ࡱ>  "{ bjbjzz &J)J)))))))8)+)j-4"444T8;;h$Ŀl)9)J<28"T8J<J<)J)J)44JbVEVEVEJ<J)84)4VEJ<VEVE+)40œ$?Lx070@l0|0)lJ<J<VEJ<J<J<J<J<))VEJ<J<J<J<J<J<J<0J<J<J<J<J<J<J<J<J< (:  February 2013 Teacher's Guide for Brand-Name vs. Generic Drugs: Whats the Difference? Table of Contents  TOC \o "1-3" \h \z \u  HYPERLINK \l "_Toc348351354" About the Guide  PAGEREF _Toc348351354 \h 2  HYPERLINK \l "_Toc348351355" Student Questions  PAGEREF _Toc348351355 \h 3  HYPERLINK \l "_Toc348351356" Answers to Student Questions  PAGEREF _Toc348351356 \h 4  HYPERLINK \l "_Toc348351357" Anticipation Guide  PAGEREF _Toc348351357 \h 5  HYPERLINK \l "_Toc348351358" Reading Strategies  PAGEREF _Toc348351358 \h 6  HYPERLINK \l "_Toc348351359" Background Information  PAGEREF _Toc348351359 \h 8  HYPERLINK \l "_Toc348351360" Connections to Chemistry Concepts  PAGEREF _Toc348351360 \h 18  HYPERLINK \l "_Toc348351361" Possible Student Misconceptions  PAGEREF _Toc348351361 \h 19  HYPERLINK \l "_Toc348351362" Anticipating Student Questions  PAGEREF _Toc348351362 \h 19  HYPERLINK \l "_Toc348351363" In-class Activities  PAGEREF _Toc348351363 \h 19  HYPERLINK \l "_Toc348351364" Out-of-class Activities and Projects  PAGEREF _Toc348351364 \h 20  HYPERLINK \l "_Toc348351365" References  PAGEREF _Toc348351365 \h 21  HYPERLINK \l "_Toc348351366" Web sites for Additional Information  PAGEREF _Toc348351366 \h 22  HYPERLINK \l "_Toc348351367" More Web sites on Teacher Information and Lesson Plans  PAGEREF _Toc348351367 \h 23  About the Guide Teachers Guide editors William Bleam, Donald McKinney, Ronald Tempest, and Erica K. Jacobsen created the Teachers Guide article material. E-mail:  HYPERLINK "mailto:bbleam@verizon.net" bbleam@verizon.net Susan Cooper prepared the anticipation and reading guides. Patrice Pages, ChemMatters editor, coordinated production and prepared the Microsoft Word and PDF versions of the Teachers Guide. E-mail:  HYPERLINK "mailto:chemmatters@acs.org" chemmatters@acs.org Articles from past issues of ChemMatters can be accessed from a CD that is available from the American Chemical Society for $30. The CD contains all ChemMatters issues from February 1983 to April 2008. The ChemMatters CD includes an Index that covers all issues from February 1983 to April 2008. The ChemMatters CD can be purchased by calling 1-800-227-5558. Purchase information can be found online at  HYPERLINK "http://chemistry.org/chemmatters/cd3.html" www.acs.org/chemmatters. Student Questions By law, what must be the same for a brand-name drug and its generic equivalent? What can be different? What is the role of the active ingredients in a drug? What can affect the solubility of a drug, or the way it dissolves in the body? Explain why a hot solvent dissolves a solid faster. What does a concentrationtime graph (or blood concentration curve) of a drug show? What is the U.S. Food and Drug Administration rule regarding the concentrationtime graphs for a brand-name drug and its generic equivalent? Answers to Student Questions By law, what must be the same for a brand-name drug and its generic equivalent? What can be different? By law, a brand-name drug and its generic equivalent must have the same active ingredients. The inactive ingredients, such as pigments, flavoring, and binders can differ. What is the role of the active ingredients in a drug? Active ingredients are the ingredients that cause a drugs effect, such as pain relief or anti-nausea. What can affect the solubility of a drug, or the way it dissolves in the body? Inactive ingredients in a drug can affect the way a drug dissolves in the body. Temperature also affects solubility. Pharmaceutical companies adjust their drugs so they dissolve at body temperature. Explain why a hot solvent dissolves a solid faster. Hot solvents dissolve solids faster because their molecules move faster than cold ones. Increased molecular motion competes with the attraction between the molecules in the solute and tends to make them come apart more easily. Increased molecular motion also causes more solvent molecules to interact with solute molecules and pull on them with more force, which makes them dissolve more. What does a concentrationtime graph (or blood concentration curve) of a drug show? A concentrationtime graph of a drug shows the concentration of a drug in the bloodstream at regular time intervals. What is the U.S. Food and Drug Administration rule regarding the concentrationtime graphs for a brand-name drug and its generic equivalent? The U.S. Food and Drug Administration rule states that when the concentrationtime graphs for a brand-name drug and its generic equivalent are compared, the difference between them should not be larger than 20% of the brand-name drugs curve. Anticipation Guide Anticipation guides help engage students by activating prior knowledge and stimulating student interest before reading. If class time permits, discuss students responses to each statement before reading each article. As they read, students should look for evidence supporting or refuting their initial responses. Directions: Before reading, in the first column, write A or D indicating your agreement or disagreement with each statement. As you read, compare your opinions with information from the article. In the space under each statement, cite information from the article that supports or refutes your original ideas. MeTextStatementThe U.S. FDA must regulate generic drugs.Some people react better to generic drugs than to brand-name drugs.By law, generic drugs and brand-name drugs must have exactly the same ingredients.Both your stomach and your small intestine have acidic environments.One significant way generics may differ from brand-name drugs is the amount of time it takes to dissolve in the body.Switching from a brand-name to a generic drug is more risky than switching from one generic drug to another generic drug.No matter what the drug, all generic and brand-name drugs must be within 20% of each other on the concentration-time graph for the drug product.By far, generic drugs are more dangerous than brand-name drugs.If one epileptic patient has a seizure after taking a drug, that drug cannot be sold any more. Reading Strategies These matrices and organizers are provided to help students locate and analyze information from the articles. Student understanding will be enhanced when they explore and evaluate the information themselves, with input from the teacher if students are struggling. Encourage students to use their own words and avoid copying entire sentences from the articles. The use of bullets helps them do this. If you use these reading strategies to evaluate student performance, you may want to develop a grading rubric such as the one below. ScoreDescriptionEvidence4ExcellentComplete; details provided; demonstrates deep understanding.3GoodComplete; few details provided; demonstrates some understanding.2FairIncomplete; few details provided; some misconceptions evident.1PoorVery incomplete; no details provided; many misconceptions evident.0Not acceptableSo incomplete that no judgment can be made about student understanding Teaching Strategies: Links to Common Core State Standards: There are several opportunities to compare alternatives in this issue of ChemMatters. For example, you might ask students to take sides and find support for one of the following: Using brand-name vs. generic drugs Driving electric cars vs. cars with internal combustion engines To help students engage with the text, ask students what questions they still have about the articles. Vocabulary that may be new to students: VOCs Internal combustion engine Important chemistry concepts that will be reinforced in this issue: Reaction rate Oxidation and reduction Directions: As you read, compare brand-name and generic drugs using the chart below. Brand-Name DrugsGeneric DrugsSimilarities Background Information (teacher information) More on the U.S. Food and Drug Administration (FDA) The approval of drugs, brand-name and generic, prescription and over-the-counter (OTC), for