Natural phosphodiesterase 5 inhibitors
[DOCX File]Last Updated August 20th, 2001 - University of Iowa ...
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33.Title: Inhibitors of Phosphodiesterase Type 5A for Treating or Preventing Muscle Disease or the Symptoms Thereof in a Patient. Inventors: Kevin P. Campbell, Yvonne Kobayashi, and Robert Crawford Patent No: 20140005202Application Issue: January 2, 2014
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Our PDE1 inhibitors ameliorate both of these effects in animal models. We intend to pursue the development of our phosphodiesterase, or PDE, program, for the treatment of several CNS and non-CNS conditions with a focus on diseases where excessive PDE1 activity has been demonstrated and increased inflammation is an important contributor to ...
Investor Relations | PhaseBio Pharmaceuticals, Inc.
biological processes. Nitric oxide causes blood vessels to relax and widen, resulting in an increase in blood flow. Oral drugs such as sildenafil, marketed by Pfizer as Revatio, and tadalafil, marketed by United Therapeutics as Adcirca, are phosphodiesterase type 5 inhibitors that work by enhancing the activity of naturally occurring nitric oxide.
[DOC File]The Variability of Women’s Sexuality; a Theoretical Approach
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Since the turn of the century, following the impact of Viagra and other phosphodiesterase-5 inhibitors on male erectile response, attempts have been made to find a “Viagra for women.” The limited success so far may in part result from the lack of consideration of the marked variability in the non-problematic sexuality of women.
[DOCX File]Viktor's Notes – Sexual Disorders
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- nervous system, from peripheral receptors to cerebral cortex, is sensitized and remodeled for unknown reasons - trivial stimulus (e.g. touch with cotton swab) is perceived as significant pain (allodynia); pain stops when penile movement stops and resumes when it starts again (vs. vaginismus); may leave postcoital vulvar burning and dysuria ...
[DOC File]PROTOCOL CONTENTS
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2.5 5 10 20 30 40 50 60 70 80 90 100 Desired dose: mcg/kg/min. 5 * ... Revatio) or other phosphodiesterase inhibitors for erectile dysfunction in the past 24 hours, do not administer nitroglycerin products. CONGESTIVE HEART FAILURE PULMONARY EDEMA-ADULT. Description: Pulmonary edema occurs when fluid from the body accumulates in the lungs and ...
[DOC File]Home Page: Journal of Dermatological Science
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S2 Gavaldà A, Roberts RS. Phosphodiesterase-4 inhibitors: a review of current developments (2010 – 2012). Expert Opin Ther Pat 2013; 23:997-1016. S3 Schafer P. Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochem Pharmacol 2012; 83:1583-90. S4.
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Phosphodiesterase-5 (PDE5) Inhibitors: sildenafil . tadalafil . ... Emtricitabine 5'-triphosphate inhibits the activity of the HIV-1 RT by competing with the natural substrate 2’-deoxycytidine 5'-triphosphate by being incorporated into nascent viral DNA which results in chain termination.
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5. Hansten PD and Horn JR: Hansten and Horn’s Managing Clinically Important Drug Interactions, Vancouver, 1998, Applied Therapeutics, Inc. A manual of specific drug interactions listed by individual drug, and how to manage the toxicities and interactions, not limited to chemotherapy agents.
[DOC File]International Center for Chemical and Biological Sciences ...
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Xanthones Inhibitors of α-glucosidase and Glycation from Garcinia nobilis. Hugues Fouotsa, Alain Meli Lannang, Celine Djama Mbazoa, Saima Rasheed, Bishnu P. Marasini, Zulfiqar Ali, Krishna Prasad Devkota, Augustin Ephrem Kengfack, Farzana Shaheen, Muhammad Iqbal Choudhary, Norbert Sewald, Phytochemistry Letters, 5 (2), 236–239, 2012.
[DOCX File]CURRICULUM VITAE
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32.Synthesis of Epoxy Analogs of Inositol Phospholipids and Their Evaluation as Inhibitors of Phosphatidylinositol-Specific Phospholipase C, Y. Wang, N. K. Bhamare and K. S. Bruzik, National ACS Meeting, Anaheim, April 2-5, 1995.
[DOC File]Zacks Investment Research
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PDE5 inhibitors stop the degradation of cGMP-specific phosphodiesterase type 5 (PDE5), thereby enhancing the vasodilatory effects of nitric oxide. PDE5 inhibitors have been shown to have a favorable effect on increasing exercise capacity and decreasing PAP in PAH clinical studies.
[DOCX File]SUMMARY FINDINGS - Pharmaceutical Benefits Scheme (PBS) …
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ulmonary arterial hypertension (PAH) is a relatively rare disease affecting 15-150 people per million at any one point in time. (1-4) The importance of registry data to characterise the natural history of uncommon conditions such as PAH, with clear potential to monitor the cost-efficacy of new therapeutic strategies, (5) was initially realised in the 1980s when the first PAH-related registry ...
[DOCX File]Ελληνική Ρευματολογική Εταιρεία & Επαγγελματική Ένωση ...
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Bosentan also has a role in the prevention of digital ulcers. Pulmonary arterial hypertension is managed depending on the functional stage of the patient, with endothelin-1 receptor antagonists, phosphodiesterase-5 inhibitors, prostacyclin analogues or combinations of the above.
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