ࡱ> knhijs bjbj2)2) BPCfPCf$CDD++++++++8",/+XDR0p0000 22<3 $R +83 2 28383 ++004VVV83J+0+0V83VV 0@06PGZ4Ӱ(0XTHh r+T8383V8383838383 O838383X83838383838383838383838383DX *: CURRICULUM VITAE NAME: Jian-Hua Mao Position: Geneticist Senior Scientist Address: Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory 1 Cyclotron Road, MS# 977, Berkeley, CA 94720 Phone: (510) 486-6204 E-mail:  HYPERLINK "mailto:JHMao@lbl.gov" JHMao@lbl.gov EDUCATION: 1982-1986 B. Sc in Applied Mathematics, Southeast University, Nanjing, China 1986-1989 M. Medical Sc in Biostatistics and Cancer Epidemiology, Department of Biomathematics and Biostatistics, Beijing Medical University (now Peking University Health Science Center), Beijing, China. 1993-1997 Ph. D in Cancer Genetics, Department of Radiation Oncology, University of Glasgow, Glasgow, UK. 1997-1999 Postdoc in Cancer Genetics Department of Medical Oncology, University of Glasgow, Glasgow, UK. PRINCIPAL POSITION HELD: 1989-1991 Department of Biomathematics and Biostatistics, Beijing Medical University, China Assistant Professor 1991-1993 Department of Public Health, University of Edinburgh, UK Consultant 1999-2001 Cancer Research Institute, University of California San Francisco (UCSF) Associate Specialist 2001-2002 Cancer Research Institute, UCSF Specialist 2002-2008 Cancer Research Institute, UCSF Associate Researcher 2007-2008 Department of Epidemiology and Biostatistics, UCSF Assistant Adjunct Professor 2008-2015 Life Sciences Division, Lawrence Berkeley National Laboratory (LBNL) Geneticist Staff Scientist 2015-2017 Biological Systems and Engineering Division, LBNL Geneticist Staff Scientist 2017-now Biological Systems and Engineering Division, LBNL Geneticist Senior Scientist 2016-now Berkeley Biomedical Data Science Center (BBDS), LBNL co-Director 2018-now Comparative Biochemistry Program, University of California Berkeley Adjunct Professor HONORS AND AWARDS: 1983-86 Outstanding student award, Southeast University 1988 Outstanding postgraduate student award, Beijing Medical University 1990 Outstanding teacher award, Beijing Medical University 1993-1996 Postgraduate Scholarship, University of Glasgow 1993-1996 Oversea Research Student Award, Committee of Vice-Chancellor and Principals of the Universities of the United Kingdom 1995 Travel fellowship, Glasgow University 2001-2004 Special Fellowship, the Leukemia and Lymphoma Society of America 2007 UCSF the Research Evaluation and Allocation Committee (REAC) Award 2017 LBNL Recognition Award for exceptional effort and leadership for new program development 2018 The 2018 Director's Award for Exceptional Achievement in Societal Impact. OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS: 2012- Epigenetics Society 2009- Radiation Research Society 2006- Society of Chinese Bioscientists in America 1999- American Association for Cancer Research 1993- British Association for Cancer Research 2017- AAAS 2013-17 Editorial Board: Dataset Papers in Science; New Journal of Science 2014-16 Editorial Board: Molecular Cytogenetics 2014- Academic Editor: PLoS ONE 2015- Editorial Board: Scientific Reports; Insights in Cancer Research; Advances in Modern Oncology Research PUBLICATIONS: (total 142 research and 19 review articles; H-index=40) Peer-reviewed Research Articles: Cameron DA, Leonard RCF, Mao JH, Prescott RJ. Identification of prognostic groups in follicular lymphoma. Leuk Lymphoma, 10:8999 (1993). Leonard RCF, Prescott RJ, Mao JH, White JM. Successful application of a previously derived prognostic index in the analysis of randomised trial of 287 patients with high grade NonHodgkin's lymphoma. Ann Oncol, 4:853856 (1993). Ross WB, Leaver HA, Yap PL, Raab GM, Su BH, Carter DC, Mao JH, Qian W, Prescott RJ. Macrophage prostaglandinE(2) and oxidative responses to endotoxin during immunosuppression associated with anesthesia and transfusion. Prostaglandins Leukot Essent Fatty Acids, 49:945953 (1993). Steel JM, Johnstone FD, Hume R, Mao JH. Insulin requirements during pregnancy in women with type I diabetes. Obstet Gynecol, 83: 253258 (1994). McMillan A, Pakianathan M, Mao JH, MaCintyre CCA. Urethral stricture and urethritis in men in scotland. Genitourin Med, 70:403405 (1994). Campbell IA, Colman SB, Mao JH, Prescott RJ, Weston CFM. An open, prospective comparison of 2 agonists given via nebuliser, nebuhaler, or pressurised inhaler by ambulance crew as emergency. Thorax, 50:7980 (1995). Mao JH, Wheldon TE. A stochastic model for multistage tumorigenesis in developing and adult mice. Math Biosci, 129:95110 (1995). Johnstone FD, Prescott RJ, Steel JS, Mao JH, Chambers S, Muir N. Clinical and ultrasound prediction of macrosomia in diabetic pregnancy. Br J Obstet Gynaecol, 103:747754 (1996). Ellard GA, Johnstone FD, Prescott RJ, Wang JX, Mao JH. Smoking during pregnancy: the dose dependence of birthweight deficits. Br J Obstet Gynaecol, 103:806813 (1996). Wheldon EG, Lindsay KA, Wheldon TE, Mao JH. A twostage model for childhood acute lymphoblastic leukaemia: application to hereditary and nonhereditary leukaemogenesis. Math Biosci, 139:1-24 (1997). Mao JH, Lindsay KA, Balmain A, Wheldon TE. Stochastic modeling of tumorigenesis in p53 deficient mice. Br J Cancer, 77:243-52 (1998). Nibbs RJ, Yang J, Landau NR, Mao JH, Graham GJ. LD78, A non-allelic variant of human MIP-1 (LD78), has enhanced receptor interactions and potent HIV suppressive activity. J Biol Chem, 274:17478-83 (1999). Nagase H, Mao JH, Balmain A. A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc Natl Acad Sci USA, 96:15032-37 (1999). Paxton JR, Bolger BS, Armour A, Symonds RP, Mao JH, Burnett RA. Apoptosis in cervical squamous carcinoma: predictive value for survival following radiotherapy. J Clin Pathol, 53:197-200 (2000). Symonds P, Bolger B, Hole D, Mao JH, Cooke T. Advanced-stage cervix cancer: rapid tumour growth rather than late diagnosis. Br J Cancer, 83:566-568 (2000). Johnstone FD, Mao JH, Steel JM, Prescott RJ, Hume R. Factors affecting fetal weight distribution in women with type I diabetes. Br J Obstet Gynaecol, 107:1001-6 (2000). Nagase H, Mao JH, de Koning JP, Minami T, Balmain A. Epistatic Interactions between Skin Tumor Modifier Loci in Interspecific (spretus/musculus) Backcross Mice. Cancer Res, 61:1305-1308(2001). Mao JH, Lindsay KA, Mairs RJ, Wheldon TE. The Effect of Tissue-specific Growth Patterns of Target Stem Cells on the Spectrum of Tumours Resulting from Multistage Tumorigenesis. J Theor Biol, 210:93-100 (2001). Cai WW, Mao JH, Chow CW, Damani S, Balmain A, Bradley A. Genome-wide Detection of Chromosomal Imbalances in Tumors Using BAC Microarrays. Nat Biotechnol, 20:393-396 (2002). Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan JW, Chan F, MacCarthy-Morrogh L, Ponder B, Nagase H, Burns J, West S, Linardopoulos S, Balmain A. Identification of Aurora2/Stk6/STK15 as a candidate low penetrance tumor susceptibility gene in mouse and man. Nat Genet, 43:403-412(2003). Nagase H, Mao JH, Blamain A. Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res, 63:4849-4853 (2003). Mao JH, Wu D, Perez-Losada J, Nagase H, DelRosario R, Balmain A. Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene, 22:8379-85(2003). Mao JH, To MD, Perez-Losada J, Wu D, Del Rosario R, Balmain A. Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Genes Deve, 18:1800-5(2004). Fraga MF, Herranz M, Espada J, Ballestar E, Paz MF, Ropero S, Erkek E, Bozdogan O, Peinado H, Niveleau A, Mao JH, Balmain A, Cano A, Esteller M. A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res, 64:5527-34 (2004). Li J, Jiang T, Mao JH, Balmain A, Peterson L, Harris C, Rao PH, Havlak P, Gibbs R, Cai WW. Genomic segmental polymorphisms in inbred mouse strains. Nat Genet, 36:952-4 (2004). Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, Balmain A. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature, 432:775-9 (2004). Snijders AM, Nowak NJ, Huey B, Fridlyand J, Law S, Conroy J, Tokuyasu T, Demir K, Chiu R, Mao JH, Jain AN, Jones SJ, Balmain A, Pinkel D, Albertson DG. Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res, 15: 302-11 (2005). Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. Epigenome analyses using BAC microarrays identifies evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet, 37: 645-651 (2005). Perez-losada J, Wu D, DelRosario R, Balmain A, Mao JH. p63 and p73 do not contribute to p53 tumor suppressor activity in vivo. Oncogene, 24:5521-5524 (2005). Mao JH, Li J, Jiang T, Li Q, Wu D, Perez-Losada J, DelRosario R, Peterson L, Balmain A, Cai WW. Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene, 24:7924-34 (2005). Mao JH, Saunier EF, de Koning JP, McKinnon MM, Higgins MN, Nicklas K, Yang HT, Balmain A, Akhurst RJ. Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci USA, 103:8125-8130 (2006). To MD, Perez-Losada J, Mao JH, Hsu J, Jacks T, Balmain A. A Functional Switch From Lung Cancer Resistance to Susceptibility at the Pas1 Locus in Kras2LA2 Mice. Nat Genet, 38:926-30 (2006). Mao JH, Wu D, Perez-Losada J, Jiang T, Li Q, Neve RM, Gray JW, Cai WW, Balmain A. Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell, 11:161-73 (2007). Wakabayashi Y, Mao JH, Brown K, Girardi M, Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature, 445:761-765 (2007). de Koning JP, Wakabayashi Y, Nagase H, Mao JH, Balmain A. Convergence of congenic mapping and allele-specific alterations in tumors for the resolution of the Skts1 skin tumor susceptibility locus. Oncogene, 26:4171-4178 (2007). Wei G, Ku S, Saito S, Tang AA, Mao JH, Appella E, Balmain A, Huang EJ. HIPK2 represses -catenin-mediated Cyclin D1 Transcription: Role in Epidermal Stem Cells and Tumorigenesis. Proc Natl Acad Sci USA, 104:13040-5 (2007). Guan Y, Kuo WL, Stilwell JL, Takano H, Lapuk AV, Fridlyand J, Mao JH, Yu M, Miller ME, Santos JL, Kalloger SE, Carlson JW, Ginzinger DG, Celniker SE, Huntman DG, Gray JW. Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res, 13:5745-5755 (2007). Chiaverotti T, Couto S, Donjacour A, Mao JH, Nagase H, Cardiff RD, Cunha GR, Balmain A. Dissociation of epithelial and neuroendocrine carcinoma lineages in the tramp model of prostate cancer. Am J Pathol, 172:236246 (2008). Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science, 321:1499-1502 (2008). Mao JH*, Wu D, DelRosario R, Castellanos A, Balmain A, Perez-Losada J. Monoallelic Atm deficiency does not Increase Tumor Susceptibility to Ionizing Radiation Alone or in a P53 Heterozygous Background. Oncogene, 27:6596-6600 (2008). *corresponding author Mahler KL, Fleming J, Dworkin AM, Gladman N, Cho HY, Mao JH, Balmain A, Ewart Toland A. Sequence divergence of Mus Spretus and Mus Musculus across a skin cancer susceptibility locus. BMC Genomics, 9:626 (2008). Quigley DA, To MD, Prez-Losada J, Pelorosso FG, Mao JH, Nagase H, Ginzinger DG, Balmain A. Genetic architecture of murine skin inflammation and tumor susceptibility. Nature, 485:505-508 (2009). Hung MS, Xu Z, Lin YC, Mao JH, Yang CT, Chang PJ, Jablons DM, You L. Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library. BMC Cancer, 9:135 (2009). Li Z, Zhang Q, Mao JH, Weise A, Mrasek K, Fan X, Zhang X, Liehr T, Lu KH, Balmain A, Cai WW. An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis. Oncogene, 29:2659-71 (2010). Rocher-Ros V, Marco S, Mao JH, Gines S, Metzger D, Chambon P, Balmain A, Saura CA. Presenilin Regulates EGFR Signaling and Cell Transformation Through the Ubiquitin Ligase Fbw7. Oncogene, 29:2950-61 (2010). Hu Z, Huang G, Sadanandam A, Gu S, Lenburg ME, Pai M, Bayani N, Blakely EA, Gray JW, Mao JH. The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer. Breast Cancer Res, 12:R18 (2010). Hung MS, Lin YC, Mao JH, Xu Z, Yang CT, Jablons DM, You L. Functional polymorphism of the CK2 intronless gene plays oncogenic roles in lung cancer. PLoS ONE, 5:e11418 (2010). Climent J, Perez-Losada J, Quigley DA, Kim IJ, Delrosario R, Jen KY, Bosch A, Lluch A, Mao JH, Balmain A. Deletion of the hPER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. J Clin Oncol, 28:3770-3778 (2010). Chun MG, Mao JH, Chiu CW, Balmain A, Hanahan D. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Proc Natl Acad Sci USA, 107:17268-73 (2010). PMCID: PMC2951397 Hung MS, Mao JH, Xu Z, Yang CT, Yu JS, Harvard C, Lin YC, Bravo DT, Jablons DM, You L. Cul4A is an Oncogene in Malignant Pleural Mesothelioma. J Cell Mol Med, 15:350-358 (2011). Li T, Hung MS, Wang YC, Mao JH, Tan JL, Jahan K, Roos H, Xu Z, Jablons DM, You L. Transgenic Mice for Cre-Inducible Overexpression of the Cul4A Gene. Genesis, 49:134-41 (2011). Nguyen DH, Oketch-Rabah HA, Illa-Bochaca I, Geyer FC, Reis-Filho JS, Mao JH, Ravani SA, Zavadil J, Borowsky AD, Jerry DJ, Dunphy KA, Seo JH, Haslam S, Medina D, Barcellos-Hoff MH. Radiation acts on the microenvironment to affect Breast carcinogenesis by distinct mechanisms that decrease breast cancer latency and affect tumor type. Cancer Cell, 19:640-651 (2011). Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Deve, 25:1426-1438 (2011). To MD, Quigley DA, Mao JH, DelRosario R, Hsu J, Hodgson G, Jacks T, Balmain A. Progressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer. Mol Cancer Res, 9:1339-45 (2011). Jen KY, Song IY, Banta KL, Wu D, Mao JH, Balmain A. Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas. Blood, 119:805-9 (2012). Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility. PLoS ONE, 7:e31301 (2012). Mao JH, Wu D, Kim IJ, Kang HC, Wei G, Climent J, Kumar A, Pelorosso FG, DelRosario R, Huang EJ, Balmain A. Hipk2 cooperates with p53 to suppress -ray radiation-induced mouse thymic lymphoma. Oncogene, 31:1176 1180 (2012). Ren S#, Peng Z#, Mao JH#, Yu Y, Yin C, Gao X, Cui Z, Zhang J, Yi K, Xu W, Chen C, Wang F, Guo X, Lu J, Yang J, Wei M, Tian Z, Guan Y, Tang L, Xu C, Wang L, Gao X, Tian W, Wang J, Yang H, Wang J, Sun Y. RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene-fusions, cancer associated long noncoding RNAs. Cell Res, 22:806-21 (2012). #co-first author Choi H, Kratz J, Pham P, Lee S, Ray R, Kwon YW, Mao JH, Kang HC, Jablons D, Kim IJ. Development of a rapid and practical mutation screening assay for human lung adenocarcinoma. Int J Oncol, 40:1900-6 (2012). Kwon Y, Kim IJ, Wu D, Lu J, Stock Jr WA, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res, 10: 834-844 (2012). Zhang S, Wang Y, Mao JH, Hsieh D, Kim IJ, Hu LM, Xu Z, Long H, Jablons DM, You L. Inhibition of CK2 Down-Regulates Hedgehog/Gli Signaling Leading to a Reduction of a Stem-Like Side Population in Human Lung Cancer Cells. PLoS ONE, 7: e38996 (2012). Mulvihill MS, YW Kwon, S Lee, LT Fang, H Choi, R Ray, HC Kang, JH Mao, D Jablons, IJ Kim. Gremlin 1 is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells. PLoS ONE, 7: e42264 (2012). Wei G, Wang Y, Zhang P, Lu J, Mao JH.  HYPERLINK "http://www.omicsonline.org/1948-5956/pdfdownload.php?download=JCST-04-299.pdf%09&&aid=8066" \t "_blank" Evaluating the prognostic significance of FBXW7 expression level in human breast cancer by a meta-analysis of transcriptional profiles. J Cancer Sci Ther, 4:299-305 (2012). Li T, Hou SC, Mao JH, Wang YC, Lu XD, Tan JL, You B, Liu YP, Ni J,Au A, Jablons DM, Xu Z, You L. The Expression of Dishevelled-3 and Glutamine Metabolism in Malignant Pleural Mesothelioma. J Clin Pathol, 65: 855-8 (2012). Ren S, Xu C, Cui Z, Yu Y, Xu W, Wang F, Lu J, Wei M, Lu X, Gao X, Liang Y, Mao JH*, Sun Y*. Oncogenic CUL4A determines the response to thalidomide treatment in prostate cancer. J Mol Med (Berl), 90:1121-1132 (2012). * Co-Corresponding author Snijders AM, Marchetti F, Bhatnagar S, Duru N, Han J, Hu Z, Mao JH, Gray JW, Wyrobek AJ. Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility. PLoS ONE, 7: e45394 (2012). Okumura K, Sato M, Saito M, Miura I, Wakana S, Mao JH, Miyasaka Y, Kominami R, Wakabayashi Y. Independent genetic control of early and late stages of chemically induced skin tumors in a cross of a Japanese wild derived inbred mouse strain, MSM/Ms. Carcinogenesis, 33:2260-8 (2012). Liu Y, Ren S, Castellanos-Martin A, Perez-Losada J, Kwon YW, Huang Y, Wang Z, Abad M, Cruz-Hernandez JJ, Rodriguez CA, Sun Y, Mao JH. Multiple novel alternative splicing forms of FBXW7 have a translational modulatory function and show specific alteration in human cancer. PLoS ONE, 7: e49453 (2012). Lee DY, Bowen BP, Nguyen DH, Parsa S, Huang Y, Mao JH, Northen TR. Low-Dose Ionizing Radiation-Induced Blood Plasma Metabolic Response in a Diverse Genetic Mouse Population. Radiat Res, 178:551-555 (2012). Liu Y, Huang Y, Wang Z, Huang Y, Li X, Louie A, Wei G, Mao JH. Temporal mTOR inhibition protects Fbxw7 deficient mice from radiation induced tumor development. Aging (Albany NY), 5:111-119 (2013). Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH. Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes. Clin Cancer Res, 19: 135362 (2013). Tang H, Xiao G, Behrens C, Schiller J, Allen J, Chow CW, Suraokar M, Corvalan A, Mao JH, White M, Wistuba II, Minna JD, Xie Y. A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non-Small-Cell Lung Cancer Patients. Clin Cancer Res, 19:157786 (2013). Weier HU, Mao JH. Meta-analysis of Aurora kinase A (AURKA) expression data reveals a significant correlation between increased AURKA expression and distant metastases in human ER-positive breast cancers. J Data Mining in Genomics Proteomics, 4: 127 (2013). Louie KB, Bowen BP, McAlhany S, Huang Y, Price JC, Mao JH, Hellerstein M, Northen TR. Mass spectrometry imaging for in situ kinetic histochemistry. Scientific Reports, 3:1656 (2013). Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A. Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun, 4:1701 (2013). Kang HC, Wakabayashi Y, Jen KY, Mao JH, Zoumpourlis V, Del Rosario R, Balmain A. Ptch1 Overexpression Drives Skin Carcinogenesis and Developmental Defects in K14Ptch(FVB) Mice. J Invest Dermatol, 133:1311-20 (2013). Wang Y, Liu Y, Lu J, Zhang P, Wang Y, Xu Y, Wang Z, Mao JH*, Wei G*. Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells. Biochem Biophys Res Commun, 434: 352-356 (2013). *Co-Corresponding author Cui Z, Ren S, Lu J, Wang F, Xu W, Sun Y, Wei M, Chen J, Gao X, Xu C, Mao JH, Sun Y. The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor. Urol Oncol, 31:1117-23 (2013). Lu J, Wen M, Huang Y, He X, Wang Y, Wu Q, Li Z, Castellanos-Martin A, Abad M, Cruz-Hernandez JJ, Rodriguez CA, Prez-Losada J, Mao JH*, Wei G*.  HYPERLINK "http://www.landesbioscience.com/journals/epigenetics/article/24626/" C2ORF40 suppresses breast cancer cell proliferation and invasion through modulating expression of M phase cell cycle genes. Epigenetics, 8:571-83 (2013). *Co-Corresponding author Hung MS, Xu Z, Chen Y, Smith E, Mao JH, Hsieh D, Lin YC, Yang CT, Jablons DM, You L. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. Int J Oncol, 43:1517-22 (2013). Wang Z, Liu Y, Zhang P, Zhang W, Wang W, Curr K, Wei G, Mao JH. FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7. Oncotarget, 4:2476-2486 (2013). Wang Y, Wen M, Kwon Y, Xu Y, Liu Y, Zhang P, He X, Wang Q, Huang Y, Jen KY, LaBarge MA, You L, Kogan SC, Gray JW, Mao JH*, Wei G*. CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. Cancer Res, 74: 520-531(2014). *Co-Corresponding author Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruiz H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes SV, Barcellos-Hoff MH. Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors. Stem Cells, 32:649-61 (2014). Yang YL, Hung MS, Wang Y, Ni J, Mao JH, Hsieh D, Au A, Kumar A, Quigley D, Fang LT, Yeh CC, Xu Z, Jablons DM, You L. Lung Tumorigenesis in a Conditional Cul4A Transgenic Mouse Model. J Pathol, 233:113-23 (2014). Snijders AM, Langley S, Mao JH, Bhatnagar S, Bjornstad KA, Rosen CJ, Lo A, Huang Y, Blakely EA, Karpen GH, Bissell MJ, Wyrobek AJ. An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival. Oncotarget, 5:4011-25 (2014). Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, VanDyke T, Kwok PY, Khan J, Balmain A, Fan QW, Weiss WA.  HYPERLINK "http://www.cell.com/cell-reports/abstract/S2211-1247(14)00829-8" Expression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and the GABA-A Receptor as Therapeutic Targets in Neuroblastoma. Cell Reports, 9:1034-1046. Wang Y, Zhang P, Liu Z, Wang Q, Wen M, Wang Y, Yuan H, Mao JH, Wei G. CUL4A overexpression enhances lung tumor growth and sensitizes lung cancer cells to Erlotinib via transcriptional regulation of EGFR. Mol Cancer, 13:252 (2014). Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes SV, Demaria S, Barcellos-Hoff MH. Densely ionizing radiation acts via the microenvironment to promote aggressive Trp53 null mammary carcinomas. Cancer Res, 74:7137-48 (2014). Nguyen DH, Ouyang H, Mao JH, Hlatky L, Barcellos-Hoff MH. Distinct luminal type mammary carcinomas arise from orthotopic Trp53 null mammary transplantation of juvenile versus adult mice. Cancer Res, 74:7149-58 (2014). Tang J, Huang Y, Nguyen DH, Costes SV, Snijders AM, Mao JH. Genetic background modulates lncRNA-coordinated tissue response to low dose ionizing radiation. Int J Genomics, 2015:461038 (2015). Castellanos-Martn A, Castillo-Lluva S, del Mar Sez-Freire M, Blanco-Gmez A, Hontecillas-Prieto L, Patino-Alonso C, Galindo-Villardon P, Prez del Villar L, Martn-Seisdedos C, Isidoro-Garcia M, del Mar Abad-Hernndez M, Cruz-Hernndez JJ, Rodrguez-Snchez CA, Gonzlez-Sarmiento R, Alonso-Lpez D, de las Rivas J, Garca-Cenador B, Garca-Criado J, Lee DY, Bowen B, Reindl W, Northen T*, Mao JH*, Prez-Losada J*. Unraveling heterogeneous susceptibility and progression of erbb2-breast cancer by a systems biology approach. Genome Biology, 16:40 (2015). *Co-Corresponding author Zhang P, Lo A, Huang Y, Huang G, Liang G, Mott J, Karpen GH, Blakely EA, Bissell MJ, Barcellos-Hoff MH, Snijders AM, Mao JH. Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment. Sci Rep, 5: 8919 (2015). You B, Yang YL, Xu Z, Dai Y, Liu S, Mao JH, Tetsu O, Li H, Jablons DM,You L. Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells. Oncotarget, 6:4357-68 (2015). Hang M, Huang Y, Snijders AM, Mao JH. Genetic background influences loss of heterozygosity patterns in radiation-induced mouse thymic lymphoma. Journal of Nature and Science, 1: e96 (2015). Wang Y, Xu Z, Mao JH, Hsieh D, Au A, Jablons DM, Li H, You L. PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer. Zhongguo Fei Ai Za Zhi. 18:345-50 (2015). Wang Y, Xu Z, Mao JH, Hung MS, Hsieh D, Au A, Jablons DM, You L. Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene. Thoracic Cancer, 6:480-487 (2015). Zhan P, Wang Y, Zhao S, Liu C, Wang Y, Wen M, Mao JH, Wei G, Zhang P. FBXW7 negatively regulates ENO1 expression and function in colorectal cancer. Lab Invest, 95:995-1004 (2015). Castillo-Lluva S, Hontecillas-Prieto L, Blanco-Gmez A, Del Mar Sez-Freire M, Garca-Cenador B, Garca-Criado J, Prez-Andrs M, Orfao A, Caamero M, Mao JH, Gridley T, Castellanos-Martn A, Prez-Losada J. A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development. Oncogene, 34:4777-90 (2015). Yang YL, Ni J, Hsu PC, Mao JH, Hsieh D, Xu A, Chan G, Au A, Xu Z, Jablons DM, You L. Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma. J Cell Mol Med, 19: 2385-96 (2015). Wen M, Kwon Y, Wang Y,Mao JH*, Wei G*. Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer. Oncotarget, 6: 25226-39 (2015). *Co-Corresponding author. Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF,Mao JH, Hang B, Xia Y. Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep, 5:15512 (2015). Hung MS, Chen IC, You L, Jablons DM, Li YC,Mao JH, Xu Z, Hsieh MJ, Lin YC, Yang CT, Liu ST, Tsai YH. Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells. Oncol Rep, 34: 3187-3195 (2015). Mao JH*, Langley SA, Huang Y, Hang M, Bouchard K, Celniker SE, Brown JB, Jansson JK, Karpen GH, Snijders AM. Identification of genetic factors that modify motor performance and body weight using Collaborative Cross mice. Sci Rep, 5: 16247 (2015). *Corresponding author. Snijders AM, Liu Y, Su L, Huang Y, Mao JH. Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas. Oncotarget, 6: 44794-805 (2015). Walian PJ, Hang B, Mao JH. Prognostic significance of FAM83D gene expression across human cancer types. Oncotarget, 7: 3332-40 (2016). Han J, Fontenay GV, Wang Y,Mao JH, Chang H. Phenotypic characterization of breast invasive carcinoma via transferable tissue morphometric patterns learned from glioblastoma multiforme. Proc IEEE Int Symp Biomed Imaging, 2016:1025-1028 (2016). Dhall S, Alamat R, Castro A, Sarker AH,Mao JH, Chan A, Hang B, Martins-Green M. Tobacco Toxins Deposited on Surfaces (Third Hand Smoke) Impair Wound Healing. Clin Sci (Lond), 130:1269-84 (2016). Hung MS, Chen IC, You L, Jablons DM, Li YC, Mao JH, Xu Z, Lung JH, Yang CT, Liu ST. Knockdown of Cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells. J Cell Mol Med, 20:1295-1306 (2016). Hu Z#, Mao JH#, Curtis C#, Ge Huang G#, Gu S, Heiser L, Lenburg ME, Korkola JE, Bayani N, Samarajiwa S, Seoane JA, Dan M, Esch A, Feiler HS, Wang NJ, Hardwicke MA, Laquerre S, Jackson J, Wood K, Weber B, Spellman PT, Aparicio S, Wooster R, Caldas C, Gray JW. Genome co-amplification up-regulates a mitotic gene network whose activity predicts outcome and response to mitotic protein inhibitors in breast cancer. Breast Cancer Res, 18:70 (2016). #Co-first Author Adams CJ, Yu JS,Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. The Trp53 delta proline (Trp53P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog, 55:1387-96 (2016). Wang P, Wang Y, Hang B, Zou X, Mao JH. A novel gene expression-based prognostic scoring system to predict survival in gastric cancer. Oncotarget, 7: 55343-51(2016). Snijders AM, Mao JH. Multi-omics approach to infer cancer therapeutic targets on chromosome 20q across tumor types. Adv Mod Oncol Res, 2: 215223 (2016). Snijders AM, Mao JH. Co-expression network analysis of Fbxw7-associated lncRNAs reveals their functions in radiation-induced thymic lymphoma. Insights Cancer Res, 1: 1-5 (2016). Zhang W, Mao JH, Zhu W, Jain AK, Liu K , Brown JB, Karpen GH. Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy. Nat Commun, 7:12619 (2016). Yue Y, Leung SG, Liu Y, Huang Y, Grundt K, stvold AC, Jen KY, Schild D, Mao JH*, Wiese C*. Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice. Oncotarget, 7:61874-89 (2016). *Co-Corresponding author. Snijders AM, Langley SA, Kim YM, Brislawn CJ, Noecker C, Zink EM, Fansler SJ, Casey CP, Miller DR, Huang H, Karpen GH, Celniker SE, Brown JB, Borenstein E, Jansson JK, Metz TO, Mao JH. Influence of early life exposure, host genetics and diet on the mouse gut microbiome and metabolome. Nat Microbiol, 2:16221 (2017). Snijders AM, Lee SY, Hang B, Hao W, Bissell MJ, Mao JH. FAM83 family oncogenes are broadly involved in human cancers: An integrative multi-omics approach. Mol Oncol, 11: 167-179 (2017). Hang B, Snijders AM, Huang Y, Schick SF, Wang P, Xia Y, Havel C, Jacob III P, Benowitz N, Destaillats H, Gundel LA, Mao JH. Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice. Sci Rep, 7: 41915 (2017). Yan H, Bi L, Wang Y, Zhang X, Hou Z, Wang Q, Snijders AM, Mao JH. Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas. Sci Rep, 7: 333 (2017). Wang Y, Zhang P, Wang Y, Zhan P, Liu C, Mao JH*, Wei G*. Distinct interactions of EBP1 isoforms with FBXW7 elicit different functions in cancer. Cancer Res, 77:1983-96 (2017). *Co-Corresponding author. Wang P, Wang L, Sha J, Lou G, Lu N, Hang B, Mao JH, Zou X. Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers. Sci Rep, 7: 3015 (2017). Li C, Zhang P, Jiang A, Mao JH*, Wei G*. A short synthetic peptide fragment of human C2ORF40 has therapeutic potential in breast cancer. Oncotarget, 8: 41963-74 (2017). *Co-Corresponding author. Turker MS, Grygoryev D, Lasarev M, Ohlrich A, Rwatambuga FA, Johnson S, Dan C, Eckelmann B, Hryciw G,Mao JH, Snijders AM, Gauny S, Kronenberg A. Simulated space radiation-induced mutants in the mouse kidney display widespread genomic change. PLoS One, 12:e0180412 (2017). Caueto J, Cardeoso-lvarez E, Garca-Hernndez JL, Galindo-Villardn P, Vicente-Galindo P, Vicente-Villardn JL, Alonso-Lpez D, De Las Rivas J, Valero J, Moyano-Sez E, Fernndez-Lpez E, Mao JH, Castellanos-Martn A, Romn-Curto C, Prez-Losada J. miR-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma. Br J Dermatol, 177:168-178 (2017). Mao JH*, van Diest PJ, Perez-Losada J, Snijders AM*. Revisiting the impact of age and molecular subtype on overall survival after radiotherapy in breast cancer patients. Sci Rep, 7: 12587 (2017). *Co-Corresponding author. Bi L, Yan X, Yang Y, Qian L, Tian Y, Mao JH*, Chen W*. The component formula of Salvia Miltiorrhiza and Panax Ginseng induces apoptosis and inhibits cell invasion and migration through targeting PTEN in lung cancer cells. Oncotarget, 8:101599-101613 (2017). *Co-Corresponding author. Bouchard K, HYPERLINK "https://papers.nips.cc/author/alejandro-bujan-9535" Bujan A,Roosta-Khorasani F,Ubaru S,Prabhat M, Snijders A,Mao JH,Chang E, Mahoney MW,Bhattacharya S. Union of Intersections (UoI) for Interpretable Data Driven Discovery and Prediction. Adv Neural Inf Process Syst,30: 717 (2017). Chen EG, Wang P, Lou H, Wang Y, Yan H, Bi L, Liu L, Li B, Snijders AM*, Mao JH*, Hang B*. A robust gene expression-based prognostic risk score predicts overall survival of lung adenocarcinoma patients. Oncotarget, 9: 6862-71 (2018). *Co-Corresponding author. Hang B, Wang Y, Huang Y, Wang P, Langley SA, Bi L, Sarker AH, Schick SF, Havel C, Jacob III P, Benowitz N, Destaillats H, Tang X, Xia Y, Jen KY, Gundel LA, Mao JH*, Snijders AM*. Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice. Clin Sci (Lond), 132:475-488 (2018). *Co-Corresponding author. Furuta S, Ren G, Mao JH, Bissell MJ. Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs. eLife, 7: e26148 (2018). Chang H, Han J, Zhong C, Snijders AM,Mao JH. Unsupervised Transfer Learning via Multi-Scale Convolutional Sparse Coding for Biomedical Applications. IEEE Trans Pattern Anal Mach Intell, 40(5): 1182-94 (2018). Sez Freire MDM, Gmez AB, Lluva SC, Vecino AG, Jimnez JMG, Seisdedos CM, Garca MI, Prieto LH, Garca-Cenador MB, Garca Criado FJ, Patino Alonso MC, Villardn PG,Mao JH, Prieto C, Martn AC, Kaderali L, Perez-Losada J. The biological age linked to oxidative stress modifies breast cancer aggressiveness. Free Radic Biol Med, 120:133-146 (2018). Sez-Freire MDM, Blanco-Gmez A, Castillo-Lluva S, Gmez-Vecino A, Galvis-Jimnez JM, Martn-Seisdedos C, Isidoro-Garca M, Hontecillas-Prieto L, Garca-Cenador MB, Garca-Criado FJ, Patino-Alonso MC, Galindo-Villardn P,Mao JH, Prieto C, Castellanos-Martn A, Kaderali L, Prez-Losada J. Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness. Data Brief, 18:1172-1184 (2018). Xiao Y, Yin C, Wang Y, Lv H, Wang W, Huang Y, Perez-Losada J, Snijders AM, Mao JH*, Zhang P*. FBXW7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy. Mol Oncol, 12: 883-895 (2018). *Co-Corresponding author. Liu X, Bi L, Wang Q, Wen M, Li C, Ren Y, Jiao Q, Mao JH, Wang C, Wei G,Wang Y. miR-1204 targets VDR to promote epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene, 37:3426-3439 (2018). Chen K, Luan X, Liu Q, Wang J, Chang X, Snijders AM, Mao JH, Secombe J, Dan Z, Chen JH, Wang Z, Dong X, Qiu C, Chang X, Zhang D, Celniker SE, Liu X. The histone demethylase KDM5 regulates social interaction by maintaining gut microbiota homeostasis. Cell Host Microbe, 25(4):537-552 (2019). Zhou YX, Fuentes-Creollo G, Ponce F, Langley SA, Jen KY, Celniker SE, Mao JH, Snijders AM. No difference in 4-nitroquinoline induced tumorigenesis between germ-free and colonized mice. Mol Carcinog, 58: 627632 (2019). Hung MS, Chen YC, Lin PY, Li YC, Hsu CC, Lung JH, You L, Xu Z, Mao JH, Jablons DM, Yang CT. Cul4A modulates invasion and metastasis of lung cancer through regulation of ANXA10. Cancers (Basel), 11(5): 618 (2019). Wang P, Wang Y, Langley SA, Zhou YX, Jen KY, Sun Q, Brislawn CJ, Rojas CM, Wahl KL, Wang T, Fan X, Jansson JK, Celniker SE, Zou X, Threadgill DW, Snijders AM*, Mao JH*. Diverse tumor susceptibility in Collaborative Cross mice: Identification of a new mouse model for human gastric tumorigenesis. Gut, 68(11):1942-1952 (2019). *Co-Corresponding author Kim YM, Snijders AM, Brislawn CJ, Stratton KG, Zink EM, Fansler SJ, Metz TO, Mao JH*, Jansson JK*. Light-stress influences the structure of the murine gut microbiome, memory function, and plasma metabolome. Front. Mol Biosci. 6:108 (2019). *Co-Corresponding author Zhao Y, Yang SM, Jin YL, Xiong GW, Wang P, Snijders AM, Mao JH, Zhang XW, Hang B. A robust gene expression prognostic signature for overall survival in high-grade serous ovarian cancer. J Oncol, 2019: 3614207 (2019). Omene C, Ma L, Moore J, Ouyang H, Illa-Bochaca I, Chou W, Patel M, Sebastiano C, Demaria S, Mao JH, Karagoz K, Gatza M, Barcellos-Hoff MH. Aggressive mammary cancers lacking lymphocytic infiltration arise in irradiated mice and can be prevented by dietary intervention. Cancer Immunol Res. In press. Peer-reviewed Review Articles: Mao JH*, Balmain A. Genomic approaches to identification of tumour-susceptibility genes using mouse models. Curr Opin Genet Dev, 13: 14-9 (2003). *corresponding author de Koning JP, Mao JH, Balmain A. Novel approaches to identify low penetrance cancer susceptibility genes using mouse models. Recent Results Cancer Res, 163:19-27(2003). Perez-losada J, Mao JH, Balmain A. Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Cancer Res, 65: 6488-92 (2005). To MD, Perez-Losada J, Mao JH, Balmain A. Crosstalk between Pten and Ras signaling pathways in tumor development. Cell Cycle, 4: 1185-1188 (2005). Climent J, Mao JH, Garcia JL, Arsuaga J, Perez-Losada J. Characterization of breast cancer by array CGH. Biochemistry and Cell Biology, 85:497-508 (2007). Prez-Losada J, Castellanos-Martn A, Mao JH. Cancer Evolution and Individual Susceptibility. Integrative Biology, 3: 316-328 (2011). PMCID: PMC3125395 Xu R, Mao JH. Gene transcriptional networks integrate microenvironmental signals in human breast cancer. Integrative Biology, 3: 368-374 (2011). Barcellos-Hoff MH, Adams C, Balmain A, Costes SV, Demaria S, Illa-Bochaca I, Mao JH, Ouyang H, Sebastiano C, Tang J. Systems biology perspectives on the carcinogenic potential of radiation. J Radiat Res, 55 Suppl 1:i145-i154 (2014). Mao JH, Weier HUG. Bioinformatics applications in biological and clinical studies. J Data Mining Genomics Proteomics, 5: e114 (2014). Mao JH, Snijders AM. Low-dose radiation cancer susceptibility models. Aging (Albany NY), 7: 352-353 (2015). Mao JH, Weier HUG. In the Race towards a Better Diagnosis and Prognostication of Cancer Patients Long Non-Coding Intergenic RNAs (lincrnas) have found their Place. J Data Mining Genomics Proteomics, 6: e120 (2015). Suter B, Zhang X, Pesce CG, Mendelsohn AR, Dinesh-Kumar SP, Mao JH. Next-Generation Sequencing for Binary ProteinProtein Interactions. Front Genet, 6: 346 (2015). Barcellos-Hoff MH, Mao JH. HZe radiation non-targeted effects on the Microenvironment that Mediate Mammary Carcinogenesis. Front Oncol, 6:57 (2016). Blanco-Gmez A, Castillo-Lluva S, Del Mar Sez-Freire M, Hontecillas-Prieto L, Mao JH, Castellanos-Martn A, Prez-Losada J. Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes. BioEssays, 38:664-73 (2016). Peyton Jacob III, P, Benowitz NL, Destaillats H, Gundel L, Hang B, Martins-Green M, Matt GE, Quintana PJE, Samet JM, Schick SF, Talbot P, Aquilina NJ, Hovell MF, Mao JH, Whitehead TP.  HYPERLINK "https://www.researchgate.net/publication/311247774_Thirdhand_Smoke_New_Evidence_Challenges_and_Future_Directions?ev=prf_pub" Thirdhand Smoke: New Evidence, Challenges, and Future Directions. Chem Res Toxicol, 30: 270"294 (2017). Hang B, Wang P, Zhao Y, Sarker A, Chenna A, Xia Y, Snijders AM,Mao JH. Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models. Int J Mol Sci, 18: E932 (2017). Hang B,Mao JH, Snijders AM. Genetic Susceptibility to Thirdhand Smoke induced Lung Cancer Development. Nicotine Tob Res, 21(9):1294-1296 (2019). Hang B, Wang P, Zhao Y, Chang H, Mao JH, Antoine M. Snijders AM. Thirdhand Smoke: Genotoxicity and Carcinogenic Potential. Chronic Diseases and Translational Medicine in press. Zargar A, Chang S, Kothari A, Snijders AM, Mao JH, Wang J, Hernndez AC, Keasling JD, Bivona TG. Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy. Chronic Diseases and Translational Medicine in press. Chapters in books: Mao JH and Wheldon TE. Multistage models for radiation tumorigenesis in p53 deficient transgenic mice: computer simulation of the effect of single doses of radiation. In: `Advances in Mathematical Population Dynamics: Molecules, Cells and Man', edited by Arino O., Axelrod D. and Kimmel M., London: World Scientific. pp241-253. Nagase H, Frame S, Mao JH, Balmain A. Genetic control of tumor predisposition and progression in mice. In New Frontiers in Mechanistic Cancer Research in Animal Models (eds Cohen S, Hino O, Ishikawa T, Nakagama H, Shirai T, Sugimura T), Princess Takamatsu Cancer Research Fund, Tokyo, 22-26 (1999). PATENT AND DISCLOSURES: Issued patents: Jian-Hua Mao and Allan Balmain. Loss of FBXW7 is a Biomarker of Sensitivity to Treatment of Tumors with Inhibitors of mTOR. Patent#: WO2010030865. Zhi Hu, Jian-hua Mao, Wen-Lin Kuo, Ge Huang, and Joe W. Gray. Cancer Specific Mitotic Network. Patent#: USA20120222139. Weiguo Zhang, Jian-Hua Mao, Gary H Karpen. Use of centromere / kinetochore protein genes for cancer prognosis, diagnosis and treatment. Patent#: USA2015031413 and WO201517931 2. Patent applications: Antoine Snijders, Jian-Hua Mao, Sasha Langley, Thomas Metz, and Janet Jansson. Specific microbes affect host behavior, possibly through memory enhancement or fear I pain reduction. Patent#: 62/447,417. Antoine Snijders and Jian-Hua Mao. Gene signatures that predict survival benefit from radiotherapy in luminal A and basal type breast cancer patients. Patent#: 62/487,759 Invention disclosures: Mao JH, Perez-Losada J, and Balmain A. Derivation of a mouse model for the generation of multiple epithelial tumor types. UCSF Disclosure#: SF2004-100 (2004). Li Z, Mao JH, Balmain A, and Cai WW. A novel gene with tumor suppressing activity. UCSF Disclosure#: SF2006-050 (2006). Yongwon Kwon and Jian-Hua Mao. A novel vectors, pFN-HA and pFC-HA for Tandem Affinity purification (TAP). LBNL Disclosure#: IB-3100 (2011). Yongwon Kwon and Jian-Hua Mao. UBE2T, DTL, and NUF2 are a novel biomarker for cancer diagnosis, prognosis and therapy. LBNL Disclosure#: IB-3091 (2011). Zeran Wang, Yueyong Liu, and Jian-Hua Mao. FAM83D is a novel biomarker for human cancer prognosis and potential therapeutical target. LBNL Disclosure#: 2013-027 (2012). H.