sale in the U.S. market is under the regulatory umbrella of the U.S. Food and Drug Administration (FDA). The FDAs Center for Drug Evaluation and Research (CDER) performs this role for human drugs, along with other drug-related monitoring. This extends beyond our idea of drugs as pills and injections; the FDA Web site states, This work covers more than just medicines. For example, fluoride toothpaste, antiperspirants, dandruff shampoos and sunscreens are all considered drugs. ( HYPERLINK "http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/default.htm" http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/default.htm) Students may also be interested to learn that a separate group within the FDA performs similar functions, but for drugs developed for use with animals. ( HYPERLINK "http://www.fda.gov/AnimalVeterinary/default.htm" http://www.fda.gov/AnimalVeterinary/default.htm) The CDERs responsibilities are summarized in the publication Center for Drug Evaluation and Research 2007 Update: Improving Public Health through Human Drugs: Reviewing drugs before marketing. FDA does not conduct the clinical studies that support marketing. A drug company seeking to sell a drug in the United States must conduct the studies intended to demonstrate effectiveness and defining the drugs risks. We monitor clinical research to ensure that people who volunteer for studies are protected and that the quality and integrity of scientific data are maintained. The company then sends us the evidence from these tests to prove the drug is safe and effective for its intended use. We assemble a team of physicians, statisticians, chemists, pharmacologists and other scientists to review the companys data and proposed use for the drug. If the drug is effective and we are convinced its health benefits outweigh its known risks, we approve it for sale. We also review drugs that you can buy over the counter without a prescription and generic versions of over-the-counter and prescription drugs. Watching for drug problems. We monitor the use of marketed drugs for unexpected health risks. If new, unanticipated risks are detected after approval, we take steps to inform the public and change how a drug is used or even remove it from the market. We monitor changes in manufacturing to ensure they will not adversely affect safety or efficacy. We evaluate reports about suspected problems from manufacturers, health-care professionals and consumers. We try to make sure an adequate supply of needed drugs is always available to patients who depend on them. Monitoring drug information and advertising. Accurate and complete information is vital to the safe use of drugs. In the past, drug companies promoted their products almost entirely to physicians. More frequently now, they are advertising directly to consumers. We oversee advertising of prescription drugs, whether to physicians or consumers. We pay particular attention to broadcast ads that can be seen by many consumers. The Federal Trade Commission regulates advertising of over-the-counter drugs. Advertisements for a drug must contain a truthful summary of information about its effectiveness, side effects and circumstances when its use should be avoided. Scientific research. We conduct and collaborate on focused laboratory research and testing. This maintains and strengthens the scientific base of our regulatory policy-making and decision-making. We focus on drug quality, safety and performance; improved technologies; new approaches to drug development and review; and regulatory standards and consistency. Protecting drug quality. In addition to setting standards for safety and effectiveness testing, we also set standards for drug quality and manufacturing processes. We work closely with manufacturers to see where streamlining can cut red tape without compromising drug quality. To ensure a safe and effective drug supply, we enforce federal requirements for drug approval, manufacturing and labeling. When necessary, we take legal action to stop distribution of products in violation of these requirements. As the pharmaceutical industry has become increasingly global, we are involved in international negotiations with other nations to harmonize standards for drug quality and the data needed to approve a new drug. This harmonization will go a long way toward reducing the number of redundant tests manufacturers do and help ensure drug quality for consumers at home and abroad. ( HYPERLINK "http://www.fda.gov/downloads/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/WhatWeDo/UCM121704.pdf" http://www.fda.gov/downloads/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/WhatWeDo/UCM121704.pdf) A major responsibility is to evaluate new drug applications. The FDA states, Since 1938, every new drug has been the subject of an approved NDA [New Drug Application] before U.S. commercialization.The NDA application is the vehicle through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing in the U.S. The data gathered during the animal studies and human clinical trials of an Investigational New Drug (IND) become part of the NDA. The documentation required in an NDA is supposed to tell the drug's whole story, including what happened during the clinical tests, what the ingredients of the drug are, the results of the animal studies, how the drug behaves in the body, and how it is manufactured, processed and packaged. ( HYPERLINK "http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/NewDrugApplicationNDA/default.htm" http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/NewDrugApplicationNDA/default.htm) The information contained in an NDA allows the FDA to determine the following information: whether the drug is safe and effective in its proposed use(s), whether the benefits of the drug outweigh the risks, whether the drug's proposed labeling is appropriate, what the labeling should contain, and whether the methods used in manufacturing the drug and the controls used to maintain the drug's quality are adequate to preserve the drug's identity, strength, quality, and purity. ( HYPERLINK "http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/NewDrugApplicationNDA/default.htm" http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/NewDrugApplicationNDA/default.htm) Even after a drug is approved by the FDA, monitoring of the drug does not stop. As stated above, the FDA continues to examine any new data and reports that arise, in particular, regarding side effects and risks of a specific drug that may not have come to light earlier. Even though we may view some drugs as completely safe either because they are widely used, have been used for a long time, or have never given us trouble when weve taken them, all drugs have a balance of risks and benefits. The FDA presents information to help consumers make decisions about medications: Although medicines can make you feel better and help you get well, it's important to know that all medicines, both prescription and over-the-counter, have risks as well as benefits. The benefits of medicines are the helpful effects you get when you use them, such as lowering blood pressure, curing infection, or relieving pain. The risks of medicines are the chances that something unwanted or unexpected could happen to you when you use them. Risks could be less serious things, such as an upset stomach, or more serious things, such as liver damage. When a medicine's benefits outweigh its known risks, the FDA considers it safe enough to approve. But before using any medicineas with many things that you do every dayyou should think through the benefits and the risks in order to make the best choice for you. There are several types of risks from medicine use: The possibility of a harmful interaction between the medicine and a food, beverage, dietary supplement (including vitamins and herbals), or another medicine. Combinations of any of these products could increase the chance that there may be interactions. The chance that the medicine may not work as expected. The possibility that the medicine may cause additional problems. ( HYPERLINK "http://www.fda.gov/drugs/resourcesforyou/consumers/ucm143558.htm" http://www.fda.gov/drugs/resourcesforyou/consumers/ucm143558.htm) If problems with a drug do come to light after its approval, different actions can be taken, such as adding new advisory information to the label about a potential side effect, or even up to the level of recalling, or removing, the drug from the market. There are several options for recalls, described by the FDA: Recalls may be conducted on a firms own initiative, by FDA request, or by FDA order under statutory authority. Class I recall: a situation in which there is a reasonable probability that the use of or exposure to a violative product will cause serious adverse health consequences or death.