ࡱ>   bjbj 4dd#jj:::::NNNN$rN?v7>/8C8 ???????,mBE0?]:O87@7O8O80?:::?:::O8V::?:O8?::=>I:F=>?0?=,E:E>::>O8O8O80?0?:O8O8O8?EO8O8O8O8O8O8O8O8O8j :   Syllabus for Fall 2015 Molecular Genetics: Biology 700.4/700.5 Class: Tuesday and Thursday 6:30-8:20 PM (5 credit h) Science Building D346  Contact information: AM: Dr. Alicia Melndez (course head)  HYPERLINK "mailto:alicia.melendez@qc.cuny.edu" alicia.melendez@qc.cuny.edu  NSB D-338, phone 718 997-4580 CSD: Cathy Savage-Dunn  HYPERLINK "mailto:Cathy.SavageDunn@qc.cuny.edu" mailto:Cathy.SavageDunn@qc.cuny.edu NSB D-330, phone 718 997-3440  Required Texts: 1. Walker, M. and Hawley, S. (2003) Advanced Genetics Analysis, Blackwell Publishing. 2. WORMBOOK, ( HYPERLINK "http://www.wormbook.org/toc_complete.html" http://www.wormbook.org/toc_complete.html) a comprehensive collection of original peered reviewed chapters covering topics related to C. elegans biology. 3. Papers from the primary literature: There will also be a series of scientific papers to read, some are announced on the syllabus and others will be announced as needed throughout the semester on Blackboard. Recommended Texts: 1. Hartwell, L. et al (2008) Genetics: From Genes to Genomes, 5th edition, McGraw This edition no longer includes sections on model organisms for genetic research, but these are available online at the HYPERLINK "http://highered.mcgraw-hill.com/classware/infoCenter.do?isbn=0072848464"McGraw-Hill web site. Registration is simple. ( Complete Information: ( "Genetics: From Gene to Genomes"( LelandHartwell, LeroyHood, MichaelGoldberg, AnnReynolds, LeeSilver, and RuthVeres.( ISBN: 0072848464 2008( ( HYPERLINK "http://catalogs.mhhe.com/mhhe/viewProductDetails.do?isbn=0073227382"McGraw-Hill, the publisher's web site. ( HYPERLINK "http://www.amazon.com/Genetics-Genes-Genomes-Leland-Hartwell/dp/0073227382/ref=pd_bbs_sr_1/002-5008744-7778403?ie=UTF8&s=books&qid=1184208692&sr=1-1"Amazon. Objectives: After taking this course, you should -Understand the basic mechanisms of transmission of genetic traits, as first described by Mendel. -Understand how genetic research is carried out, how we use genetic techniques to answer biological questions. -Understand how epistasis analysis is carried on, and how modifying genes may work: suppressors and enhancers. -Understand and recognize the differences involved using different genetic model organisms. -Understand how to problem solve and how to analyze data from genetic analyses. -Be able to read an article from the primary literature and understand the genetics described, and be able to evaluate its conclusions. Coverage: This course is intended as an advanced course in genetic analysis. The focus is on the basic principles that underlie genetic analysis: the nature of mutations, complementation, suppression, enhancement, recombination, segregation, and gene regulation. Our goal is to provide insights into the process of genetic analysis and how this functions in the study of a biological process. We discuss the basic tools, current techniques of genetic analyses, and the different genetic model organisms: the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and