-Ulrich Weier, Jian-Hua Mao, A. A. Polyzos. Aurora Kinase A (AURKA) as antimitotic chemotherapy target in thyroid cancer. LBNL Disclosure#: 2013-131. Antoine Snijders, Pin Wang, Bo Hang and Jian-Hua Mao. A novel 27-gene prognostic signature for lung cancer survival. LBNL Disclosure#: 2017-082. RESEARCH SUPPORT: Ongoing Research Support 239523 Jansson, Janet (PI) 08/15/14-09/30/19 Pacific Northwest National Laboratory Subk/Prime: Office of Naval Research 102662 Influence of Gut Microbiome-Host Interactions on Stress Induced by Altered Sleep Patterns. The goal of this project is to study host-intestinal microbial interactions in response to specific stressors, with a long-term goal of identifying new strategies to increase warfighter resilience to stress resulting in reductions in infection, traumatic injuries and enhanced performance. Specifically, this project utilizes diverse murine models to identify whether stress induced by altered sleep cycles experienced by personnel on submarines affects the composition of the gut microbiome, potentially resulting in altered motor function and anxiety. Role: Co-Investigator CRADA Karpen, Gary (PI) 10/01/15-4/30/19 DOE/LBNL-Jiangsu Nanjing High Tech Zone FAM83A and D of a newly discovered family of oncogenes are promising therapeutic targets in human cancers This cooperative research and development agreement (CRADA) is established for translational studies on the genes that are significantly altered in transition from pre-invasive to invasive phenotype, such as FAM83A and FAM83D, in breast cancer progression. Role: Project co-Leader NNJ16HP22I Blakely, Ellie (PI) 02/04/16-02/03/20 NASA Simulation of GCR-induced Harderian Gland and lung tumorigenesis The project specifically proposes the completion of experiments that measure LET-sensitive tumors to rest the hypotheses, based on existing experimental data with one-component (single-ion) exposure, on how tumor prevalence may change in response to a multi-component (mixed field) GCR exposure. The proposed studies will use a well characterized animal model with low spontaneous tumor prevalence that allows us to test very low doses relevant to the human experience in space, supporting the extrapolation of simulator experimental exposure schemes to space relevant particles influences. Role: Co-I R01 CA064786 Bissell, Mina (PI) 08/01/16-07/31/21 NIH/NCI Definition of the microenvironment in Breast Cancer This project focuses on understanding the reciprocal communication between Ln1 outside the cell and gene expression by investigating two key nuclear factors: nuclear actin and p53, which serve as essential signaling nodes to achieve normal tissue function. Role: Co-I DE-AC02-05CH11231 Mao, Jian-Hua (PI) 10/01/16-9/30/18 LDRD (Laboratory Directed Research and Development)/DOE 103083 Impact of gut microbiome on genetic susceptibility to chemically induced colon cancer The gut microbiome is known to play important roles in host physiology, health and disease. The goal of this project is to exploit the power of mouse genetics, together with Omics analyses to determine the influence of individual variations in gut microbiome on disease susceptibility. Role: PI R56 AG056505 Beilicki, John (PI) 09/25/17-08/31/18 NIH/NIA 105505 ApoE2, aging, and preservation of ABC transporter function This project will identify biological processes that are associated with exceptional longevi#$&'03NOWXth[NA[4[hMh6DOJQJaJhMhHOJQJaJhMh!XOJQJaJhMhPOJQJaJh6DCJOJQJaJh6Dh6D5CJOJQJaJhYCJOJQJaJhMhYOJQJaJh6DhY5CJOJQJh5CJOJQJhY5CJOJQJhYhY5CJOJQJhMh9OJQJaJhCJOJQJh}5CJOJQJh{h}CJOJQJaJO. / :  m  P Q j   ! ` gdg  !gdC  !`gdDW]gd6D$`5$9D^``a$gd6D $5$9Da$gd!XF]^F`gdYxgdZT   , - . / : ? D 淩|rfaTGh{h=.+OJQJaJh{h]OJQJaJ h}>*hQhQ>*CJaJh}CJOJQJhMh_N0JOJQJaJhMh_NOJQJaJ!jhMh_NOJQJUaJh6Dh}5CJOJQJhCJOJQJh6DCJOJQJh6DhP5CJOJQJhMh}OJQJaJhMhPOJQJaJhMh6DOJQJaJD F G    . [ \ ] f l m r v w z {   O P Q ٤ϊ}s}}}dhQh}5>*CJ\aJhDWOJQJaJh{h9OJQJaJh{htOJQJaJh{h#OJQJaJh{h=.+OJQJaJ!h{h}B*OJQJaJphh{hj OJQJaJhCOJQJaJh{h]OJQJaJh{hUlOJQJaJh{h}OJQJaJ'Q h i j o q t ( ) 4 5 ? P Y Z t ̿濱̿濿̿旿̿}濊h{h=OJQJaJh{hJOJQJaJh{h~HOOJQJaJh{hgOJQJaJh{h 5OJQJaJh{hQOJQJaJh{hOJQJaJh{h}OJQJaJh{h OJQJaJ h}5CJ h}5-j ) P 5 V %a| ^`gd  !`gd ^`gdg  ! ` gdg !^`gdg  !`gdDW     0 4 5 @ A U V [ _ ` ̿}̿pbTbFb}h{h85OJQJaJh{h}5OJQJaJh{hJ5OJQJaJh{h}OJQJaJh{hPOJQJaJh{h OJQJaJh{h 5OJQJaJh{hgOJQJaJh{h=OJQJaJh{hQOJQJaJh{hOJQJaJh{hOJQJaJh{h8OJQJaJh{hJOJQJaJ   $%.\`aqr|̿{nn`RE7h{h 5OJQJaJh{h OJQJaJh{hV5OJQJaJh{hpn5OJQJaJh{hVOJQJaJh{hZxOJQJaJh{h}OJQJaJh{heU5OJQJaJh{hP5OJQJaJh{hQM5OJQJaJh{hJOJQJaJh{h=OJQJaJh{hPOJQJaJh{hOJQJaJh{hpnOJQJaJ  'Ijk|}~~pd_ZPC6h{hOJQJaJh{h~HOOJQJaJhC OJQJaJ h}>* h~HO>*hQh`>*CJaJh{hW%5OJQJaJ5h{hW%5B*OJQJaJfHph"""q 2h{hW%B*OJQJaJfHph"""q h{hW%OJQJaJh{h95OJQJaJh{h=OJQJaJh{h9OJQJ\aJh{h9OJQJaJhJbpOJQJaJk}~PQE & F $^a$gdDW ]`gdDW`]^``gdj ^`gdg`gdDW ^`gd9 ^`gdDW35P[su.@DPQ\o̿ٲً̿t_)h{hOJQJaJfHq h{hOJQJaJhDWOJQJaJh{h]OJQJaJh{hOJQJaJh{h}OJQJaJh{hKhOJQJaJh{hOOJQJaJh{hOJQJaJh{h~HOOJQJaJh{h3OJQJaJh{hgOJQJaJ$DEIJKSu^Du7h{h}OJQJaJ2h{hB*OJQJaJfHph"""q ,hDWB*OJQJaJfHph"""q 2h{hUvB*OJQJaJfHph"""q h{hUvOJQJaJh{hlOJQJaJhDWOJQJaJh{hLOJQJaJh{hOJQJaJ)h{hOJQJaJfHq 9h{h0J656OJQJ\]aJfHq  5:<ejlƵƤƓyyyhhWIWhC B*OJQJaJph!h{h~ B*OJQJaJph!h{h}B*OJQJaJphh{h}OJQJaJh{hn'OJQJaJ!h{hNB*OJQJaJph!h{hr#B*OJQJaJph!h{hn'B*OJQJaJph!h{h"B*OJQJaJphh&OJQJaJh&h&OJQJaJ"hQh}5;CJOJQJaJ5e?0 & F ^`gdDWgdgd:M h^hgd0 & F`gdDW$^`a$gd&56>?FVWijkұұҠҌuauL)h{hCOJQJaJfHq 'h{hC0JA6OJQJaJmH sH h{hCOJQJaJhCOJQJaJ'h{h&0JA6OJQJaJmH sH !h{h&B*OJQJaJph'h{h&0J66OJQJaJmH sH h{hzOJQJaJh{h&OJQJaJhzOJQJaJh{hbOJQJaJh OJQJaJ 067żŬzm_Rmh{h3FOJQJaJh{h}5OJQJaJh{h}OJQJaJhh5'>*aJ h$>*aJ hdapaJ h[ aJh6h}aJhQh}>*CJaJ h:M>*CJh>*CJaJh >*CJaJh&>*CJaJ h&>*CJ hd>*CJ h >*CJ h >*CJ h}>*CJhQhZxCJOJQJaJilrvb 0̿z̿̿[<hVhV0J)56B*OJQJaJfHphq hV56OJQJaJh{h}56OJQJaJh{hJ]AOJQJaJh{h3FOJQJaJh{h}5OJQJaJh{h}OJQJaJhVOJQJaJhVh}OJQJaJ8hVhV56B*OJQJaJfHphq #0KQRy  9?KLEY_o󻱤󔱤󻱱h{h OJQJaJh{h}56OJQJaJh{hFOJQJaJhVOJQJaJ8hVhV56B*OJQJaJfHphq h{h3FOJQJaJh{h}5OJQJaJh{h}OJQJaJ5olx* !1""#q$%]&''()U*a+v,--./}0 & F ^`gdDW0FRZ\lx:>BPbx.0<>wj]]]jh{h MOJQJaJh{hFOJQJaJh{h}56OJQJaJh{hluV56OJQJaJhV56OJQJaJh{h3FOJQJaJh{h}5OJQJaJh{h OJQJaJhVOJQJaJ8hVhV56B*OJQJaJfHphq h{h}OJQJaJ,8P   ) * V \ i ! !!!h!s!x!!!!!!"""1";"ķĆķ뷧|뷷_8hVh' R56B*OJQJaJfHphq h' ROJQJaJ'h{h}56B*OJQJaJphh{hFOJQJaJh{h}56OJQJaJh{h}OJQJaJ!h{h}B*OJQJaJph+h{h}0J5>*B*OJQJaJph(h{h}0J>*B*OJQJaJph%;"A"f""""""""""#########$N$Q$Z$\$a$q$$$$$$$%% % %%0%{%%%䔲zzzzlh{h}6OJQJaJh{h3FOJQJaJh{h9OJQJaJh{hw56OJQJaJh{h}OJQJ\aJh{h}56OJQJaJ"h{h}0J 56OJQJaJh{h}0J 5OJQJaJh{h}OJQJaJh{h}5OJQJaJ*%%%%%%%&<&F&]&c&&&&&&''''''''(*(0((((((()7)8)q)z))))))))*;*A*B*U******+B+L+a++++h{hb2+OJQJaJh{hw56OJQJaJh{h}56OJQJaJh{h}6OJQJaJh{h3FOJQJaJh{h}5OJQJaJh{h}OJQJaJ>+,W,`,a,v,,,,,,,,,----k-l------.>.?.`.f..........ra!h{h}56OJQJ\aJh{h}5OJQJ\aJh{h}OJQJ\aJh{h}6OJQJaJh{hS&OJQJaJh{h}56OJQJaJh{h3FOJQJaJh{h}5OJQJaJh{hb2+OJQJaJh{hw56OJQJaJh{h}OJQJaJ&.../^/c/l/q/t/u/{////////0]0h0i0j0z0{0|0}000ǹ󩜎~qdVHVh{hD5OJQJaJh{h}OJQJ\aJh{hOJQJaJh{h<{OJQJaJh{h}56OJQJaJh{hb2+5OJQJaJh{hb2+OJQJaJh{hw56OJQJaJh{h}H*OJQJaJh{h}6H*OJQJaJh{h}6OJQJaJh{h}5OJQJaJh{h}OJQJaJ00011111!1#15171^1d1111122 2 2,2.262񼯢yk[[NyAh{hz[OJQJaJh{h<{OJQJaJh{h 56OJQJaJh{h 6OJQJaJh{h 5OJQJaJh{h OJQJaJh{h}5OJQJaJh{h6OJQJaJh{hb2+OJQJaJh{hb2+56OJQJaJ&h{h}6OJQJ]aJmH sH h{h}OJQJaJmH sH h{h}OJQJ\aJ}071623"56678L9::;<>K@&AABC EEFCGH & F 5$9D^`gdDW & F ^`gdDW62t222222333333484>4444445 5 5 5"5G5M5z5ǺǩNJyk]PP]Ph{hUOJQJaJh{hU5OJQJaJh{h"OJQJ\aJ!h{hF6OJQJ\]aJh{hF5OJQJaJ!h{hF56OJQJ\aJ!h{hb2+56OJQJ\aJh{h MOJQJaJh{hFOJQJaJh{hM:OJQJaJh{hF5OJQJ\aJh{hFOJQJ\aJz55555556666 6 66666 6"6)6-676;6B6D6Y6m66666®xxxxxxxxh[h{h"OJQJaJh{hAm56OJQJaJh{hfFOJQJaJh{hAm5OJQJaJh{hfF5OJQJaJh{hAmOJQJaJ&h{hJOJQJ\]aJnHtHh{h!]5OJQJ\aJ!h{hw56OJQJ\aJh{h!]OJQJ\aJh{hUOJQJ\aJ6666666666666666667 7 77d7g7777777ʹʹʨʹʗt`OO h{h_OJQJaJmH sH &h{h56OJQJaJmH sH  h{h9OJQJaJmH sH #h{h6OJQJaJmH sH  h{hOJQJaJmH sH  h{hOJQJaJmH sH h{h9OJQJaJmH sH h{hOJQJaJmH sH #h{h&'5OJQJaJmH sH #h{h5OJQJaJmH sH 7777778%80858A8m8q8y8z8{888888909697989C9D9I9չչեyyyhZJZyZh{h%D_5OJQJ\aJh{h%D_OJQJ\aJ!h{hI]756OJQJ\aJh{hI]7OJQJ\aJh{hI]75OJQJaJh{hz[56OJQJaJ'h{hz[56B*OJQJaJphh{hz[6OJQJaJh{hz[5OJQJaJh{hz[OJQJaJh{hI]7OJQJaJ h{h$OJQJaJmH sH I9K9L9c9i999:::: :&:e:f:n::::::ֵ֨r`QB5h{h$OJQJaJh{h+0J(OJQJaJh{h'F0J(OJQJaJ"h{h+0J)56OJQJaJh{h+OJQJ\aJh{hC^OJQJaJh{h+5OJQJaJh{h+OJQJaJh{h=OJQJaJ!h{h%D_56OJQJ\aJh{h%D_5OJQJ\aJh{h%D_OJQJ\aJh{hu!OJQJaJh{hI]7OJQJ\aJ:::::;;9;:;;;;;;;;;;;ٺ~obTF6h{hS&5OJQJ\aJh{hS&OJQJ\aJh{h/^5OJQJaJh{h$OJQJaJh{h=20J(OJQJaJh{h'F0J(OJQJaJ"h{h=20J)56OJQJaJh{hC^OJQJaJh{hC^5OJQJaJ h{hC^OJQJaJmH sH h{h=25OJQJaJh{h=2OJQJaJh{h+OJQJaJh{h'FOJQJaJ;;;;<< <<<<,<1<<<<<<<<<<غzk[kzL>h{hW"5OJQJaJh{hw0J*OJQJaJh{h=20J*OJQJ\aJh{h=20J*OJQJaJh{h'F0J*OJQJaJ%h{h=20J*56OJQJ]aJh{hS&6OJQJ\aJh{hS&OJQJ\aJh{hS&5OJQJaJh{hS&5OJQJ]aJh{hS&OJQJ]aJh{h OJQJaJh{hS&OJQJaJ<<<<<<<<<<<=.>0>D>F>N>>>>>>>>>隇q[q[Lh{hJ0J(OJQJaJ*h{h456OJPJQJaJnHtH*h{h'F56OJPJQJaJnHtH$h{h'FOJPJQJaJnHtHh{h'FOJQJaJ$h{h'FB*OJQJ\aJph/h{h'F5B*OJQJ\aJnHphtH,h{hvIB*OJQJ\aJnHphtH,h{h'FB*OJQJ\aJnHphtH>>J?Z?|???????