ÐÏà¡±á>þÿ %WYþÿÿÿ23456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿì¥Á7 ð¿ËbjbjUU 7|7|ºø ßÿÿÿÿÿÿlhhhô\ $7$7$7,:4`S|*\ Ã7Jè}è}(~~~QñQñQñÊ6Ì6Ì6Ì6Ì6Ì6Ì6 9 -;rÌ6±hQñÓ@QñQñQñÌ6/ø~~U}7/ø/ø/øQñP8~h~Ê6/øQñÊ6/øV/ø…þþÞ¸PhÆ~Ü}`R ~¸À\ È-$7¡óô–Æ4“70Ã7®Ÿ;•ôšŸ;Æ/ø\ \ ÙOPENING SESSION Clyde Auditorium 07:45 - 08:20 Welcome and Medal Presentations Robert R. Edelman, President, ISMRM Carlo Bartolozzi, President, ESMRMB FIFTH ANNUAL LAUTERBUR LECTURE Clyde Auditorium 08:20 - 09:00 From the Genome to Molecular Imaging: Dream or Reality?George K. Radda Medical Research Council London, England, UK PLENARY LECTURESNew Contrast Agents Clyde Auditorium 09:00 - 10:15 Chairs: Jeffrey L. Evelhoch P.V. Prasad Educational Objectives Upon completion of this session, participants should be able to List examples of specific molecular targets which fluorescent probes can be used to identify and/or quantify. Identify approaches that are being used to develop MR contrast agents which can be used to identify and/or quantify specific molecular targets. Explain how a MR contrast agent can be activated by an enzyme. Compare and contrast the advantages and disadvantages of fluorescent probes and MR contrast agents for identifying specific molecular targets. Predict what role targeted MR contrast agents will play in future clinical practice. 9:00 1.Imaging Fluorescent Probes in Living Cells, Tissues and Animals. Stephen R. Adams University of California, San Diego, La Jolla, CA, USA 9:25 2.Affinity-Targeted Contrast Agents Samuel A. Wickline, Gregory M. Lanza Washington University School of Medicine, Saint Louis, MO, USA 9:50 3.Seeing is Believing: Visualizing In Vivo Gene Expression and Secondary Messengers by MRI Thomas J Meade California Institute of Technology, Pasadena, CA, USA Image Reconstruction Methods Clyde Auditorium 11:00 - 13:00Chairs: James G. Pipe E. Mark Haacke 11:00 4.Young Investigator Awards Finalist: Advances in Sensitivity Encoding with Arbitrary k-Space Trajectories Klaas Paul Pruessmann1, Markus Weiger1, Peter Börnert2, Peter Boesiger1 1ETH and University Zurich, Zurich, Switzerland; 2Philips Research, Hamburg, Germany. 11:20 5.Young Investigator Awards Finalist: Unifying Linear Prior-information-driven Methods for Accelerated Image Acquisition — Development of a Broad-use Linear Acquisition Speed-up Technique (BLAST) to Overcome Existing Limitations Jeffrey Tsao1, Babak Behnia1, Andrew Webb1 1University of Illinois at Urbana-Champaign, Urbana, IL USA. 11:40 6.Sum-of-Squares Image Reconstruction with SMASH Michael A. Ohliger1, Charles A. McKenzie1, Ernest N. Yeh1, Mark D. Price1, Daniel K. Sodickson1 1Beth Israel Deaconess Medical Center, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA USA. 11:52 7.New Approaches to Self-Calibrating Parallel Imaging Charles A. McKenzie1, Mark D. Price1, Ernest N. Yeh1, Michael A. Ohliger1, Daniel K. Sodickson1 1Beth Israel Deaconess Medical Center, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA USA. 12:04 8.Push-button PPA Reconstructions: GeneRalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) Mark Griswold1, Peter Jakob1, Robin Heidemann1, Mathias Nittka1, Jianmin Wang2, Berthold Kieffer2 1Universität Würzburg, Würzburg, Germany; 2Siemens Medical Engineering, Erlangen, Germany. 12:16 9.FUSION for Incremental Field-of-View Imaging Yudong Zhu1 1GE Corporate R&D Center, Niskayuna, NY, USA. 12:28 10.Dynamic Imaging by Temporal Modeling with Principal Component Analysis Ananya Sen Gupta1, Zhi-Pei Liang1 1University of Illinois at Urbana-Champaign, Urbana, IL USA. 12:40 11.Establishing T2-Contrast in True FISP Imaging Robin Heidemann1, Mark Griswold1, Claudia Hillenbrand1, Dietbert Hahn2, Axel Haase1, Peter Jakob1 1Universität Würzburg, Würzburg, Germany; 2Institut für Röntgendiagnostik, Würzburg, Germany. RF Coil Design and Applications Lomond 11:00 - 13:00Chairs: Christopher M. Collins Helmut Merkle 11:00 12.A Four Channel Transceive Phased Array Head Coil for 3T Scott B. King1, Randy Duensing2, Stephen Varosi3, David Peterson4, David A. Molyneaux4 1MRI Devices Corporation, Gainesville, FL USA.; 2Applied Resonance Technology, Inc., Gainesville, FL, USA ; 3University of Florida, Applied Resonance Technology, Inc., Gainesville, FL, USA ; 4MRI Devices Corporation, Gainesville, FL, USA. 11:12 13.A Large Volume Four-Ring Birdcage Transmit/Receive Coil for 3.0 T Head Imaging Labros Petropoulos1, Joseph Murphy-Boesch1 1USA Instruments, Aurora, OH, USA. 11:24 14.Open-Face Quadrature "Birdcage" Head Coil Hiroyuki Fujita1, William O. Braum2, Gordon Demeester3 1USA Instruments, Inc., Aurora, OH, USA; 2Marconi Medical Systems, Cleveland, OH, USA; 3Wickliffe, OH, USA. 11:36 15.The Head Cradle: An Open Faced, High Performance TEM Coil J. Thomas Vaughan1, Gregor Adriany1, Michael Garwood1, Peter Andersen1, Kamil Ugurbil1 1The University of Minnesota, Center for Magnetic Resonance Research, Minneapolis, MN, USA; 11:48 16.Design of Planar Strip Array for MRI Ray Lee1 1General Electric Co., Corporate Research & Development Center, Niskayuna, NY, USA. 12:00 17.Ladder Networks for Capacitive Decoupling in Phased-Array Coils * Jovan Jevtic1 1IGC-Medical Advances Inc., Milwaukee, WI, USA. 12:12 18.Arrays of Birdcage Coils for Imaging Multiple Samples Steven M. Wright1, Mary McDougall1, David G. Brown1, John Hazle2 1Texas A&M University, College Station, TX, USA; 2University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. 12:24 19.Two Methods for Multi-Sample Imaging: Applications to Mouse Phenotyping via MRI H. Douglas Morris1, Scott Chesnick1 1National Institutes of Health, Bethesda, MD, USA. 12:36 20.Varactor Tuned Flexible Interventional Receiver Coils Greig Scott1, Garry E. Gold1 1Stanford University, Stanford, CA, USA. 12:48 21.Concentric Coil Arrays for Spatial Encoding in Parallel MRI Michael A. Ohliger1, Robert Greenman1, Charles A. McKenzie1, Daniel K. Sodickson1 1Beth Israel Deaconess Medical Center, Boston, MA, USA. CLINICAL CATEGORICAL COURSECardiac MR Imaging Hall 2 11:00 - 13:00 Chairs: Zahi A. Fayad Christopher M. Kramer Educational Objectives: Upon completion of this course, participants should be able to Describe basic areas of routine and promising use of clinical MR in assessing cardiovascular disease. Describe methodology and interpret results for MR assessment of acquired and congenital heart disease. Apply MR protocols for the evaluation of cardiac morphology, function, viability, and blood flow. Compare approaches for optimal presentation and analysis of cardiac MR results. 11:00 IntroductionDudley J. Pennell 11.25 Congenital Heart Disease Albert de Roos 11:50 MR Coronary Angiography John N. Oshinski 12:15 Atherosclerotic Plaque Characterization Zahi A. Fayad 12:40 Discussion fMRI Data Analysis Hall 5 11:00 - 13:00 Chairs: Mark J. Lowe James J. Pekar 11:00 22.Physiological Noise Reduction in fMRI Using Vessel Time-Series as Covariates in a General Linear Model Torben Lund1, Lars Hanson1 1Hvidovre Hospital, Hvidovre, Denmark. 11:12 23.Detection Of Time Windows Of Brain Responses in fMRI Using Modified Temporal Clustering Analysis Seong-Hwan Yee1, Trevor Andrews1, Jia-Hong Gao1 1University of Texas Health Science Center at San Antonio, San Antonio, TS, USA. 11:24 24.Spatial & Temporal Independent Component Analysis of fMRI Data with Two Task-Related Waveforms James J. Pekar1, Vince Calhoun2, Tulay Adali3, Godfrey D. Pearlson2 1Kennedy Krieger Institute & Johns Hopkins University, Baltimore, MD, USA; 2Johns Hopkins University, Baltimore, MD, USA; 3University of Maryland Baltimore County, Baltimore, MD, USA. 11:36 25.The Use of Spatio-Temporal Properties to Detect Activation in Event-Related fMRI Data Shing-Chung Ngan1, William Auffermann1, Shantanu Sarkar1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 11:48 26.Simulation Studies on the Performance of Independent Component Analysis in Analyzing fMRI Data with Transient, Randomly Occurring Events Hong Gu1, Hanhua Feng1, Wang Zhan2, Su Xu1, David A. Silbersweig1, Emily Stern1, Yihong Yang2 1Weill Medical College of Cornell University, New York, NY, USA; 2Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 12:00 27.Using the Cortical Surface Information for the Detection of fMRI Activation Signal Jean-Baptiste Poline1, Alexandre Andrade1, Ferath Kherif1, Stephane Bahrami1, Isabelle Klein1, Jean-Francois Mangin1, Keith J. Worsley2, Denis Le Bihan1 1SHFJ Commissariat a l'Energie Atomique, Orsay, France; 2McGill University, Montreal, Canada. 12:12 28.Suppresion of Non-Capillary BOLD Signals Through The Use Of Phase Fluctuations Ravi S. Menon1 1The John P. Robarts Research Institute, London, ON, Canada. 12:24 29.Ballistocardiogram Removal and Motion Correction for EEG in the Magnet Patrick L. Purdon1, Iiro P. Jaaskelainen1, Victor Solo2, Emery N. Brown3, John W. Belliveau1, Giorgio Bonmassar1 1Massachusetts General Hospital, NMR Center, Charlestown, MA, USA; 2University of New South Wales, Sydney, NSW, Australia; 3Massachusetts General Hospital, Boston, MA, USA. 12:36 30.Resting State Neurovascular Fluctuation At Different States Of Conciousness. Vesa Johannes Kiviniemi1, Juha-Pekka Kantola1, Bharat Biswal2, Osmo Tervonen1, Jukka Jauhiainen1 1Oulu University Hospital, Oulu, Finland; 2Medical College of Wisconsin, Milwaukee, WI, USA. 12:48 31.Frequencies Contributing to Functional Connectivity in the Cerebral Cortex in "Resting-State" Data Dietmar Cordes1, V.M Haughton1, Konstantinos Arfanakis1, J.D Carew1, P.A Turski1, C.H Moritz1, M.A Quigley1, M.E Meyerand1 1University of Wisconsin-Madison, Madison, WI, USA. MR Imaging of Articular Cartilage Hall 1 11:00 - 13:00 Chairs: Garry E. Gold Douglas W. Goodwin 11:00 32.Comparison of dGEMRIC and T2 Imaging of Articular Cartilage Nina M. Menezes1, Martha L. Gray2, Deborah Burstein3 1Massachusetts Institute of Technology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 2Massachusetts Institute of Technology, Cambridge, MA, USA; 3Beth Israel Deaconess Medical Center, Boston, MA,USA. 11:12 33.GdDTPA2--enhanced T1 Imaging of Proteoglycans Predicts Cartilage Stiffness in Bovine Humeral Head Miika T Nieminen1, Juha Töyräs2, Mikko S Laasanen2, Jarno Rieppo1, Johanna Silvennoinen3, Heikki J Helminen1, Jukka S Jurvelin2 1University of Kuopio, Kuopio, Finland; 2Kuopio University Hospital, Kuopio, Finland; 3A.I.Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland. 11:24 34.Relaxivity of Gadolinium Agents in Cartilage at 2T: Effects on dGEMRIC Imaging Amy M. Gillis1, Martha Gray1, Deborah Burstein1 1Beth Israel Deaconess Medical Center, Boston, MA, USA. 11:36 35.Magnetic Resonance Imaging of Porcine Articular Cartilage before and after Cryopreservation L. Laouar1, K. Fishbein2, N. Jomha1, L. E. McGann1, R.G.S. Spencer2 1University of Alberta, Edmonton, Alberta, Canada; 2National Institutes of Health, Baltimore, MD, USA. 11:48 36.Cartilage Anisotropic Deformation Yields a Dual Role for Proteoglycan Content Jonathan Kaufman1, Umamaheswar Duvvuri1, Ravinder Regatte1, Ravinder Reddy1, John S. Leigh1 1University of Pennsylvania, Philadelphia, PA, USA. 12:00 37.In Vivo Assessment Of Proteoglycan Loss In The Articular Cartilage Of The Goat Knee With Gadolinium-Enhanced MRI After Papain Injection Didier Laurent1, James Wasvary1, Jianyun Yin1, Hem Nalini Singh1, Gary Pastor1, Vincent Blancuzzi1, Elizabeth O'Byrne1, Theodore Pellas1 1Novartis Pharmaceuticals Corporation, Summit, NJ, USA. 12:12 38.Multinuclear MRI Evauation of Cartilage Degeneration Erik M. Shapiro1, Arijitt Borthakur1, Jonathan Kaufman1, John S. Leigh1, Ravinder Reddy1 1University of Pennsylvania, Philadelphia, PA, USA. 12:24 39.Measurement of Cartilage's Internal Elastic Properties Using MR Elastography Anne C. Ridler, Don B. Plewes, and R. Mark Henkelman1 1University of Toronto, Sunnybrook and Women's College Health Sciences Center, Toronto, Ontario, Canada; 12:36 40.Vertical Striations in the Radial Layer of MR Images of Hyaline Cartilage are due to T2 Effects Goodwin D.W.1, Hao Lei1, J. F. Dunn1 1Dartmouth Medical School, Hanover, NH, USA. 12:48 41.Assessment Of Collagen Integrity In Articular Cartilage By Using Magnetization Transfer Imaging: In Vivo Application To The Goat Knee Didier Laurent1, James Wasvary1, Jianyun Yin1, Hem Nalini Singh1, Gary Pastor1, Vincent Blancuzzi1, Theodore Pellas1, Elizabeth O'Byrne1 1Novartis Pharmaceuticals Corporation, Summit, NJ, USA. Peripheral MR Angiography Techniques Forth 11:00 - 13:00Chairs: Stefan G. Ruehm James F.M. Meaney 11:00 42.Multicenter Trial of Steady-State MR Angiography of the Peripheral Arteries with NC100150 (CLARISCAN) for the Evaluation of Peripheral Arterial Disease Tim Leiner1, Kai Yiu J.A.M. Ho1, Vincent B. Ho2, Georg Bongartz3, Willem P. Th. M. Mali4, Jos M.A. van Engelshoven1 1Maastricht University Hospital, Maastricht, The Netherlands; 2Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 3University Hospital Basel, Basel, Switzerland; 4Academic Hospital Utrecht, Utrecht, The Netherlands. 11:12 43.Contrast Enhanced MRA Of The Lower Extremity: Arterial-Venous Transit Of Contrast Bolus And Venous Contamination Yi Wang1, Priscilla A Winchester1, Catherine Zheng Chen1, Richard Watts1, Neil M Khilnani1, Martin R. Prince1 1Cornell University, Weill Medical College, New York, NY, USA. 11:24 44.Contrast-Enhanced, Single-Injection, MRA with Automated Table Movement Compared to Multi-Injection, Time-Resolved CE 3D-MRA of the Run-Off Vessels Thomas Hany1, Timothy Carroll1, Reed Omary1, Emilio Esparza-Coss1, Frank R. Korosec1, Charles A. Mistretta1, Thomas Grist1 1University of Wisconsin-Madison, Madison, WI, USA. 11:36 45.High Resolution Whole Body 3D MR Angiography (AngioSURF): Initial Clinical Experience Mathias Goyen1, Harald H Quick1, Jörg F Debatin1, Mark E Ladd1, Hilmar Kühl1, Silke Bosk1, Jörg Barkhausen1, Stefan G Ruehm1 1University Hospital Essen, Essen, Germany; 11:48 46.Automated Real-time Multi-station Projection MR Angiography (`Bolus Prep´) Hani Marcos1, Peter Choyke1, Vincent B. Ho2, Maureen N. Hood2, Thomas Foo3 1National Institutes of Health, Bethesda, MD, USA; 2Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 3G. E. Medical Systems, Milwaukee, WI, USA. 12:00 47.Contrast Travel Times Measured On 2D Projection MRA In Patients With Peripheral Vascular Disease Martin R. Prince1, Yi Wang1, Richard Watts1, Catherine Chen1, Neil M Khilnani1, David W Trost1, Priscilla A. Winchester1 1Cornell University, Weill Medical College, New York, NY, USA. 12:12 48.3D Gd-Enhanced Moving Table MR Angiography of the Aorta and Outflow Vessels using SENSE to Achieve High Resolution of the Below Knee Vasculature. Jeffrey H Maki1, Gregory J Wilson1, Romhild M Hoogeveen2 1Puget Sound VA HCS, Seattle, WA, USA; 2Philips Medical Systems, Best, The Netherlands. 12:24 49.Improving Spatial Resolution and SNR in Time-Resolved Peripheral MRA Using Extended Dual-Resolution PR Acquisition Jaing Du1, Timothy Carroll1, Karl Vigen1, Yousef Mazaheri2, Charles M. Strother1, B Aargard1, Thomas Hany1, Thomas Grist1, Charles A. Mistretta1 1University of Wisconsin-Madison, Madison, WI, USA; 2Medical College of Wisconsin, Milwaukee, WI, USA. 12:36 50.High Resolution MRA For The Study Of Arteriogenesis In Rodent Models Of Peripheral Artery Disease Simon-Peter Williams1, Joan Greve1, Richard Carano1, Lisa Bernstein1, Adrienne Ross1, Jed Ross1, Nicholas Van Bruggen1 1Genentech, Inc., South San Francisco, CA, USA. 12:48 51.MR Angiography of Hemodialysis Access Grafts and Fistulae using Selective Contrast Injection and Flow Interruption Clemens Bos1, Johannes H.M. Smits2, Jan J. Zijlstra2, Wil A.M.A. Van Der Mark2, Peter J. Blankestijn2, Chris J.G. Bakker2, Max A. Viergever1, Willem P.Th.M. Mali2 1Image Sciences Institute, AZU, Utrecht, The Netherlands; 2University Medical Center Utrecht, Utrecht, The Netherlands. New MR Contrast Agents & Applications Alsh 11:00 - 13:00 Chairs: Jeff W.M. Bulte Gregory M. Lanza 11:00 52.Cellular Imaging using Magnetodendrimers: Application to Human Stem Cells and Neoplastic Cells In Vivo J.W.M Butle1, Trevor Douglas2, P. van Gelderen3, B.K Lewis1, J.A Frank1 1Laboratory of Diagnostic Radiology Research, Bethesda, MD, USA; 2Temple University, Philadelphia, PA, USA; 3National Institutes of Health, Bethesda, MD USA. 11:12 53.MR Molecular Imaging of Her-2/Neu Receptor with Targeted Nanoparticles Dmitri Artemov1, Noriko Mori1, Rajani Ravi1, Zaver Bhujwalla1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA. 11:24 54.Relaxivities of Paramagnetic Nanoparticle Contrast Agents for Targeted Molecular Imaging Patrick Winter1, Junjie Chen1, Sheng-Kwei Song1, Ralph W. Furhop1, Samuel A. Wickline1, Gregory M. Lanza1 1Washington University School of Medicine, St. Louis, MO, USA. 11:36 55.Intracellular Trapping of a Contrast Agent: A Tool for MRI-Based Atraumatic Mapping of Electrotransfer Anne Leroy-Willig1, Elodie Parzy1, G. Vidal2, Pierre Carlier3, C. Wary2, M. Paturneau-Jouas2 1AFM, CEA and INSERM U494, Paris, France; 2Institut de Myologie, France; 3Jemeppe-Sur-Sambre, Belgium. 11:48 56.An MRI Comparative Study on Contrast Enhancement of Necrosis by MP-2269 and Gadophrin-2 in a Rat Model of Liver Infarction Yicheng Ni1, Kofi Adzamli2, Yi Miao1, Erwin Cresens1, Jie Yu2, MP Periasamy2, Max D Adams2, Guy Marchal1 1University Hospitals K.U. Leuven, Leuven, Belgium; 2Mallinckrodt, Inc., St Louis, MO, USA. 12:00 57.Albumin-binding MR Blood Pool Agent Contrast Enhancement in Mouse Glioma Kofi Adzamli1, Dmitriy Yablonskiy2, Michael Chicoine3, Eun Kyung Won3, Karen P. Galen3, Zahner Michael3, Joseph J.H. Ackerman4, Thomas A. Woolsey4 1Mallinckrodt, Inc., St. Louis, MO, USA; 2Olivette, MO, USA ; 3St. Louis, MO, USA; 4Washington University, School of Medicine, St. Louis, MO, USA. 12:12 58.Imaging of Lymphatic Anatomy and Function in Mouse Adults and Pups with GdDTPA-albumin Paul A. Schornack1, Teressa Myloyde1, Zaver Bhujwalla2, Marlys H. Witte1, Robert J. Gillies1 1University of Arizona, Tucson, AZ USA; 2Johns Hopkins University, Baltimore, MD, USA. 12:24 59.Thrombus Detection and Contrast Enhancement Kinetics Using a Novel Fibrin-Targeted MR Nanoparticle Contrast Agent Xin Yu1, Shelton Caruthers2, Scott M. Love1, Michael J. Scott1, Ralph W. Fuhrhop1, Patrick J. Gaffney3, Samuel A. Wickline1, Gregory M. Lanza1 1Washington University, St. Louis, MO USA; 2Rockland, MA, USA; 3St. Thomas's Hospital, London, England, UK. 12:36 60.pH Responsive Gadolinium Chelates as Novel MRI Contrast Agents Yoko Kawata1, Heribert Schmitt-Willich2, Thomas Frenzel2, Hans Bauer2, Hanns-Joachim Weinmann2 1Nihon Schering K.K., Osaka, Japan; 2Schering AG, Berlin, Germany. 12:48 61.A Eu3+-based Magnetization Transfer Contrast Agent Shanrong Zhang1, Patrick Winter2, Kuangcong Wu1, A. Dean Sherry3 1University of Texas at Dallas, Richardson, TX, USA; 2University of Texas Southwestern Medical Center, Dallas, TX, USA; 3University of Texas at Dallas & University of Texas Southwestern Medical Center, Richardson & Dallas, TX, USA. GOLD CORPORATE MEMBER LUNCHTIME SYMPOSIUM Nycomed Amersham Quantitative Perfusion Weighted MRI: Current Clinical Trends and Future Prespectives Argyll (Moat House) 13:00 – 14:00 Chair: Robert R. Edelman Brain – Towards Measuring Metabolism Leif Østergaard Aarhus, Denmark Body – New Perspectives for Kidneys and the Heart Stefan Schoenberg Heidelberg, Germany Panel Discussion Nycomed Amersham ISMRM Fellow’s Presentation: Uterine MRI Suny Abbara University of Hawaii, Honolulu, HI, USA BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Artifact Reduction Lomond Monday: 14:00 - 16:00 Chairs: David Atkinson Charles Mistretta Please see page 137 for details. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) GABA Measurements in Humans & Animals Hall 2 Monday: 14:00 - 16:00 Chairs: Hoby P. Hetherington Ralph E. Hurd Please see page 157 for details. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) RF Coils & Analysis Forth Monday: 14:00 - 16:00 Chairs: Harald H. Quick Peter Styles Please see page 171 for details. CLINICAL SCIENCE FOCUS SESSIONPeripheral MR Angiography Clyde Auditorium 14:00 - 16:00Chairs: Stefan Schoenberg Neil M. Rofsky 14:00 62.Three-dimentional Contrast Enhanced MR Angiography and CT Angiography of Iliac Arteries in Patients with Peripheral Arterial Disease Yoko Saito1, Hiraku Yodono1, Hiroshi Noda1, Hiroyuki Miura1, Keiko Mizuno1, Yoko Itabashi1, Toshiaki Tsuji1, Yoshinao Abe1 1Hirosaki University Hospital, Hirosaki, Aomori, Japan. 14:10 63.MRI versus Multislice Helical CT -Clinical Efficacy in the Assessment of Peripheral Arterial Diseases- Yasuyuki Kobayashi1, Osamu Tanaka1, Katsuhiko Matsuura1, Kenji Hamada1, Naoya Imai1, Tetsuya Yokomizo1, Hiroshi Yamada2, Tomoko Miyata2, Kenji Yodo2 1Omiya Medical Center, Jichi Medical School, Omiya, Japan; 2Toshiba Medical Systems Co., Ltd., Tokyo, Japan. 14:20 64.Aortoiliac And Lower Extremity Arteries MRA: Stepping Table Three-Dimensional Contrast-Enhanced Subtraction MRA Compared To Digital Subtraction Angiography Nicola Montanari1, Paolo Emilio Orlandi, Salvatore Isceri, Imbriani Michele, Sensi Luigi, Angelo Ziosi 1Ospedale Maggiore, Bologna, Italy. 14:30 65.Technical Reliability of Time-Resolved CE MRA for the Assessment of Peripheral Vascular Occlusive Disease. Timothy J Carroll1, J Shannon Swan1, Frank R. Korosec1, Thomas Grist1, Charles A. Mistretta1 1University of Wisconsin-Madison, Madison, WI, USA. 14:40 66.“Shoot and Scoot”: A method For Improving Temporal and Spatial Resolution Of Multistation Peripheral MR Angiography Peter Choyke1, Vincent B. Ho2, Hani Marcos1, Maureen N. Hood2, Wayne Olan3, Bradley Dick4, Sandy Hess1, Thomas Foo5 1National Institutes of Health, Bethesda, MD, USA; 2Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, MD, USA; 3Potomac, MD, USA; 4Suburban Hospital, Bethesda, Bethesda, MD USA; 5G. E. Medical Systems, Milwaukee, WI, USA. 14:50 67.Implementing SENSE in Isotropic Mobitrak CE MRA Roland Bezooijen1, Guillaume Thelissen2, Lucien E.M. Duijm1, Harrie C.M. Vd Bosch1, John Wondergem1, Xander V. Tielbeek1 1Catharina Hospital, Eindhoven, The Netherlands; 2Philips Medical Systems, Best, The Netherlands. 15:00 68.Intraindividual Comparison Of Vascular Enhancement in MRA of Run-Off Vessels Between a Standard and Weak Protein Interaction Gd-chelate Agent (Gd-DTPA vs. Gd-BOPTA) Michael V. Knopp1, Frederik Giesel2, Hendrik von Tengg-Kobligk2, Jannis Radeleff2, Martin Requardt3, Hans Hentrich4 1National Institutes of Health, Bethesda, MD USA; 2German Cancer Research Center, Heidelberg, Germany; 3Siemens AG, Siemens Medical System, Erlangen, Germany; 4Bracco Byk-Gulden, Konstanz, Germany. 15:10 69.Use of a New, Three-Station Phased Array Coil to Optimize Multistation Peripheral MRA Tim Leiner1, Robbert Nijenhuis1, Romhild Hoogeveen2, Bruno Leone2, Jos van Engelshoven1 1Maastricht University Hospital, Maastricht, The Netherlands; 2Philips Medical Systems, Best, The Netherlands. 15:20 70.Improved Multi-Station Peripheral MR Angiography with a Dedicated Vascular Coil Mathias Goyen1, Stefan G Ruehm1, Jörg Barkhausen1, Knut Kröger1, Silke Bosk1, Martin Requardt2, Arne Reykowski2, Jörg F Debatin1 1University Hospital Essen, Essen, Germany; 2Siemens Medical Engineering, Erlangen, Germany. 15:30 71.Improvement Of Visualisation Of The Peripheral Run-Off Vessels With An Additional Sagittal Acquisition Daniel Wilson1, David Kessel1, Susan Downing1, Kathryn Taylor1, Philip Robinson1 1St James's Hospital, Leeds Teaching Hospitals, Leeds, UK. 15:40 72.The Pattern Of Collateral Vessels In The Lower Extremity And Implications For Gene Therapy Delivery Matthew B Wecksell1, Priscilla A Winchester1, Martin R Prince1, Yi Wang1 1Cornell University, Weill Medical College, New York, NY, USA. 15:50 73.Changes in Blood Flow After Sympathetic Nerve Block Measured and Guided by MR Daniel Y. Sze1, Sean Mackey1 1Stanford University, School of Medicine, Stanford, CA, USA. HOT TOPICS FOR CLINICAL PRACTICE Hall 5 14:00 - 16:00 Chairs: William G. Bradley Thomas M. Grist Educational Objectives Upon completion of this course, participants should be able to Describe five points which can be used to improve imaging strategies in important areas of clinical practice. Assess applicability to clinical practice of three newer imaging techniques. The last five minutes of each presentation will be reserved for questions. Fast Protocols 14:00 The 30-Minute Cardiac MR ExamSteven Wolff 14:20 The 30-Minute Abdominal MR ExamDonald G. Mitchell 14:40 To FISP or Not TRUE FISP: When to Use ItJ. Paul Finn Emerging Applications 15:00 MRI of Mad Cow DiseaseDonald Collie 15:20 Diffusion MRIMichael Forsting 15:40 SpectroscopyLawrence Tannenbaum CLINICAL SCIENCE FOCUS SESSIONCartilage and Other Musculoskeletal MR Imaging Hall 1 14:00 - 16:00 Chairs: William B. Morrison Juerg Hodler 14:00 74.Clinical Application of dGEMRIC for Detecting Early Arthritis in the Hip Young-Jo Kim1, Diego Jaramillo2, Martha Gray3, Deborah Burstein3 1Children's Hospital of Boston, Harvard Medical School, Boston, MA, USA; 2Massachusetts General Hospital, Boston, MA, USA; 3Beth Israel Deaconess Medical Center, Boston, MA, USA. 14:10 75.MRI Evaluation of Graft GAG Content: Does Cartilage Transplantation Work? Amy M Gillis1, Adil Bashir1, Brian McKeon2, Arnold Scheller2, Martha Gray1, Deborah Burstein1 1Beth Israel Deaconess Medical Center, Boston, MA USA; 2New England Baptist Hospital, Boston, MA USA. 14:20 76.MRI of Early Cartilage Degeneration following Meniscal Surgery: A Three-Year Longitudinal Study Souhil Zaim1, John A Lynch1, Jing Li1, Harry K Genant1, Charles G Peterfy2 1University of California at San Francisco, San Francisco, CA USA; 2Synarc Inc,, San Francisco, CA USA. 14:30 77.Magnetic Resonance Imaging of Matrix Formation in Cartilage Treated with Ibuprofen and Aspirin S J Ellis1, K Fishbein1, E F Petersen1, L Laouar1, W E Horton2, R GS Spencer1 1National Institutes of Health, Baltimore, MD, U.S.A.; 2Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA. 14:40 78.An International Multicenter Study of the Interreader Agreement in the Assessment of MR Images of Rheumatoid Arthritis Wrist and MCP Joints Mikkel Østergaard1, Mette Karlund1, Marissa Lassere2, Philip Conaghan3, Charles Peterfy4, Fiona Mcqueen5, Phil O'Connor3, Ron Shnier3, Neil Stewart5, Dennis McGonagle3, Paul Emery6, Harry K Genant7, John P. Edmonds8 1University of Copenhagen, Hvidovre Hospital, Hvidovre, Denmark; 2Sydney, Australia; 3Leeds, U.K.; 4Synarc, Inc., San Francisco, CA, USA; 5University of Auckland, Auckland, New Zealand; 6University of Leeds, Leeds, UK; 7University of California, San Francisco, San Francisco, CA, USA; 8University of New South Wales, Sydney, NSW, Australia. 14:50 79.No Change in Cartilage Volume over Three Years in Knee Osteoarthritis Stephen J. Gandy1, Alan D. Brett2, Paul A. Dieppe1, Michael J. Keen3, Rose A. Maciewicz4, Christopher J. Taylor2, John C Waterton4, Iain Watt3 1University of Bristol, Bristol, UK; 2University of Manchester, Manchester, UK; 3United Bristol Healthcare NHS Trust, Bristol, UK; 4AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK. 15:00 80.Knee Osteoarthritis Progression Evaluated by Magnetic Resonance Imaging and a Novel Quantification Software Tool Gilles Beaudoin1, Claude Kauffmann2, Benoit Godbout3, Jean Pierre Raynauld4, Marie-Josée Berthiaume1, Jacques de Guise3, Johanne Martel-Pelletier4, Gary Cline5, Joan Meyer5, Jean-Pierre Pelletier4 1CHUM-Hôpital Notre-Dame, Montréal, QC, Canada; 2Arthrovision, Montréal, QC, Canada; 3École de Technologie Supérieure, Montréal, QC, Canada; 4Osteoarthritis Research Unit, Montréal, QC, Canada; 5Procter & Gamble Pharmaceuticals, Mason, OH, USA. 15:10 81.A Phantom for Quality Control of MRI Knee Cartilage Volume Measurements in Clinical Trials David L. White1, Manish Kothari1, Richard Alan Duray Carano1, Charles G. Peterfy1 1Synarc, Inc., San Francisco, CA, USA. 15:20 82.Rapid High Resolution Cartilage Imaging with FEMR Shreyas S. Vasanawala1, Garry E. Gold1, John M. Pauly1, Dwight G. Nishimura1 1Stanford University, Stanford, CA, USA. 15:30 83.The Precision of Cine-PC and Fast-PC Sequences in Measuring Skeletal Kinematics Andrea J Rebmann1, Tracy Rausch1, Nao Shibanuma2, Frances T Sheehan1 1The National Institutes of Health and, The Catholic University of America, Washington, DC, USA; 2National Institutes of Health, Bethesda, MD, USA. 15:40 84.Interventional MR Imaging of Joints using Intra-Articular Coils Garry E. Gold1, Greig C. Scott2, R. Kim Butts2, John M. Pauly2, Christopher F. Beaulieu2 1Stanford University and the Palo Alto VA, Stanford, CA, USA; 2Stanford University, Stanford, CA USA. 15:50 85.The Influence of Image Plane Selection on Estimates of Patellofemoral Alignment Nao Shibanuma1, Andrea J Rebmann2, Hany Bedair1, Peter E. Lipsky1, Frances T. Sheehan2 1National Institutes of Health, Bethesda, MD, USA; 2The National Institutes of Health and, The Catholic University of America, Mechanical Engineering Department, Washington, DC, USA. CLINICAL SCIENCE FOCUS SESSIONHead and Neck and Brain Imaging Alsh 14:00 - 16:00Chairs: Thomas Schulz Berit Verbist 14:00 86.Measurement of Semicircular Canal Geometry from High-Resolution MRI Petra Schmalbrock1, Robert Holtman1, Antonio Algaze1 1The Ohio State University, Columbus, OH, USA. 14:10 87.High Resolution Imaging of the Internal Auditory Canal Using Fast 3D Steady State Free Precessing (SSFP) Acquisition Yu Liu1, Robert Breger1, Anthony Vu2, Bernice Hoppel2, Tonya Hollrith1, Lynda Yanny1 1St. Luke's Medical Center, Milwaukee, WI, USA; 2GE Medical Systems, Milwaukee, WI, USA. 14:20 88.MRI of Gadolinium (GdDTPA-BMA) Uptake in the Membranous Labyrinth of the Cochlea Börje Bjelke1, Zhengguang Chen1, S. Allen Counter2, Tomas Klason1, Erik Borg1, Maoli Duan3 1Karolinska Institute, Stockholm, Sweden; 2Harvard University, Cambridge, MA, USA; 3ENT Research Laboratory, Stockholm, Sweden; 14:30 89.Functional MRI of the Eustachian Tube in Patients with Clinical Signs of Dysfunction Gabriele Anja Krombach1, Claus C Nolte-Ernsting1, Ercole Di Martino1, A Schuetz1, Andreas Prescher1, Thomas Schmitz-Rode1, Rolf W Guenther1 1University Of Technology, Aachen, Germany. 14:40 90.High Resolution Low Field Imaging with High Temperature Superconducting (HTS) Coils – A New Approach to Susceptibility & Chemical Shift Problems in Head & Neck Imaging Geoffrey Young1, Daniel F. Kacher2, Erzhen Gao3, Kc Chan3, Kelvin Wong3, Simon S.M. Yeung3, Qiyuan Ma3, Ferenc Jolesz2, Edward Yang3 1UCSF Medical Center, San Francisco, CA, USA; 2Harvard University, Brigham & Women's Hospital, Boston, MA, USA; 3Hong Kong University, HK, China; 14:50 91.Cerebellar Morphology in Developmental Dyslexia Caroline Rae1, Jenny A Harasty2, Theresa Dzendrowskyj1, Joel B Talcott3, Judy M. Simpson1, Andrew Blamire3, Ruth Dixon3, Martin A Lee3, Campbell Thompson1, Peter Styles3, Alexandra J Richardson3, John F Stein3 1University of Sydney, Sydney, NSW, Australia; 2Prince of Wales Medical Research Institute, Sydney, NSW Australia; 3The University of Oxford, Oxford, UK. 15:00 92.Brain Structural Abnormalities in Childhood Autism D. W. W. Shaw1, B. Sparks1, S. D. Friedman1, D. Echelard1, E. H. Aylward1, K. Maravilla1, A. A. Artru1, G. Dawson1, S. R. Dager1 1University of Washington, Seattle, WA, USA. 15:10 93.Evidence for Medial Temporal Lobe Pathology in Children with Autism Claire H. Salmond1, John Ashburner1, Karl J. Friston1, Faraneh Vargha-Khadem1, David G. Gadian1 1University College London, London, UK. 15:20 94.Effect of Ionizing Radiation on the Human Brain: White Matter and Gray Matter T1 in Patients Treated with Conformal Radiation R. Grant Steen1, Xioping Xiong, Shengjie Wu, John Glass, Larry Kun, Thomas Merchant 1St Jude Children's Research Hospital, Memphis, TN, USA. 15:30 95.Gray Matter Involvement in Different Multiple Sclerosis Phenotypes: A Diffusion Tensor and Magnetization Transfer Imaging Study Marco Bozzali1, Mara Cercignani1, Giancarlo Comi1, Massimo Filippi1 1Scientific Institute HSR, Milan, Italy. 15:40 96.Total Cerebral Blood Flow Studies in CADASIL Rivka Van Den Boom1, Saskia A.S. Lesnik Oberstein1, Aart Spilt1, Joost Haan1, Mark Van Buchem1 1Leiden University Medical Center, Leiden, The Netherlands. 15:50 97.Neuroimaging Markers of HIV Disease in the Central Nervous System: A Role For Diffusion Tensor Imaging and Diffusion Distribution Maps Christopher G. Filippi1, Elizabeth Ryan1, Steven J. Ferrando1, Wilfred G. van Gorp1, Aziz M. Ulug1 1Weill Medical College of Cornell University, New York, NY, USA. Perfusion Methodology Clyde Auditorium 16:30 - 18:30 Chairs: Alfonso C. Silva Fernando Calamante 16:30 98.Quantitative Measurement of Cerebral Venous Blood Volume and Cerebral Blood Oxygen Saturation: Effect of Static Magnetic Field Inhomogeneity Hongyu An1, Weili Lin2 1Washington University, St. Louis, MO, USA; 2University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 16:40 99.Comparison of Dynamic Susceptibility Contrast and Continuous Arterial Spin Labeled Perfusion MR Techniques in Patients with Cerebrovascular Disease Ronald Wolf1, David Alsop1, Joseph Maldjian1, John Detre1 1University of Pennsylvania, Philadelphia, PA, USA. 16:50 100.Modelling of Arterial Spin Labelled Perfusion Data with Varying Delay Time, Including Permeability Effects Laura Parkes1, Paul Stephen Tofts1 1University College London, Institute of Neurology, London, UK. 17:00 101.Arterial Transit/Trailing Time Changes During Brain Activation: Their Effects on CBF Quantification in Multislice ASL Perfusion Imaging Yihong Yang1, Engelien Wolfgang1, Su Xu2, Hong Gu1, Wang Zhan1, Hanhua Feng1, David A. Silbersweig1, Emily Stern1 1Weill Medical College of Cornell University, New York, NY, USA; 2Memorial Sloan-Kettering Cancer Center, Department of Medical Physics, New York, NY, USA. 17:10 102.Perfusion Imaging at 3.0T using Arterial Spin Labeling with a Three-Coil System Emmanuel L. Barbier1, Scott Chesnick1, Garry Shen1, Afonso Silva1, Alan Koretsky1, S. Lalith Talagala1 1National Institutes of Health, Bethesda, MD, USA. 17:20 103.Imaging Arterial Blood Volume Using Dynamic Arterial Spin Labeling (DASL) Emmanuel Barbier1, Afonso Silva1, Alan Koretsky1 1National Institutes of Health, Bethesda, MD, USA. 17:30 104.Arterial Input Function Measurements with Gradient Echo Sequences Matthias J.P. Van Osch1, Chris J.G. Bakker2, Max A. Viergever1 1Image Sciences Institute, AZU, Utrecht, Netherlands; 2University Medical Center Utrecht, Utrecht, The Netherlands. 17:40 105.The Influence Of Vessel Misregistration Induced By Paramagnetic Contrast Agents On The Arterial Input Function Measured With EPI Martin Rausch1 1University Hospital/Kantonsspital Basel, Basel, Switzerland. 17:50 106.Minimizing Inaccuracy and Variability for Quantitative Estimates of CBF in Unilateral Carotid Artery Occlusion Patients: a PET and MR Study Weili Lin1, Azim Celik2, Colin P Derdeyn3, Hongyu An3, Yueh Z. Lee1, Tom Videen3, Leif Østergaard4, William J. Powers3 1UNC-Chapel Hill, Chapel Hill, NC, USA; 2GE Medical Systems, Millwaukee, WI, USA; 3Washington University, St. Louis, MO, USA; 4Aarhus University Hospital, Aarhus, Denmark. 18:00 107.On the Theoretical Basis of Perfusion Measurements by Dynamic Susceptibility Contrast MRI Valerij G. Kiselev1 1Freiburg University Hospital, Freiburg, Germany. Fast Cardiac Imaging Lomond 16:30 - 18:30Chairs: Dwight G. Nishimura Peter Boesiger 16:30 108.Real Time And Segmented True FISP Cardiac Cine Using Radial Sampling Ajit Shankaranarayanan1, Orlando Simonetti2, Gerhard Laub2, Oliver Heid3, Jonathan S Lewin4, Jeffrey L Duerk5 1Case Western Reserve University, Cleveland, OH, USA; 2Siemens Medical Systems, Chicago, IL USA; 3Siemens Medical Systems, Erlangen, Germany; 4University Hospitals of Cleveland, Cleveland, OH USA; 5Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA. 16:42 109.Dual RF Flip Angle TrueFISP Cardiovascular MRI R. D. Merrifield1, J. Keegan2, D. N. Firmin3, G. Z. Yang1 1Imperial College of Science, Technology and Medicine, London, UK; 2Royal Brompton Hospital, London, UK; 3National Lung and Heart Institute, London, UK. 16:54 110.Multi-Echo TrueFISP in the Heart Daniel A. Herzka1, Michael A. Guttman2, Anthony H. Aletras2, Elliot R. McVeigh2 1Johns Hopkins University, Baltimore, MD, USA; 2National Institutes of Health, Bethesda, MD, USA. 17:06 111.Real-Time Imaging of Cardiac Strain using Ultra-Fast HARP Sequence Smita Sampath1, J. Andrew Derbyshire2, Nael F. Osman1, Ergin Atalar1, Jerry L. Prince1 1Johns Hopkins University, Baltimore, MD, USA; 2GE Medical Systems, Waukesha, WI, USA. 17:18 112.Single Breath-hold Single-Phase and CINE 3D Acquisition using Variable Temporal k-space Sampling Thomas K.F. Foo1, Vincent B. Ho2, Dara Kraitchman3 1GE Medical Systems, Johns Hopkins University, Baltimore, MD, USA; 2Uniformed Services University of the Health Sciences, Bethesda, MD USA; 3Johns Hopkins University, Baltimore, MD, USA. 17:30 113.3D Cardiac Cine Imaging in a Single Breathhold using Elliptically Reordered 3D TrueFISP Klaus Scheffler1 1Universität Freiburg, Freiburg, Germany. 17:42 114.Real-Time Quantitative Flow Using EPI and SENSE Romhild Hoogeveen1, B. Leone1, J. v.d. Brink1 1Philips Medical Systems, Best, The Netherlands. 17:54 115.Real-Time MRI Assessment of the Relation Between Breathing Pattern and Cardiac Hemodynamics R.J. van den Hout1, H.J. Lamb1, J.G. van den Aardweg1, P. Steendijk1, A. de Roos1 1Leiden University Medical Center, Leiden, The Netherlands. 18:06 116.Real-Time Interleaved Multiple Cardiac View SSFP-EPI Using SENSE Johan Van Den Brink1, Gert Van Yperen1, Tom Rozijn1, Stefan Fischer2, Rudolf Springorum1, Jouke Smink1, Marc Kouwenhoven1 1Philips Medical Systems, Best, Netherlands; 2St. Louis, MO, USA. 18:18 117.Detecting the Onset of Ischemia Using Real-time HARP Dara Kraitchman1, Smita Sampath1, John Derbyshire1, Alan W. Heldman1, Elias Zerhouni1, David A. Bluemke1, Jerry Ladd Prince1, Nael F. Osman1 1Johns Hopkins University, Baltimore, Md, USA. MR PHYSICS AND TECHNIQUES FOR CLINICIANS Hall 2 16:30 - 18:30Chairs: Frank R. Korosec Joseph C. McGowan Educational ObjectivesAt the conclusion of this course, participants should be able to Define and describe the fundamental principles of MR imaging, including spin magnetization, the Larmor relationship, relaxation phenomena, and the process of using the spin magnetization to produce an image. Explain imaging pulse sequences based upon spin and gradient echoes, including fast spin echo and echo planar techniques. Design MR imaging protocols for diagnostic applications considering image contrast, spatial resolution, acquisition time, signal-to-noise ratio, and artifacts. Describe the principles and capabilities of various advanced MR techniques including perfusion and diffusion, functional, interventional, and cardiac MR imaging. 16:30 Spin Gynmastics I Donald B. Plewes 17:10 Spin Gymnastics IIDonald B. Plewes 17:50 Hardware Richard G.S. Spencer Image Processing: Brain Hall 5 16:30 - 18:30Chairs: Hamid Soltanien-Zadeh Michael W. Weiner 16:30 118.Young Investigator Awards Finalist: 4D Deformation Modeling of Cortical Disease Progression in Alzheimers Dementia Andrew Janke1, Greig De Zubicaray1, Stephen E. Rose1, Mark Griffin1, Johnathan B Chalk Jr1, Graham J. Galloway1 1University of Queensland, Brisbane, Queensland, Australia. 16:50 119.Structure-Driven Image-Warping for Anatomical Labeling of Human Brain MRI Dominik S Meier1, Elizabeth Fisher1 1Cleveland Clinic Foundation, Cleveland, OH, USA. 17:02 120.Fast Distortion Registration of 2D MR Images Peter Zhilkin1, Murray Alexander1, Lawrence Ryner1 1National Research Council, Winnipeg, MB, Canada. 17:14 121.Study of Cortical Folding Process with Prenatal MR Imaging A. Cachia1, J.-F. Mangin1, N. Boddaert2, J. Régis3, F. Kherif1, P. Sonigo2, M. Zilbovicius1, I. Bloch4, F. Brunelle2 1SHFJ, CEA, Orsay, France; 2Hopital Necker, Paris, France; 3CHU La Timone, Marseille, France; 4ENST, Paris, France. 17:26 122.A Virtual Expert Of Cortical Folding Patterns Jean-Francois Mangin1, Denis Rivière1, Dimitri Papadopoulos-Orfanos1, Jean Régis2 1SHFJ, CEA, Orsay, France; 2CHU La Timone, Marseille, France. 17:38 123.Quantitative Analysis Of Multiple Scelerosis By Segmentation Of Multi-Spectral Volumetric MR Images Dongqing Chen1, Wei Huang1, Chris Christodoulou1, Lihong Li1, Dykei Yoon1, Alina Tudorica1, Patricia Roche1, W Scherl1, Robert Peyster1, Clemente Roque1, Pat Melville1, V Geronimo1, Lauren Krupp1, Zhengrong Liang1 1State University of New York at Stony Brook, Stony Brook, NY, USA. 17:50 124.Automatic, Accurate Segmentation of the Brain and CSF in T1-weighted Volume Scans and its Application to Serial Volumetry Louis Lemieux1 1University College London, Institute of Neurology, Chalfont St. Peter, UK. 18:02 125.Principal Diffusion Direction Field Regularisation for Diffusion tensor Magnetic Resonance Images Olivier Coulon1, Daniel Alexander1, Simon R. Arridge1 1University College London, London, UK. 18:14 126.Noise Removal with Tissue Boundary Preservation Using Fourth-Order Partial Differential Equations Marius Lysaker1, Arvid Lundervold1, Xue-Cheng Tai1, Michael Bock2, Lothar Schad2 1University of Bergen, Bergen, Norway; 2German Cancer Research Center (DKFZ, Heidelberg, Germany. Functional MR Imaging of Spine & Muscle Hall 1 16:30 - 18:30Chairs: John A. Carrino Adam Flanders 16:30 127.MRI of Neuronal Recovery in Spinal Cord Injury Ponnada Aswadha Narayana1, Russell Abbe1, Ray Grill1, Mehmet Bilgen1 1University of Texas - Houston Health Science Center, Houston, TX, USA. 16:42 128.Displacement Imaging Of Hemi-Crush In Rat Spinal Cord Using Heavily Diffusion-Weighted MRI Revital Nossin Manor1, Revital Duvdevani2, Rinat Oz3, Yoram Cohen1 1Tel-Aviv University, Tel-Aviv, Israel; 2Kiryat Weizmann, Rehovot, Israel; 3IIBR, Ness Zionna, Israel. 