Zosyn mssa bacteremia

    • [PDF File]Staphylococcus aureus Bloodstream Infection Treatment ...

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      Management of Staphylococcus aureus Bacteremia . 1. Recommended Therapy for S. aureus Bacteremia a. MSSA: Studies have shown that treatment with vancomycin is associated with increased mortality risk compared to beta-lactam therapy even when therapy was altered after culture results identified MSSA.

    • [PDF File]Bugs n drugs - Emory University

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      MSSA, S. pneumoniae, P. mirabilis, E. coli, K. pneumoniae Second Generation Cefuroxime (po, IV – Ceftin, Zinacef) Community acquired infections Gram positive (pneumococci and S. aureus); increased activity against H. flu, E. coli, Klebsiella and Proteus Cefoxitin (IV – Mefoxin) Increased anaerobic activity, including excellent B fragilis ...

    • [PDF File]ZOSYN (Piperacillin and Tazobactam for Injection, USP) Rx ...

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      Each ZOSYN 4.5 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 4 grams of piperacillin and tazobactam sodium equivalent to . 0.5. g of tazobactam. The product also contains 1 mg of EDTA per vial. ZOSYN (piperacillin and tazobactam for injection, USP) contains a total of 2.79 mEq (64 ...

    • [PDF File]IDSA Guidelines on the Treatment of MRSA Infections in ...

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      cated bacteremia), four to six weeks of therapy is recom-mended, depending on the extent of infection. Some experts recommend higher dosages of daptomycin (8 to 10 mg per kg intravenously once per ...

    • [PDF File]MSSA: oxacillin versus other beta- lactam choices

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      Clinical Isolates of MSSA: Frequency and Possible Cause of Cefazolin Treatment Failure Antimicrob Agents Chemother 2009; 53: 3437-41 Type of ß-lactamase (n=98) cefazolin MIC (µg/mL) std. inoculum A Bla producers (n=25) B Bla producers (n=15) C Bla producers (n=45) Bla-negative strains (n=13) 1.3 0.9 0.9 0.6 Std 5 inoculum= 5x10 CFU/mL

    • [PDF File]GUIDELINES FOR TREATMENT OF BONE AND JOINT INFECTIONS IN ...

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      • If known MSSA colonization or infection: Other risk for bacteremia e.g., central line, dialysis, sickle cell disease, urethral catheterization, UTI Bacterial Etiology: • S. aureus • + 30% Gram negative bacilli (consider if fresh water exposure, recent broad spectrum antibiotics in the prior 90 days, recent >2 days hospitalized in

    • [PDF File]Bloodstream Infections

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      Vancomycin is inferior to oxacillin or cefazolin for treatment of MSSA. Do not choose vancomycin solely due to convenience of dosing (such as in dialysis patients). All patients with S. aureus bacteremia should have an echocardiogram to rule out endocarditis. Clinical suspicion and physical exam findings do not correlate with

    • [PDF File]for drug selection and dosing questions. Table 1 ...

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      Imipenem ≤ 2 4 ≥ 8 Levofloxacin ≤ 2 4 ≥ 8 Meropenem ≤ 2 4 ≥ 8 Minocycline (Acinetobacter only) ≤ 4 8 ≥ 16 Piperacillin-tazobactam ≤ 16/4 32/4 – 64/4 ≥ 128/4

    • [PDF File]Prescribing antibiotics in the clinical setting

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      for MSSA •Superior anti-staphylococcal killing when compared to glycopeptides for MSSA •IDSA has dosing recommendations for HD Cons •Less rapidly cidal •Has been associated with poor patient outcomes – nephrotoxicity, persistent bacteremia, treatment failures •Frequent dosing administration •Warrants allergy assessment ...

    • [PDF File]Healthcare Superbugs: The Re-Emergence of Hospital Pathogens

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      39 episodes of S.aureus bacteremia were identified • 15 MSSA ... = Zosyn: Good News: Beta-lactamase inhibitors inhibit the beta lactamase thereby not allowing the molecule to hydrolyze the antibiotic. Most ESBLS remain susceptible to Beta- lactamase inhibitors :

    • [PDF File]Updates in Antibiotic Therapy for Common Illnesses

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      MRSA), especially effective against MSSA • Used primarily for skin and soft tissue infections and peri-operative prophylaxis • Cefazolin is a drug of choice for MSSA infections, including bacteremia and endocarditis

    • [PDF File]EMPIRIC ANTIBIOTIC GUIDELINES FOR SKIN AND SOFT TISSUE ...

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      (MSSA). Michigan Medicine S. aureus resistance rates are lowest for TMP-SMX2 (2%) and doxycycline (3%), compared to clindamycin (28% in 2018). Methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) exhibit similar rates of clindamycin resistance. If worsening or not improving after 48 hours of oral antibiotic therapy,

    • [PDF File]Table 3: Suggested Antibiotics, Doses and Duration for ...

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      Catheter-related bacteremia and Cellulitis MSSA Penicillin non-allergic Nafcillin or oxacillin 50mg/kg up to 2g q4h or Cloxacillin or flucloxacillin or dicloxacillin 25mg/kg up to 1g q6h Oral cloxacillin, flucloxacillin or dicloxacillin at same dose 2 weeks Minor penicillin allergy Cephalothin 50mg/kg up to 2g q6h or cefazolin 25mg/kg 1g q8h

    • [PDF File]Intravenous to Oral Conversion for Antimicrobials

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      o Bacteremia with staphylococcus aureus or Enterococcus species o Severe sepsis o CNS infection (e.g., meningitis, encephalitis) o Endophthalmitis o Endocarditis o Osteomyelitis/discitis o Vertebral or deep abscesses o Bone and joint infections o Septic arthritis . ...

    • [PDF File]Infections in Mechanical Support Devices

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      •MSSA- lifelong if tolerated –No risk of resistance with beta lactams –Oral- Keflex- exit site infections –IV- Ancef then Ceftriaxone- bacteremia –Highly aggressive organism •MRSA –Any concern for worsening local infection, bacteremia –Oral- Clindamycin, Bactrim –IV- vancomycin, daptomycin, ceftaroline, telavancin

    • [PDF File]Pulmonary Infections

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      for MRSA bacteremia, even if associated with a pulmonary source, is not recommended. In the absence of necrotizing pneumonia with cavitation, empiric coverage for CA-MRSA can be deferred until sputum and blood culture results return given their high diagnostic yield for CA-MRSA. Pathogen-specific treatment and duration

    • [PDF File]Piperacillin/tazobactam (Zosyn®)

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      Its Gram-positive activity is limited to Streptococcus spp., E. faecalis, and MSSA. It does NOT have activity against MRSA or Stenotrophomonas spp. It is also active against wide range of anaerobes.

    • [PDF File]Skin and Soft Tissue Infections: Treatment Guidance

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      (normally MSSA) Mild • Cephalexin 500mg PO q6h . OR • Dicloxacillin 500mg PO q6h. Severe Penicillin Allergy: Clindamycin 300 mg PO q8h . Moderate-severe • Cefazolin 2g IV q8h . OR • Oxacillin 2g IV q6h. Severe Penicillin Allergy: Clindamycin 600 mg IV q8h. Severe systemic illness or no response/worsening at 48 hours

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