@&@'@(@4@5@6@D@H@J@K@T@仭ɌpaQDh{h OJQJaJh{h0M0J(5OJQJaJh{hmk20J(OJQJaJh{hJ0J(OJQJaJh{hmk2OJQJaJh{hw56OJQJaJ!h{h/I6OJQJ\]aJh{h/IOJQJ\aJh{h=2OJQJ\aJh{h=25OJQJaJh{h/IOJQJaJh{h=2OJQJaJh{h'F5OJQJaJT@Z@{@@@@@A AAA%A&A/A5AAAAAAĵ|n|]L]>h{hEOJQJ\aJ!h{h[@56OJQJ\aJ!h{hE56OJQJ\aJh{hE5OJQJaJh{hEOJQJaJh{h 0J(5OJQJaJh{h0MOJQJaJh{hd0J(OJQJaJh{h 0J(OJQJaJ"h{h 0J)56OJQJaJh{h OJQJ\aJh{h OJQJaJh{h 5OJQJaJAAAAAAAB(BnBuBwBBBBBBC>CCCCCCƸƩƈ{m{{{_N@_@h{hFOJQJ\aJ!h{hy=56OJQJ\aJh{hy=OJQJ\aJh{hy=5OJQJaJh{hy=OJQJaJh{h0MOJPJQJaJ"h{hyM56OJPJQJaJh{hyMOJPJQJaJh{hyM5OJQJaJh{hyMOJQJaJh{hE0J(OJQJaJh{hEOJQJ]aJh{hE5OJQJ\aJCCCDDDDDDDDDEE E E E EEƷzaH0h{h_E0J/B*OJQJ]aJmH ph"""sH 0h{h_E0J.B*OJQJ]aJmH ph"""sH h{h_EOJQJaJh{hw56OJQJaJh{hQ56OJQJaJh{hQhyOJQJaJh{hQOJPJQJaJh{hQh;@3OJQJaJh{hQ5OJQJaJh{hQOJQJaJh{hg>OJPJQJaJEEEEE E3E9EEEEEEEEFFFFε~p`QDDD6Dh{h05OJQJaJh{h0OJQJaJh{h_gOJPJQJaJh{h_g56OJQJaJh{h_gH*OJQJaJh{h_g5OJQJaJh{h_gOJQJaJh{hQOJPJQJaJh{hQOJQJaJ0h{h_E0J1B*OJQJ]aJmH ph"""sH 0h{h_E0J/B*OJQJ]aJmH ph"""sH 0h{h_E0J0B*OJQJ]aJmH ph"""sH FqFvF{FFFFFFFFFFFG&G(G0GAGBGCGƹƪviiiZJi:Zh{h45OJPJQJaJh{h456OJQJaJh{h4OJPJQJaJh{h4OJQJaJ#h{h45OJQJaJmHsH h{h3FOJQJaJmHsH h{h4OJQJaJmHsHh{h0OJPJQJaJh{hpIOJQJaJh{h0OJQJaJh{h)<OJQJaJ!h{h056OJQJ\aJh{h0OJQJ\aJCGIGGGGGGGGH^HnHpHrHxHHHHHHHHHH䢕䕈yl^l^lNh{h@7d5OJQJ\aJh{h@7dH*OJQJaJh{h@7dOJQJaJh{hDOJPJQJaJh{h*=fOJQJaJh{hI4OJQJaJh{hg>56OJQJaJh{h rOJQJaJh{hg>6OJQJaJ,h{hg>B*OJQJ\aJnHphtHh{hg>OJQJaJh{hg>5OJQJaJHHJJJJJJJJJKKKK}K~KKKKLLLңwewVVGh{h3FOJPJQJaJh{h3OJPJQJaJ"h{hI40J)56OJQJaJh{hI4OJPJQJaJh{h3FOJQJaJh{hI45OJQJ\aJh{hI4OJQJaJh{h@7dH*OJPJQJaJ"h{h@7d56OJPJQJaJh{h@7dOJPJQJaJh{h@7dOJQJaJ!h{h@7d5H*OJQJ\aJHJKLBOPQRSTUWXZ5\D]E^^_`abcd@ee)gCh & F 5$9D^`gdDWLLLLLLLLLLLLM OOO@OBOTOZOOóӖygUH;Hh{h$3JOJQJaJh{h'fOJQJaJ"h{hKO"0J)56OJQJaJ"h{h60J)56OJQJaJh{h65OJQJ\aJh{h6OJQJaJh{h6OJPJQJaJh{hM5OJQJaJh{h`56OJQJaJh{h*56OJQJaJh{h3OJQJaJh{h3OJPJQJaJh{h35OJPJQJaJOOOOPoPwPxPPPPPPPPQ&Q'QcQeQQQQQQQQQQǺ䫞אrrbRbh{h[@56OJQJaJh{h{:56OJQJaJh{hO@OJQJaJ!jh{h{:OJQJUaJh{h{:5OJQJaJh{h{:OJQJaJh{h{:OJPJQJaJh{hKO"OJQJaJh{h'f56OJQJaJh{h%&OJQJaJh{h'fOJQJaJh{h'f5OJQJaJQQQQQR5RRRRRRRRRRRRRRSSS SSSTSUScSųŦŕvveT h{h$OJQJaJnHtH h{hBgOJQJaJnHtH#h{h75OJQJaJnHtHh{h7OJQJaJ h{h7OJQJaJnHtHh{heOJQJaJ"h{hw56OJPJQJaJh{hfOJPJQJaJ h{hfOJQJaJnHtHh{hf5OJQJaJh{hfOJQJaJcSeSuSvSSSSSSSTTTTTTTTTUUķ~l_RBRRh{h_-5OJQJ\aJh{h_-OJQJaJh{hgxOJQJaJ"h{hKO"0J)56OJQJaJh{hKO"5OJQJ\aJh{hKO"OJQJaJh{hKO"OJPJQJaJh{hH%OJQJaJh{h$OJQJaJh{h7OJQJaJh{h75OJQJaJ"h{h70J)56OJQJaJh{h7OJPJQJaJUUUUUUUUUUVVVVVVWWWWWWWX&XǸԪԚԌ|naREEh{hpOJQJaJh{h4c0OJPJQJaJh{hgxOJQJaJh{hI<5OJQJaJh{h4c056OJQJaJh{h4c05OJQJaJh{h4c00J 5OJQJaJh{h4c0H*OJQJaJh{hOJPJQJaJh{h_-OJQJaJh{h4c0OJQJaJh{hI<OJQJaJ"h{h_-0J)56OJQJaJ&X,XXXXXXXXXXXYY+YZZtZZZZ㷨||ll\OBh{h#OJQJaJh{hI<OJQJaJh{h;56OJQJaJh{h;OJQJ\^JaJh{h?y5OJQJ\aJh{h?yOJQJ\aJh{h;OJQJ\aJh{h @]OJPJQJaJh{h?OJQJaJh{hluVOJQJaJ"h{hp0J)56OJQJaJh{hpOJQJaJh{hp5OJQJ\aJZZZ&[2[\\\ \!\.\4\5\\\] ]/]0]1]C]D]N]׵ח׈{k{{Y{H9h{hI?OJPJQJaJ h{hI?OJQJaJnHtH"h{hI?0J)56OJQJaJh{hI?5OJQJ\aJh{hI?OJQJaJh{hQOJPJQJaJ h{hQOJQJaJnHtHh{hI<OJQJaJ"h{hQ0J)56OJQJaJh{hQ5OJQJ\aJh{hQOJQJaJh{hOJPJQJaJh{h;OJQJaJN]T]V]v]x]}]]]^^^)^4^5^6^<^=^D^E^x^~^^^^ƶ}p`pN<"h{h((h0J)56OJQJaJ"h{h!z0J)56OJQJaJh{h!z5OJQJ\aJh{h!zOJQJaJh{hI<OJPJQJaJh{h9OJQJaJh{hPzOJQJaJh{hI<56OJQJaJh{hw56OJQJaJ!h{hI<B*OJQJaJph"""h{hkOJQJaJh{hI<OJQJaJh{hI<5OJQJaJ^^^^^^_A_G________```}`rcVHVV:Vh{h8ROJQJ\aJh{h8R5OJQJaJh{h8ROJQJaJh{hPY8OJPJQJaJh{hPz0J)5OJQJaJ"h{hPY80J)56OJQJaJh{hPY85OJQJ\aJh{hPY8OJQJaJh{h!zOJPJQJaJh{h!zOJQJaJh{hPz0J)OJQJaJ"h{h((h0J)56OJQJaJ"h{h!z0J)56OJQJaJ}````````````awaaaaaaaƷ{iYL?Lh{h9OJQJaJh{h jnOJQJaJh{hPz0J)5OJQJaJ"h{h.?(0J)56OJQJaJh{h$OJPJQJaJh{hYukOJQJ\aJh{hYuk5OJQJ\aJh{hYukOJPJQJaJh{h8ROJPJQJaJh{h8ROJQJaJh{h8R5OJQJaJh{h^ROJQJaJ"h{h8R0J)56OJQJaJaaaabb bbbbbbbbbcJcQcYcZc\cʺʫʙ|iXXFX5X h{h$OJQJaJmH sH #h{h^R5OJQJaJmH sH h{h^ROJQJaJmH sH $h{hWLOJPJQJaJmH sH h{hMQvOJQJaJh{hPz0J)5OJQJaJ"h{hWL0J)56OJQJaJh{hWLOJPJQJaJh{hWL5OJQJ\aJh{hWLOJQJaJh{h jnOJPJQJaJh{hH%OJQJaJh{h$OJQJaJ\c]ccccd)d*d+d,d7d;dAdHdIdKdbdcdƭٛvcVI:h{hKOJPJQJaJh{hH%OJQJaJh{h$OJQJaJ$h{h^ROJPJQJaJmH sH h{h7OJQJaJmH sH &h{h^R56OJQJaJmH sH #h{h^R5OJQJaJmH sH 0h{h^R0J>*B*OJQJaJmH phsH $h{h^R0J6OJQJaJmH sH h{h^ROJQJaJmH sH )jh{h^ROJQJUaJmH sH cddddee*e+e8ee?e@exe~eeeeeƲsfXfHf5$h{h7OJPJQJaJnHtHh{h756OJQJaJh{h75OJQJaJh{h7OJQJaJh{hY OJPJQJaJ h{hbOJQJaJnHtHh{hbOJQJaJ#h{hPz5OJQJaJnHtH&h{hK56OJQJaJnHtH)h{hKB*OJQJaJnHphtH&h{hK5OJQJ\aJnHtH h{hKOJQJaJnHtHef+f,f9f:fqfwfffffffgggggg ggg(g)g䶤yl_Ph{hxOJPJQJaJh{hxOJQJaJh{h$OJQJaJh{hAOJQJaJh{hRjOJPJQJaJh{hAOJPJQJaJ"h{h`56OJPJQJaJh{hV +OJPJQJaJh{h$OJPJQJaJh{hV +5OJPJQJaJh{hV +OJQJaJh{hV +OJPJQJaJ)gggh$h.h0hBhChchihhiiiiii/iǶ}kk]OB3Bh{h OJPJQJaJh{h}OJQJaJh{h 5OJQJaJh{h`5OJQJaJ"h{h 0J)56OJQJaJh{h 5OJQJ\aJh{h OJQJaJh{h]^FOJPJQJaJh{h]^FOJQJaJ h{h}OJQJaJnHtH&h{hY 56OJQJaJnHtH&h{hY 5OJQJ\aJnHtH h{hY OJQJaJnHtHChiPj4lm nnoqrsrt,uvvxxypzh{9$ & F ^`a$gdDW$ & F -D5$7$8$9DH$M ^`gdDW & F 5$9D^`gdDW/i5iij2jjGjOjPjjk*B*OJPJQJ^Jph2h{h3B*OJQJ^JfHphq "h{h30J)56OJQJ^Jh{h35OJQJ\^Jh{h3OJQJ^Jh{hC5>*OJQJ^J2h{hYkB*OJQJ^JfHphq xxxxxxyy y yyiyjy੒x_N50h{hC5B*OJPJQJaJnHphtH!h{hCB*OJQJaJph0h{hCB*OJPJQJ\aJnHphtH3h{hC5B*OJPJQJ\aJnHphtH-h{hCB*OJPJQJaJnHphtH8h{hU5>*B*OJQJ^JfHphq 2h{hUB*OJQJ^JfHphq h{hUOJPJQJ^Jh{hL5OJPJQJ^J jytyuyvyyyyyyyyyyzUzVz˴r[A[00[!h{h|B*OJQJaJph3h{h|5B*OJPJQJ\aJnHphtH-h{h|B*OJPJQJaJnHphtHh{h|OJPJQJaJh{hCOJPJQJaJh{hCOJQJaJ-h{hLB*OJPJQJaJnHphtH-h{hCB*OJPJQJaJnHphtH3h{hL56B*OJPJQJaJnHphtH3h{hC56B*OJPJQJaJnHphtHVz]zozpzzzz{G{P{Q{V{a{g{h{n{{̽o[F8+h{h8OJQJaJh{h85OJQJaJ)h{h]OJQJaJfHq 'h{h]5OJPJQJaJnHtH*h{h]56OJPJQJaJnHtH!h{h]B*OJQJaJph'h{h]OJPJQJ\aJnHtH$h{h]OJPJQJaJnHtHh{h]OJPJQJaJ-h{h|B*OJPJQJaJnHphtH8h{h56B*OJQJaJfHphq {|D|E|L|N|[|^|_|`|v|||||}}&}'}(}6}ǹueWJh{hOJQJaJh{h`kj5OJQJaJh{h856OJQJaJh{h80JCOJQJaJh{h85OJQJaJh{hiu OJQJaJh{hOOJQJaJh{hFOJQJaJh{hO5OJQJaJ8h{h56B*OJQJaJfHphq h{h8OJQJaJh{h8OJQJ\aJh{v|=}}~|Q>e X0MߋQ%9$ & F ^`a$gdDW & F ^`gdDW6}:}<}=}P}V}X}}}}}}}}}̿}m}`P='=+h{h#q5B*OJPJQJ\^Jph%h{h#qB*OJPJQJ^Jphh{h#q5>*OJQJ^Jh{hBNOJQJ^Jh{hf~?56OJQJ^Jh{hf~?OJQJ^J5h{hf~?5B*OJQJ^JfHphq 2h{hf~?B*OJQJ^JfHphq h{h8OJQJaJ2h{hB*OJQJaJfHphq 2h{h`kjB*OJQJaJfHphq }~~~~~~~~ W_`fhu{ŵ{ePe62h{hT>B*OJQJ^JfHphq (h{hT>6B*OJPJQJ^Jph+h{hT>56B*OJPJQJ^Jph!h{hT>B*OJQJ^Jph+h{hT>5B*OJPJQJ\^Jph%h{hT>B*OJPJQJ^Jphh{h#q5>*OJQJ^J%h{h#qB*OJPJQJ^Jph+h{h#q56B*OJPJQJ^Jph!h{h#qB*OJQJ^Jph{|,:;<JNPQUVX^ݷ{{k]M@2h{hr5OJQJ^Jh{hrOJQJ^Jh{hrH*OJQJ]^Jh{hrOJQJ]^Jh{h5>*OJQJ^J%h{h'B*OJPJQJ^Jph%h{h5B*OJPJQJ^Jph+h{h556B*OJPJQJ^Jph!h{hB*OJQJ^Jph(h{h5B*OJPJQJ^Jph%h{hB*OJPJQJ^Jphh{hT>5>*OJQJ^J^_ijvwĀˀ?T<>^`{aB<h{h0JB5B*OJQJ\^JfHphq 2h{hB*OJQJ^JfHphq h{hr5>*OJQJ^J2h{hrB*OJQJ^JfHphq h{hr56OJQJ^Jh{hrOJQJ]^J h{hr0JHCJOJQJ^Jh{hr0JIOJQJ\^Jh{hrOJQJ^Jh{hrH*OJQJ^J`lJCDPQde ɸəobTbDb7bbh{h.?OJQJ^Jh{hS@56OJQJ^Jh{hS@5OJQJ^Jh{hS@OJQJ^Jh{h5>*OJQJ^J2h{hS@B*OJQJ^JfHphq <h{h0J)56B*OJQJ^JfHphq !h{hB*OJQJ^Jph2h{hB*OJQJ^JfHphq 8h{h5B*OJQJ\^JfHphq   3㽦o_RD22#h{h5OJQJ\^JnHtHh{h55OJQJ^Jh{h5OJQJ^Jh{h35>*OJQJ^J)h{hMaCOJQJ^JfHq h{hMaCOJQJ^J)h{h3OJQJ^JfHq ,h{h35OJQJ^JfHq /h{h356OJQJ^JfHq h{h35OJQJ^Jh{h3OJQJ^Jh{hS@5>*OJQJ^J3FWXagƆ /ȻiN42h{hMaCB*OJQJ^JfHphq 5h{h[HL5B*OJQJ^JfHphq 2h{h[HLB*OJQJ^JfHphq 8h{h[HL56B*OJQJ^JfHphq h{hBlOJQJ^Jh{h[HL5OJQJ^Jh{h[HLOJQJ^Jh{h55>*OJQJ^J#h{h5OJQJ\^JnHtH)h{h556OJQJ\^JnHtH /0345<=?DEFMNOWXYbcejkmuvwyׇϻϻϻϻϻϻϻϻ{a2h{h@B*OJQJ^JfHphq h{h.?OJQJ\^J!h{hpt56OJQJ\^J!h{hpt6OJQJ\]^Jh{hpt5OJQJ\^J'h{hpt0JJ5CJOJQJ^JaJ$h{hpt0JJCJOJQJ^JaJh{hptOJQJ\^Jh{h[HL5>*OJQJ^J%ȈɈ.;<̿rbbREh{h*{OJQJaJh{h*{56OJQJaJh{hdOJQJ\_H aJh{hd5OJQJ_H aJh{hdH*OJQJ_H aJh{hdOJQJ_H aJ h{hcpOJQJ^JmH sH h{h`cOJQJ^Jh{h]OJQJ^J2h{h@B*OJQJ^JfHphq 2h{h.?B*OJQJ^JfHphq <=MZ}Ŋ«‘׃vYF//Fv-h{h2@OJQJaJfHq $h{h2OJPJQJaJnHtH8h{h56B*OJQJaJfHphq h{h2OJQJaJh{h2OJQJ\aJ3h{h5 0J)56OJQJaJfHq ,h{h5 5OJQJaJfHq )h{h5 OJQJaJfHq h{h5 OJQJaJh{h*{OJQJaJh{h*{5OJQJaJ>DENj΋ϋЋҋ֋׋ދߋ гМЇvii[iH$h{h/B*H*OJQJaJphh{h/5OJQJaJh{h/OJQJaJ h{hCVOJQJ^JmH sH )h{ht8OJQJ^JfHq ,h{hCV5OJQJ^JfHq 8h{h56B*OJQJ^JfHphq )h{hCVOJQJ^JfHq h{hCV5OJQJ^Jh{hCVOJQJ^Jpz|Ռی8?PQioz漯nnQC3Ch{h> 5OJQJ\^Jh{h> OJQJ\^J8h{h56B*OJQJaJfHphq !h{hA@B*OJQJaJph0h{hA@5B*OJPJQJaJnHphtH-h{hA@B*OJPJQJaJnHphtHh{hA@OJQJaJh{h/OJQJaJ8h{h9X56B*OJQJaJfHphq 2h{h/B*OJQJaJfHphq zڍz꽣||o\F\55!h{h*AB*OJQJ^Jph+h{h*A5B*OJPJQJ\^Jph%h{h*AB*OJPJQJ^Jphh{h*AOJQJ^Jh{h> OJQJ^J2h{h1?B*OJQJ^JfHphq 2h{h> B*OJQJ^JfHphq )h{h1?OJQJ^JfHq /h{h> 56OJQJ^JfHq )h{h> OJQJ^JfHq $%ޏ$ɲiiR3<h{hc0J)56B*OJQJaJfHphq ,h{hcOJQJ\aJfHq -h{h B*OJPJQJaJnHphtH0h{hc5B*OJPJQJaJnHphtH1h{hc@B*OJPJQJaJnHphtH-h{hcB*OJPJQJaJnHphtHh{h*AOJQJ^J%h{h*AB*OJPJQJ^Jph+h{h*A56B*OJPJQJ^Jph_fghwyq濨vii\OA1AAh{h:.5OJQJ\aJh{h:.OJQJ\aJh{h3OJQJaJh{h8OJQJaJh{hjOJQJaJ8h{h56B*OJQJaJfHphq )h{h8OJQJaJfHq ,h{h85OJQJaJfHq h{hcOJQJaJ2h{hcB*OJQJaJfHphq 2h{hbkB*OJQJaJfHphq q{|}<Bлv`v`MM`v:$h{h25B*OJQJaJph%h{h20JB*OJQJaJph*jh{h2B*OJQJUaJph!h{h2B*OJQJaJphh{hP3lOJQJaJh{h:.OJQJaJ2h{hRlbB*OJQJaJfHphq )h{h:.OJQJaJfHq ,h{hRlb5OJQJaJfHq /h{h:.56OJQJaJfHq BNjړۓܓ4çÇmWB5((h{hEOJQJaJh{h2OJQJaJ(h{h2B*OJPJQJ\aJph"""+h{h25B*OJPJQJ\aJph"""2h{h2B*OJQJaJfHphq ?h{h20J)56B*OJQJ\aJfHphq 6h{h20JVB*OJQJaJfHph"""q 2h{h2B*OJQJaJfHph"""q !h{h2B*OJQJaJph!h{hkB*OJQJaJph B?ݝ & F ^`gd & F ^`gd9 & F ^`gd,6 & F ^`gd|F3 & F ^`gdv(T & F ^`gdDW4:F”ÔŔ̔ԔՔ"-w~ʲ|i[MM@M@M0h{h15OJQJ\aJh{h1OJQJaJh{h1OJQJ\aJh{hEOJQJ\aJ$h{h *B*OJQJ\aJph$h{hEB*OJQJ\aJphh{h2OJQJ\aJ)h{hEOJQJaJfHq /h{hE56OJQJaJfHq 2h{hEB*OJQJaJfHph"""q h{hEOJQJaJh{hE5OJQJaJ &ιΦ^: 2h{h1B*OJQJaJfHphq Gh{h10J\B*OJQJaJeh@fHphq r@Gh{h10J[B*OJQJaJeh@fHphq r@Gh{h10JZB*OJQJaJeh@fHphq r@%h{h1B*OJPJQJaJph(h{h16B*OJPJQJaJph+h{h156B*OJPJQJaJphh{h1OJQJaJh{h1OJQJ\aJ &'ABSYguvі ;qbK4K-h{h7"@OJQJaJfHq -h{h'w@OJQJaJfHq h{h'wOJPJQJaJ"h{hA56OJPJQJaJ h{hAOJPJQJ_H)aJh{hAOJPJQJaJh{hA5OJQJaJh{hAOJQJaJh{h10JXOJQJaJh{h1OJQJaJJh{h10JXB*OJQJ\aJeh@fHphq r@45;ȗ̗ϗїϻzmSS6S8h{hp5B*OJQJ\aJfHphq 2h{hpB*OJQJaJfHphq h{h}x6OJQJaJ2h{h}x6B*OJQJaJfHph333q !h{h]B*OJQJaJph+h{h}x60J)56B*OJQJaJph'h{h}x65B*OJQJ\aJph%h{h}x60JBB*OJQJaJph!h{h}x6B*OJQJaJphh{hAOJQJaJ)+3?