16:54 129.A Pharmacokinetic Model For Quantitative Evaluation Of Spinal Cord Injury With Dynamic Contrast-Enhanced MRI Mehmet Bilgen1, Ponnada Aswadha Narayana1 1University of Texas - Houston Health Science Center, Houston, TX, USA. 17:06 130.3D MR Tracking of Magnetically Labeled Embryonic Stem Cells Transplanted in the Contusion Injured Rat Spinal Cord J.W.M Bulte1, J. Lu2, H. Zywicke1, P. van Gelderen3, Trevor Douglas4, J.W. McDonald2, J.A. Frank1 1Laboratory of Diagnostic Radiology Research(CC), Bethesda, MD, USA; 2Washington University, St. Louis, MO, USA; 3National Institutes of Health, Bethesda, MD USA; 4Temple University, Philadelphia, PA, USA. 17:18 131.Spinal fMRI of the Rat Cervical Spinal Cord Krisztina Malisza1, Patrick Stroman1 1National Research Council Canada, Winnipeg, MB, Canada. 17:30 132.Signal Enhancement by Extravascular Protons (SEEP) in Spinal fMRI Patrick Stroman1, Vicky Krause1, Krisztina Malisza1, Uta Frankenstein1, Boguslaw Tomanek1 1National Research Council-Canada, Winnipeg, MB, Canada. 17:42 133.Measurement of Skeletal Muscle Velocities Using Real-Time MR Imaging Deanna Schmidt Asakawa1, Garry E. Gold1, S. Blemker1, Krishna Nayak1, John M. Pauly1, Dwight G. Nishimura1, Scott L. Delp1 1Stanford University, Stanford, CA, USA. 17:54 134.Age and Atherosclerosis Adversely Affect Skeletal Muscle Functional Recovery Following Femoral Artery Ligation in the Mouse: MRI Assessment of Functional Hyperemia Joan Greve1, Lisa Bernstein1, Simon-Peter Williams1, Lyn Powell-Braxton1, Frank Peale1, Stuart Bunting1, Nicholas Van Bruggen1 1Genentech, Inc., South San Francisco, CA, USA. 18:06 135.BOLD MRI and NIRS Detection of Transient Hyperemia After Single Skeletal Muscle Contractions. Ronald Meyer1, Kevin McCully2, Robert W Reid1, Barry Prior1 1Michigan State University, East Lansing, MI, USA; 2University of Georgia, Athens, GA, USA. 18:18 136.The New Approach of Skeletal Muscle Contraction Imaging Yasuharu Watanabe1, Chuzo Tanaka1, Toshihiko Ebisu1, Masahiro Umeda1, Yoshiaki Someya1, Yuuki Mori1, Masaki Fukunaga1, Ichio Aoki1, Shoji Naruse2 1Meiji University of Oriental Medicine, Kyoto, Japan; 2Kyoto Prefectural University of Medicine, Kyoto, Japan. Tumor Response Assessment Forth 16:30 - 18:30 Chairs: Jason A. Koutcher Arend Heerschap 16:30 137.Effects of Motexafin Gadolinium on Tumor Metabolism and Radiation Sensitivity S. Xu1, K. Zakian1, H. Thaler1, C. Matei1, A. Alfieri2, Y. Chen1, J. Koutcher1 1Memorial Sloan-Kettering Cancer Center, New York, NY, USA; 2Albert Einstein College of Medicine, Bronx, NY, USA. 16:42 138.Prostate Cancer: Effect of Extensive Post-biopsy Hemorrhage on Interpretation of 1H MRSI Data Saying Li1, Daniel B. Vigneron1, Penelope J Wood1, Mark G. Swanson1, John Kurhanewicz1 1University of California, San Francisco, San Francisco, CA, USA. 16:54 139.Serial MRSI Studies Monitoring Brachytherapy of Prostate Cancer Penelope Jayne Wood1, Daniel B. Vigneron1, Saying Li1, Kristin Lee Wright1, Mark Swanson1, Joycelyn Speight1, John Kurhanewicz1 1University of California, San Francisco, San Francisco, CA, USA. 17:06 140.Radiation-Therapy-Induced Brain Injury As Quantified By Whole-Brain 1H MRS Belinda S.Y. Li1, Benjamin Movsas1, James S. Babb1, Oded Gonen1 1Fox Chase Cancer Center, Philadelphia, PA, USA. 17:18 141.Prediction of Clinical Outcome for Cancer of the Cervix using Dynamic Contrast Enhanced MR Imaging Andrew P Jones1, Johnathan R Sykes1, Bernadette M Carrington1, Julie A Loncaster2, Susan M Todd1, David L Buckley3, Catherine M L West2 1Christie Hospital, Manchester, UK; 2Paterson Institute for Cancer Research, Manchester, UK; 3University of Manchester, Manchester, UK. 17:30 142.Gd-DTPA Parametric Imaging of Tumor Necrosis After Neoadjuvant Chemotherapy J P Dyke1, D P Panicek1, P A Meyers1, J H Healey1, A G Huvos1, L H Schwartz1, J A Koutcher1, D Ballon1 1Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 17:42 143.Early Response of Prostate Carcinoma Xenograft to Taxotere Chemotherapy Monitored with Diffusion MRI. Dominique Jennings1, B. Nicholas Hatton1, Jean-Philippe Galons1, Theodore Trouard1, Natarajan Raghunand1, Robert Gillies1 1University of Arizona, Tucson, AZ, USA. 17:54 144.Tumour ADC as a Predictor of Response to Combined Radiation and Chemotherapy in Locally Advanced Human Rectal Cancers. ASK Dzik-Jurasz1, C Domenig2, M George3, J Wolber1, G Brown4, AR Padhani1, I Swift3, JE Husband4, MO Leach1, S Doran2 1Institute of Cancer Research, Sutton, UK; 2University of Surrey, Guildford, UK; 3Mayday University Hospital, Croydon, UK; 4Royal Marsden NHS Trust, Sutton, UK. 18:06 145.Monitoring Response to Convection Enhanced Taxol Delivery in Brain Tumor Patients Using Diffusion Weighted MRI Yael Mardor1, Yiftach Roth1, Zvi Lidar1, Tali Jonas1, Ami Glicksman1, Raphael Pfeffer1, Stephan E Maier2, Meir Faibel1, David Tanne1, Dvora Nass1, Moshe Hadani1, Arie Orenstein1, Jack S Cohen1, Zvi Ram1 1Sheba Medical Center, Tel-Hashomer, Israel; 2Harvard University, Brigham and Women's Hospital, Boston, MA, USA. 18:18 146.Pelvic MR Scans for Radiotherapy Planning: Correction of System and Patient-Induced Distortions Simon J Doran1, Liz Moore2, Martin O Leach2 1University of Surrey, Surrey, England, UK; 2Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, UK. MR Imaging of Multiple Sclerosis Alsh 16:30 - 18:30Chairs: Vincent Dousset Michael Forsting 16:30 147.Occult Disease in Gray and White Matter Differ between Subtypes of MS by Diffusion MR Histograms Archana B. Rao1, Maj Hedehus1, Bradley Betts1, Annette Langer-Gould1, Michael E. Moseley1, Scott W. Atlas1 1Stanford University, Stanford, CA, USA. 16:42 148.Diffusion Tensor Imaging of Basal Ganglia in Multiple Sclerosis Olga Ciccarelli1, David Werring1, Claudia Wheeler-Kingshott1, Gareth Barker1, Geoffrey Parker1, D. H. Miller1, A. J. Thompson1 1University College London, London, UK. 16:54 149.Intra-Voxel and Inter-Voxel Coherence in Patients with Multiple Sclerosis Assessed by Diffusion Tensor MRI Mara Cercignani1, Marco Bozzali1, Giancarlo Comi1, Massimo Filippi1 1Scientific Institute HSR, Milan, Italy. 17:06 150.Evaluation of the Physiological State of White Matter by High b Value q-Space Analyzed Diffusion Weighted Imaging: Applications to Multiple Sclerosis Yaniv Assaf1, Dafna Ben-Bashat2, Sharon Peled2, Joab Chapman1, Yoram Segev2, Talma Hendler2, Amos D Korczyn1, Moshe Graif2, Yoram Cohen1 1Tel Aviv University, Tel Aviv, Israel; 2Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 17:18 151.Brain Adaptive Changes Following Tissue Damage in PPMS: A Multiparametric Study using fMRI, MTI and DTI Maria A Rocca1, Andrea Falini1, Elisabetta Pagani1, Giancarlo Comi1, Giuseppe Scotti1, Massimo Filippi1 1Scientific Institute HSR, Milan, Italy. 17:30 152.Diffusion, Magnetization Transfer and Spectroscopic Imaging of Corpus Callosum in Clinically Isolated Syndromes suggestive of Multiple Sclerosis Jean-Philippe Ranjeva1, Sylviane Confort-Gouny1, Yann Le Fur1, Patrick Viout1, Sandrine Guis1, Virginie Laguitton2, Jean Pelletier2, Patrick J Cozzone1 1Faculte de Medecine, Marseille, France; 2CHU Timone, Marseille, France. 17:42 153.Co-localization of Changes in ADC, T1-relaxation Time and 1H-Metabolite Concentrations in MS-lesions Gisela E Hagberg1, Johnson J Valancherry1, Fabrizio Fasano1, Ugo Nocentini2, Umberto Sabatini1, Jerome N Sanes1, Alessandro Castriota-Scanderbeg1 1Fondazione Santa Lucia, Rome, Italy; 2Tor Vergata University, Rome, Italy. 17:54 154.Dynamic Changes of Acute Hypointense MS Lesions ("Black-Holes") on Unenhanced T1 Weighted MR1 Guo-Jun Zhao1, David KB Li1, Donald W Paty1, UBC MS/MRI Research Group1 1University of British Columbia, BC. Canada. 18:06 155.Whole Brain T1 Relaxometry in Multiple Sclerosis Stuart Clare1, Allyson Parry1, Peter Jezzard1 1University of Oxford, John Radcliffe Hospital, Oxford, UK. 18:18 156.White and Grey Matter Atrophy in Clinically Early Relapsing Remitting Multiple Sclerosis D.T. Chard1, Colette Maria Griffin2, Geoffrey Parker2, A. J. Thompson1, D. H. Miller1 1University College London, London, England, UK; 2Institute of Neurology, London, UK. BRONZE CORPORATE MEMBER SYMPOSIABracco Hall 5 18:30 – 20:00 Toward Improved Contrast Enhancement MR Imaging of the CNS Mark A. van Buchem Leiden, The Netherlands MR Imaging of the Breast Michael W. Bourne Cardiff, UK MR Imaging of the Liver Günther Schneider Homburg, Germany MR Angiography Michael V. Knopp Bethesda, USA BRONZE CORPORATE MEMBER SYMPOSIABruker Medical, Inc.High Field MRI Studies of Brain Injury Lomond 18:30 – 20:00 High Field MRI Studies of Brain Injury T. A. Carpenter Wolfson Brain Imaging Centre, Cambridge, UK BRONZE CORPORATE MEMBER SYMPOSIASchering AGChallenges in MRI Hall 2 18:30 – 20:00 Challenges in MRI Hans Schild Germany STUDY GROUPDynamic NMR Spectroscopy Alsh 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 STUDY GROUPMR Engineering Forth 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 STUDY GROUPMR of Cancer Hall 1 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 STUDY GROUPMR Imaging Efficacy and Effectiveness Boisdale 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 MORNING CATEGORICAL COURSEEmerging Body MRI Applications Hall 1 07:00 -08:00Chairs: Neil M. Rofsky David J. Lomas Educational ObjectivesUpon completion of this course, participants should be able to Recognize the relevance of recent MRI technology developments to diagnostic imaging of the chest, abdomen, and pelvis. Identify the role of fast imaging sequences in body MRI techniques. Describe new imaging applications for evaluating abnormalities of the abdominal and pelvic organs. Implement new protocols for functional imaging of the lung, pancreas, kidney, prostate, and pelvic floor. Recognize the potential value of new methods for interpreting body MRI data. The final five minutes of each talk will be reserved for questions. 07:00 Pulmonary MRIQun Chen 07:30 Imaging the GI TractDavid J. Lomas MORNING CATEGORICAL COURSEHigh Field Imaging, Spectroscopy, and fMRI Hall 2 07:00 - 08:00Chairs: Arend Heerschap J. Thomas Vaughan Kamil Ugurbil Educational ObjectivesUpon completion of this course, participants should be able to List and explain the advantages of imaging, spectroscopy and fMRI at field strengths of 3T and higher compared to 1.5T and lower. Describe the basic components of a high-field system for clinical imaging and research. Imaging: List clinical imaging methods, applications and research directions enhanced by high-field MRI. Spectroscopy: Appraise spectroscopy as a diagnostic tool at 3T; review research progress at fields to 7T. fMRI: Evaluate the clinical potential of fMRI at 3T and research applications to 7T; explain fMRI contrast mechanisms and their dependency on field strength. Recognize the role(s) of high-field fMRI in the clinic or laboratory. The final 7 minutes of each talk will be reserved for questions. Instruments 07:00 High Field B0Rory Warner 07:30 High Field B1J. Thomas Vaughan MORNING CATEGORICAL COURSEfMRI: What Can We Measure? Hall 5 07:00 - 08:00 Chairs: Linda Chang Peter Jezzard Denis Le Bihan Eric C. Wong Educational ObjectivesUpon completion of this course, participants should be able to Describe the current theoretical models for the hemodynamic response to brain activation. Identify those physiological parameters which are accessible to MR measurement. Explain the optimum experimental methods for accessing these parameters. Describe emerging areas of functional MRI methodology. 07:00 Introduction and Course Overview 07:10 A Model for Hemodynamic Response to Brain ActivityRichard B. Buxton 07:30 Numerical Modeling of the BOLD ResponseRichard P. Kennan 07:50 Discussion MORNING CATEGORICAL COURSEImaging in Sports Medicine Lomond 07:00 - 08:00Chairs: Garry E. Gold Juerg Hodler Educational ObjectivesUpon completion of this course, participants should be able to Use MRI findings to identify mechanisms of joint injury and improve their diagnosis of sports-related abnormalities. Tailor MRI protocols to address sports-related musculoskeletal injuries. Explain the role of MR arthrography in the evaluation of intro-articular injuries. Assess the clinical relevance of sports injuries and correlate MRI findings with surgical treatments. Distinguish trauma-related bone and muscle injuries from neoplastic lesions. 07:00 Foot and Ankle InjuriesMark Schweitzer 07:25 Stress Injuries in RunnersGabrielle Bergman 07:50 Discussion MORNING CATEGORICAL COURSEImage Reconstruction Forth 07:00 - 08:00Chair: Michael H. Buonocore Educational ObjectivesUpon completion of this course, participants should be able to Describe gridding theory and compare different gridding techniques. Describe the hardware used in real-time imaging. Explain reconstruction techniques used when the usual amount of data is not available. Describe specialized techniques to correct for system imperfections and to reduce effects of noise. The final five minutes of each talk will be reserved for questions. Gridding Theory and Methods 07:00 Introduction; Choice of Convolution Kernels, Artifacts vs SpeedPeter Boernert 07:30 Data Weighting, SNR, Resolution and Aliasing IssueJames G. Pipe PLENARY LECTURESChallenges to MR Clyde Auditorium 08:15 - 09:30Chairs: Jörg F. Debatin J. Thomas Vaughan Educational ObjectivesWith regard to ultrasound, X-ray computerized tomography and PET techniques, upon completion of this session, participants should be able to Describe the theory and operation of each modality. Describe the principal capabilities of each modality in the clinical setting. List significant biomedical questions that are uniquely answered by each modality. List current areas of research and development in each modality. Identify apparent strengths and weaknesses of each modality relative to MR. 8:15 157. Computed Tomography - Faster and Ever Faster Willi A. Kalender University Erlangen-Nuernberg, Erlangen, Germany. 8:40 158. PET - The Future Will Lie in Improved Sensitivity and Specificity Terry Jones Cheshire, England, UK. 9:05 159.Ultrasound in the New Millennium Thomas Nelson 1University of California, San Diego, San Diego, CA, USA. Diffusion MRI Acquisition Methods Clyde Auditorium 10:30 - 12:30Chairs: David Alsop Susumu M. Mori 10:30 160.Diffusion Tensor Imaging using SENSE-single-shot EPI R. Bammer1, S.L. Keeling1, M. Auer1, K.P. Pruessmann2, P. Roeschmann3, R. Stollberger1, H.P. Hartung1, F. Fazekas1 1University of Graz, Graz, Austria; 2ETH Zurich, Zurich, Switzerland; 3Philips Research Laboratory, Hamburg, Germany. 10:42 161.Improved Diffusion-Weighted Single-Shot EPI in Stroke Using SENSE R. Bammer1, S. L. Keeling1, M. Augustin1, K.P. Pruessmann2, C. Leussler3, F. Ebner1, F. Fazekas1 1University of Graz, Graz, Austria; 2ETH Zurich, Zurich, Switzerland; 3Philips Research Laboratory, Hamburg, Germany. 10:54 162.Mixed-CPMG FSE James G. Pipe1 1Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. 11:06 163.Mapping of the Cortical White Matter by Sub-millimeter 3D-DTI Xavier Golay1, Peter C. Van Zijl1, Susumu Mori1 1Kennedy Krieger Institute & Johns Hopkins University, Baltimore, MD, USA. 11:18 164.Online Motion Correction for Diffusion Weighted Imaging Using Navigator Echoes: Application to RARE Imaging Without Sensitivity Loss David Norris1, Wolfgang Driesel1 1MPI for Cognitive Neuroscience, Leipzig, Germany. 11:30 165.High Resolution MRI from 2D and 3D Superresolution Applied to Single-Shot Images Sharon Peled1, Hayit Greenspan2, Gal Oz2, Yehezkel Yeshurun2, Nahum Kiryati2 1Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; 2Tel Aviv University, Tel Aviv, Israel. 11:42 166.Multishot Diffusion Weighted FSE with PROPELLER James G. Pipe1 1Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. 11:54 167.In Vivo Mapping of the Fast and Slow Diffusion Tensors in Human Brain Christopher Clark1, Maj Hedehus1, Michael E. Moseley1 1Stanford University, Stanford, CA, USA. 12:06 168.In Vivo Axial DTI of the Human Spinal Cord Claudia Wheeler-Kingshott1, Geoffrey Parker1, S. J. Hickman1, Mark Symms2, D. H. Miller1, Gareth Barker1 1Institute of Neurology, London, UK; 2National Society for Epilepsy, Gerrards Cross, England, UK. 12:18 169.Minimizing Distortions and Blurring in Diffusion Weighted Single Shot EPI using High Performance Gradients in Combination with Parallel Imaging Robin Heidemann1, Mark Griswold1, David Porter2, Berthold Kiefer2, Mathias Nittka2, Jianmin Wang2, Axel Haase1, Peter Jakob1 1Universität Würzburg, Würzburg, Germany; 2Siemens Medical Systems, Erlangen, Germany; Technical Developments in Coronary MR Angiography Lomond 10:30 - 12:30Chairs: Debiao Li Mark B.M. Hofman 10:30 170.High-Resolution 3D Fast Spin-Echo Black-Blood Coronary MRA Matthias Stuber1, René M. Botnar1, Elmar Spuentrup2, Warren J. Manning2 1Beth Israel Deaconess Medical Center, Philips Medical Systems, Boston, MA, USA; 2Beth Israel Deaconess Medical Center, Boston, MA, USA. 10:42 171.Coronary MRA with Synchronised Respiratory and Cardiac Motion Using an External Respirator Reduces Scan Times and Improves Navigator Efficiency Sven Plein1, Timothy Norman Bloomer1, John P. Ridgway1, Tim R. Jones1, Zamir Hayek2, Mohan U. Sivananthan1 1Leeds General Infirmary, Leeds, England, UK; 2Medivent Ltd, London, UK. 10:54 172.Coronary Artery Motion with the Respiratory Cycle during Breath-holding and Free-breathing: Implications for Slice-Followed Coronary Artery Imaging Jennifer Keegan1, Peter Gatehouse1, Guang-Zhong Yang1, David N. Firmin1 1Royal Brompton Hospital, London, UK. 11:06 173.A Novel Navigator Technique for Fast and Direct Detection of 3D Displacement of the Coronary Arteries Thanh D. Nguyen1, Yi Wang1, Martin R. Prince1 1Cornell University, Weill Medical College, New York, NY, USA. 11:18 174.Self-Navigated Coronary Artery MR Angiography Christopher J. Hardy1, Manojkumar Saranathan2, Lei Zhao3, Ferenc Jolesz3, Kent Yucel3 1GE Corporate Research & Development, Schenectady, NY, USA; 2GE Medical Systems, Waukesha, WI, USA; 3Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. 11:30 175.Non-ECG-Triggered, High-Resolution, Coronary Artery Imaging using Adaptive Averaging with Real-Time Variable-Density Spirals M.S. Sussman, G.A. Wright1 1Sunnybrook and Women's College Health Science Centre, University of Toronto, Toronto, Ontario, Canada. 11:42 176.Realtime MR with Physiological Monitoring For Improved Scan Localization Jeffrey A. Stainsby1, Tzvi Goldman1, Marshall S. Sussman1, Graham A. Wright1 1Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Canada. 11:54 177.Three-Dimensional Projection Coronary Magnetic Resonance Angiograpy Matthias Stuber1, Peter Börnert2, Elmar Spuentrup3, René M. Botnar1, Warren J. Manning3 1Beth Israel Deaconess Medical Center, Philips Medical Systems, Boston, MA, USA; 2Philips Research Laboratories, Hamburg, Germany; 3Beth Israel Deaconess Medical Center, Boston, MA, USA. 12:06 178.First Experience with Quantitative 3D Phase Contrast Coronary Angiography Steffen Ringgaard1, Jesper Elliot Petersen1, Erik Morre Pedersen1 1Aarhus University Hospital, Aarhus, Denmark. 12:18 179.Ex Vivo MR Contrast-Enhanced Cardiac Imaging In a Stenosis Animal Model: Comparison Between 1.5T and 3T Jie Zheng1, Pamela Woodard1, Dana R. Abendschein1, Friedrich Michael Cavagna2, Nikolaos Tsekos1, Robert J. Gropler1 1Washington University School of Medicine, St. Louis, MO, USA; 2Imaging Department, Milano, Italy. CLINICAL CATEGORICAL COURSEOncologic MR Imaging Hall 2 10:30 - 12:30Chairs: Jelle O. Barentsz Jeffrey L. Evelhoch Educational ObjectivesUpon completion of this course, participants should be able to Apply state-of-the-art methodology for the detection and staging of cancer. Describe the benefits of using USIOP for detection of nodal metastases. Explain how MR can be used to improve response assessment. Appraise the potential for spectroscopic imaging to increase the utility of MR in oncology. 10:30 Cancer Detection and StagingMitchell D. Schnall 10:55 Detection of Nodal MetastasesJelle O. Barentsz 11:20 Response AssessmentAnwar R. Padhani 11:45 Role of Spectroscopic ImagingHedvig Hricak 12:10 Discussion MR Imaging of the Thorax Hall 5 10:30 - 12:30Chairs: Mitchell Albert Hiroto Hatabu 10:30 180.Young Investigator Awards Finalist: Dynamic Spiral MR Imaging of the Lung Using Hyperpolarized 3He: Initial Experience in Healthy and Diseased Lungs Michael Salerno1, Talissa A. Altes1, James R. Brookeman1, Eduard E. De Lange1, John P. Mugler III1 1University of Virginia, School of Medicine, Charlottesville, VA, USA. 10:50 181.Hyperpolarized Helium-3 MR Imaging of Methacholine Challenge Testing in Asthmatics Talissa Altes1, Saba Samee1, Michael Salerno1, Bennett A. Alford1, Jaime Mata1, Ashok Menon2, James R. Brookeman1, Thomas A.E. Platts-Mills1, Eduard E. De Lange1 1University of Virginia, Charlottesville, VA, USA; 2IGC-Medical Advances, Milwaukee, WI, USA. 11:02 182.MR Ventilation Imaging: A Comparison of Hyperpolarized 3He and O2 Shella D Keilholz-George1, Jack Knight-Scott1, John Christopher1, Talissa Altes1, Stuart S Berr1, Eduard E. De Lange1 1University of Virginia, Charlottesville, VA, USA. 11:14 183.Effects of Lipopolysaccharide (LPS) Challenge in the Rat Lung Assessed Non-Invasively by MRI Nicolau Beckmann1, Bruno Tigani1, Rosemary Sugar1, Alan Jackson1, Rene Borer1, Lazzaro Mazzoni1, John Fozard1 1Novartis Pharma, Ltd., Basel, Switzerland. 11:26 184.To Elucidate the Physiology of Liquid Ventilation: Measurments of Alveolar pO2 Using 19F-MRI Claus Peter Heussel1, Alexander Scholz1, Marc Schmittner2, Simone Laukemper-Ostendorf1, Katja Buerger1, Wolfgang Schreiber1, Iris Morgenstern1, Klaus Markstaller3, M Quintel1, Norbert Weiler1, Balthasar Eberle1, Manfred Thelen1, Hans-Ulrich Kauczor3 1Johannes Gutenberg-University, Mainz, Germany; 2University Hospital Mannheim, Mannheim, Germany; 3University of Mainz, Mainz, Germany. 11:38 185.Ventilation Abnormalities and Diffusion Coefficients in the Lungs of Asymptomatic Smokers Jason Leawoods1, Dmitriy A. Yablonskiy1, David Gierada1, Mark S. Conradi1 1Washington University, St. Louis, MO, USA. 11:50 186.Absolute Quantification of Pulmonary Perfusion Using Dynamic T1 Contrast Enhanced MRI: Estimation of Regional Pulmonary Blood Flow (rPBF) and Blood Volume (rPBV). Magalie Viallon1, Wolfgang Schreiber1, Claus Peter Heussel1, Oliver Mohrs1, Melanie Schmitt1, Klaus Kurt Gast1, Balthazar Eberle1, Manfred Thelen1, Hanz-Ulrich Kauczor1 1Johannes Gutenberg Universität, Mainz, Germany. 12:02 187.MR Perfusion Imaging of Pulmonary Diseases Using Arterial Spin Labeling Technique FAIRER Vu M. Mai1, Qun Chen1, Alexander Bankier2, Michael Blake2, Mary Keogan2, Robert R. Edelman1 1Evanston Northwestern Healthcare, Evanston, IL, USA; 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 12:14 188.Three-Dimensional Tracking of Chest Wall Deformation during Cardiopulmonary Resuscitation using Tagged MRI Hillary Kaye Huszar1, Cengizhan Ozturk1, Guy Shechter1, Henry R. Halperin1, Albert C. Lardo1 1Johns Hopkins School of Medicine, Baltimore, MD. USA. Gastrointestinal MR Imaging Hall 1 10:30 - 12:30Chairs: Richard Semelka Carlo Catalano 10:30 189.Faecal Tagging: a New Strategy to Obviate Bowel Cleansing Before MR Colonography Thomas Lauenstein1, Dietmar Schönfelder1, Silke Bosk1, Jörg F. Debatin1 1University Hospital Essen, Essen, Germany. 10:42 190.Small Bowel MRI: Comparison of Water and Polyethylene Glycol as Oral Contrast Media Rohit Sood1, Ilse Joubert1, Hilary Franklin1, Terence C. Doyle2, David J. Lomas1 1University of Cambridge, Addenbrooke's Hospital, Cambridge, England, UK; 2University of Otago, Dunedin, New Zealand. 10:54 191.Real-time Assessment of Pharmacologically induced Changes in Gastric Motility with MRI: a Comparison with Barostat. Ingrid M. de Zwart1, Banafsche Mearadji1, Hildo Lamb1, Ad A.M. Masclee1, Albert De Roos1, Patrik Kunz1 1Leiden University Medical Center, Leiden, Netherlands. 11:06 192.Magnetic Resonance Imaging of the Crohn´s Disease Vicente Sanjuan1, Javier Sempere, Vicente Miranda, JC Martinez, Jose Lopez Mut, Iciar Puchades, Sara Roch, Alicia Tome, Enrique Medina, Julian Celma 1Hospital General Valencia, Valencia, Spain. 11:18 193.Evaluation of Gastric Emptying and Peristalsis by Projection Imaging with Single Shot Half-Fourier RARE Rohit Sood1, Clare Sims1, Lesley Hearn1, Malek Makki1, Martin Graves1, David J. Lomas1 1University of Cambridge, Addenbrooke's Hospital, Cambridge, England, UK. 11:30 194.Non-invasive Distension of the Small Bowel for Optimized Magnetic Resonance Imaging. Michael A Patak1, John M Froehlich1, Constantin Von Weymarn1, Marc A Ritz1, Christoph L Zollikofer1, Klaus Wentz1 1Kantonsspital Winterthur, Winterthur, Switzerland. 11:42 195.3D MR Colonography after Exclusive Intravenous Administration of a Hepatobiliary Contrast Agent Michael V. Knopp1, Frederik Giesel2, Jannis Radeleff2, Hendrik von Tengg-Kobligk2 1National Institutes of Health, Bethesda, MD, USA; 2German Cancer Research Center, Heidelberg, Germany. 11:54 196.MR-Imaging of Gastric Emptying Induced by Erythromycin Thomas Lauenstein1, Jörg Barkhausen1, Mathias Goyen1, Stefan G Ruehm1, Jörg F Debatin1 1University Hospital Essen, Essen, Germany. 12:06 197.Multiplanar Reconstruction of 3D Half-Fourier RARE Images for the Assessment of Extramural Invasion of Rectal Cancer Satoru Nakano1, Hirofumi Asakura1, Yasutane Mori1, Yoshihiro Toyama1, Ichiro Hino1, Motoomi Ohkawa1, Yuichi Yamashita2, Satoshi Sugiura3 1Kagawa Medical University, Kagawa Japan; 2Toshiba Medical Inc., Japan; 3Toshiba Corp. Medical R&D Center, Otawara, Tochigi Japan. 12:18 198.Anovaginal Fistulas: A Spectrum of Abnormalities at MR imaging Soendersing Dwarkasing1, Shahid Hussain2 1Erasmus University Medical Center, Rotterdam, Netherlands; 2Heeze, Netherlands. MR Spectroscopy Applications Forth 10:30 - 12:30Chairs: Ognen A.C. Petroff William D. Rooney 10:30 199.In Vivo Detection of Gene Expression in Liver by 31P Nuclear Magnetic Resonance Spectroscopy Employing Creatine Kinase as a Marker Gene Zhou R.1, A. Auricchio1, J. M. Wilson1, Jerry Glickson1 1University of Pennsylvania, Philadelphia, PA, USA. 10:42 200.In Vivo 31P Evaluation of Cold/Solid Thyroid Nodules Rama Jayasundar1 1All India Institute of Medical Sciences, New Delhi, India. 10:54 201.Identification of Hydroxyl Ion in Bone Mineral Using Solid State Two Dimensional 1H–31P Heteronuclear Correlation NMR Spectroscopy Gyunggoo Cho1, Jerome Ackerman1 1Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. 11:06 202.Simultaneous Water and Fat Suppression in Breast MRS Using Spectral/Spatial PRESS Lawrence Ryner1, Louis Lauzon2 1The National Research Council, Winnipeg, MB, Canada; 2GE Yokogawa Medical Systems, Tokyo Japan. 11:18 203.Effects of High versus Low Fatty Acid Levels During Hyperinsulinemia by Measuring Relative Intromycellular and Extramyocellular Triglyceride Levels with Proton Magnetic Resonance Spectroscopy in Normal Subjects Susan K. Lemieux1, Guenther H. Boden2 1WVU Health Sciences Center, Morgantown, WV, USA; 2Temple University, School of Medicine, Philadelphia, PA, USA. 11:30 204.The Use of [2-13C] Acetate to Determine the Pathway for Neurotransmitter Glutamate Repletion in the Human Brain Vincent Lebon1, Kitt F. Petersen1, Gary W. Cline1, Jun Shen2, Graeme F. Mason1, Sylvie Dufour1, Kevin L. Behar1, Gerald I. Shulman1, Douglas L. Rothman1 1Yale University, School of Medicine, New Haven, CT, USA; 2Nathan S. Kline Institute, Orangeburg, NY, USA. 11:42 205.In Vivo NMR Measurement of TCA Cycle Rate Alteration Following 3NP intoxication Pierre-Gilles Henry1, Vincent Lebon2, Francoise Vaufrey1, Emmanuel Brouillet1, Philippe Hantraye1, Gilles Bloch1 1CEA-SHFJ, Orsay, France; 2Yale University, Medicine, School of Medicine, New Haven, CT, USA. 11:54 206.Assessment of Hepatic Carbohydrate Metabolism in vivo by 3D-localized 13C NMR: The Role of fructose-2,6-bisphosphate in Regulation of Glucose Fluxes in Mice In-Young Choi1, Chaodong Wu1, David A. Okar1, Alex J. Lange1, Rolf Gruetter1 1University of Minnesota, Minneapolis, MN, USA. 12:06 207.13C MRS Correlates with Clinical Severity of Hepatic Encephalopathy BD Ross1, A Moreno-Torres1, J-H Hwang1, J Korula2, C Lowe2, S Bluml1 1Huntington Medical Research Institutes, Pasadena, CA, USA; 2University Hospital, University of Southern California, Los Angeles, CA USA. 12:18 208.Correlation between Cerebral Proton MRS and Psychometry in Patients with Chronic Hepatitis C Infection Daniel M Forton1, Joanna M Allsop1, Glyn A Coutts1, Nicholas Hargarden Dr2, Howard C Thomas3, Simon D. Taylor-Robinson3 1Imperial College School of Medicine, Hammersmith Hospital, London, UK; 2CDR Limited, Reading, Berkshire, England, UK; 3Imperial College School of Medicine, St Mary's Hospital, London, UK. Spectroscopic Quantitation Alsh 10:30 - 12:30Chairs: Thomas Ernst Danielle Graveron-Demilly 10:30 209.A Unified Comparison of Filtering Approaches to Water Peak Suppression in MRS Leentje Vanhamme1, Alain Coron2, Paul Van Hecke1, Jean-Pierre Antoine1, Sabine Van Huffel1 1Katholieke Universiteit Leuven, Leuven, Belgium; 2Delft University of Technology, Delft, The Netherlands. 10:42 210.In vivo 13C NMR Measurement of Total Brain Glycogen Concentrations in the Conscious Rat In-Young Choi1, Rolf Gruetter1 1University of Minnesota, Medical School, Minneapolis, MN, USA. 10:54 211.Comparison of Two non-Invasive Approaches for Determination of Gluconeogenesis: In vitro 2H versus In vivo 13C NMR Spectroscopy. Martin Krssak1, Harald Stingl1, Eva Rosian2, Olaf Kunert2, Klaus Zanger2, Werner Waldhäusl1, Ernst Haslinger2, Michael Roden1 1University of Vienna, Wien, Austria; 2University of Graz, Graz, Austria. 11:06 212.T2 Relaxation Study of Water, N-acetylaspartate (NAA)and Creatine (Cr) in Human Brains Using Hahn and Carr-Purcell Spin-Echoes at 4T and 7T Shalom Michaeli1, Michael Garwood1, Xiao-Hong Zhu1, Lance DelaBarre1, Gregor Adriany1, Peter Andersen1, Hellmut Merkle1, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA. 11:18 213.Phosphocreatine has shorter T2* than Creatine in vivo Yong Ke1, Bruce M Cohen1, Fuyuki Hirashima1, Leanne Nassar1, Perry Renshaw1 1McLean Hospital, Harvard Medical School, Belmont, MA, USA. 11:30 214.Quantification of 1H NMR Spectra of the Human Brain using LCModel and Spin Simulations at 7 Tesla Ivan Tkac1, Joonmo Kim1, Kamil Ugurbil1, Rolf Gruetter1 1University of Minnesota, Minneapolis, MN, USA. 11:42 215.A New Method of Determining Spin-Lattice Relaxation Times and Rate Coefficients for a Chemically Exchanging System Using the One-Pulse Experiment C. Galban1, R.G.S. Spencer1 1NIH/National Institute on Aging, Baltimore, MD, USA. 11:54 216.A Rapid Method For Correction of CSF Partial Volume in Quantitative Proton MR Spectroscopic Imaging Alena Horska1, Vince Calhoun1, Peter B. Barker1 1Johns Hopkins University, Baltimore, MD, USA. 12:06 217.Quantitative Spin Echo 31P Spectroscopic Imaging in Human Brain: Determination of the Free Energy of ATP Hydrolysis Hoby Hetherington1, J. H. Lee2, M. K. Sammi2, J. W. Pan3 1Yeshiva University, Albert Einstein College of Medicine, Bronx, NY, USA; 2Brookhaven National Laboratory, Upton, NY, USA; 3Albert Einstein College of Medicine, Bronx, NY, USA. 12:18 218.The In Vivo Detection of Myo-Inosital Using Double Quantum Coherence Filtering at 3T H. Kim1, P. S. Allen1 1University of Alberta, Edmonton, AL, Canada. GOLD CORPORATE MEMBER LUNCHTIME SYMPOSIUM Philips Medical Systems The Magic of Intera Argyll (Moat House) 12:30 – 13:30 BASIC SCIENCE FOCUS SESSION (WITH POSTERS) fMRI: Signal Modeling and New Techniques Clyde Auditorium Tuesday: 13:30 - 15:30 Chairs: Richard B. Buxton Robert Turner Please see page 179 for details. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Elastography Hall 2 Tuesday: 13:30 - 15:30 Chairs: John B. Weaver Michael H. Buonocore Please see page 222 for details. CLINICAL SCIENCE FOCUS SESSIONMyocardial Viability Lomond 13:30 - 15:30Chairs: Robert M. Judd Robert J. Herfkens 13:30 219.Extent of Hyperenhancement After Myocardial Infarction Depends Upon Timing After Contrast C. Joon Choi1, Joseph M. DiMaria1, Frederick H. Epstein1, Jennifer R. Hunter1, Christopher M. Kramer1 1University of Virginia, Charlottesville, VA, USA. 13:40 220.Diagnostic Value of Wall Motion, Perfusion, and Delayed Hyperenhancement in Emergency Room Evaluation of Chest Pain Raymond Yan Kwong1, Anthony Homer Aletras1, Suresh Rekhraj1, Andrew Ernest Arai1 1National Institutes of Health, Bethesda, MD, USA. 13:50 221.Delayed myocardial Enhancement - Correlation to Thallium SPECT and FDG PET Kirsi Lauerma1, Helena Hänninen1, Tuula Janatuinen2, Kari Virtanen1, Sami Soljanlahti1, Pekka Niemi2, Juhani Knuuti2, Hannu J. Aronen1 1Helsinki University Hospital, Helsinki, Finland; 2Turku University, Turku, Finland. 14:00 222.Delayed Myocardial Contrast Enhancement in Patients with Acute Myocardial Infarction: Comparison with Thallium-201 SPECT Imaging Kakuya Kitagawa1, Hajime Sakuma2, Tadanori Hirano1, Kan Takeda2, Ichiro Kadoya1, Katsutoshi Makino1, Shinya Okamoto1 1Matsusaka Central Hospital, Matsusaka, Mie Japan; 2Mie University School of Medicine, Tsu, Mie Japan. 14:10 223.Diffusion Tensor MRI Mapping The Fiber Architecture of Myocardium Post Infarction – Preliminary Experience in Correlation with Viability Map of Tl201-SPECT and Delay-enhanced MRI Ming-Ting Wu1, Wen-Yih Tseng2, Chun-Peng Liu3, Van Wedeen4, Timothy Reese5, Huay-Ben Pan1, Chien-Fang Yang1 1Kaohsiung Veterans General Hospital, School of Medicine, National Yang Ming University, Kaohsiung, Taiwan; 2Center for Optoelectronic Biomedicine, Taipei, Taiwan; 3Department of Medicine; 4Massachusetts General Hospital, Charlestown, HA, USA; 5Harvard University, Boston, MA, USA. 14:20 224.Differentiation of Viable and Non-Viable Myocardium: Comparison of Gd-Based Extracellular and Bloodpool Contrast Materials versus Manganese-Based Contrast Materials in a Rat Myocardial Infarction Model Sebastian Flacke1, John Stacy Allen1, Jonathan M Chia1, Max Adams2, MP Periasamy2, I Kofi Adzamli2, Christine H Lorenz1 1Washington University, St. Louis, MO, USA; 2Mallinckrodt Inc., St. Louis, MO, USA. 14:30 225.Imaging of Myocardial Infarction: Comparison of Magnevist and Gadophrin III in Rabbits Jörg Barkhausen1, Wolfgang Ebert2, Claudia Heyer2, Jorg F Debatin1, Hanns-Joachim Weinmann2 1University Hospital Essen, Essen, Germany; 2Schering AG, Berlin, Germany. 14:40 226.Delayed-Enhancement MRI Reveals Myocardial Fibrosis in Patients with Symptomatic Hypertrophic Cardiomyopathy Scott D. Flamm1, Rollo P. Villareal1, Ramesh Hariharan2, Raja Muthupillai3, Ali G. Massumi1, James M. Wilson1 1Texas Heart Institute, Houston, TX, USA ; 2Baylor College of Medicine, Houston, TX, USA; 3Philips Medical Systems, St. Luke's Episcopal Hospital, Houston, TX, USA. 14:50 227.Delayed Hyperenhancement Detects Myocardial Abnormalities Ralf Wassmuth1, Anthony H Aletras1, David A Begley1, Karen E Bove Bettis1, Kwabena O Agyeman1, Lameh Fananapazir1, Andrew E Arai1 1National Institutes of Health, Bethesda, MD, USA. 15:00 228.Assessment of Myocardial Fibrosis in Hypertrophic Cardiomyopathy with First Pass and Delayed T1 Enhancement P Sipola1, K Lauerma2, J T Kuikka1, E Vanninen1, K Peuhkurinen1, P Jääskeläinen1, M Laakso1, H Manninen1, J Kuusisto1, H J Aronen1 1Kuopio University Hospital, Kuopio, Finland; 2Helsinki University Central Hospital, Helsinki, Finland. 15:10 229.Global Measurement of the Myocardial Perfusion Index: Application to the Assessment of the Incomplete Gd-DTPA Clearance in Rest/Stress Studies of Cardiac Perfusion A Radjenovic1, J P Ridgway1, T N Bloomer1, S Plein1, D M Higgins1, J FM Meaney1, A Kassner2, U M Sivananthan1 1Leeds General Infirmary, Leeds, UK; 2Philips Medical Systems, UK, Leeds, UK. 15:20 230.Phase Sensitive Inversion Recovery for Detecting Myocardial Infarction using Gd-DTPA Delayed Hyper-Enhancement Peter Kellman1, Andrew E. Arai1, Elliot R. McVeigh1, Anthony H. Aletras1 1National Institutes of Health, Bethesda, MD, USA. CLINICAL SCIENCE FOCUS SESSIONBody MRI: Techniques and Liver Hall 5 13:30 - 15:30Chairs: Carlo Bartolozzi David J. Lomas 13:30 231.Real-time TrueFISP Scanning and Continuous Table Movement Allows for a Whole-Body MR Examination in 30 Seconds Jörg Barkhausen1, Harald H Quick1, Thomas Lauenstein1, Mathias Goyen1, Stefan G Ruehm1, Jorg F Debatin1, Mark E Ladd1 1University Hospital Essen, Essen, Germany. 13:40 232.A Breath-hold Three Dimensional True FISP Sequence for Abdominal MRI Qun Chen1, Pippa Storey1, Deborah Levine2, Wei Li1, Robert Edelman1 1Evanston Northwestern Healthcare, Evanston, IL, USA; 2Beth Israel Deaconess Medical Center, Boston, MA, USA. 13:50 233.Continous 2D "Whole Body" Scan with TrueFISP using z-Ramped Phase Encoding (PE) Hans-Peter Fautz1, Klaus Scheffler1, Jürgen Hennig1 1Radiologische Univ. Klinik Freiburg, Freiburg, Germany. 14:00 234.Morphologic and Functional Characterization of Hepatic Lesions: Assessment of Fast Imaging with Steady State Precession (TrueFISP) in Comparison to Half-Fourier Single Shot Fast Spin Echo (HASTE) Christoph U. Herborn1, Florian Vogt1, Stefan G. Ruehm1, Jörg F. Debatin1 1University Hospital Essen, Essen, Germany. 14:10 235.Fat-suppressed T2-weighted MR Imaging of the Liver: Comparison of Respiratory Triggered Fast Spin-Echo, Breath-hold Single-Shot Fast Spin-Echo and Breath-hold Fast-recovery Fast Spin-Echo Sequences Motoyuki Katayama1, Takayuki Masui1, Shigeru Kobayashi1, Tatsuhiko Ito1, Mamoru Takahashi2, Harumi Sakahara3, Atsushi Nozaki4, Hiroyuki Kabasawa4 1Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka Japan; 2Seirei Mikatabara General Hospital, Hamamatsu, Shizuoka Japan; 3Hamamatsu University School of Medicine, Hamamatsu, Shizuoka Japan; 4GE Yokogawa Medical Systems, Hino, Tokyo Japan; 14:20 236.Prospective Comparative Study in the Detection of Small Hepatocellular Carcinoma with Dynamic MR Imaging and Helical Multidetector-row CT Hiraku Yodono1, Yoko Saito1, Taisuke Sasaki1, Hiroyuki Miura1, Yoko Itabashi1, Koichi Shibutani1, Takashi Ohata1, Gerson LM Prado1 1Hirosaki University Hospital, Hirosaki, Aomori Japan. 14:30 237.Mangafodipir trisodium (Mn-DPDP) Enhanced Three-Dimensional MR Imaging of Hepatocelluar Carcinoma: Correlation with Histopathological Findings Rheun-Chuan Lee1, Hui-Cheng Cheng1, Shyh-Haw Tsay1, Gar-Yang Chau1, Jen-Huey Chiang1 1Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan, ROC. 14:40 238.The High Intensity Rim of Focal Nodular Hyperplasia on Contrast-Enhanced MR Imaging in Comparison with Hepatocellular Carcinoma Nagaaki Marugami1, Shinji Hirohashi2, Satoru Kitano2, Kinya Furuichi1, Sachiko Imai1, Hajime Ohishi2, Hideo Uchida2, Matthias Taupitz3, Bernd Hamm4 1Mimumo Hospital, Nara, Japan; 2Nara Medical University, Nara, Japan; 3Berlin, Germany; 4Universitätsklinikum Charité, Humboldt-Universität, Berlin, Germany. 14:50 239.MRI of the Liver: a Comparison of High-dose and Low-dose Ferumoxide Infusion in Patients with Liver Cirrhosis Paul Arnold1, Janice Ward1, Daniel Wilson1, Philip Robinson1 1St.James's Hospital, Leeds Teaching Hospitals, Leeds, UK. 15:00 240.Right Posterior Hepatic Notch Sign: A Simple Diagnostic MR Sign of Cirrhosis Katsuyoshi Ito1, Donald Mitchell2, Myeong-Jin Kim3, Shinji Koike1, Keiko Kishimoto1, Nobuhiko Ogasawara1, Kazuyoshi Suga1, Naofumi Matsunaga1 1Yamaguchi University School of Medicine, Yamaguchi Japan; 2Thomas Jefferson University, Philadelphia, PA, USA; 3Yonsei University College of Medicine, Seoul, Korea. 15:10 241.Total Body Fat Quantification in Newborn Infants by Magnetic Resonance Imaging Tracey AM Harrington1, E Louise Thomas1, Neena Modi1, Gary Frost1, Glyn A Coutts1, Jimmy D Bell1 1Imperial College School of Medicine, Hammersmith Hospital, London, UK. 15:20 242.Fast Magnetic Resonance Imaging in the Evaluation of Pediatric Malignancies. Avi Mazumdar1, Marilyn J. Siegel M.D.1, Vamsidhar Narra1, Lori Luchtman-Jones1, Robert J. Hayashi1 1Washington University School of Medicine, St. Louis, MO, USA. CLINICAL SCIENCE FOCUS SESSIONSpine and Other Musculoskeletal MR Imaging Hall 1 13:30 - 15:30 Chairs: William E. Palmer Lynne S. Steinbach 13:30 243.Whole-Body-MRI with a Rolling Table Platform to Detect Bone Metastases Thomas Lauenstein1, Lutz Freudenberg1, Silke Bosk1, Jörg F. Debatin1, Jörg Barkhausen1 1University Hospital Essen, Essen, Germany. 13:40 244.In Vivo Short Echo Time Imaging of Achilles Tendon Garry E. Gold1, Tishya A.L. Wren1, Krishna Nayak2, Dwight G. Nishimura2, Gary Beaupre1 1Stanford University and Palo Alto VA, Stanford, CA, USA; 2Stanford University, Stanford, CA, USA. 13:50 245.A Study of the Morphology of Lumbar Discs in Sitting and Standing Positions Using a 0.5T Open-Configuration MRI J.F. Roy1, C. Lindsay1, J.M. Mountquin1, M. Dufour1, G. Bouchard1, M. Lamontagne1, P. Montminy1, C. Moisan1 1Centre hospitalier universitaire de Québec, Québec City, Québec Canada. 