ࡱ> rtq_ SbjbjzXzX .|2@\2@\s@%  8t4-D"ff @-B-B-B-B-B-B-$/Y2f-"#U | "#"#f-f[{-P&P&P&"#lf@-P&"#@-P&P&: ,,6,x $8, ,--0-B,R2%2,2, Z+!@P&k!4! f-f-%v -"#"#"#"#2 > : PRESCRIBER Features: Talking to patients Volume No: 15 Issue No: 3 5 February 2004 Talking to patients and families about first-time psychosis By Dr David Shiers MRCP Your daughter has schizophrenia she is not a schizophrenic. I still clearly remember this advice from my daughters specialist 10 years ago. Her psychosis emerged at 16, reflecting its peak onset in teenagers and young adults. Any illness that sets you apart from your peers causes difficulties at this age, heightened by myths and negative stereotypes about mental illness. Even as an experienced GP I felt unprepared for my new caring role, and had not anticipated the overwhelming sense of disempowerment. People experiencing a psychosis for the first time may not understand what is happening to them. Often the diagnosis emerges after months of distress and concern. Many are diagnosed following a crisis, with as many as 80 per cent being hospitalised and 50 per cent legally detained, often with police involvement. Not only will patients and families be dealing with the impact of the illness but they may also be suffering the trauma of the engagement with specialist services. Families and friends will have needs of their own. The WHO recently estimated that the burden to family and community from psychosis is only exceeded by dementia and quadriplegia. Yet the quality of support varies, and many feel marginalised by services, seemingly unaware of their huge contribution as informal care-givers. Responding positively to the needs of families and close friends will improve their ability to care and is a cornerstone of high-quality practice. GPs should familiarise themselves with the emerging concept of recovery to help understand why the outcomes that these young people and their families will most value are about improving the subjective quality of their lives and ability to function socially, rather than merely obtaining symptom relief.  SHAPE \* MERGEFORMAT  The need for clear information GPs and other healthcare professionals can provide time and sensitive exploration in a nonstigmatising primary care setting to questions like: What is psychosis? Advise the patient that it is a condition that affects the mind. It leads to a changed sense of reality, changes in mood and thinking, and to unusual ideas, which can make it hard to understand how that person feels. Why did I get psychosis? What causes it? It can happen to anyone. Some families have more than one affected member, pointing to genetic factors. Sometimes a difficult birth may increase the risk. But for the main part we still do not know and need further research to understand this. What are the typical symptoms? You may be asked to describe symptoms, eg confused thinking, delusions, hallucinations, upset feelings and unexpected behaviours. Is psychosis the same thing as schizophrenia or bipolar disease? Patients may hear several diagnostic terms: schizophrenia, organic psychosis, schizoaffective, drug-induced, bipolar, psychotic depression. Diagnosing the exact type of psychosis is difficult in the early stages because many of the factors that determine the label remain unclear. A thorough examination to rule out known medical causes is necessary to make the diagnosis as clear as possible Will I get better? Like most illnesses psychosis can be treated and most people recover. About a quarter never experience further illness. Over half get better but will have further episodes and about 1 in 10 continue to experience persistent difficulties. What treatments are available? What about medication? My general approach is to point out that medicines are a tool that enable other psychological