mouse Mus musculus. For each of these species we will consider methods for the identification of informative mutations revealing new genes or new gene functions, and methods for testing the expression of modified genes. Genomics, including applicable genomics resources and practical bioinformatics tools, will also be covered. Articles from the primary literature to better understand new techniques, and possible misunderstandings in genetic analysis are also discussed. The course assumes familiarity with the genetics of eukaryotes, and working knowledge of molecular biology, as for example transcription, splicing, translation, and replication. Grading for Bio 700 Students The final grade for will be calculated as follows: Quizzes 50% (Students have the option of dropping 2 quizzes from the 12 total quizzes) Presentation 20% Final Exam 30% Makeup Policy There will be no makeup exams given under any circumstances. Student Disability Services To receive disability-related academic accommodations students must first be registered with the Center for Student Disability Services. Students who have a documented disability or suspect they may have a disability are invited to set up an appointment with the Director of the Center for Student Disability Services, Ms. Mirian-Detres Hickey at 718-997-5870, or they can walk-in and make an appointment at Frese Hall, room 111. If you have already registered with the Center for Student Disability Services please provide your instructor with the course accommodation form and discuss your specific accommodation with him/her. University's Policy on Academic Integrity The faculty and administration of Queens College support an environment free from cheating and plagiarism. Each student is responsible for being aware of what constitutes cheating and plagiarism and for avoiding both. An example would be to use exact words or figures from a source without attributing those words to the author or the source. The complete text of the CUNY Academic Integrity Policy and the Queens College procedure for implementing that policy can be found at this site:   HYPERLINK "http://www.qc.cuny.edu/about/administration/Provost/Policies/Documents/Academic Integrity Memo Fall 2014.pdf" http://www.qc.cuny.edu/about/administration/Provost/Policies/Documents/Academic Integrity Memo Fall 2014.pdf If a faculty member suspects a violation of academic integrity and upon investigation, confirms that violation, or if the student admits the violation, the faculty member MUST report the violation. The penalty for violation will be failure in the course and a report to the Office of Student affairs. Calendar: DateLectu rerTopicHartwellHawleyArticles/OtherTh 8/27AM1. Intro: Genes to GenomesCh. 4 Tue 9/1CS2. DNA manipulation Techniques Ch. 9Problem Set 1 due (Intro Genetics)Th 9/3CS3. Using Genetics- Mutations Quiz 1: Intro and DNA techniquesOn line Ch. C. elegans Ch. 7, 8Ch. 1, p.1-14, and p. 31-50Tue 9/8CS4. Genetics- Mutations DiscussionProblem Set 2 due (Mutations) Article 1 for discussion Th 9/10NO CLASS Mon Schedule Tue 9/14NO CLASS College ClosedTh 9/17AM5. ComplementationCh. 