14:00 246.The Scottish Back Trial - A Pragmatic Multicentre Randomised Comparison of Two Imaging Policies in the Management of Low Back Pain Fiona J Gilbert1, Jane Andrew1, Adrian M Grant1, Douglas Wardlaw for The Scottish Back Trial1 1University of Aberdeen, Aberdeen, Scotland, UK. 14:10 247.MR Imaging of Neural Tissue Transplants in the Injured Human Spinal Cord: 1-Year Follow Up in 7 Subjects Edward D. Wirth III1, Richard G. Fessler2, Paul J. Reier1, Douglas K. Anderson1 1University of Florida, College of Medicine, Gainesville, FL, USA; 2Chicago Institute of Neurosurgery and Neuroresearch, Chicago, IL, USA. 14:20 248.Diffusion Imaging of Cervical Spondylotic Myelopathy Mario Ries1, Ayhan Demir1, Richard Jones1, Chrit Moonen1, Vincent Dousset2 1Université V. S. Bordeaux II, Bordeaux CDX, France; 2CHU Pellegrin, Bordeaux, France. 14:30 249.Early Detection of Lumbar Discitis by MRI D. James Taylor1, Gregory Colin Brown1, Robert J Moore2, Rebecca Walters2, D C Chapple2, D L Goss2, Robert J. Fraser2 1Royal Adelaide Hospital, Adelaide, SA, Australia; 2University of Adelaide, SA, Australia. 14:40 250.Trabecular Bone Volume Fraction Mapping by Low Resolution MR Imaging Maria Fernandez-Seara1, Hee Kwon Song1, Felix Wehrli1 1University of Pennsylvania, Philadelphia, PA, USA. 14:50 251.Digital Topological Analysis of In Vivo MR Microimages of Trabecular Bone Reveals Structural Implications of Bone Loss Felix Wehrli1, Bryon Gomberg1, Punam Saha1, Hee Kwon Song1, Scott N. Huang1 1University of Pennsylvania, Philadelphia, PA, USA. 15:00 252.Quantification of Regional Human Leg Muscle Perfusion Using First-pass Magnetic Resonance Imaging Shuichiro Kaji1, Brian Hargreaves2, Phillip Yang2, Dwight G. Nishimura2, Bob Hu2 1Kawasaki Medical School, Kurashiki, Okayama Japan; 2Stanford University, Stanford, CA, USA. 15:10 253.In Vivo Assessment of Absolute Perfusion in Mouse Hindlimbs with Spin Labeling MRI J. U.G. Streiff1, Karl-Heinz Hiller1, Christiane Waller1, Matthias Nahrendorf1, Frank Wiesmann1, Wolfgang Bauer2, Eberhard Rommel1, Axel Haase1 1Universität Wurzbürg, Würzburg, Germany; 2Klinikum Mannheim, Mannheim, Germany. 15:20 254.Differential Fat Distribution in UCP3 Over-Expressing Transgenic Mice. K Kumar Changani1, Amy P Nicholson1, Alan White1, Torsten Reese1, John C Clapham2 1SmithKline Beecham, The Frythe, Welwyn, Herts, UK; 2SmithKline Beecham, Harlow, Essex, UK. CLINICAL SCIENCE FOCUS SESSIONMR Imaging of Multiple Sclerosis Forth 13:30 - 15:30Chairs: Joseph A. Frank Dirk Petersen 13:30 255.Cortical and Subcortical Reorganization in Patients with Primary Progressive Multiple Sclerosis and Different Motor Impairment: A Functional Magnetic Resonance Imaging Study Maria A Rocca1, Lucia Moiola1, Andrea Falini1, Giuseppe Scotti1, Giancarlo Comi1, Massimo Filippi1 1Scientific Institute H San Raffaele, Milan, Italy. 13:40 256.fMRI Changes in Patients with Relapsing-Remitting MS and No Clinical Disability Maria A Rocca1, Bruno Colombo1, Giancarlo Comi1, Massimo Filippi1 1Scientific Institute H San Raffaele, Milan, Italy. 13:50 257.Combined Use of Magnetization Transfer Ratio and T2 Histograms in Brain Paranchyma, Brain Atrophy Index to Characterize Multiple Sclerosis (MS) Sharmila Majumdar1, D. Grenier1, D. Pelletier1, D. Portnoy1, J. Carballido Gamio1, D. E. Goodkin2, S. J. Nelson1 1University of California, San Francisco, San Francisco, CA, USA; 2Current address: Immunex Pharmaceuticals. 14:00 258.Improved Correlation of MRT Histograms with Disability in Primary Progressive and Relapsing Onset Multiple Sclerosis using Principle Component Analysis Jamshid Dehmeshki1, Paul Stephen Tofts1, S. M. Leary1, Alan P. Thompson1, David H. Miller1 1University College London, Institute of Neurology, London, England, UK. 14:10 259.Fast Measurement of Quantitative MT Parameters in Fixed Multiple Sclerosis Brain Anita Ramani1, Barker G.J.1, Paul Stephen Tofts1 1University College London, Institute of Neurology, London, UK. 14:20 260.Quantitative Analysis of MRI White Matter Signal Abnormalities with High Reproducibility and Accuracy Xingchang Wei1, Simon Warfield1, Kelly H Zou1, William M. Wells III1, Ying Wu1, Xiaoming Li1, Alexandre Guimond1, Mark Anderson1, Randall R. Benson2, Leslie Wolfson2, Ferenc A. Jolesz1, Charles R.G. Guttmann1 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 2University of Connecticut, Farmington, CT, USA. 14:30 261.Enhancement of Multiple Sclerosis Lesions with Ultra-Small Particle Iron Oxide : Phase II Study Vincent Dousset1, Bruno Brochet1, Jean-Marie Caille1, Klaus G Petry2 1Hôpital Pellegrin, Bordeaux, France; 2Université Victor Segalen Bordeaux 2, Bordeaux, France; 14:40 262.Enhancing MS Lesions on MRI Are More Often Non-Periventricular in Distribution Guo-Jun Zhao1, David KB Li1, Donald W Paty1, UBC MS/MRI Research Group1, Spetrim Study Group1 1University of British Columbia, Vancouver, BC, Canada. 14:50 263.Imaging Inflammation: Visualization of Perivascular Cuffing in EAE by Magnetic Resonance Microscopy Paula Gareau1, Allison C Wymore2, Gary P Cofer2, Stephen J Karlik1, G. Allan Johnson2 1The John P. Robarts Research Institute, London, ON, Canada; 2Duke University, Durham, NC, USA. 15:00 264.Differentiation of MS from Other Inflammatory Diseases and Hypoxic Ischaemic Disorders: Additional Value of Spinal MRI J.C.J. Bot1, F. Barkhof1, G. Lycklama A' Nijeholt1, E. Bergers1, D. Van Schaardenburg1, A. Voskuyl1, H. Adler1, J. Pijnenburg1, C. Polman1, E. Vermeulen1, J. Castelijns1 1VU Medical Centre, Amsterdam, Netherlands. 15:10 265.Regional Brain Atrophy in Multiple Sclerosis: Increasing Sensitivity to Differences in Relapsing-Remitting and Secondary-Progressive Disease J. T. Chen1, P. M. Matthews2, D. L. Arnold3, Y. Zhang2, S. M. Smith2 1University of Oxford, Oxford, UK / Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; 2University of Oxford, Oxford, UK; 3McGill University, Montreal Neurological Institute, Montreal, Quebec Canada. 15:20 266.Comparison of Estimated Cerebral Atrophy in RRMS and Healthy Controls using Three MRI Pulse Sequences and Three Intensity Based Segmentation Techniques Joseph Frank1, John Ostuni1, R. Leigh1, B. K. Lewis1, T. Howard1, J. Patel1, D. Pham1, H. McFarland1 1National Institutes of Health, Bethesda, MD, USA. CLINICAL SCIENCE FOCUS SESSIONCancer MR Spectroscopy Alsh 13:30 - 15:30Chairs: Hedvig Hricak Martin O. Leach 13:30 267.Spermine in Normal Epithelial Cells of Human Prostate --- A HRMAS Proton MR Spectroscopy Study Leo Ling Cheng1, C-L. Wu1, A. E. Mallory1, M. R. Smith1, R. G. Gonzalez1 1Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. 13:40 268.Diagnosis of Hepatocellular Carcinoma using Proton Magnetic Resonance Spectroscopy Ex Vivo Uwe Himmelreich1, Robyn Soper2, Ray Somorjai3, Brion Dolenko3, Dorothy Painter2, Cynthia Lean1, Carolyn Mountford1, Peter Russell1 1University of Sydney, Sydney, NSW, Australia; 2Royal Prince Alfred Hospital, Sydney, NSW, Australia; 3National Research Council, Winnipeg, MB, Canada. 13:50 269.1H-MRS Mobile Lipid Localization in Rat Brain Glioma Sonia Zoula1, Gwénaël Herigault1, Régine Farion1, Paul Rijken2, Hans Peters2, Albert Van Der Kogel2, Chantal Rémy1, Michel Decorps1 1Université Joseph Fourier, Grenoble, France; 2University of Nijmegen, Nijmegen, The Netherlands. 14:00 270.1H MRS of Neutral Lipids in Low and High Grade Gliomas, Recurrent Gliomas, Metastases, Lymphomas, Abscesses, and Inflammation Ulrich Pilatus1, Pia Reichel1, Sebastian Herminghaus1, Peter Raab1, Matthias Setzer1, Heinrich Lanfermann1, Friedhelm E Zanella1 1University Frankfurt, Frankfurt, Germany. 14:10 271.Characterization of Brain Tumors Using 1H-NMR Spectroscopy and Self-Organizing Maps: Relevance of Hydrophilic and Lipophilic Metabolites. Olaf Beckonert1, Jürgen Monnerjahn1, Thomas Nägele2, Dieter Leibfritz1 1University of Bremen, Bremen, Germany; 2University Hospital, Tübingen, Germany. 14:20 272.Single Voxel 2D J-resolved Spectroscopy of the in situ Human Prostate Mark Swanson1, Daniel B. Vigneron1, Napapon Sailasuta2, Ralph Hurd2, John Kurhanewicz1 1University of California, San Francisco, San Francisco, CA, USA; 2G. E. Medical Systems Group, Fremont, CA, USA. 14:30 273.Metabolic Classification of Renal Tumors with 1H Magnetic Resonance Spectroscopy: Comparison of Ex Vivo and Localized In Vivo Results Gregory J Metzger1, Lidia S Szczepaniak2, Arthur I Sagalowsky2, David H Ewalt2, Pamela Nurenberg2 1Philips Medical Systems, Dallas, TX, USA; 2University of Texas Southwestern Medical Center, Dallas, TX, USA. 14:40 274.Investigation of the Predictive Value of the Pretreatment Tumor Content of Phosphoethanolamine and Phosphocholine Measured by In Vivo 31P MR Spectroscopy in Non-Hodgkin's Lymphoma in a Multi-Institutional Setting Fernando Arias-Mendoza1, Kristen Zakian2, Marion Stubbs3, David Collins4, Geoffrey Payne4, Truman R. Brown1, Martin O. Leach4, John R. Griffiths3, Jason A. Koutcher2, Jerry Glickson5, Jeffrey L. Evelhoch6, Arend Heerschap7, H. Cecil Charles8, Sarah J. Nelson9, Cooperative Group on MR Applications in Cancer1 1Fox Chase Cancer Center, Philadelphia, PA, USA; 2Memorial Sloan Kettering Cancer Center, New York, NY, USA; 3St George's Hospital Medical School, London, UK; 4Royal Marsden Hospital, Sutton, UK; 5University of Pennsylvania, Philadelphia, PA, USA; 6Wayne State University, Detroit, MI, USA; 7University Hospital Nijmegen, Nijmegen, Netherlands; 8Duke University, Durham, NC, USA; 9University of California, San Francisco, San Francisco, CA USA. 14:50 275.Statistical Classification Strategy (SCS) Analysis of MRS from Biopsies of Barretts Epithelium Sinead Doran1, Greg Falk2, Cynthia Lean1, Jeanette Philips3, Ray Somorjai4, Carolyn Mountford1 1University of Sydney, Sydney, NSW, Australia; 2Strathfield Private Hospital, Sydney, NSW, Australia; 3Royal North Shore Hospital, Sydney, NSW, Australia; 4National Research Council, Winnipeg, MB, Canada. 15:00 276.Pathologic Metabolism of Neuroepithelial Brain Tumors: Prognostic Impact of Total Choline Compounds and Lipids as Measured with In Vivo Proton MR Spectroscopy Sebastian Herminghaus1, Ulrich Pilatus1, Setzer Matthias1, Lang Joseph1, Heinrich Lanfermann1, Seifert Volker1, Zanella Friedhelm E1 1University Hospital, Frankfurt/Main, Frankfurt/Main, Germany. 15:10 277.Sensitivity and Specificity of In Vivo 1H MRS in Management of Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy Mahesh Kumar1, V. Seenu1, N. R. Jagannathan1 1All India Institute of Medical Sciences, New Dehli, India. 15:20 278.Comparison of In Vivo Proton MRS of Pediatric Brain Tumors with Ex Vivo Magic Angle Spinning MRS of Intact Biopsy Tumor Samples Aria Tzika1, Leo Cheng2, Loukas Astrakas1, Maria Zarifi3, Tina Poussaint1, Liliana Goumnerova1, David Zurakowski1, Douglas Anthony2, Gil Gonzalez2 1Children's Hospital, Harvard Medical School, Boston, MA, USA; 2Massachusetts General Hospital, Charlestown, MA, USA; 3Children's Hospital Agia Sofia, Goudi, Athens, Greece. fMRI: Resolution and Characteristics of Signal Clyde Auditorium 16:00 - 18:00Chairs: Joseph B. Mandeville Richard Alan Jones 16:00 279.Neural Correlate of BOLD Functional MRI Dae-Shik Kim1, Itamar Ronen1, Louis J. Toth2, Oldman Cheryl1, Timothy Duong1, Hellmut Merkle1, Seong-Gi Kim1, Kamil Ugurbil1 1University of Minnesota, Minneapolis, MN, USA; 2Harvard Medical School, Boston, MA, USA. 16:12 280.Oxygenation and Hematocrit Dependence of Blood T2 Relaxation at 1.5T M. Johanna Silvennoinen1, Chekesha Clingman2, Xavier Golay2, Risto Kauppinen1, Peter C. Van Zijl2 1University of Kuopio, Kuopio, Finland; 2Johns Hopkins University, Baltimore, MD, USA. 16:24 281.CBV Changes During Functional and CO2 Challenges: Implications for BOLD Calibration Fahmeed Hyder1, Ikuhiro Kida1, Richard P Kennan1, Douglas L Rothman1 1Yale University, New Haven, CT, USA. 16:36 282.The BOLD Post-Stimulus Undershoot: fMRI versus Imaging Spectroscopy Georg Royl1, Christoph Leithner1, Matthias Kohl1, Ute Lindauer1, Ulrich Dirnagl1, Kenneth Kwong2, Joseph B. Mandeville2 1Charité University Hospital Berlin, Germany; 2Massachusetts General Hospital, Charlestown, MA, USA 16:48 283.Combination of fMRI and VEP Recording: The BOLD Response is not a Linear Transform of the Average Neuronal Activity Clemens Janz1, Sven Heinrich1, Jens Kornmayer1, Michael Bach1, Jürgen Hennig1 1University of Freiburg, Freiburg, Germany. 5:00 284.Concurrent Optical Spectroscopy and Measurement of Intrinsic Magnetic Resonance Signal During Anoxia and Hypercapnia in Anaesthetised Rat John Martindale1, Jason Berwick1, Martyn Paley1, John Mayhew1 1University of Sheffield, Sheffield, England, UK. 17:12 285.Synergy from Simultaneously acquired fMRI and Near-infrared Optical Spectroscopy Data Gary Strangman1, Tom Gaudette1, David A. Boas1 1Massachusetts General Hospital, Charlestown, MA, USA. 17:24 286.Spatial Comparison between fMRI and MEG Studies on Human Somatosensory Area J. He1, S. Francis1, A. Hillebrand2, G. R. Barnes2, R. W. Bowtell1, P. L Furlong2, I. E Holliday2, P. G. Morris1 1University of Nottingham, Nottingham, UK; 2University of Aston, Birmingham, UK. 17:36 287.Probing Fast Neuronal Interaction in the Human Ocular Dominate Columns Based on fMRI BOLD Response at 7 Testa Xiao-Hong Zhu1, Xiaoliang Zhang1, Shuangyi Tang1, Seiji Ogawa2, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA; 2Bell Laboratories, Murray Hill, NJ, USA. 17:48 288.BOLD Localization: the Implications of Vascular Architecture Robert Turner1 1University College London, London, UK. Motion & Artifact Correction Lomond 16:00 - 18:00Chairs: Elliot McVeigh Armando Manduca 16:00 289.Young Investigator Awards Finalist: PROPELLER MRI: Clinical Testing of a Novel Technique for Quantification and Compensation of Head Motion Kirsten P Forbes1, James G Pipe1, Roger Bird1, Joseph E Heiserman1 1Barrow Neurological Institute, St Josephs Hospital and Medical Center, Phoenix, AZ, USA. 16:20 290.Artifact Cancellation using SENSE Spatial Array Processing Peter Kellman1, Elliot R. McVeigh1 1National Institutes of Health, Bethesda, MD, USA. 16:32 291.Spherical Navigator Echoes for 3-D Rigid Body Motion Detection Edward Brian Welch1, Armando Manduca1, Roger Grimm1, Heidi Ward1, Clifford R. Jack Jr.1 1Mayo Clinic, Rochester, MN, USA. 16:44 292.Image-based Ghost Correction for General Interleaved EPI Michael H. Buonocore1, David C. Zhu2 1University of California, Davis, Sacramento, CA, USA; 2G. E. Medical Systems, Milwaukee, WI, USA. 16:56 293.A New Phase-based Algorithm for Fast and Accurate Motion Extraction from Navigator Echoes in Magnetic Resonance Angiography Thanh D. Nguyen1, Yi Wang1, Richard Watts1, Martin R. Prince1 1Cornell University, Weill Medical College, New York, NY, USA. 17:08 294.Evaluation of Automatic Elastic Motion Correction in MR Mammography Harald Fischer1, Jürgen Reichenbach2, Matthias Otte1, Jürgen Hennig1 1Universität Freiburg, Freiburg, Germany; 2Universität Jena, Jena, Germany. 17:20 295.Autocorrection for EPI Ghost Intensity Reduction Heidi A. Ward1, Armando Manduca1, Stephen J. Riederer1, Clifford R. Jack Jr1 1Mayo Clinic, Rochester, MN, USA. 17:32 296.A Novel Integrated Motion Correction Algorithm Using Radial Trajectories Ajit Shankaranarayanan1, Michael Wendt2, Jonathan S. Lewin3, Jeffrey L. Duerk1 1Case Western Reserve University, Cleveland, OH, USA; 2Siemens Medical Systems, Iselin, NJ, USA; 3University Hospitals of Cleveland, Cleveland, OH, USA. 17:44 297.Reduction Of Noise Associated With Stimulus Correlated Motion In Event Related Overt Word Production fMRI Studies Kaundinya Gopinath1, Richard W. Briggs1, David Soltysik1, Nathan Himes1, Bruce A. Crosson1 1University of Florida, Gainesville, FL USA. MR PHYSICS AND TECHNIQUES FOR CLINICIANS Hall 2 16:00 - 18:00Chairs: Frank R. Korosec Joseph C. McGowan Educational ObjectivesAt the conclusion of this course, participants should be able to Define and describe the fundamental principles of MR imaging, including spin magnetization, the Larmor relationship, relaxation phenomena, and the process of using the spin magnetization to produce an image. Explain imaging pulse sequences based upon spin and gradient echoes, including fast spin echo and echo planar techniques. Design MR imaging protocols for diagnostic applications considering image contrast, spatial resolution, acquisition time, signal-to-noise ratio, and artifacts. Describe the principles and capabilities of various advanced MR techniques including perfusion and diffusion, functional, interventional, and cardiac MR imaging. 16:00 Spin Echo Imaging, Including Contrast EnhancementPaul S. Tofts 16:40 Gradient Echo ImagingJohn P. Mugler III 17:20 Fast Spin Echo ImagingJoseph C. McGowan MR Angiography Techniques Hall 5 16:00 - 18:00Chairs: Thomas M. Grist Gerhard Laub 16:00 298.Oscillating Dual-Equilibrium Steady State Angrigraphy (ODESSA) William Overall1, Shreyas Vasanawala1, Steven Conolly1, Dwight G. Nishimura1, Bob Hu1 1Stanford University, Stanford, CA, USA. 16:12 299.Exploiting Three Tesla for Circle of Willis and Carotid Artery Time-of-Flight MR Angiography: A Quantitative, Experimental and Theroetical Study Osama Al-Kwifi1, Derek J Emery1, Reka Ferdinandy1, Alan Wilman1 1University of Alberta, Edmonton, AB Canada. 16:24 300.MR Angiography of Intracranial Aneurysms: 3.0T compared with 1.5T Gordon F. Gibbs1, John Huston III1, Matt A. Bernstein1, Norbert G. Campeau1 1Mayo Clinic, Rochester, MN, USA. 16:36 301.Multiple Slab MR Projection Angiography with Subsecond Temporal Resolution R. Strecker1, S. Arnold1, K. Scheffler1, J. Hennig1 1University Hospital, Freiburg, Germany. 16:48 302.Subsecond Contrast-enhanced 3D MR angiography: A New Technique for Dynamic Imaging of the Vasculature James Carr1, Richard Martin McCarthy1, Gerhard Laub2, Scott Pereles1, John Paul Finn1 1Northwestern University Medical School, Chicago, IL, USA; 2Siemens Medical Systems, Inc., Chicago, IL, USA. 17:00 303.Time-Resolved 3D MR Angiography of the Abdomen with a Real-Time System Oliver Wieben1, Thomas Hany1, Walter Block1 1University of Wisconsin-Madison, Madison, WI, USA. 17:12 304.Time-resolved MRA Using Undersampled 3D Projection Imaging (VIPR) Walter Block1, Thomas Hany1, Andrew Barger1 1University of Wisconsin-Madison, Madison, WI, USA. 17:24 305.Improved Lumen Visualization in Metallic Stents and Filters by Reduction of Susceptibility and RF Artifacts Lambertus W. Bartels1, Chris J.G. Bakker1, Jan L. Verwoerd2, Max A. Viergever1 1University Medical Center Utrecht, Utrecht, The Netherlands; 2Philips Nederland B.V, Eindhoven, The Netherlands. 17:36 306.Navigator-Gated Free-Breathing 3D True-FISP Projection MRA of the Renal Arteries with 2D Pencil Beam Aortic Spin Labeling Pulse Elmar Spuentrup1, Warren J. Manning1, Peter Börnert2, Kraig V Kissinger1, Matthias Stuber1 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 2Philips Research Laboratories, Hamburg, Germany. 17:48 307.In Vivo Vascular Imaging with Hyperpolarized 3He in Microspheres Atsushi M. Takahashi1, Laurence W. Hedlund1, Mark S. Chawla1, G. Allan Johnson1 1Duke University Medical Center, Durham, NC, USA. Stroke: Human Studies Hall 1 16:00 - 18:00Chairs: Leif Østergaard Weili Lin 16:00 308.MR Cerebral Metabolic Rate of Oxygen (MR-CMRO2) May Reveal the Functional Status of Brain Tissue in Acute Stroke Patients Weili Lin1, Hongyu An2, Jin-Moo Lee2, Katie Vo2, Azim Celik3, Yueh Lee1, Chung Y. Hsu2 1UNC-Chapel Hill, Chapel Hill, NC, USA; 2Washington University, St. Louis, MO, USA; 3GE Medical Systems, Milwaukee, WI, USA. 16:12 309.The Hemodynamic Response: Tissue Oxygen Concentration and Oxygen Delivery to Brain John Mayhew1, Ying Zheng1, John Martindale1 1University of Sheffield, Sheffield, England, UK. 16:24 310.Relationship Between Apparent Diffusion Coefficient and Absolute Measurements of Cerebral Blood Flow in Acute Stroke Patients Yueh Z. Lee1, Azim Celik2, Jin-Moo Lee3, Katie Vo3, Hui Liu1, Chung Y. Hsu3, Weili Lin1 1University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; 2GE Medical Systems, Milwaukee, WI, USA; 3Washington University, St. Louis, MO, USA. 16:36 311.Severe ADC Decreases Do Not Predict Irreversible Tissue Damage In Humans Jens Fiehler1, Thomas Kucinski1, Mascha Foth1, René Knab1, Volkmar Glauche1, Cornelius Weiller1, Hermann Zeumer1, Joachim Röther1 1University Hospital Eppendorf, Hamburg, Germany. 16:48 312.Temporal Evolution of Apparent Diffusion Coefficient in Subregions of Perfusion Deficit in Human Ischemic Stroke Yawu Liu1, Jari O. Karonen1, Ritva L. Vanninen1, Jussi Perkiö2, Mervi Könönen1, Pauli Vainio1, Seppo Soimakallio1, Hannu J. Aronen1 1Kuopio University Hospital, Kuopio University, Kuopio, Finland; 2Helsinki University Central Hospital, Helsinki, Finland. 17:00 313.Cerebral Blood Volume: Possible Predictor of Clinical Deficit in Acute Stroke Ronda C Ryder1, Andrea Cole-Haskayne1, Robert J Sevick1, Andrew M Demchuk1, Michael D Hill1, Philip A Barber1, Alastair M Buchan1, Richard Frayne1 1University of Calgary, Calgary, Alberta, Canada. 17:12 314.A Strategy towards the Automated Estimation of Stroke Evolution Utilising a Diffusion and Perfusion MRI based Predictive Model Stephen E. Rose1, Mark Griffin1, Jonathan Chalk1, Andrew Janke1, Fernando Zelaya2, Andrew Simmons2, H. S. Markus3, Wendy Strugnell4, David Doddrell1, Geoffrey J. McLachlan1 1University of Queensland, Brisbane, QLD, Australia; 2Institute of Psychiatry, London, England, UK; 3King's College London, London, UK; 4Princess Alexandra Hospital, Brisbane, QLD, Australia. 17:24 315.Identification of Acute Cerebral Ischemic Lesion Clusters in Stroke Patients That Predict Infarction Using Multiparametric MRI ISODATA Analysis Mamatha Pasnoor1, Panayiotis D Mitsias2, Suresh C Patel2, Rabih Hammoud2, Sunitha Santhakumar2, Nikolaos IH Papamitsakis2, Hamid Soltanian-Zadeh3, Michael Jacobs4, Mei Lu2, Donald Peck2, Ibrahim Duhaini2, Michael Chopp2 1Henry Ford Hospital Detroit, Southfield, MI, USA; 2Henry Ford Health System, Detroit, MI, USA; 3Image Analysis Laboratory, Detroit, MI, USA; 4Johns Hopkins University, Reistertown, MD, USA. 17:36 316.Spatial-temporal Cluster Analysis of Serial Diffusion Tensor MRI in Human Cerebral Ischemia Ona Wu1, Lee Schwamm1, Walter J. Koroshetz1, Thomas Benner1, William Copen1, Thierry Huisman1, Ramon Gilberto Gonzalez1, Leif Østergaard1, Vicky W. Pan2, Bruce R. Rosen1, A. Gregory Sorensen1 1Massachusetts General Hospital, Charlestown, MA, USA; 2Massachusetts Institute of Technology, Cambridge, MA, USA. 17:48 317.Combined BOLD fMRI and Transcranial Magnetic Stimulation Study: Evaluation of Ipsilateral Motor Pathway of Stroke Patients Yongmin Chang1, Bong-Soo Han1, Sung-Ho Jang2, Woo-Mok Byun2, Yong-Sun Kim1, Duk-Sik Kang1 1Kyungpook National University Hospital, Chung-Gu, Taegu, Korea; 2YeungNam University, Taegu, Korea. MRI-Guided Thermal Therapies Forth 16:00 - 18:00Chairs: Kim Butts Elmar M. Merkle 16:00 318.MR-Guided Laser-Induced Interstitial Thermotherapy of Liver Tumors in an Interventional 0.5 T MRI System - Technique, Preliminary Results, and Complication Rate in 72 Patients Frank Eickmeyer1, Volkhard U Fiedler1, Frank P Müller1, Christian Schoepp1, Patrick R Verreet1, Hans-Joachim Schwarzmaier1 1Klinikum Krefeld, Krefeld, Germany. 16:12 319.Laser-induced Thermotherapy in Patients with Hepatic Metastases: Effect of Blood Flow Reduction on Lesion Diameter Frank K. Wacker1, Klaus Reither1, Joerg P Ritz1, Frank Brehm1, Andre Roggan2, Verena Knappe2, Christoph T Germer1, Karl-Juergen Wolf1 1Universitaetsklinikum Benjamin Franklin, FU Berlin, Radiologische Klinik, Berlin, Germany; 2LMTZ, Berlin, Germany. 16:24 320.Noninvasive MRI-Guided Focal Opening of Blood Brain Barrier: Kullervo H. Hynynen1, Nathan Mcdannold2, Natalia Vykhodtseva3, Ferenc A. Jolesz3 1Harvard University, Harvard Medical School, Boston, MA, USA; 2Harvard University, Roxburg, MA, USA; 3Brigham and Women's Hospital, Boston, MA, USA. 16:36 321.A Phase II Clinical Trial of Interactive MR-Guided Interstitial Radiofrequency Thermal Ablation of Primary Kidney Tumors: Preliminary Results Jonathan S. Lewin1, Cindy F. Connell1, Aaron Sulman1, Jeffrey L. Duerk1, Martin I. Resnick1 1University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA. 16:48 322.MR-Guided Radiofrequency (RF) Thermal Ablation Of The Lumbar Vertebrae In A Porcine Model Sherif Gamal Nour1, Andrik Aschoff1, Ian C. Mitchell1, Steven N. Emancipator1, Jeffrey L. Duerk1, Jonathan S. Lewin1 1University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA. 17:00 323.MR-Guided Focused Ultrasound (FUS) : Ablation of VX2 Carcinoma in Rabbit Thigh using a Short Treatment Period Rares Salomir1, Jean Palussiere2, Nicolas Grenier3, Jacco De Zwart, Frederic Vimeux, Bruno Quesson, Chrit Moonen1 1RMSB - UMR5536, Bordeaux, France; 2"Bergonie" Institute, Bordeaux, France; 3CHU Bordeaux, Bordeaux, France. 17:12 324.Paramagnetic Liposomes as Thermosensitive Probes for MRI-Guided Thermal Ablation: Feasibility Study on the Perfused Porcine Kidney K. A. Il'yasov1, A. Bjørnerud2, A. Rogstad2, U. N. Wiggen2, I. Henriksen2, B. Eissner1, J. Hennig1, S. L. Fossheim2 1Freiburg University Hospital, Freiburg, Germany; 2Nycomed Amersham, Oslo, Norway. 17:24 325.Radial MRI - A Motion Insensitive Temperature Mapping Method Tobias Schaeffter1, Steffen Weiss1, Volker Rasche1 1Philips Research, Hamburg, Germany. 17:36 326.MR Guidance of Tumor Ablation in Canine Prostate using a Transurethral Ultrasound Applicator† R. Jason Stafford1, Chris J. Diederich2, Roger E. Price1, Will H. Nau2, Belinda Rivera1, Lars E. Olsson1, John D. Hazle1 1University of Texas M. D. Anderson Cancer Center, Houston, TX, USA; 2University of California, San Francisco, San Francisco, CA, USA. 17:48 327.A New Method for Real-Time Temperature Control During MRI Focused Ultrasound Bruno Quesson1, Frederic Vimeux1, Rares Salomir1, J. Palussiere1, Jacco De Zwart2, Chrit Moonen1 1Université de Bordeaux II, Bordeaux, France; 2Dieren, Netherlands. Musculoskeletal MR Spectroscopy Alsh 16:00 - 18:00Chairs: Chris Boesch Jeroen A.L. Jenesen 16:00 328.Mapping Fiber Orientation in Muscle by Short TE MRSI. Regional Variations of 1H Spectra of Human Muscle Due to Orientation Dependent Dipolar Splittings. Peter Vermathen1, Roland Kreis1, Chris Boesch1 1University & Inselspital, Bern, Switzerland. 16:12 329.Charge Influences Dipolar Coupling Interactions of Lactate and Alanine in Skeletal Muscle Iris Asllani1, Eric Shankland1, Martin J. Kushmerick1 1University of Washington, Seattle, WA, USA. 16:24 330.Determinants of Intramyocellular Lipid Levels are Multifactorial Roland Kreis1, Jacques Decombaz2, Bruno Jung1, Peter Diem1, Michael Ith1, Beat Schmitt1, Hans Hoppeler1, Chris Boesch1 1University & Inselspital, Bern, Switzerland; 2Nestlé Research Center, Nestec Ltd, Lausanne, Switzerland. 16:36 331.Uncoupling Protein-3 Regulates Skeletal Muscle Mitochondrial Oxidative Phosphorylation, in vivo. Gary W. Cline1, Antonio J. Vidal-Puig2, Sylvie Dufour1, Kevin S. Cadman1, Bradford B. Lowell3, Gerald I. Shulman1 1Yale University, School of Medicine, New Haven, CT, USA; 2University of Cambridge, Addenbrooke's Hospital, Cambridge, Cambridge, UK; 3Beth Israel Deaconess Medical Center, Boston, MA, USA. 16:48 332.Assessment of the Rate of Muscle Glycogen Synthesis using 13C Magnetic Resonance Spectroscopy in Zucker fa/fa rats, Zucker lean rats and Sprague Dawley rats: Effect of Treatment with Rosiglitazone Merrill Nuss1, Vincent Hradil1, Yanping Luo1, Sandra Burke1, Eugene Bush1, Robin Shapiro1, Peer Jacobson1, Andy Adler1 1Abbott Labs, Abbott Park, IL USA. 17:00 333.Anaerobic Glycogenolysis is not activated by Calcium Alexander Hsu1, M. Joan Dawson1 1University of Illinois at Urbana-Champaign, Urbana, IL, USA. 17:12 334.A Quantitative Study of Skeletal Muscle Bioenergetics in Muscle Lacking Utrophin and Dystrophin D.J. Taylor1, J. Rafael1, R. Lodi1, M.A. Cole1, Kay Elizabeth Davies1, Peter Styles1 1University of Oxford, Oxford, England, UK. 17:24 335.No Correlation Between Muscle A3243G Mutation Load and Mitochondrial Function In Vivo. A Study of Four Pedigrees. R. Lodi1, D. Taylor2, D. T. Brown3, D. Manners2, P. Styles2, P. F. Chinnery3 1Università di Bologna, Bologna, Italy; 2University of Oxford, Osford, UK; 3The University of Newcastle upon Tyne, UK. 17:36 336.Dynamic Asymmetry of Simultaneously Determined [PCr] and Pulmonary Oxygen Uptake Between the On- and Off-Transients of Moderate Intensity Knee-Extensor Exercise in Humans Harry Rossiter1, Susan Ward2, John Kowalchuk3, Franklyn Howe1, John Griffiths1, Brian Whipp1 1St George's Hospital Medical School, London, UK; 2The University of Glasgow, Glasgow, UK; 3University of Western Ontario, London, Ontario, Canada. 17:48 337.Bioenergetics of Skeletal Muscle in Maternally Inherited Diabetes and Deafness Joost Doornbos1, E. van Essen1, A. de Roos1, A.J. Maassen1, H.H.P.J. Lemkes1 1Leiden University Medical Center, Leiden, Netherlands. BRONZE CORPORATE MEMBER SYMPOSIAToshiba Corporation Lomond 18:15 – 19:45 BRONZE CORPORATE MEMBER SYMPOSIAMallinckrodt, Inc.Advances in Cardiovascular MRI Hall 5 18:15 – 19:45 Advances in Cardiovascular MRI Steven Wolff Martin Prince BRONZE CORPORATE MEMBER SYMPOSIAMarconi Medical Systems Hall 2 18:15 – 19:45 STUDY GROUPMusculoskeletal Imaging Alsh 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 STUDY GROUPDiffusion and Perfusion MR Hall 1 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 STUDY GROUPHigh Field Systems and Applications Forth 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 MORNING CATEGORICAL COURSEEmerging Body MRI Applications Hall 1 07:00 - 08:00 Chairs: Neil M. Rofsky David J. Lomas Educational ObjectivesUpon completion of this course, participants should be able to Recognize the relevance of recent MRI technology developments to diagnostic imaging of the chest, abdomen, and pelvis. Identify the role of fast imaging sequences in body MRI techniques. Describe new imaging applications for evaluating abnormalities of the abdominal and pelvic organs. Implement new protocols for functional imaging of the lung, pancreas, kidney, prostate, and pelvic floor. Recognize the potential value of new methods for interpreting body MRI data. The final five minutes of each talk will be reserved for questions. 07:00 Functional MRCPCelso A. Matos 07:20 Perfusion MR in the PelvisAnwar R. Padhani 07:40 Perfusion MR in the Abdomen Vivian S. Lee MORNING CATEGORICAL COURSEHigh Field Imaging, Spectroscopy, and fMRI Hall 2 07:00 - 08:00Chairs: Arend Heerschap J. Thomas Vaughan Kamil Ugurbil Educational ObjectivesUpon completion of this course, participants should be able to List and explain the advantages of imaging, spectroscopy and fMRI at field strengths of 3T and higher compared to 1.5T and lower. Describe the basic components of a high-field system for clinical imaging and research. Imaging: List clinical imaging methods, applications and research directions enhanced by high-field MRI. Spectroscopy: Appraise spectroscopy as a diagnostic tool at 3T; review research progress at fields to 7T. fMRI: Evaluate the clinical potential of fMRI at 3T and research applications to 7T; explain fMRI contrast mechanisms and their dependency on field strength. Recognize the role(s) of high-field fMRI in the clinic or laboratory. The final 7 minutes of each talk will be reserved for questions. 07:00 Spectroscopy DiagnosticsHoby P. Hetherington 07:30 Spectroscopy ResearchRolf Gruetter MORNING CATEGORICAL COURSEfMRI: What Can We Measure? Hall 5 07:00 - 08:00Chairs: Linda Chang Peter Jezzard Denis Le Bihan Eric C. Wong Educational ObjectivesUpon completion of this course, participants should be able to Describe the current theoretical models for the hemodynamic response to brain activation. Identify those physiological parameters which are accessible to MR measurement. Explain the optimum experimental methods for accessing these parameters. Describe emerging areas of functional MRI methodology. 07:00 Characterizing the Hemodynamic ResponseOliver E.D. Josephs 07:15 Dynamic Measurement of Cerebral Blood FlowEric C. Wong 07:30 Dynamic Measurement of Cerebral Blood VolumeJoseph B. Mandeville 07:45 Discussion MORNING CATEGORICAL COURSEImaging in Sports Medicine Lomond 07:00 - 08:00Chairs: Garry E. Gold Juerg Hodler Educational ObjectivesUpon completion of this course, participants should be able to Use MRI findings to identify mechanisms of joint injury and improve their diagnosis of sports-related abnormalities. Tailor MRI protocols to address sports-related musculoskeletal injuries. Explain the role of MR arthrography in the evaluation of intro-articular injuries. Assess the clinical relevance of sports injuries and correlate MRI findings with surgical treatments. Distinguish trauma-related bone and muscle injuries from neoplastic lesions. 07:00 MRI in Surgical Therapy of Cartilage and ACL InjuriesHollis G. Potter 07:25 Muscle and Tendon InjuriesWilliam E. Palmer 07:50 Discussion MORNING CATEGORICAL COURSEImage Reconstruction Forth 07:00 - 08:00Chair: Michael H. Buonocore Educational ObjectivesUpon completion of this course, participants should be able to Describe gridding theory and compare different gridding techniques. Describe the hardware used in real-time imaging. Explain reconstruction techniques used when the usual amount of data is not available. Describe specialized techniques to correct for system imperfections and to reduce effects of noise. The final five minutes of each talk will be reserved for questions. Hardware and Reconstruction for Real-Time Imaging 07:00 Fluoroscopy and Real-Time Reconstruction ProcessorStephen J. Riederer 07:30 Reconstruction of Data from Multiple CoilsKlaas P. Pruessmann PLENARY LECTURESMR and Aging Clyde Auditorium 08:15 - 09:30Chairs: Mathias Hoehn Chrit MoonenEducational ObjectivesUpon completion of this session, participants should be able to Evaluate the economic and medical implications for MRI of an aging population. Identify technical approaches to enhance patient throughput. Describe how the normal “aged” brain differs from a normal “young” brain. Use various MR techniques to detect disease processes associated with aging in the brain, the cardiovascular system, and the musculoskeletal system. 8:15 338.The Aging Population: A Challenge to MRI? Adrian Kendal Dixon University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. 8:40 339.The Aging Brain Nicholas C. Fox Institute of Neurology, London, UK. 9:05 340.The Aging Body Robert J. Herfkens Stanford University, School of Medicine, Stanford, CA, USA. fMRI: Noise Processes and Signal Recovery Clyde Auditorium 10:30 - 12:30Chairs: Douglas C. Noll Peter Jezzard 10:30 341.Young Investigator Awards Finalist: The Physiological Noise in Oxygenation-Sensitive Magnetic Resonance Imaging Gunnar Krueger1, Gary H. Glover1 1Stanford University, Stanford, CA, USA. 10:50 342.Auto-Regressive Model Order Estimation in Functional MRI Data Shantanu Sarkar1, Essa Yacoub1, William Auffermann1, Shing-Chung Ngan1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 11:02 343.Respiratory Effects in Functional Magnetic Resonance Imaging due to Bulk Susceptibility Changes Devesh Raj1, Derek Paley1, Adam W Anderson1, Richard P Kennan1, John C Gore1 1Yale University, New Haven, CT, USA. 11:14 344.T2* Dependence of Low Frequency Functional Connectivity Scott Peltier1, Douglas Noll1 1University of Michigan, Ann Arbor, MI, USA. 11:26 345.Signal Oscillation in Voxels Containing a Large Venous Vessel and Brain Parenchyma Reflects Blood Oxygen Saturation and Blood Volume Hongyu An1, Weili Lin2 1Washington University, St. Louis, MO, USA; 2UNC at Chapel Hill, Chapel Hill, NC, USA. 11:38 346.Feasibility of Real-Time Auto-Shimming Heidi A. Ward1, Stephen J. Riederer1, Clifford R. Jack Jr1 1Mayo Clinic, Rochester, MN, USA. 11:50 347.Multi-Shot Three-Dimensional Tailored RF Slice-Select Pulses Victor Andrew Stenger1, Fernando Boada1, Douglas Noll2 1University of Pittsburgh, Pittsburgh, PA, USA; 2University of Michigan, Ann Arbor, MI, USA. 12:02 348.Spiral in/out Trajectories for BOLD fMRI Gary H. Glover1, Christine S. Law1 1Stanford University, Stanford, CA, USA. 12:14 349.Single-shot Image Acquisition with Signal Recovery from Susceptibility-Induced Losses Allen Song1 1Duke University, Medical Center, Durham, NC, USA. Animal Brain MRI: New Tricks of the Trade Lomond 10:30 - 12:30Chairs: Jeffrey J. Neil Jens Frahm 10:30 350.Effects of Cellular Swelling on Diffusion in White Matter Greg Stanisz1, R Mark Henkelman1 1University of Toronto, Toronto, ON, Canada. 10:42 351.Ghosts, Phantoms and Spectra: Water Diffusion and Cell Swelling in Diffusion Weighted Imaging Peter E. Thelwall1, Stephen J. Blackband1 1University of Florida Brain Institute, Gainesville, FL, USA. 10:54 352.Measurement of Transmembrane Water Exchange Rate for the in situ Rat Brain James D. Quirk1, G. Larry Bretthorst1, Jeffrey J. Neil1, Joseph J.H. Ackerman1 1Washington University, St. Louis, MO, USA. 11:06 353.Characterization of MRI Lesion Development in a Macrosphere-Induced Embolic Stroke Model Matthew Silva1, Tibo Gerriets2, Fuhai Li2, Marc Fisher2, Christopher Sotak1 1Worcester Polytechnic Institute, Worcester, MA, USA; 2University of Massachusetts Medical School, Worcester, MA, USA. 11:18 354.A New Model for Acute Stroke Therapy Alex J. de Crespigny1, Helen E. D'Arceuil1, Kenneth Maynard1, Noelle Cocoros1, Dan McAuliffe2, Christopher M. Putman1, Ronald F. Budzik1, Alexander Norbash3, Leena Hamberg1, George Hunter1, R. Gilberto Gonzalez1 1Massachusetts General Hospital, Boston, MA, USA; 2CIMIT, Boston, MA, USA; 3Brigham and Women's Hospital, Boston, MA, USA. 11:30 355.Standardization of MRI Tissue Characterization with Histopathological Validation Using Experimental Cerebral Ischemia in Rat H. Soltanian-Zadeh1, M. Pasnoor1, M. A. Jacobs2, R. Hammoud1, M. Lu1, Z. G. Zhang1, R. A. Knight1, A. V. Goussev1, D. J. Peck1, M. Chopp1 1Henry Ford Health System, Detroit, MI USA; 2John Hopkins University, Baltimore, MD, USA. 11:42 356.Measuring Regional Blood Flow in the Rat Brain using Indirect 17O Magnetic Resonance Imaging Dharmesh R. Tailor1, Arijit Roy1, Ravinder R. Regatte1, Sarma V. S. Akella1, John S. Leigh1, Ravinder Reddy1 1University of Pennsylvania School of Medicine, Philadelphia, PA, USA. 11:54 357.On and Off-Resonance T1rð Dispersion in Acute Cerebral Ischemia of the Rat Olli Gröhn1, Heidi Mäkelä1, Jouko Lukkarinen1, Lance Delabarre2, Joseph Lin2, Michael Garwood2, Risto Kauppinen1 1University of Kuopio, Kuopio, Finland; 2University of Minnesota, Minneapolis, MN, USA. 12:06 358.Diffusion Tensor Microimaging of Mouse Brain Development Susumu Mori1, Ryuta Itoh2, Jingyang Zhang1, Walter Erwin Kaufmann1, Peter C. Van Zijl1, Paul Yarowsky3 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2Siga University of Medical Science, Otsu, Shiga Japan; 3University of Maryland, School of Medicine, Baltimore, MD, USA. 12:18 359.In Vivo MR Micro-imaging of Neuronal Migration in the Mouse Brain Daniel H Turnbull1, Youssef Zaim Wadghiri1, Lee Josephson2, Hynek Wichterle3 1NYU School of Medicine, New York, NY, USA; 2Massachusetts General Hospital, Boston, MA, USA; 3Rockefeller University, New York, NY, USA. CLINICAL CATEGORICAL COURSECardiac MR Imaging Hall 2 10:30 - 12:30Chairs: Zahi A. Fayad Christopher M. Kramer Educational Objectives: Upon completion of this course, participants should be able to Describe basic areas of routine and promising use of clinical MR in assessing cardiovascular disease. Describe methodology and interpret results for MR assessment of acquired and congenital heart disease. Apply MR protocols for the evaluation of cardiac morphology, function, viability, and blood flow. Compare approaches for optimal presentation and analysis of cardiac MR results. 10:30 Assessment of Myocardial FunctionJörg Barkhausen 10:55 Assessing Myocardial Perfusion and Stress FunctionSteven Wolff 11:20 Determining Myocardial ViabilityJoao A.C. Lima 11:45 Quantitative Image AnalysisElliot R. McVeigh 12:10 Discussion CLINICAL CATEGORICAL COURSEMarrow MR Imaging Hall 5 10:30 - 12:30Chairs: Mark Schweitzer Bruno van de Berg Educational ObjectivesUpon completion of this course, participants should be able to Recognize the patterns of marrow edema and how to discriminate between the different causes of marrow edema. Identify the characteristics of osteomyelitis in the patient who has neuropathic arthropathy. List the different types of traumatic disorders of marrow. Recognize the different patterns of marrow findings in multiple myeloma on MR. 10:30 MR of Osteomyelitis and NeuroarthropathyWilliam B. Morrison 10:55 MR of Traumatic Marrow DisordersMark Schweitzer 11:20 MR of Multiple MyelomaBruno van de Berg 11:45 MR of Marrow – MiscellaneousJohn A. Carrino 12:10 Discussion Renal and Prostate MR Imaging Hall 1 10:30 - 12:30Chairs: Peter L. Choyke Anwar R. Padhani 10:30 360.Effect of Diabetes Mellitus on Renal Medullary Oxygenation as Evaluated by BOLD MRI Pottumarthi V. Prasad1, Aristidis Veves2, Paula Smakowski2, Franklin H. Epstein2 1Evanston Northwestern Healthcare, Northwestern University Medical School, Evanston, IL, USA; 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 10:42 361.In-Vivo Detection of Acute Rejection in Rat Renal Allograft by MR Imaging with Ultrasmall Superparamagnetic Iron Oxide Qing Ye1, Dewen Yang1, Mangay Williams1, Donald Williams1, Charnchai Pluempitiwiriyawej1, Jose M. F. Moura1, Chien Ho1 1Carnegie Mellon University, Pittsburgh, PA, USA. 10:54 362.Diffusion and BOLD-Contrast Imaging in the Kidneys of Diabetic Rats Mario Ries1, Basseau Fabrice2, Benoit Tyndal2, Richard Jones1, Chrit Moonen1, Nicolas Grenier2 1Université Victor Segalen Bordeaux 2, Bordeaux, France; 2Hospital Pellegrin, Bordeaux, France. 