and social interventions to work. It is not an either-or but a both-and. For detailed considerations see below. What is the Care Programme Approach? It is easy to forget how complex the health system can appear. Explanations are needed of how care is planned (care programme approach CPA), how it enables holistic formulation of treatment plans, what a care co-ordinator is, how to access help if things go wrong, the Mental Health Act, advance directives and advocacy to help patients make decisions in difficult circumstances. How long will it take to respond to treatment? Most patients feel a lot better within a few weeks and get back to normal within three to six months. Most doctors advise continuing treatment for at least 12 months, even if fully recovered. Can I prevent it coming back? Are there early-warning signs to watch out for? Table 1 lists the commonest symptoms observed before a relapse. Although not specific to psychosis in themselves, when these symptoms appear in a pattern of increasing intensity they give an important opportunity to intervene early in a relapse. Most people can be taught to recognise their own characteristic pattern of symptoms, known as the relapse signature. Patients and their families can be taught how to recognise and report this as part of their own relapse drill. They can then seek prompt help to nip it in the bud, providing a highly effective way to prevent or minimise relapse. Such management has been shown to drastically reduce the severity and length of relapse and minimise hospitalisation.  SHAPE \* MERGEFORMAT  Can I drive? If the mental state impairs concentration or judgment, then the patient should be advised not to drive and to inform the DVLA.1 In all cases where the patient is a heavy goods vehicle or passenger-carrying vehicle driver, the DVLA should be informed. Why my son, daughter or spouse? Is it because I am a bad parent? This challenging illness is no-ones fault. It is invariably painful to families and close friends and they have their own legitimate needs for help. They should expect feelings of sadness and a sense of loss of the person they knew. Trying to access services may have been difficult and provoked anger and frustration. These feelings should be responded to directly and with empathy. What can families do to help? Families can offer a great deal, but they will care more effectively if they learn to look after themselves. The first step is to come to terms with what has happened. Coping strategies can be taught through psychoeducation. Where can I get more advice? The Resources box lists some sources of patient/carer information. The EPPIC website contains clear information sheets, which I would unhesitatingly recommend to any new patients and their families. Early intervention treatment approaches The seeds of longer-term difficulties can be sown in this early phase and it is known that this stage demands quite different treatment approaches from those given to a person with more long-standing illness. The Initiative to Reduce the Impact of Schizophrenia (IRIS) guidance2 summarises the evidence base for what constitutes early intervention; not only should modern drug therapies be offered, but also psychosocial interventions and family interventions. The National Institute for Clinical Excellence (NICE) schizophrenia guidance for patients at all stages of schizophrenia balances modern pharmacological approaches with psychological and social interventions.3 Issues around treatment Ask yourself how you would feel as a young person about taking medication, attending outpatients or accepting admission. Engagement and rapport building should not hinge on a patients acceptance of treatment. Treatment refusal should not lead to reduced contact or discharge indeed, quite the reverse. Medicines Educating