8Ch. 3WB: Complementation Tue 9/22NO CLASS College Closed Th 9/24AM6. DNA mutation and Repair Quiz 2: Mutations Ch. 7Ch 2WB: DNA repair WB: Replication and Repair Problem Set 3 due (Complementation) Fri 9/25CS7. Chromosome Quiz 3: ComplementationCh. 5,6Ch. 8Tue 9/29CS8. Genome Rearrangements Ch. 12Article 2 for discussion Th 10/1CS9. Recombination Quiz 4: Chromosome and Genome RearrangementsCh. 6Ch. 7Article 4 for discussion WB: Transposons in C. elegansTue 10/6AM 10. Mapping and Cloning- DiscussionCh. 10Ch. 6,7WB: Mapping Article 3 for discussion Problem Set 4 due (MappingTh 10/8CS11. Transposons-Discussion Ch. 12Tue 10/13AM12. Suppressors Quiz 5: Mapping and CloningCh. 12Ch. 4WB: Genetic Suppression Problem Set 5 due (Transposons)Th 10/15AM 13. Enhancers and Redundancy- WB: Genetic Enhancers WB: Gene duplications and Redundancy WB: LIN-12/Notch signaling Redundancy articleTue 10/20AM14. Suppressors and Enhancers DiscussionProblem Set 6 due (Suppressors & Enhancers) Article 5 for discussionTh 10/22AM15. Epistasis Quiz 6: Suppressors and Enhancers Ch. 5, p. 107-118WB: Epistasis Tue 10/27AM16. Epistasis- Discussion Problem Set 7 due (Epistasis) Article 6 for discussionTh 10/29CS17. Gene Regulation Quiz 7: Epistasis Ch. 15, 16Tue 11/3CS18. Gene Regulation Discussion  Problem Set 8 due (Gene Regulation) Article 7 for discussion Th 11/5AM19. RNAi and CRISPR/Cas Quiz 8: Gene RegulationCh. 16RNAi articles and CRISPR/Cas articlesTue 11/10AM20. RNAi and CRISPR/Cas- Discussion Problem Set 9 due (RNAi) Article 8 and 9 for discussion Th 11/12CS21. Epigenetics Quiz 9: RNAi?@FGNS[hnru   ԸԢ|pdUdHdh_^h_^0JOJQJjh_^OJQJUjh_^OJQJUh_^h_^5OJQJh_^h_^aJh\)h_^OJQJh\)h_^5OJQJ hPCJjh_^UmHnHuh_^OJQJh5dOJQJh OJQJh\)hP75OJQJh\)hP7OJQJh_^hP75CJ OJQJaJ h_^hzz5CJ OJQJaJ ?@; < T 5    gd_[gdP7 Pgd_^gd_^ <d]^gd_^d8gdP 6$$ 6$a$$a$ . 2 < R S T U  ϙ퍄vg\SG<h\)h_[OJQJh\)h_[5OJQJh_[5OJQJh_^h_[OJQJh_[5OJQJ\^JaJjh_^UmHnHuh7hhPCJh\)h_^5OJQJ$h_^h_^0JOJQJ^J_H aJ)jh_^OJQJU^J_H aJh_^OJQJ^J_H aJ#jh_^OJQJU^J_H aJh_^h_^5OJQJh_^OJQJh\)h_^OJQJ  5 6 8 @ C D { | }       ? ǹth_S?_&h\)hP75OJQJ\^J_H aJ h\)hP75OJQJh_[5OJQJh\)hP76OJQJ!h\)hP70JB*OJQJphjph\)hP7>*Uh\)hP7>*OJQJjh\)hP7>*Uh\)hP7OJQJh\)hP75>*OJQJ"h\)hP75OJQJ\^JaJh_[5OJQJ\^JaJh\)h_[OJQJh\)h_[>*OJQJ      < > ? B R   4 5 B轱蝅jR:R/h\)h_[5>*OJQJ\^J_H aJ wh /jh\)h_[5OJQJU\^J_H aJ 5j5h\)h_[5OJQJU\^J_H aJ /jh\)h_[5OJQJU\^J_H aJ &h\)h_[5OJQJ\^J_H aJ h\)h_[H*OJQJh_[OJQJh\)h_[>*OJQJh\)h_[56OJQJh_[5OJQJh\)h_[OJQJh\)h_[5OJQJBjl  $&`bڭڭzhXKXzh OJQJ\^JaJh\)hP7OJQJ\^JaJ"h\)hP75OJQJ\^JaJh\)hP7OJQJh\)h_[OJQJ\^JaJ/j/h\)h_[OJQJU^J_H aJ )h\)h_[>*OJQJ^J_H aJ wh /j6h\)h_[OJQJU^J_H aJ )jh\)h_[OJQJU^J_H aJ h\)h_[OJQJ^J_H aJ  pNxy 1@AO]gdR\gdP 'gd gdP7 gd_[|4xy@AO]_嵥tbNb:&h\)hP>*CJ OJQJ\^JaJ&h\)hP5>*CJ OJQJ^JaJ#h\)hP>*CJ OJQJ^JaJ#h\)hP5CJ OJQJ^JaJhP5CJ OJQJ^JaJh\)hP7OJQJ\^JaJh\)hP75OJQJ^JaJh\)hP7OJQJ&h\)hP76OJQJ]^J_H aJ h\)hP7OJQJ^J_H aJ h\)hP7&h\)hP75OJQJ\^J_H aJ Ⱥȴwlh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\aJhR\@aJ hR\aJh7hhR\5@\aJh7hhR\5\aJh7hhR\5@\aJh7hhR\5@\aJhR\>*CJ OJQJ^JaJ*    !"&')*,.023478;<?