11:06 363.Evaluation of Renal Parenchymal Disease in a Rat Model with Magnetic Resonance Elastography Nihar Shah1, Scott Kruse1, John Lieske2, Bernard King1, Richard Ehman1 1Mayo Clinic, Rochester, MN, USA. 11:18 364.The Use of Dynamic MRI to Assess Renal Gd(DTPA) Clearance in Hypertensive and Normotensive Rats Didier Laurent1, Jim Wasvary1, Kevin Poirier1 1Novartis Pharmaceuticals Corporation, Summit, NJ, USA. 11:30 365.Measurement of Renal Volumes with Voxel Summation Following Contrast Enhanced 3-Dimensional Fast Spoiled Gradient Recalled Echo Imaging of the Kidneys Curtis Coulam1, D. M. Bouley1, Marcus Alley1, F. Graham Sommer1 1Stanford University, Stanford, CA, USA. 11:42 366.A Novel Approach in Analyzing Dynamic Intrarenal Signals Using USPIO and MRI Ying Sun1, Dewen Yang1, Qing Ye1, Chien Ho1, Jose M. F. Moura1 1Carnegie Mellon University, Pittsburgh, PA, USA. 11:54 367.Quantitative Measurement of Blood Perfusion, GFR and Arterial Vascular Fraction in the Kidney Cortex AM Smith1, R Materne1, BE Van Beers1 1Universite Catholique de Louvain, Brussels, Belgium. 12:06 368.Apparent Diffusion Coefficient of the Normal Prostate Using Tetrahedral Encoded Diffusion Gradients Shantanu Sinha1, Usha Sinha1 1University of California, Los Angeles, Los Angeles, CA, USA. 12:18 369.Comparison of Quantitative T2 Mapping and Diffusion Weighted Imaging in the Normal and Pathologic Prostate Peter Gibbs1, Daniel J Tozer1, Gary P Liney1, Lindsay W Turnbull1 1Hull Royal Infirmary, Hull, England, UK. Flow Quantification Forth 10:30 - 12:30Chairs: Freddy Ståhlberg Sten Oyre 10:30 370.Multi-site Comparison of Accuracy, Linearity and Precision in MR Flow Measurements Paul Summers1, Maria Drangova2, Anastasia Papadaki3, David W Holdsworth2, Brian K. Rutt2 1King's College London, London, UK; 2The John P. Robarts Research Institute, London, Ontario, Canada; 3MagNET, Imperial College, London, UK. 10:42 371.Fast Motion Encoding using Steady State Echoes William Overall1, Dwight G. Nishimura1, Bob Hu1 1Stanford University, Stanford, CA, USA. 10:54 372.One-Shot Fourier Velocity-Encoding Using a Variable-Density Trajectory Julie Sabataitis1, G. T. Luk-Pat1, Bob Hu1, Dwight G. Nishimura1 1Stanford University, Stanford, CA, USA. 11:06 373.Real-time Interactive Duplex MR: Application in Neurovascular Imaging Stephan G Wetzel1, Andrew Tan1, Oliver Heid2, Neil M Rofsky3, Glyn Johnson1, Vivian S Lee1 1NYU Medical Center, New York, NY, USA; 2Siemens, Erlangen, Germany; 3Harvard Medical School, Boston, MA, USA. 11:18 374.Pulse-Wave Velocity Measured in One Heartbeat Using MR Tagging Christopher K. MacGowan1, R. Mark Henkelman2, Michael L. Wood2 1Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; 2S&WCHSC , University of Toronto, Toronto, ON, Canada. 11:30 375.Fast Phase-Contrast Imaging At A Single Time Point - A Feasibility Study Maria Drangova1, Andrew Wheatley2, Daniela Galea1 1The John P. Robarts Research Institute and University of Western Ontario, London, ON Canada; 2The John P. Robarts Research Institute, London, ON, Canada. 11:42 376.Measuring Time-Averaged Velocity with Ungated Spiral and 2DFT Phase-Contrast MR J. B. Park1, B. A. Hargreaves1, Dwight G. Nishimura1 1Stanford University, Stanford, CA, USA. 11:54 377.Microscopic Spin Tagging (MiST) for Flow Imaging Silvia Olt1, P Schmitt1, Florian Fidler1, Axel Haase1, PM Jakob1 1Universität Würzburg, Würzburg, Germany. 12:06 378.Visualization of Flow in the Aorta Using Time-resolved 3D Phase Contrast MRI John-Peder Escobar Kvitting1, Einar Brandt1, Lars Wigström1, Jan Engvall1 1Linköping University, Linköping, Sweden. 12:18 379.Combined MRI and Computational Fluid Dynamics Detailed Investigation of Flow in a Realistic Coronary Artery Bypass Graft Model Y. Papaharilaou1, D.J. Doorly1, S.J. Sherwin1, J. Peiro1, J. Anderson2, B. Sanghera1, N. Watkins1, C.G. Caro1 1Imperial College, London, UK; 2Hammersmith Hospital, London, UK. MR Spectroscopy in Neuropsychiatric Disorders Alsh 10:30 - 12:30Chairs: Perry F. Renshaw Peter B. Barker 10:30 380.Anterior Cingulate Proton MRSI in Unipolar Major Depression: Choline Metabolite Changes During SSRI Discontinuation Marc J. Kaufman1, Michael E. Henry1, Blaise deB. Frederick1, John Hennen1, Rosemond A. Villafuerte1, Eve Stoddard1, Bruce M. Cohen1, Perry F. Renshaw1 1McLean Hospital, Harvard Medical School, Belmont, MA, USA. 10:42 381.Evidence of Subtle Prefrontal Neuropathology in Patients with Borderline Personality Disorder. A Pilot Proton Magnetic Resonance Spectroscopy Study. Thorsten Thiel1, Ludger Tebartz Van Elst1, Dieter Ebert1, Jürgen Hennig1 1University Hospital Freiburg, Freiburg, Germany, 10:54 382.Is Voxel Composition and NAA as Measured by 1H MRS Influenced by Structural Abnormalities Associated with Major Depressive Disorder? Bettina Pfleiderer1, Nikolaus Michael1, Patricia Ohrmann1, Andreas Erfurth1, Ulrike Homann1, Volker Arolt1, Walter Heindel1 1University of Münster, Münster, Germany. 11:06 383.Functional Spectroscopic Imaging in Patients with Migraine U. Dydak1, P. S. Sandor2, J. Schoenen3, G. Crelier2, S. S. Kollias2, K. Hess2, R. M. Agosti2, P. Boesiger1 1University and ETH Zurich, Zurich, Switzerland; 2University Hospitals of Zurich, Zurich, Switzerland; 3University Hospitals of Liege, Liege, Belgium. 11:18 384.Measurement of Human Brain (-hydroxybutyrate in Acute Hyperketonemia Jullie W. Pan1, Lee J. H.2, F. W. Telang2, I. Gabriely1, Robin De Graaf3, Manoj K. Sammi2, D. T. Stein1, Douglas L. Rothman3, Hoby Hetherington4 1Albert Einstein College of Medicine, Bronx, NY, USA; 2Brookhaven National Laboratory, Upton, NY USA; 3Yale University, New Haven, CT, USA; 4Yeshiva University, Albert Einstein College of Medicine, Bronx, NY, USA. 11:30 385.Early Proton MRS in Normal Appearing Brain Correlates with Clinical Outcome in a Longitudinal Study of Patients Following Traumatic Brain Injury Matthew Romney Garnett1, Andrew Blamire1, T Ad Codoux-Sudson1, R G Corkill1, Balasubramanian Rajagopalan2, Peter Styles1 1University of Oxford, Oxford, UK ; 2Dept. of Radiological Sciences, Oklahoma City, OK, USA. 11:42 386.1H MRSI Predicts Surgical Outcome in Temporal Lobe Epilepsy Patients with Normal MRI Joyce Suhy1, Kenneth D. Laxer1, Aristides Andres Capizzano1, Peter Vermathen2, Gerald Matson1, Nicholas M. Barbaro1, Michael W. Weiner1 1University of California, San Francisco, San Francisco, CA, USA; 2Inselspital and University, Bern, Switzerland. 11:54 387.A Short Echo Time Proton Magnetic Resonance Spectroscopic Imaging Study of Metabolites in Temporal Lobe Epilepsy. Robert J Simister1, Mary A McLean1, Friedrich G Woermann1, Gareth J Barker2, John S Duncan2 1University College London, Gerrards Cross, UK; 2University College London, London, UK. 12:06 388.Using 1H-MR Spectroscopy in Forensic Medicine to Estimate the Post-Mortem Interval: A Pilot Study in an Animal Model and its Application to Human Brain Michael Ith1, Roland Kreis1, Eva Scheurer2, Richard Dirnhofer2, Chris Boesch1 1University & Inselspital, Bern, Switzerland; 2Inst. of Legal Medicine, University, Bern, Switzerland; 12:18 389.Novel Information Management Methodology for Interactive Reading of over 1000 Magnetic Resonance Spectroscopic Imaging Studies J.R. Alger1, A.J. Frew1, T.F. Cloughesy1, W. del Vecchio1, J.G. Curran1 1UCLA, Los Angeles, CA, USA. GOLD CORPORATE MEMBER LUNCHTIME SYMPOSIUM Siemens Medical Systems, Inc. High Performance MRI Argyll (Moat House) 12:30 – 13:30 BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Spectral Quantification Clyde Auditorium Wednesday: 13:30 - 15:30 Chairs: Truman R. Brown Dirk Van Ormondt Please see page 226 for details. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Data Processing Issues in fMRI Hall 2 Wednesday: 13:30 - 15:30 Chairs: Oliver Speck Nick Lange Please see page 232 for details. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) MRI Safety and Bioeffects Forth Wednesday: 13:30 - 15:30 Chairs: Geoffrey D. Clarke David G. Norris Roger J. Ordidge Please see page 237 for details. CLINICAL SCIENCE FOCUS SESSIONClinical MR Angiography Lomond 13:30 - 15:30Chairs: John Huston Vivian S. Lee 13:30 390.Cost-effective Diagnostic Strategies for Renal Artery Stenosis in Medication Resistant Hypertension: A Decision Analysis Comparing MR Angiography and Conventional Angiography Ruth C. Carlos1, Paul H. Abrahamse1, David A. Axelrod1, A. Mark Fendrick1 1University of Michigan, Ann Arbor, MI, USA. 13:40 391.Motion of the Distal Renal Artery During 3D Contrast-Enhanced Breathhold MRA Boudewijn Vasbinder1, Dave Kaandorp1, Kai Yiu Ho1, Jos van Engelshoven1 1University Hospital Maastricht, Maastricht, The Netherlands. 13:50 392.Preoperative Living Renal Donor Evaluation by MRI John Strang1, Bulent Arslan1, Deborah J. Rubens1, Erdal Erturk1 1University of Rochester, Rochester, NY, USA. 14:00 393.MR-Angiographic Assessment of Vascular Abnormalities and Perfusion Parameters of the Dysfunctioning and Normal Functioning Pancreatic Allograft. R Wolf1, WJ Boeve1, Th Kok1, WJ Sluiter1, RL Kamman1, JJ Homan van der Heide1, RJ Ploeg1, M Oudkerk1 1Groningen University Hospital, Groningen, The Netherlands. 14:10 394.Evaluation of Pediatric Congenital Anomalies of the Aortic Arch with Three-Dimensional Gadolinium-Enhanced Magnetic Resonance Angiography: Comparison with Intraoperative Findings Sabah D. Butty1, Klaus D. Hagspiel1, J. Fritz Angle1, Daniel A. Leung1, Alan H. Matsumoto1, David J. Spinosa1, Irving L. Kron1 1University of Virginia, Charlottesville, VA, USA. 14:20 395.Free Breathing Time Resolved Contrast Enhanced-MRA using SENSE in Pediatric Patients Raja Muthupillai1, G W Vick Iii2, Scott Flamm3, Taylor Chung2 1Philips Medical Systems, St. Luke's Episcopal Hospital, Houston, TX, USA; 2Texas Children's Hospital, Houston, TX, USA; 3St. Luke's Episcopal Hospital, Houston, TX. USA. 14:30 396.High Resolution, Contrast Enhanced MRA: Evaluation of the Entire Carotid Circulation with a Single-Station Acquisition Wyatt C. Jaffe1, Ali Shaibani1, Kenneth Spero1, Elizabeth Krupinski2, Eric J. Russell1, Paul Finn1 1Northwestern University, Chicago, IL, USA; 2University of Arizona, Tuscon, AZ, USA. 14:40 397.Time-Resolved Contrast-Enhanced Carotid MR Angiography Using SENSE Xavier Golay1, Elias R. Melhem1, Ryuta Ito2 1Kennedy Krieger Institute & Johns Hopkins University, Baltimore, MD, USA; 2Johns Hopkins University, Baltimore, MD, USA. 14:50 398.Cardiac-Gated High Spatial Resolution 3D Gd-MRA Technique for the Carotid Arteries Jae K. Kim1, Mathieu Laliberte1, Richard I. Farb2, Rhonda Walcarius2, Graham Wright2 1Sunnybrooke & Women's College Health Science Centre, Toronto, ON, Canada; 2University of Toronto, Toronto, ON, Canada. 15:00 399.Ultra-High Resolution Three-Dimensional Carotid MRA: Validation of ceMRA and MOTSA with CRA Brian K. Rutt1, David W. Holdsworth1, Sandeep Naik2, Donald H. Lee2, Allan J. Fox2, for the Multi-Modality Carotid Subgroup, CIHR Vascular Imaging Research Group1 1The John P. Robarts Research Institute, London, Ontario Canada; 2University of Western Ontario, London, Ontario Canada. 15:10 400.MR Matas Test: Comparison with Conventional Intraarterial Balloon Occlusion Matas Test Masaaki Hori1, Shigeki Aoki2, Toshiyuki Okubo1, Keiichi Ishigame1, Hiroshi Kumagai1, Tsutomu Araki1, Noriko Hirasawa3, Kenji Suzuki3, Touru Hayasaka3 1Yamanashi Medical University, Yamanashi, Japan; 2Tokyo University, Tokyo, Japan; 3GE Yokogawa Medical Systems, Ltd, Tokyo, Japan. 15:20 401.MR Angiography in Patients Treated with GDC Isabel Wanke1, Arnd Doerfler1, Enno Janning1, Carsten Weihl1, Michael Mull2, Armin Thron2, Michael Forsting1 1University of Essen, Essen, Germany; 2Technische Hochschule Aachen, Aachen, Germany. CLINICAL SCIENCE FOCUS SESSIONPediatric Neuro MR Imaging Hall 5 13:30 - 15:30Chairs: Petra S. Hüppi Mary Rutherford 13:30 402.Three-dimensional Modeling and Volume Assessment of the Fetal and Neonatal Intracranial Ventricles Lore Schierlitz1, Petra S. Hüppi2, Marianna Jakab1, Ron Kikinis1, Mary Catherine Frates1, Clare Mc Tempany1, Ferenc A. Jolesz1 1Harvard University, Brigham & Women's Hospital, Boston, MA, USA; 2University of Geneva, Geneva, Switzerland. 13:40 403.Post Mortem Imaging of the Fetal Central Nervous System - Does this Provide Accurate and Valuable Information? Elspeth Helen Whitby1, Martyn Paley1, Margaret J Evans2, Richard Gillott1, Paul David Griffiths1 1University of Sheffield, Sheffield, S Yorks, UK; 2Sheffield Children's Hospital, Sheffield, S Yorks, UK. 13:50 404.Ultrafast Magnetic Resonance Imaging In Utero with Ex Utero Follow Up. Elspeth Helen Whitby1, Martyn Paley1, Susan Rutter1, Michael F Smith2, Alan Sprigg3, Norman Davies2 Iain Wilkinson1, Margaret J Evans3, Kathy Frost1, Paul D Griffiths1 1University of Sheffield, Sheffield, Sheffield, UK; 2Jessop Hospital For Women, Sheffield, UK; 3Sheffield Children's Hospital, Sheffield, UK. 14:00 405.MR Quantification of the Brain in Preterm Infants at Term Equivalent Age Helen J Lewis1, Joanna M Allsop1, Serena J Counsell1, Glyn A Coutts1, Sabrina Larroche1, Mary A Rutherford1 1Imperial College School of Medicine, Hammersmith Hospital, London, UK. 14:10 406.Phys-Maps: Mapping Cardiac and Respiratory Physiological Activity Within the Preterm Infant Brain Gary P. Zientara1, Lawrence P. Panych1, Janet S. Soul2, Joseph J. Volpe2, Ferenc A. Jolesz1 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 2Children's Hospital Boston, Harvard Medical School, Boston, MA, USA. 14:20 407.Early Cerebral Magnetic Resonance Imaging and Ultrasound in Preterm Infants: Prospective Comparison Study Maria J. Miranda1, Peter Born1, Charlotte Strandberg1, Anne-Mette Leffers1, Margrethe Herning1, Hans Lou2, Birgit Peitersen1 1Hvidovre University Hospital, Hvidovre, Denmark; 2The John F. Kennedy Institute, Glostrup, Denmark. 14:30 408.Quantitative MR Demonstration of Altered Brain Development in Newborns following Intrauterine Growth Restriction Petra S. Hüppi1, Slava Zimine2, Francois Lazeyras2, Terrie Inder3, Sylviane Hanquinet2, Simon Warfield4, Ron Kikinis4, Joseph J. Volpe5 1University of Geneva, Children's Hospital, Geneva, Switzerland; 2University Hospital of Geneva, Geneva, Switzerland; 3University of Otago, Christchurch School of Medicine, Christchurch, New Zealand; 4Brigham and Women's Hospital, Boston, MA, USA; 5Children's Hospital of Boston, Harvard Medical School, Boston, MA, USA. 14:40 409.White Matter Maturation in Older Children Demonstrated with Diffusion Tensor MRI Joseph V Philip1, Pratik Mukherjee1, Jeffrey J Neil2, Robert C McKinstry1 1Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA; 2St.Louis Children's Hospital, Washington University, St. Louis, MO, USA. 14:50 410.T2 Relaxation Values in the Developing Preterm Brain Serena J Counsell1, Nigel L Kennea1, Amy H Herlihy1, Joanna M Allsop1, Helen J Lewis1, A David Edwards1, Mary A Rutherford1 1Imperial College, Hammersmith Hospital, London, England, UK. 15:00 411.Diffusion-weighted Imaging (DWI) in Neonates: Relation with Histopathology Ariadne M. Roelants-Van Rijn1, Jeroen Van Der Grond2, Peter G.J. Nikkels2, Floris Groenendaal1, Linda S. De Vries1 1Wilhelmina Children's Hospital, University Medical Center, Utrecht, Netherlands; 2Academic Hospital Utrecht, University Medical Center, Utrecht, Netherlands. 15:10 412.Exploring White Matter Tracts in Band Heterotopia with Diffusion Tractography Sofia Eriksson1, Geoffrey Parker2, Fergus Rugg-Gunn3, Gareth Barker4, Claudia Wheeler-Kingshott5, J. S. Duncan2 1Sahlgrenska University Hospital, Goteborg, Sweden; 2Institute of Neurology, London, England, UK; 3Institute of Neurology, Nat'l Soc. for Epilepsy, Gerrards Cross, England, UK; 4The National Hospital, London, England, UK; 5 Surrey, England, UK. CLINICAL SCIENCE FOCUS SESSIONBody MR Imaging: MRCP Hall 1 13:30 - 15:30Chairs: Riccardo Manfredi Caroline Reinhold 13:30 413.MRCP versus ERCP in the Evaluation of Patients with Suspected Bile Duct Obstruction: A Randomized Clinical Trial Caroline Reinhold1, Naeim Salah1, Alan Nicolas Barkun1, Lawrence Joseph1, Jeffrey S Barkun1, Eric Valois1 1Montréal General Hospital, McGill University, Montreal, Quebec Canada. 13:40 414.Bile Duct Strictures Following Hepatobiliary Surgery: Assessment With Magnetic Resonance Cholangiography Janice Ward1, Maria Sheridan1, Ashley Guthrie1, Mervin Davies1, Charles Millson1, Daniel Wilson1, Philip Robinson1 1St James's Hospital, Leeds Teaching Hospitals, Leeds, UK. 13:50 415.Ability of MR Cholangiography to Demonstrate Stent Position and Luminal Diameter in Patients with Biliary Endoprostheses: In Vitro Measurements and In Vivo Results in 30 Patients Elmar Merkle1 1University of Ulm, Ulm, Germany. 14:00 416.Pitfalls and Optimisation of Breath-hold Single-shot Fast Spin-echo MR Cholangiopancreatography M. A. Schmidt1, G.D. Charles-Edwards1, S. Cleminson1, S. Fleischer-Thompson1, N. Bedford1, S.D. Heenan1 1St George's Hospital, London, UK. 14:10 417.Diagnostic Accuracy MR Cholangiography in Detection of the Common Duct Stones for the Preoperative Evaluation of the Cholelithiasis According to the Clinical Risk Group Myeong-Jin Kim1, Joo-Hee Kim1, Sung-Il Park1, Hyung Sik Yoo1, Jong Tae Lee1 1Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. 14:20 418.Chronic Pancreatitis in Children: Role of Dynamic MRCP after Secretin Administration Riccardo Manfredi1, Benedetta Gui, Vincenzina Lucidi, Maria Gabriella Brizi, Giulia Maresca, Amorino Vecchioli, Pasquale Marano 1Rome, Italy. 14:30 419.Volumetric Mangafodipir-Enhanced MR Cholangiography to Define Intrahepatic Biliary Anatomy Vivian S. Lee1, Glenn A. Krinsky1, Andrew Tan1, Neil M. Rofsky2, Glyn R. Morgan1, Lewis W. Teperman1, Michael T. Lavelle1, Phil Berman1, Jeffrey C. Weinreb1 1New York University Medical Center, New York, NY, USA; 2Harvard Medical School, Boston, MA, USA. 14:40 420.Contrast-Enhanced MRCP: a Comparison of Gd-BOPTA and Mangafodipr. Declan G. Sheppard1, J Graeme Houston1, Jean-Paul Charon1, James S Anderson1, Pat Martin1, Lindsay Allan1 1Ninewells Hospital, Tayside University Hospitals, Dundee, Scotland UK. 14:50 421.High-Resolution MRCP Imaging Using 3D Fast Imaging Employing STeady-state Acquisition (FIESTA) Bernice E. Hoppel1, Robert K. Breger2, Anthony T. Vu1, Tonya J. Hollrith2, Lynda L. Yanny2, Yu Liu2, Thomas K.F. Foo1 1GE Medical Systems, Milwaukee, WI, USA; 2St. Lukes Medical Center, Milwaukee, WI, USA. 15:00 422.Clinical Evaluation of 3D Half-Fourier RARE for MRCP-Portography: Comparison of Short and Long Effective Echo Time RARE Sequence Hiroshi Sugimura1, Kenichiro Yamaguchi1, Yoshio Machida2, S. Kitane2, M. Asato1, Y. Yuki1, E. Ochiai1, R. Ochiai1, S. Tamura1 1Miyazaki Medical College, Miyazaki, Japan; 2Tochigi, Japan. 15:10 423.3D Steady State Free Precession (3D-FIESTA) Imaging of The Pancreaticobiliary Ductal System Hani Marcos1, Vincent B. Ho2, Peter Choyke1, Maureen N. Hood2, Thomas Foo3 1National Institutes of Health, Bethesda, MD, USA; 2Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, MD, USA; 3G. E. Medical Systems, Milwaukee, WI, USA. 15:20 424.Interactive SSFSE-based MR Fluoroscopy of the Abdomen with Real-time Contrast Control Malek Makki1, Martin J. Graves1, David J. Lomas1 1University of Cambridge, Addenbrooke's Hospital, Cambridge, England, UK. CLINICAL SCIENCE FOCUS SESSIONImaging in Psychiatry Alsh 13:30 - 15:30Chairs: Mark A. van Buchem Catriona Good 13:30 425.Detecting Hippocampal Shape Change in Patients At-Risk for Psychosis Stephen Wood1, Geoff Stuart1, Dennis Velakoulis1, Deidre Smith1, Lisa Phillips2, Patrick McGorry2, Patricia Desmond3, Christos Pantelis4 1Mental Health Research Institute, Parkville, Victoria, Australia; 2PACE Clinic, Parkville, Victoria, Australia; 3Royal Melbourne Hospital, Melbourne, Victoria, Australia; 4Sunshine Hospital,, St Albans, Victoria, Australia. 13:40 426.Unbiased Estimation of Fornix and Hippocampal Volume on Co-axial MR Images: Application in the Study of Patients with Organic Amnesia Qi-Yong Gong1, Daniela Montaldi2, Andrew R Mayes2, John Aggleton3, John R Hanley4, Neil Roberts1 1Magnetic Resonance and Image Analysis Research Centre (MARIARC), Liverpool, England, UK; 2University of Liverpool, Liverpool, UK; 3University of Wales, Cardiff, UK; 4University of Essex, UK. 13:50 427.Frontal and Temporal Lobe Brain Volumes in Patients with Idiopathic Parkinson's Disease and Treatment-induced Hallucinations Jacqueline M Graham1, Nigel Hoggard1, Richard A Grünewald1, Paul D Griffiths1 1University of Sheffield, Sheffield, UK. 14:00 428.Alien Voices: Neural Correlates of Impaired Self-Monitoring Associated with Auditory Hallucinations in Schizophrenia Cynthia H.Y. Fu1, Nanda Vythelingum1, Mick J. Brammer1, Chris Andrew1, David Gasston1, Steve Williams1, Edson Amaro Jr1, Philip K. McGuire1 1Institute of Psychiatry, London, UK. 14:10 429.A Twin Study in Schizophrenia: Preliminary Relaxometry Results Vít Herynek1, Monika Dezortová1, Filip Spaniel2, Tomás Hájek2, Milan Hájek1 1Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 2Psychiatric Center, Prague, Czech Republic. 14:20 430.Abnormalities in Corpus Callosum Signal Intensity in Schizophrenia. Vaibhav A. Diwadkar1, Elizabeth L. Dick2, Keith A. Harenski1, Rupali Kotwal1, Michael D. Debellis1, Jay W. Pettegrew2, Matcheri S. Keshavan1 1Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA; 2University of Pittsburgh, Pittsburgh, PA, USA. 14:30 431.Region Specific Effects of Amphetamine on Brain Activation Detected with fMRI S. J. Uftring1, S. R. Wachtel1, D. Chu2, C. Mccandless1, D. N. Levin1, H. De Wit1 1University of Chicago, Chicago, IL, USA; 2Fonar Corporation, Melville, NY, USA. 14:40 432.Regional Distribution of Brain Structural Abnormalities in Chronic Cocaine and Alcohol Abuse Determined by Volumetric MRI Joseph O'Neill1, Valerie A Cardenas1, Dieter J Meyerhoff1 1University of California, San Francisco, San Francisco, CA, USA. 14:50 433.4T fMRI Evaluation of Cerebral Blood Vessel Function in Cocaine-Dependent Subjects Jing-Huei Lee1, F. W. Telang1, Charles Springer1, Nora Volkow2 1Brookhaven National Laboratory, Upton, NY, USA; 2State University of New York at Stony Brook, Stony Brook, NY, USA. 15:00 434.Reduction of Functional Connectivity in the Hippocampus of Chronic Human Cocaine Users Detected by Functional MRI ShiJiang Li1, Amy Kaczmarowski1, Zhu Li1, Gaohong Wu1, Elliot A. Stein1, Hugh Garavan1, Robert Risinger1 1Medical College of Wisconsin, Milwaukee, WI, USA. 15:10 435.A Diagnostic Analysis of Magnetization Transfer Ratio (MTR) Histograms in Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) Patients Jamshid Dehmeshki1, G.P.Th. Bosma2, M. J. Rood2, T. W.J. Huizinga2, Mark Van Buchem2, Paul Stephen Tofts1 1Institute of Neurology, London, England, UK; 2Leiden University Medical Center, Leiden, Netherlands. 15:20 436.Correlation of Apparent Diffusion Coefficient (ADC) Histogram Parameters with Clinical Functioning in Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) G.P.Th. Bosma1, T.W.J. Huizinga1, E.L.E.M. Bollen1, H.A.M. Middelkoop1, M.A. Van Buchem1 1Leiden University Medical Center, Leiden, The Netherlands. Rapid Imaging Clyde Auditorium 16:00 - 18:00Chairs: John Pauly Simon J. Doran 16:00 437.Hyperechoes - Basic Principles and Applications Jürgen Hennig1, Klaus Scheffler1 1University Hospital Freiburg, Freiburg, Germany. 16:12 438.T2-Weighted 3D Spin-Echo Train Imaging of the Brain at 3 Tesla: Reduced Power Deposition Using Low Flip-Angle Refocusing RF Pulses John P. Mugler III1, Lawrence L. Wald2, James R. Brookeman1 1University of Virginia, School of Medicine, Charlottesville, VA, USA; 2Massachusetts General Hospital, Charlestown, MA, USA. 16:24 439.Characterization of the Transient Response in Steady-State Sequences B. A. Hargreaves1, Shreyas Vasanawala1, John M. Pauly1, Dwight G. Nishimura1 1Stanford University, Stanford, CA, USA. 16:36 440.Magnetization Preparation during the Steady State: Fat Saturated 3D TrueFISP Klaus Scheffler1, Oliver Heid2, Jürgen Hennig1 1Universität Freiburg, Freiburg, Germany; 2Siemens Medical Imaging, Erlangen, Germany. 16:48 441.3D True-FISP Imaging with Fat Suppression Walter Block1, Thomas Hany1, Andrew Barger1 1University of Wisconsin-Madison, Madison, WI, USA. 17:00 442.Real-Time Spiral SSFP Cardiac Imaging Craig Meyer1, John M. Pauly1, Krishna Nayak1, Michael Mcconnell1, Albert Macovski1, Dwight G. Nishimura1, Bob Hu1 1Stanford University, Stanford, CA, USA. 17:12 443.Cardiac Imaging using Echo-Planar Steady-State Free Precession Glenn S. Slavin1, Thomas K.F. Foo1 1GE Medical Systems, Milwaukee, WI, USA. 17:24 444.Using UNFOLD to Remove Artifacts in Dynamic Imaging Bruno Madore1 1Harvard University, Boston, MA, USA. 17:36 445.Adaptive Sensitivity Encoding Incorporating Temporal Filtering (TSENSE) Peter Kellman1, Frederick H. Epstein2, Elliot R. McVeigh1 1National Institutes of Health, Bethesda, MD, USA; 2University of Virginia, Charlottesville, VA, USA. 17:48 446.Off-Resonance Artifacts in Single Shot EPI using Partially Parallel Imaging Mark Griswold1, Peter Jakob1, Robin Heidemann1, Mathias Nittka1, Jianmin Wang2, Berthold Kiefer1 1Universität Würzburg, Physikalisches Institut, Würzburg, Germany; 2Siemens Medical Engineering, Erlangen, Germany. Myocardial Tagging and Hemodynamics Lomond 16:00 - 18:00Chairs: Leon Axel John N. Oshinski 16:00 447.Limiting Dilatation Improves Ventricular Function in a Model of Myocardial Infarction as Assessed by Tissue-tagged MRI James J Pilla1, Aaron S Blom1, Daniel J Brockman1, Lawrence Dougherty1, Frank W Bowen1, Joseph Giammarco1, Qing Yuan1, Victor Ferrari1, Michael A Acker1, Leon Axel1 1University of Pennsylvania Medical Center, Philadelphia, PA, USA. 16:12 448.Myocardial Tagging with 3D-CSPAMM Salome Ryf1, Marcus Spiegel1, Oliver M Weber1, Peter Boesiger1 1University and ETH Zurich, Zurich, Switzerland. 16:24 449.MR Tagging of the Entire Cardiac Cycle: Regional Analysis of Normal Subjects and Hypertrophic Cardiomyopathy Using A New Quantity for Assessment of Regional Cardiac Function Daniel B. Ennis1, Frederick H. Epstein2, Elliot R. McVeigh3, Andrew E. Arai3 1Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2University of Virginia, Charlottesville, VA, USA; 3National Institutes of Health, Bethesda, MD, USA. 16:36 450.MRI Tagging in Mice After Acute Myocardial Infarction Demonstrates Heterogeneity of Function in the Non-Infarcted Zone Frederick H. Epstein1, Zequan Yang1, Wesley D. Gilson1, Christopher M. Kramer1, Brent A. French1, Stuart Scott Berr1 1University of Virginia, Charlottesville, VA, USA. 16:48 451.Improved Harmonic Phase (HARP) Instantaneous Myocardial Strain Maps Joost P.A. Kuijer1, Eric Jansen1, J. Tim Marcus1, Robert M. Heethaar1 1University Hospital Vrije Universiteit, Amsterdam, Netherlands. 17:00 452.Relationship Between k-space Trajectory and Artifacts in Breath Held, Gated Segmented k-space Imaging Moriel NessAiver1 1University of Maryland at Baltimore, Baltimore, MD, USA. 17:12 453.Estimation of Time-varying Three-dimensional Relative Pressure Fields within the Human Heart Tino Ebbers1, Lars Wigström1, Ann F Bolger2, Bengt Wranne1, Matts Karlsson1 1Linköping University, Linköping, Sweden; 2University of California San Francisco, San Francisco, CA. USA. 17:24 454.Free Breathing Fourier Velocity Encoded M-Mode MRI for Measurement of Aortic Distensibility Manojkumar Saranathan1, Christopher J. Hardy2, Xuli Zong2, Vincent B. Ho3 1GE Medical Systems, Waukesha, WI, USA; 2GE Corporate Research & Development, Schenectady, NY, USA; 3Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 17:36 455.MRI Assessment of Atrial Septal Defects in Adults Xiuling Qi1, Naeem Merchant2, Fiona Walker2, Gary D. Webb2, Peter McLaughlin2, Jeffrey Stainsby1, Graham Wright1 1Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Canada; 2University Health Network, University of Toronto, Toronto, Canada. 17:48 456.Measurements of Left Ventricular Dimensions and Function using Steady-State Free Precession Imaging: Comparison with Turbo Gradient Echo Imaging Sven Plein1, Timothy N. Bloomer1, John P. Ridgway1, Tim R. Jones1, Gavin J. Bainbridge1, Mohan U. Sivananthan1 1Leeds General Infirmary, Leeds, England, UK. MR PHYSICS AND TECHNIQUES FOR CLINICIANS Hall 2 16:00 - 18:00Chairs: Frank R. Korosec Joseph C. McGowan Educational ObjectivesAt the conclusion of this course, participants should be able to Define and describe the fundamental principles of MR imaging, including spin magnetization, the Larmor relationship, relaxation phenomena, and the process of using the spin magnetization to produce an image. Explain imaging pulse sequences based upon spin and gradient echoes, including fast spin echo and echo planar techniques. Design MR imaging protocols for diagnostic applications considering image contrast, spatial resolution, acquisition time, signal-to-noise ratio, and artifacts. Describe the principles and capabilities of various advanced MR techniques including perfusion and diffusion, functional, interventional, and cardiac MR imaging. 16:00 Image Quality and Acquisition SpeedNorbert J. Pelc 16:40 Echo Planar ImagingMarcus Alley 17:20 Perfusion and Diffusion ImagingScott D. Swanson Animal Brain MRI: Ischemia and Infarction Hall 5 16:00 - 18:00Chairs: Bruce R. Rosen Peter R. Allegrini 16:00 457.Separating MR Changes of Intra- and Extracellular Water in Focal Cerebral Ischemia in the Rat Brain Matthew Silva1, Tsuyoshi Omae2, Karl Helmer1, Fuhai Li2, Marc Fisher2, Christopher Sotak1 1Worcester Polytechnic Institute, Worcester, MA, USA; 2UMass Memorial Health Care, University of Massachusetts Medical School, Worcester, MA, USA. 16:12 458.Mismatch between Lactate and the Apparent Diffusion Coefficient of Water in Progressive Focal Ischemia Toshihiko Ebisu1, Tetsuro Takegami2, Yoshitaka Bito3, Satoshi Hirata3, Yukari Yamamoto3, Masahiro Umeda1, Shoji Naruse2, Chuzo Tanaka1 1Meiji University of Oriental Medicine, Kyoto, Japan; 2Kyoto Prefectural University of Medicine, Kyoto, Japan; 3Hitachi, Ltd., Tokyo, Japan. 16:24 459.Comparison of the Temporal and Spatial Evolution of the Water Apparent Diffusion Coefficient and T2 Following Transient Middle Cerebral Artery Occlusion in Rats Matthew Silva1, Fuhai Li2, Marc Fisher2, Christopher Sotak1 1Worcester Polytechnic Institute, Worcester, MA, USA; 2UMass Memorial Health Care, University of Massachusetts Medical School, Worcester, MA, USA. 16:36 460.Mild Hypothermia Attenuates Cyclooxygenase-2 mRNA Expression and Transient Water ADC Reduction during Permanent Focal Ischemia in Rats Anthony Mancuso1, Nikita Derugin2, Theresa A Marsh3, Kazushi Hara3, Kong L Daniel2, Frank R Sharp4, Philip R. Weinstein2 1University of Pennsylvania, Philadelphia, PA, USA; 2University of California, San Francisco, San Francisco, CA, USA; 3Dept. of Veterans Affairs Medical Center, San Francisco, CA, USA; 4University of Cincinnati, Cincinnati, OH, USA. 16:48 461.Ischaemic Preconditioning in the Rat Brain: A Longitudinal Magnetic Resonance Imaging (MRI) Study. Paul G Mullins1, David G Reid2, Paul Hockings2, Sarah J Hadingham3, Colin A Campbell3, Jonathan Chalk4, David Doddrell4 1University of New Mexico, Albuquerque, NM, USA; 2SmithKline Beecham Pharmaceuticals, Welwyn, England, UK; 3SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK; 4University of Queensland, Brisbane, QLD, Australia. 17:00 462.SB 234551 Improves Cortical Collateral Perfusion Following Permanent MCAO in the Rat Stephen C. Lenhard1, Jeffrey J. Legos1, Robin E. Haimbach1, Ross G. Bentley1, Thomas R. Schaeffer1, Frank C. Barone1, Eliot H. Ohlstein1, Susanta K. Sarkar1, Andrew A. Parsons1, Sudeep Chandra1 1SmithKline Beecham Pharmaceuticals, King of Prussia, PA, USA. 17:12 463.A Comparative Stroke Study between Wild-Type and PARP Transgenic Mice Using Diffusion MRI R. Xue1, S. Goto1, M. Sawada1, P. D. Hurn1, V. L. Dawson1, T. M. Dawson1, R. J. Traystman1, P. C.M. van Zijl1, S. Mori1 1The Johns Hopkins University, School of Medicine, Baltimore, MD, USA. 17:24 464.Delayed rt-PA Treatment Induces Rapid Blood-Brain Barrier Breakdown and Subsequent Hemorrhagic Transformation in a Rat Embolic Stroke Model Rick M. Dijkhuizen1, Minoru Asahi1, Ona Wu1, Bruce R. Rosen1, Eng H. Lo1 1Massachusetts General Hospital, Charlestown, MA, USA. 17:36 465.Topographical Representation of Functional Recovery in the Brain Detected by fMRI Analysis Zhengguang Chen1, Masahiro Abo2, Li-Ju Lai1, Torsten Reese3, Satoshi Miyano2, Kyozo Yonemoto2, Börje Bjelke1 1Karolinska Hospital, Karolinska Institute, Stockholm, Sweden; 2Jikei University School of Medicine, Tokyo, Japan; 3Present address: SmithKline Beecham, Welwyn, Herts, London, UK. 17:48 466.Quantitative Sodium MRI of Evolving Focal Brain Ischemia in the Rat Fernando Boada1, A. Kharlamov2, D. K. Kim2, E. D. Reid1, Ileana Hancu1, S. C. Jones2 1University of Pittsburgh, Pittsburgh, PA, USA; 2Allegheny General Hospital, Pittsburgh, PA, USA. MRS of White Matter and Degenerative Diseases Hall 1 16:00 - 18:00Chairs: Douglas L. Arnold Dorothée P. Auer 16:00 467.Absolute Quantification of Metabolites in White Matter using MR Spectroscopy in Patients with MS or Syndromes Suggestive of MS with Normal MRI Scans of the Brain Maria Gustafsson1, Peter Lundberg1, Anne-Marie Landtblom1 1University Hospital of Linköping, Linköping, Sweden. 16:12 468.Proton MR Spectroscopy with Metabolite-Nulling Reveals Elevated Macromolecules in Acute MS Irina Mader1, Uwe Seeger1, Robert Weissert1, Uwe Klose1, Thomas Naegele1, Arthur Melms1, Wolfgang Grodd1 1Tuebingen University, Tuebingen, Germany. 16:24 469.T2-based Volume Correction for Edema in Single Volume MRS of Contrast-Enhancing Multiple Sclerosis Lesions Gunther Helms1 1Karolinska Institute, Karolinska Hospital, Stockholm, Sweden. 16:36 470.In Vivo 3D 1H MRS of T1-Hypointense Lesions in Relapsing-Remitting Multiple Sclerosis Belinda S.Y. Li1, David M. Moriarty1, Juleiga Regal1, Lois J. Mannon2, Robert I. Grossman2, Oded Gonen1 1Fox Chase Cancer Center, Philadelphia, PA, USA; 2University of Pennsylvania, Philadelphia, PA, USA. 16:48 471.Proton Magnetic Resonance Spectroscopy in Assessing Axonal Loss in the Corpus Callosum Related with Volume of Regional T1 Lesion Load in Multiple Sclerosis Joonmi Oh1, Daniel Pelletier1, Sarah J Nelson1 1University of California San Francisco, San Francisco, CA, USA. 17:00 472.1H MRS and Volumetric MRI Studies of Multiple Sclerosis: Correlations between Brain Metabolite Levels, Brain Atrophy, and Cognitive Functions Wei Huang1, C. Christodoulou1, Dongqing Chen1, Alina Tudorica1, Patricia Roche1, W. Scherl1, R. Peyster1, Clemente Roque1, P. Melville1, V. Geronimo1, Terry M. Button1, Z. Liang1, Lauren Krupp1 1State University of New York at Stony Brook, Stony Brook, NY, USA. 17:12 473.Thalamic Neuronal Loss in Multiple Sclerosis: a Combined Structural and Spectroscopic Study Marzena Wylezinska1, Alberto Cifelli1, Paul Matthews1, Peter Jezzard1 1University of Oxford, John Radcliffe Hospital, Oxford, UK. 17:24 474.Metabolic Differences Between Multiple Sclerosis Subtypes Measured by Quantitative MR Spectroscopy Jullie W. Pan1, Patricia Coyle2, Lauren Krupp2, John N. Whitaker3, K. Bashir3, Hoby Hetherington4 1Albert Einstein College of Medicine, Bronx, NY, USA; 2State University of New York at Stony Brook, Stony Brook, NY, USA; 3University of Alabama at Birmingham, Birmingham, AL, USA; 4Yeshiva University, Albert Einstein College of Medicine, Bronx, NY, USA. 17:36 475.Brain MR Spectroscopy Follow-up in Aging Women and Men Paul E. Sijens1, Tom den Heijer2, Sahra E. Vermeer2, Monique M.M.B. Breteler2, Albert Hofman2, Oudkerk Matthijs1 1University Hospital Groningen, Groningen, Netherlands; 2Erasmus University Medical School, Rotterdam, Netherlands. 17:48 476.Fast Proton MR Spectroscopic Imaging of Temporal Lobe and Hippocampus in Alzheimer's Disease Wolfgang Block1, Frank Träber1, Frank Jessen1, Sebastian Flacke1, Christoph Manka1, Rolf Lamerichs2, Reinhard Heun1, Ewald Keller1, Hans H. Schild1 1University of Bonn, Bonn, Germany; 2Philips Medical Systems, Best, The Netherlands, Tumor Anti-Vascular Therapy Forth 16:00 - 18:00Chairs: John C. Waterton Robert Brasch 16:00 477.Tumor Perfusion Efficiency and Mean Vessel Size Measured in Experimental Human Gliomas Scott D. Packard1, Tomogatsu Ichikawa2, Joseph B. Mandeville3, Ennino. A. Chiocca2, Bruce Rosen3, John J. A. Marota4 1Massachusetts Institute of Technology, Massachusetts General Hospital, Charlestown, MA, USA; 2Massachusetts General Hospital, Boston, MA, USA; 3Harvard University, Massachusetts General Hospital, Charlestown, MA, USA; 4Harvard University Medical School, Boston, MA, USA. 16:12 478.ZD6474, a VEGF Signalling Inhibitor: Effects on DCEMRI in Human Tumour Xenografts and Approaches to the Analysis of the Ktrans Maps David Checkley1, Jean Tessier1, Stephen Wedge1, Michael Dukes1, Jane Kendrew1, John C Waterton1 1Astrazeneca, Macclesfield, Cheshire, UK; 16:24 479.Anti-Angiogenic Agent TNP-470 Significantly Decreases Permeable Regions Zaver M. Bhujwalla1, Dmitri Artemov1, Kshama Natarajan1, Paul E. G. Kristjansen2 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2University of Copenhagen, Copenhagen, Denmark; 16:36 480.A Dynamic Contrast-Enhanced Study of the Effects of the Novel Tumour Vascular Targeting Agent ZD6126 in GH3 Rat Tumours Dominick J.O. Mcintyre1, Simon P. Robinson1, Franklyn A. Howe1, John R. Griffiths1, Jean J. Tessier2, David Checkley2, David C. Blakey2, John C. Waterton2 1St. George's Hospital Medical School, London, UK; 2AstraZeneca, Macclesfield, Cheshire, UK. 16:48 481.Dynamic Contrast-Enhanced MRI Evaluation of the Effects of ZD6126 on Tumor Vasculature Jeffrey L. Evelhoch1, Zhanquan He1, Lisa Polin1, Thomas H. Corbett1, David C Blakey2, John C. Waterton2 1Wayne State University, Detroit, MI, USA; 2Astrazeneca, Alderley Park, Cheshire, England, UK. 17:00 482.Combretastatin Reduces Blood Flow in Animal and Human Tumours, Demonstrated by Dynamic MRI Susan M Galbraith1, Martin Lodge2, N. Jane Taylor2, Ross Maxwell1, Gill M Tozer1, James J Stirling2, Luiza Sena3, Anwar Padhani2, Gordon Rustin2 1Gray Laboratory Cancer Research Trust, Northwood, Middlesex, UK; 2Mount Vernon Hospital, Northwood, Middlesex, UK; 3Drug Development Office, Cancer Research Campaign, UK. 17:12 483.Dynamic Gadolinium-Enhanced MRI Evaluation of Tumor Vascularity in Humans: Determination of Physiologic Parameters and Effects of Combretastatin A4 Phosphate Mark Alan Rosen1, Sarah Englander1, Peter B. O'Dwyer1, James Stevenson1, Mitchell Schnall1 1University of Pennsylvania, Philadelphia, PA, USA. 17:24 484.MRSI of Antiangiogenesis/Radiation in Pediatric Gliomas Loukas Astrakas1, Aria Tzika1, Tina Poussaint1, Marc Kieran2 1Children's Hospital and Harvard Medical School, Boston, MA, USA; 2Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. 17:36 485.Reproducibility of Quantitative Permeability Measurements in Dynamic Contrast-Enhanced MRI Studies Martin A Lodge1, Susan M Galbraith1, N. Jane Taylor1, Ross Maxwell1, J James Stirling1, Hiram Baddeley1, Gordon Js Rustin1, Anwar R. Padhani1 1Mount Vernon Hospital, Northwood, UK. 17:48 486.Reproducibility of Blood Volume and Relative Recirculation Measurements in Cerebral Glioma using T2* Techniques Andrea Kassner1, Xiaoping Zhu2, Ka-Loh Li2, Alan Jackson2 1Philips Medical Systems, Leeds, England, UK; 2University of Manchester, Manchester, England, UK. MR Spectroscopy of Animal Brain Alsh 16:00 - 18:00Chairs: Rolf Gruetter Nicolau Beckmann 16:00 487.Transient Hypoxia Studied By Proton Spectroscopy and Diffusion-Weighted Imaging in Embryonic Chicken Brain In Ovo John Thornton1, Ernest Cady1, Roger Ordidge1, Suzanne Miller1, Donald Peebles1 1University College London, London, UK. 16:12 488.In vivo Quantification of Metabolites in the Hippocampus, Striatum, and Cortex of the Developing Neonatal Rat. Ivan Tkac1, Raghavendra Rao1, Michael K Georgieff1, Rolf Gruetter1 1University of Minnesota, Minneapolis, MN, USA. 16:24 489.Effects of Dexamethasone Pretreatment on Brain and Whole Body Metabolism in a Neonatal Hypoxia-Ischemia Animal Model Jian-li Wang1, Shannon Beabes1, Bernard Dardzinski2, Michael B. Smith1 1Pennsylvania State University, Hershey, PA, USA; 2University of Cincinnati, Cincinnati, OH, USA. 16:36 490.Cellular and Developmental Tissue Distribution of NAA Catabolic Enzyme, Aspartoacylase. Insights into NAA Function. Kishore Bhakoo1, Timothy Craig1, Peter Styles1 1University of Oxford, Oxford, England, UK. 16:48 491.Biochemical and Histological Correlates of Elevated Lipid Signals after Stroke in Rats Charles Gasparovic1, Gary A. Rosenberg1, James A. Wallace1, Eduard Y. Estrada1, Kristianna Roberts1, Glenn D. Graham1 1University of New Mexico School of Medicine (UNMSOM), Albuquerque, NM, USA. 17:00 492.Relationship between Glucose / Glycogen Metabolism and CBF during Insulin-Induced Hypoglycemia In Vivo In-Young Choi1, Sang-Pil Lee1, Seong-Gi Kim1, Rolf Gruetter1 1University of Minnesota, Minneapolis, MN, USA. 17:12 493.Glial Uptake of Selectively 13C-Enriched Neurotransmitter Glutamate Observed In Vivo Through 13C-15N Coupling Keiko Kanamori1, B.D. Ross1 1Huntington Medical Research Institutes, Pasadena, CA, USA. 17:24 494.A Robust Approach for Spatial Mapping of CMRO2 in Rat Brain Using 17O MRS Imaging Within Two Minutes Xiao-Hong Zhu1, Runxia Tain1, Jae-Hwan Kwag1, Xiaoliang Zhang1, Hellmut Merkle1, John Paul Strupp1, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA. 17:36 495.31P and 1H MRS of Brain and Muscle in Guanidino Acetate Methyltransferase Deficient Mice W.K.J. Renema1, A. Schmidt2, D. Isbrandt2, K. Ulrich3, B. Wieringa1, A. Heerschap1 1University Medical Center Nijmegen, Nijmegen, Netherlands; 2University of Hamburg, Centre for Molecular Neurobiology, Hamburg, Germany; 3University of Hamburg, Pediatric Hospital, Hamburg, Germany. 