What is statistically significant evidence

    • [PDF File]Significant evidence at the highest level - Smith & Nephew

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      Significant evidence at the highest level The Cochrane Review of antiseptics and antibiotics for venous leg ulcers concluded:1 • In terms of topical preparations, there was evidence to support the use of Cadexomer Iodine. • For therapy under compression, there was statistically significant evidence in …

    • [PDF File]EVIDENCE-BASED DERMATOLOGY: STUDY Statistical …

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      EVIDENCE-BASED DERMATOLOGY: STUDY Statistical Significance and Clinical Relevance The Importance of Power in Clinical Trials in Dermatology ... may detect statistically significant differ-ences that are clinically irrelevant. We have arbitrarily selected from the

    • [PDF File]When is statistical significance not significant? - SciELO

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      When is statistical significance not significant? ... the p value is a continuous measure of evidence, but in practice it is typi-cally trichotomized approximately into highly significant, marginally significant, and not statistically significant at conventional levels, with cutoffs at …

    • Statistical versus Practical Significance - The Atrium

      meaningful evidence in research work. It is important to note that there is no sharp border between statistically significant and insignificant results. There is no practical distinction between the P-values 0.049 and 0.051. Therefore, it doesn't make sense to treat α= 0.05 as a universal rule for what is significant. Summary

    • [PDF File]P Values, Statistical Significance & Clinical Significance

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      P Values, Statistical Significance & Clinical Significance ... The results of a study can be statistically significant but still be too small to be of any practical value. This is of great importance to physicians when looking at research evidence.

    • [PDF File]Differentiating statistical significance and clinical ...

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      statistically significant difference is clinically significant. across multiple patient populations, the statistically significant result may be only minimally useful and thus isn’t clinically significant. If a statistically significant result isn’t clinically significant, it’s not clinical-ly helpful and shouldn’t be used to

    • CLINICAL, SIGNIFICANCE AS IT RELATED TO EVIDENCE BASED

      significance: while the P values ofa statistically significant fmding indicate the likelihood ofthe change being caused by chance, CS goes beyond statistical significance to identify whether the statistically significant change or difference was large enough to have implications for patient care (Sloan et. aI., 2002; Pittman & Rawls, 2008).

    • [PDF File]Redefine statistical significance .edu

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      claim statistically significant results with the P 10< 0.05 threshold . However, replication rates were very low5 for these studies, suggesting a potential for gains by adopting this new standard in these fields as well. Potential objections We now address the most compelling arguments against adopting this higher standard of evidence.

    • [PDF File]A simulation study of the strength of evidence in the ...

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      p>.05 are allowed among the set of trials that contains these two statistically significant trials. Combining evidence in such a fashion is statistically inappropriate and can lead to wildly dif-fering levels of strength of evidence. In this paper, we will present through simulation the extent to which strength of evidence

    • [PDF File]Statistical Significance 101

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      can lead to a “publication bias” or “file drawer problem” whereby results that are not statistically significant, but important because they are not significant, are not published and therefore often left out of systematic reviews or meta-analyses. How is statistical significance used in evidence-based medicine? 1.

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