@ABDEFGIJLMh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\aJh7hhR\@aJGMNOPUVZ[_`defghjklmnopqrsuvwx{|h7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\aJ> XY쉃xh7hhR\@aJ hR\aJh7hhR\@"aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@ aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@!aJh7hhR\aJh7hhR\@aJ/YZ[\^_`acdefijklmnoruvw{|˵~sssh7hhR\@-aJh7hhR\@0aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@)aJh7hhR\@aJh7hhR\@/aJh7hhR\@aJh7hhR\@.aJh7hhR\@aJh7hhR\@2aJh7hhR\aJ+씵h7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@aJh7hhR\@&aJh7hhR\aJh7hhR\@aJ:   !"$&()-.126789:<=?@ABDEFGHIMNOھھڰھڢھ̰ھ̾ھڋuh7hh_[@aJh7hh_[@aJh7hh_[aJh7hh_[5@\aJh7hh_[5@\aJh7hh_[5@\aJh7hh_[5@\aJh7hh_[5@\aJh7hh_[5\aJ hR\aJh7hhR\@aJh7hhR\aJ, J4!##&#+#1#5#;#D#K#Z#$$Ifa$l $@&Ifl $@&Ifl $ Pd=]Pa$gdP Kd]Kgd_[]gd_[]gdR\OPQSTVWZ[_`bdhilrstwxy֭h7hh_[@aJh7hh_[@aJh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[aJh7hh_[@aJh7hh_[@aJD  $%&'()*+/05689;<=?@ABDEFh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[aJh7hh_[@aJh7hh_[@aJGFHIKLOPQRSTUVWY[\]^abcdelmnpq~h7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[aJCֵyh7hh_[@aJh7hh_[@aJh_[@aJh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[aJ/   $%&'(,-013   !!!!!!!!!!!!!}h7hh_[@aJhPhP0JjhPUhPjhPU h_[h_[ hPaJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[aJ.!!!!!!""""""""""""$"%"&"'"(")"+","."0"7"8";"<"="C"D"F"G"H"I"K"L"N"O"P"Q"U"V"["\"^"_"a"b"e"f"j"k"m"n"##ֵ֪֟h\)hP7OJQJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[@aJh7hh_[aJh7hh_[@aJh7hh_[@aJh7hh_[@:aJ<#%#&#*#+#0#1#3#4#5#:#;#C#D#J#K#Y#Z#[#b#c#e#f#########################$$$($)$5$ΤΤΛ各h\)h\)5OJQJh\)h\)OJQJhu 5OJQJh\)h 5OJQJ h\)h h\)hshCOJQJh\)h 5h\)hP75OJQJh\)hiOJQJh\)hP7OJQJ h\)hP7h\)hP754Z#[#c#>($1$7$8$H$Ifl kd%$$Iflֈh^>+Pv0&-4 laytCc#f#####$Ifgdsl $Ifl $$Ifa$l ###>($1$7$8$H$Ifl kd$$Iflֈh^>+Pv0&-4 laytC######$Ifl $$Ifa$l ###>($1$7$8$H$Ifl kd$$Iflֈh^>+Pv0&-4 laytC##)$5$@$I$e$f$$IfgdP7l $Ifl $$Ifa$l 5$@$B$C$H$I$d$f$g$n$o$q$r$$$$$$$$$$$$$$$$$$$$$$$$$迳٧}rfr^ *h\)hP7h\)h[5OJQJh\)h[OJQJh[5OJQJhh[5OJQJhu 5OJQJh\)h 5OJQJh\)hP75OJQJhCghP75OJQJh;OJQJ h\)h h\)hsOJQJ h\)hP7hsOJQJh\)hP7OJQJh\)hP76OJQJ$f$g$o$>($1$7$8$H$Ifl kdt $$Iflֈh^>+Pv0&-4 laytCo$r$$$$$$$$$Ifgd[l $Ifl $Ifgd;l $$Ifa$l $$$>($1$7$8$H$Ifl kd9 $$Iflֈh^>+Pv0&-4 laytC$$$$$$$$$%%%%%#%&%Ff$IfgdP7l $1$7$8$H$Ifl Ffl $Ifl   $Ifl $$Ifa$l $%%%%"%#%%%&%)%8%9%=%>%?%D%E%I%X%Y%Z%[%\%d%f%%%%%%%%%%%%%%%%%}qj h\)h;h\)hrA5OJQJh[OJQJh\)hOJQJhCgOJQJh;OJQJh)5OJQJhh)5OJQJh)OJQJh\)h)OJQJhsh\)hrAOJQJhrAOJQJh xOJQJ h\)h h\)hP7h\)hP7OJQJ(&%9%?%E%Z%[%$Ifgd)l $Ifl $Ifgdsl $IfgdrAl [%\%kd$$Iflֈh^>+Pv0&-4 lap<ytC\%e%f%%%%%%%%%%%%%%$Ifgd)l $Ifgd;l   $IfgdrAl FfJ$Ifl $$Ifa$l $1$7$8$H$Ifl %%%%%%%%%%%&&&&&& &"&$&%&ƶ}n_XPHP=h\)h\OJQJh,OJQJh\OJQJ h\)h h;hP7OJQJmH sH h;hrAOJQJmH sH h\)h;OJQJmH sH hu 5OJQJmH sH h\)hu 5OJQJmH sH h)5OJQJmH sH h\)h)5OJQJmH sH h)OJQJmH sH h\)h)OJQJmH sH hrAh[ h\)hP7hrAOJQJhsOJQJ%%&&$Ifl $Ifgd)l && &%&>(($1$7$8$H$Ifl kdW$$Iflֈh^>+Pv0&-4 laytC%&'&)&+&6&<&=&M&N&R&U&V&[&\&]&^&f&g&i&j&k&m&&&&&&&&&&&&ɺvj[h[h,OJQJmH sH hCgh,5OJQJhh,5OJQJ *h\)h\)h\)h,OJQJh,OJQJ h\)hP7h\)hP7OJQJh\)h\mH sH h\)h\OJQJmH sH h\hrA h\)h;h\)h;5 h;5h\)h\OJQJh\OJQJh;OJQJ %&(&6&N&V&\&]&$Ifgd)l $Ifl $Ifgd[l   $Ifgd\l   $Ifgd;l $$Ifa$l ]&^&kd*$$Iflֈh^>+Pv0&-4 lap<ytC^&g&j&&&&&&&ub$Ifgd\l $Ifgd,l $Ifl $Ifgd[l   $Ifl   $Ifgd,l $$Ifa$l $1$7$8$H$Ifl &&&&&&&&&&&&&&&&&&''''+'5'6'7'?'