ࡱ> U@ Bbjbj +@2 $L9L9L989:$+,;;L;;;DDD$WR(GBDGG(;; P P PG;; PG PJ PSPTv;; 5wL9H*Fn$0+WI@Wv$$WvhDvET PXEDE5DDD(($$d/2O$$2Purpose: To improve mortality and neurological outcomes in patients who have survived cardiac arrest. The goal of therapy is to achieve and maintain therapeutic hypothermia for a 24 hour period with a target of 33C. Policy: Therapeutic Hypothermia (TH) shall be initiated on all adult cardiac arrest patients with return of spontaneous circulation (ROSC) that fit the inclusion criteria, and does not have any of the following: eye opening to painful stimuli, pre-existing coma, traumatic arrest (either penetrating or blunt), body temperature less than 30C, or an apparent gravid uterus. 1. Therapeutic Hypothermia will be initiated, when possible, pre-hospital. Upon arrival in Emergency Department or post cardiac arrest in DHLC, a  Code Chill will be called through the hospital beeper system. Team will consist of ED Attending or Floor Attending, Intensivist, ICU Attending, ICU Fellow, ICU Code Nurse and nursing supervisor. DHLC nursing will attend in an advisory capacity to facilitate transfer into DHLC system After patient is identified as a candidate, TH will begin immediately in the form of ice packs to axilla, groin and neck. Protocol will follow procedure outline once patient stabilization and therapies (anti-arrhythmics, vasopressors/fluids with target SBP 90-100 mm Hg, and advanced airway management with O2 sat >85%) are implemented. Patient will be moved to the Critical Care Unit or the Cath Lab (for intervention) as soon as possible after stabilization with cooling measures in place. Discontinue cooling and begin active rewarming in the presence of any cardiovascular instability ( i.e. persistent uncontrollable arrhythmias or refractory hypotension), or if patient awakens. Inclusion Criteria: Nontraumatic cardiac arrest with Return of Spontaneous Circulation (ROSC) Cardiopulmonary Resuscitation (CPR) initiated within 10 minutes of cardiac arrest ROSC within 30 minutes of recognition of the cardiac arrest; MAP e" 60 for at least 30 minutes post ROSC with or without vasoactive medication Initiation of Induced Hypothermia begun within 6 hours of collapse Initial body temperature must be greater than 30C No purposeful movement to command and Glasgow Coma Scale < 6 % Age > 18; Female < 50 must have negative urine HCG Exclusion Criteria: Prolonged arrest time longer than 60 minutes or down time without BLS longer than 10 minutes Age less than 18 years Pregnancy Uncontrolled bleeding, thrombocytopenia or other coagulopathy DNR or DNI status Severely impaired pre-arrest cognitive status Other causes of coma (mass lesions, metabolic coma, seizures, drug overdose, head trauma, cerebrovascular accident, etc.) Existing multi-organ dysfunction syndrome; severe sepsis or co-morbidities with minimal chance of meaningful survival independent of neurological status; known terminal illness. Refractory arrhythmias Hypoxemia with Saturation <85% for more than 15 minutes Response to verbal commands after return of spontaneous circulation. Qualifications: Critical Care physicians caring for the patient will write orders for Therapeutic Hypothermia, Admission and assess current medications/therapies for continuation during the protocol. Cardiology, Neurology and Renal consultations should be considered. Critical Care registered nurses will manage/continue the cooling blanket temperature regulation system and initiate hypothermia once patient is within the DHLC system. Education: Training will be provided to staff participating in the care of the selected patients. Family/Patient Teaching: Explain the purpose of therapeutic hypothermia Explain the potential use of other assistive devices (ventilator, IV pumps, monitors, Sportbed, pulse oximetry, cooling blankets) Explain the use of analgesics, sedatives and neuromuscular blocking agents. Procedure/Protocol: Equipment: Cooling Blankets (2) Cooling machine, two sets of hoses and temperature probe cable Obtain Sterile/distilled water for cooling machine from SPD Knee high antiembolism hose and SCDs  Ice packs Rectal temperature probe Foley catheter with temperature probe and drainage system 2 sheets 3 Liters 0.9NS IVF at 4( C Large bore IV catheters, tubings and infusion pumps Cardiac monitor, transducers, pressure system Stocked in ICU Pulse oximetry (forehead) Hands free defibrillator pads Sportbed with rotation OGT/NGT and LCS Procedure: The provision of therapeutic hypothermia to survivors of cardiac arrest consists of three phases: Induction, Maintenance and Rewarming. This section will outline in detail the steps to be taken. Specific order sheets and checklists are available. Check orders to address specific interventions for the following complications of hypothermia: shivering, hypotension, hypokalemia, hypomagnesemia, and hypocalcemia. Once patient has been determined to be a candidate, proceed with Induction phase. If patient has STEMI on EKG, consult cardiology and consider thrombolytic therapy/PCI/ASA administration Induction with Intravenous Cold Saline and Cooling Blanket If temperature 30-33( C, allow patient to warm to 33( C Insert arterial line Insert CVC (consider PreSep catheter) Attach rectal temperature probe to cooling machine. Secondary temperature probe (foley or other central temp) will be used to correlate cooling temperature probe. Begin IV cold crystalloid as soon as patient is identified and place ice packs in patients axilla and groin while cooling blanket is being readied. 0.9NS at 4( C is stored in designated refrigerator in the ICU. All fluids used during the cooling and rewarming phase should be dextrose free Follow as ordered either No Cardiac Shock protocol or Cardiac Shock/LV Failure/low EF protocol for cooling therapy. No Cardiac Shock protocol Infuse 1500 ml 4( C 0.9NS over 30 minutes If core temperature remains > 34.5( C, infuse an additional 500 ml over 30 minutes Repeat 500 ml infusions until core temperature ( 34.5( C to a maximum of 30 ml/kg total Cardiac Shock/LV failure/low EF is present: Infuse 1500 ml 4( C 0.9NS over 60 minutes If core temperature remains > 34.5( C, infuse an additional 500 ml over 30 minutes Repeat 500 ml infusions until core temperature ( 34.5( C to a maximum of 30 ml/kg total If unable to obtain target core temperature within 5 hours, contact provider Completely expose patient and place cooling blankets above and below patient with a sheet between patient and cooling blanket Attach both blankets to the cooling machine. Set cooling machine to autocontrol and goal temperature to 33(C Once patient reaches 34(C, allow patient to drift down to goal temperature of 33(C Be alert for early signs of shivering and initiate shivering protocol Maintenance with Cooling Blanket Machine Acetaminophen 650 mg OGT/NGT/PR Q 6 hours during induction and maintanence; Q 4 hr. PRN during re-warming phase and for a temperature > 37(C after warming. Clamp NG/OG tube for 30 minutes after administration. Maintain patient temperature at 33( C for 24 hours from initiation of cooling. If patient is in pain or agitated, medicate with as ordered; otherwise sedation should be limited to facilitate frequent neurologic exam checks. If shivering develops see shivering orders If hypotension develops (MAP ( 80 mmHg) see BP & Volume Management orders If hypokalemia develops see electrolyte replacement orders If dysrhythmia or bleeding develops see rewarming phase below Maintenance of therapeutic hypothermia should be provided with cooling blankets and if temperature > 33.5( C, infuse an additional intravenous 4(C 0.9NS bolus of 250 ml Q 10 minutes until temperature < 33.5(C. Replace urine output every hour with 0.9NSS in a ratio of 1:1 or 0.5:1 BP & Volume Management For patients on the therapeutic hypothermia protocol who develop hypotension (MAP ( 80 mmHg) the following steps should