patients and families allows them to become proficient at understanding and using their medication and exercising their right to informed choice. Information on short-term benzodiazepine and antidepressant use, often used to reduce some symptoms of psychosis, is straightforward, but prescribing issues around use of the antipsychotic medicines may need special attention. Efficacy Sixty per cent of patients respond by 12 weeks, another 25 per cent more slowly, and 15 per cent will not respond and this treatment-resistant group may respond to clozapine (Clozaril). Risk of relapse requiring hospitalisation is reduced by two-thirds in the two years after diagnosis if antipsychotic medication is taken for at least 12 months. How do they work? The first antipsychotic, chlorpromazine (Largactil), was originally developed as an antihistamine in the 1950s and observed to have a tranquillising effect. This discovery led to the development of a whole class of drugs used to alleviate distressing delusions and hallucinations. The first ones to appear are now referred to as the typical antipsychotics because of their shared properties. We have some understanding of how they work: they block various chemical receptor sites in the brain, particularly those receptors relying on dopamine and serotonin for transmission. Dopamine is an important chemical in parts of the brain that control muscle tone and movement, and can cause disabling side-effects quite similar to Parkinsons disease. Certain movement disorders (tardive dyskinesia) can persist even if the medicine is stopped. All antipsychotics cause side-effects, but there is considerable class difference A number of medicines have been developed since chlorpromazine and the typical antipsychotics. Although equally effective at alleviating symptoms, the older typical medicines must now be judged against newer atypical ones. The atypical medicines offer the important advantage of rarely causing movement disorders. However, they can cause side-effects of their own, sometimes affecting other parts of the brain and body leading to weight gain, a tendency to diabetes, sexual dysfunction, and excess salivation (see Table 2). Each drug is different and the specific side-effects should be discussed in each situation. NICE guidance recommends the newer atypicals as first choice in first-episode psychosis. There remains one important drug that fits less easily into this classification called clozapine. This offers therapeutic properties for those whose symptoms are treatment resistant when other treatments are failing. However a risk of blood dyscrasias requires efficient monitoring systems. In conclusion, all these drugs, while effective, can cause side-effects and it is vital that patients and families become experts in using their medicines.  SHAPE \* MERGEFORMAT  How are they taken? Most atypical medications are taken by mouth as tablets, and risperidone is now available in an orodispersible formulation (Risperdal Quicklet), which patients may find preferable. Risperdal is also available as a long-acting injection. Many of the older typical antipsychotics are available as long-acting injections, given intramuscularly every two to four weeks. Patients usually prefer medication taken by mouth, but occasionally a young person actually prefers an injectable preparation if their work or social life means that constantly remembering medication is a problem. Psychosocial interventions Patients may have engaged services after a long period of psychotic symptoms, resulting in unstable living and financial circumstances. Patients and families should be helped to recognise their importance in avoiding relapse and directed to appropriate specialised help: legal aid, social workers, the Citizens Advice Bureau, etc. Maintaining positive social