@'B'C'D'[']'^'¹ҞҞҎ‚{shc^h¢VhOOJQJ hk15 h,5h\)hk1OJQJhk1OJQJ h\)h hl7 h,6OJQJh[h,5OJQJhrAh,h\)h,OJQJh\)h,5OJQJh,5OJQJh,OJQJh;OJQJ h\)hP7h\)hP7OJQJh\)h mH sH h\)hP75OJQJmH sH !&&kd.$$Iflֈh^>+Pv0&-4 lap<ytC&&&&&&&'6'$Ifl $Ifgdsl   $Ifgd,l $Ifgd,l $$Ifa$gdP7l $1$7$8$H$Ifl 6'7';'@'>(($1$7$8$H$Ifl kd2$$Iflֈh^>+Pv0&-4 laytC@'C'^'i'p'x''''$Ifgd,l $IfgdPl $IfgdP;l $$@&Ifa$l ^'h'i'm'o'p't'v'w'x'''''''''''''''''''''''ʾ݈|tha]hP h\)h,hPh,5OJQJh\)hP75 h,5 h\)hP7h\)hP7OJQJh\)hk1OJQJh\)h,5OJQJh,5OJQJh\)h,OJQJh[h,5OJQJhCh,OJQJmH sH hrA h\)hk1h,hk1 hl7 hk1hCgh,5OJQJ'''<&$1$7$8$H$Ifl kd$$Iflֈh^>+Pv0&-4 laytC'''''''$Ifgd l $Ifl $IfgdPl $IfgdP;l $@&Ifgd,l $$@&Ifa$l '''''''' (((%(&(,(-(2(3(7(K(\(j(k(l(t(x(y({(}((ѽڛڐ|sh\Qh;hDeOJQJh\)h5OJQJh\)hl7 OJQJhDe5OJQJhChDe5OJQJhDeOJQJh\)hDeOJQJhDehP h\)h\) h,5 h\)h, hPh,h\)h,5OJQJh\)hP75h,5OJQJ h\)hP7h\)hP7OJQJ h\)h h\)hP75OJQJ'''<&$1$7$8$H$Ifl kd$$Iflֈh^>+Pv0&-4 laytC'' (&(-(3(K(k($IfgdDel $Ifl $@&Ifgd,l $$@&Ifa$l k(l(u(>($1$7$8$H$Ifl kd$$Iflֈh^>+Pv0&-4 laytCu(x(((((((()$Ifl $@&Ifgdk1l $IfgdDel $$Ifa$l  (((((((()))))))3)=)>)@)Q)k)l)m)u)w)))))))))ƾƠ󐄐xηpep]hrAOJQJh\)h\OJQJh;OJQJh[hDe5OJQJhhDe5OJQJhDe5OJQJ h\)h\)hTrthDe5OJQJh\)hP7OJQJ h\)h hChP75hDeOJQJ h\)hP7h\)hP75OJQJ h\)hDeh\)hDeOJQJh\)hDe5OJQJ ))kd\$$Iflֈh^>+Pv0&-4 lap<ytC)))>)?)@)m))$Ifl $IfgdDel $$Ifa$l $1$7$8$H$Ifl ))))>(($1$7$8$H$Ifl kd`$$Iflֈh^>+Pv0&-4 laytC)))))))))$IfgdDel $Ifl $Ifgd) l $IfgdrAl $$Ifa$l ))))))))))))))))))*******$*1*8*9*:*I*J*K*תע}ui`T`hh) 5OJQJh) 5OJQJh\)h) 5OJQJh\)hP76 h\)h\) h\)h) hTrth) 5OJQJh\)h) OJQJh) OJQJhCh\)h\OJQJh;OJQJ h\)h h\)hP75 h\)hrA h\)hP7h\)h\)OJQJhCghrA5OJQJh\)hrAOJQJ ))))>(($1$7$8$H$Ifl kd%$$Iflֈh^>+Pv0&-4 laytC))****1*J*$Ifl $IfgdDel $Ifgd) l $$Ifa$l J*K*T*.$1$7$8$H$Ifgd;l kd$$Iflֈh^>+Pv0&-4 lapytCK*L*M*N*S*T*W*Y*[*k*q*s*|*}******************************+++ + ++++榡ՉhOOJQJhCgh) 5OJQJhh) 5OJQJ h) 5h(Dhh) 5h) h*h) 5OJQJh*h) OJQJh\)h) 5OJQJh) 5OJQJh\)h) 5 h\)h) h) OJQJh\)h) OJQJ2T*W*k*~*****$Ifl $@&Ifgd) l $Ifgd) l $$@&Ifa$l **kd$$Iflֈh^>+Pv0&-4 lap<ytC**********$Ifl $Ifgd) l $IfgdDel $@&Ifgd) l $$Ifa$l $1$7$8$H$Ifl  **+3$1$7$8$H$Ifgd;l kd $$Iflֈh^>+Pv0&-4 lapytC+++7+>+?+e+$IfgdDel $1$7$8$H$Ifgd4ul $Ifgd4ul $Ifgd) l $$Ifa$gd4ul +&+6+7+8+:+=+?+d+e+f+o+p+r+s+u+{++++++++++++++++++++++++ƻư{sl hl7 h) h\)hTrt5 hTrt5hTrtOJQJh;OJQJh\ hDehrA hrA5hTrthrA5OJQJhi\ h\)hrAhrAh\)hrAOJQJhrAOJQJ hDeh) hOh\)h) OJQJh) OJQJ h\)h) h) h.yh) 5'e+f+j+,$1$7$8$H$Ifgd;l kd!$$Iflֈh^>+Pv0&-4 lapytrAj+p+s+++++~$IfgdDel $1$7$8$H$Ifgd4ul $Ifgd4ul $Ifgd) l $$Ifa$gd4ul $1$7$8$H$Ifgd;l +++,*kd"$$Iflֈh^>+Pv0&-4 lapytrA++++++ u$Ifgd l $Ifl $IfgdCl $@&Ifgd) l $Ifgd) l $$@&Ifa$l $1$7$8$H$IfgdTrtl +++ 78CDJPUadlmoprtyʿʰ{ʰtl`hCghl7 5OJQJh\)h\6 hTrth\hrAh\hu h\OJQJh\6OJQJh\)h\5OJQJ h\5h\)h\5 h\)h\h\OJQJh\)h\OJQJh;OJQJ h\)hTrthTrth\)hTrtOJQJhTrtOJQJU hTrt5hl7 h) 5%Ch. 16Tue 11/17CS22. Genetic Model systems-Yeast On line Ch. Yeast Ch. 5Ch. 7, p. 168-178Th 11/19CS23. Yeast- Discussion Problem Set 10 due (Yeast genetics) Article 10 for discussionTue 11/24AM24. Genetic Model systems- Drosophila Quiz 