be attempted: Assess for medical causes of hypotension Adjust/titrate down any analgesic/sedative/shivering medications. If shivering, consider neuromuscular blockade Observe closely for fluid overload Initiate Vasopressors if MAP continues ( 80 after fluid resuscitation Hypertension: For patients on the therapeutic hypothermia protocol who develop hypertension (MAP > 100 mmHg), consult orders for initiation of NITROglycerin IV. Electrolyte Replacement Have provider evaluate electrolyte replacements if serum creatinine is > 2 mg/dl Check STAT potassium and magnesium for any cardiac dysrhythmia and every 4 hours After any replacement, check electrolyte level 1 hr after completion of replacement. During cooling phase: replace K+ < 3.5 replace Mg++ < 2.0 replace ionized Ca++ < 1.0 or serum Ca++ < 7.5 Discontinue K replacements 8 hours prior to rewarming Discontinue Mg and Ca replacements once warming has begun Analgesia/Sedation and Shivering Use Numeric, Faces or FLACC scale for pain assessments with a goal of less than 3 or minimal pain behaviors. Refer to orders for analgesia orders. Propofol or Dexmedetomidine will be utilized to maintain a RASS (Richmond Agitation Sedation Scale) score of -3. Buspirone, Acetaminophen, Midazolam, and/or Neuromuscular Blocking Agents (NMBA) will be administered on an as needed basis to prevent shivering and maintain the BSAS (Bedside Shivering Assessment Scale) a score of 0. DVT Prophylaxis Utilize antiembolic hose and sequential compression devices Administer Enoxaparin unless patient on heparin. PUD Prophylaxis Administer Famotidine as ordered Blood Product Transfusion Blood Warmer is required when cold agglutinins are present (see comments on the transfusion tag). Rewarming The rewarming process should be gradual and take place ideally over 12 or more hours. For patients with severe bleeding despite measures recommended in the BP & Volume Management section, a rapid active rewarming process should take place over 8 hours. Standard Rewarming Protocol Cooling Blanket Monitor for hyperthermia, hypotension and hyperkalemia May discontinue paralytics when temperature is 36( C Consult Neurology services once normothermia (37( C) has been achieved Once a temperature of 37( C is reached, leave a cooling blanket on top of the patient with machine set to 37( C for the remainder of the 48hr period of therapy to avoid rebound hyperthermia Target is 37( C over approximately 12 hours at a rewarming rate of 0.33( C/hour Manually increase temperature setting on the cooling machine by 1.0( C every 3 hours. If the patient develops severe bleeding, the patient should be actively rewarmed according to the following protocol: Active Rewarming Protocol Cooling Blanket Target temperature is 37( C over approximately 8 hours at 0.5( C/hour Manually increase temperature setting on cooling machine by 0.5( C every hour Discontinue paralytics when temperature is 36( C if appropriate. Nursing Interventions Review Appendix A: Physiologic Effects of Hypothermia Accurate weight should be obtained as soon as patient arrives in ICU. Infusion therapies, vasopressors and vasodilators may effect heat transfer, increase potential for skin injury and contribute to adverse hemodynamic response The cooling system requires a dedicated rectal temperature probe; correlate with a secondary temperature probe (foley or CVC) and monitoring of the water temperature setting on cooling device. The heater on the ventilator should be turned off and room temperature should be lowered to facilitate cooling. % Assess rectal, foley and water temperature setting every 15 minutes during induction of hypothermia and rewarming, and every 30 minutes during maintenance. % All hemodynamic values and signs are recorded hourly Arterial line or NIBP is required for BP monitoring Place the patient on continuous cardiac monitor Lab work: (CBC, Chemistry Panel, Amylase, Lipase, Lactate, Cardiac Enzymes (CK, CK-MB, Troponin