#a͚ךϵdS4'h{h UOJQJaJ<h{h U0J)56B*OJQJaJfHphq !h{h UB*OJQJaJph8h{h U5B*OJQJ\aJfHphq 2h{h UB*OJQJaJfHphq h{hpOJQJaJh{h}x6OJQJaJ2h{hpB*OJQJaJfHphq <h{hp0J)56B*OJQJaJfHphq !h{hpB*OJQJaJph9?ƛ͛y\O52hC2h[kB*OJQJaJfHphq hC2h;nIOJQJaJ8hC2h;nI56B*OJQJaJfHph"""q 5hC2h;nI5B*OJQJaJfHph"""q 2hC2h;nIB*OJQJaJfHph"""q 2hC2h9!B*OJQJaJfHphq 8hC2h56B*OJQJaJfHphq hC2h9!5OJQJaJhC2h9!OJQJaJ;Fŝǝܝݝ濲reKe>>0hC2h H*OJQJaJhC2h OJQJaJ2h|F3h|F3B*OJQJaJfHphq h|F3h|F3OJQJaJh|F3h|F356OJQJaJh|F356OJQJaJ)hC2h|F30J]B*OJPJQJaJphhC2h|F35OJQJaJhC2h|F3OJQJaJhC2hkOJQJaJ2hC2h[kB*OJQJaJfHphq 2hC2h;nIB*OJQJaJfHphq #)ipq˾vhXhhGh!h,6h,656OJQJ\aJh,6h,65OJQJ\aJh,6h,6OJQJ\aJ,hbB*OJQJaJfHphq 2hC2h B*OJQJaJfHphq hbOJQJaJhbhbOJQJaJh6hh OJQJaJh6hhbOJQJaJhb56OJQJaJhC2h 5OJQJaJhC2h OJQJaJqzΟ֟؟-3ƬƬƒyƒyk[NAh_Wh_WOJQJaJh_Whv(TOJQJaJh_Wh 56OJQJaJh_Wh 5OJQJaJ0h_Wh 0J6OJQJ\aJfHq 3h_Wh 0J66OJQJ\aJfHq 2h_Wh B*OJQJaJfHph"""q h_Wh OJQJaJh8wOJQJaJh,6h,6OJQJaJ)h,6h,6OJQJaJfHq ʠ̠РҠӠ'9@š̡͡Ρӡԡ̿ffKf0f4h PhB*OJQJ\]fHph"""q 4hwfhB*OJQJ\]fHph"""q 4h$Uh56B*OJQJfHph"""q 1hzh5B*OJQJfHph"""q .hzhB*OJQJfHph"""q h_Wh9OJQJaJh_Wh OJQJaJ2h_Whv(TB*OJQJaJfHphq 2h_Wh_WB*OJQJaJfHphq ԡءڡۡܡ -3Ţ΢ע*0Yӹ~tggRRRR;R,hzh95OJQJaJfHq )hzh9OJQJaJfHq h h OJQJaJh OJQJaJh h 56OJQJaJh h 5OJQJ\aJh h OJQJ\aJhzhOJQJaJ2hAhB*OJQJaJfHphq (hB*OJQJfHph"""q .hAhB*OJQJfHph"""q ΢¤k ;ӧdMө?QV & F v>5$9D^v`>gdE & F v>5$9D^v`>gdE9$a$gdDW ^gdp & F ^`gd Yףۣܣ saaaO@O1Ohx5>*CJOJQJaJhdap5>*CJOJQJaJ"hxh[ 5>*CJOJQJaJ"hxh 5>*CJOJQJaJh~?hpCJOJQJaJh h OJQJaJhzh9@OJQJaJhzh96@OJQJaJ"hzh56@OJQJaJ"hzh956@OJQJaJ,hzh9OJQJ\aJfHq ,hzh#OJQJ\aJfHq  !¤Ф֤פ?MNXk{ץ $*צ &'(;agֹƫ֔{0h{h[ 5B*OJPJQJaJmH phsH -h{h[ B*OJPJQJaJmH phsH h{h[ 6OJQJaJh{h$OJQJaJh{h[ 56OJQJaJh{h[ OJQJaJh{h$5OJQJaJh{h[ 5OJQJaJ-giӧԧק٧ߧ;<OPQcd꬟gP꟟@h{h[ 5OJQJ\aJ,h{h[ 5B*OJQJaJmH phsH 0h{h[ 5B*OJPJQJaJmH phsH h{h[ 5OJPJQJaJh{h[ OJPJQJaJh{h[ OJQJaJh{h[ 0J(OJQJaJ/h{h[ 56B*OJQJaJmH phsH -h{h[ B*OJPJQJaJmH phsH )h{h[ B*OJQJaJmH phsH ר"./0MST©éѩҩөש٩n]L>>h{h"r5OJQJaJ!h{h B*OJQJaJph!h{h[ B*OJQJaJph$h{h[ 5B*OJQJaJph$h{h'5B*OJQJaJph'h{h[ 56B*OJQJaJphh{h"rOJQJaJh{h[ 5OJQJaJh{h[ 56OJQJaJh{h'5OJQJaJ"h{h[ 0J)56OJQJaJh{h[ OJQJaJ*./=?EתTZ\οxxxkV?Vkk,h{hTE5OJQJaJfHq )h{hTEOJQJaJfHq h{hTEOJQJaJh{h x56OJQJaJh{h xOJQJaJh{h x5OJQJaJh{h"rOJQJaJh{ho30J)OJQJaJh{h"r0J)OJQJaJh{ho30J)5OJQJaJ"h{h"r0J)56OJQJaJh{h"r56OJQJaJϫ֫׫7BCPQƬsssbU>>-h{hxB*OJPJQJaJnHphtHh{hxOJQJaJ!h{ht56OJQJ]aJh{htOJQJ\aJh{ht5OJQJ]aJh{htOJQJ]aJh{htOJQJaJ2h{hTEB*OJQJaJfHphq 5h{hTE5B*OJQJaJfHphq <h{hTE0J)56B*OJQJaJfHphq ά׬78<ABLMNRTUV׭п~gMgg@333h{h*TOJQJaJh{hT>OJQJaJ2h{hT>B*OJQJaJfHphq -h{hT>B*OJPJQJaJnHphtH3h{hx56B*OJPJQJaJnHphtH3h{h1Jo56B*OJPJQJaJnHphtHh{hxOJQJaJ!h{hxB*OJQJaJph-h{hxB*OJPJQJaJnHphtH0h{hx5B*OJPJQJaJnHphtH׭ &24گCDJ󸨸wcMChXOJQJaJ+h{h0J)56B*OJQJaJph'h{h5B*OJQJ\aJph%h{h0JBB*OJQJaJph!h{hB*OJQJaJphh{hOJQJaJh{h#56OJQJaJh{h#OJQJaJh{h*T0JKOJQJaJ!jh{h*TOJQJUaJh{h*T5OJQJaJh{h*TOJQJaJEAno}s} & FxgdUl & FgdUl & F ^gdUl & F ^gd0 v5$9D^vgdX & F v>5$9D^v`>gdKF & F v>5$9D^v`>gd- & F v>5$9D^v`>gdX ϰа+-<DE䧔sW>2h-CJOJQJaJ0hXB*CJOJQJaJfHphq 6hXhXB*CJOJQJaJfHphq @hXhfz)0J)56B*CJOJQJaJfHphq %hXhfz)B*CJOJQJaJph:hXhfz)0JB*CJOJQJaJfHphq <hXhfz)5B*CJOJQJ\aJfHphq 6hXhfz)B*CJOJQJaJfHphq EIKMQSUY[]bdfil !$'(-پhKFhKF5OJQJ\aJhKFhKFOJQJaJhKFCJOJQJaJ)hnZ5OJQJ\aJfHq 5hHghnZ56OJQJ\]aJfHq h-OJQJaJh-h-5OJQJ\aJh-h-OJQJaJ2-/0:=>GJKLRWвѲҲٲڲ۲ATZmnoοvkhUl5CJOJQJh{hUl5OJQJaJh{hUlOJQJaJh{h}OJQJaJh{h}5OJQJaJh}hXhXCJ OJQJaJ hKFh-CJOJQJaJhKFOJQJaJ5hKFhKF56OJQJ\]aJfHq hKFhKFOJQJaJ*()*@EGRSTƷը{{kXk$hu4hUlCJOJQJaJnHtHhUlCJOJQJaJnHtHhu4hUlCJOJQJ\aJhUlCJOJQJ\aJhhUlCJOJQJ\aJhhUlCJOJQJaJh:whUlCJOJQJaJh1hUlCJOJQJaJhUlCJOJQJaJh.6hUlCJOJQJaJhUlhUl5>*CJOJQJ*TUj54ݻu gdUl & Fv^vgdUl & FgdUl & F^gdUlgdUl & F ^`gdUl & F 2^2`gdUlTUj ()345IVWĴocJ4cĴ*hUlB*CJOJQJ\aJnHphtH0h9j~hUlB*CJOJQJ\aJnHphtHhUlCJOJQJaJ'hUlB*CJOJQJaJnHph tH3h9j~hUl6B*CJOJQJ]aJnHph tH-h9j~hUlB*CJOJQJaJnHph tHhUlCJOJQJaJnHtH$h9j~hUlCJOJQJaJnHtH3hUlhUl5>*CJOJQJaJfHq hlhUlCJOJQJaJWո߸/Ory!34_ó{{{l{{{{{]{h:5hUlCJOJQJaJhhUlCJOJQJaJhUlCJOJQJ\aJhUlCJOJQJaJh.6hUlCJOJQJaJhUlhUl5>*CJOJQJhlhUl5CJOJQJaJh9j~hUlCJOJQJaJ0h9j~hUlB*CJOJQJ\aJnHphtH'h9j~hUlCJOJQJaJmHnHu"_ɻܻݻYhituǷ֤~nn_PAhQh lOCJOJQJaJhUlhUlCJOJQJaJhZxhUlCJOJQJaJhshUlCJOJQJ\aJhshUlCJOJQJaJ-hshUlB*CJOJQJaJnHphtH$hshUlCJOJQJaJnHtHh:whUlCJOJQJ\aJh:whUlCJOJQJaJhUlCJOJQJaJhUlCJOJQJ\aJh:5hUlCJOJQJ\aJ4vȽ#Mcd%&>?5$9Dgd, $5$9Da$gd, 0*gd,  0*1$gd, D$(1$gd lO h7$8$gd lO ^gd lO4vǽȽ#LMcd}hh}}}})hMh:*|B*OJQJaJnHphtH)hMh,B*OJQJaJnHphtHhMh,6OJQJaJ'hMh,6<B*OJQJaJphhMh,OJQJaJh lOh lOCJOJQJaJhQh lOCJOJQJaJh lO5CJOJQJ\aJ"h lOh lO5CJOJQJ\aJ!$%&>? !$%ckйt hMhDOJQJaJnHtH hMh:*|OJQJaJnHtH#hMh,6OJQJaJnHtH hMh,OJQJaJnHtH,hMh,6B*OJQJaJnHphtHhMh,6OJQJaJhMh,6OJQJ\aJ"hMh,6OJPJ QJ\aJ- !ck7C>itD$ 0*x(1$gd, 0*gdN[ 0*gd,067C>istѽѯѢqqhMh5.OJPJQJaJhMh5.OJQJaJU$hMhN[ <B*OJQJaJphhMhN[ OJQJaJhMh,6OJQJaJ'hMh,6<B*OJQJaJphhMh,OJQJaJ hMh:*|OJQJaJnHtH hMh,OJQJaJnHtH'ty, and that protect against diseases of aging such as diabetes, cardiovascular and Alzheimers diseases. The information will be used to produce diagnostic tests and new therapies and therefore will be of great interest to the public. Role: Co-Investigator IARPA Celniker, Susan (PI) 10/01/17-4/30/2021 Test and evaluation site for FELIX program Role: Co-I Completed Research Support (during the past three years) DE-AC-02-05CH11231 Karpen, Gary H (PI) 10/01/08-09/30/16 Department of Energy Low Dose Scientific Focus Area 102959 A Systems Biology Approach to Assessment of Responses to Low Dose / Low Dose-Rate Ionizing Radiation Four inter-connected SFA research components coordinately investigate low dose responses through complementary studies using both in vivo mouse models of differing radiosensitivity and comparative culture systems for mammary-derived mouse and human cells. Component 1 focuses on non-linear and adaptive response mechanisms in mammary cell culture models. Component 2 uses systems genetics and organotypic culture to understand differences in susceptibility to low-dose radiation-induced mammary tumors. The Integration Hub provides support for advanced technologies and integrative data analysis applied across all components. Role: Component 2 Leader R01 ES021454 Wiese, Claudia (PI) 06/28/12-03/31/17 Colorado State University Subk/Prime: NIH/NIEHS NUCKS, a novel double-strand break repair gene, implicated in cancer biology 102958 Nuclear Ubiquitous Casein and Cyclin-dependent Kinase Substrate (NUCKS) is a 27 kD, DNA-binding and vertebrate-specific protein with previously unknown function. The goal of this project is to further define how NUCKS regulates double-strand break repair (DSBR) capacity using biochemical and cell-based assays, to assess the relevance of its post-translational modifications in response to exogenous DNA damage induction, and to determine the phenotypic consequences of Nucks disruption in mice. Role: Sub-award PI Article miR-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma DE-AC02-05CH11231 Celniker, Susan (PI) 10/01/14-9/30/17 LDRD (Laboratory Directed Research and Development 15-100)/DOE 103083 Microbiome Adaptation in Response to Environmental Challenges The goal of this project is to investigate the impact of pesticides on the gut microbiome and host functions using flies and mice model, which addresses the health component of LBNLs Microbes-to-Biomes Initiative. This information and the approaches developed in this LDRD will serve as a foundation for a large-scale project focused on microbiome-mediated host adaptation to a wider array of environmental challenges. Role: Co-Investigator 24RT-0038 Hang, Bo (PI) 07/01/15-06/30/18 CA/TRDRP Genotoxicity and Novel Biomarkers of Thirdhand Smoke The goal of this study is to further address mutagenic and carcinogenic potential of thirdhand smoke (THS) and to identify potential novel biomarkers for THS. Role: co-PI Accepted Article miR-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma      Jian-Hua Mao, PhD September, 2019 PAGE 9 t"())2ZDZǡf1hMh,@WB*OJPJQJaJnHphtH'hMh,6<B*OJQJaJphhMh,6OJQJaJhMh,6OJQJ\aJ*hMh,6<B*OJQJ]aJphhMh,6OJQJ]aJhMhN[ OJQJaJhMh,OJQJaJh lOh,CJOJQJaJ")Z5ef$-D5$7$8$9DH$M a$gd,$d-D5$7$8$9DH$M a$gd, 0*gd, gd,gd, 0*gd,')5ef&϶϶ϝϐ|nnnaPPPP hMh:*|OJQJaJnHtHhMh:*|OJQJaJhMh,6OJQJaJ'hMh,6<B*OJQJaJphhMh,OJQJaJ1hMh,@B*OJPJQJaJnHphtH1hMh,@B*OJPJQJaJnHphtH-hMh,B*OJPJQJaJnHphtH1hMh,@B*OJPJQJaJnHphtH&RU$d-D5$7$8$9DH$M a$gd{ 0*gd:*|5$9Dgd:*| $5$9Da$gd:*| 0*gd,gd,R !$GIUܿnnSnSn8nn5h{h{@B*CJOJPJQJaJnHphtH5h{h{@B*CJOJPJQJaJnHphtH1h{h{B*CJOJPJQJaJnHphtH9h{h{@WB*CJOJ PJQJ ^JaJnHphtH5h{h{B*CJOJ PJQJ ^JaJnHphtH9h{h{@B*CJOJ PJQJ ^JaJnHphtH hMh:*|OJQJaJnHtH#hMh:*|6OJQJaJnHtHȻsoZIZ hchC\0JCJOJQJaJ)jhchC\0JCJOJQJUaJhC\hchC\CJOJQJhkCJOJQJhchduCJOJQJhchUCJOJQJhch.JCJOJQJhzCJOJQJhchlSCJOJQJhLjhLU1h{h{B*CJOJPJQJaJnHphtH$jh$hL<CJOJQJU$d-D5$7$8$9DH$M a$gd{&`$ ']a$gdzƵ1h{h{B*CJOJPJQJaJnHphtHhLhC\hlShchlSCJOJQJaJ hchC\0JCJOJQJaJ hchlS0JCJOJQJaJ)jhchC\0JCJOJQJUaJ%h 0JCJOJQJaJmHnHu @hxhxxhxhxxhxhxx.........0 P1+8$:p4<0/ =!"#$%z DpDd V  3 $li-arrow"@@^x H02 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@66666PJ _HmH nH sH tH Z`Z Normal$5$7$8$9DH$a$CJOJ QJ _HmH sH tH <<  Heading 1$@&5CJT@T  Heading 2 $|@&]^`|5CJLL  Heading 3$p@&]^p5CJLL H Heading 4$@&^5CJOJQJLL  Heading 5$@&`5CJOJQJF@F  Heading 6$@&5>*CJOJQJF@F  Heading 7$@&5>*CJOJQJ^@^  Heading 8 $0@&]^`05>*CJOJQJD D  Heading 9 $@&5CJOJQJDA`D Default Paragraph FontViV  Table Normal :V 44 la (k (No List BZ@B Plain Text$a$ CJOJ QJ 4 @4 Footer  !4@4 Header  !.)@!. Page NumberP2P NIH biblio. d4d]d^`4ZBZ res exp&$ Hl^`a$ CJOJQJJRJ ref HlH^`H CJOJQJ0>@b0 Title$a$5JPrJ Body Text 2$dh`a$CJTRT Body Text Indent 2 h`h CJOJQJXPX Body Text 2$(^`a$ CJOJQJ\S\ Body Text Indent 3L^`L CJOJQJBBB Body Text ] CJOJQJ0U`0 Hyperlink>*B*JPJ Body Text 20^`0OJQJ@V @ FollowedHyperlink>*B* >Q@> Body Text 3 CJOJQJ(W`( Strong5PP aug!