10: Yeast GeneticsOn line Ch. DrosophilaCh.5, p. 118-126Article 11 for discussion Th 11/26NO CLASS THANKSGIVING  Tue 12/1AM25. Genetic Model Systems- Drosophila Discussion Problem Set 11 due (Drosophila genetics) Article 12 for discussion Th 12/3AM26. Genetic Mosaics Quiz 11: Drosophila Genetics WB: Mosaics Article 13 for discussionTue 12/8CS27. Genetic Model Systems- Mouse On line Ch. MouseProblem Set 12 due (Mosaics)Th 12/10CS28. Genetic Model systems- Mouse Discussion Quiz 12: MosaicsProblem Set 13 due (Mouse genetics) Article 14 for discussion TBA Dec 16-23Final examLecture days have a QUIZ on the material from the week before and the reading of this day. Articles 1-14 in bold are to be discussed by the students. .$1$7$8$H$Ifl kd#$$Iflֈh^>+Pv0&-4 lapytC78JPbcw$Ifgd l $Ifl $IfgdCl $@&Ifgdl $@&Ifgdl $$@&Ifa$l $1$7$8$H$Ifl cdm.$1$7$8$H$Ifl kd$$$Iflֈh^>+Pv0&-4 lapytCmp$Ifgd[l $Ifl $Ifgdl $$@&Ifa$l  *+;<ʾʪymᐉaVh\)h4uOJQJh\)h;6OJQJhCgh;5OJQJh;h4u5h;h;5 h\)h4uh;OJQJh\)h;OJQJ h\)h\hl7 h\OJQJh\5OJQJhCgh\5OJQJh\)h\OJQJhh\5OJQJh;5OJQJhCghl7 5OJQJhl7 5OJQJ3$1$7$8$H$Ifgd;l kd%$$Iflֈh^>+Pv0&-4 lapyt.y +<VW$Ifl $Ifgd;l $Ifgdl $$@&Ifa$l <CDGUVXabxy{|~ #$%*,.A轶趲צ螶ߒ߆~׶גߒhCgh;5hh;5OJQJhCgh;5OJQJh\)h;6hTrth;5OJQJh; h\)h;h\)h;5 h\)h4uhCgh;OJQJh;OJQJh;5OJQJh\)h;OJQJh[h;5OJQJ1WXa8$1$7$8$H$Ifgd;l kd&$$Iflֈh^>+Pv0&-4 lap yt;abyz{}~~n$Ifl $IfgdCgl $Ifgdl $$Ifa$l $1$7$8$H$Ifgd4ul Ff($Ifgd;l $$@&Ifa$gd;l  $Ifgd.yl $Ifl  >%%$1$7$8$H$Ifgd4ul kd*$$Iflֈh^>+Pv0&-4 laytC %CDEQk$IfgdCl $Ifl $Ifgdl $$Ifa$l ABEQZ[jlpstxz &;<Cwghh;5OJQJmH sH h*h;5OJQJmH sH h;5OJQJmH sH h;5OJQJhCgh;5OJQJhTrth;5OJQJh\)h;mH sH h*h;5mH sH h;5mH sH h;OJQJh; h;5h.yh;5 h\)h;h\)h;OJQJ#klp3$1$7$8$H$Ifgd;l kd+$$Iflֈh^>+Pv0&-4 lapytCpux$Ifgd l $Ifl $Ifgd*l $$Ifa$l $1$7$8$H$Ifgd;l 3$1$7$8$H$Ifgd.yl kd,$$Iflֈh^>+Pv0&-4 lapytC<VW$Ifgd.yl $Ifl $Ifgd*l $Ifgdl $$Ifa$l $1$7$8$H$Ifgd.yl  CDEFGUVWXegqrv ȼvmh5OJQJh[5OJQJh\)hP75OJQJh\)hP7OJQJh\)h;5h\)h;5OJQJh\)h;OJQJ h\)h;h*h;5mH sH h;OJQJmH sH h;5OJQJmH sH hCgh;5OJQJmH sH h\)h;OJQJmH sH WX\.$1$7$8$H$Ifl kd-$$Iflֈh^>+Pv0&-4 lapytC\fgrstuv gdP7Ff/$Ifl $$Ifa$l $1$7$8$H$Ifl  2&P:pP7/ N!"#$% DyK yK Fmailto:alicia.melendez@qc.cuny.eduDyK yK Hmailto:Cathy.SavageDunn@qc.cuny.eduDyK yK Thttp://www.wormbook.org/toc_complete.htmlDyK yK http://highered.mcgraw-hill.com/classware/infoCenter.do?isbn=0072848464DyK yK http://catalogs.mhhe.com/mhhe/viewProductDetails.do?isbn=0073227382DyK yK *http://www.amazon.com/Genetics-Genes-Genomes-Leland-Hartwell/dp/0073227382/ref=pd_bbs_sr_1/002-5008744-7778403?ie=UTF8&s=books&qid=1184208692&sr=1-1[DyK yK http://www.qc.cuny.edu/about/administration/Provost/Policies/Documents/Academic%20Integrity%20Memo%20Fall%202014.pdf$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4aytC^$$If!vh#vP#vv#v#v#v#v:V l <0&-5P5v5555/ 4ap<ytC kd $$Iflֈh^>+Pv <0&-4 lap<ytCP$$If!vh#vP#vv#v#v#v#v:V l <0&-5P5v55554ap<ytC kdy$$Iflֈh^>+Pv <0&-4 lap<ytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4ap<ytC^$$If!vh#vP#vv#v#v#v#v:V l <0&-5P5v5555/ 4ap<ytC kd$$Iflֈh^>+Pv <0&-4 