I) Coagulation profile (PT/INR/PTT), ABG with ionized Ca++. Reassess at 12 and 24 hrs. Potassium and magnesium levels will be monitored every 4 hours. Consider blood cultures with rewarming. Assess glucose every 4 hours and obtain order for the IV Insulin Infusion Protocol for BS > 150. (Sub-cu insulin should not be given.) Assess baseline LOC and neurological status (Glasgow Coma Scale and TOF, document on Sedation Flowsheet) Assess ventilatory function, because of vasoconstriction, pulse oximetry can be unreliable; use forehead when possible. Assess Continuous ETCO2 monitor to maintain ETCO at 35-45. Observe VAP bundle (HOB elevated > 30 degrees, oral care, peptic ulcer disease prophylaxis, DVT prophylaxis) with exception of sedation weaning and assessment of readiness to wean until after neurological evaluation when rewarmed Assess GI function, abdomen, bowel sounds Assess skin integrity. External cooling devices can cause or exacerbate skin injury in patients without intact skin. Skin check areas covered by cooling blankets every hour. Assess for signs of shivering: palpate masseter, deltoids and pectoralis muscles for vibration. Observe skeletal muscle movement that may be first detected as ECG artifact. Hands, head, and feet should be covered with socks or blankets to help reduce shivering. No bathing of patients during therapeutic hypothermia protocol Apply antiembolism hose (knee) and sequential compression devices Utilize Sport Bed with rotational therapy Assess urine output and utilize replacement fluids as ordered Utilize hands free defibrillator pads for arrhythmia management Do not pull any lines until patient warming is completed. No subcutaneous injections (except Lovenox) should be given until patient is rewarmed. Report the following to provider: Loss of oxygen saturation signal Inability to reach or maintain target temperature Inability to control shivering Deterioration in coma scale level Loss of bowel sounds ECG changes Cardiac arrhythmias HR < 50 or > 120 Urine output < 0.5 ml/kg/hr Related Policies/Documents: Pharmacy: Guidelines for Medication Administration via Feeding Tubes ACM 23: Pain Management PCS A-7: Application of Antiembolism Stockings PCS C-5: Use of Pneumatic Compression Sleeve PCS B-7.1: Blood and Blood Product Transfusion Neurovascular Flowsheet (Glasgow Coma Scale) RASS (Richmond Agitation-Sedation Scale) BSAS (Bedside Shivering Assessment Scale) IV Insulin Protocol VAP Bundle Physiologic Affects of Hypothermia (Appendix A) Blanketrol II Instructions Appendix A. Physiologic Effects of Hypothermia (Adapted from Burns, S. (2001). Revisiting Hypothermia: A Critical Concept. Critical Care Nurse, 21 (2) 83-86) Cardiovascular Ventricular arrhythmias (hypothermic patients are more susceptible to atrial and ventricular fibrillation). Myocardial depression, bradycardia, angina Increased SVR, decreased CO, decreased contractility (hypothermia has a negative chronotropic effect on pacemaker tissue, which may lead to bradycardia or AV block). Increased PR, QRS, QT intervals Hypothermia may cause repolarization abnormalities, producing ST segment elevation and T-wave inversion. Respiratory Decreased RR (hypoventilation, suppression of cough, and mucociliary reflexes associated with hypothermia may lead to hypoxemia, atelectasis and pneumonia.) Shift in oxyhemoglobin dissociation curve to the left (less oxygen is released from oxyhemoglobin to the tissues) Decreased cough & increased secretions Metabolic Decreased basal metabolic rate (hypothermia inhibits insulin release from pancreas, but glucose levels remain normal in mild HT because shivering increases glucose utilization. Shivering increases metabolic rate, CO2 production, O2 consumption and myocardial work). Decreased drug biotransformation Decreased tissue perfusion Gastrointestinal Decreased motility, liver function, insulin release Ileus Stress ulceration Renal Decreased renal plasma