$$d<@& a$5B*OJQJphl^"l Normal (Web)&"$dd5$7$8$9DH$[$\$a$CJOJ PJ QJ aJL/1L author1%7>*CJOJQJS*Y(aJo(ph*A* labellike0Q0 keeptogetherHbH fF Balloon Text&CJOJQJ^JaJb/rb QMDefault '7$8$H$-B*CJOJQJ^J_HaJmH phsH tH *o* +src1 < O +jrnl*O* =2 smalltext\\ rprtbody1 +$""5$7$8$9DH$a$CJOJQJaJPP aux1,$d@5$7$8$9DH$a$CJOJQJaJ`` details1&-$dd5$7$8$9DH$[$\$a$CJOJQJaJ&O& _Ecit-vol(O( _Ecit-sep54O4 _Ecit-first-page4O4 _Ecit-last-page2X"X _desc&2$dd5$7$8$9DH$[$\$a$CJOJQJaJ^2^ _details&3$dd5$7$8$9DH$[$\$a$CJOJQJaJf/Bf HR_FormFillText 4(($OJ PJQJ ^J_HaJmH sH tH ZRZ title&5$dd5$7$8$9DH$[$\$a$CJOJQJaJ.X`a. ":S@Emphasis6]VrV Ktitle17$5$7$8$9DH$a$CJOJQJaJnHtHTT Kdesc28$5$7$8$9DH$a$CJOJQJaJnHtHX`X {qH No Spacing9(CJOJQJ^J_HaJmH nHsH tHe ;{qHHTML PreformattedM:$ 2( Px 4 #\'*.25@95$7$8$9DH$a$$CJOJ PJ QJ aJmHnHsHtH`/` :{qHHTML Preformatted CharCJOJ PJ QJ aJmHsH0a 0 ,0 HTML Cite6]<< ,cit-first-element3** , cit-auth3(( ,cit-sep2,O, `? highlight2:o: &journal-title16]BO!B Capple-converted-space$o1$ !XTitle1nOaBn lO Subtitle 2D$$5$9DH$a$!5>*CJOJPJQJ\^JaJ"/Q" lOl1phRJ@R G lOSubtitleF$<@&a$CJOJPJ QJ^JaJN/qN F lO Subtitle CharCJOJPJ QJ^JaJtH @o@ y:Heading 4 Char 5CJtH 8o8 y:apple-style-span8o8 pt0A55B*CJ \^JaJ ph:o: *Tpublication-title:/: {current-selection/ {_/ {ls2/ {ls3/ {ls46/6 {enhanced-author/! {ls5/1 {ls7/A {ff78/Q8 E0A25B*CJ\^JaJphoa ilN/qN L[highwire-cite-metadata-dateLoL L[highwire-cite-metadata-doi"/" L[labelRoR 1highwire-cite-metadata-volumePoP 1highwire-cite-metadata-issuePoP 1highwire-cite-metadata-pages(o( krcptnamePK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭Vj\{cp/IDg6wZ0s=Dĵw %;r,qlEآyDQ"Q,=c8B,!gxMD&铁M./SAe^QשF½|SˌDإbj|E7C<bʼNpr8fnߧFrI.{1fVԅ$21(t}kJV1/ ÚQL×07#]fVIhcMZ6/Hߏ bW`Gv Ts'BCt!LQ#JxݴyJ] C:= ċ(tRQ;^e1/-/A_Y)^6(p[_&N}njzb\->;nVb*.7p]M|MMM# ud9c47=iV7̪~㦓ødfÕ 5j z'^9J{rJЃ3Ax| FU9…i3Q/B)LʾRPx)04N O'> agYeHj*kblC=hPW!alfpX OAXl:XVZbr Zy4Sw3?WӊhPxzSq]y h 22BBBED Q 0;"%+.062z567I9:;<>T@ACEFCGHLOQcSU&XZN]^}`a\ccde)g/i3lmnAqs+uvxjyVz{6}}{^` 3/<zqB4&qԡYg׭E-TW_teghiklmopqstuvxyz{|}~j }0HChh{fjnrw,@@A[PP(Q;XXY~~ٚhXXXXXX29;E!@ @H 0(  0(  B S  ? OLE_LINK58 OLE_LINK4 _Hlk49964842914dd98e790074c27_fmtSerialNo2 OLE_LINK5 OLE_LINK6_PictureBullets[u2"i_3?33#i ) 6 : *qw <GS\,57@EPJPQY# >D  ryR\rv{~&EM# " # ) t } k!s!!!!!|""""H#R#@$G$$$$$&''' ''B(I((())!)&)+)4)\)d)u)~)))))"*-*:*C***-+7+++++++ , ,+,0,)-0-----~..1/7/K/P/0 00"01060000000112!2M2Q2h2o2y222233j4q4 5 555>5A5555555555566+6467 7%7,797@7J7Q7f7p7778 8;8E89999(:,:i:p:}::::<<======>>>>Y?]???C@G@AAAAnBtBDCHCCCCCfDjDDDDDDDEEFFFFG GyGGiHqH}HHHHHHmIuIyIIIIIICJHJXK`KKKHLOLLLLLvN}N~NNNNOO@PFPQQhRlRRRJSQSiTpTTTTTUUUVCVLVvV|VVV1W;WWWWWZ&ZRZXZhZqZ%[+[/[8[[\\\\\\\] ] ])]7]=]H]Q]U]\]]]]]^^^%^9^?^_"_?_H_``(`/`m`v```aab bbbYb`bbbccccccdd d&d:d?dCdKd~dddd]edeifsfffgghhhhj%jjjkkkkkk`ldlllll~mmmmmmmmmmmmmm?oEo^obovoo0p5pGpOpppqqrrssPsVsZsasnstsss0t8tQtXt{ttttttTv\v`vkvovuvyyzzz'z+z2z6z=zAzKzbzkzozuzzzzz{ {${+{/{8{a{j{{{{{ ||||||||}}p~z~~!'MUYd AGǃ 'IP\bgmy>Bhmw}ŅׅޅDLV\!'!$:Bȋ#*ōˍ ͎Ҏ18<AENU[pvHLĒΒԒhnox;FGNcl#)TYFKʖ).ė֗ٗinz~Øɘ7@ksxƙ!%+#&x>FKQ ),19GJġʡ >AIL38?FmsʳҳagѷкҺW\!"#$&')*,-/0fi)%-%11W2Z2992:5:D DlMqM|rrrr{{8;W]`b3<ciDJܱڳ"#$&')*,-/0EOfi333333333333333333333  ||'' D   4 5 U V i j vvb EY__%))ju{{jjxxQQ\\qqzzG G U U L!L!a!a!`"`"v"v"##$$$$%%%%%%}&}&'''' ( (******++++++}-}-<.<.0043439393446688|9|94:4:;;AANCNCGGNHNH3J3J:Q:QRR2U2UVV?W?W(Y(Y[[\\bbbbcc>m>mqqss{{||}~}~€€,"#$&')*,-/0AACNST`bfi  ||'' D   4 5 U V i j vvb EY__%))ju{{jjxxQQ\\qqzzG G U U L!L!a!a!`"`"v"v"##$$$$%%%%%%}&}&'''' ( (******++++++}-}-<.<.0043439393446688|9|94:4:;;AANCNCGGNHNH3J3J:Q:QRR2U2UVV?W?W(Y(Y[[\\bbbbcc>m>mqqss{{||}~}~€€,"#$$&'')*,-/0AT`abdfi*ZzIB dT=e 7u@S~PXb"5`Jp.|#+x\,0V$?,fjz)<.fjz23XaM%>F5kGG~PXb XtzY;:ZCE^Vtpfjz$>Nsү|n.*^`CJOJQJo(hH^`CJOJ QJ o(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(^`o(. ^`hH. pL^p`LhH. @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PL^P`LhH.@xhh^h`5.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.@xhh^h`5.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.^`o(. ^`hH. pLp^p`LhH. @ @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PLP^P`LhH. ^`56o(.^`.pLp^p`L.@ @ ^@ `.^`.L^`L.^`.^`.PLP^P`L.^`o(.^`.pL^p`L.@ ^@ `.^`.L^`L.^`.^`.PL^P`L.@xhh^h`5.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.^`o(. ^`hH. pL^p`LhH. @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PL^P`LhH.@xhh^h`.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.@xhh^h`.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.^`o(.^`.pLp^p`L.@ @ ^@ `.^`.L^`L.^`.^`.PLP^P`L.@xhh^h`5.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.vv^v`o(. FF^F`hH. L^`LhH.   ^ `hH.   ^ `hH. L^`LhH. VV^V`hH. &&^&`hH. L^`LhH.^`o(. ^`hH. pLp^p`LhH. @ @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PLP^P`LhH.@xhv^v`5.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.@xhh^h`5.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.@xhv^v`5.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.@xhv^v`5.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.@xhh^h`.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.^`CJOJQJo(^`CJOJ QJ o(opp^p`CJOJQJo(@ @ ^@ `CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(^`CJOJQJo(PP^P`CJOJQJo(@xhv^v`5.@xh^`.@xL^`L.@xh^`.@xhT^T`.@xL^`L.@xhp^p`.@xh ^ `.@x L^ `L.)<.CE^?,Vtp23"5CE^ FGGStzYM%>T=e `J#+7u@$>Nsx\,zIn.B;:Z X0 @h h^h`OJQJo(@h h^h`OJQJo(!Tՙ|O0|                  fr*                                                     }'UZ O%*_X ""2EH W?QpAqwDrh l;v~f "'NM@Q>P[%r @Rjr( L.e'8 4j.3C 2YT>;BUXEz xhE_j(~ lM =2ToJO: pUnEfke%?? xh]4R/*o~C6ZfkP}C xh_= L= \c9ewM ds!1 $ hs L/!l N|Ozt- /+~jo  @@& ]w pC~{ d3`wh %@ZE58EuJ6;Vz&&/xf( 6t$; .3(PLO80H0fS5|XI 4f*@sPlH;\O{ %}!N/>[%,4|4Q i4#Pd3(P?BI%PHtj>#{_V;r_nO bEWO{zMS^XmBm"%} Z"LT6_N!VpsD?t0=u<^9NJ|=W4lf}]AqwQs~#$fJ| xh~. 5bi K R>]yds!KlID'=l X8,hF^xY"6Rw<'UB=QZ aU@&/OBfE}IvX ~t0,#UM nU "'"!>L/!$^8C=Z!i>Y}!lMF"^xY"z"`P~ZI/#ps<>##$F"S-$`#%wZGT%{z%p%>/g)%,%SEh h&N1y&R/Vz&l<4/'L./ZhLBv/4%0J1040J1p3Eh1'1NDv xhPY25=2 93=\1P3 d3Y LG3I"4WW8~;4 ,4|4 5s5P`*p%6`#%EuJ6Fyt4O6|P&by7 KG#8u!<$^8880WW8a8R9%`k\V9]\c9LO(VV,9 |95; :1|_F: 4# ; Tc; -;L`Z;[ <"6Eq2I#<(+l<1k`D = UB=*p%6j=_ "" >YVmYT>/$qX@Z>xzD hs\ >-m> >=e?E58e%??I/#D^9N!cg Nn[NR;w_N`wh PNZQ I`RQIe~FSGT% =2T'U"LTUeQ~Td_vUWZ#U)9UI%U_UqnO+UzMS@E&V=e?Vr]p WJcu=WvUNPW6*O|0XOQ 4X~T*_X" y_;Y93i>Y%@ZFlpm\Z 2q`P~Z BZmewZ 4fI- [jlg[OQ/ \=\],kH;\+Ur]Qq^IM 1^}!^] id_D] iPjI"42rj 2{Kj %`kE_j],k*wMk jluG|#l KlC=Z!YVm'P9pn ]ynIFyc8z $#{ewM { h&{ ( ""uG|]1|qDbv} 0}EH-/8}F -B(}UM d(~/+~iQ.3h~;v~@E&V*o~[ <u\~Z ""f(4%0| QZ#UmBm/8}G8r} 3bU''2.qNUVq'x~tKOX=aa,drJQ7b9.?v@[J_`t-z[C -J J [ 8\ / *8 T j   N oO "v ly l > 5 W #~  ( Y N[ ~ r oC4\n*{.9uNk(-1QBF~?<{1=W" ;5DELM0h|b%_ 0&<<hc (:MQ6h<,':_m{7O\q  C5Rlg^%/Odux$_-y|hc&v+1ZyO_ iu y 9{ s!0!u!""7";"KO"S"x"az"|"u#L$R%]#%H%s&S&&%&''n'/(.?(B(K(t()fz)L *@*V +:.+=.+b2+:o+%V,w,x,`&-nQ-u-&w-:.o.}.q/U//004c0141Nj1 22%2C2S2mk2G.3|F3o3u44!4$4a4:5:5~5,6=66oA6[6q6}x66X-7V7I]788E8zH8Q8PY8\8j8t8 99A99e#9a95j9{:M:y:_;)<.<T<~<p.=]=4~=>&>T>GY>1?I?X?`?h?f~?@\@!@O@S@\@*AJ]A*PB CCC(C!YCMaCGeCdD6D;DXD ECETE_EiEF'F6=F@F+WF]^FfF6GHH6HMHsPH`HbH{qH/I?2IEI;nImnIpIA J.J$3JK-K1K\QKcKkK/lK.KhKL&L[HLZkLyM4MQM1NNBN_N/O~HO lOvO.P PPe%PoQ' R"R8R^RdRkRm)S":S(Tv(T)T*T8TDTZT UVVCVluVzV,WP;WDW_WX!XZXY=YLY1Z8Z#;ZPZnZ`wZ)[)[6[D[Q[O\a\ds\] @]C]]w]^^C^ r^_%D_B`[`!a%a-aPaHkab%bE.bSb\bRlbd@7d$cdd*ened!f'f*=fg8gBg_gig((hq"i^,i{j"jRj0kj`kjkk[kbkYukukkllrlP3lBl Vl6hlmvmXnfn jnsno1JoPooop+p]papdapJbpcpupiq rLr r"r3rUr3s8sRdsysptstuwxx xZxbxgx@zxyYyvyz!zEzSz{u%{+Q{:*|L|i|6}<} ~ ~8!~347@ O:Ul 2zp:2C_A@d4y)1WGowwVgS~"T]BCQ\k#4G]: vIa}lt{ 'I]b9MTWe~.FQKx_d0rE .0I<GVTdzC W[ av\0[@i!$(1HD)&/^y=;bKh*Lep34hom 3DlL\Yk'=.M1=KBKNdi@k*0Acf &I]J:=[cK-b0bm14Kl?eU<v}U7Am*.1Ir$ \&=Dmr#J 4bOo f$^( #T,?YA4Xp{/C\9bcfn ALN)W^}D6=^@D#JE7bx !]auQVefss/78 ~>j  6S=k@qE=X\xy$_dnW+Ut3I"M,5.Tm;"A'3;Cp} )dq)!MvuLUs 2<t#.\M #Z+fl0*2b}.690MUb+Mb#J@N@ &>9!=N^f $pnhLGO{GnI ?y;7PReCy1:`cwF^Ra28Pz:UUPQi{(svH5' 4V[#qbC=2IMk<P<F$UL[wf,K'w%)583FI@ Mo"+27jb"dLQ`AQ $^6NFOQi^!r`/4F4ge:PQ`s g>IE( @Ad}59X&''JMj7{:fdknI4,-yKW'N7X u17OPY?z D_j.?"SbpW%AF[9/WLe-#)][kQacd *b=g.is_bc2b5QqRj!3Mg65;ATlSY]|;A3KFR# _p|$&@llll()23:;>?EFGHnoh@@@2h@>@H@N@V@Z@@`@@UnknownG.[x Times New Roman5Symbol3. .[x ArialK (PMingLiUPMingLiU7..{$ CalibriG=  jMS Mincho-3 fgA$BCambria MathI. ??Arial Unicode MSG. P<*Microsoft YaHei7STKaitiOff1Times New Roman;PSimSun[SO; Helvetica?= .Cx Courier New3.[x Times7. [ @Verdana5 *[`)TahomaS  Myriad ProMyriad Pro7$BCambriaC.,.{$ Calibri Light;Wingdings"iK{AG<Q b^Q b^!+nx4 3q+HP ?"2!xxC6 Mostov BIO MASTER 7Department of Anatomy Jian-Hua Maoh                  Oh+'0   @ L X dpxMostov BIO MASTER 7Department of AnatomyNormalJian-Hua Mao391Microsoft Office Word@hh@Μc@F@$P Q ՜.+,D՜.+,H hp   Microsoft^b Mostov BIO MASTER 7 Title 8@ _PID_HLINKSA$,|https://www.researchgate.net/publication/311247774_Thirdhand_Smoke_New_Evidence_Challenges_and_Future_Directions?ev=prf_pub'n 3https://papers.nips.cc/author/alejandro-bujan-9535p @http://www.cell.com/cell-reports/abstract/S2211-1247(14)00829-8}rDhttp://www.landesbioscience.com/journals/epigenetics/article/24626/g=[http://www.omicsonline.org/1948-5956/pdfdownload.php?download=JCST-04-299.pdf%09&&aid=8066 mailto:JHMao@lbl.gov  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWYZ[\]^_abcdefglmpRoot Entry F0z8Po@Data 1TableLWordDocument BSummaryInformation(XDocumentSummaryInformation8`MsoDataStore@06P@06PD01S0D2FQ==2@06P@06PItem  2PropertiesUCompObj r   F Microsoft Word 97-2003 Document MSWordDocWord.Document.89q