17:48 496.Direct Detection of Neural Activity in the Rat Brain with 23Na NMR Itamar Ronen1, Kamil Ugurbil1, Seong-Gi Kim1 1University of Minnesota, Minneapolis, MN, USA. STUDY GROUPMR Flow and Motion Quantitation Hall 5 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 STUDY GROUPMR in Drug Research Alsh 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 STUDY GROUPInterventional MR Hall 1 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 STUDY GROUPHyperpolarized Noble Gas MR Forth 19:30 – 21:30 Study Group program detail available at http://www.ismrm.org/01 MORNING CATEGORICAL COURSEEmerging Body MRI Applications Hall 1 07:00 - 08:00 Chairs: Neil M. Rofsky David J. Lomas Educational ObjectivesUpon completion of this course, participants should be able to Recognize the relevance of recent MRI technology developments to diagnostic imaging of the chest, abdomen, and pelvis. Identify the role of fast imaging sequences in body MRI techniques. Describe new imaging applications for evaluating abnormalities of the abdominal and pelvic organs. Implement new protocols for functional imaging of the lung, pancreas, kidney, prostate, and pelvic floor. Recognize the potential value of new methods for interpreting body MRI data. The final five minutes of each talk will be reserved for questions. 07:00 Pelvic Floor ImagingRachel Phillips 07:30 Fetal ImagingDeborah Levine MORNING CATEGORICAL COURSEHigh Field Imaging, Spectroscopy, and fMRI Hall 2 07:00 - 08:00Chairs: Arend Heerschap J. Thomas Vaughan Kamil Ugurbil Educational ObjectivesUpon completion of this course, participants should be able to List and explain the advantages of imaging, spectroscopy and fMRI at field strengths of 3T and higher compared to 1.5T and lower. Describe the basic components of a high-field system for clinical imaging and research. Imaging: List clinical imaging methods, applications and research directions enhanced by high-field MRI. Spectroscopy: Appraise spectroscopy as a diagnostic tool at 3T; review research progress at fields to 7T. fMRI: Evaluate the clinical potential of fMRI at 3T and research applications to 7T; explain fMRI contrast mechanisms and their dependency on field strength. Recognize the role(s) of high-field fMRI in the clinic or laboratory. The final 7 minutes of each talk will be reserved for questions. 07:00 Close-In fMRIGary H. Glover 07:30 Far-Out fMRIKamil Ugurbil MORNING CATEGORICAL COURSEfMRI: What Can We Measure? Hall 5 07:00 - 08:00Chairs: Linda Chang Peter Jezzard Denis Le Bihan Eric C. Wong Educational ObjectivesUpon completion of this course, participants should be able to Describe the current theoretical models for the hemodynamic response to brain activation. Identify those physiological parameters which are accessible to MR measurement. Explain the optimum experimental methods for accessing these parameters. Describe emerging areas of functional MRI methodology. 07:00 Quantitative Measurement of CMRO2 ChangesTimothy L. Davis 07:15 Measurement of Oxygen Extraction Fraction Using T2 ChangesPeter van Zijl 07:30 Spectroscopic Measurement of Glucose Consumption Using 13C NMRFahmeed Hyder 07:45 Discussion MORNING CATEGORICAL COURSEImaging in Sports Medicine Lomond 07:00 - 08:00Chairs: Garry E. Gold Juerg Hodler Educational ObjectivesUpon completion of this course, participants should be able to Use MRI findings to identify mechanisms of joint injury and improve their diagnosis of sports-related abnormalities. Tailor MRI protocols to address sports-related musculoskeletal injuries. Explain the role of MR arthrography in the evaluation of intro-articular injuries. Assess the clinical relevance of sports injuries and correlate MRI findings with surgical treatments. Distinguish trauma-related bone and muscle injuries from neoplastic lesions. 07:00 MRI of Shoulder InstabilityLynne S. Steinbach 07:25 MRI of Knee InjuriesJohannes Bloem 07:50 Discussion MORNING CATEGORICAL COURSEImage Reconstruction Forth 07:00 - 08:00Chair: Michael H. Buonocore Educational ObjectivesUpon completion of this course, participants should be able to Describe gridding theory and compare different gridding techniques. Describe the hardware used in real-time imaging. Explain reconstruction techniques used when the usual amount of data is not available. Describe specialized techniques to correct for system imperfections and to reduce effects of noise. The final five minutes of each talk will be reserved for questions.Reconstruction from Limited Data; Data Sharing 07:00 General Techniques, e.g., View Sharing, UnfoldZhi-Pei Liang 07:30 Techniques for MRACharles Mistretta PLENARY LECTURESMultinuclear MR Clyde Auditorium 08:15 - 09:30Chairs: John R. Griffiths Arend Heerschap Educational Objectives Upon completion of this session, participants should be able to Describe the role of multinuclear MR in understanding, diagnosing, and treating disease. List three diseases on which multinuclear MR is having a major impact. Evaluate the current and future role of high-field multinuclear MRS, especially regarding exceptional data from high fields. Explain the hardware adjustments required for imaging hyperpolarized gases and describe the role of hyperpolarized gases in assessing pulmonary disease processes. 8:15 497.High Field Multinuclear MRS: The Challenge is Paying Off Michael Garwood University of Minnesota, Minneapolis, MN, USA. 8:40 498.Multinuclear Studies on Metabolism in Disease Douglas L. Rothman Yale University School of Medicine, New Haven, CT, USA. 9:05 499.Hyperpolarized Gas Methods in the Clinic Hans-Ulrich Kauczor Universitaet Mainz, Mainz, Germany. Diffusion Analysis Methods Clyde Auditorium 10:30 - 12:30Chairs: Carlo Pierpaoli Stefan T. Skare 10:30 500.White Matter Fiber Tracking Using the Eigenvalue Weighted Average Eigenvector Tie-Qiang Li1, Stefan Skare2, Jonathan Cohen1 1Princeton University, Princeton, NJ, USA; 2Karolinska Institute, Stockholm, Sweden. 10:42 501.Validation of DT-MRI Tractography in the Descending Motor Pathways of Human Subjects. Carlo Pierpaoli1, Alan S. Barnett1, Sinisa Pajevic1, Anette Virta1, Peter J. Basser1 1National Institutes of Health, Bethesda, MD, USA. 10:54 502.Measuring Cortico-Cortical Connectivity Matrices with Diffusion Spectrum Imaging David S. Tuch1, Mette R Wiegell1, Timothy G. Reese1, John W. Belliveau1, Van J. Wedeen1 1Massachusetts General Hospital, Charlestown, MA, USA. 11:06 503.Diffusion Tensor Imaging of the Fast and Slow Diffusion Coefficient Components in Human Brain Stephan Maier1, Sridhar Vajapeyam2, Hatsuho Mamata3, Carl-Fredrik Westin4, Ferenc Jolesz1, Robert Mulkern2 1Harvard University, Brigham and Women's Hospital, Boston, MA, USA; 2Harvard University, Children's Hospital, Boston, MA, USA; 3Harvard University, Brookline, MA, USA; 4Radiology, Boston, MA, USA. 11:18 504.Diffusion Spectrum Imaging Of Fiber White Matter Degeneration Mette R Wiegell1, Timothy Reese1, David S Tuch1, A.Gregory Sorensen1, Van J Wedeen1 1Massachusetts General Charlestown, MA, USA. 11:30 505.Elucidating Neural Structure in Diffusion Tensor MRI Volumes using Streamtubes and Streamsurfaces Song Zhang1, David Laidlaw1 1Brown University, Providence, RI, USA. 11:42 506.Error Analysis of White Matter Tracking Algorithms (Streamlines and Tensorlines) for DT-MRI Mariana Lazar1, Andrew Alexander1 1University of Utah, Salt Lake City, UT, USA. 11:54 507.Diffusion Tensor Imaging and Fiber Tracking of Brain Tumors Susumu Mori1, Michael A. Kraut1, Peter C. Van Zijl1, Meiyappan Solaiyappan1, Henry Brem1, Martin Pomper1 1Johns Hopkins University, Baltimore, MD, USA. 12:06 508.Correction of Eddy-Current Induced Image Warping in Diffusion-Weighted Single-Shot EPI using Constrained Non-Rigid Mutual Information Image Registration R. Bammer1, and M. Auer1 1University of Graz, Graz, Austria. 12:18 509.Early Detection of the Pathologies in Experimental Allergic Neuritis Using High b Value q-Space Diffusion MRS Yaniv Assaf1, Michal Kafri1, Hadassah Shinar1, Joab Chapman1, Amos D. Korczyn1, Gil Navon1, Yoram Cohen1 1Tel Aviv University, Tel Aviv, Israel. Myocardial Perfusion and Coronary MR Angiography Lomond 10:30 - 12:30Chairs: Michael Jerosch-Herold Pamela K. Woodard 10:30 510.Comparative Diagnostic Accuracy of Stress Myocardial Perfusion MRI and SPECT in Detecting Coronary Artery Disease: Receiver Operating Characteristic Analysis in Patients without Myocardial Infarction Nanaka Kawada1, Hajime Sakuma1, Yasutaka Ichikawa1, Kan Takeda1, Munenobu Motoyasu1, Takeshi Nakano1, Atsushi Nozaki2 1Mie University School of Medicine, Tsu, Mie, Japan; 2GE Yokogawa Medical Systems, Hino, Tokyo, Japan. 10:42 511.Does Myocardial Perfusion Reserve (MPR) Represent Ischemia Extent/Severity Dependent Microvascular Integrity?: First-pass MRI Investigation Kyung Il Chung1, Tae-Sub Chung2, Richard D White1, Arthur E Stillman1, Hanns-J Weinmann3, Tae-Hwan Lim4, Jung-Ho Suh5 1Cleveland Clinic Foundation, Cleveland, OH, USA; 2Yonsei University Severance Hospital, Korea; 3Schering AG, Berlin, Germany; 4University of Ulsan, AMC, Korea; 5Ajou University Hospital, Korea. 10:54 512.EVP 1001-1 Allows for a New Paradigm in Cardiac MR Perfusion Imaging Pottumarthi Prasad1, Peter Danias2, Pippa Storey1, Mark Post2, Wei Li1, Peter Seoane3, Phillip Harnish3, Robert Edelman1 1Evanston Northwestern Healthcare, Northwestern University Medical School, Evanston, IL, USA; 2Beth Israel Deaconness Medical Center, Harvard Medical School, Boston, MA, USA; 3Eagle Vision Pharmaceutical Corp., Chester Springs, PA, USA. 11:06 513.Assessment of Regional Differences in Myocardial Blood Flow using MR True-FISP BOLD Imaging Kara B. Wright1, Francis J. Klocke1, Debiao Li1 1Northwestern University, School of Medicine, Chicago, IL, USA. 11:18 514.MR Angiography of the Coronary Arteries Using Magnetization-Prepared Contrast-Enhanced Breath-Hold Volume-Targeted Imaging (MPCE-VCATS) - Initial Clinical Experience James Carr1, Richard Martin McCarthy1, Vibhas Deshpande1, Stephen Shea1, John Paul Finn1, Debiao Li1 1Northwestern University Medical School, Chicago, IL, USA. 11:30 515.Free-Breathing Balanced FFE Coronary Magnetic Resonance Angiography Matthias Stuber1, Peter Börnert2, René M. Botnar1, Elmar Spuentrup3, Kraig V. Kissinger3, Warren J. Manning3 1Beth Israel Deaconess Medical Center, Philips Medical Systems, Boston, MA, USA; 2Philips Research Laboratories, Hamburg, Germany; 3Beth Israel Deaconess Medical Center, Boston, MA, USA. 11:42 516.Noninvasive Measurement of Coronary Vasodilation Michael V. McConnell1, Brian G. Keeffe1, Eric J. Putz1, Craig H. Meyer1, Dwight G. Nishimura1 1Stanford University, Stanford, CA, USA. 11:54 517.Coronary MR Imaging Using Laser-Polarized Helium3 Microbubbles: Preliminary Results in Isolated Pig Heart Virginie Callot1, E. Canet2, J. Brochot3, H. Humblot4, André Briguet1, H. Tournier3, Yannick Crémillieux1 1Université Claude Bernard Lyon, Villeurbanne, France; 2Hopital Cardio-Vasculaire Louis Pradel, Creatis, Lyon, France; 3Bracco Research, Geneva, Switzerland; 4Instiut Laüe-Langevin, Grenoble, France. 12:06 518.3D T2-Weighted Imaging of the Coronary Arteries Using the Intravascular Contrast Agent NC100150 Injection: a Patient Study Lars Johansson1, Tomas Bjerner1, Hakan Ahlstrom1 1Uppsala University Hospital, Uppsala, Sweden. 12:18 519.B-22956, a New Intravascular Contrast Agent for MR Coronary Angiography Friedrich Michael Cavagna1, Pier Lucio Anelli1, Vito Lorusso1, Fabio Maggioni1, Jie Zheng2, Debiao Li3, Dana R. Abendschein2, Paul J. Finn3 1Bracco S.p.A., Milano, Italy; 2Washington University, St. Louis, MO, USA; 3Northwestern University, Chicago, IL, USA. CLINICAL CATEGORICAL COURSEBreast MR Imaging Hall 2 10:30 - 12:30Chairs: Susan M. Ascher Christiane K. Kuhl Educational ObjectivesAt the conclusion of this course, participants should be able to Define important technical implications for performing breast MRI. Identify appropriate indications for breast MRI and how they compare to other modalities. Explain imaging findings based on the International Working Group on Breast MRI’s lexicon. List specific diagnostic criteria used in breast MRI interpretation. Recognize breast MRI features of benign and malignant breast diseases (to include invasive breast cancer and DCIS). 10:30 IntroductionDebra M. Ikeda 10:50 Technical AspectsNola Hylton 11:10 Image Interpretation GuidelinesChristiane K. Kuhl 11:30 Diagnostic Accuracy Compared to Conventional ImagingUwe Fischer 11:50 Established and Evolving ApplicationsMitchell D. Schnall 12:10 MR Guided Interventional TherapySteven E. Harms CLINICAL CATEGORICAL COURSEBrain MR Spectroscopy Hall 5 10:30 - 12:30Chairs: John R. Griffiths Sarah J. Nelson Educational ObjectivesAt the conclusion of this course, participants should be able to Identify situations where MRS may be valuable in the assessment of neurological diseases. Select the most appropriate techniques for such applications. Identify metabolites in spectra from normal and diseased brain tissue. Recognize common spectral artifacts and distinguish them from regions of pathology. 10:30 MRS in Routine Radiology of Brain MassesAntoni Capdevila 11:00 MRSI for Planning Focal Radiation TherapySarah J. Nelson 11:30 Monitoring Pediatric Brain Disorders with MRSArend Heerschap 12:00 MRS of Multiple SclerosisDavid H. Miller Relaxometry and Contrast Mechanisms Hall 1 10:30 - 12:30Chairs: Peter S. Allen Xiaoping P. Hu 10:30 520.Gd Relaxivity Depends on Macromolecular Content Greg J Stanisz1, R Mark Henkelman1 1Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, ON, Canada. 10:42 521.Quantitative T1 Imaging with Inversion Recovery TrueFISP Klaus Scheffler1, Jürgen Hennig1 1Universität Freiburg, Freiburg, Germany. 10:54 522.A Sequence for Rapid Mapping of T2* with Optimised Susceptibility Compensation James Wild1, W.R. Wayne Martin2, Peter Allen2 1Royal Hallamshire Hospital, Sheffield, UK; 2University of Alberta, Edmonton, Alberta, Canada. 11:06 523.Functional Imaging of the Kidneys Using the Inhalation of Pure O2: A Feasibility Study Richard A. Jones1, Mario Ries2, Chrit Moonen2, Nicolas Grenier2 1Université Bordeaux, Bordeaux, France; 2Université Victor Segalen, Bordeaux, France. 11:18 524.Quantitative Imaging of Magnetization Transfer Exchange and Relaxation Properties In Vivo Using MRI John G. Sled1, Bruce Pike1 1McGill University, Montreal Neurological Institute, Montreal, PQ Canada. 11:30 525.Relaxation Behavior of Intermolecular Longitudinal Spin Orders Zhong Chen1, Zhiwei Chen2, Edmund Kwok1, Jianhui Zhong1 1University of Rochester, School of Medicine, Rochester, NY, USA; 2Xiamen University, Fujian, P.R.China. 11:42 526.Physical Origins of Contrast in Intermolecular Multiple-Quantum Coherence Imaging Louis-Serge Bouchard1, Tie-Qiang Li1, Rahim Rizi2, Warren S. Warren1 1Princeton University, Princeton, NJ, USA; 2University of Pennsylvania, Philadelphia, PA, USA. 11:54 527.Pulsed Z-spectroscopic Imaging for Human MRI: Theory and Experimental Technique Vasily L. Yarnykh1 1Moscow State University, Moscow, Russia. 12:06 528.Dipolar Contrast Imaging Applied to In Vivo Musculoskeletal Imaging Denis Grenier1, Lydia K. Wachsmuth2, Lucas Carjaval1, Sharmila Majumdar1 1University of California San Francisco, San Francisco, CA, USA; 2Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. 12:18 529.Deuterium Quenching of 1H2O Relaxation in the Living Rat Brain Jing-Huei Lee1, D. C. Medina1, Xin LI2, F. W. Telang1, P. L. Micca1, J. A. Coderre1, Charles Springer1 1Brookhaven National Laboratory, Upton, NY, USA; 2State University of New York at Stony Brook, Brookhaven National Lab, Upton, NY, USA. fMRI: Clinical Aspects Forth 10:30 - 12:30Chairs: Joachim Roether Christoph M. Segebarth 10:30 530.fMRI Studies of Visceral and Cutaneous Pain in IBS Patients and Normal Subjects Nathan C. Himes1, Richard W. Briggs1, Kaundinya S. Gopinath1, Michael E. Robinson1, Donald D. Price1, G. Nicholas Verne1 1University of Florida, Gainesville, FL, USA. 10:42 531.Identifying which Brain Areas Activated by Painful Stimulation are Specifically Modulated by Drugs Richard Wise1, Richard Rogers1, Stuart Clare1, Susy Bantick1, Alex Ploghaus1, Steve Smith1, Pauline Williams2, Garth Rapeport2, Irene Tracey1 1University of Oxford, John Radcliffe Hospital, Oxford, UK; 2GlaxoWellcome Research and Development, Stevenage, UK. 10:54 532.Temporal Dynamics of Cerebral Processing of Heat Pain - a fMRI Study Peter Erhard1, Michael Valet1, Frode Willoch1, Florian Weilke1, Arthur Schikowski1, Markus Schwaiger1, Bastian Conrad1, Thomas R. Tölle1 1Technische Universität, München, Germany. 11:06 533.Preliminary Study of Vasoactive Hormone Insulin Effect on fMRI BOLD Response in Human Visual Cortex Jae-Hwan Kwag1, Elizabeth Seaquist1, Xiao-Hong Zhu1, Shalom Michaeli2, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA; 2University of New Mexico, Woodridge, IL, USA. 11:18 534.Direct Electrical Stimulation of the Auditory System in Deaf Subjects: An fMRI Study Adnan Z. Alwatban1, Catherine N. Ludman2, Steve M. Mason2, Gerard M. O'Donoghue2, Andrew M. Peters1, Peter G. Morris1 1University of Nottingham, Nottingham, UK; 2Queen's Medical Centre, Nottingham, UK. 11:30 535.Wada-Validated Clinical fMRI Reveals Typical and Atypical Speech Activation Patterns in Individual Patients with Epilepsy Michael Okujava1, Hennric Jokeit2, Friedrich G. Woermann2 1currently: Bethel Epilepsy Center, Germany, Center for Experimental Neurology, Tbilisi, Georgia; 2Bethel Epilepsy Center, Mara Hospital, Bielefeld, Germany. 11:42 536.Cerebral Activation During Vagal Nerve Stimulation: A Functional MR Imaging Study in Seizure Patients Christopher G. Filippi1, Richard Watts1, P. Mark Li1 1Weill Medical College, Cornell University, New York, NY, USA. 11:54 537."Visual" and "Auditory" Cortical Activation by Acupuncture Has No Specific Cortical-Acupoint Correlation - A fMRI Study of Electroacupuncture with Control Stimulation Ming-Ting Wu1, Jer-Ming Sheen2, Kai-Hsiung Chuang3, Chin-Ying Tsai1, Shieuh-Lii Chin1, Ping-Hong Lai1, Huay-Ben Pan1, Chien-Fang Yang1 1Kaohsiung Veterans General Hospital, School of Medicine, National Yang Ming University, Taiwan; 2Chang-Chung Memorial Hospital-Kaohsiung Medical Center; 3National Taiwan University, Taiwan. 12:06 538.Evidence of Chronic Tolerance to Nicotine as Measured with fMRI Thomas J Ross1, Stephen A Williams2, Robert C Risinger1, Betty Jo Salmeron1, Alan S Bloom1, Elliot Stein1 1Medical College of Wisconsin, Milwaukee, WI, USA; 2Pfizer, Inc, Groton, CT, USA. 12:18 539.The Functional Connectivity During Deep Brain Stimulation: A Pilot fMRI Study Jaroslav Tintera1, Robert Jech2, Dusan Urgosik3 1IKEM, Prague, Czech Republic; 2Charles University, Prague, Czech Republic; 3Nemocnice Na Homolce, Prague, Czech Republic. Vascular Intervention and Device Tracking Alsh 10:30 - 12:30Chairs: Thomas Kahn Michael Wendt 10:30 540.Toward Comprehensive Performance of MR-Guided Vascular Interventions: Combined Dynamic Imaging of the Coronary Arteries and Assessment of Myocardial Perfusion Nikolaos V. Tsekos1, Pamela Woodard1, Glenn Foster1, Terry Sharp1, Robert J. Gropler1 1Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO. USA. 10:42 541.Coronary Artery Intervention Guided with Magnetic Resonance Imaging Jean-Michel Serfaty1, Xiaoming Yang1, Ananda Kumar1, Ergin Atalar1 1Johns Hopkins University, Baltimore, MD, USA. 10:54 542.A Combined Electrophysiology/MR Antenna Catheter Robert C Susil1, Christopher J Yeung1, Albert C Lardo1, Ergin Atalar1 1Johns Hopkins University, Baltimore, MD, USA. 11:06 543.Intravascular MR Imaging of Vascular Gene Delivery: A Feasibility Study Xiaoming Yang1, Ergin Atalar1, Dechun Li1, Jean-Michel Serfaty1, Danming Wang1, Linzhao Cheng1 1Johns Hopkins Unversity, Baltimore, MD, USA. 11:18 544.MR-Controlled Fast Optical Switching of a Resonant Circuit Mounted to the Tip of a Clinical Catheter Steffen Weiss1, Holger Eggers1, Tobias Schaeffter1 1Philips Research Hamburg, Hamburg, Germany. 11:30 545.A Fast 3D Tracking System Using Tuned Fiducial Markers and Limited Projection Reconstruction Chris Flask1, Kent Lee1, Ajit Shankaranarayanan1, Eddy Wong1, Daniel Elgort1, Jeffrey L. Duerk1, Jonathan Lewin1, Michael Wendt2 1Case Western Reserve University / University Hospitals of Cleveland, Cleveland, OH, USA; 2Siemens Medical Systems, Iselin, NJ, USA. 11:42 546.Instrument Localization in MRI Using Electron Spin Resonance Mika Ylihautala1, Gösta Ehnholm1, Erkki Vahala1, Lasse Jyrkinen2, Osmo Tervonen3 1Marconi Medical Systems Finland, Inc., Vantaa, Finland; 2University of Oulu, Oulu, Finland; 3Oulu University Hospital, Oulu, Finland. 11:54 547.A Truly Hybrid X-Ray/MR System for Guidance of Minimally Invasive Procedures: In Vivo Validation Rebecca Fahrig1, Kim Butts1, Z. Wen1, R. Saunders2, S. Kee1, Norbert J. Pelc1 1Stanford University, Stanford, CA USA; 2GE Medical Systems, Milwaukee, WI, USA. 12:06 548.Optical Tracking of Surface Coils for Image-Guided Interventional Procedures C. A. White1, M. J. Bronskill1, Gal Sela1, Walter Kucharczyk1 1University of Toronto, Toronto, ON, Canada. 12:18 549.A Flexible Instrument Tracking System for Intra-Operative MRI Gal Sela1, Michael Bronskill1, Walter Kucharczyk2 1Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, ON, Canada; 3University of Toronto, Faculty of Medicine, Toronto, ON, Canada. GOLD CORPORATE MEMBER LUNCHTIME SYMPOSIUM GE Medical Systems Argyll (Moat House) 12:30 – 13:30 BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Rapid Imaging Clyde Auditorium Thursday: 13:30 - 15:30 Chairs: Stephen J. Riederer John P. Mugler Jürgen Hennig Please see page 239 for details. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Intraoperative and Miscellaneous Interventional MRI Forth Thursday: 13:30 - 15:30 Chairs: Charles L. Truwit Jens-Peter Schneider Please see page 273 for details. CLINICAL SCIENCE FOCUS SESSIONMRS in Neurologic and Psychiatric Diseases Lomond 13:30 - 15:30Chairs: Jullie W. Pan Dieter J. Meyerhoff 13:30 550.Alterations on Mitochondrial Functionality in Migraine Studied by Functional 1HMRS R. Tarducci1, O. Presciutti1, P. Sarchielli2, A. Alberti2, V. Gallai2, G. Gobbi1 1Azienda Ospedaliera di Perugia, Perugia, Italy; 2Università di Perugia, Perugia, Italy. 13:40 551.Effect of Tamoxifen on Brain Chemistry Thomas Ernst1, Linda Chang1, Kyle Boone1, Dilrukshie Cooray1, Corazon Salvador1, Rowan Chlebowski1 1Brookhaven National Laboratory, Upton, NY, USA. 13:50 552.A Comparison of Single Voxel Proton MR Spectroscopy and Spectroscopic Imaging in Subjects with HIV-Associated Cognitive Impairment: Results of a Multi-Center Trial Peter B. Barker1, Martin Pomper1, Linda Bobo1, Thomas Ernst2, K. Zhong2, L. Chang2, Dikoma C. Shungu3, Xiangling Mao3, K. Marder3, D. Shibata4, G. Schifitto4, Ned C. Sacktor1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2Brookhaven National Laboratory, Upton, NY, USA; 3Columbia University, New York, NY, USA; 4Rochester University, Rochester, NY USA. 14:00 553.Evaluation and Prognosis of Severe Traumatic Brain Injury Using Single and Multi-Voxel Proton MR Spectroscopy. Karen Angela Tong1, Barbara Ann Holshouser1, Austin Colohan1, Lori Shutter1 1Loma Linda University, Loma Linda University Medical Center, Loma Linda, California USA. 14:10 554.1H-MR-spectroscopy and Apparent Diffusion Coefficients of the Hippocampus in Patients with Temporal Lobe Epilepsy Jörn Kaufmann1, Emrah Düzel1, Sebastian Guderian1, Jens-Max Hopf1, Nils Bodammer1, Martin Kanowski1, Claus Tempelmann1, Hans-Jochen Heinze1 1O.v.G. University, Magdeburg, Germany. 14:20 555.Frontal Lobe NAA Reductions in Temporal Lobe Epilepsy by 1H MRSI Joyce Suhy1, Kenneth D. Laxer1, Derek Lee Flenniken1, Jana Axelrad1, Aristides Andres Capizzano1, Michael W Weiner1 1University of California, San Francisco, San Francisco, CA, USA. 14:30 556.Brain Myo-Inositol Decreases, NAA is Unchanged in Healthy Volunteers in Response to Lithium Administration Blaise deB. Frederick1, Aimee M. Parow1, Christina M. Demopulos2, Gary S. Sachs2, Caroline Dufault2, Constance M. Moore1, Perry F. Renshaw1 1McLean Hospital Brain Imaging Center, Harvard Medical School, Belmont, MA, USA; 2Massachusetts General Hospital Bipolar Program, Harvard Medical School, Boston, MA, USA. 14:40 557.Different Relationships among Cortical Amino Acids in Unipolar and Bipolar Depression Graeme F. Mason1, Amit Anand1, Gerard Sanacora1, Neill Epperson1, Kristin Haga1, Michael Appel1, Andrew W. Goddard1, Dennis S. Charney2, Douglas L. Rothman1, John H. Krystal1 1Yale School of Medicine, New Haven, CT, USA; 2National Institute of Mental Health, USA. 14:50 558.Electroconvulsive Therapy Induces Metabolic Changes in Severe Depressed Patients in the Anterior Cingulum Bettina Pfleiderer1, Nikolaus Michael1, Andreas Erfurth1, Patricia Ohrmann1, Matthias Wolgast1, Volker Arolt1, Walter Heindel1 1University of Münster, Münster, Germany. 15:00 559.Brain Dysfunction in Alcohol Dependence: Neuropsychological and In Vivo Proton MRS Study Mahesh Kumar1, Atul Ambekar1, N. G. Desai1, H.P. Jhingen1, S. Gupta1, N. R. Jagannathan1 1All India Institute of Medical Sciences, New Dehli, India. 15:10 560.Region-Specific Changes in Phospholipid Metabolism in Schizophrenia: A 31P Chemical-Shift Imaging Study at 4.0 Tesla J. Eric Jensen1, Yousef M. Al-Semaan2, Dick J. Drost1, Peter C. Williamson2, Richard W.J. Neufeld3, Ravi S. Menon4 1University of Western Ontario, St. Joseph's Health Centre, London, Ontario, Canada; 2London Health Science Centre, London, Ontario, Canada; 3University of Western Ontario, London, Ontario, Canada; 4The John P. Robarts Research Institute, London, ON, Canada. 15:20 561.31P NMR Detects Abnormal Phospholipid Composition in Postmortem Schizophrenic Brain Richard A. Komoroski1, John M. Pearce1, Masao Omori2, W. Sue Griffin1, Robert E. Mrak1, Craig N. Karson3 1University of Arkansas for Medical Sciences (UAMS), Little Rock, AR USA; 2Fukui Medical School, Matsuoka, Fukui Japan; 3Central Arkansas Veterans Healthcare System, Little Rock, AR, USA. CLINICAL SCIENCE FOCUS SESSIONBreast MR Imaging Hall 2 13:30 - 15:30Chairs: Lindsay W. Turnbull Hadassa Degani 13:30 562.Optimising Flip-Angles for Improved T1 Calculation in 3D Contrast-Enhanced Breast MR Imaging Paul Armitage1, Chris Behrenbruch1, Michael Brady1, Niall R. Moore1 1University of Oxford, Oxford, UK. 13:40 563.Diagnosis of Benign and Malignant Breast Lesions using Multiparametric MRI Michael Jacobs1, David A. Bluemke1, Zaver Bhujwalla1, Cindy Maranto1, Peter B. Barker1 1Johns Hopkins University, Baltimore, MD, USA. 13:50 564.Simultaneous Dynamic and Architectural MR Breast Imaging Lawrence Dougherty1, Hee Kwon Song1, Mitchell D. Schnall1 1University of Pennsylvania Medical Center, Philadelphia, PA, USA. 14:00 565.Concentric Regional Sampling in Contrast Enhanced Imaging of the Breast Peter Gibbs1, Lindsay W Turnbull1 1Hull Royal Infirmary, Hull, England, UK. 14:10 566.A Two Center Clinical Testing of the 3TP Method for Contrast Enhanced Breast MRI. Edna Furman-Haran1, Hadassa Degani1, Kevin Kirshenbaum2, Frederick Kelcz3 1Weizmann Institute of Science, Rehovot, Israel; 2Illinois Masonic Medical Center, Chicago, IL, USA; 3University of Wisconsin Hospital, Madison, WI, USA. 14:20 567.Measurements of Regional Blood Flow and Blood Volume in Breast Cancer With MRI Jean-Paul Delille1, Priscilla J Slanetz2, Eren D Yeh2, Daniel B Kopans2, Leoncio Garrido1 1Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; 2Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 14:30 568.Assessment of Angiogenesis in Breast Lesions Using Dynamic Contrast Enhanced MR Mammography and Immunohistochemical Biomarkers M. Y. Su1, Y. L. Wan2, Y. C. Cheung2, J. P. Fruehauf3, H. Yu1, A. Kyshtoobayeva3, S. Hsueh2, S. S. Chen2, O. Nalcioglu1 1University of California, Irvine, CA, USA; 2Chang Gung Memorial Hospital, Linkou, Taiwan; 3Oncotech Inc., Irvine, CA, USA. 14:40 569.Lymph Node Staging with a Lymph Node-Specific Contrast Agent (Sinerem®, Guerbet) in Patients with Breast Cancer Sven Claude André Michel1, Borut Marincek1, Johannes Fröhlich2, Daniel Nanz1, Daniel Fink1, Rosmarie Caduff1, Rahel Kubik-Huch1 1University Hospital, Zurich, Switzerland; 2Guerbet-Group, Zurich, Switzerland. 14:50 570.In Vivo Turbo Spin Echo Intensities Correlate with Oestrogen Receptor Status in Breast Tumors. Patrick J Gilligan1, Orla Mc Cormack2, Fidelma L Flanagan1, Diane Bergin1, Michael J Kerin2, Thomas F Gorey2, Joseph T Ennis3 1Institute of Radiological Sciences, Dublin, Ireland; 2Mater Hospital, Dublin, Ireland; 3Institute of Radiological Sciences, University College Dublin, Dublin, Ireland. 15:00 571.Evaluation of Hormone Replacement Therapy by MRI Adrian Knowles1, Clare Kearney2, David Purdie2, Peter Gibbs2, Lindsay W Turnbull2 1Philips Medical Systems, Best, The Netherlands; 2Hull Royal Infirmary, Hull, UK. 15:10 572.Non-Ridig Registration of Contrast-Enhanced MRI to Quantify Chemotherapy Response in Breast Cancer for Histological Comparison Christian Behrenbruch1, Paul Armitage1, Michael Brady1, Niall R. Moore1, Charles Hardingham1 1University of Oxford, Oxford, England, UK. 15:20 573.Assessment of Soya Bean Oil Breast Implants by MRI Jane Hawnaur1, Mary Wilson2, Edwin Elangovan2, Nigel Bundred2 1University of Manchester, Manchester, England, UK; 2South Manchester University Hospitals Trust, Manchester, England, UK. CLINICAL SCIENCE FOCUS SESSIONPediatric MR Spectroscopy Hall 5 13:30 - 15:30Chairs: Albert Thomas Brian David Ross 13:30 574.Ureidopropionase Deficiency: A Novel Inborn Error of Metabolism Discovered Using Body Fluid NMR Spectroscopy S. Moolenaar1, U. Engelke1, G. Göhlich-Ratmann2, B. Assmann3, C. Bräutigam3, A. van Kuilenburg4, A. van Gennip4, J. de Jong1, T. Voit2, G. Hoffmann3, P. Vreken4, R. Wevers1 1University Medical Centre, Nijmegen, The Netherlands; 2University Hospital, Essen, Germany; 3University Hospital, Heidelberg, Germany; 4Academic Medical Centre, Amsterdam, The Netherlands. 13:40 575.In vivo NAA Synthesis Rate in Canavan´s Disease Patients using 13C MRS Angel Moreno-Torres1, Stefan Bluml1, Brian Ross2 1Rudi Schulte Research Institute, Santa Barbara, CA, USA; 2Huntington Medical Research Institutes, Pasadena, CA, USA. 13:50 576.Brain Glycogen Detection in Pompe's Disease Adrianus Van Den Bergh1, Dennis Klomp1, Jan Smeitink1, Ron Wevers1, Arend Heerschap1 1University Hospital Nijmegen, Nijmegen, Netherlands. 14:00 577.Brain Neurochemical Abnormalities in Childhood Autism S. D. Friedman1, D.W.W. Shaw1, A. A. Artru1, D. Echelard1, T. L. Richards1, S. Posse2, G. Dawson1, S. R. Dager1 1University of Washington, Seattle, WA, USA; 2Wayne State University, Detroit, MI, USA. 14:10 578.Comparison of Regional Cerebral Metabolite Profiles in Two Mitochondrial Encephalomyopathies, MELAS and MERRF, using 1H MRSI D.C. Shungu1, M. Sano1, W.S. Millar1, P. Kaufmann1, X. Mao1, A. Kwan1, S. DiMauro1, D.C. De Vivo1 1College of Physicians and Surgeons, Columbia University, New York, NY, USA. 14:20 579.A Comparison of Proton MR Spectroscopic and Diffusion Tensor Brain MR Imaging in X-linked Adrenoleukodystrophy Florian Eichler1, R. Itoh1, Peter B. Barker1, Elias Melhem2, Susumu Mori1, Peter C. Van Zijl1, Hugo W. Moser1, Gerald V. Raymond1 1Johns Hopkins University, Baltimore, MD, USA; 2Johns Hopkins University, Timonium, MD, USA. 14:30 580.Predicting Clinical Outcome in Perinatal Asphyxia by MRI and MRS Maria Zarifi1, Loukas Astrakas2, David Zurakowski2, Tina Poussaint2, Andre du Plessis2, Aria Tzika2 1Agia Sofia Children's Hospital, Athens, Atiiki, Greece; 2Children's Hospital, Harvard Medical School, Boston, MA, USA. 14:40 581.Proton Spectroscopic Metabolite Signal Relaxation Times in Preterm Infants - a Prerequisite for Quantitative Spectroscopy in Infant Brain Harald Kugel1, Bernhard Roth1, Oliver Schulte1, Frank Pillekamp1, Gabriele Benz-Bohm1, Klaus Lackner1 1University of Cologne, Köln, Germany. 14:50 582.In Vivo Magnetic Resonance Spectroscopy in a Patient with Creatine Deficiency Syndrome: New Aspects on Mechanism of Creatine Uptake in Brain and Muscle Thorsten Thiel1, Regina Ensenauer2, Jürgen Hennig1, Willy Lehnert2 1University Hospital Freiburg, Freiburg, Germany; 2University Children's Hospital, Freiburg, Germany; 15:00 583.Quantitative Analysis of Brain Metabolites in 13 Patients with Sjögren-Larsson Syndrome Marinette van der Graaf1, M.A.A.P. Willemsen1, J. J. Rotteveel1, Arend Heerschap1 1University Medical Center Nijmegen, Nijmegen, Netherlands. 15:10 584.MRS in Homocystinuria: Severely Reduced mI in Neurologically Normal MTHFR Deficient Patients Else Rubæk Danielsen1, Flemming Skovby1, Carsten Thomsen1 1Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 15:20 585.MR Spectroscopic Changes in Pediatric Acute Hydrocephalus, Sub-Acute Hydrocephalus and Cortical Atrophy Miriam Scadeng1, Rex Moats1, S Yamada1, Marvin D Nelson Jr1, J Gordon McComb1 1Children’s Hospital Los Angeles, Los Angeles, CA, USA. CLINICAL SCIENCE FOCUS SESSIONMR Imaging of Female Pelvis Hall 1 13:30 - 15:30Chairs: Susan M. Ascher Jane M. Hawnaur 13:30 586.Dynamic MRI of the Pelvic Floor in Stress Urinary Incontinence: Technique, Normative Data in Continent Women, and Comparison with Physical Examination Alan H. Stolpen1, Marc A. Hodroff1, Melody A. Denson1, Lizann Bolinger1, Bridget Zimmerman1, Bruce P. Brown1, Karl Kreder1 1University of Iowa, Iowa City, IA, USA. 13:40 587.Pelvic Floor Anatomy in Stress Urinary Incontinence: MR Imaging with Endovaginal Coil Jeong Kon Kim1, Kyoung-Sik Cho1, Hong Sik Kim1, Myoung Soo Choo1 1Asan Medical Center, University of Ulsan, Seoul, Korea. 13:50 588.Magnetic Resonance Imaging of the Paravaginal Fascia and Urethra in Women with Urinary Stress Incontinence Nandita Maria de Souza1, O J Daniels1, Andreanna Williams1, David James Larkman1, David John Gilderdale1 1Imperial College School of Medicine, Hammersmith Hospital, London, England, UK. 14:00 589.Reproducibility of Serial MR Measurement of Female Sexual Arousal Response Kenneth R Maravilla1, Yunyu Cao1, Patricia Garland1, Denise Echelard1, Julia R. Heiman1, Laura J. Hart1, Jean Kallhoff1, Barry Peterson2, Robert Weisskoff3 1University of Washington, Seattle, WA, USA; 2Pfizer Pharmaceutical; 3EPIX Medical Inc., Cambridge, MA, USA. 14:10 590.The Application of a Quantitative Magnetisation Transfer Sequence in the Study of Placental Development Damian Tyler1, Rachel Moore1, Stephen Ong1, Philip Baker1, Ian Johnson1, Penny Gowland1 1University of Nottingham, Nottingham, England, UK. 14:20 591.Fetal Volumetry Based on 3D Reconstructions of 2D Single-Shot Fast Spin-Echo MR Data Sets Rahel A Kubik-Huch1, Simon Wildermuth1, Luca Cettuzzi1, Annett Rake1, Burkhardt Seifert1, Rabih Chaoui1, Nino Teodorovic1, Borut Marincek1 1University Hospital Zürich, Zürich, Switzerland. 14:30 592.Intra-voxel Incoherent Motion Measurements of Spiral Artery Function During Normal and Compromised Pregnancy. Rachel Moore1, Stephen Ong1, Damian Tyler1, Philip Baker1, Ian Johnson1, Penny Gowland1 1Nottingham University, Nottingham, UK. 14:40 593.Uterine Fibroid Embolization: Assessment of Treatment Response Using Extraslice Spin Tagging (EST) MRI Klaus D. Hagspiel1, Alan H. Matsumoto1, Stuart Scott Berr1 1University of Virginia, Charlottesville, VA USA. 14:50 594.Application of the VIBE (Volumetric Interpolated Breath-hold Examination) MR Technique to the Evaluation and Follow-up of Patients Undergoing Uterine Fibroid Embolization Naoki Takahashi1, Vamsidhar Narra1, Brooke E Spencer1, David Hovsepian1 1Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, USA. 15:00 595.Improving the Specificity of Diagnosis of Ovarian Cancer Using Dynamic Contrast-Enhanced MRI (DCE-MRI) Glen H Hall1, Stephen L Atkin2, Lindsay W Turnbull2 1University of Hull, Hull Royal Infirmary, Hull, East Yorkshire, UK; 2University of Hull, Hull, East Yorkshire, UK. 15:10 596.Preoperative Staging of Endometrial Carcinoma: Accuracy of T2-Weighted Fast Spin Echo Sequence and Dynamic Gadolinium-Enhanced MR Imaging Riccardo Manfredi1, Paoletta Mirk2, Tommasina Meloni, Rossella Lopez, Alessandro P Margariti, Antonia Testa, Giovanni Scambia, Pasquale Marano 1Rome, Italy; 2"A Gemelli" University Hospital, Rome, Italy. 15:20 597.Evaluation of Fast Real IR Imaging in the Pelvis Yuichi Yamashita1, Satoshi Sugiura2, Takashi Ishimori3, Satoru Nakano3, Yasutane Mori3, Motoomi Ohkawa3 1Toshiba Medical Systems Co.,Ltd., Kagawa Japan; 2Toshiba Corp, Medical R&D Center, Japan; 3Kagawa Medical University, Kagawa, Japan; Image Processing: Cardiac and Vascular Clyde Auditorium 16:00 - 18:00Chairs: Rob J. Van der Geest Thomas K.F. Foo 16:00 598.Real-time Volumetric MR Imaging Michael A. Guttman1, Jonathan Sorger2, Elliot R. McVeigh1 1National Institutes of Health, Bethesda, MD, USA; 2Johns Hopkins University, Baltimore, MD, USA. 16:12 599.A Graphical Approach for the Analysis of Myocardial BOLD effect. Meiyappan Solaiyappan1, Garth M. Beache1, Sandeep N. Gupta2, Paul A. Bottomley1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2GE Medical Systems, Waukesha, WI, USA. 16:24 600.Fully Automated, Time-Continuous Contour Delineation of the Endo- and Epicardium in Short-Axis Cardiac MR Image Sequences B.P.F. Lelieveldt1, R.J. van der Geest1, S.C. Mitchell2, J.G. Bosch1, M. Sonka2, J.H.C. Reiber1 1Leiden University Medical Center, Leiden, the Netherlands; 2The University of Iowa, Iowa City, IA, USA. 16:36 601.Rapid Left Ventricular Border Detection with a Multi-Resolution Graph Searching Approach Daniel R. Thedens1 1University of Iowa, Iowa City, IA, USA. 16:48 602.Automatic Realignment of Serial Myocardial Perfusion Images Alain Lalande1, Mélanie Lourdet1, Paul Michael Walker1, Douraied Ben Salem1, Yves Cottin1, Louis Legrand1, Jean Eric Wolf1, François Brunotte1 1Faculté de Médecine de Dijon, Dijon, France. 17:00 603.Virtual Tagging: A Novel Method for Evaluating Myocardial Function Sharmeen Masood1, G N Estcourt, D N Firmin2, P Gatehouse, S Collins, G Z Yang 1Imperial College of Science, Technology and Medicine, London, UK; 2Imperial College of Science, Technology and Medicine, University of London, Royal Brompton Hospital, London, UK. 17:12 604.Automated Tag Line Tracking In Tagged White Blood Images Thomas S. Denney Jr.1 1Auburn University, Auburn, Al, USA. 17:24 605.Improving HARP to Produce Smooth Strain Maps of the Heart Nael F Osman1, Jerry Ladd Prince1 1Johns Hopkins University, Baltimore, MD, USA. 17:36 606.Active Edge Maps for Registration of Carotid Artery MRI William Kerwin1, Chun Yuan1 1University of Washington, School of Medicine, WA, USA. 17:48 607.An Analysis of Vessel Enhancement Filters Based on the Hessian Matrix for Intracranial MRA Brian E. Chapman1, Dennis Lee Parker2 1University of Pittsburgh, Pittsburgh, PA, USA; 2University of Utah, Salt Lake City, UT, USA. Magnets, Gradients, and Shims Lomond 16:00 - 18:00Chairs: Blaine A. Chronik Lawrence Latour 16:00 608.Elliptical MRI Magnets Stuart Crozier1, Huawei Zhao1, David Doddrell1 1Queensland University, Brisbane, QLD, Australia. 16:12 609.Super-Parallel MR Microscope Katsumi Kose1, Tomoyuki Haishi1, Yoshimasa Matsuda1, Izumi Anno1 1University of Tsukuba, Tsukuba, Japan. 16:24 610.A Prepolarized MRI Scanner Greig Scott1, Blaine Chronik1, Nate Matter1, Hao Xu1, Patrick N. Morgan2, Luchin Wong1, Albert Macovski1, Steven Conolly1 1Stanford University, Stanford, CA, USA; 2Texas A&M University, College Station, TX, USA. 16:36 611.Making MRI Quiet William A. Edelstein1, Robert A. Hedeen1, Richard P. Mallozzi1, Sayed-Amr El-Hamamsy1, Robert A. Ackermann1, David E. Dean2 1GE Corporate R&D, Schenectady, NY, USA; 2GE Medical Systems, Milwaukee, WI, USA. 16:48 612.Magnetic Forces and Torques on Local Gradient Coils: An Example Using a Head Gradient Coil John Schenck1, William Barber1, Mark Albers1, Lawrence Latour2, Lisa Shumaker3, William Edelstein1 1GE Corporate R&D, Schenectady, NY, USA; 2National Institutes of Health, Bethesda, MD, USA; 3IGC Medical Advances, Milwaukee, WI, USA. 17:00 613.Short Local Gradient Coil Design Using Efficiency-Optimized Remote Current Return Paths Hanbing Lu1, Andrzej Jesmanowicz1, S.