Significance

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      P Values, Statistical Significance & Clinical Significance When looking at the results of a research study, a practitioner has to answer two big questions: 1. Were the results due to chance? 2. Are the results big enough to matter to a patient? P values and Statistical Significance

    • [PDF File]PDF Methods for Defining and Determining the Clinical ...

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      However the concept is defined, there are a variety of ways to operationalize clinical significance in mathematical terms. It is possible to distinguish the conceptual definition from its mathematical interpretation. Each has its own areas of controversy, and some of the mathematical debate is quite esoteric. Moreover, the

    • [PDF File]PDF Statistical significance and statistical power in hypothesis ...

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      Statistical Significance and Statistical Power in Hypothesis Testing Richard L. Lieber Division of Orthopaedics and Rehabilitation, Veterans Administration Medical Center and University of California, Sun Diego, CA, U.S.A. Summary: Experimental design requires estimation of the sample size required to produce a meaningful conclusion.

    • Clinical significance of free-floating venous thrombi

      Clinical significance venous thrombi of free-floating E. Douglas Baldridge, MD, 1 Michael A. Martin, BS, 2 and Richard E. Welling, MD, 2 Cincinnati, Ohio To evaluate the fate of free-floating venous thrombi, venous duplex scans of 5238 con-

    • [PDF File]PDF The Clinical Significance of Relative Bradycardia

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      and lack of a consistent definition used. The fact that this sign is not consistently identified in case series suggests that relative bradycardia is caused by mechanisms presumably involving or influenced by pathogen and host factors. Conclusions: Relative bradycardia is a sensitive but nonspecific clinical sign that may be an

    • [PDF File]PDF Overall Impact versus Significance

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      Overall Impact versus Significance . The distinction between Significance and Overall Impact has generated some confusion since the implementation of . NOT-OD-09-025, "Enhancing Peer Review: The NIH Announces Enhanced Review Criteria for Evaluation of Research Applications Received for Potential FY 2010 Funding".

    • [PDF File]PDF When Is a Medication Error Clinically Significant?

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      WHEN IS A MEDICATION ERROR CLINICALLY SIGNIFICANT? An important aspect of the long term care survey process consists of evaluating the safety and effectiveness of the facility's system for preparing and administering medications to its residents. This is accomplished by conducting the medication pass observation, otherwise known as "Task 5 ...

    • Microalbuminuria: Definition, Detection, and Clinical ...

      Microalbuminuria: Definition, Detection, and Clinical Significance Robert D. Toto, MD From the University of Texas Southwestern Medical Center-Dallas, Dallas, TX Address for correspondence: Robert D. Toto, MD, Professor of Medicine, University of Texas Southwestern Medical Center-Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-8856

    • PDF Clinical, Significance As It Related to Evidence Based

      definition for clinical significance will enhance its usefulness in research and practice. Methods Rodgers' evolutionary approach to concept analysis provides the framework for interpreting clinical significance in the context ofits uses, measurements, and defInitions in the nursing literature.

    • [PDF File]PDF Pain symptoms in depression: definition and clinical significance

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      ings on the definition and clinical significance of painful symptoms in patients with depression. About 50% of depressed patients report pain, and many types of pain occur more frequently in people with depression than in those without. There is some evidence that pain in depressed patients is associated with a poor response to treatment.

    • The Usage and Meaning of 'Clinical Significance' in Drug ...

      phrase "clinical significance" several times throughout its opinion, nowhere does it provide any definition or explication. The best indication of the While these standards can be tied only to the word "significant," rather than to the entire phrase "clinical significance," the addition of "clinical" often appears in the Black Lung case

    • [PDF File]PDF The "art" Clinical Validation - ACDIS

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      the "art" clinical validation laurie l. prescott rn, msn, ccds, cdip ahima approved icd-10 cm/pcs trainer cdi education specialist -hcpro, a division of blr

    • [PDF File]PDF Differentiating statistical significance and clinical ...

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      Nursing Research 101 Differentiating. statistical. significance. andclinical. significance. ByElizabethHeavey,PhD,RN,CNM . T. O IMPLEMENT. evidence-based practice, nurses must be able to comprehend and interpret research. That means you need to understand the distinction between statistical significance and clinical significance.

    • PDF The Meanings and Measurement of Clinical Significance

      assessment of clinical significance to the goals of therapy, and the construct(s) that clinical significance reflects. Recommended directions for research are also highlighted and include developing a typology of therapy goals, evaluating cutoff scores and thresholds for clinical significance, and attending to social as well

    • PDF Statistical versus Practical Significance - The Atrium

      2 If we chose α= 0.05, we are insisting that evidence against H 0 is so strong that it would happen no more than 5% of the time (1 time in 20) when H 0 is true. If we chose α= 0.01, we are demanding even stronger evidence

    • [PDF File]PDF Monoclonal Gammopathy of Clinical Significance (MGCS)

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      * Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or significant, Leung N, Bridoux F, et al. Blood 2012 * Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications, Fermand JP, Bridoux F, et al. Blood 2018 and made recommendations based on expert opinion

    • [PDF File]PDF Urinary Tract Infection - What is It? Definition of "UTI"

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      Clinical: bacteria causing dz, need treatment >10 5cfu/mL criterion for "significance" - Microbiological Designed for voided samples in asxpatients to distinguish vaginal and urethral contamination from bacteria truly from the bladder Not informative re. clinical significance of bacteria Unsuited for symptomatic or catheter-associated UTI

    • Clinical Significance of Hyperkeratosis and Parakeratosis in ...

      To ascertain the clinical significance of hyperkeratosis and par- akeratosis in otherwise negative Papanicolaou smears, we ret- rospectively reviewed 96 patients with these findings seen during a 32-month period. Evaluation included repeating the smear and performing colposcopy in all patients.

    • Fda Fact Sheet

      Level 3: Cancer Mutations with Potential Clinical Significance. Mutations not considered biomarkers in Level 1 or Level 2 can be described as cancer mutations with potential clinical significance.

    • Incidence and Clinical Significance

      mined the incidence and clinical significance of tracheobronchial lacerations after balloon dilation for treatment of benign tracheobronchial strictures. Methods: We evaluated 97 patients who had undergone balloon dilation in 124 sessions for the treatment of benign tracheobronchial strictures. The degree of airway laceration was evaluated

    • [PDF File]PDF Upper Airway Cough Syndrome - Definition, Pathogenesis And ...

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      Upper Airway Cough Syndrome - Definition, Pathogenesis and Clinical Significance. ABSTRACT. Chronic cough is a troublesome problem, which considerably reduces the quality of life of affected individuals. Standardized diagnostic protocols focus mainly to the three most frequent . reasons of chronic cough, so-called diagnostic triad.

    • [PDF File]PDF Vol. 5, No. 1, January 2009 "Can You Handle the Truth?"

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      Lab reports require review by a qualified investigator to determine clinical significance. If a clinically significant lab result is found, document an adverse event. Write the event description as specifically and informatively as possible, depending on the investigator's (tentative) diagnosis at the time.

    • [PDF File]PDF A Practical Introduction to Clinical Data Acquisition ...

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      A Practical Introduction to Clinical Data Acquisition Standards Harmonization (CDASH) Jennifer Price, Phoenix Data Systems, Inc, King of Prussia, PA ABSTRACT On October 1st, 2008, CDASH released the first 16 common CRF streams (or domains) for use by the Pharmaceutical Industry.

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