lap<ytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554ap<ytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554ap<ytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554ap<ytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4apytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4ap<ytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4apytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554apytrA$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4apytrA$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4apytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4apytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ / 4apyt.y$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4ap yt;^$$If!vh#vP#vv#v#v#v#v:V l <0&-5P5v5555/ 4ap<yt; kd'$$Iflֈh^>+Pv <0&-4 lap<yt;$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4aytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v55554apytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4apytC$$If!vh#vP#vv#v#v#v#v:V l0&-5P5v5555/ 4apytCP$$If!vh#vP#vv#v#v#v#v:V l <0&-5P5v55554ap<ytC kd.$$Iflֈh^>+Pv <0&-4 lap<ytC666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~_HmH nH sH tH <`< NormalCJ_HmH sH tH 8@8  Heading 1$@&5>@>  Heading 2$$@&a$58@8  Heading 3$@&6DA D Default Paragraph FontZi@Z  Table Normal :V 4 l4a _H(k (No List 6U`6 Hyperlink >*B*phH@H  Balloon TextCJOJQJ^JaJ@V`@ FollowedHyperlink>*B* R^@"R [0 Normal (Web)dd[$\$CJOJPJQJPK!pO[Content_Types].xmlj0Eжr(΢]yl#!MB;.n̨̽\A1&ҫ QWKvUbOX#&1`RT9<l#$>r `С-;c=1g~'}xPiB$IO1Êk9IcLHY<;*v7'aE\h>=^,*8q;^*4?Wq{nԉogAߤ>8f2*<")QHxK |]Zz)ӁMSm@\&>!7;wP3[EBU`1OC5VD Xa?p S4[NS28;Y[꫙,T1|n;+/ʕj\\,E:! t4.T̡ e1 }; [z^pl@ok0e g@GGHPXNT,مde|*YdT\Y䀰+(T7$ow2缂#G֛ʥ?q NK-/M,WgxFV/FQⷶO&ecx\QLW@H!+{[|{!KAi `cm2iU|Y+ ި [[vxrNE3pmR =Y04,!&0+WC܃@oOS2'Sٮ05$ɤ]pm3Ft GɄ-!y"ӉV . `עv,O.%вKasSƭvMz`3{9+e@eՔLy7W_XtlPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-!pO[Content_Types].xmlPK-!֧6 -_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!!Z!theme/theme/theme1.xmlPK-! ѐ'( theme/theme/_rels/themeManager.xml.relsPK]# #  BMYOF!#5$$%%&&^''()K*++<AC  !"#$&'()*+,38<?CHKPUY_dmpv{ Z#c#####f$o$$$&%[%\%%&%&]&^&&&6'@'''''k(u())))))J*T****+e+j+++ cmWa kpW\ %-./01245679:;=>@ABDEFGIJLMNOQRSTVWXZ[\]^`abcijklnoqrstuwxyz|}TC|4KWuzc#XXXXXXX8  @p (   M*  F|| "Group 8"?PK![Content_Types].xmlAN0EH%] tA% T0'dly'-XӸ\AL:}^HUcd`p* VCLj__'2?첋Y%{VA!< psșk[1ool>)&a8}/PK!#j _rels/.relsj0 }qN/k؊c[F2e~"Kl`0;1 (6{PF783.#c(Y ̵W͘tT0Dlm#]ڀzgͿ0n @]nStLBS%M=lݑm7rf9`5Y4Բ~G>~WoPK!B[drs/e2oDoc.xmlUm6 ^`A9+ t[f?@̖\IsGRvΗ%-!E>; ;IckV< 9*y}-8N\4Z{Cߥ2֕nriQ6 Y%[aot' mZ`k 7maxљn?(tYqiyg ҈8'_jh w6EQgbh*'R}]hjxaٯO9.LrDn2'}> ,? Z+C8:Mܜ Ӣ )ϗȳc|[Y(*H# D/ O>wI0X}a?6?W$Tl#;#%/[zBIkdNHo1R=6D{!N 8 a7hog,díAFۇgz0:BEQcr(uvVlX1m'jłr: !~G|%9@?$3$I'"Cd'$rWN^j,NPy1@TuZwuPPqcuS(D4֔ucI`p{^A/R9ȷډkpPXZbHfI|%a~6zТ$< э 9JFo*WukD22):)r3\WJ?9arFr|PpQ8Mr7acT"TVq(p\ae"J5gQ yYB stOZ/PK!鏜 drs/downrev.xmlLAO@&͘xVEB1L چn]t9FY j d6Β yXf7)&'P >A Um"+2觮%˷ ])7h& ֖?TҺ= oNe{(n\4?:dζa&lJD~gY*~PK-![Content_Types].xmlPK-!#j ,_rels/.relsPK-!B[,drs/e2oDoc.xmlPK-!鏜 drs/downrev.xmlPK  c @0e0e@AB$CDEF QRUVX?$@$Freeform 9#"ÏPK!2<>[Content_Types].xmlAN0EH%,BM #{X$ccB{{&m TҞy?٫vՌ}Z_VH68O}6ōV;dnV]DVBz9v I&]Hd9DУkce\%C7;Dp{KU!["jK8 p&î8By/ O4;Tϐ#La\bDR7q[,į W pov+ fCPK!]  _rels/.relsj1 @h_B֐BWaLΖ5yB/dˠA 0xM e`J FG2p%}iRdITD10Z)4(I9`mtB{ƁmtπnTg 險,ܗr>j1W*@ŀӚZ7O#KOiPK!3/A9drs/shapexml.xmlQ(K-*ϳU23PRHKOKU qӵPR(.IKIKUL-VPK!Ykdrs/downrev.xmlDOۊ0}0/ "],C2eIib[ 6sզhcIX;Spv/AltL aV75א>EyU*9YWGj!:6RΒd!-rh>}YgkWKu(5t u_>8_rPK-!2<>[Content_Types].xmlPK-!]  ,_rels/.relsPK-!3/A9(drs/shapexml.xmlPK-!Ykdrs/downrev.xmlPKM*  M*  >|| bGroup 8?*?*ATT"?PK![Content_Types].xmlAN0EH%] tA% T0'dly'-XӸ\AL:}^HUcd`p* VCLj__'2?첋Y%{VA!< psșk[1ool>)&a8}/PK!#j _rels/.relsj0 }qN/k؊c[F2e~"Kl`0;1 (6{PF783.#c(Y ̵W͘tT0Dlm#]ڀzgͿ0n @]nStLBS%M=lݑm7rf9`5Y4Բ~G>~WoPK!B[drs/e2oDoc.xmlUm6 ^`A9+ t[f?@̖\IsGRvΗ%-!E>; ;IckV< 9*y}-8N\4Z{Cߥ2֕nriQ6 Y%[aot' mZ`k 7maxљn?(tYqiyg ҈8'_jh w6EQgbh*'R}]hjxaٯO9.LrDn2'}> ,? Z+C8:Mܜ Ӣ )ϗȳc|[Y(*H# D/ O>wI0X}a?6?W$Tl#;#%/[zBIkdNHo1R=6D{!N 8 a7hog,díAFۇgz0:BEQcr(uvVlX1m'jłr: !~G|%9@?$3$I'"Cd'$rWN^j,NPy1@TuZwuPPqcuS(D4֔ucI`p{^A/R9ȷډkpPXZbHfI|%a~6zТ$< э 9JFo*WukD22):)r3\WJ?9arFr|PpQ8Mr7acT"TVq(p\ae"J5gQ yYB stOZ/PK!鏜 drs/downrev.xmlLAO@&͘xVEB1L چn]t9FY j d6Β yXf7)&'P >A Um"+2觮%˷ ])7h& ֖?TҺ= oNe{(n\4?:dζa&lJD~gY*~PK-![Content_Types].xmlPK-!#j ,_rels/.relsPK-!B[,drs/e2oDoc.xmlPK-!鏜 drs/downrev.xmlPK   c @0e0e@AB$CDEF QRUVX?$@$Freeform 9#"ÏPK!2<>[Content_Types].xmlAN0EH%,BM #{X$ccB{{&m TҞy?٫vՌ}Z_VH68O}6ōV;dnV]DVBz9v I&]Hd9DУkce\%C7;Dp{KU!["jK8 p&î8By/ O4;Tϐ#La\bDR7q[,į W pov+ fCPK!]  _rels/.relsj1 @h_B֐BWaLΖ5yB/dˠA 0xM e`J FG2p%}iRdITD10Z)4(I9`mtB{ƁmtπnTg 險,ܗr>j1W*@ŀӚZ7O#KOiPK!3/A9drs/shapexml.xmlQ(K-*ϳU23PRHKOKU qӵPR(.IKIKUL-VPK!Ykdrs/downrev.xmlDOۊ0}0/ "],C2eIib[ 6sզhcIX;Spv/AltL aV75א>EyU*9YWGj!:6RΒd!-rh>}YgkWKu(5t u_>8_rPK-!2<>[Content_Types].xmlPK-!]  ,_rels/.relsPK-!3/A9(drs/shapexml.xmlPK-!Ykdrs/downrev.xmlPKM*B S  ?#'K-Nr@!&E-@ _Hlt301600962 _Hlt126233217B#@@#  7 : ; C 2?Z\JL=?JPU`ekmt!#35uw&*MOqu {!}!#"*"7">"A"C"""""#G###::::>y'-t6h^`OJQJo(hHh^`OJ QJ ^Jo(hHohpp^p`OJQJo(hHh@ @ ^@ `OJQJo(hHh^`OJ QJ ^Jo(hHoh^`OJQJo(hHh^`OJQJo(hHh^`OJ QJ ^Jo(hHohPP^P`OJQJo(hH>y'-         0/) l7 ,P;FP)_R_[i\5d(DhTrt4uA|ic'R\u )OP7s;rA.yzzP;=Ck\k1_^De*  \)Cg;[ xY;^=\##@|XEEEyyv#@$@ D@@Unknown G*Ax Times New Roman5Symbol3 *Cx Arial3Times;[xPHelveticaK Times-RomanTimes5 *[`)Tahoma3Nj-3 fg;Wingdings? *Cx Courier NewA$BCambria Math"Ah8g8g3KL6@L6@!2tp#p#' 3qHP $Pt2! xx ,Molecular Genetics: Biology 700Harold MichelsAlicia Melndez  Oh+'0 ( L X d p|' Molecular Genetics: Biology 700Harold Michels Normal.dotmAlicia Melndez5Microsoft Macintosh Word@`4<@2@`v@l`L6 ՜.+,D՜.+,L hp|  ' @p#  Molecular Genetics: Biology 700 Title 8@ _PID_HLINKS'At*Emhttp://www.qc.cuny.edu/about/administration/Provost/Policies/Documents/Academic Integrity Memo Fall 2014.pdf;Qhttp://www.amazon.com/Genetics-Genes-Genomes-Leland-Hartwell/dp/0073227382/ref=pd_bbs_sr_1/002-5008744-7778403?ie=UTF8&s=books&qid=1184208692&sr=1-1Q- Dhttp://catalogs.mhhe.com/mhhe/viewProductDetails.do?isbn=0073227382& Hhttp://highered.mcgraw-hill.com/classware/infoCenter.do?isbn=0072848464iz*http://www.wormbook.org/toc_complete.htmlP$mailto:Cathy.SavageDunn@qc.cuny.eduJp#mailto:alicia.melendez@qc.cuny.edu  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry FOJData 11TableEWordDocument4SummaryInformation(DocumentSummaryInformation8CompObj` F Microsoft Word 97-2004 DocumentNB6WWord.Document.8