- J. Li1, James Hyde1 1Medical College of Wisconsin, Milwaukee, WI USA. 17:12 614.A Universal Law for Optimizing Short Magnets and Gradient Coils Beibei Zhang1, Carl Gazdzinski1, Blaine Chronik2, Hao Xu2, Steven Conolly2, Brian K. Rutt1 1The John P. Robarts Research Institute, London, Ontario Canada; 2Stanford University, Stanford, CA, USA. 17:24 615.The Fiber Optic Stethoscope: An MR-Compatible Cardiac Monitoring and Gating System Anja C.S. Brau1, Laurence W. Hedlund1, G. Allan Johnson1 1Duke University Medical Center, Durham, NC, USA. 17:36 616.Calculation of Static Magnetic Field Distortions in a Multi-tissue Human Head Model for MRI Bei Yang, Christopher M. Collins1, Michael B. Smith1 1Penn State College of Medicine, Hershey, PA, USA. 17:48 617.Local Ferroshims Using Office Copier Toner Andrzej Jesmanowicz1, Vinai Roopchansingh1, R. W. Cox1, Piotr Starewicz2, W. F.B. Punchard2, James Hyde1 1Medical College of Wisconsin, Biophysics Research Institute, Milwaukee, WI USA; 4Resonance Research, Inc., Billerica, MA, USA. MR PHYSICS AND TECHNIQUES FOR CLINICIANS Hall 2 16:00 - 18:00Chairs: Frank R. Korosec Joseph C. McGowan Educational ObjectivesAt the conclusion of this course, participants should be able to Define and describe the fundamental principles of MR imaging, including spin magnetization, the Larmor relationship, relaxation phenomena, and the process of using the spin magnetization to produce an image. Explain imaging pulse sequences based upon spin and gradient echoes, including fast spin echo and echo planar techniques. Design MR imaging protocols for diagnostic applications considering image contrast, spatial resolution, acquisition time, signal-to-noise ratio, and artifacts. Describe the principles and capabilities of various advanced MR techniques including perfusion and diffusion, functional, interventional, and cardiac MR imaging. 16:00 Cardiac MRIFrank R. Korosec 16:40 Interventional MRIMark E. Ladd 17:20 Functional MRIM. Elizabeth Meyerand Spectroscopy Localization and Methodology Hall 5 16:00 - 18:00Chairs: Roland Kreis Daniel M. Spielman 16:00 618.Initial Experience with an "Unspoiled" Spin-Echo Sequence for Short TE Proton-MR-Spectroscopy of the Human Brain Stefan Roell1 1Siemens AG, Erlangen, Germany. 16:12 619.Phase Coherent Averaging in Magnetic Resonance Spectroscopy Using Interleaved Reference Scans: Compensation of Motion Artifacts and Magnetic Field Instabilities Thorsten Thiel1, Michael Czisch2, Gregor-K. Elbel2, Jürgen Hennig1 1University Hospital Freiburg, Freiburg, Germany; 2Max Planck Institute of Psychiatry, München, Germany. 16:24 620.Determination of Glutamate in Human Brain at 3 Tesla using PRESS and a Multiple Quantum Filter Florian Schubert1, Frank Seifert1, Herbert Rinneberg1 1Physikalisch-Technische Bundesanstalt, Berlin, Germany. 16:36 621.A New Filtering Strategy Specific to Strongly-Coupled Spin Systems in Proton NMR Spectroscopy H. Kim1, J. M. Wild1, P. S. Allen1 1University of Alberta, Edmonton, Alberta, Canada. 16:48 622.Dualband Spectral-Spatial Pulses in Prostate MRSI Amir A. Schricker1, John M. Pauly2, John Kurhanewicz1, Mark G. Swanson1, Daniel B. Vigneron1 1University of California, San Francisco, CA, USA; 2Stanford University, Stanford, CA, USA. 17:00 623.Reduction of Truncation Artifact in Spectroscopic Images Using a Dual-Density Spiral k-space Trajectory Shantanu Sarkar1, Keith Heberlein1, Xiaodong Zhang1, Yasser Kadah2, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA; 2Cairo Univeristy, Giza, Egypt. 17:12 624.1H MR Spectroscopic Imaging in Human Muscle: Removal of Extra-Myocellular Lipid Artifacts and Determination of the Spatial Distribution of Intra-Myocellular Lipids Peter Vermathen1, Roland Kreis1, Bruno Jung1, Chris Boesch1 1University & Inselspital, Bern, Switzerland. 17:24 625.Fast Multislice Spectroscopic Imaging using SENSE Ulrike Dydak1, Klaas P. Pruessmann1, Markus Weiger1, Dieter Meier1, Peter Boesiger1 1University and ETH Zurich, Zurich, Switzerland. 17:36 626.Reduced Measurement Time in U-FLARE based Correlation Peak Imaging by Circular Chemical Shift Encoding Dirk Mayer1, Wolfgang Dreher2, Dieter Leibfritz2 1Stanford University, Stanford, CA, USA; 2Universität Bremen, Bremen, Germany. 17:48 627.Feasibility of 13C NMR Spectroscopy of the Human Brain at 7 Tesla using Adiabatic 1H Decoupling Rolf Gruetter1, Gregor Adriany1, Peter Andersen1, Kamil Ugurbil1 1University of Minnesota, Minneapolis, MN, USA. Tumor Perfusion and Oxygenation Hall 1 16:00 - 18:00Chairs: Simon Robinson Orhan Nalcioglu 16:00 628.Factoring the Permeability and Perfusion Contributions to CR Bolus-Tracking Pharmacokinetics Thomas E. Yankeelov1, Charles Springer2 1Brookhaven National Laboratory, SUNY, Stony Brook, NY, USA; 2Brookhaven National Laboratory, Upton, NY, USA. 16:12 629.Perfusion and Permeability: Can Both Parameters Be Evaluated Separately from Dynamic MR Data? Juergen Griebel1, Sascha Pahernik2, Robert Lucht1, Alexander DeVries3, Karl-Hans Englmeier4, Marc Dellian2, Gunnar Brix1 1Federal Office for Radiation Protection, Neuherberg, Germany; 2University of Munich, Munich, Germany; 3University of Innsbruck, Innsbruck, Austria; 4GSF Research Center, Neuherberg, Germany. 16:24 630.Dynamics of Tumor Signal Ehnancement by Polymeric Agents: Difference Between Growing Tumors and Small Dormant Tumors Ed Uzgiris1, Yudong Zhu1 1G. E. Corporate R & D, Niskayuna, NY, USA. 16:36 631.Overexpression Of Dimethylarginine Dimethylaminohydrolase Increases Tumour Blood Volume, Assessed By Susceptibility Contrast Enhanced MRI Vassiliki Kostourou1, Guy S. Whitley1, John R. Griffiths1, Simon Robinson1 1St. George's Hospital Medical School, London, England, UK. 16:48 632.Differentiation of Prostatitis from Prostate Carcinoma Using 1H MR Spectroscopic Imaging and Dynamic Contrast-Enhanced MRI Ferdinand A. Van Dorsten1, Marc Engelbrecht1, Marinette Van Der Graaf1, Jean De La Rosette1, Jelle Barentsz1, Arend Heerschap1 1University Medical Center Nijmegen, Nijmegen, Netherlands. 17:00 633.Effects of Carbogen Breathing on Tissue Oxygenation and Perfusion in Head and Neck Tumors as Measured by MRI M. Rijpkema1, J. Kaanders1, F. Joosten1, A. Van Der Kogel1, A. Heerschap1 1University Medical Center Nijmegen, Nijmegen, Netherlands. 17:12 634.In Vivo BOLD Contrast MRI Mapping of Subcutaneous Vascular Function and Maturation: Validation by Intravital Microscopy Michal Neeman1, Hagit Dafni1, Omar Bukhari2, Rodney L. Braun2, Mark W. Dewhirst2 1The Weizmann Institute of Science, Rehovot, Israel; 2Duke University Medical Center, Durham, NC, USA. 17:24 635.19F MRI Determination of Tumor pO2 During Growth and in Response to Carbogen Breathing Using 15C5-Loaded Alginate Capsules as Oxygen Sensors U. Noth1, L.M Rodrigues1, A. Jork2, J.U.G Streif2, U. Zimmermann2, John R. Griffiths1 1St. George's Hospital Medical School, London UK; 2University of Wurzburg, Wurzburg, Germany. 17:36 636.Analysis of the BOLD Effect in KHT Tumors Following Vasomodulation using Quantitative R2* Maps Patrick Connelly1, Zhong Chen1, Edmund Kwok1, Bruce M. Fenton1, Jianhui Zhong1 1University of Rochester, Rochester, NY, USA. 17:48 637.Correlation of Tumour Pre-Treatment R2* And Carbogen-Induced "R2* With Response To Radiotherapy Loreta Rodrigues1, Franklyn Howe1, John R. Griffiths1, Simon Robinson1 1St. George's Hospital Medical School, London, England, UK. Vessel Wall MR Imaging Forth 16:00 - 18:00Chairs: Zahi A. Fayad Jean-François Toussaint 16:00 638.MRI of Plaque Components and Fibrous Cap Inflammation in Abdominal Aortic Aneurysm Christopher M. Kramer1, Lisa A. Cerilli1, Klaus D. Hagspiel1, Stuart S. Berr1, John N. Oshinski2, Joseph M DiMaria1, Frederick H. Epstein1, John A. Kern1 1University of Virginia, Charlottesville, VA, USA; 2Emory University, Atlanta, GA, USA. 16:12 639.Apparant Vessel Wall Inflammation Detected using MS-325, a Blood Pool Contrast Agent Jeffrey H Maki1, Gregory J Wilson1, Randall B Lauffer2, Robert M Weisskoff2, Chun Yuan3 1Puget Sound VA HCS, University of Washington, Seattle, WA, USA; 2EPIX Medical, Inc., Cambridge, MA, USA; 3University of Washington, School of Medicine, Seattle, WA, USA. 16:24 640.Detection of Macrophage Infiltration in Vulnerable Atherosclerotic Plaque Using Magnetic Resonance Imaging Contrast Media: Super Paramagnetic Iron Oxide (SPIO) Morteza Naghavi1, Mitra Rajabi1, Mohammed Asif1, Michael Quast2, Jingna Wei2, Daniel C.F. Chan3, Mohammad Madjid1, Khawar Gul1, Samuel Ward Casscells Iii1, James T. Willerson1 1University of Texas, Houston Health Science Center, School of Medicine, Houston, TX, USA; 2University of Texas Medical Branch at Galveston, Galveston, TX, USA; 3University of Colorado Health Sciences Center, School of Medicine, Denver, CO, USA. 16:36 641.Contrast Enhanced High Resolution MRI for Atherosclerotic Carotid Artery Tissue Characterization Chun Yuan1, Marina Ferguson2, William Kerwin1, Nayak Polissar3, Jianming Cai4, Thomas S. Hatsukami5 1University of Washington, School of Medicine, Seattle, WA, USA; 2Marina Ferguson, Inc., Seattle, WA, United States; 3The Mountain Whisper Light, Inc., Seattle, WA, USA; 4PLA General Hospital, Beijing, China; 5University of Washington, School of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. 16:48 642.High Resolution MRI of Vulnerable Atheroscerotic Lesions in Excised Human Carotid Arteries Using a Novel Fibrin-Targeted Paramagnetic Nanoparticle Contrast Agent Patrick M. Winter1, Junjie Chen1, Sheng-Kwei Song1, Michael J. Scott1, Ralph W. Fuhrhop1, Jie Tan1, Patrick J. Gaffney2, Gregorio A. Sicard1, Samuel A. Wickline1, Gregory M. Lanza1 Xin Yu1 1Washington University School of Medicine, St. Louis, MO, USA; 2St. Thomas's Hospital, Department of Surgery, London, England, UK. 17:00 643.Phase-Contrast Measurements of Aortic Wall Strain In Vivo Kristin Wedding1, Mary Draney1, Robert J. Herfkens1, C. K. Zarins1, C. A. Taylor1, Norbert J. Pelc1 1Stanford University, Stanford, CA, USA. 17:12 644.High-Resolution Acquisition of Wall Shear Rates Shows Significant Differences between Males and Females Shengping Wu1, Steffen Ringgaard1, Sten Oyre1, Michael Schacht Hansen1, Erik Morre Pedersen1 1Aarhus University Hospital, Aarhus, Denmark. 17:24 645.Contrast Transport in Intracranial Aneurysms Liang-Der Jou1, David Saloner1 1University of California at San Francisco, San Francisco, CA, USA. 17:36 646.The Study of Carotid and Aortic Atherosclerotic Plaques in Humans by In Vivo MR and the Effects of Therapy Roberto Corti1, Badimon J. Juan1, Valentin Fuster1, Stephen G. Worthey1, Gerard Helft1, Zahi A. Fayad1 1Mount Sinai School of Medicine, New York, NY, USA. 17:48 647.The Prevalence and Relevance of MRI High Signal within the Carotid Arteries of Patients with Cerebral Ischaemia R Murphy1, AR Moody1, PS Morgan1, A Martel1, GS Delay1, S Allder1, S MacSweeney2, W Tennant2, J Gladman1, J Lowe1 1University of Nottingham, Nottingham, UK; 2Queen's Medical Centre, Nottingham, UK. fMRI: Animal Models Alsh 16:00 - 18:00Chairs: Mathias Hoehn Annemie van der Linden 16:00 648.Proton MRI Detection of Metabolically Generated H217O from Inhaled 17O2 Dharmesh R. Tailor1, James E. Baumgardner1, John S. Leigh1, Ravinder Reddy1 1University of Pennsylvania School of Medicine, Philadelphia, PA, USA. 16:12 649.Feasibility Studies of 17O MRS Imaging for Fast and Repeatable Measurements of 3D CMRO2 Image in the Rat Brain Xiao-Hong Zhu1, Runxia Tian1, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA. 16:24 650.Observation of Positive and Negative BOLD Signals in Visual Cortex Noam Harel1, Amir Shmuel1, Sang-Pil Lee1, Dae-Shik Kim1, Timothy Duong1, Essa Yacoub1, Xiaoping Hu1, Kamil Ugurbil1, Seong-Gi Kim1 1University of Minnesota Medical School, Minneapolis, MN, USA. 16:36 651.Dynamic CBV Imaging of the Mouse Cortex During Electrical Stimulation of the Hindpaw Thomas Mueggler1, Diana Baumann, Markus Rudin 1Novartis Pharma Ltd, Basel, Switzerland. 16:48 652.Magnetite-Enhanced fMRI Improves CNR Relative to BOLD fMRI in Awake-Behaving Macaque Monkeys at 1.5T David Dubowitz1, Kyle Bernheim1, Dar-Yeong Chen2, William G. Bradley Jr.2, Richard A. Andersen1 1California Institute of Technology, Pasadena, CA, USA; 2Memorial MRI Center, Long Beach, CA, USA. 17:00 653.Region-Specific and Biphasic Dose Dependence of Cocaine-Induced BOLD Signal in Rat Brain Detected by Functional MRI Shi-Jiang Li1, Haiyun Xu1, Gaohong Wu1, Elliot Stein1 1Medical College of Wisconsin, Milwaukee, WI, USA. 17:12 654.Mapping of Dopamine Receptor Hypersensitivity in an Unilateral 6-OHDA model using BOLD Imaging at 7T Dorothee P. Auer1, Gregor-K. Elbel1, Raffael Kalisch1, Marina Delfino2, Michael Czisch1, Juliane Winkelmann1, Gustavo Murer2, Oscar Gershanik2, Claudia Trenkwalder1 1Max Planck Institute of Psychiatry, Munich, Germany; 2Instituto de Investigaciones Farmacologicas, CONICET, Buenos Aires, Argentina. 17:24 655.Involvement of Voltage-Gated Na+ Channels in the BOLD fMRI Response during Forepaw Somatosensory Activation in the Rat Ikuhiro Kida1, Fahmeed Hyder1, Kevin L. Behar1 1Yale University, New Haven, CT, USA. 17:36 656.Function MRI Studies of the Effects of MPTP-Lesions on the Nigrostriatal System of Awake Rhesus Monkeys Zhiming Zhang1, Anders Andersen1, Greg Gerhardt1, Don Gash1 1University of Kentucky, School of Medicine, Lexington, KY, USA. 17:48 657.Negative Functional MRI Changes in Capsaicin-Induced Painful Stimulation in Rats Krisztina Malisza1, Uta Frankenstein1, Patrick Stroman1, John Docherty1 1National Research Council Canada, Winnipeg, MB, Canada. MORNING CATEGORICAL COURSEEmerging Body MRI Applications Hall 1 07:00 - 08:00Chairs: Neil M. Rofsky David J. Lomas Educational ObjectivesUpon completion of this course, participants should be able to Recognize the relevance of recent MRI technology developments to diagnostic imaging of the chest, abdomen, and pelvis. Identify the role of fast imaging sequences in body MRI techniques. Describe new imaging applications for evaluating abnormalities of the abdominal and pelvic organs. Implement new protocols for functional imaging of the lung, pancreas, kidney, prostate, and pelvic floor. Recognize the potential value of new methods for interpreting body MRI data. The final five minutes of each talk will be reserved for questions. 07:00 MRI of the Acute AbdomenFintan Regan 07:30 Volumetric Imaging/InterpretationNeil M. Rofsky MORNING CATEGORICAL COURSEHigh Field Imaging, Spectroscopy, and fMRI Hall 2 07:00 - 08:00Chairs: Arend Heerschap J. Thomas Vaughan Kamil Ugurbil Educational ObjectivesUpon completion of this course, participants should be able to List and explain the advantages of imaging, spectroscopy and fMRI at field strengths of 3T and higher compared to 1.5T and lower. Describe the basic components of a high-field system for clinical imaging and research. Imaging: List clinical imaging methods, applications and research directions enhanced by high-field MRI. Spectroscopy: Appraise spectroscopy as a diagnostic tool at 3T; review research progress at fields to 7T. fMRI: Evaluate the clinical potential of fMRI at 3T and research applications to 7T; explain fMRI contrast mechanisms and their dependency on field strength. Recognize the role(s) of high-field fMRI in the clinic or laboratory. The final 7 minutes of each talk will be reserved for questions. 07:00 High Field Clinical ImagingMatt A. Bernstein 07:30 Highest Field ResearchMichael Garwood MORNING CATEGORICAL COURSEfMRI: What Can We Measure? Hall 5 07:00 - 08:00Chairs: Linda Chang Peter Jezzard Denis Le Bihan Eric C. Wong Educational ObjectivesUpon completion of this course, participants should be able to Describe the current theoretical models for the hemodynamic response to brain activation. Identify those physiological parameters which are accessible to MR measurement. Explain the optimum experimental methods for accessing these parameters. Describe emerging areas of functional MRI methodology. 07:00 Limits to Spatial and Temporal ResolutionRavi S. Menon 07:15 Prospects for Ultra-High Field fMRIKamil Ugurbil 07:30 Other MR Markers for Functional ImagingAlan P. Koretsky 07:45 Discussion MORNING CATEGORICAL COURSEImaging in Sports Medicine Lomond 07:00 - 08:00Chairs: Garry E. Gold Juerg Hodler Educational ObjectivesUpon completion of this course, participants should be able to Use MRI findings to identify mechanisms of joint injury and improve their diagnosis of sports-related abnormalities. Tailor MRI protocols to address sports-related musculoskeletal injuries. Explain the role of MR arthrography in the evaluation of intro-articular injuries. Assess the clinical relevance of sports injuries and correlate MRI findings with surgical treatments. Distinguish trauma-related bone and muscle injuries from neoplastic lesions. 07:00 Hip InjuriesJuerg Hodler 07:25 Spine InjuriesAxel Stabler 07:50 Discussion MORNING CATEGORICAL COURSEImage Reconstruction Forth 07:00 - 08:00Chair: Michael H. Buonocore Educational ObjectivesUpon completion of this course, participants should be able to Describe gridding theory and compare different gridding techniques. Describe the hardware used in real-time imaging. Explain reconstruction techniques used when the usual amount of data is not available. Describe specialized techniques to correct for system imperfections and to reduce effects of noise. The final five minutes of each talk will be reserved for questions. Data Correction 07:00 Off-Resonance, Eddy-Current, Maxwell Corrections and OthersJoseph V. Hajnal 07:30 Navigator Correction TechniquesPeter D. Gatehouse PLENARY LECTURESCurrent and Future Roles for fMRI Clyde Auditorium 08:15 - 09:30Chairs: Peter Jezzard Eric C. Wong Educational ObjectivesUpon completion of this session, participants should be able to Explain new developments in quantitative fMRI. Define the requirements for successful clinical fMRI. Describe the potential contributions of fMRI to neuroscience applications. Identify emerging techniques and applications of fMRI. 8:15 658.Mapping Task-Induced Changes in Cerebral Oxygen Metabolism Richard Hoge Massachusetts General Hospital, Charlestown, MA, USA. 8:40 659.Clinical Applications of fMRI: Bold Claim or Reality? Keith R Thulborn University of Illinois at Chicago, Chicago, IL, USA. 9:05 660.Advancing Our Knowledge of Brain Function and Structure Karl Zilles, N. Jon Shah Institute of Medicine, Research Centre Jülich, Jülich, Germany. fMRI: Neurophysiology and Cognitive Science Clyde Auditorium 10:30 - 12:30Chairs: Steve C.R. Williams Arno Villringer 10:30 661.Effect of Frequency of Vibrotactile Stimulation on the Brain Response Measured Using fMRI Alison Sleigh1, Susan Francis1, Francis Mcglone2, Edward Kelly3, Penny Gowland1, Richard Bowtell1 1University of Nottingham, Nottingham, UK; 2University of Wales, Bangor, UK; 3University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 10:42 662.Brain Activation During Sexual Arousal in Healthy Heterosexual Males Bruce A. Arnow1, J. E. Desmond1, Linda Banner1, Gary H. Glover1, C Abbehusen1, Tom F. Lue2, Scott W. Atlas1 1Stanford University, Stanford, CA, USA; 2University of California, San Francisco, San Francisco, CA, USA. 10:54 663.Acoustic fMRI and Sleep: Negative BOLD Response in the Visual Cortex Michael Czisch1, Christian Kaufmann1, Thomas C. Wetter1, Dorothee P. Auer1 1Max Planck Institute of Psychiatry, Munich, Germany. 11:06 664.Functional MRI of the Retina Timothy Duong1, Dae-Shik Kim1, Kamil Ugurbil1, Seong-Gi Kim1 1University of Minnesota, Minneapolis, MN, USA. 11:18 665.Rate Dependence of Human Visual Cortical Response Due to Transient Stimulation Bahadir Ozus1, Ho-Ling Liu2, Lin Chen3, Meenakshi B. Iyer1, Peter T. Fox1, Jia-Hong Gao1 1University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 2Chang Gung University, Chang Gung Medical Center, Taoyuan, Taiwan; 3University of Science and Technology of China, Beijing, China. 11:30 666.Functional MRI for Validating Neuronavigation of Transcranial Magnetic Stimulation Arthur Wunderlich1, Uwe Herwig1, Carlos Schönfeldt-Lecuona1, Henrik Walter1, Reinhard Jürgen Peter Tomczak2, Manfred Spitzer1, Hans-Jürgen Brambs1 1Universitaet Ulm - Klinikum, Ulm, Germany; 2University of Ulm, Ulm, Germany. 11:42 667.Brain Areas Specific for Attentional Load in a Motion Tracking Task Jorge Jovicich1, Robert J. Peters1, Christof Koch1, Jochen Braun1, Linda Chang2, Thomas Ernst3 1California Institute of Technology, Pasadena, CA, USA; 2Brookhaven National Laboratory, Upton, NY, USA; 3Harbor-UCLA Medical Center, Torrance, CA, USA. 11:54 668.An fMRI Analysis of Driving-Related Networks with Independent Component Analysis Applied in a Between-Condition (BC-ICA) and Within-Condition (WC-ICA) Manner Vince Calhoun1, James Pekar1, Tulay Adali2, Godfrey Pearlson1 1Johns Hopkins University, Baltimore, MD, USA; 2University of Maryland Baltimore County, Baltimore, MD, USA. 12:06 669.Cortical Basis of Phonological Effects in Reading Words: A fMRI Study of Written Chinese Ching-Mei Feng1, Li Hai Tan2, Peter T. Fox1, Jia-Hong Gao1 1University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 2University of Hong Kong, Hong Kong, P.R. China. 12:18 670.Cross-Modal Plasticity in Congenitally Blind Subjects Rupert Lanzenberger1, Frank Uhl1, Christian Windischberger2, Andreas Gartus1, Bernhard Streibl1, Vinod Edward1, Ewald Moser2, Lüder Deecke1, Roland Beisteiner1 1Department of Clinical Neurology, Vienna, Austria; 2Universitat Wien, Vienna, Austria. Animal Brain: A Potpourri Lomond 10:30 - 12:30Chairs: Klaas Nicolay James R. Ewing 10:30 671.Revealing Neuronal Substates of Epileptogenesis by Multiparametric MRI in a Rat Model of Temporal Lobe Epilepsy Jaak Nairismagi1, Olli Gröhn1, Mikko Kettunen1, Jari Nissinen1, Asla Pitkanen1, Risto Kauppinen1 1University of Kuopio, Kuopio, Finland. 10:42 672.MRI Studies of the Pathogenesis of Transmissible Spongiform Encephalopathy in a Mouse Model of Scrapie Y-L Chung1, A Williams2, S Rebus2, K K Changani1, S C R Williams3, J D Bell1 1Imperial College School of Medicine, Hammersmith Hospital, London, UK; 2Glasgow University Veterinary School, Glasgow, UK; 3Institute of Psychiatry, London, UK. 10:54 673.GABAergic Regulations on Heroin-Induced Activation in Rat Brain Detected by Functional MRI Shi-Jiang Li1, Zheng-Xiong Xi1, Gaohong Wu1, Elliot Stein1 1Medical College of Wisconsin, Milwaukee, WI, USA. 11:06 674.Chronic Expression of TNF-að in the Rat Brain causes Changes in Cerebral Perfusion, Tissue Water Diffusion and Blood-Brain Barrier Permeability as determined by MRI Nicola Sibson1, Andrew Blamire1, V. H. Perry2, Peter Styles1, D. C. Anthony2 1University of Oxford, Oxford, England, UK; 2University of Southampton, Highfield, Southampton, UK. 11:18 675.Stress Response in the Brain of a Common Carp Submitted to a Sublethal Cold Shock as Measured by BOLD and CBV Sensitive fMRI R. R. Peeters1, E. H. Van den Burg2, G. Flik2, S. E. Wendelaar Bonga2, A. Van der Linden1 1Bio-Imaging Lab RUCA, Antwerp, Belgium; 2University of Nijmegen, Nijmegen, Netherlands. 11:30 676.Magnetic Resonance Imaging of Spontaneous Hemorrhagic Stroke in Conscious Rats Mathew E. Brevard1, Jean A. King2, Mark Mattingly3, Gang Zhu3, David Olson2, Robert M.K.W. Lee4, Craig F. Ferris2 1University Massachusetts Medical Center, Worcester Polytechnic Institute, Worcester, MA, USA; 2University of Massachusetts Medical School, Worcester, MA, USA; 3Bruker Medical, Billerica, MA, USA; 4McMaster University, Hamilton, Ontario, Canada. 11:42 677.Metabolic Changes Induced by Hypoxia and Lactate in the Brain of the Amphibian Bufo marinus, Observed with Flow Weighted and T2* Weighted MR Imaging Christian Bock1, Ilka Pinz1, Hans-Otto Pörtner1 1Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Germany. 11:54 678.Cerebroprotection by Delayed Hypothermia after Perinatal Asphyxia shown by Diffusion-Weighted Imaging John Thornton1, Frances O'Brien1, Keith Brooks1, Yasuko Sakata1, Nicola Parker1, Phillip Amess1, Martina Noone1, Mark Sellwood1, Ernest Cady1, Matthew Clemence2, Quyen Nguyen1, Marzena Wylezinska3, John Wyatt1, Roger Ordidge1 1University College London, London, UK; 2University of Exeter, Exeter, UK; 3University of Oxford, Oxford, UK. 12:06 679.Deferoxamine Enhances Postresuscitative Cerebral Reperfusion After Prolonged Cardiac Arrest Serguei M Liachenko1, Pei Tang1, Yan Xu1 1University of Pittsburgh, Pittsburgh, PA, USA. 12:18 680.Monitoring USPIO Accumulation in Ischemic Brain Tissue of Rats after Permanent MCAO Martin Rausch1, Andre Sauter1, Johannes Fröhlich2, Markus Rudin1 1Novartis Pharma AG, Basel, Switzerland; 2Guerbet AG, Zürich, Switzerland. Other MR Imaging Sequences Hall 2 10:30 - 12:30Chairs: Dennis L. Parker Michael L. Wood 10:30 681.A Genetic Algorithm for Opitmal Design of Spectrally Selective k-Space Douglas C. Noll1 1University of Michigan, Ann Arbor, MI, USA. 10:42 682.Optimal Sampling for 3D Projection Reconstruction Imaging Benjamin S. Wilbur1, Khader M. Hasan1, Andrew L. Alexander1, Dennis L. Parker1 1University of Utah, Salt Lake City, UT, USA. 10:54 683.Signal and Contrast in Prepolarized MRI: First Data Steven Conolly1, Blaine Chronik1, Nathaniel Ivan Matter1, Patrick N. Morgan2, Hao Xu1 1Stanford University, Stanford, CA, USA; 2Texas A&M University, College Station, TX, USA. 11:06 684.Electric Current Density Imaging of Chemical Reactions Ursa Mikac1, Alojz Demsar2, Igor Sersa1, Franci Demsar1 1Jozef Stefan Institute, Ljubljana, Slovenia; 2Universiry of Ljubljana, Ljubljana, Slovenia. 11:18 685.Current Densities Produced by Surface Electrodes: Comparison of MRI measurements and Finite Element Modeling Tim P. Demonte1, Andrei Patriciu2, Michael L.G. Joy1, Johannes J. Struijk2 1University of Toronto, Toronto, Canada; 2Aalborg University, Denmark. 11:30 686.Study of Current Pathways in Porcine Heart using Current Density Imaging Richard S. Yoon1, Tim P. Demonte1, Dawn Jorgenson2, Michael L.G. Joy1 1University of Toronto, Toronto, Ontario, Canada; 2Agilent Technologies, Seattle, WA USA. 11:42 687.Design of Null Pulses for use in Pulsed Arterial Spin Labeling by the Principle of Time Reversal Gerald Matson1, Thomas Schleich2 1University of California, San Francisco, S.F. V.A. Medical Center, San Francisco, CA, USA; 2University of California, Santa Cruz, Santa Cruz, CA, USA. 11:54 688.Non-Linear Phase RF Pulses for Reduced Dynamic Range in 3D RARE Imaging John M. Pauly1, Eric Wong2 1Stanford University, Stanford, CA, USA; 2University of California, San Diego, La Jolla, CA, USA. 12:06 689.Shortening Multiband RF Pulse Duration for Reduced Motion Sensitivity Charles H. Cunningham, Graham A. Wright and Michael L. Wood1 1University of Toronto, Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada. 12:18 690.Improving Dynamic Range in 3D MRI with RF Pulses Producing Quadratic Phase Lance DelaBarre1, Patrick J. Bolan1, Michael Garwood1 1University of Minnesota, Minneapolis, MN, USA. RF Methods and Modeling Hall 5 10:30 - 12:30Chairs: Gregor Adriany Mark A. Griswold 10:30 691.A Parallel Technique for the Inverse Design of RF Coils Ben Gerard Lawrence1, Desmond Yau, Stuart Crozier, Kurt Luescher, Wolfgang Roffmann, David Doddrell 1University of Queensland, Brisbane, Queensland, Australia. 10:42 692.Obtaining a Homogeneous B1 Field at UHF Frequencies: Use of Multiple Drives and Variable Amplitude/Phases Tamer Ibrahim1, Robert Lee1, Brian Baertlein1, Pierre-Marie L. Robitaille1 1Ohio State University, Columbus, OH, USA. 10:54 693.Electromagnetic Characterisation of RF Coils using the Transmission Line Modelling (TLM) Method Paul J Cassidy1, Stuart Grieve1, Kieran Clarke1, David J Edwards1 1University of Oxford, Oxford, England, UK. 11:06 694.Calculated SNR and Absorbed RF Power with Field Strength and Definition of RF Excitation Pulse Christopher M. Collins1, Michael B. Smith1 1Penn State College of Medicine, Hershey, PA, USA. 11:18 695.Minimally Invasive Probing of B1 Field Distributions in MR Coils using Infrared Sensors Tamer Ibrahim1, Brian Baertlein1, R. Lee1, R. D. Gilbert1, Robert Lee1, Amir Abduljalil1, Pierre-Marie L. Robitaille1 1Ohio State University, Columbus, OH, USA. 11:30 696.Perfectly Sinusoidal SMASH Field Shapes from Birdcage Sectors J. Willig1, R. Brown1, T. Eagan1, Sh. Shvartsman2 1Case Western Reserve University, Cleveland, OH, USA; 2Marconi Medical Systems, Inc., Cleveland, OH, USA. 11:42 697.Quantitative Mapping of RF Magnetic Fields using Spectral Methods Dan Spence1, Mary Preston McDougall1, Steven M. Wright1 1Texas A&M University, College Station, TX, USA. 11:54 698.Analysis of the RF Field of a Quadrature Surface Coil at 7.0T Jinghua Wang1, Qing X. Yang1, Christopher M. Collins1, Michael B. Smith1, Xiaoliang Zhang2, Gregor Adriany2, Haiying Liu2, Xiao-Hong Zhu2, J. Thomas Vaughan2, Kamil Ugurbil2, Wei Chen2 1Hershey Medical Center, Pennsylvania State University, Medicine, Hershey, PA, USA; 2University of Minnesota, Minneapolis, MN, USA. 12:06 699.Analysis of Single Microstrip Resonator with Capacitive Terminational at Very High Fields Xiaoliang Zhang1, Robert Sainati1, Thomas Vaughan1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA. 12:18 700.Closed Loop Feedback Control of Microwave Heating using MRI Babak Behnia1, Andrew Webb1 1University of Illinois at Urbana-Champaign, Urbana, IL, USA. Body MR Imaging: Ex Vivo and Animal Models Hall 1 10:30 - 12:30Chairs: Pottumarthi V. Prasad Donald S. Williams 10:30 701.Sinusoidal Permeability Changes in Liver Fibrosis: Assessment with Contrast-Enhanced MR Imaging Bernard E Van Beers1, Roland Materne1, Anne M Smith1, Christine Sempoux1, Yves Horsmans1 1Université catholique de Louvain, Cliniques universitaires St-Luc, Brussels, Belgium. 10:42 702.Functional MRI Demonstrates Reduced Hepatic Blood Oxygenation During Intestinal Ischaemia - Reperfusion Jane Utting1, Paisarn Vejchapipat2, D. L. Thomas2, E. Proctor2, Agostino Pierro2, David Gadian2, Roger Ordidge1 1University College London, London, England, UK; 2Institute of Child Health, London, England, UK. 10:54 703.Hepatic Oxygenation Changes in Chronic Ethanol-Treated Rats Analysed by fMRI Lesley May Foley1, Melissa Jamie Yau1, R. Terry Thompson2, Manfred Brauer1 1University of Guelph, Guelph, ON, Canada; 2University of Western Ontario, St. Joseph's Hospital, London, ON, Canada. 11:06 704.Preliminary Evaluation of EVP-ABD as a Liver Contrast Agent Exhibiting Both a Vascular and a Tissue Phase Pippa Storey1, Wei Li1, Peter Seoane2, Phillip Harnish2, Pottumarthi Prasad1 1Evanston Hospital, Northwestern University Medical School, Evanston, IL, USA; 2Eagle Vision Pharmaceutical Corp, Chester Springs, PA, USA. 11:18 705.The Quantitative Evaluation of Liver Function Using Gd-EOB-DTPA: Deconvolution Analysis Yongmin Chang1, Hun-Kyu Ryeom1, Bong-Soo Han1, Hyun-Jung Park1, Kyung-Eun Song1, Duk-Sik Kang1 1Kyungpook National University Hospital, Taegu, Korea. 11:30 706.Unesterified Cholesterol and Magnetization Transfer MRI in Livers of Mice with Niemann-Pick Type C Disease Jingyu Guo1, Theodore Trouard1, Jean-Philippe Galons1, Robert Erickson1, Robert Gillies1 1University of Arizona, Tucson, AZ, USA. 11:42 707.Efficacy of Ferucarbotran on T1 Weighted Images In Vitro and In Vivo Study Naoki Kato1, Tomoaki Miyazawa1, Satoshi Yoshise1, Taro Takahara2, Masao Obuchi3, Akihiro Tanimoto4, Takashi Yokawa1 1Nihon Schering K. K., Osaka, Japan; 2Kyorin University, Toyko, Japan; 3Showa University Fujigaoka Hospital, Yokohama, Japan; 4Keio University Hospital, Tokyo, Japan. 11:54 708.An In Vivo Validation Study of Body Composition in Rats Using High Resolution MRI Haiying Tang1, Ed X. Wu1, Dympna Gallagher2, Joseph R. Vasselli2, Carol N. Boozer2 1Columbia University, New York, NY, USA; 2St. Luke's-Roosevelt Hospital, New York, NY, USA. 12:06 709.The Normal Adrenal Cortex: In Vitro High Resolution Chemical Shift MRI Donald Gordon Mitchell1, Alessandra Bettega Nascimento2, Faiyaz Alam, Ralf P Grasel3, Brian J O'Hara1 1Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA, USA; 2Universidade Federal do Parana', Philadelphia, PA, USA; 3Brazil. 12:18 710.Quantitative Testicular Perfusion MRI using Continuous Arterial Spin-Labeling E. Scott Pretorius1, D. A. Roberts1, S. Dheer1, Mitchell Schnall1 1University of Pennsylvania, Philadelphia, PA, USA. Cardiac MR Spectroscopy: Preclinical and Clinical Forth 10:30 - 12:30Chairs: Steven D. Buchthal Jan A. den Hollander 10:30 711.Combined Analysis of Several 31P NMR Inversion Transfer Protocols: A New Strategy to Assess Subcellular Energy Transfer Fluxes in the Perfused Rat Heart. Frédéric Joubert1, Philippe Mateo, Jean Luc Mazet 1Université Paris Sud, Faculté de Pharmacie, Chatenay Malabry, France. 10:42 712.Differential Effect of bð1- vs bð2- Adrenergic Receptor Stimulation on Bioenergetics and Work Rate in the Isolated, Perfused Rat Heart Patrick McConville1, Kenneth W. Fishbein1, Edward G. Lakatta1, Richard G. S. Spencer1 1NIH/National Institute on Aging, Baltimore, MD, USA. 10:54 713.Myoglobin Scavenges Bioactive NO in Muscle Assessed by 1H NMR Spectroscopy Ulrich Flögel1, Marc W. Merx1, Axel Gödecke1, Ulrich K.M. Decking1, Jürgen Schrader1 1Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany. 11:06 714.Ischemic Preconditioning Activates Mitochondrial but not Sarcolemmal ATP-sensitive Potassium Channels in Intact Rat Hearts: 87Rb NMR Study. Olga Jilkina1, Bozena Kuzio2, Valerie Kupriyanov2 1University of Manitoba, Winnipeg, MB, Canada; 2National Research Council, Winnipeg, MB, Canada. 11:18 715.Phosphorus-31 Magnetic Resonance Spectroscopic Imaging (31P MRSI) in Patients with Hereditary Hemochromatosis Michael F.H. Schocke1, Bernhard Metzler1, Christian Wolf1, Steinboeck Peter1, Wolfgang Vogel1, Pachinger Otmar1, Jaschke Werner1 1University of Innsbruck, Innsbruck, Tyrol, Austria. 11:30 716.Cardiac 31P MRS Identifies Ischemia in Twenty Percent of Women with Chest Pain but No Significant Angiographic Stenosis Hee-Won Kim1, Katherine N. Scott1, Angela P. Bruner1, Steven Buchthal2, Jan Den Hollander2, Gerald M. Pohost2, Carl J. Pepine1 1University of Florida, Gainesville, FL, USA; 2University of Alabama at Birmingham, Birmingham, AL, USA. 11:42 717.Volume Tracking Using Multiple Navigator Echoes in Cardiac 31P Spectroscopy Sebastian Kozerke1, Hildo J Lamb2, Peter Boesiger1 1University and ETH, Zurich, Switzerland; 2Leiden University Medical Center, Leiden, The Netherlands. 11:54 718.3D Density-weighted Chemical Shift Imaging (denCSI) to Map 31P Metabolites of the Human Heart Andreas Greiser1, Axel Haase1, Markus Von Kienlin2 1Universität Würzburg, Würzburg, Germany; 2Hoffmann-La Roche Pharmaceuticals, Basel, Switzerland. 12:06 719.Coenzyme Q10 plus Vitamin E Treatment of Patients with Friedreich Ataxia. A 24 Month Clinical and MRS Follow Up Study. R. Lodi1, A. H. Schapira2, B. Rajagopalan3, D. J. Taylor3, P. Hart2, J. G. Crilley3, J. L. Bradley2, A. M. Blamire3, D. Manners3, P. Styles3, J. M. Cooper2 1Università di Bologna, Bologna, Italy; 2Royal Free Hospital, London, UK; 3University of Oxford, Oxford, UK. 12:18 720.The Mitochondrial ATPase and High Energy Phosphates in Failing Hearts Jay Zhang1, J. Liu1, Robert J Bache1, Kamil Ugurbil1 1University of Minnesota, Minneapolis, MN, USA. The Tumor Microenvironment Alsh 10:30 - 12:30Chairs: Natarajan Raghunand Sebastian Cerdán 10:30 721.Choline Kinase Activity Modulates Proton Extrusion in Precarcinogenic Livers M. L. García-Martín1, M. A. García-Espinosa1, P. Ballesteros2, S. Cerdán1 1Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, Madrid, Spain; 2U.N.E.D., Madrid, Spain; 10:42 722.Enhanced Expression Of Metastasis Suppressor Gene May Play A Role In Phospholipid Changes In Breast Cancer Cells Following Treatment With An Anti-Inflammatory Agent Indomethacin Kshama Natarajan1, Noriko Mori1, Dmitri Artemov1, Zaver Bhujwalla1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA. 10:54 723.MRS Detects Alterations in Lipid Metabolism during Apoptosis Nada Al-Saffar1, Jennifer Titley1, David Robertson1, Elizabeth Jackson1, Paul Clarke1, Martin Leach1, Sabrina Ronen1 1The Royal Marsden NHS Trust, Sutton, Surrey, UK. 11:06 724.Combined 1H MR Spectroscopic Imaging Of Extracellular pH And Metabolites In Rat Glioma : High Lactate Is Not Associated With Lower Extracellular pH Marisa Garcia-Martin1, Gwenaël Herigault2, Chantal Rémy2, Régine Farion2, Paloma Ballesteros1, Jonathan Coles2, Sebastian Cerdan1, Anne Ziegler2 1CSIC, Instituto de Investigaciones Biomedicas, Madrid, Spain; 2INSERM U438 / Université J. Fourier, CHU de Grenoble, Grenoble, France. 11:18 725.Combined Optical and Magnetic Resonance Microscopy of Heterogeneous JB6 Tumor Spheroid Populations Paul D. Majors1, Thomas J. Weber1, Gary R. Holtom1, Kevin R. Minard1, Robert A. Wind1 1Pacific Northwest National Laboratory, Richland, WA, USA. 11:30 726.Differentiation of Tumor Recurrence from Treatment-Induced Necrosis Using Quantitative Diffusion MRI Xiaohong Joe Zhou1, Norman E. Leeds1, Ashok J. Kumar1, June Chong1, Victor A. Levin1 1M.D. Anderson Cancer Center, Houston, TX, USA. 11:42 727.Endothelial Cells Promote Cancer Cell Invasion under Hypoxia Ellen Ackerstaff1, Dmitri Artemov1, Robert Gillies2, Zaver Bhujwalla1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2University of Arizona, Arizona Health Science Center, Tucson, AZ, USA. 11:54 728.Physiolgical Mechanisms Underlying the MR-visible Acidic pH of Tumors Paul A. Schornack1, Robert J. Gillies1 1University of Arizona, Arizona Health Sciences Center, Tucson, AZ, USA. 12:06 729.The Use of Contrast Enhanced MRI to Guide Functional Genomic Microarray Analysis in Tumors Samira Guccione1, Yi-Shan Yang1, King C. Li1, Mark Bednarski1 1Stanford University, Stanford, CA, USA. 12:18 730.Acute Vascular Response to VEGF: Vasodilation, Hyperpermeability, Increased Lymphatic Uptake and Growth Factor Inactivation (MRI and Confocal Mycroscopy) Hagit Dafni1, Bilha Schechter1, Fortune Kohen1, Michal Neeman1 1Weizmann Institute of Science, Rehovot, Israel. POSTER SESSIONS Hall 4Monday: 14:00 – 16:00Tuesday-Thursday: 13:30 – 15:30 YOUNG INVESTIGATORS AWARD FINALISTS Poster 4 and 5 will also be presented in the oral session Image Reconstruction Methods on Monday, 23 April, 2001 at 11:00 in the Clyde Auditorium. T4.Young Investigator Awards Finalist: Advances in Sensitivity Encoding with Arbitrary k-Space Trajectories Klaas Paul Pruessmann1, Markus Weiger1, Peter Börnert2, Peter Boesiger1 1ETH and University Zurich, Zurich, Switzerland; 2Philips Research, Hamburg, Germany. T5.Young Investigator Awards Finalist: Unifying Linear Prior-information-driven Methods for Accelerated Image Acquisition — Development of a Broad-use Linear Acquisition Speed-up Technique (BLAST) to Overcome Existing Limitations Jeffrey Tsao1, Babak Behnia1, Andrew Webb1 1University of Illinois at Urbana-Champaign, Urbana, IL USA. Poster 118 will also be presented in the oral session Image Processing Brain on Monday, 23 April, 2001 at 16:30 in Hall 5. T118.Young Investigator Awards Finalist: 4D Deformation Modeling of Cortical Disease Progression in Alzheimers Dementia Andrew Janke1, Greig De Zubicaray1, Stephen E. Rose1, Mark Griffin1, Johnathan B Chalk Jr1, Graham J. Galloway1 1University of Queensland, Brisbane, Queensland, Australia. Poster 180 will also be presented in the oral session MR Imaging of the Thorax on Tuesday, 24 April, 2001 at 10:30 in Hall 5. W180.Young Investigator Awards Finalist: Dynamic Spiral MR Imaging of the Lung Using Hyperpolarized 3He: Initial Experience in Healthy and Diseased Lungs Michael Salerno1, Talissa A. Altes1, James R. Brookeman1, Eduard E. De Lange1, John P. Mugler III1 1University of Virginia, School of Medicine, Charlottesville, VA, USA. Poster 289 will also be presented in the oral session Motion and Artifact Correction on Tuesday, 24 April, 2001 at 16:00 in the Lomond. W289.Young Investigator Awards Finalist: PROPELLER MRI: Clinical Testing of a Novel Technique for Quantification and Compensation of Head Motion Kirsten P Forbes1, James G Pipe1, Roger Bird1, Joseph E Heiserman1 1Barrow Neurological Institute, St Josephs Hospital and Medical Center, Phoenix, AZ, USA. Poster 341 will also be presented in the oral session fMRI: Noise Processes and Signal Recovery on Wednesday, 25 April, 2001 at 10:30 in the Clyde Auditorium. M341.Young Investigator Awards Finalist: The Physiological Noise in Oxygenation-Sensitive Magnetic Resonance Imaging Gunnar Krueger1, Gary H. Glover1 1Stanford University, Stanford, CA, USA. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Artifact Reduction Lomond Monday: 14:00 - 16:00 Chairs: David Atkinson Charles Mistretta 14:00 731.Inverse MRI: Imaging a Freely Rotating Object Kate McLeish1, David Atkinson1, Derek Hill1, Stephen Keevil1 1Guy's, King's and St. Thomas' School of Medicine, London, England, UK. 14:10 732.An Intelligent Real Time Navigator Control System for MRI Jeffrey Bezanson1, Richard Watts1, Thanh Nguyen1, Martin R. Prince1, Yi Wang1 1Cornell University, New York, NY, USA. 14:20 733.DTI using an Improved Segmented EPI Protocol Anders Franck1, Sara Brockstedt2, Jimmy Lätt3, Stefan Skare4, Freddy Ståhlberg3 1Huddinge University Hospital, Huddinge, Sweden; 2Lund University Hospital, Lund, Sweden; 3The Jubileum Institute, Lund, Sweden; 4Karolinska Hospital, Stockholm, Sweden. 14:30 734.Motion Artefact Reduction using SMASH Mark Bydder1, David J Larkman1, Joseph V Hajnal1 1Imperial College, School of Medicine, Hammersmith Hospital, London, UK. 14:40 735.Dynamic View Ordering (DVO) FSE for Reduced Artifacts James G. Pipe1 1Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. 14:50 736.Correction of Eddy Currents in EPI-based Diffusion Tensor Imaging Aziz Hatim Poonawalla1, Xiaohong Joe Zhou1 1University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. 15:00 737.Correcting for Translational Motion in 3D Projection Reconstruction Oliver Wieben1, Andrew V. Barger1, Walter F. Block1, Charles A. Mistretta1 1University of Wisconsin-Madison, Madison, WI, USA. 15:10 738.Correction of Slab Boundary Artifact using Histogram Matching Eugene Kholmovski1, Andrew L Alexander1 1University of Utah, Salt Lake City, UT, USA. 15:20 739.A Simple Technique for Reducing Aliasing Artifacts in Projection Reconstruction MRI Hee Kwon Song1 1University of Pennsylvania Medical Center, Philadelphia, PA, USA. 15:30 740.Deblurring of Multiphase Spiral 3D CE-MRA Date: Dynamic Changes of Susceptibility During Contrast Media Transit Michael Amann1, Michael Bock1, Lothar Schad1 1Deutsches Krebsforschungszentrum, Heidelberg, Germany. 