( Class II recall: a situation in which use of or exposure to a violative product may cause temporary or medically reversible adverse health consequences or where the probability of serious adverse health consequences is remote.( Class III recall: a situation in which use of or exposure to a violative product is not likely to cause adverse health consequences. ( HYPERLINK "http://www.fda.gov/Safety/Recalls/ucm165546.htm" http://www.fda.gov/Safety/Recalls/ucm165546.htm) One example of this that has received a lot of press over the past decade or so is Vioxx, an anti-inflammatory drug produced by the pharmaceutical/healthcare company Merck. It was a prescription medication used mainly for arthritis pain. The drug was approved by the FDA in 1999 after an expedited review. The FDA explains, Vioxx received a six-month priority review because the drug potentially provided a significant therapeutic advantage over existing approved drugs due to fewer gastrointestinal side effects, including bleeding.A product undergoing a priority review is held to the same rigorous standards for safety, efficacy, and quality that FDA expects from all drugs submitted for approval. ( HYPERLINK "http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm106290.htm" http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm106290.htm) While the drug studies did show less gastrointestinal bleeding for the drug, further study revealed an increased risk of cardiovascular problems such as heart attack or stroke. Merck eventually announced a voluntary worldwide withdrawal of the drug. Many news sources on the internet chronicle this story, with various accusations; a student research project is suggested in the Out-of-class Activities and Projects section below. Another interesting research project could involve direct-to-consumer marketing regarding prescription drugs. You can often find pharmaceutical advertising simply by leafing through a magazine or watching television. In the year 2009 alone, 4.5 billion dollars were spent on direct-to-consumer advertising. ( HYPERLINK "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278148/" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278148/) The FDA is responsible for regulating advertising for prescription drugs. Companies are not required to submit advertisements to the FDA before they are released to the public, but the FDA does monitor ads to confirm that they adhere to regulations. The FDA site describes the information such advertisements are required to share: at least one approved use for the drug, the generic name of the drug (approved brand-name drugs have an associated common scientific name, called its generic name, even if no generic version of the drug is being manufactured at that point), and all the risks of using the drug. ( HYPERLINK "http://www.fda.gov/Drugs/ResourcesForYou/Consumers/PrescriptionDrugAdvertising/UCM076768.htm" http://www.fda.gov/Drugs/ResourcesForYou/Consumers/PrescriptionDrugAdvertising/UCM076768.htm) Depending on the type of advertisement, certain information can be shortened or left out. The advertisements are not required to tell you certain information: cost, whether there is a generic version of the drug, if there is a similar drug with fewer or different risks that can treat the condition, if changes in your behavior could help your condition (such as diet and exercise), how many people have the condition the drug treats, how the drug works, how quickly the drug works (although if the ad claims it works quickly, the ad must explain what that means), and how many people who take the drug will be helped by it. ( HYPERLINK "http://www.fda.gov/Drugs/ResourcesForYou/Consumers/PrescriptionDrugAdvertising/UCM076768.htm" http://www.fda.gov/Drugs/ResourcesForYou/Consumers/PrescriptionDrugAdvertising/UCM076768.htm) Several pages on the FDA site help to educate consumers on how to be aware of this advertising and what sorts of questions to ask when viewing an ad. For example, an FDA page shows three different types of advertisements, along with two examples of each, one that follows regulations and one that doesnt. ( HYPERLINK "http://www.fda.gov/Drugs/ResourcesForYou/Consumers/PrescriptionDrugAdvertising/default.htm" http://www.fda.gov/Drugs/ResourcesForYou/Consumers/PrescriptionDrugAdvertising/default.htm) Another page lists questions to consider when you see an ad, such as What condition does this drug treat?, Why do I think that I might have this condition?, How will this drug affect other drugs I am taking?, Is there a less costly drug I could use to treat my condition? ( HYPERLINK "http://www.fda.gov/Drugs/ResourcesForYou/Consumers/PrescriptionDrugAdvertising/ucm071915.htm" http://www.fda.gov/Drugs/ResourcesForYou/Consumers/PrescriptionDrugAdvertising/ucm071915.htm) There are various arguments for and against such advertising. For example, some argue that it informs, educates, and empowers patients, promotes patient dialogue with health care providers, and removes the stigma associated with certain diseases. ( HYPERLINK "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278148/" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278148/) Others believe that it promotes new drugs before safety profiles are fully known, leads to inappropriate prescribing, and strains relationships with health care providers. ( HYPERLINK "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278148/" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278148/) The topic provides a good opportunity to discuss how to make informed choices as a consumer. More on brand-name drugs The basics of brand-name compared to generic drugs are succinctly summarized: A brand name drug is a medicine thats discovered, developed and marketed by a pharmaceutical company. Once a new drug is discovered, the company files for a patent to protect against other companies making copies and selling the drug. At this point the drug has two names: a generic name thats the drugs common scientific name and a brand name to make it stand out in the marketplace. This is true of prescription drugs as well as over-the-counter drugs. An example is the pain reliever Tylenol. The brand name is Tylenol and the generic name is acetaminophen. Generic drugs have the same active ingredients as brand name drugs already approved by the Food and Drug Administration (FDA). Generics only become available after the patent expires on a brand name drug. Patent periods may last up to 20 years on some drugs. The same company that makes the brand name drug may also produce the generic version. Or, a different company might produce it. ( HYPERLINK "http://www.dbsalliance.org/pdfs/GenericRx.pdf" http://www.dbsalliance.org/pdfs/GenericRx.pdf) The general path that a potential new drug takes is described in a December 13, 2004, Scientific American article: The development of any new pharmaceutical is a complex and expensive project. In many instances, the research divisions within pharmaceutical companies spend years studying aspects of the biology and biochemistry of the disease in question (malaria, cancer or bacterial infections, for example) in an effort to develop an approach to attack the disease. Once the biology of the disease is understood and