Hypertrophic cardiomyopathy apical var
[PDF File]RESEARCH Open Access The KCNE genes in hypertrophic …
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RESEARCH Open Access The KCNE genes in hypertrophic cardiomyopathy: a candidate gene study Paula L Hedley1,2, Ole Haundrup3, Paal S Andersen4, Frederik H Aidt1, Morten Jensen5, Johanna C Moolman-Smook2, Henning Bundgaard5 and Michael Christiansen1* Abstract Background: The gene family KCNE1-5, which encode modulating b-subunits of several repolarising K+-ion channels, has been associated …
[PDF File]Isogenic Pairs of hiPSC-CMs with Hypertrophic …
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Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC- Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits James G.W. Smith, 1,7,10, * Thomas Owen, 2,10 Jamie R. Bhagwan, 1 Diogo Mosqueira, 1 Elizabeth Scott, 1
[PDF File]Hypertrophic Cardiomyopathy: A Systematic Review
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apex (asterisk), consistent with the designation of apical hypertrophic cardiomyopathy (HCM); E, relatively mild hypertrophy in a concentric (symmetric) pattern with each segment of ventricular septum and LV free HYPERTROPHIC CARDIOMYOPATHY
[PDF File]Resolution of left ventricular thrombus with apixaban in a patient …
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ondary to hypertrophic cardiomyopathy and AF is described in the present report. Indications for oral anticoagulation were AF and LV thrombus. Thrombus was dissolved after 1 month of apixaban treatment. To the best of our knowl-edge, this is the first report that describes the resolution of LV thrombus with apixaban treatment in a patient with hy-
1.3 Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HC) is an inherited disorder of myocardium caused by mutations in sarcometric contractile proteins.The distribution and magnitude of left ventricular hypertrophy are not uniform in patients with HC. In the late 1970s, the pathognomonic septal configuration is
Gene Mutations in Apical Hypertrophic Cardiomyopathy
Key Words: hypertrophy cardiomyopathy genetics remodeling S ince the first application of echocardiography to the diagnosis of hypertrophic cardiomyopathy, cardiologists have recognized that the distribution of ventricular and septal wall thickening in hypertrophic cardiomyopathy (HCM) var-ies widely. Ventricular hypertrophy in HCM can be focal or
[PDF File]Hypertrophic Cardiomyopathy in Northern Sweden
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Hypertrophic cardiomyopathy (HCM) is a heterogeneous, often familial disease, characterized by cardiac hypertrophy, predominantly affecting the interventricular septum. To date, no study has systematically analysed the genetic and phenotypic aspects of the disease in a Swedish population. The aim of this thesis was to identify the genotypes causing HCM in northern Sweden, to characterize the disease …
Hypertrophic Cardiomyopathy: The Great Masquerader
Hypertrophic Cardiomyopathy: The Great Masquerader Clinical Conference from the Cardiology Branch of the National Heart, Lung, and Blood Institute, Bethesda, Md Moderator: BarryI. Maron, M.D. Senior Investigator Participants: John S. Gottdiener, M.D. Staff Associate Dr. Barry]. Maron: Hypertrophic cardiomyopathy is a genetically transmitted disease of cardiac muscle that has often been a …
Phenotypes of hypertrophic cardiomyopathy. An illustrative review …
Hypertrophic cardiomyopathy (HCM) is a genetic cardio-vascular disease, defined by an increase in the left ven-tricular wall thickness (end-diastolic left ventricular wall thickness≥15 mm or the equivalent relative to the body surface area in children) that is not solely explained by abnormal loading conditions. Lesser degrees of wall
Surgical Treatment of Hypertrophic Cardiomyopathy
Surgical Treatment of Hypertrophic Cardiomyopathy Sameh M. Said, MD, and Hartzell V. Schaff, MD Hypertrophic cardiomyopathy (HCM) is a unique primary myocardial disease characterized by unexplained left ventricular hypertrophy in absence of another etiology. One of the key features is
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