15:40 741.Reduction of the Blurring Artifacts due to the Local Field Inhomogeneity in Spiral Imaging Qing Yang1, Victor Stenger2, Michael B. Smith1, Fernando Boada2, Douglas Noll3 1The Penn State College of Medicine, Hershey, PA, USA; 2University of Pittsburgh, Medical Center, Pittsburgh, PA, USA; 3University of Michigan, Ann Arbor, MI, USA. 15:50 742.Higher Order Geometrical Distortion in Serial MR Brain Imaging Mark Holden1, Marcel Breeuwer2, Kate McLeish1, David J Hawkes1, Stephen Keevil1, Derek LG Hill1 1King's College London, London, UK; 2Philips Medical Systems, Best, Netherlands. Motion and Artifact Correction Hall 4 Tuesday: 13:30 - 15:30 743.Improved In-Plane Motion Correction for PROPELLER MRI James G. Pipe1 1Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. 744.Motion Correction from Orthogonal k-Space Phase Difference Edward Brian Welch1, Armando Manduca1 1Mayo Clinic, Rochester, MN, USA. 745.Dash Artifact Associated with Sinusoidal Frequency Encoding Gradient and Coherent Noise Weiliang Du1, Xiaobing Fan, Gregory Karczmar 1University of Chicago, Chicago, IL, USA. 746.Application of RF Subencoding Acquisition to Flow Compensated 3D half-Fourier FSE MRA Yoshio Machida1, Miguel Angel Gonzalez Ballester1, Hiroshi Takai1, Yoshimori Kassai1, Yoshinori Hamamura1 1Medical Systems R&D Center, Toshiba, Otawara, Tochigi Japan; 747.Automatic Motion Correction Using Prior Knowledge David Atkinson1, Derek Hill1 1Guy's Hospital, London, England, UK. 748.Delineation of an Acquisition Window within the Respiratory Cycle of Laboratory Animals Shannon P Holmes1, Micheal Thornton1, Paula Gareau1, David W Holdsworth1 1The John P. Robarts Research Institute, London, ON, Canada. 749.Previewing during Coronary Artery Examinations based on Motion-Adapted Gating Holger Eggers1, Lars Steen2, Ralph Sinkus1, Peter Boesiger3 1Philips Research, Hamburg, Germany; 2University of Applied Sciences Hamburg, Hamburg, Germany; 3Swiss Federal Institute of Technology Zurich and University of Zurich, Zurich, Switzerland. 750.Motion Correction of Single-Shot Multi-Echo fMRI Data Oliver Speck1, Jürgen Hennig1 1University Medical Center Freiburg, Freiburg, Germany, 751.Amplitude-Adaptive Filtering of Respiration Noise in fMRI Data Ulas Ziyan1, Jared R. Brosch1, Thomas M. Talavage1 1Purdue University, West Lafayette, IN, USA. 752.Estimation and Correction of Rotation Induced Artifacts using Autocorrection and A Linear Distortion Model Kiaran P. McGee1, Joel P. Felmlee1, Clifford R. Jack Jr.1, Armando Manduca1, Richard L. Ehman1 1Mayo Clinic, Rochester, MN, USA. 753.Navigation of the Heart with Single-Shot Images Bernd A. Jung1, Axel Haase2, Peter M. Jakob2 1Albert-Ludwig-Universität Freiburg, Freiburg, Germany; 2University of Würzburg, Würzburg, Germany. 754.Magnetic Susceptibility Quantitation for Arbitrarily-Shaped Objects in Inhomogeneous Fields Lin Li1 1University of Pennsylvania, Philadelphia, PA, USA. 755.Optimal Polarization States for Radiofrequency Fields in Magnetic Resonance Imaging R. H. Weening1, Felix Wehrli1 1University of Pennsylvania, Philadelphia, PA, USA. 756.Correction of Distortions in Non-Axial Echo Planar Imaging J. Y. Chiou1, O. Nalcioglu1 1University of California, Irvine, CA, USA. 757.Automatic Elimination of a Ringing Artefact Introduced by Eddy Current Correction Arjan W. Simonetti1, Willem J. Melssen1, Marinette Van Der Graaf2, Arend Heerschap2, Lutgarde M.C. Buydens1 1Nijmegen University, Nijmegen, Netherlands; 2University Hospital Nijmegen, Nijmegen, Netherlands. 758.Correction of K-Space Mapping Errors in Phase Encoding Direction Yong-Gwon Kim1, Chang-Hyun Oh2, Sun-Kyung Kim1, Sung-Taek Chung1, Yun-Jeong Yang3, Yong-Hyun Kim1 1MEDINUS MRI Research Center, Seoul, South Korea; 2Korea University, Chochiwon-Chungnam, S. Korea; 3Korea University, Seoul, South Korea. 759.Correction for Artifacts in 3D Angularly Undersampled MR Projection Reconstruction Sean B. Fain1, Walter Block1, Andrew Barger1, Charles A. Mistretta1 1University of Wisconsin-Madison, Madison, WI, USA. 760.Spike Removal in EPI Data for fMRI Xiaodong Zhang1, Pierre-Francois Van De Moortele1, Josef Pfeuffer1, Kamil Ugurbil1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. Various Image Reconstruction Techniques Hall 4 Tuesday: 13:30 - 15:30 761.A Model for Time-Resolved Contrast-Enhanced Magnetic Resonance Angiography Frank Wajer1, Dirk Van Ormondt1, Miha Fuderer2, Johan Van Den Brink2, R. de Beer1 1Delft University of Technology, Netherlands; 2Philips Medical Systems, Best, Netherlands. 762.Time Resolved MRA with Continuous Acquisition of the k-space Center Alain Herment1, Elie Mousseaux2, Elodie Roullot3, Isabelle Bloch3, Odile Jolivet4, Jacques Bittoun4 1CHU Pitie-Salpetriere, Paris, France; 2Hopital Broussais, Paris, France; 3ENST, Paris, France; 4Hôpital de Bicêtre, Le Kremlin-Bicêtre, France. 763.A Min-Max Approach to the Nonuniform N-Dimensional FFT for Rapid Iterative Reconstruction of MR Images Bradley Sutton1, Jeffrey A. Fessler1, Douglas Noll1 1University of Michigan, Ann Arbor, MI, USA. 764.Super-Resolved MRI by Back-Projection Dimitrios Mitsouras1, Alan Edelman1, Lawrence P. Panych2, Ferenc A. Jolesz2, Gary P. Zientara2 1Massachusetts Institute of Technology, Cambridge, MA, USA; 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 765.An Iterative Regularized Algorithm for Tensor Tomography in MRI Vladimir Y Panin1, G Larry Zeng1, Grant T Gullberg1, Andrew Alexander1, Dennis L Parker1 1University of Utah, Salt Lake City, UT, USA. 766.31P awCSI Metabolite Maps of the Human Heart by Time Domain Fitting of Multidimensional In Vivo Spectroscopic MR Data Andreas Greiser1, Axel Haase1, Markus Von Kienlin2 1Universität Würzburg, Würzburg, Germany; 2Hoffmann-La Roche Pharmaceuticals, Basel, Switzerland; Image Reconstruction from Coil Arrays Hall 4 Tuesday: 13:30 - 15:30 767.Major Speedup of Reconstruction for Sensitivity Encoding with Arbitrary Trajectories Frank Wajer1, Klaas Pruessmann2 1Delft University of Technology, Delft, Netherlands; 2University and ETH Zurich, Zürich, Switzerland. 768.Optimization of Parallel Imaging By Use of Selective Excitation Walid Kyriakos1, Lawrence Patrick Panych2 1Harvard University, Children's Hospital, Boston, MA USA; 2Harvard University, Harvard Medical School, Boston, MA, USA. 769.Generalized Parallel Imaging Using Array Coil Encoding Jianmin Wang1 1Siemens Medical Engineering, Erlangen, Germany. 770.kSENSE: k-Space Sensitivity Encoding Reconstruction Keith Heberlein1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 771.Iterative MR Image Reconstruction Using Sensitivity and Inhomogeneity Field Maps Bradley Sutton1, Jeffrey A. Fessler1, Douglas Noll1 1University of Michigan, Ann Arbor, MI, USA. 772.2-way SMASH Joseph V Hajnal1, Mark Bydder1, David J Larkman1 1Imperial College School of Medicine, Hammersmith Hospital, London, UK. 773.Use of Information Theory to Align Separately Acquired Reference and Target Data for SENSE Processing Mark Bydder1, David J Larkman1, Joseph V Hajnal1 1Imperial College School of Medicine, Hammersmith Hospital, London, England, UK. 774.Adaptive Coil Selection in Reconstructing Phased Array Images Jingfei Ma1, Dharanesh Halliyur1, Lloyd Estkowski1, Ricardo Becerra1 1G. E. Medical Systems, Milwaukee, WI, USA. Image Reconstruction: Gridding and Novel Sampling Hall 4 Tuesday: 13:30 - 15:30 775.Artifact-Free, Maximal-SNR, Efficient Image Combination for Coronary MR Using the Correlation Coefficient Template Grid Matching Technique M.S. Sussman, N. Robert, G.A. Wright1 1Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. 776.Simple Formula for the Accuracy of Gridding Frank Wajer1, Ralf Lethmate2, J.A.C. Van Osch1, Danielle Graveron-Demilly2, Miha Fuderer3, Dirk Van Ormondt1 1Delft University of Technology, Delft, Netherlands; 2Université Claude Bernard Lyon 1, Villeurbanne, France; 3Philips Medical Systems, Best, Netherlands. 777.A Modified Block Uniform Resampling (BURS) Algorithm using Truncated Singular Value Decomposition: Fast Gridding with Noise Reduction Hisamoto Moriguchi1, Jeffrey L. Duerk1 1Case Western Reserve University / University Hospitals of Cleveland, Cleveland, OH, USA. 778.Keyhole/RIGR Dynamic Imaging using Deformable References Xiuquan Ji1, Qiao Jia Zeng1, Zhi-Pei Liang1 1University of Illinois at Urbana-Champaign, Urbana, IL, USA. 779.Neuman Expansion in Real Variables, An Example of a Bandwidth Limited Expansion Mirko I. Hrovat1, Samuel Patz2 1Mirtech, Inc., Brockton, MA, USA; 2Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. 780.Efficient In Vivo T2 Mapping by Prior-information-driven SLIM-BLAST Reconstruction Jeffrey Tsao1, Victor D. Schepkin1, Paul C. Lauterbur1 1University of Illinois at Urbana-Champaign, Urbana, IL, USA. 781.MR Image Reconstruction from Novel 3D Radial Sampling Distributions Ralf Lethmate1, J.A.C. Van Osch2, Frank Wajer2, Dirk Van Ormondt2, Danielle Graveron-Demilly1 1Université Claude Bernard, Villeurbanne, France; 2Delft University of Technology, Delft, The Netherlands. 782.Non-Orthogonal Non-Fourier Spatial Encoding for Dynamic MRI Gary P. Zientara1, Arjun V. Masurkar2, Dimitrios Mitsouras2, Lawrence P. Panych1, Ferenc A. Jolesz1 1Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA; 2Massachusetts Institute of Technology, Cambridge, MA, USA. 783.NoQuist: Reduction of Spatial Sampling Rate In Dynamic MR Imaging Marijn Brummer1, W. Thomas Dixon2, Chung-Yi Hong1, Roderic Pettigrew1 1Emory University, School of Medicine, Atlanta, GA, USA; 2General Electric Corporate R&D, Niskayuna, NY, USA. 784.Partial Fourier Imaging in Multi-Dimensions: A Means to Save a Full Factor of Two in Time Yingbiao Xu1, E. Mark Haacke1 1The MRI Institute for Biomedical Research, St. Louis, MO, USA. 785.A Novel Method to Obtain Spatially Localized Point-Spread-Functions in Phase Encoded Imaging. Lawrence Patrick Panych1, Lei Zhao2 1Harvard University, Harvard Medical School, Boston, MA, USA; 2Harvard University, Brigham & Women's Hospital, Boston, MA, USA. 786.A Variable Resolution Reconstruction Technique Eugene G Kholmovski1, Dennis Lee Parker1, Andrew Alexander1 1University of Utah, Salt Lake City, UT, USA. 787.A Least Squares Approach to Half-Fourier Imaging for fMRI Xiaodong Zhang1, Essa Yacoub1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 788.Localization of Active MR Devices: A Comparison between Different Postprocessing Methods Michael Bock1, Steffen Volz1, Hans-Joachim Zabel1, Reiner Umathum1, Wolfhard Semmler1 1Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. 789.Improved Single Point Water-Fat Imaging with Virtual Shimming Qing-San Xiang1 1University of British Columbia, BC Children's Hospital & St. Paul's Hospital, Vancouver, BC, Canada. Various Image Processing and Display Techniques Hall 4 Wednesday: 13:30 - 15:30 790.Generalized Line Integral Convolution Rendering of Diffusion Tensor Fields Edward Hsu1 1Duke University, Durham, NC, USA. 791.An Algorithm for Preservation of Orientation during Non-Rigid Warps of Diffusion Tensor Magnetic Resonance (DT-MR) Images Daniel Alexander1, Carlo Pierpaoli2, Peter Basser2, James C. Gee3 1University College London, London, UK; 2National Institutes of Health, Bethesda, MD, USA; 3University of Pennsylvania, School of Medicine, Philadelphia, PA, USA. 792.Anisotropic Diffusion Method for Denoising Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Images Kenya Murase1, Takayuki Kitada1, Youichi Yamazaki1, Shin-Ichiro Iwamoto1, Yoshihiro Ueno1, Keiichi Kikuchi2, Hitoshi Miki2, Junpei Ikezoe2 1Osaka University Medical School, Suita, Osaka Japan; 2Ehime University School of Medicine, Ehime, Japan. 793.Techniques For The Deformation Morphology Of MRI Data Using Modifications Of The Kohonen Network Model Simon J. P. Meara1, John Suckling2, Steven C. R. Williams1, Tonmoy Sharma1 1Institute of Psychiatry, London, UK; 2Guy's, King's and St. Thomas' School of Medicine, London, UK. 794.An MLE Based Segmentation Method for Quantitation in MR Images R.K.S. Rathore1, Sushmita Datta1, R.K. Gupta2, S.B. Rao1, R. Verma2 1Indian Institute of Technology Kanpur, Kanpur India; 2SGPGIMS, Lucknow, India. 795.Lesion Size Estimation Using Warped Registration of Interval Images John B. Weaver1, Senthil Periaswamy2, Hany Farid2, Daniel N. Rockmore2, Claudia J. Kasales1, William Black1, D. M. Healy, Jr.2 1Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA; 2Dartmouth College, Hanover, NH, USA. 796.Tissue Volume Estimation of an Object Based on Polygonal Model Chao Han1, Shaoxiong Zhang1, Thomas S. Hatsukami2, Chun Yuan1 1University of Washington, School of Medicine, Seattle, WA, USA; 2University of Washington School of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. 797.Quantitative Mapping of Magnetic Fluid Distributions by Means of MR Susceptometry Koshan Mahdi1, Waldemar Wlodarczyk, Thomas Lange1, Regina Scholz, Andreas Jordan, Peter Wust 1Humboldt-Universitat zu Berlin, Berlin, Germany. 798.NMRj: A Feasability Study for a Fully Java Based Platform Independent MR Processing and Analysing Program Torsten Schlumm1, Thomas Riemer1 1Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Leipzig, Leipzig, Germany. Image Processing: Coil Sensitivity Maps Hall 4 Wednesday: 13:30 - 15:30 799.Robust Estimation of Coil Sensitivities for RF Subencoding Acquisition Techniques Miguel Angel Gonzalez Ballester1, Yoshio Machida1, Yoshimori Kassai1, Yoshinori Hamamura1, Hiroshi Sugimoto1 1Medical Systems R&D Center, Toshiba, Otawara, Tochigi, Japan. 800.Variational Based Coil Sensitivity Estimation S.L. Keeling1, R. Bammer1 1University of Graz, Graz, Austria. 801.Estimation of Coil Sensitivity Map and Correction of Surface Coil Magnetic Resonance Images using Wavelet Decomposition Fa-Hsuan Lin1, Lawrence L. Wald2, Ying-Jui Chen3, John W. Belliveau2 1Havard-MIT Division of Health Sciences and Technology, Massachusetts General, Charlestown, MA, USA; 2Massachusetts General Hospital, Charlestown, MA, USA; 3Boston University, Boston, MA, USA. 802.Phased-Array Coil SNR Maps using Sensitivity Analysis C. Celil Guclu1 1GE Medical Systems, Milwaukee, WI, USA. Image Processing: Brain and Spine Hall 4 Wednesday: 13:30 - 15:30 803.3D Neuroantomical Segmentation of MR Brain Images Choong Leong Tan1, Jagath Rajapakse1 1Nanyang Technological University, Singapore. 804.Hybrid Atlas-Based and Image-Based Approach for the Automatic Segmentation of Brain Structures. Olivier Musse1, Gloria Bueno2, Fabrice Heitz2, Jean-Paul Armspach1, Izzie Namer1, Daniel Grucker1 1Institut Physique Biologique, Strasbourg, France; 2LSIIT ULP, Strasbourg, France. 805.Effect of Gain Field Inhomogeneity Correction on Automated Segmentation of the Intracranial Cavity Ying Wu1, William M. Wells III1, Simon K Warfield1, Xingchang Wei1, Xiaoming Li1, Mark Anderson1, Charles R.G. Guttmann1 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 806.Unsupervised Statistical Segmentation and Stereological Validation of 3D T1/T2 Brain Tissue Grey and White Matter Volumes Using Mahalanobis Distance Method Calvin Hisley1, Katrina Read1, Rao P Gullapalli1 1University of Maryland, Baltimore, Baltimore, MD, USA. 807.Application of Independent Component Analysis for Better Segmentation of Gray and White Matters Toshiharu Nakai1, Shigeru Muraki2, Haruo Isoda3, Yasuo Takehara3, Harumi Sakahara3, Kayako Matsuo1, Chikako Kato4, Yukio Miki5 1AIST / Kobe AMC, Ikeda, Osaka Japan; 2AIST, MITI, Tsukuba, Ibaragi Japan; 3Hamamatsu University School of Medicine, Hamamatsu, Japan; 4Toyohashi Sozo College, Toyohashi, Japan; 5Kyoto University Hospital, Sakyo-ku, Kyoto, Japan. 808.Segmentation of Brain Tumor Boundaries using Pattern Recognition of Magnetic Resonance Spectroscopy Donald J. Peck1, David O. Hearshen1, Lisa Scarpace1, Hamid Soltanian-Zadeh1, Tom Mikkelsen1 1Henry Ford Hospital, Detroit, MI, USA. 809.Comparison of Quadratic and Linear Discriminate Analyses in the Self-Adaptive Feature Vector Quantization Scheme for MR Image Segmentation Lihong Li1, Dongqing Chen1, Hongbing Lu1, Zhengrong Liang1 1State University of New York at Stony Brook, Stony Brook, NY, USA. 810.An Automated Registration Algorithm for Measuring Relative Rotation of Vertebrae in Spinal MR Images Baxter Rogers1, Victor Haughton1, M. Meyerand1 1University of Wisconsin-Madison, Madison, WI, USA. 811.Intra-Subject Slice-to-Volume Registration of MR Images Tae-Seong Kim1, Sungheon Kim1, Nilesh Ghugre1, Jeong Won Jeong1, Manbir Singh1 1University of Southern California, Los Angeles, CA, USA. 812.Evaluation of Brain Atrophy Measurements from Multiple Scanners Elizabeth Fisher1, Karla Dixon1, Daniel Finelli1, Jean Tkach1, Frank Difilippo1 1Cleveland Clinic Foundation, Cleveland, OH, USA. 813.Volume Measurements of the Caudate Nucleus using High-Resolution 3D Magnetic Resonance Imaging Kilichan Gurleyik1, Yingbiao Xu2, E. Mark Haacke2 1Washington University, The MRI Institute for Biomedical Research, Brentwood, MO, USA; 2The MRI Institute for Biomedical Research, St. Louis, MO, USA. 814.Registration of Postmortem Brain Slices to Matching MR Slices within 3D Reference MRI Tae-Seong Kim1, Manbir Singh1, Nilesh Ghugre1, Sungheon Kim1, Chris Zarow1, Helena Chui1 1University of Southern California, Los Angeles, CA, USA. 815.Estimation of Multiple Sclerosis Lesions´ 3-D Geometry by Spherical Harmonics Daniel Goldberg-Zimring1, Anat Achiron2, Shmuel Miron2, Haim Azhari1 1Technion- Israel Institute of Technology, Technion City, Haifa Israel; 2Sheba Medical Center, Tel Hashomer, Israel. 816.Brain Volumes From 3D Volumetric MRI Images Charles Dennis Smith1, Anders Andersen1 1University of Kentucky, Medicine, Lexington, KY, USA. 817.Reduction of the Brain Tissue Volume in Alzheimer Disease. Clinical study vs Quantitative Measurements Krzysztof Szybinski1, Andrzej Urbanik2, Rafal Motyl2, Andrzej Szczudlik2, Justyna Kozub2, Barbara Sobiecka2, Andrzej Jasinski1 1H. Niewodniczanski Institute of Nuclear Physics, Krakow, Poland; 2Jagiellonian University, Krakow, Poland. 818.Building Whole Brain Maps of Atrophy Rate from Multi-Subject Longitudinal Studies Using Free Form Deformations. Colin Studholme1, Valerie A Cardenas-Nicolson1, Michael Weiner1 1University of California, San Francisco, San Francisco, CA, USA. 819.Quantification of Spinal Cord Atrophy via an Active Surface Model Olivier Coulon1, Geoffrey J.M. Parker2, Simon J. Hickman2, Simon R. Arridge1 1University College London, London, England, UK; 2Institute of Neurology, London, England, UK. 820.Validation of Anisotropic Filtering for Myelin Water Maps Craig Jones1, Kenneth Whittall1, Alex MacKay1 1University of British Columbia, Vancouver, BC, Canada. 821.An Alternative Approach to Visualizing m-Dimensional MRI Data Sean Deoni1, Brian K. Rutt1, Terry M. Peters1 1The John P. Robarts Research Institute, London, Ontario, Canada. 822.Definition of the Neurochemical Patterns of Human Head Injury in 1H MRS Using Wavelet Analysis Frederick Shic1, Alexander Lin1, C Hunter Shelden1, Nick Panagiotacopulos2, Brian Ross1 1Huntington Medical Research Institutes, Pasadena, CA, USA; 2California State University, Long Beach, CA, USA. 823.Hippocampal Sclerosis in Mesial Temporal Lobe Epilepsy Characterised by MRI-Texture Analysis; Clinical Interest Olivier Yu1, Yves Mauss1, Izzie Namer1, Jacques Chambron1 1Université Louis Pasteur de Strasbourg, Faculté de Médecine, Strasbourg, France. Image Processing: Cardiac and Vascular Hall 4 Wednesday: 13:30 - 15:30 824.An Automatic Method to Measure Vessel Wall Thickness Based on Black Blood MRI Xiaojian Kang1, Dongxiang Xu2, Chun Yuan2 1University of California at Davis, School of Medicine, Martinez, CA, USA; 2University of Washington, Seattle, WA, USA. 825.Automatic Perfusion Analysis Tool from Contrast Enhanced Cardiac MRI Maria Filomena Santarelli1, Vincenzo Positano1, Franco Gianvanni2, Luigi Landini2, Massimo Lombardi1, Antonio L' Abbate1, Antonio Benassi1 1Institute of Clinical Physiology, Pisa, Italy; 2Dept. of Information Engineering, Pisa, Italy. 826.Fast LV Segmentation in Single Slices Krishna Nayak1, Shin-Ichi Urayama2, Craig Meyer1 1Stanford University, Stanford, CA, USA; 2National Cardiovascular Center, Osaka, Japan. 827.Automated Segmentation of Cardiac Magnetic Resonance Images M. B. Stegmann1, J. C. Nilsson2, B. A. Grønning2 1Technical University of Denmark, Lyngby, Denmark; 2H:S Hvidovre Hospital, Hvidovre, Denmark. 828.Mapping Left Ventricle Wall Motion and Strain from MR Tagging Images. Application on Left Bundle Branch Block Patients. Annette Van Der Toorn1, Gabriel Snoep1, Petra Van Pol1, Frits W. Prinzen1, Theo Arts1 1Maastricht University, Maastricht, Netherlands. 829.Synthetic Tagged MR Images For Real-time HARP Imaging Nael F Osman1, Smita Sampath1, J. Andrew Derbyshire2, Ergin Atalar1, Jerry Ladd Prince1 1Johns Hopkins University, Baltimore, MD, USA; 2GE Medical Systems, Milwaukee, WI, USA. 830.Automatic, Accurate, Real-time Processing of SPAMM-tagged Myocardium Images Cyril Allouche1 1Philips Research France, Limeil-Brevannes, France. 831.Computation and Visualization of 3D Tag Intersections from a 4D B-Spline Model of Tagged MRI J. Huang1, Amir A. Amini1 1Washington University, St. Louis, MO, USA. 832.A Novel Segmentation Technique For Quantitative Evaluation of Atherosclerotic Plaque Tissues Using MR Images with Multiple Contrast Weighting Dong Xiang Xu1 1Seattle, WA, USA. 833.Quantitative Tissue Characterization of Atheroslerotic Plaques by Magnetic Resonance: Comparison Between Ex Vivo and Histological Findings Maria Filomena Santarelli1, Alessandro Pingitore1, Mirko Cosottini2, Vincenzo Positano1, Angelo Bonadio2, Luigi Landini3, Massimo Lombardi1, Antonio L'Abbate1, Antonio Benassi1 1Institute of Clinical Physiology, Pisa, Italy; 2Pisa University, Pisa, Italy; 3Dept. of Information Engineering, Pisa, Italy. 834.Detecting Objects In MR Image Sequences Based On Minimal Path Active Contour Model Chao Han1, Williams S Kerwin1, Thomas S. Hatsukami2, Jeng Neng Hwang1, Chun Yuan1 1University of Washington, Seattle, WA, USA; 2University of Washington, School of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA. USA. 835.Automated Analysis of Cine Phase Contrast Velocity Images using Score Guided Erosion Martin J Graves1, Mark P Brewin1, Andrew N Priest1, Richard A R Coulden1 1University of Cambridge, Addenbrooke's Hospital, Cambridge, England, UK. 836.A New Automatic Method for Producing Venograms From Pre and Post Gadolinium Enhanced 3D Data David Brennan1, Barrie Condon1, Donald Hadley1 1Southern General Hospital, Glasgow, Scotland, UK. Image Processing: Body Hall 4 Wednesday: 13:30 - 15:30 837.3D Finite Element Model for Breast MRI Non-rigid Registration Abbas Samani1, Jonathan Bishop1, Donald Plewes1 1University of Toronto, Toronto, ON, Canada. 838.3-D Topographic Characterization of Breast Lesions based on Contrast Enhanced MR Images Meiyappan Solaiyappan1, Karen H. Shahar1, David A. Bluemke1 1Johns Hopkins University, Baltimore, MD, USA. 839.An Artificial Neural Network for the Segmentation of Dynamic MR Mammographic Image Series Robert E.A. Lucht1, Stefan Delorme2, Gunnar Brix1 1Bundesamt fuer Strahlenschutz, Oberschleissheim, Germany; 2Deutsches Krebsforschungszentrum, Heidelberg, Germany. 840.Automated Nasopharyngeal Carcinoma Detection with Pharmacokinetic Dynamic Gadolinium-Enhanced MR Imaging Ping H. Lai1, Cheng C Hsu2, Chung N Lee, Wei L Chen, Huay B Pan, Chien F Yang 1Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan; 2National Sun Yat-Sen University. 841.Validation of a Registration Algorithm for Serial 3D MR Data Sets Jürgen R. Reichenbach1, Jens Hopfe2, Matthias E. Bellemann2, Werner A. Kaiser1 1Friedrich-Schiller-Universität Jena, Jena, Germany; 2University of Applied Sciences, Jena, Germany. 842.Border and Texture Descriptors for Breast MRI Lesions R. Sivaramakrishna1, N. Obuchowski1, S. A. Englander2, M. Schnall2 1Cleveland Clinic Foundation, Cleveland, OH, USA; 2University of Pennsylvania, Philadelphia, PA, USA. 843.Modeling Liver Motion and Deformation During the Respiratory Cycle Using Intensity-Based Free-Form Registration of Gated MR Images Torsten Rohlfing1, Walter O'Dell1, Calvin R Maurer Jr1, Jianhui Zhong1 1University of Rochester, Rochester, NY, USA. 844.A Fast Method for Estimating Voxel Bone Volume Fractions from In Vivo High-Resolution MR Images Scott Nyshin Hwang1, Felix W. Wehrli1 1University of Pennsylvania Medical Center, Philadelphia, PA, USA. 845.Integrated Processing System for In Vivo MR Images of Trabecular Bone Networks Bryon Gomberg1, Punam Saha1, Scott N. Hwang1, Hee Kwon Song1, Felix Wehrli1 1University of Pennsylvania, Philadelphia, PA, USA. 846.A Numerical Model for the Quantitation of High-Resolution Skin Images at 2.0 T with Application to the Effects of Hydration Karen Gannon1, Matthew Clemence1, Ian Robert Summers1, Nigel Davies1, Gill Miller2 1University of Exeter, Exeter, Devon, UK; 2Royal Devon and Exeter Hospital, Exeter, Devon, UK. 847.In Vivo Measurement of Changes in Cartilage Lesions from MRI of the Knee using Image Registration and Semi-Automated Image Analysis. John A Lynch1, Souhil Zaim1, Jenny Zhao1, Charles G Peterfy1, Harry K Genant1 1University of California at San Francisco, San Francisco, CA, USA. 848.Quantification of Bone Lesion Changes in Rheumatoid Arthritis by Temporal Multispectral Analysis Richard A. D. Carano1, John A. Lynch2, Yves Miaux1, Souhil Zaim2, Harry K. Genant2 1Synarc Inc., San Francisco, CA, USA; 2University of California, San Francisco, CA, USA. 849.Segmentation of Muscle and Fat Compartments from MR Images using a Fuzzy Clustering Algorithm Vincent Barra1, Boire Jean-Yves1 1ERIM - Faculty of Medicine, Clermont Ferrand, France. Contrast Mechanisms Hall 4 Thursday: 13:30 - 15:30 850.Enhanced Sensitivity to Molecular Diffusion with Intermolecular Multiple-Quantum Coherences (iMQCs) and its Potential Applications Jianhui Zhong1, Wing-Chi Edmund Kwok, Zhong Chen, Scott Kennedy1 1University of Rochester, Rochester, NY, USA. 851.Quantitative Investigation of Optimized RF Flip Angles for Different Intermolecular Multiple-Quantum Coherences Zhiwei Chen1, Shaokuan Zheng, Zhong Chen, Jianhui Zhong2 1Xiamen University, Xiamen, Fujian, P. R. China; 2University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA. 852.Quantitation of Transverse Relaxation Time of Intermolecular Multiple-Quantum Coherences Zhong Chen1, Shaokuan Zheng2, Zhiwei Chen2, Jianhui Zhong1 1University of Rochester, Rochester, NY, USA; 2Xiamen University, Xiamen, Fujian, China. 853.SNR Potential of Intermolecular Double-Quantum Coherence Imaging at High Magnetic Fields Edward J. Auerbach1, Jianhui Zhong2, Edmund Kwok2, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA; 2University of Rochester, University of Rochester Medical Center, Rochester, NY, USA. 854.Effects of Proton Exchange and Cross-Relaxation on the On-Resonance T1rð Relaxation in the Protein Phantoms: Search for the Mechanism of T1rð Contrast in Tissue Heidi Mäkelä1, Olli Gröhn1, Mikko Kettunen1, Risto Kauppinen1 1University of Kuopio, Kuopio, Finland. 855.Vascular Imaging Using T1rho Weighting and Spin-Lock Labeling Haim Azhari1, Charles A McKenzie2, Robert R. Edelman2 1Technion- Israel Institute of Technology, Technion City, Haifa Israel; 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 856.Examination of Susceptibility Effects by Spin-Locking Technique Petros Martirosian1, Michael Deimling2, Axel Haase3 1University of Tübingen, Tübingen, Germany; 2Siemens Medical Systems, Erlangen, Germany; 3Insitute of Physics, Würzburg, Germany. 857.True Carr-Purcell Imaging for High Resolution and Novel Contrast Robert Bartha1, Shalom Michaeli1, Hellmut Merkle1, Gregor Adriany1, Peter Andersen1, Wei Chen1, Kamil Ugurbil1, Michael Garwood1 1The University of Minnesota, Minneapolis, MN, USA. 858.Protein Mediated MT of Small Molecules Scott D. Swanson1 1University of Michigan, Medical School, Ann Arbor, MI, USA. 859.Serial Investigation of Magnetization Transfer in New Multiple Sclerosis Lesions Cornelia Laule1, Irene Vavasour1, Alex MacKay1, Kenneth Whittall1, DKB Li1, DW Paty1 1University of British Columbia, Vancouver, BC, Canada. 860.Histogram Analysis of Magnetization Transfer Measurements Reveals Calf-Muscle Abnormalities in Venous Leg Ulcer Patients Nigel Davies1, Alan Bainbridge1, Matthew Clemence1, William Vennart2 1University of Exeter, Exeter, UK; 2Pfizer Central Research, Sandwich, UK. 861.Rapid Quantitation of Magnetisation Transfer Using Echo Planar Imaging Damian Tyler1, Penny Gowland1 1University of Nottingham, Nottingham, England, UK. 862.SIR-PGSE: a Two-Dimensional MT-Diffusion Pulse Sequence Daniel F. Gochberg1, John C. Gore1 1Yale University, New Haven, CT, USA. 863.Impact of Tensile Load on Rabbit Achilles Tendon Characterized by MRI Spatial Differentiation of T1, T2 and ADC Parameters Jeremy Wellen1, Karl Helmer2, Peter Grigg3, Christopher Sotak2 1Worcester Polytechnic Institute, University of Massachusetts Medical School, Worcester, MA, USA; 2Worcester Polytechnic Institute, Worcester, MA, USA; 3University of Massachusetts Medical School (Worcester), Worcester, MA, USA. 864.Multi-Inversion Technique For Robust T1 Suppression in Conjunction with Blood-Labeled Inflow Puneet Sharma1, W. Thomas Dixon2, John Oshinski2 1Georgia Institute of Technology, Atlanta, GA, USA; 2Emory University, Atlanta, GA, USA. 865.Magnetization Driven Preparation Scheme for Selective Enhancement of Short T1 Species Suitable for Fast Imaging of Contrast Enhanced Tissue. Yun Gao1, Erbil Akbudak1, Nikolaos V. Tsekos1 1Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA. 866.A Quantitative Model for Brain Iron Imaging Using R2 Jim M. Wild1, W. R. Wayne Martin2, Peter S. Allen2 1University of Alberta, Sheffield, England, UK; 2University of Alberta, Edmonton, Alberta, Canada. 867.Analysis of Echoes in Missing Pulse Steady State Free Precesssion by Phase Encoding Separation Ken-Pin Hwang1, Jeffrey L. Duerk1 1Case Western Reserve University / University Hospitals of Cleveland, Cleveland, OH, USA. 868.Water T1( Dispersion is Influenced by Amide Protons at Physiologic pH A. Goldberg1, U. Duvvuri1, L. Hoang1, S. W. Englander1, Felix Wehrli1, R. Reddy1, J. S. Leigh1 1University of Pennsylvania, Philadelphia, PA, USA. New Contrast Agents and Applications Hall 4 Thursday: 13:30 - 15:30 869.Development of a New MRI Contrast Agent for the Targeting of the Endothelial Leukocyte Adhesion Molecule ELAM-1 Jean-Marie Colet1, Sophie Laurent1, Y. Fu1, Robert Muller1 1University of Mons-Hainaut, Mons, Belgium. 870.Paramagnetic PLGA Microspheres for the Monitoring of Drug Delivery with MRI Anthony Z. Faranesh1, Cristina Perez de la Cruz1, Michael F. Haller1, Kam W. Leong1, Elliot R. McVeigh2 1The Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2National Institutes of Health, Bethesda, MD, USA. 871.Detection of Cationic-Polymer-Based Gene Delivery Systems Without Paramagnetic Metals Nick Goffeney1, Jeff Bulte2, Jeff Duyn2, L. H. Bryant Jr.2, Peter C. Van Zijl1 1Johns Hopkins University, Baltimore, MD, USA; 2National Institutes of Health, Bethesda, MD, USA. 872.USPIO-Enhanced Dynamic MRI: Evaluation of Normal and Transplanted Rat Kidneys Dewen Yang1, Qing Ye1, Tom Hu1, Mangay Williams1, Donald Williams1, Chien Ho1 1Carnegie Mellon University, Pittsburgh, PA, USA. 873.Detection and Grading of Acute Transplant Rejection with Magnetic Resonance Imaging using a Blood Pool Contrast Agent in the Rat Eva Penno1, Lars Johansson1, Atle Bjornerud2, Cecilia Johnsson1, Hakan Ahlstrom1 1Uppsala University Hospital, Uppsala, Sweden; 2Nycomed Imaging AS, Oslo, Norway. 874.Contrast-Enhanced High Resolution MRI of Atherosclerotic Plaque in Watanabe Rabbits Linda Chaabane1, Philippe Douek2, Francis Contard3, Claire Corot4, Daniel Guerrier3, André Briguet1, Emmanuelle Canet2 1Université Lyon 1, Villeurbanne, France; 2Hôpital Cardiologique, Lyon, France; 3Lipha SA, Lyon, France; 4Laboratoire Guerbet, Paris, France. 875.Influence of Tangential Plasma Flow on Fibrinolysis of Non-occlusive Thrombi: Study by MR Microscopy Igor Sersa1, Mitja Strukelj2, Ales Blinc2 1Jozef Stefan Institute, Ljubljana, Slovenia; 2University of Ljubljana Medical Center, Ljubljana, Slovenia. 876.T1-weighted Dynamic MRI for Blood Volume Quantification in Rat Liver Tumors Using Sinerem and Resovist Christiane Poeckler-Schoeniger1, Julian Koepke1, Olaf Gunnar Schueler2, Wolfgang Guenther Schreiber3, Peter Bannasch4, Christoph Dueber1 1Klinikum Mannheim gGmbH, Mannheim, Germany; 2University of Heidelberg, Munich, Bavaria, Germany; 3Johannes Gutenberg-University, Mainz, Germany; 4German Cancer Research Center Heidelberg, Heidelberg, Germany. 877.High Field Trasverse Relaxivity of Dy-complexes: An Example of Limited Transverse Relaxivity by the Water Exchange Rate Luce L. Vander Elst1, Shanrong Zhang2, A. Sherry2, Robert Muller1 1University of Mons-Hainaut, Mons, Hainaut Belgium; 2University of Texas at Dallas, TX, USA. 878.The Use of Starburst Dendrimers as pH Contrast Agents Peter C. Van Zijl1, Nick Goffeney1, Jeff Duyn2, L. H. Bryant Jr.2, Jeff Bulte2 1Johns Hopkins University, Baltimore, MD, USA; 2National Institutes of Health, Bethesda, MD, USA, 879.Tissue Distribution of 153Gd-Labeled Gadoversetamide in Mice Paul Wedeking1, S. Eaton1, Karen E. Linder1, J. Johnstone1, Michael F. Tweedle1 1Bracco Research USA, Princeton, NJ, USA. 880.Quantitative Analysis of SPIO and USPIO Uptake Rate by Macrophages: Effects of Particle Size, Concentration, and Labeling Time Xiaowei Zhang1, Chris V. Bowen1, Paula Gareau1, Brian K. Rutt1 1The John P. Robarts Research Institute, London, Ontario, Canada. 881.Synthesis and Relaxometric Analysis of P760, a New Macromolecular Contrast Agent with High Relaxivity and Particular Pharmacokinetic Properties. Marc Port1, Isabelle Raynal, Luce L. Vander Elst2, Olivier Rousseaux, Christian Simonot, Alexandra Metois, Robert Muller2 1Guerbet, Roissy, France; 2University of Mons-Hainaut, Mons, Belgium. 882.Synthesis, Kinetic Stability, Relaxometry and X-ray Crystal Structures of Cu(II), Mn(II), and Gd(III) 18-Membered Hexaazamacrocyclic Complexes as Potential MR Contrast Agents L. Henry Bryant, Jr.1, E. Dadachova1, Martin W. Brechbiel1, Joseph Frank1 1National Institutes of Health, Bethesda, MD, USA. 883.Synthesis, Thermodynamic, Water-exchange, Electronic Relaxation and Relaxivity Studies for the Complexation of Gd3+ by TTDA, TTDA-PY, TTDA-HP, TTDA-H1P and TTDA-H2P as Contrast Agents for MRI Yun-Ming Wang1, Tsann Hwang Cheng Stude1, Gin Chung Liu1, Reu Sheng Sheu1, Twei Shiun Jaw1 1Kaohsiung Medical University, Kaohsiung, Taiwan. 884.Novel Intravascular Macromolecular MR Contrast Agents with Generation-4 Polyamidoamine Dendrimer Core: Accelerated Renal Excretion of with Co-Injection of Lysine Noriko Sato1, Hisataka Kobayashi1, Satomi Kawamoto2, Tsuneo Saga1, Akira Hiraga3, Takayoshi Ishimori1, Kaori Togashi1, Junji Konishi1, Martin W Brechbiel4 1Kyoto University Graduate School of Medicine, Kyoto, Japan; 2Otsu Municipal Hospital, Otsu, Shiga Japan; 3Kyoto University Hospital, Kyoto Japan; 4National Institutes of Health, Bethesda, MD, USA. 885.Positive Effects of Polyethylene Glycol Conjugation to Generation-4 Polyamidoamine Dendrimers Employed as Macromolecular MR Contrast Agents Hisataka Kobayashi1, Satomi Kawamoto2, Tsuneo Saga1, Noriko Sato1, Akira Hiraga3, Takayoshi Ishimori1, Tabassum Laz Haque1, Junji Konishi1, Kaori Togashi1, Martin W. Brechbiel4 1Kyoto University, Graduate School of Medicine, Kyoto, Japan; 2Otsu Municipal Hospital, Otsu, Shiga Japan; 3Kyoto University Hospital, Kyoto Japan; 4National Institutes of Health, Bethesda, MD, USA. 886.Enumeration of Diamagnetic and Paramagnetic Liposomes by Multinuclear NMR and Photon Correlation Spectroscopy Luce L. Vander Elst1, C. Piérart1, S. Fossheim2, J. C. Raux1, A. Roch1, Robert Muller1 1University of Mons-Hainaut, Mons, Hainaut, Belgium; 2School of Pharmacy, Oslo, Norway. 887.Comparison of Vascular Permeability Between Ischemic Tissue and Tissue Over Expressing VEGF Using High Relaxivity Polymerized Vesicles as MR Contrast Agents Samira Guccione1, Yi-Shan Yang1, Matthew L. Springer1, Helen M. Blau1, King C. Li1, Mark Bednarski1 1Stanford University, Stanford, CA, USA. 888.Safety Assessment of Gadobenate Dimeglumine (MultiHance®): Extended Clinical Experience from Phase II Studies to Post-Marketing Surveillance Miles Andrew Kirchin1, Pirovano Gianpaolo2 1Medical & Regulatory Affairs, Milan, Italy; 2Bracco Diagnostics Inc., Princeton, NJ, USA. 889.Approval Status of MR Contrast Media World-Wide Val M. Runge1, Michael V. Knopp2 1University of Kentucky, Lexington, KY, USA; 2The German Cancer Research Center (dkfz), Heidelberg, Germany. Relaxometry and Applications Hall 4 Thursday: 13:30 - 15:30 890.Measurements of the Relaxivity of Gadolinium Chelates in Tissues In Vivo Dilin Xie1, Richard P Kennan2, John C. Gore2 1Medical Science Research Institute of Fujian Province, Fuzhou, Peoples Republic of China; 2Yale University School of Medicine, New Haven, CT, USA. 891.Theory of MR Relaxation Caused by Mesoscopic Impurities: A Possibility to Monitor the Red Blood Cell Shape Valerij G. Kiselev1, Dmitry S. Novikov2 1Freiburg University Hospital, Freiburg, Germany; 2Massachusetts Institute of Technology, Cambridge, MA, USA. 892.T2 Relaxation of Muscle In Vivo After Saline Injection Giulio Gambarota1, Brian E Cairns2, Charles B Berde2, Robert V Mulkern2 1Boston College, Children's Hospital, Boston, MA, USA; 2Children’s Hospital, Boston, MA, USA. 893.MRI Based Observations of Osmotic Response Within In Vivo Muscle Giulio Gambarota1, Brian E Cairns2, Charles B Berde2, Robert V Mulkern2 1Boston College, Children's Hospital, Boston, MA, USA; 2Chileren’s Hospital, Boston, MA, USA. 894.The Effect of Glycogen Storage Diseases on Multi-Component T2 Relaxation of In Vivo Skeletal Muscle Chris Devine1, George Saab1, Paul A. Picot1, Tim Doherty2, Mark Tarnopolsky2, R. Terry Thompson1 1Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada; 2McMaster University Medical Centre, McMaster University, Hamilton, Ontario, Canada. 895.Multi-component Transverse Relaxtion of Nerve at 11.7 and 18.8 Tesla Keith Wachowicz1, Stephane Gagne1, Richard E. Snyder1, Brian D. Sykes1, Christian Beaulieu1 1University of Alberta, Edmonton, AB, Canada. 896.Shortening the Acquisition Time of a 48 Echo T2 Relaxation Pulse Sequence by Varying TR Across K-Space Cornelia Laule1, Kenneth Whittall1, Alex MacKay1 1University of British Columbia, Vancouver, British Columbia, Canada. 897.Fast Multi-Slice T1 Mapping Using Multiple Echoes Maxim Zaitsev1, Sven Steinhoff1, Karl Zilles1, N. Jon Shah1 1Institute of Medicine, Research Centre Jülich, Jülich, Germany; 898.Rapid 3D T1 Mapping Paul S. Morgan1, Alan R Moody1, Chris R Tench1, Lalitha Vaithianathar1 1University of Nottingham, University Hospital, Nottingham, England, UK. 899.Increasing the Repetition Time TR Does Not Necessarily Improve the Precision of Inversion-Recovery T1 Measurements Peter B. Kingsley1, W. Gordon Monahan1 1North Shore University Hospital, Manhasset, NY, USA, and New York University School of Medicine, New York, NY, USA. 900.A Novel Method To Measure Emulsification L Marciani1, C Ramanathan1, D Tyler1, P Manoj2, P Young1, M Wickham2, A Fillery-Travis2, R Spiller3, P Gowland1 1Nottingham University, Nottingham, UK; 2Institute of Food Research, Norwich, UK; 3Queen’s Medical Centre, Nottingham, UK. 901.Radiation Dosimetry using MRI of Normoxic Polymer Gels Peter M. Fong1, Derek C. Keil2, John C. Gore1 1Yale University, School of Medicine, New Haven, CT, USA; 2Yale College, New Haven, CT, USA. 902.Verification of Stereotactic Radiosurgery Procedure with the Use of 3D Polymer Gel Dosimeter Evaluated by NMR Josef Novotny Jr.1, Josef Vymazal1, Pavel Dvorak2, Vaclav Spevacek2, Jaroslav Tintera3, Josef Novotny1, Tomas Cechak2 1Hospital Na Homolce, Prague, Czech Republic; 2Technical University of Prague, Prague, Czech Republic; 3University of Mainz, Mainz, Germany. 903.MRI and MRS of Radiation Distributions using a Polymer-Gel Dosimeter Gary Paul Liney1, David John Manton2, James Hutton1, Andy Beavis1, Lindsay W Turnbull2 1Hull & East Yorkshire NHS Trust, Hull Royal Infirmary, Hull, England, UK; 2University of Hull, Hull, England, UK. Other MRI Sequences Hall 4 Thursday: 13:30 - 15:30 904.Effect of Variable Echo Spacing in Multi-Echo Sequences for Resolving Long T2 Components in Multiple Sclerosis p Matthew Skinner1, Kenneth Whittall1, Alex MacKay1 1University of British Columbia, Vancouver, British Columbia, Canada. 905.Detection of Tissue Oxygen Changes using Interleaved T2 and T2* Non-CPMG SSFSE Imaging Pierre Carlier1, Anne Darquie2, Vincent Lebon3, A. Andrade2, R.J. Gilles2, P. Le Roux4 1Jemeppe-Sur-Sambre, Belgium; 2CEA-SHFJ, Orsay, France; 3Yale University, School of Medicine, New Haven, CT, USA; 4GE Medical Systems, Buc, France. 906.Mixed-Bandwidth Acquisitions: SNR and Noise Texture Peter Jakob1, Ralf Löffler2, Claudia Hillenbrand1, Axel Haase1, P. Kreisler2 1University of Wurzburg, Wurzburg, Germany; 2Siemens Medical Systems, Erlangen, Germany. 