an assay or animal model is in place, medicinal chemists begin to prepare potential chemical inhibitors. From initial results in the biological system, the chemists then prepare new, and hopefully improved, lead compounds. This sort of teamwork between the chemists and biologists often takes years before a final group of lead compounds is ready for more significant evaluation. At this point, a candidate drug is evaluated for toxicity, efficacy and other properties in an animal model (rats or dogs, for instance). This evaluation process may last years. Assuming that the drug candidate is successful in these tests, it then enters into Phase 1, Phase 2 and, finally, Phase 3 clinical trials in humans. The FDA establishes the number of patients required for each phase of the clinical trials according to guidelines based on the disease being treated. For example, a drug candidate for a disease that afflicts only 10,000 people would have a smaller number of patients in its trials than would a potential drug to fight a disease that afflicts millions such as high blood pressure. At the end of the clinical trials the company presents its data to the FDA, which then decides whether or not to approve the drug for sale to the public. (HYPERLINK "http://www.scientificamerican.com/article.cfm?id=whats-the-difference-betw-2004-12-13&page=2"http://www.scientificamerican.com/article.cfm?id=whats-the-difference-betw-2004-12-13&page=2) The three phases of human clinical trials have different types and numbers of subjects: In phase I, a small number of usually healthy volunteers are tested to establish safe dosages and to gather information on the absorption, distribution, metabolic effects, excretion, and toxicity of the compound. To conduct clinical testing in the United States, a manufacturer must first file an investigational new drug application (IND) with the FDA. However, initiation of human testing can, and often does, occur first outside the United States. Phase II trials are conducted with subjects who have the targeted disease or condition and are designed to obtain evidence on safety and preliminary data on efficacy. The number of subjects tested in this phase is larger than in phase I and may number in the hundreds. The final pre-approval clinical testing phase, phase III, typically consists of a number of large-scale (often multi-center) trials that are designed to firmly establish efficacy and to uncover side-effects that occur infrequently. The number of subjects in phase III trials for a compound can total in the thousands. Once drug developers believe that they have enough evidence of safety and efficacy, they will compile the results of their testing in an application to regulatory authorities for marketing approval. In the United States, manufacturers submit a new drug application (NDA) or a biological license application (BLA) to the FDA for review and approval. ( HYPERLINK "http://moglen.law.columbia.edu/twiki/pub/LawNetSoc/BahradSokhansanjFirstPaper/22JHealthEcon151_drug_development_costs_2003.pdf" http://moglen.law.columbia.edu/twiki/pub/LawNetSoc/BahradSokhansanjFirstPaper/22JHealthEcon151_drug_development_costs_2003.pdf) A poster showing the top 200 pharmaceutical products based on the amounts of retail sales in the United States in 2011 shows some of the major players and top drug names you may have heard of in the brand-name drug market. ( HYPERLINK "http://cbc.arizona.edu/njardarson/group/sites/default/files/Top 200 Pharmaceutical Products by US Retail Sales in 2011_small.pdf" http://cbc.arizona.edu/njardarson/group/sites/default/files/Top 200 Pharmaceutical Products by US Retail Sales in 2011_small.pdf) The top 10 brand-name drugs were: Brand name of drugCompanyType of drugAmount spentLipitorPfizerCholest. & trigly. regulator$7,688 millionPlavixBristol-Myers SquibbPlatelet aggr. inhibitors$6,711 millionNexiumAstraZenecaAntiulcerants$6,156 millionAbilifyOtsukaAntipsychotics$5,194 millionAdvair DiskusGlaxoSmithKlineCorticoids$4,637 millionSeroquelAstraZenecaAntipsychotics$4,637 millionSingulairMerckAntileuk. antiasthmatics$4,593 millionCrestorAstraZenecaCholest. & trigly. regulator$4,404 millionCymbaltaLillyAntidepress. & mood stab.$3,666 millionHumiraAbbottSpec. antirheumatic agent$3,531 million( HYPERLINK "http://cbc.arizona.edu/njardarson/group/sites/default/files/Top 200 Pharmaceutical Products by US Retail Sales in 2011_small.pdf" http://cbc.arizona.edu/njardarson/group/sites/default/files/Top 200 Pharmaceutical Products by US Retail Sales in 2011_small.pdf.) The top pharmaceutical companies for 2012 are summarized on the CNN Money site. ( HYPERLINK "http://money.cnn.com/magazines/fortune/fortune500/2012/industries/21/" http://money.cnn.com/magazines/fortune/fortune500/2012/industries/21/) The top company was Pfizer, with a Fortune 500 ranking of 40, revenues of $67,932 million, and profits of $10,009 million; rounding out the top five were Johnson & Johnson, Merck, Abbott Laboratories, and Eli Lilly. Pharmaceutical companies are big business, with large amounts of money spent annually on their products by consumers. However, the time and money spent on average to get just one drug to market is also large. Different numbers have been thrown around. For example, a 2009 article in Canadian Medical Association Journal suggests an estimated cost to develop test, and bring one drug to market$1.3 to $1.7 billion [U.S. dollars]. ( HYPERLINK "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630351/" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630351/) A 2012 Forbes article mentions similar numbers that have been reported, but makes a case to suggest that they may be even higher. Forbes took Munos count of drug approvals for the major pharmas and combined it with their research and development spending as reported in annual earnings filings going back fifteen years, pulled from a Thomson Reuters database using FactSet. We adjusted all the figures for inflation. Using both drug approvals and research budgets since 1997 keeps the estimates being skewed by short-term periods when R&D budgets or drug approvals changed dramatically. The range of money spent is stunning. AstraZeneca has spent $12 billion in research money for every new drug approved, as much as the top-selling medicine ever generated in annual sales; Amgen spent just $3.7 billion. At $12 billion per drug, inventing medicines is a pretty unsustainable business. At $3.7 billion, you might just be able to make money (a new medicine can probably keep generating revenue for ten years; invent one a year at that rate and youll do well). There are lots of expenses here. A single clinical trial can cost $100 million at the high end, and the combined cost of manufacturing and clinical testing for some drugs has added up to $1 billion. But the main expense is failure. AstraZeneca does badly by this measure because it has had so few new drugs hit the market. Eli Lilly spent roughly the same amount on R&D, but got twice as many new medicines approved over that 15 year period, ad so spent just $4.5 billion per drug. ( HYPERLINK "http://www.forbes.com/sites/matthewherper/2012/02/10/the-truly-staggering-cost-of-inventing-new-drugs/" http://www.forbes.com/sites/matthewherper/2012/02/10/the-truly-staggering-cost-of-inventing-new-drugs/) As mentioned above, the cost of developing a new drug goes beyond the cost of running clinical trials and supporting researchers salaries. It also includes drug research by a company that doesnt result in a new product being offered on the market. For example, an article in The Wall Street Journal states, Currently, bringing one new drug to market takes roughly 14 years, at a cost of about $1.3 billion. For every drug that makes it to market, more than 50 other research programs fail. After all that, only two of every 10 newly approved drugs will be profitable. Those profits must fund not only all the research programs that failed, but also all the drugs that are launched but lose money. When the industry was producing a steady