Clinical significance and statistical significance
ACR 20: Clinical or statistical significance?
The issue of statistical versus clinical significance in clinical trial results is relevant to clinical care. Com-pared with the ACR 50 or ACR 70, the ACR 20 is a superior statistical discriminant between drug and pla-cebo. However, many rheumatologists might not regard a 20% reduction of, say, 15 tender or swollen joints to 12
[PDF File]The Meanings and Measurement of Clinical Significance
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The Meanings and Measurement of Clinical Significance Alan E. Kazdin Department of Psychology Yale University ABSTRACT The previous articles in this special section make the case for the importance of evaluating the clinical significance of therapeutic change, present key measures and innovative ways in …
Statistical Significance Versus Clinical Importance
2. Statistical significance does not equal clinical importance. It only tells us that the observed differences in the outcome are unlikely to be due to "chance alone." This may be a useful first step in evaluating the importance of the observed differences, but it is important to examine the clinical importance of the observed differences.
[PDF File]Defining clinical vs. statistical significance
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Defining clinical vs. statistical significance 25 June 2015, by Sean Sinden The problem with P values The practice of null hypothesis testing has
[PDF File]White Paper - Statistical Significance versus Clinical ...
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WHITE PAPER Page - 3 Statistical Significance versus Clinical Significance in Clinical Trials even though there is a real difference (i.e., the null hypothesis is …
[PDF File]Statistical Significance - Statistics Improves Health Care
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The American Statistical Association is the foremost professional society of statisticians, representing 18,000 scientists in industry, government, and academia: www. amstat.org. This Statistical Significance was produced under the supervision of the ASA Section on Health Policy Statistics, with input from the ASA Section on Statistics in ...
[PDF File]Running head: CLINICAL SIGNIFICANCE DECISION
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The problem for the researcher is that clinical significance is subjective, and science worships objectivity. Classical statistical significance testing has survived a host of challenges (Schmidt & Hunter, 1997), primarily because applying the techniques is very much like following a recipe, with little judgment involved once the dish has been
DSM-IV Diagnostic Criterion for Clinical Significance ...
the clinical significance criterion for major depressive disorder, but the broader use of the clinical significance criterion throughout the manual was not discussed. A paragraph explaining the reasons for introducing the clinical significance criterion into DSM-IV appears in the section Use of the Manual: Criteria for Clinical Significance
[PDF File]On reporting and interpreting statistical significance and ...
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more helpful than the abandonment of statistical significance testing, which is a tool that can be used well, or misused and even abused. 2. Similarly, in this perspective, we argue that abandoning statistical significance because scientists misuse p values does not address the underlying problems of statistical …
CLINICAL SIGNIFICANCE OF ANTINUCLEAR ANTIBODIES
1612 ARTHRITIS & RHEUMATISM Vol. 40, No. 9, September 1997, pp 1612-1618 0 1997, American College of Rheumatology CLINICAL SIGNIFICANCE OF ANTINUCLEAR ANTIBODIES Comparison of Detection with Immunofluorescence and Enzyme-linked Immunosorbent WOODRUFF EMLEN and LAURIE O’NEILL Objective. To compare the measurement of anti-
[PDF File]The Role of Clinical Significance in Outcome Evaluation
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Statistical Significance Findings Pre-post Functioning Mean Comparison Significant Change (t = 3.388, p = .001) Effect Size Calculation d = .33; Small to medium effect Statistical Significance Clinical Significance
[PDF File]When is statistical significance not significant?
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The statistical difficulties arise more generally with findings that are sug-gestive but not statistically significant. (A. Gelman and D. Weakliem) The research methodology literature in recent years has included a full frontal assault on statistical significance testing. (J. E. McLean and J. M. Ernest)
STATISTICAL VS. CLINICAL SIGNIFICANCE IN RESEARCH ON …
Statistical significance may be an inadequate criterion for determining the clinical utility of a therapeutic intervention evaluated within the context of the treatment vs. no treatment paradigm, but it can be of considerable value in helping one choose the best of several interventions that are
The Usage and Meaning of 'Clinical Significance' in Drug ...
"CLINICAL SIGNIFICANCE" IN DRUG-RELATED LITIGATION 555 definitions, either alone or in concert, for a given context, the potential problems are minimized, if not obviated entirely.' Such definitions may come from statutes or from precedents in case law.' The definitions may be, and 4.
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