roles and goals in terms of work or education is highly valued and improves self-esteem in young people. Thus long interruptions of these activities can have a profoundly negative impact on the psychosis and increase the likelihood of long-term difficulty. Valued and, where possible, paid, occupation provides a major source of self-esteem, social contact and money. Prolonged unemployment and lack of skills are known impediments to employment, particularly in young people. Access to the disability living allowance (DLA), while providing extra income, is a major disincentive to work and should be avoided in this early phase of psychosis.4 Family as part of the treatment approach Thinking of the family as part of the treatment team sets the stage for reconciling the apparent dilemma of patient confidentiality with the familys need to know. Developing an alliance with the family often holds the key to engaging the patient: it helps formulate more effective treatment plans by accessing valuable information about their relatives problems, and they can alert services promptly when things go wrong. Suicide risk One in ten people developing psychosis will ultimately commit suicide, two-thirds of these within the first five years. Explain these risks and the importance of detecting and acting on factors such as depression and particularly hopelessness.  SHAPE \* MERGEFORMAT  Conclusion Psychosis usually develops in young people, putting in jeopardy key aspirations such as work, self-determination and relationships. When talking to patients about psychosis, discussions should reflect these concerns and convey a sense of hope and encouragement to regain and further develop former skills, interests and life goals. In thinking about therapeutic interventions, remember that symptom control by itself is not sufficient but should be thought of in the context of helping these young people achieve subjective quality of life and optimal daily functioning. Use of the modern atypical medicines in appropriate dosage and for a minimum of 12 months forms a cornerstone of modern treatment, in conjunction with psycho-educational approaches both to the patient and families. Families should be supported to enable them to care more effectively. People are not diagnoses or case histories. Be a person-friendly service, as the stigma of mental illness comes not just from the general public, but can be an effect of the way health professionals work, think and talk. References IRIS. Early intervention in psychosis: clinical guidelines.  HYPERLINK "http://www.iris-initiative.org.uk" www.iris-initiative.org.uk Schizophrenia: core interventions in the treatment and management of schizophrenia in primary and secondary care. National Institute for Clinical Excellence, 2002.  HYPERLINK "http://www.nice.org.uk/docref.asp?d=42460" www.nice.org.uk/docref.asp?d=42460 Spencer B, Birchwood M, McGovern D. Management of first episode psychosis. Advan Psychiatr Treat 2001;7:133-42. At a glance guide to medical aspects of fitness to drive. Swansea: DVLA, 1998.  HYPERLINK "http://www.dvla.gov.uk/at_a_glance/ch4_psychiatric.htm" www.dvla.gov.uk/at_a_glance/ch4_psychiatric.htm Dr Shiers is a GP in Leek, Staffordshire, and is Joint Lead for the National Early Intervention in Psychosis Programme of the National Institute for Mental Health in England and Rethink POSTSCRIPT TO TALKING TO PATIENTS AND FAMILIES ABOUT FIRST TIME PSYCHOSIS Since writing this article some important developments have increased our understanding of side effects and tolerability of antipsychotic medicines. The development of a so-called second generation of atypical drugs was built on the belief that these newer medicines would cause fewer unwanted neurological side-effects typical of the first generation drugs. However initial optimism appears to have been misplaced. Whilst these newer drugs appear equally effective, and even though neurological side-effects may be less prominent, attention is shifting towards other potentially serious adverse effects on weight, glucose metabolism and blood lipids [1]. Thus it seems that all antipsychotic drugs, and clozapine and olanzapine in particular, can cause or worsen cardiovascular risks. This is a real concern given the risk of premature deaths these young people may face as they get older.