stream of blockbuster drugs, as it did beginning in the 1990s (for example, all the AIDS drugs), the math worked in its favor. But in recent years the numbers have turned against the drug industry, for several reasons. For one, the Food and Drug Administration has become more risk-averse in the wake of the 2004 Vioxx debacle. Drug makers are now required to conduct more studies with many more subjects. That adds to costs and stretches out development times. And every year spent in clinical trials equals one year of lost patent coverage. In 1968, when development time was much shorter than today, most drugs had an effective patent life of about 17 years. Now companies usually have only about 11 years of market exclusivity for their drugs. And this number is expected to continue dropping as development times grow even longerapproaching a point where the costs and risks of development outweigh the rewards and research will stop ( HYPERLINK "http://online.wsj.com/article/SB10001424052970204542404577156993191655000.html" http://online.wsj.com/article/SB10001424052970204542404577156993191655000.html) Another cost is described: the financial cost of tying up investment capital in multiyear drug development projects, earning no return until and unless a project succeeds. That opportunity cost of capital reflects forgone interest or earnings from alternative uses of the capital. (Opportunity costs are common to all innovative industries, but they are particularly large for pharmaceutical firms because of the relatively long time that is often required to develop a new drug.) ( HYPERLINK "http://www.cbo.gov/sites/default/files/cbofiles/ftpdocs/76xx/doc7615/10-02-drugr-d.pdf" http://www.cbo.gov/sites/default/files/cbofiles/ftpdocs/76xx/doc7615/10-02-drugr-d.pdf) The number of applications to the FDA for approval of new drugs, called new molecular entities (NMEs) has been on a decline based on data from 1996 to current. ( HYPERLINK "http://www.fda.gov/downloads/AboutFDA/Transparency/Basics/UCM247465.pdf" http://www.fda.gov/downloads/AboutFDA/Transparency/Basics/UCM247465.pdf) The same site summarizes the number of NMEs approved each year over the past decade: YearNMEs approved200124200217200321200436200520200622200718200824200926201021 ( HYPERLINK "http://www.fda.gov/downloads/AboutFDA/Transparency/Basics/UCM247465.pdf" http://www.fda.gov/downloads/AboutFDA/Transparency/Basics/UCM247465.pdf) Often drug applications to the FDA are not for new compounds, but rather for slightly modified forms, or new uses for drugs that are already on the market. More on Generic Drugs The use of generic drugs has been on the rise for the past several years. Statistics show: In 2010, generic medicines accounted for more than three-quarters of the prescriptions dispensed by retail drugstores and long-term care facilities. The exact figure is 78 percent, a historic high, that was up four percentage points from 2009. Generic use has climbed steadily from 63 percent of dispensed prescriptions in 2006. ( HYPERLINK "http://www.npr.org/blogs/health/2011/05/16/135538006/3-in-4-prescriptions-are-now-for-generic-drugs" http://www.npr.org/blogs/health/2011/05/16/135538006/3-in-4-prescriptions-are-now-for-generic-drugs) As stated in the Washam article, users of generic drugs can expect that a generic substitute for a brand-name drug will contain the same active ingredient(s), but likely not identical inactive ingredients. The similarities and differences between generic and brand-name drugs are summarized in a document from the Depression and Bipolar Support Alliance: The Similarities According to the FDA, to substitute a generic for a brand name drug: It must contain the same active ingredients (the chemical substance that makes the drug work). It must have the same dosage strength (the amount of active ingredients, for example 20 mg or 40 mg). It must be the same dosage form (that is, it needs to be available in the same form as the originalfor example, as a liquid, pill, etc.). It must have the same route of administration (the way the medication is introduced into the body). It must deliver similar amounts of the drug to the bloodstream (that is, it needs to deliver a comparable amount of the drug into the bloodstream within a similar time period as the brand name drug). The Differences Heres how generics and brand name drugs differ: They look different. (Federal law requires this.) They could have different sizes, shapes, colors or markings. They have different names. They might have different inactive ingredients. Drugs are made up of both active and inactive ingredients. Some people may be sensitive to inactive ingredients. For example, some people have reactions to certain dyes used in some drugs. The generic costs less than the brand name drug. The cash price and insurance co-pay is usually lower. Generics can cost between 20 and 80 percent less, but keep in mind that cost is only one factor when considering the right medication for your condition. Generics vary by manufacturer, which means you could receive different versions based on where you purchase your medications and what type of generic they dispense. Different pharmacies carry different generics. Even the same pharmacy may change generic suppliers. ( HYPERLINK "http://www.dbsalliance.org/pdfs/GenericRx.pdf" http://www.dbsalliance.org/pdfs/GenericRx.pdf) In the U.S., a generic version of a brand-name drug may be marketed by a manufacturer only after the patent on the brand-name drug expires, and after the manufacturer has completed a successful application to the FDA to offer the generic. Typically the length of a drug patent is 20 years. The patent is meant to offer protection to the company who first developed a particular innovative drug, giving them exclusive rights to market and sell that particular drug for the length of the patent. This allows them to somewhat recoup the extensive costs of development and bringing a drug to market. However, in reality, this does not mean that the manufacturer is able to exclusively offer the drug on the market for 20 years. A manufacturer will usually apply for the patent while the drug is still in development. It can take over a decade for a drug to be completely developed, tested, and approved for the market by the FDA, leaving a much smaller fraction of the 20 years left for exclusive sales. After the patent expiration, a brand-name drug can be made into a generic drug. The manufacturer of a generic drug could be the same company that makes the brand-name drug, or an entirely different company, such as one that specializes in offering generic drugs (e.g. Teva Pharmaceuticals,  HYPERLINK "http://www.tevagenerics.com/" http://www.tevagenerics.com/). In order to offer a generic drug on the U.S. market, the manufacturer must submit an application to the FDA, much like the manufacturer of a brand-name drug. However, a major difference is that an application for a generic drug does not need to redo clinical testing of the drug, which is one reason that generic drugs can be offered at a lower cost than brand-name drugs. The FDA Web site briefly summarizes the application process for a generic drug: Drug companies must submit an abbreviated new drug application (ANDA) for approval to market a generic product. The Drug Price Competition and Patent Term Restoration Act of 1984, more commonly known as the Hatch-Waxman Act, made ANDAs possible by creating a compromise in the drug industry. Generic drug companies gained greater access to the market for prescription drugs, and innovator companies gained restoration of patent life of their products lost during FDA's approval process. The ANDA process does not require the drug sponsor to repeat costly animal and clinical research on ingredients or dosage forms already approved for safety and effectiveness. This applies to drugs first marketed after 1962. Health professionals and consumers can be assured that FDA approved generic drugs have met the same rigid standards as the innovator drug. To gain FDA approval, a