flow, Decreased urine output Increased specific gravity Decreased ADH Hematologic Increased blood viscosity (hemoconcentration) Platelet dysfunction Neurologic Confusion Coma Decreased LOC, decreased reflexes, decreased muscular tone Appendix B. Hypothermia Protocol Flow Sheet     Yes No       Therapeutic Hypothermia Protocol 9/25/10 DB Page  PAGE 9 of  NUMPAGES 9 Post Cardiac Arrest Induced Hypothermia Protocol and Procedure Deborah Heart and Lung Center Therapeutic Hypothermia Working Group Page  PAGE 1 of  NUMPAGES 9 Insert Arterial Line Insert CVC STEMI: consider TNK / Heparin / PCI / ASA. 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N gdukgdukKRLRRRSRTRURYRZRdReRfRgRiRRRRRRRRRRRRSS SSSSSSDSGSHSISJSQSRSSSTSWSXSYSZS]S^S_S`SeSʺ󶥗}hh5CJaJhRCJOJQJ^JaJhVrCJOJQJ^JaJ hhCJOJQJ^JaJhlhCJ(aJ(hQCJ(aJ(hBShN>CJ(aJ(jhN>U*hlmHnHu*hlmHnHuhN>jhN>U1eSfSSS!_qr  & F, h@d1$7$8$H$gd` id@1$7$8$H$^gd{gd & F&d1$7$8$H$gd8dL1$7$8$H$^8`gd7QeSfSpSxSySSS!&q庣s`M6-hh{B*CJOJQJRHF^JaJph%hh7QB*OJQJRHF^Jph%hh{B*OJQJRHF^Jph-hLUAh7Q@B*CJOJQJ^JaJph-hh?9@B*CJOJQJ^JaJphU-hh7Q@B*CJOJQJ^JaJph-hh7QB*CJOJQJRHE^JaJph'h?9B*CJOJQJRHE^JaJph-hhB*CJOJQJRHE^JaJphhN>Age less than 18 years Pregnancy Uncontrolled bleeding, thrombocytopenia or other coagulopathy DNR or DNI status Severely impaired pre-arrest cognitive status Other causes of coma (mass lesions, metabolic coma, seizures, drug overdose, head trauma, cerebrovascular accident, etc.) Existing MODS; severe sepsis or comorbidities with minimal chance of meaningful survival independent of neurological status Refractory arrhythmias INCLUSION CRITERIA Nontraumatic cardiac arrest with Return of Spontaneous Circulation (ROSC) Cardiopulmonary Resuscitation (CPR) initiated within 10 minutes of collapse ROSC within 30 minutes of recognition of the cardiac arrest; MAP e" 60 for at least 30 minutes post ROSC with or without vasoactive medication Initiation of Induced Hypothermia begun within 6 hours of collapse Initial body temperature must be greater than 30(C No purposeful movement to command and Glascow coma Scale < 6 If Temp >34.5( C and no cardiac shock present: infuse 1500 ml of 4(C 0.9 NSS over 30 min and repeat 500 ml infusions until core temp < 34.5(C or max of 30 ml/kg If Temp > 34.5(C and cardiac shock /LV failure/low EF present: infuse 1500 ml of 4(C 0.9 NSS over 60 min and repeat 500 ml infusions until core temp < 34.5(C or max of 30 ml/kg Initiate cooling with cooling blanket with target temperature 33( C x 24 hr Rewarming: After 24 hr. increase temperature 0.33( C every hour May discontinue NMBA and then wean sedation when patient temp reaches 36(C Maintain patient at 37( C for the remaining 24 hours of therapy Order: Acetaminophen 650 OGT/NGT/PR Q 6 h x 24 h, then Q4 h prn temp > 37( C Buspirone 30 mg OGT/NGT Q 8 h x 24 h PVD prophylaxis PUD prophylaxis Analgesia Sedation assessment and interventions Shivering assessment and interventions Electrolyte replacements BP and volume management Lab work Active Rewarming: Discontinue protocol and actively rewarm at 0.5( C per hour if patient develops hemodynamically unstable arrhythmias; sustained MAP < 60 x 15 min. after resuscitation, severe bleeding, or awakens. 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" # $ % & ' ( ) * + , - . / 0 1 2 3 Oh+'0$ 4@ \ h t 1Post Cardiac Arrest Induced Hypothermia Protocol.0ost kisners-603isnisnNormal-MCN-6244N-Microsoft Word 10.0@캃@v@,@w 7Root Entry F`VData p1Tablex3WordDocument+ SummaryInformation(DocumentSummaryInformation8lCompObjj  FMicrosoft Word Document MSWordDocWord.Document.89q՜.+,D՜.+,t0 hp  Deborah Heart & Lung Centeru!@{ 1Post Cardiac Arrest Induced Hypothermia Protocol Title@80_AdHocReviewCycleID_EmailSubject _AuthorEmail_AuthorEmailDisplayName_ReviewingToolsShownOnce_PreviousAdHocReviewCycleIDkHarrisV@Deborah.org>ε:Penn Alliance for Therapeutic Hypothermia (PATH) DatabaseHarris Valerie, Cardiac Cath  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnoqrstuvwyz{|}~