[2] In summary describing these antipsychotic drugs as typical or atypical (sometimes called second generation) appears unhelpful and practitioners should offer and tailor treatment to maximise benefits and minimise side-effects, including metabolic abnormalities, in individual patients. David Shiers 4th February 2009 References [1] Newcomer JW: (2005) Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs; 19(suppl 1):1-93. [2] Parks J, Svendsen D, Singer P, Forti M.E. (2006) Morbidity and Mortality in People with Serious Mental Illness. National Association of State Mental Health Programme Directors, 13th technical     PAGE  PAGE 5 Recovery paradigm: Modern psychiatry is starting to embrace a radical shift away from treatment models derived from Kraepelins original description of dementia praecox as a single disease entity (schizophrenia) with a universally poor outcome. That traditional wisdom (which I was taught) increasingly is confounded by evidence that people with the severest of illnesses can make partial or complete recovery. Now, we better understand how interactions with environment, family and friends, life events, and indeed life choices made by patients and families, can influence the course of psychosis. From this derives new treatment options; a justified basis for therapeutic optimism in early intervention; psycho-education of patients and families; social interventions to support access to education; employment and housing. Table 1: Some early signs of relapse Tense, afraid, anxious Quiet withdrawn Depressed, low Irritable, quick-tempered Violent, aggressive Restlessness Hearing voices Poor appetite, weight loss Forgetfulness Neglect of appearance Table 2: Side effects of anti-psychotic drugs Young patients in particular may find some of these embarrassing and difficult to raise in consultation Movement disorders shaking and rhythmic movements of the tongue and face; tardive dyskinesia is irreversible even after stopping treatment Appetite stimulation leading to weight gain Exacerbation of epilepsy Breast enlargement and milk production Sexual effects: loss of libido and erectile dysfunction Blood disorders; patients may have to attend surgery for blood monitoring Hypotension may lead to dizziness Increased risk of type 2 diabetes Constipation, urinary retention Salivation (especially with clozapine) Resources EPPIC Early Psychosis Prevention and Intervention Centre  HYPERLINK "http://www.eppic.org.uk/resources/index.html" www.eppic.org.au Rethink  HYPERLINK "mailto:advice@rethink.org" National Advice Service provides information and support for people suffering from schizophrenia, their families and carers: Tel: 020 8974 6814: email  HYPERLINK "mailto:advice@rethink.org" advice@rethink.org: website  HYPERLINK "http://www.rethink.org/information/nas.htm" http://www.rethink.org/information/nas.htm MIND infoline telephone information line on mental health issues. Tel 08457 660163; email  HYPERLINK "mailto:info@mind.org.uk" info@mind.org.uk; website  HYPERLINK "http://www.mind.org.uk" www.mind.org.uk Manic-depression fellowship: a user-led organisation providing support for people with manic depression through self-help groups, information, publications, legal advice tel 020 7793 2639: email  HYPERLINK "mailto:mdf@mdf.org.uk" mdf@mdf.org.uk: website  