generic drug must: contain the same active ingredients as the innovator drug (inactive ingredients may vary) be identical in strength, dosage form, and route of administration have the same use indications be bioequivalent meet the same batch requirements for identity, strength, purity, and quality be manufactured under the same strict standards of FDA's good manufacturing practice regulations required for innovator products ( HYPERLINK "http://www.fda.gov/Drugs/ResourcesForYou/Consumers/QuestionsAnswers/ucm100100.htm" http://www.fda.gov/Drugs/ResourcesForYou/Consumers/QuestionsAnswers/ucm100100.htm) The FDA defines bioequivalence as: The absence of a significant difference in the rate and extent to which the active ingredient or active moiety in pharmaceutical equivalents or pharmaceutical alternatives becomes available at the site of drug action when administered at the same molar dose under similar conditions in an appropriately designed study. ( HYPERLINK "http://www.fda.gov/downloads/Drugs/.../Guidances/ucm070124.pdf" http://www.fda.gov/downloads/Drugs/.../Guidances/ucm070124.pdf) A December 13, 2004, Scientific American article provided this brief summary: The major difference between a brand-name pharmaceutical and its generic counterpart is neither chemistry nor quality, but whether the drug is still under patent protection by the company that initially developed it. ( HYPERLINK "http://www.scientificamerican.com/article.cfm?id=whats-the-difference-betw-2004-12-13" http://www.scientificamerican.com/article.cfm?id=whats-the-difference-betw-2004-12-13) The Washam article discusses problems that can arise when a patient switches from one drug to another, whether it be from brand-name to generic, vice versa, or a generic to another generic. The FDA site presents data that may help to dispel the idea consumers may have that there can be a very large difference between generic and brand-name drugs. It states: FACT: FDA does not allow a 45 percent difference in the effectiveness of the generic drug product. FDA recently evaluated 2,070 human studies conducted between 1996 and 2007. These studies compared the absorption of brand name and generic drugs into a persons body. These studies were submitted to FDA to support approval of generics. The average difference in absorption into the body between the generic and the brand name was 3.5 percent [Davit et al. Comparing generic and innovator drugs: a review of 12 years of bioequivalence data from the United States Food and Drug Administration. Ann Pharmacother. 2009; 43(10):1583-97.]. Some generics were absorbed slightly more, some slightly less. This amount of difference would be expected and acceptable, whether for one batch of brand name drug tested against another batch of the same brand, or for a generic tested against a brand name drug. In fact, there have been studies in which brand name drugs were compared with themselves as well as with a generic.As a rule, the difference for the generic-to-brand comparison was about the same as the brand-to-brand comparison. Any generic drug modeled after a single, brand name drug must perform approximately the same in the body as the brand name drug. There will always be a slight, but not medically important, level of natural variability just as there is for one batch of brand name drug compared to the next batch of brand name product. ( HYPERLINK "http://www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/understandinggenericdrugs/ucm167991.htm" http://www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/understandinggenericdrugs/ucm167991.htm) Each year, the patents of certain brand-name drugs expire, making them fair game for generic manufacturers. A name students might recognize is Lipitor, a drug used to treat high cholesterol, that was eligible for generic manufacturing in late 2011. The FDA approved the first generic version, atorvastatin calcium tablets, on November 30, 2011. ( HYPERLINK "http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm281817.htm" http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm281817.htm) Certain drugs may have more than one manufacturer producing a generic version; the competition between generic companies can serve to drive down the cost of generic drugs even further. A 2012 article describes a patent cliff (a take on the term financial cliff often tossed around in the news at the end of 2012) for generic drug manufacturers. Compared to the number of brand-name drugs whose patent expired in 2012, the number in 2013 will be much lower, resulting in fewer possibilities to add to the lineup of generic drug moneymakers for a company. The continued decline in the number of new molecular entities, or new drugs, mentioned above, will have a similar effect in the future, leaving manufacturers looking for new options. This year [2012], more than 40 brand-name drugs valued at $35 billion in annual sales lost their patent protection, meaning that generic companies were permitted to make their own lower-priced versions of well-known drugs like Plavix, Lexapro and Seroquel and share in the profits that had exclusively belonged to the brands. Next year, the value of drugs scheduled to lose their patents and be sold as generics is expected to decline by more than half, to about $17 billion, according to an analysis by Crdit Agricole Securities.The patent cliff is over, said Kim Vukhac, an analyst for Crdit Agricole. Thats great for large pharma, but that also means the opportunities theoretically have dried up for generics. In response, many generic drug makers are scrambling to redefine themselves, whether by specializing in hard-to-make drugs, selling branded products or making large acquisitions. The large generics company Watson acquired a European competitor, Actavis, in October, vaulting it from the fifth- to the third-largest generic drug maker worldwide. ( HYPERLINK "http://www.nytimes.com/2012/12/04/business/generic-drug-makers-facing-squeeze-on-revenue.html?pagewanted=all&_r=0" http://www.nytimes.com/2012/12/04/business/generic-drug-makers-facing-squeeze-on-revenue.html?pagewanted=all&_r=0) Connections to Chemistry Concepts (for correlation to course curriculum) SolubilityThe solubility of drugs is mentioned in the article, including where and when a drug dissolves, such as in the stomach or the small intestine, and the adjustment of a drug to dissolve at body temperature. It also describes the effect temperature has on solubility. ConcentrationThe concentration of drugs in the bloodstream and the typical units used for their reporting can be discussed. The article includes a concentrationtime graph (blood concentration curve) for two drugs; instructors can emphasize the reasons for the shape of the curve. Organic/BiochemistryAlthough the structures of drug molecules are fairly complex, students can compare and contrast structures for various functional groups. Possible Student Misconceptions (to aid teacher in addressing misconceptions) It doesnt matter if you take a brand-name or generic form of a particular medication. In many cases, it does not matter, but sometimes a patient reacts better to either the generic or the brand-name drug. Switching between two generic types of the same drug can also trigger a problem in some patients. The brand-name and generic forms of a particular drug are identical. By law, the brand-name and generic forms of a particular drug must have the same active ingredients, but the inactive ingredients, such as pigments, flavoring, and binders often differ. In addition, the typical concentration of a drug in the bloodstream over time is allowed to slightly differ between a brand-name drug and its generic equivalent. Every brand-name drug has a generic drug. New brand-name drugs are protected by patents for approximately 1520 years, which means that other manufacturers may not make and sell a generic version of the drug. Even when patent protection expires, other manufacturers need to submit an application to the FDA to be able to sell the generic drug, or manufacturers may not be interested in pursuing a generic version. Anticipating Student Questions (answers to questions students might ask in class) Why is a generic drug so much cheaper than the brand-name? Companies with brand-name products have spent substantial amounts of money to initially develop and test the drugs, which generic manufacturers do not have to do. These companies also tend to spend much more money on marketing and advertising than would a generic manufacturer. If generic drugs are so much cheaper, why would anyone choose to use a brand-name instead? As discussed in the article, even though the active ingredients of a brand-name vs. generic drug must be identical, a patients response to a particular drug can actually vary. A brand-name drug might work better for someone, or one particular generic. Or, someone may simply prefer one over the other for other reasons; for example, the author usually purchases the brand-name Advil instead of generic ibuprofen because of her preference for the slightly-flavored smooth coating on the pill. In-class Activities (lesson ideas, including labs & demonstrations) Students can investigate the effect different variables have on how fast sugar dissolves in water. For example, students could vary the temperature of the water, whether they stir the solution or not, and the form of the sugar (cubes, regular, superfine). Two such experiments available online are  HYPERLINK "http://atlantis.coe.uh.edu/texasipc/units/solution/sugar.pdf" http://atlantis.coe.uh.edu/texasipc/units/solution/sugar.pdf and  HYPERLINK "http://www.mrsec.psu.edu/education/nano-activities/nano-silver/oh_sugar_sugar/oh_sugar_sugar.pdf" http://www.mrsec.psu.edu/education/nano-activities/nano-silver/oh_sugar_sugar/oh_sugar_sugar.pdf. The second is designed for younger students. The December 2001 ChemMatters Teachers Guide offered the suggested activity: You could hold a Can you discover the winning drug? contest. Lets say that only one in 100 (or choose whatever number you like) organisms offers the promise of containing a potentially useful drug. Then lets say that only 1 in 100 (or choose another number) compounds that are isolated prove to be effective. Then lets say that only one in 50 make it through Phase 1 trials, one in 10 through Phase 2 trials, and one in 10 through Phase 3 trials. Present students with a piece of paper on which 100 (or the number you choose) boxes are drawn. Only you know which box contains the organism that holds the potentially useful drug. Have students select a box. If any students select correctly, present them with another piece of paper containing another 100 (or whatever) boxes, only one of which contains an effective compound. Continue this. Will any student EVER actually end up selecting correctly all the time until he/she gets to the one drug that makes it to the marketplace? While this may not be a completely realistic exercise, it should allow students to see to what extent the search for effective, safe new drugs is the proverbial needle in a haystack exercise. (p 6) A collection of downloadable pharmaceutical posters created by a research group at the University of Arizona graphically summarizes the top brand-name and generic drugs by sales and by total U.S. prescriptions for various years. The posters could be used to highlight similarities and differences between different drug structures, the huge array of available pharmaceuticals, and the large amount of money spent each year on drugs. ( HYPERLINK "http://cbc.arizona.edu/njardarson/group/top-pharmaceuticals-poster" http://cbc.arizona.edu/njardarson/group/top-pharmaceuticals-poster) The posters were described with sample questions to ask higher level students in the Journal of Chemical Education (JCE) article A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives (McGrath, N. A.; Brichacek, M.; Njardarson, J. T. J. Chem. Educ. 2010, 87 (12), pp 13481349,  HYPERLINK "http://pubs.acs.org/doi/abs/10.1021/ed1003806" http://pubs.acs.org/doi/abs/10.1021/ed1003806). The article is available to JCE subscribers. The author of the JCE article The Analysis of a Drug Circular as a First-Day Assignment for Freshman Chemistry gives freshman-level college students an advertisement for a drug on the first day of class, asking them to return the next day with answers to questions such as What is the generic name for the active ingredient?, What is the chemical name? How does it work?, Who manufactures it? Are there any drugs that should not be taken with it?. The article is available to JCE subscribers. (Millevolte, A. J. J. Chem. Educ. 1995, 72 (12), p 1085,  HYPERLINK "http://pubs.acs.org/doi/abs/10.1021/ed072p1085" http://pubs.acs.org/doi/abs/10.1021/ed072p1085) The JCE activity Whats the Diagnosis? An Inquiry-Based Activity Focusing on MoleMass Conversions presents two brief descriptions of medical cases and blood concentration data for various minerals in units of moles per deciliter. Students must determine how to convert the data to match the units of normal concentration ranges reported in the literature to diagnose the problem. The article and supporting handouts are available to JCE subscribers. (Bruck, L. B.; Towns, M. H. J. Chem. Educ. 2011, 88 (4), pp 440442,  HYPERLINK "http://pubs.acs.org/doi/abs/10.1021/ed100466j" http://pubs.acs.org/doi/abs/10.1021/ed100466j) Out-of-class Activities and Projects (student research, class projects) As described above in the section More on the FDA, the approval and recall of the drug Vioxx has garnered a lot of press over the years. Students could research the timeline and story and evaluate reports of wrongdoing of both the FDA and Merck. For example, a few internet sources are a timeline of events on the National Public Radio site ( HYPERLINK "http://www.npr.org/templates/story/story.php?storyId=5470430" http://www.npr.org/templates/story/story.php?storyId=5470430), Congressional testimony by the FDA ( HYPERLINK "http://www.fda.gov/NewsEvents/Testimony/ucm113235.htm" http://www.fda.gov/NewsEvents/Testimony/ucm113235.htm), a 2011 article from The New York Times reporting on a settlement by Merck ( HYPERLINK "http://www.nytimes.com/2011/11/23/business/merck-agrees-to-pay-950-million-in-vioxx-case.html" http://www.nytimes.com/2011/11/23/business/merck-agrees-to-pay-950-million-in-vioxx-case.html), and a Harvard Law student paper summarizing the story ( HYPERLINK "http://leda.law.harvard.edu/leda/data/783/Mancinelli06.pdf" http://leda.law.harvard.edu/leda/data/783/Mancinelli06.pdf). The February 2004 ChemMatters Teachers Guide described a project on investigating the way different pain relievers are marketed. Students could also research how brand-name drugs are now marketed to consumers instead of just physicians through magazine ads and television commercials. The number of different over-the-counter pain relievers being sold is staggering. Currently there are about 150 different brand names to choose from, even though the actual number of different choices is rather limited. As might be expected, manufacturers go to great lengths to try and market their product in such a way that consumers will select it from all the other available choices. A good project, or even a class activity, would be to have students go their local drugstore, examine the choices available, write down and compare the actual ingredients, and then evaluate how different the different products actually are. What were the actual differences in the contained ingredients? How were the products presentedwhat kinds of words and phrases are being used to sell the product? What were the differences in cost per dosage? Did it appear that the cost differences were justified? (p 32) References (non-Web-based information sources)  SHAPE \* MERGEFORMAT  The ChemMatters article Trolling the Seas for New Medicines discusses the ocean as a source of chemical compounds that could be potential medicines. (Black, H. Trolling the Seas for New Medicines. ChemMatters 2001, 19 (4), pp 67) The Aspirin Effect: Pain Relief and More describes how nonsteroidal anti-inflammatory drugs such as aspirin and ibuprofen work in the body. (Kimbrough, D. R. The Aspirin Effect: Pain Relief and More. ChemMatters 2004, 22 (1), pp 79,  HYPERLINK "http://portal.acs.org/portal/PublicWebSite/education/resources/highschool/chemmatters/CTP_005370" http://portal.acs.org/portal/PublicWebSite/education/resources/highschool/chemmatters/CTP_005370) Students can learn more about a different method of drug deliverythe transdermal patchhere: Herlocker, H. The Transdermal Patch: Driving Drugs Skin Deep. ChemMatters 2004, 22 (4), pp 1719. ( HYPERLINK "http://portal.acs.org/portal/PublicWebSite/education/resources/highschool/chemmatters/CTP_005402" http://portal.acs.org/portal/PublicWebSite/education/resources/highschool/chemmatters/CTP_005402) A related topic is the appropriate disposal of pharmaceuticals and how traces of drugs can enter the water supply. (Washam, C. Drugs Down the Drain: The Drugs You Swallow, the Water You Drink. ChemMatters 2011, 29 (1), pp 1113,  HYPERLINK "http://portal.acs.org/portal/PublicWebSite/education/resources/highschool/chemmatters/CNBP_026576" http://portal.acs.org/portal/PublicWebSite/education/resources/highschool/chemmatters/CNBP_026576) Web sites for Additional Information (Web-based information sources) More sites on the U.S. Food and Drug Administration (FDA) The FDAs Center for Drug Evaluation and Research offers several educational tutorials designed for health care professionals as well as consumers. These include the 90-minute course The Past, Present, and Future of FDA Human Drug Regulation and Medicines in My HomeAn Interactive Home, to help consumers from adolescence to adulthood understand how to use a drug facts label. ( HYPERLINK "http://www.fda.gov/training/forhealthprofessionals/default.htm" http://www.fda.gov/training/forhealthprofessionals/default.htm) Part of the FDAs job is to regulate what is called direct-to-consumer pharmaceutical advertising. A 2011 paper in Pharmacy & Therapeutics discusses these regulations and presents arguments for and against such advertisements. ( HYPERLINK "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278148/" http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278148/) An online database of drugs approved the FDA can be searched or browsed online at  HYPERLINK "http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Search_Drug_Name" http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Search_Drug_Name. More sites on Brand-Name Drugs The National Library of Medicine has a drug information portal of over 36,000 drugs that can be searched in different ways. ( HYPERLINK "http://druginfo.nlm.nih.gov/drugportal/drugportal.jsp" http://druginfo.nlm.nih.gov/drugportal/drugportal.jsp) The National Institutes of Health offers this page with personal stories from clinical trial volunteers and researchers. Additional links on the left side of the page take the user to additional information on clinical trials. ( HYPERLINK "http://www.nih.gov/health/clinicaltrials/stories/index.htm" http://www.nih.gov/health/clinicaltrials/stories/index.htm) A January 23, 2012 The Wall Street Journal article presented two opposite viewpoints to the title question, Should Patents on Pharmaceuticals Be Extended to Encourage Innovation? ( HYPERLINK "http://online.wsj.com/article/SB10001424052970204542404577156993191655000.html" http://online.wsj.com/article/SB10001424052970204542404577156993191655000.html) A November 28, 2012 The New York Times article discusses the recent increase in price in brand-name drugs and decrease in price of generic drugs. ( HYPERLINK "http://www.nytimes.com/2012/11/29/business/cost-of-brand-name-prescription-medicines-soaring.html" http://www.nytimes.com/2012/11/29/business/cost-of-brand-name-prescription-medicines-soaring.html) A report highlights work done by a high school student to help develop an anti-obesity drug. ( HYPERLINK "http://news.vanderbilt.edu/2012/07/high-school-student-speeds-anti-obesity-research-at-vu/" http://news.vanderbilt.edu/2012/07/high-school-student-speeds-anti-obesity-research-at-vu/) An HHMI Ask a Scientist column answers the question Why do medicines expire after a certain period of time? It states that an FDA drug application must include evidence of a drugs shelf life. ( HYPERLINK "http://www.hhmi.org/bulletin/aug2007/pdf/ask_scientist.pdf" http://www.hhmi.org/bulletin/aug2007/pdf/ask_scientist.pdf) More sites on Generic Drugs A short column on the Mayo Clinic Web site answers the question: Brand-name vs. Generic Drugs: Is One Better than the Other? ( HYPERLINK "http://www.mayoclinic.org/medical-edge-newspaper-2012/feb-03b.html" http://www.mayoclinic.org/medical-edge-newspaper-2012/feb-03b.html) The U.S. Food and Drug Administration site lists generic drug approvals by month and year, from 2001 through the current year (2012). ( HYPERLINK "http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/DrugandBiologicApprovalReports/ANDAGenericDrugApprovals/default.htm" http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/DrugandBiologicApprovalReports/ANDAGenericDrugApprovals/default.htm) A U.S. Food and Drug Administration page includes a discussion of Facts about Generic Drugs with an accompanying infographic. ( HYPERLINK "http://www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/understandinggenericdrugs/ucm167991.htm" http://www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/understandinggenericdrugs/ucm167991.htm) A collection of educational resources for educators, health care professionals, and consumers, such as brochures, posters, and multimedia presentations about generic drugs are available from the FDA for download. ( HYPERLINK "http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/UnderstandingGenericDrugs/ucm169209.htm" http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/UnderstandingGenericDrugs/ucm169209.htm) A description of how to find the generic equivalent to a brand-name drug is described, along with a link to the Electronic Orange Book that lists drug products approved by the FDA. ( HYPERLINK "http://answers.usa.gov/system/selfservice.controller?CONFIGURATION=1000&PARTITION_ID=1&CMD=VIEW_ARTICLE&ARTICLE_ID=10966&USERTYPE=1&LANGUAGE=en&COUNTRY=US" http://answers.usa.gov/system/selfservice.controller?CONFIGURATION=1000&PARTITION_ID=1&CMD=VIEW_ARTICLE&ARTICLE_ID=10966&USERTYPE=1&LANGUAGE=en&COUNTRY=US) More Web sites on Teacher Information and Lesson Plans (sites geared specifically to teachers) Drs. Elizabeth M. Vogel Taylor and Catherine L. Drennan from the Massachusetts Institute of Technology present a short article Redox chemistry and hydrogen bonding in drug design: Using human health examples to inspire your high school chemistry students, using the examples of brand-name drugs Cipro (antibiotic), Paxil (antidepressant), and Januvia (anti-diabetic). ( HYPERLINK "http://educationgroup.mit.edu/HHMIEducationGroup/wp-content/uploads/2011/10/Drennan2.pdf" http://educationgroup.mit.edu/HHMIEducationGroup/wp-content/uploads/2011/10/Drennan2.pdf) A document describes the Pharmacology Education Partnership (PEP) project, curriculum modules designed for high school biology and chemistry teachers and students. It also contains a link to the PEP Web site ( HYPERLINK "http://www.thepepproject.net" http://www.thepepproject.net) where the modules can be found. ( HYPERLINK "http://www.iuphar.org/sections/teaching/docs/ASPET_PEP_Schwartz-Bloom.pdf" http://www.iuphar.org/sections/teaching/docs/ASPET_PEP_Schwartz-Bloom.pdf)     PAGE  PAGE 24 The references below can be found on the ChemMatters 25-year CD (which includes all articles published during the years 1983 through 2008). The CD is available from ACS for $30 (or a site/school license is available for $105) at this site:  HYPERLINK "http://www.acs.org/chemmatters" http://www.acs.org/chemmatters. (At the right of the screen, click on the ChemMatters CD image like the one at the right.) 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