HYPERLINK "http://www.mdf.org.uk" www.mdf.org.uk  *XYZҼyfP=P*P%h 5B*CJOJQJ\aJph%hBO5B*CJOJQJ\aJph+hh45B*CJOJQJ\aJph%hh4B*CJOJQJaJph/hh45B*CJOJQJ\^JaJph/hh5B*CJOJQJ\^JaJph%hhB*CJOJQJaJph+hh6B*CJOJQJ]aJph)h5B*CJOJQJ\^JaJph/hh5B*CJ(OJQJ\^JaJ(ph  *YZ jjXvp!q!gd4gdijjٸ~o^I7#h0JB*CJOJQJaJph)hh40JB*CJOJQJaJph!hh40JB*OJQJphhhB*OJQJph&jhhB*OJQJUph3jhB*CJOJQJUaJmHnHphuhB*OJQJph jhB*OJQJUphhB*CJOJQJaJph%hh4B*CJOJQJaJph%hh4B*CJOJQJaJphj|XvXYHשv^.jhh0B*CJOJQJUaJph?jhh|6B*CJOJQJU]aJmHnHphu%hh|B*CJOJQJaJph.jhh|B*CJOJQJUaJph+hh46B*CJOJQJ]aJph%hh4B*CJOJQJaJph)hh40JB*CJOJQJaJphHI o!p!q!!!!""<$=$>$U$%%''z((+',0000سqYY.jhhB*CJOJQJUaJphhhB*OJQJphhh4B*OJQJph!hh40JB*OJQJph%hhB*CJOJQJaJphh4B*CJOJQJaJph)hh40JB*CJOJQJaJph%hh4B*CJOJQJaJph(h>:h4B*CJH*OJQJaJphq!!n">$%'z(*+j-.0001.3456789 :':;o<G==l>w>gd0gd4000000.3H3475767^79999 9 :ʲwwbwwLw:h4B*CJH*OJQJaJph%hh4B*CJOJQJaJph)hh40JB*CJOJQJaJph%hhB*CJOJQJaJph.jhhB*CJOJQJUaJph.j hh0B*CJOJQJUaJph9jhhB*CJOJQJUaJmHnHphu : : :":#:$:%:&:':1:2: = =k>l>v>ڭڂqbO?OqhoB*CJOJQJaJph%hh4B*CJOJQJaJphhh4B*OJQJph!hh40JB*OJQJph%hhB*CJOJQJaJph.jh"`hoB*CJOJQJUaJph9jh"`6B*CJOJQJU]aJmHnHphuh"`B*CJOJQJaJph(jh"`B*CJOJQJUaJphh4B*CJOJQJaJphv>w>>>>>>>??????@@q@@@AA6A7A8AiAnAAԼԼԼԼԘoZEZ)h0hFe0JB*CJOJQJaJph)h0h40JB*CJOJQJaJph h0h(@0JCJOJQJaJ.jh0h(@B*CJOJQJUaJph%h0h(@B*CJOJQJaJph h0h40JCJOJQJaJ.jh0h4B*CJOJQJUaJph%h0h4B*CJOJQJaJph/h0h00J5B*CJOJQJ\aJphw>?@r@8AAA>B?BEEFFFFGGGGsHuHvHxHyH{HgdCX&gdCX&$a$gdCX&gdCX&gd(@ & Fgd(@ & Fgd0AAAAAA>B?B CCCCCCD$DVDDñvavavMv?.? h]hCX&CJOJQJ^JaJhCX&CJOJQJ^JaJ&h]hCX&CJOJQJ\]^JaJ)hYLUhCX&6CJOJQJ\]^JaJ hCX&CJOJQJ\]^JaJ)h]hCX&5CJOJQJ\]^JaJ)h`\hCX&5CJOJQJ\]^JaJ#hCX&0JB*CJOJQJaJph#hRJ0JB*CJOJQJaJph)h0h40JB*CJOJQJaJph)h0hFe0JB*CJOJQJaJphDDDDDDE E5E^EtEEEEEEEEEEEFF FF0F2F]FgFFFFFFFGGq\)hCX&0J5CJOJQJ^JaJmH sH &hhCX&5CJH*OJQJ^JaJ#hhCX&5CJOJQJ^JaJ)h`\hCX&5CJOJQJ\]^JaJ&h`\hCX&56CJOJQJ^JaJhCX&5CJOJQJ^JaJ#h`\hCX&5CJOJQJ^JaJhCX&CJOJQJ^JaJ h]hCX&CJOJQJ^JaJ$GGGGG"G#G'G)GGGGGGGGGGGGGGG#HrHsHtHvHwHyHzH|H}HHHHHHֵֵֵֵֵֵ֟xtxtxtxtjdjd hV0JjhV0JUh(Ujh(UUh0hCX&CJaJ'h]hCX&0J5CJOJQJ^JaJ*h]hCX&0J6CJOJQJ]^JaJ$h]hCX&0JCJOJQJ^JaJhCX&CJOJQJ^JaJ h]hCX&CJOJQJ^JaJ/hhCX&0J5CJOJQJ^JaJmH sH %{H|H~HHHHHHHHHKKKKLL,L;LULiLvLLLLLL$a$gd|gd &`#$gdVHHHHHHHHHHHiKjKKKLLLLZM[McOdOϽ}yiWiF? hh hhCJOJQJ^JaJ"hh56CJOJQJaJhh5CJOJQJaJh| hh|CJOJQJ^JaJhh|5CJOJQJaJhh+WCJOJQJaJhhCJOJQJaJ"hh56CJOJQJaJh(UjhV0JU*h80JmHnHu* hV0JjhV0JUhVLL[MMN-NTNNNNO6666666666666666666666666666666666666666666666666hH66666666666666666666666666666666666666666666666666666666666666666p62&6FVfv2(&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@_HmH nH sH tH @`@ NormalCJ_HaJmH sH tH @@@ CX& Heading 1$@& CJaJ,tH DA`D Default Paragraph FontRiR  Table Normal4 l4a (k (No List <U@< 4 Hyperlink7>*S*Y(phB^@B 4 Normal (Web)dd[$\$*W@* 4Strong5\.X@!. 4Emphasis6]FV1F |FollowedHyperlink >*B* phB@BB  Footnote Text CJaJtH 4 @R4 VFooter  9r .)@a. 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[ @Verdana5. .[`)Tahoma;Wingdings?= *Cx Courier NewACambria Math"1h;';'}F 6 t 6 t!4S@S@ 2qHP ?FW2!xx Features : Talking to patientsDavid Mary Bryant  Oh+'0  , L X d p| Features : Talking to patientsDavidNormal Mary Bryant2Microsoft Office Word@F#@,^%@l @l  6՜.+,D՜.+,P  hp  irist S@ Features : Talking to patients Titlel 8@ _PID_HLINKSA$BZb7http://www.dvla.gov.uk/at_a_glance/ch4_psychiatric.htm*http://www.nice.org.uk/docref.asp?d=42460## #http://www.iris-initiative.org.uk/-rhttp://www.mdf.org.uk/xmailto:mdf@mdf.org.uk 1http://www.mind.org.uk/:] mailto:info@mind.org.uk#$ +http://www.rethink.org/information/nas.htmIimailto:advice@rethink.orgIimailto:advice@rethink.orgD-http://www.eppic.org.uk/resources/index.html  !"#$%&'()*+,-./0123456789:;<=>@ABCDEFHIJKLMNOPQRSTUVWXYZ[\]^_`bcdefghjklmnopsRoot Entry F}x uData ?1TableG2WordDocument.|SummaryInformation(aDocumentSummaryInformation8iCompObjr  F Microsoft Word 97-2003 Document MSWordDocWord.Document.89q