907.Multiple Spin Echoes as a Tool to Probe Microstructures: Application on Phantoms Francesco Maria Alessandri1, Silvia Capuani1, Bruno Maraviglia1, Angelo Bifone2 1Istituto Nazionale Fisica della Materia (INFM), University La Sapienza, Rome, Italy; 2The Institute of Cancer Research, Sutton, Surrey,UK. 908.Choosing the Best Arterial Spin Labeling Perfusion Sequence: FAIR vs. FAIRER vs. EST Shella D Keilholz-George1, Stuart Scott Berr1 1University of Virginia, School of Medicine, Charlottesville, VA, USA. 909.A New Method for Obtaining Quantitative ASL Perfusion Maps: A Comparison with the FAIR Method Shella D Keilholz-George1, Stuart Scott Berr1 1University of Virginia, Charlottesville, VA, USA. 910.A Theoretical Analysis of the Effect of Imperfect Slice Profiles on Tagging Schemes for Pulsed Arterial Spin Labeling MRI Shella Dawn Keilholz-George1, Jack Knight-Scott2, Stuart Scott Berr2 1University of Virginia, Gordonsville, VA, USA; 2University of Virginia, Charlottesville, VA, USA. 911.Spin-oscillatory Coupling Effect in Parabolic Magnetic Field. Diagnostic Aspects Lewa Czeslaw1, Ryszard Horodecki1, Pawel Horodecki2, M. Horodecki1 1University of Gdansk, Gdansk, Poland; 2Technical University of Gdansk, Gdansk, Poland. 912.Co-evolution of MR Pulse Sequence Elements by Genetic Programming Helen Frances Gray1, Ross James Maxwell2 1City University, London, UK; 2Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex England, UK. 913.Frequency Selective RF Pulses for Multi-Slice MRI with Modest Immunity to B1 Inhomogeneity Gerald Matson1 1University of California San Francisco, S.F. V.A. Medical Center, San Francisco, CA, USA. 914.Pulse Sequence for Elimination of RF Receiver Coil Ring Down Mirko I. Hrovat1, Samuel Patz2 1Mirtech, Inc., Brockton, MA, USA; 2Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. 915.Spectral Spatial RF Pulses for 3.0T: Increased Slice Offsets with a Normal/Coarse Mode Chen Lin1, Matt Bernstein1, John Huston1, Neil Hattes2 1Mayo Clinic, Rochester, MN, USA; 2GE Medical Systems, Milwaukee, WI, USA. 916.Application of Spectro-Spatial Pulses for Contrast in Cartilage Imaging Srinka Ghosh1, Sharmila Majumdar1 1UC San Francisco - UC Berkeley, San Francisco, CA, USA. 917.Fat Suppression at 0.2T: Selecting the Best Approach Chris Flask1, Brian Dale1, David Purdy2, Jeffrey L. Duerk1, Jonathan Lewin1 1Case Western Reserve University / University Hospitals of Cleveland, Cleveland, OH, USA; 2Siemens Medical Systems, Iselin, NJ, USA. 918.Optimized RF Pulse with Both Effects of Magnetization Transfer and Fat Suppression Akihiro Ishikawa1, Naoto Iijima 1Shimadzu Corporation, Kyoto, Japan. 919.Impedance Magnetic Resonance Imaging with an External AC Magnetic Field Added to the Main Static Field Masaki Sekino1, Yasuhiro Yukawa1, Norio Iriguchi1, Shoogo Ueno1 1University of Tokyo, Graduate School of Medicine, Tokyo, Japan. 920.T1 Reduction by Applying a Small Amount of Electrical Currents Masaki Sekino1, Kikuo Yamaguchi1, Norio Iriguchi1, Shoogo Ueno1 1University of Tokyo, Graduate School of Medicine, Tokyo, Japan. 921.The Forward Problem of EEG Source Localization using Current Density Imaging Leili Torab1, Michael Joy1 1University of Toronto, Toronto, ON, Canada. 922.Intermolecular Double-Quantum Coherence Imaging of Brain Tumours at 1.5 T Geoffrey D Charles-Edwards1, Geoffrey S Payne1, Martin O Leach1, Angelo Bifone1 1The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey, UK. 923.Magnetic Field Inhomogeneity Effects on Intermolecular Multiple Quantum Coherences Richard Bowtell1, Sarah Gutteridge1, Chandrasekhar Ramanathan1 1University of Nottingham, Nottingham, England, UK. Microscopy and ESR Hall 4 Thursday: 13:30 - 15:30 924.MR Microimaging of Silicon Artificial Microstructure at 14.1 T Seung-Cheol Lee1, Kiseong Kim1, Junghyun Kim1, Soonchil Lee1, Jeong Han Yi2, Chaejoon Cheong3 1Korea Advanced Institute of Science and Technology, Taejon, Korea; 2Konkuk University, Choongju, Korea; 3Korea Basic Science Institute, Taejon, Korea. 925.MR-Microscopy at 35 µm on a Whole Body MR-System: Quality Control by Modulation Transfer Function and Applications Andreas Berg1, Heinz Wanzenboeck2, T. Hesjedal3, Ewald Moser1 1University of Vienna, Vienna, Austria; 2Vienna University of Technology, Vienna, Austria; 3Stanford University, Stanford, CA, USA. 926.Morphologic Phenotyping of a Uricase Knockout using MR Microscopy of Fixed/Stained Whole Specimens Laurence W. Hedlund1, B. Fubara1, G. P. Cofer1, S. J. Kelly1, S. L. Gewalt1, M. S. Hershfield1, G. A. Johnson1 1Duke University, Durham, NC, USA. 927.Visualization of Individual Axons in Larval Lamprey Spinal Cord by MR Microscopy Alexander Wright1, S. L. Wehrli2, M. Takahashi1, G. Zhang1, David Hackney1, M. E. Selzer1, Felix Wehrli1 1University of Pennsylvania Medical Center, Philadelphia, PA, USA; 2Children's Hospital of Philadelphia, Philadelphia, PA, USA. 928.In Vivo High-Resolution MRI of the Finger Bone at 7 T Genevieve Guillot1, David Last1, Luc Darrasse1, Michael Szimtenings2, Titus Lanz2, Axel Haase2 1U2R2M (CNRS ESA 8081), Orsay, France; 2Universität Würzburg, Würzburg, Germany. 929.MRI, a New Method for Morphological Insect Classification Stefan Wecker1, Thomas Hörnschemeyer2, Mathias Hoehn1 1Max-Planck-Institut for Neurological Research, Köln, Germany; 2University of Göttingen, Göttingen, Germany. 930.Image-Based EKG Gating for 4D-Velocity Microscopy in Embryonic Models. John C. Wood1, J. Michael Tyszka2, Russell E. Jacobs2 1Childrens Hospital of Los Angeles, University of Southern California, Los Angeles, CA, USA; 2California Institute of Technology, Pasadena, CA, USA. 931.Water and Lipid MR Imaging of the Xenopus Oocyte Jonathan V. Sehy1, Joseph J.H. Ackerman1, Jeffrey J. Neil2 1Washington University, St. Louis, MO. USA; 2St. Louis Children's Hospital, St Louis, MO, USA. 932.Electron Paramagnetic Resonance Measurement and Imaging of the Effects of Topical Antioxidants on Nitroxide Free Radical Penetration, Metabolism and Distribution in Human Skin Guanglong He1, Alexandre Samouilov1, Mohanad M. Fallouh1, Periannan Kuppusamy1, Jay L. Zweier1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA. 933.Coating of Oxygen Sensitive Paramagnetic Particles for EPR Oximetry Jiang He1, Nelson Beghein1, Bernard Gallez1 1Université catholique de Louvain, Brussels, Belgium. 934.Mapping Tissue Perfusion, Ischemic Risk Region and Redox State in the Rat Heart Using EPR Imaging Murugesan Velayutham1, Haiquan Li1, Periannan Kuppusamy1, Jay L. Zweier1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA. 935.Measurement of Longitudinal Relaxation Times of Free Radicals by Low Field Pulsed Dynamic Nuclear Polarization Marcello Alecci1, David J. Lurie2, Antonello Sotgiu1 1Universita' dell'Aquila, L'Aquila, Italy; 2University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK. 936.In Vivo Stable Spin Probes for EPR and DNP Imaging Thierry Guiberteau1, Lucien Marx2, Robert Chiarelli2, Daniel Grucker1, André Rassat2 1Université Louis Pasteur, Strasbourg, France; 2Ecole Normale Supérieure, Paris, France. 937.Comparitive Sensitivity of a pH-sensitive Spin Probe in Natural and Isotopically-Substituted States Margaret A. Foster1, Igor A. Grigor'ev2, James M.S. Hutchison1, Valery V. Khramtsov3, David J. Lurie1, Ian Nicholson1 1University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK; 2Institute of Organic Chemistry, Novosibirsk, Russia; 3Institute of Chemical Kinetics, Novosibirsk, Russia. 938.Application of PEDRI to Measure the In Vivo Distribution and Clearance of a Triaryl Methyl Radical in Mice Jay L. Zweier1, Haihong Li1, Yuanmu Deng1, Periannan Kuppusamy1, David J. Lurie2 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2University of Aberdeen, Aberdeen, Scotland, UK. 939.A Dual-Purpose 20 mT PEDRI and 0.38 T MR Imager based on a Resistive-Magnet Clinical MRI System David J. Lurie1, Haihong Li2, Jay L. Zweier2 1University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK; 2Johns Hopkins University School of Medicine, Baltimore, MD, USA. 940.Rapid Imaging of Free Radicals In Vivo using Hybrid Fast Field Cycled PEDRI Wiwat Youngdee1, David J. Lurie1, Margaret A. Foster1 1University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK. 941.T1e* and T2e* Maps Derived from Longitudinally Detected Electron Paramagnetic Resonance Phase Imaging with Application in Oxygen Mapping Ioannis Panagiotelis1, Ian Nicholson1, James M. S. Hutchison1, Margaret A. Foster1 1University of Aberdeen, Aberdeen, Scotland, UK. Hyperpolarized Gases and Non-proton MRI Hall 4 Thursday: 13:30 - 15:30 942.Whole-Lung Hyperpolarized 3He Diffusion MR Imaging using Interleaved-Spiral Trajectories Michael Salerno1, James R. Brookeman1, John P. Mugler III1 1University of Virginia, School of Medicine, Charlottesville, VA, USA. 943.High-Resolution Volumetric Imaging of the Lung Air Spaces using Hyperpolarized 3He and Spiral-Trajectory Pulse Sequences Michael Salerno1, James R. Brookeman1, John P. Mugler III1 1University of Virginia, School of Medicine, Charlottesville, VA, USA. 944.Regional Lung Compliance by Hyperpolarized 3Helium Magnetic Resonance Imaging Rahim Rizi1, J. E. Baumgardner1, P. K. Saha1, M. Aranda1, A. Asaii1, M. Frazer1, D. A. Roberts1, Mitchell Schnall1, John Leigh, Jr.1 1University of Pennsylvania, Philadelphia, PA, USA. 945.3D Hyperpolarized 3He MR Imaging of the Lung using an Interleaved-Cylindrical k-Space Trajectory Kai Ruppert1, John P. Mugler III1 1University of Virginia, School of Medicine, Charlottesville, VA, USA. 946.Functional Nonspecificity of T1-Weighted MRI of Laser-Polarized Helium-3 Gas David Roberts1, Rahim Rizi1, D. A. Lipson1, J. Hansen-Flaschen1, A. Yamomoto1, Warren Gefter1, John Leigh1, Mitchell Schnall1 1University of Pennsylvania, Philadelphia, PA, USA. 947.Low Field Lung Imaging Using Hyperpolarized 3He Colin McGloin1, Abdelmalek Benattayallah1, Richard William Bowtell1, Stan Fichele1, Alan Moody1, Paul Morgan2, John Robert Owers-Bradley1 1University of Nottingham, Nottingham, UK; 2University Hospital, Queen's Medical Centre, Nottingham, England, UK, 948.3He-MRI in Lung Transplant Recipients: A Comparison with CT Klaus Kurt Gast1, Hans-Ulrich Kauczor1, Magali Viallon1, Klaus Markstaller1, Balthasar Eberle1, Jana Lill1, E Mayer1, Michael Ulrich Puderbach1, Alexander Thomas Hanke1, Holger Finkemeier1, Wolfgang Schreiber1, Manfred Thelen1 1Klinikum Johannes-Gutenberg-Universität, Mainz, Germany. 949.Positional Dependence of Small Inferior Ventilation Defects Seen on Hyperpolarized Helium-3 MR of the Lung Jaime Mata1, Talissa Altes1, John Christophe1, John Mugler1, James Brookeman1, Eduard De Lange1 1University of Virginia, Charlottesville, VA, USA. 950.Time-Dependent Hyperpolarized 3He Diffusion MR Imaging: Initial Experience in Healthy and Emphysematous Lungs Michael Salerno1, James R. Brookeman1, John P. Mugler III1 1University of Virginia, School of Medicine, Charlottesville, VA, USA, 951.Using Dynamic Hyperpolarized Xenon MR to Measure Brain Perfusion Arvind K Venkatesh1, Kwan Soo Hong2, Lyubov Kubatina2, Yanping Sun2, Robert Mulkern3, Ferenc A. Jolesz2, Mitchell Scott Albert4 1Boston University, Boston, MA, USA; 2Brigham and Women's Hospital, Boston, MA, USA; 3The Children's Hospital, Boston, MA, USA; 4Harvard Medical School, Boston, MA, USA. 952.Rib Susceptibility Artifact on Gradient-Echo Helium-3MRI David A. Roberts1, Rahim Rizi1, D. Lipson1, A. Yamomoto1, Asaii A.1, A. Hansen-Flaschen1, Warren Gefter1, John Leigh1, Mitchell Schnall1 1University of Pennsylvania, Philadelphia, PA, USA. 953.Effects of Dilution and Oxygenation on T1 of Hyperpolarized 129Xe in Perfluorocarbon Emulsions Albert Cross1, Dan McPhee1, Giles E. Santyr1, Julia Wallace1, James J. Cheetham1, Greg Cron1 1Carleton University, Ottawa, Ontario, Canada. 954.Direct Observation of the Transport of 129Xe from the Lung-Gas to the Tissue and the Blood A.K. Venkatesh1, K.S. Hong2, L. Kubatina2, Y. Sun2, R.V. Mulkern3, F.A. Jolesz2, M.S. Albert2 1Boston University, Boston, MA, USA; 2Brigham and Women's Hospital, Boston, MA, USA; 3Children's Hospital, Boston, MA, USA. 955.New Method for Large Scale Production of Hyperpolarized Xenon Jeannette Carberry1, Michael Briggs1, Stephen Ketel1, Elizabeth Negandhi1, Mark B. Leuschner1, Bill Hersman1 1University of New Hampshire, Durham, NH, USA. 956.Morphologic 19F-MRI of Perflubron in Pig Lung during Partial Liquid Ventilation Simone Laukemper-Ostendorf1, Wolfgang Schreiber1, Claus Peter Heussel1, Alexander Scholz1, Klaus Markstaller1, Balthasar Eberle1, Norbert Weiler1, Michael Quintel2, Manfred Thelen1, Hans-Ulrich Kauczor1 1Johannes Gutenberg-University, Mainz, Germany; 2University Hospitals Mannheim, Mannheim, Germany. 957.Sodium Imaging of the Brain at 4T Using a Short TE 3D Gradient Echo Acquisition David Clayton1, Robert Lenkinski2 1University of Pennsylvania, Philadelphia, PA, USA; 2Harvard University, Beth Israel Deaconess Medical Center, Boston, MA, USA. 958.Evidence of Apoptosis in a Region of Decreased 23Na MR Signal after Acute Focal Cerebral Ischemia Robert Bartha1, Mathew Hogan2, Nagalingum Rajakumar3, Sarah Henderson1, Ravi S Menon1 1The John P. Robarts Research Institute, London, ON. Canada; 2University of Ottawa, Ottawa, ON, Canada; 3University of Western Ontario, London, ON, Canada. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) GABA Measurements in Humans & Animals Hall 2 Monday: 14:00 - 16:00 Chairs: Hoby P. Hetherington Ralph E. Hurd 14:00 959.Topiramate Increases Human Brain GABA within Thirty Minutes Ognen A.C. Petroff1, Fahmeed Hyder1, Richard H. Mattson1, Douglas L. Rothman1 1Yale University, School of Medicine, New Haven, CT, USA. 14:10 960.A J-resolved, Two Dimensional MRS Study of Brain GABA and NAA Levels in Cocaine Dependent Subjects-Before and After Treatment Yong Ke1, Chris C Streeter2, Debby A Yurgelun-Todd1, O Sarid-Segal2, Leanne Nassar1, LA Awad2, S Gruber2, CA Nason2, C Duffy2, Perry F Renshaw1 1McLean Hospital, Harvard Medical School, Belmont, MA, USA; 2VA Boston Health System, Boston University School of Medicine, Boston, MA, USA. 14:20 961.Direct In Vivo Measurement of Cerebral GABA in Humans using MEGA-editing at 7 Tesla Melissa Terpstra1, Kamil Ugurbil1, Rolf Gruetter1 1University of Minnesota, Minneapolis, MN, USA. 14:30 962.In Vivo GABA Measurement using a PRESS-Localized Double Quantum Filter in Patients with Malformations of Cortical Development and Epilepsy Mary McLean1, Robert Simister1, Friedrich Woermann1, Lawrence Wald2, Stephen Williams3, John Duncan4 1National Society for Epilepsy, Gerrards Cross, Bucks, UK; 2Harvard University, MGH-NMR Center, Charlestown, MA, USA; 3University of Manchester, Manchester, England, UK; 4University College London, London, UK. 14:40 963.GABA Detection in the Human Brain Using a 3D Localized Selective Double Quantum Filter Hidehiro Watanabe1, Masaaki Umeda1, Kazuya Okamoto1, Masanori Oda2, Tomoyuki Kanamatsu2, Yasuzou Tsukada2, Akiko Matsumoto3, Taisuke Otsuki3 1Toshiba Medical Systems R&D Center, Tochigi Japan; 2Soka University, Hachioji, Tokyo Japan; 3National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. 14:50 964.In Vivo GABA Editing with Complete Metabolite Suppression and Reduced Macromolecule Contamination at Low B0 Field Strengths Jun Shen1, Douglas L. Rothman2 1Nathan Kline Institute, Orangeburg, NY, USA; 2Yale University, School of Medicine, New Haven, CT, USA. 15:00 965.Effects of Endogenous and Exogenous Modulators of GABA Receptor Function on GABA Levels: The Menstrual Cycle Cynthia Neill Epperson1, Kristin Haga1, Graeme F. Mason1, Michael Appel1, Edward Sellers2, Gerard Sanacora1, Douglas L. Rothman1, John H. Krystal1 1Yale University, New Haven, CT, USA; 2University of Toronto, Toronto, ON, Canada. 15:10 966.Alternations in the Relationships Between Cortical Amino Acids in PMDD Kristin Haga1, C.Neill Epperson1, Douglas Rothman1, John Krystal1, Graeme Mason1 1Yale University School of Medicine, New Haven, CT, USA. 15:20 967.The Effect of Vigabatrin on Rat Brain Metabolite Levels: An In Vivo 2D Spectroscopy Study John Welch1, Kishore Kumar Bhakoo1, Nicola Sibson1, Andrew Blamire1, Ruth Dixon1, Peter Styles1 1University of Oxford, Oxford, England, UK. 15:30 968.Cerebral GABA Accumulation Following Acute GABA-Transaminase Inhibition Robin A de Graaf1, Bei Wang1, Joyce E Wall1, Douglas L Rothman1, Kevin L Behar1 1Yale University School of Medicine, New Haven, CT, USA. 15:40 969.Glutamine is the Major Precursor for GABA Synthesis in Rat Neocortex In Vivo following Acute GABA-Transaminase Inhibition Anant B. Patel1, Douglas L. Rothman1, Bei Wang1, Gary W Cline1, Kevin L. Behar1 1Yale School of Medicine, New Haven, CT, USA. Human Brain MR Spectroscopy: Epilepsy, Ischemia, and Stroke Hall 4 Tuesday: 13:30 - 15:30 970.Hippocampal and Temporal Lobe 1H-MRS in Mesio-temporal Lobe Epilepsy with Proven Gliosis. Francois Lazeyras1, Jacqueline Delavelle1, Olaf Blanke1, Gianpaolo Pizzolato1, Margitta Seeck1 1University Hospital of Geneva, Geneva, Switzerland. 971.Detection of Frontal Lobe Abnormalities in Non-Lesional TLE by MRS R Mark Wellard1, Regula S Briellmann1, Graeme D Jackson1 1Austin & Repatriation Medical Centre, Heidelberg West, Victoria, Australia. 972.Utility of Single Voxel 1H MRS in Presurgical Evaluation of Temporal Lobe Epilepsy Kejal Kantarci1, Clifford R. Jack Jr.1, Elson L. So1, Jeffrey W. Britton1, Cheolsu Shin1, Terrence D. Lagerlund1, Gregory D. Cascino1 1Mayo Clinic, Rochester, MN, USA. 973.Investigation of Biochemical Variation in Patients with Chronic Cerebral Hemodynamic Impairment: 1H MRS and PWI Studies Chang-Shin Lee1, Cheng-Yu Chen1 1Tri-Service General Hospital and National Defense Medical Center, Neihu, Taipei, Taiwan ROC. 974.Evaluation of Metabolite Concentrations in Patients with Chronically Occlusive Cerebrovascular Disease using Quantitative Proton MRS; A Correlative Study with PET data Hirotsugu Kado1, Hirohiko Kimura1, Tatsuro Tsuchida1, Yoshio Koshimoto1, Yoshiharu Yonekura1, Harumi Itoh1 1Fukui Medical University, Fukui, Fukui Japan. 975.Can Chemical Shift Imaging be used to aid Selection and Treatment Evaluation in Carotid Endarterectomy Patients? K. E. Davies1, G. Riding1, S. R. Williams1, C. McCollum1 1University of Manchester, Manchester, UK. 976.Value-Added of Combined Proton MR Spectroscopic Imaging and Diffusion-Weighted MRI to Assess the Heterogeneity of Tissue Injury during Acute Ischemic Stroke. A Human Study François Nicoli1, Yann Le Fur1, Béatrice Denis1, Jean-Philippe Ranjeva1, Sylviane Confort-Gouny1, Patrick J Cozzone1 1Faculté de Médecine, Marseille, France. 977.Magnetic Resonance Spectroscopy in Sleep Apnea Caroline Rae1, Delwyn Bartlett2, Campbell Thompson1, James Linklater3, David Joffe1, Shane A Enright4, Ron R Grunstein5 1University of Sydney, Sydney, NSW, Australia; 2St Vincent's Clinic, Sydney, Australia; 3St Vincent's Hospital, Sydney, NSW, Australia; 4University of Sydney, Royal North Shore Hospital, St. Leonards, Australia; 5Royal Prince Alfred Hospital, Sydney, Australia. 978.Effect Of Oxygen Supplementation On Intracellular Brain pH In Patients With Hypoxia Due To Chronic Obstructive Pulmonary Disease: A Phosphorus-31 MR Spectroscopy Study Joanna Allsop1, Gavin Hamilton1, Daniel Michael Forton1, Glyn Austin Coutts1, Rory James Shaw2, Simon David Taylor-Robinson1, Rajat Mathur1 1Imperial College School of Medicine, Hammersmith Hospital Campus, London, England, UK; 2Imperial College of Science, Technology and Medicine, University of London, South Kensington, London, UK. MR Spectroscopy of White Matter and Degenerative Diseases Hall 4 Tuesday: 13:30 - 15:30 979.Reference Concentrations of Choline, Creatine and NAA in Human Cerebral White Matter. Dirk Rutgers1, Jeroen Van der Grond1 1University Medical Center, Utrecht, Netherlands. 980.Age-Related Elevations in Cerebral Metabolites in the Hippocampus: A Short Echo Time Proton Magnetic Resonance Spectroscopy Study Andreana Petrova Haley1, Jack Knight-Scott1, Virginia I. Simnad1, Carol Anne Manning1 1University of Virginia, Charlottesville, VA, USA. 981.Regional and Tissue Specific Changes of Metabolite Concentration with Age using Short TE Multislice 1H-MRSI Dirk Wiedermann1, Norbert Schuff1, Joyce Suhy1, Dieter J. Meyerhoff1, Judith Licht1, Michael W. Weiner1 1University of California San Francisco, DVA Medical Center, San Francisco, CA, USA. 982.Correlating Magnetization Transfer (MT) with Single Voxel Protons (1H) Magnetic Resonance Spectroscopy (MRS) in Multiple Sclerosis (MS) Maria Concepcion Garcia Otaduy1, Dagoerto Callegaro1, Luiz Alberto Bacheschi1, Giovanni Guido Cerri1, Claudia Costa Leite1 1University of Sao Paulo, Medical School, São Paulo, Brazil. 983.Metabolite T1 in Multiple Sclerosis Lesions Differs from Normal Elana Brief1, Kenneth P Whittall1, David Li1, Alex MacKay1 1University of British Columbia, Vancouver, BC, Canada. 984.Correlation of 1H MR spectroscopy of chronic multiple sclerosis lesions with intermediary T2-component and T1-hypointensity Gunther Helms1, Leszek Stawiarz2, Hans Link2 1Karolinska Institute, Karolinska Hospital, Stockholm, Sweden; 2Karolinska Institute, Huddinge Hospital, Huddinge, Sweden. 985.Regional Comparison of Axonal Damage in Multiple Sclerosis using Whole Supratentorial Brain 3D Spectroscopy Imaging Daniel Pelletier1, Denis Grenier1, Ying Lu1, Sarah J. Nelson1, Donald E. Goodkin1 1University of California San Francisco, San Francisco, CA, USA. 986.Differentiating Alzheimer´s Disease and Vascular Dementia with Regional Metabolites Comparison by Quantitative Proton MR Spectroscopy Weimin An1, Youquan Cai2, Hongchuan Tang2, Jian-Ming Zhu3 1Naval General Hospital, Beijing, China; 2PLA General Hospital, Beijing, China; 3G. E. Medical Systems, Milwaukee, WI, USA. 987.Relations between Regional Metabolic Patterns and Specific Cognitive Dysfunctions in Alzheimer´s Disease : A 1H MRS Study Sophie Chantal1, Martin Labelle2, Abdesslem Khiat2, Yvan Boulanger2, Rémi W. Bouchard1, Claude M.J. Braun3 1Hôpital de l'Enfant-Jésus du CHA, Québec, Qc, Canada; 2Hôpital Saint-Luc du CHUM, Montréal, Qc, Canada; 3UQAM, Centre de Neurosciences Cognitives, Montréal, Qc, Canada. 988.Correlation of MR-based Hippocampal Volume and Proton Magnetic Resonance Spectroscopic Findings in Patients with Alzheimer's Disease Seong Yoon Kim1, Jung Hee Lee2, Kang Uk Lee3, Jae Kong Shin4, Jong Inn Woo4 1Asan Medical Center, University of Ulsan, Seoul, Korea; 2Asan Institute of Life Sciences, Seoul, Korea; 3Seoul National Mental Hospital, Seoul, Korea; 4SNU Hospital, Seoul National University, Seoul, Korea. 989.Efficacy of Magnetic Resonance Spectroscopy (MRS) for Clinical Diagnosis of Alzheimer´s Disease Cat-Huong Nguy1, Mya Zapata2, Frederick Shic2, Alexander Lin2, David Shieh3, Norman Chien3, Brian Ross2 1Rudi Schulte Research Institute, Santa Barbara, CA, USA; 2Huntington Medical Research Institutes, Pasadena, CA, USA; 3Huntington Memorial Hospital, Pasadena, CA, USA. 990.Applications of Neural Network Analyses to In Vivo 1H MR Spectroscopy of Parkinson's Disease Patients Ingrid Susann Gribbestad1, Inger Johanne Bakken1, David Axelson2, Gunnar Nilsen3, Benny Ehrnholm3, Jan Aasly4 1SINTEF Unimed, Trondheim, Norway; 2MRi_Consulting, Kingston, ON, Canada; 3MR Center, Trondheim, Norway; 4University Hospital, Trondheim, Norway. 991.Monitoring the DL-(-Hydroxybutyrate Treatment of a Patient with Hyperinsulinism Vladimir Mlynarik1, Stephan Gruber1, Sylvia Stoeckler1, Barbara Plecko1, Hans Silgoner1, Ewald Moser1 1University of Vienna, Vienna, Austria. 992.Longitudinal Corticospinal Tract Changes in ALS by 1H MRSI Joyce Suhy1, Robert G. Miller1, Norbert Schuff1, Ria C Lopez1, Andrew A. Maudsley1, Michael W. Weiner1 1University of California San Francisco, San Francisco, CA, USA. 993.Functional Correlates of Neuronal Loss in Gulf War Syndrome Robert Ware Haley1, F Petty2, J Kramer2, P S Roland1, James L Fleckenstein1 1University of Texas Southwestern Medical Center at Dallas, Southwestern Medical School, Dallas, TX, USA; 2Department of Veterans Affairs Medical Center, Dallas, TX, USA. 994.Metabolic Abnormalities in the Brain of Subjects with Gulf War Illness Dieter J Meyerhoff1, Joselyn Lindgren1, Dawn Hardin1, J. Mcleod Griffis2, Michael W Weiner1 1University of California San Francisco, VA Medical Center, San Francisco, CA., USA; 2University of California San Francisco, San Francisco, CA, USA. 995.Changes in High Energy Phosphate Metabolism in White and Grey Matter in Normal Pressure Hydrocephalus: A Phosphorus Spectroscopy Study Robin Corkill1, Matthew Romney Garnett1, Andrew Blamire1, Balasubramanian Rajagopalan2, Tad Cadoux-Hudson3, Peter Styles1 1University of Oxford, John Radcliffe Hospital, Oxford, England, UK; 2Dept. of Radiological Sciences, Oklahoma City, OK, USA; 3University of Oxford, Oxford, UK. 996.Chronic Alcohol Consumption and HIV Infection: Effects on Brain Structure and Metabolites Dieter J Meyerhoff1, Valerie A Cardenas1, Michael W Weiner1 1University of California San Francisco, VA Medical Center, San Francisco, CA, USA. 997.1H MRS Suggests Derangement in Glial and Myelin Support to Neurons in Encephalopathy due to Occupational Exposure to Organic Solvents Kim Vuori1, Sainio Markku2, Jesper Lundbom1, Tapio Vehmas2, Anna-Maija Häkkinen1, Kiti Müller2, Nina Lundbom1 1Helsinki University Central Hospital, Helsinki, Finland; 2Finnish Institute of Occupational Health, Helsinki, Finland. 998.Role of Phospholipase A2 in the Modulation of Membrane Markers Observed by 1H and 31P MRS in Brain Diseases Yvan Boulanger1, Abdesslem Khiat1, Martin Labelle1 1Hôpital Saint-Luc du CHUM, Montréal, Qc, Canada. MR Spectroscopy of Human Neurological Disorders Hall 4 Tuesday: 13:30 - 15:30 999.Quantitative Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopic Imaging (MRSI) of Dorsolateral Prefrontal Cortex in Children with Fetal Alcohol Syndrome. Bernadette M Cortese1, John H Hannigan1, Gregory J. Moore1 1Wayne State University, Detroit, MI, USA. 1000.Evaluation of Changes in Brain Metabolite Levels in Acute Disseminated Encephalomyelitis: An In Vivo 1H MRS Study Wei Huang1, Lidia Gabis1, Mirjana Savatic1, Terry M. Button1, Nicholas J. Lenn1 1State University of New York at Stony Brook, Stony Brook, NY, USA. 1001.1HMRS of Blood and Brain in a Case of Rhizomelic Chondrodysplasia Punctata Angèle Viola1, Brigitte Chabrol2, Francisca Vintila2, Sylviane Confort-Gouny1, Patrick Viout1, Jean-Philippe Ranjeva1, Farid Boubred2, Patrick Cozzone1 1Faculté de Médecine, Marseille, France; 2Hôpital la Timone, Marseille, France. 1002.Entire Hemispheric Proton In Vivo MRS Examination of Sturge-Weber Syndrome at 3 T Hee-Won Kim1, Angela P. Bruner1, Bernard L. Maria1, Katherine N. Scott1 1University of Florida, Gainesville, FL, USA. 1003.Proton Spectroscopy in Tuberous Sclerosis Complex Iain D Wilkinson1, William Mukonoweshuro1, Paul D Griffiths1 1University of Sheffield, Royal Hallamshire Hospital, Sheffield, England, UK. 1004.Intracellular pH Measurements of the Whole Head and the Basal Ganglia in Chronic Hepatic Encephalopathy: A Phosphorus-31 MR Spectroscopy Study Nayna Patel1, Daniel Forton2, Gavin Hamilton1, Glyn A Coutts3, Howard Christopher Thomas4, Simon David Taylor-Robinson2 1Hammersmith Hospital Campus, Imperial College School of Medicine, London, England, UK; 2Hammersmith Hospital Campus/St Mary's Hospital Campus, Imperial College School of Medicine, London, England, UK; 3Marconi Medical Systems, Hammersmith Hospital, Imperial College School of Medicine, London, England, UK; 4St Mary's Campus, Imperial College School of Medicine, London, England, UK. 1005.Proton-Decoupled 31P MR Spectroscopic Imaging of Radiation-Induced Temporal Lobe Necrosis David Yeung1, Yu-Leung Chan2, Heinz-Peter Schlemmer3, Sing-Fai Leung1, Peter Bachert3 1Prince of Wales Hospital, Shatin, Hong Kong, China; 2Chinese University of Hong Kong, Shatin, Hong Kong, China; 3German Cancer Research Centre, Heidelberg, Germany. 1006.MR-Spectroscopy of the Spinal Cord of Professional Cyclists and controls Martin Büchert1, Carsten Altehoefer1 1University of Freiburg, Freiburg, Germany. 1007.Abnormal 13C Glucose Metabolism in Patients with Chronic Hepatic Encephalopathy Stefan Bluml1, Angel Moreno-Torres1, Brian Ross2 1Rudi Schulte Research Institute, Santa Barbara, CA, USA; 2Huntington Medical Research Institutes, Pasadena, CA, USA. 1008.Long-term Brain Metabolic Alterations in Exogenous Cushing's Syndrome as Monitored by Proton Magnetic Resonance Spectroscopy Abdesslem Khiat1, Céline Bard2, André Lacroix2, Martin Labelle1, Yvan Boulanger1 1Hôpital Saint-Luc du CHUM, Montréal, Québec, Canada; 2Hôtel-Dieu du CHUM, Montréal, Québec, Canada. 1009.Proton Magnetic Resonance Chemical Shift Imaging(1H CSI)-directed Stereotactic Biopsy Hyeon-Man Baik1, Byung-Chul Son1, Bo-Young Choe1, Tae-Suk Suh1, Hyoung-Koo Lee1, Kyung-Sub Shinn1 1Catholic University of Korea, Seoul, Korea. 1010.Choline Imaging with PET and 2D-CSI in a Human Brain Astrocytoma Medhi Adinehzadeh1, Raymond Poelstra1, Martin Jackob1, Joseph Mantil1, Jogeshwar Mukherje1, Brad Christian1, Bingshi Zhi1, Michael Kent1, Bilal Ezzeddine1 1Wallace-Kettering Neuroscience Institute, Kettering, OH, USA. MR Spectroscopy of Human Psychiatric Disorders Hall 4 Tuesday: 13:30 - 15:30 1011.Detection of Cerebral Gamma-aminobutyric Acid (GABA) in Biopolar Disorder Patients and Healthy Volunteers at 3T Napapon Sailasuta1, Patrick Leroux2, Ralph Hurd1, Paul Wang3, N. Sachs4, Terrence Ketter4 1 G. E. Medical Systems Group, Fremont, CA USA; 2Palaiseau, France; 3Don Mills, Ontario Canada; 5Stanford University, Stanford, CA, USA. 1012.No Significant Change of Brain Myo-Inositol is Observed in Bipolar Affective Disorder after Sodium Valproate Medication by In Vivo Proton MR Spectroscopy Ren Hua Wu1, Peter H Silverstone1 1University of Alberta, University of Alberta Hospital, Edmonton, Alberta, Canada. 1013.Neurochemical Correlates of Late-Life Major Depression Anand Kumar1, Albert Michael Thomas1, Helen Lavretsky1, Arthur Toga1, Michael Mega1, Daniel Pham1, Kenneth Yue1, Amir Huda1, Talaignair Nagaraj Venkatraman1 1UCLA School of Medicine, Los Angeles, CA, USA. 1014.Follow-up Investigation of Hippocampal Choline in Depression after ECT Gabriele Ende1, Thomas S Obergriesser1, Wolfgang Weber-Fahr1, Fritz A Henn1 1Central Institute of Mental Health, Mannheim, Germany. 1015.4.0 Tesla Measurements of N-acetylaspartate, Glutamate and Glutamine in the Anterior Cingulate and Thalamus of Schizophrenic Patients Pre and Post Treatment J. Théberge1, D. J. Drost1, P. C. Williamson1, R. Bartha2, A K Malla1, Y. Al-Semaan1, R. Wj Neufeld1, R. S Menon2 1University of Western Ontario, London, ON, Canada; 2Robarts Research Institute, London, ON, Canada. 1016.Membrane Phospholipid Metabolite Alterations in Prefrontal and Basal Ganglia Regions in Schizophrenia: An In Vivo 31P and 1H MRSI Study Jeffrey A. Stanley1, Matcheri S. Keshavan1, Kanagasabai Panchalingam1, Richard J. McClure1, Jay W. Pettegrew1 1University of Pittsburgh, Western Psychiatric Institute & Clinic, Pittsburgh, PA, USA. 1017.Focal and Generalized Membrane Phospholipid Metabolite Alterations in Child and Adolescent Offspring of Schizophrenia and Schizoaffective Disorder Subjects: An In Vivo 31P MRSI Study Jeffrey A. Stanley1, Jay W. Pettegrew1, Kanagasabai Panchalingam1, Richard J. McClure1, Keith Harenski1, Debra M. Montrose1, Matcheri S. Keshavan1 1University of Pittsburgh, Western Psychiatric Institute & Clinic, Pittsburgh, PA, USA. 1018.1H MRSI of the Cerebellum and Pons: Metabolite Distribution in Controls and Schizophrenics Gabriele Ende1, Petra Hubrich-Ungureanu1, Nina Kämmerer1, Fritz A Henn1 1Central Institute of Mental Health, Mannheim, Germany. 1019.Acute Fire-related Posttraumatic Stress Disorder: MR Imaging and 1H MR Spectroscopic Findings Myung Kwan Lim1, Jeong Seop Lee1, Chang Hae Suh1 1Inha University College of Medicine, Incheon, South Korea. 1020.Study of Systemic Lupus Erythematosus: Correlation of Clinical Findings with MRI, MRS and SPECT. Preeti Sahota1, Mahesh Kumar1, Rohini Handa1, C.S Bal1, M. Gulati1, B.M Tripathi1, N.R Jagannathan1, J.P Wali1 1All India Institute of Medical Sciences, Ansari Nagar, New Delhi India. 1021.Metabolic Changes in the Brain of Depressive Patients Stephan Gruber1, Richard Frey1 Vladimir Mlynarik1, Angela Heiden1, Siegfried Kasper1, Ewald Moser1 1University of Vienna, Vienna, Austria. MR Spectroscopy of Animal Brain Hall 4 Tuesday: 13:30 - 15:30 1022.PRESS Sequences with Very Short Echo Times using Asymmetric RF Pulses. Application to the Rat Brain In Vivo. Christian Geppert1, Wolfgang Dreher1, Dieter Leibfritz1 1University of Bremen, Bremen, Germany. 1023.High Resolution Fast Spectroscopic Imaging of Water 1H Resonance in Rat Brain Weiliang Du1, Xiaobing Fan, Marta Zamora, Gregory Karczmar 1University of Chicago, Chicago, IL, USA. 1024.Rapid Estimation of Cerebral Glucose Metabolism in the Rat David Marshall Cohen1, Michael Quast2, Jingna Wei2, Xiaolian Gao3, E. O'Brian Smith1, Louis Sokoloff4 1Baylor College of Medicine, Houston, TX, USA; 2University of Texas Medical Branch at Galveston, Galveston, TX, USA; 3University of Houston, Houston, TX, USA; 4National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. 1025.17O Relaxation Time and NMR Sensitivity of Cerebral Water and Their Field Dependence Xiao-Hong Zhu1, Hellmut Merkle1, Jaehwan Kwag1, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA. 1026.Choline Transport and Metabolism in the Aging Rat Brain Rachel Katz-Brull1, Alexei R. Koudinov1, Hadassa Degani1 1Weizmann Institute of Science, Rehovot, Israel. 1027.Longitudinal Proton MRS Study of the Metabolic Changes During Lesion Progression in Experimental Allergic Encephalomyelitis Mahaveer Degaonkar1, Rama Jayasundar1, N. R. Jagannathan1 1All India Institute of Medical Sciences, New Delhi, India. 1028.Brain and Immune Changes in Response to Psychosocial Stress Are Reversed by Tianeptine Thomas Michaelis1, G. De Biurrun2, Tokuko Watanabe3, Jens Frahm1, M. van Kampen4, E. Fuchs4, C. Hiemke5, B. van't Hart6, Brok H6, A. Bartolumuci7, C. Muñoz8 1Biomedisinische NMR Forschungs GmbH, MPI für biophysiklische Chemie, Göttingen, Germany; 2Biomedizinische NMR Forschungs GmbH, Göttingen, Germany; 3Tokyo University of Fisheries, Tokyo, Japan; 4DPZ, Göttingen, Germany; 5University Mainz, Mainz, Germany; 6BPRC, Rijswijk, The Netherlands; 7University Parma, Parma, Italy; 8I.R.I. Servier, Courbevoie, France. 1029.In Vivo 2D 1H-MRS of Metabolic Changes Following Transient Focal Cerebral Ischemia in the Rat Florence Delmas1, Wouter B. Veldhuis2, Boudewijn Van der Sanden2, Brigitte Gillet3, Jean-Claude Beloeil3, Klaas Nicolay4 1CNRS, Gif-sur-Yvette, France; 2Image Sciences Institute, Utrecht, Netherlands; 3ICSN CNRS, Gif/Yvette, France; 4University Utrecht, Utrecht, Netherlands. 1030.Effects of a Glutamate Transport Inhibitor on Brain Metabolism Caroline Rae1, Charbel E-H Moussa1, William A Bubb1, Vladimir Balcar1 1University of Sydney, Sydney, NSW, Australia. 1031.GABAergic and Glutamatergic Neurotransmitter Cycling in the Rat Cortex Anant B. Patel1, Robin A. de Graaf1, Graeme F. Mason1, Gary W. Cline1, Vincent Lebon1, Gerald I. Shulman1, Robert G. Shulman1, Douglas L. Rothman1, Kevin L. Behar1 1Yale University School of Medicine, New Haven, CT, USA. 1032.13C Spectroscopic Evidence for Regionally Specific Alterations in Neuronal Activity under General Anesthesia P. N. Venkatasubramanian1, Alice M. Wyrwicz1 1Evanston Northwestern Healthcare, Evanston, IL, USA. 1033.From Metabolic Neurotoxicity to Hypoxic Neuroprotection: An MRS Study of Cyclosporine Role in Rat Brain. Natalie Serkova1, Paul Donohoe2, Sven Gottschalk1, Carsten Hainz1, Uwe Christians2, Dieter Leibfritz1 1University of Bremen, Bremen, Germany; 2University of California San Francisco, San Francisco, CA, USA. 1034.Development of High Field Proton Spectroscopic Imaging for the Mouse Brain Gerald B. Matson1, T. C. Hill1, V. Govindaraju1 1Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA, USA. 1035.Temporal and Regional Changes in NAA in the Pathogenesis of Spongiform Encephalopathy Y-L Chung1, J Barr2, J R Fraser2, J D Bell1 1Imperial College School of Medicine, Hammersmith Hospital, London, U.K.; 2Institute for Animal Health, Edinburgh, UK. MR Spectroscopy: Animal and Cell Studies Hall 4 Wednesday: 13:30 - 15:30 1036.Effect of Fasting on 2H-Enrichment Levels of Rat Plasma Glucose as measured by 2H NMR Spectroscopy Following Infusion of 2H2O. JG Jones1, Dean Sherry1, Craig R. Malloy1 1University of Texas Southwestern Medical Center at Dallas, Southwestern Medical School, Dallas, TX, USA. 1037.The Effects of Intestinal Ischaemia and Reperfusion on Neonatal Liver Metabolites: In Vitro 1H Magnetic Resonance Spectroscopic Study S. B. Williams1, S. R. Williams2, Agostino Pierro1 1University College London, Institute of Child Health, London, UK; 2University of Manchester, Manchester, England. 1038.Value of MR and 31P MRS in the Evaluation of Experimental Testicular Trauma M. Srinivas1, Mahaveer Degaonkar1, V. V.S.S. Chandrasekharam1, N. R. Jagannathan1, D. K. Gupta1, D. K. Mitra1 1All India Institute of Medical Sciences, New Delhi, India. 1039.Rosiglitazone Reduces Liver Lipid in Zucker Rat: A 1H MRS Study Paul D Hockings1, Kumar K Changani1, Alan White1, David G Reid1, C Nigel Toseland1, Jeffrey M Birmingham1, Janette A Osborne1, David Templeton1, Robin E Buckingham1 1SmithKline Beecham Pharmaceuticals, Welwyn, UK. 1040.Metabolic Perturbations in Glucose Perfused Rat Hearts with and without Insulin: A 13C-NMR Study of Aspartate Synthesis Induced by a Sudden Suppression of Insulin Son Tran-Dinh1, J. A. Hoerter2, P. Mateo2, M. Herve1 1SBPM/DBCM, CEN-Saclay, Gif-sur-Yvette, France; 2Universite Paris Sud, Paris, France. 1041.Ethanol Perfusion Increases Efficiency of Oxidative Phosphorylation in Isolated Liver of Fed Rats Pierre Tissier1, M. C. Delmas-Beauvieux1, P. Couzigou2, H. Gin1, P. Canioni1, J. L. Gallis1 1RMSB UMR, Bordeaux, France; 2Hopital Haut-Leveque, Pessac, France. 1042.31P and 23Na NMR Spectroscopy Demonstrate Glyburide Effects on Bioenergetics and Na+ Transport in Pancreatic Beta-HC9 Cells Nicolai Doliba1, Marko Vatamaniuk1, Carol Buettger1, Heather Collins1, Wei Qin1, Suzanne Wehrli2, Franz Matschinsky1 1University of Pennsylvania, School of Medicine, Philadelphia, PA, USA; 2Children's Hospital of Philadelphia, Philadelphia, PA, USA. 1043.Role of Substrate Selection and Intracellular Compartmentation for the Metabolic Trafficking between Astrocytes and Neurons Claudia Zwingmann1, Christiane Richter-Landsberg2, Roger Frank Butterworth3, Dieter Leibfritz4 1University of Bremen and Hospital Saint-Luc, University of Montreal, Bremen, Germany; 2University of Oldenburg, Oldenburg, Germany; 3Hospital Saint-Luc, University of Montreal, Montreal, Canada; 4University of Bremen, Bremen, Germany. 1044.High Glucose Levels do not Stimulate TCA Cycle Flux in bHC9 Insulinomas Detected with 13C NMR Anthony Mancuso1, Christophe Desbarats1, Susanne Wehrli2, Franz M Matschinsky1, Jerry Glickson1 1University of Pennsylvania, Philadelphia, PA, USA; 2Children's Hospital of Pennsylvania, Philadelphia, PA, USA. 1045.A Comparison of 87Rb+ and 133Cs+ transport in Perfused Rat Heart Paul A. Schornack1, Joseph J.H. Ackerman2 1University of Arizona, Arizona Health Sciences Center, Tucson, AZ, USA; 2Washington University, School of Medicine, St. Louis, MO, USA. MR Spectroscopy: Human Body and Other Hall 4 Wednesday: 13:30 - 15:30 1046.Proton Magnetic Resonance Spectroscopy for Assessment of Human Body Composition Masayuki Kamba1, Wei Chen1, Koji Kimura2, Masahiko Koda2, Toshihide Ogawa2 1University of Minnesota, Minneapolis, MN, USA; 2Tottori University Faculty of Medicine, Nishi-machi, Yonago, Japan. 1047.Short Acquisition Time 2D COSY Localised in Human Bone Marrow Andrew P Prescot1, David J Collins1, Andrzej Dzik-Jurasz1, Martin O Leach1 1Royal Marsden Hospital, Sutton, Surrey, England, UK. 1048.The Use of in Vivo 31P Magnetic Resonance Spectroscopy for the Evaluation of Age Related Effects in Human Skin Francis Vial1, Sébastien Savard1, Lieve Declercq2, Fabrice Perin3, Patrick Beau3, Daniel Maes2 1INSERM-FRANCE, Faculté de Médecine, Tours, France; 2Estee Lauder Coordination Center, Belgium; 3Spincontrol Society, Tours, France. 1049.Effect of Oral D-tagatose on Liver Volume and Hepatic Glycogen Accumulation in Healthy Male Volunteers Chris Boesch1, Michael Ith1, Bruno Jung1, Karin Bruegger1, Sidona Erban1, Ioannis Diamantis2, Roland Kreis1, Albert Bär3 1University & Inselspital, Bern, Switzerland; 2Inselspital, Bern, Switzerland; 3Bioresco Ltd., Basel, Switzerland. 1050.31P-MR Spectroscopy of the Human Kidney Graft by 2D-CSI Sequence. Preliminary Clinical Results. Pavlina Harantova1, Monika Dezortova2, Zdenek Tosner2, Jiri Lacha2, Petr Taborsky2, Milan Hajek2 1Institut of Clinical and Experimental Medicine, Prague, Czech Republic; 2IKEM, Czech Republic. 1051.Heterogeneity of Normal Breast Investigated by In Vivo MR Spectroscopy: Determination of W/F Ratios and T1 Relaxation Times Mahesh Kumar1, N. R. Jagannathan1 1All India Institute of Medical Sciences, New Dehli, India. 1052.High Resolution 1H NMR Study of Hepatic Bile from Donors and Recipients in Human Liver Transplantation H. G. Parkes1, H. V. Melendez2, M. Rela2, G. M. Murphy3, N. D. Heaton2 1Institute of Child Health, University College London, London, England, UK; 2King's College Hospital, London, England, UK; 3King's College London, Guy's, King's and St. Thomas's School of Medicine, London, England, UK. 1053.Measurement of the Astrocytic TCA Cycle Flux in Humans Using 13C Labeled Acetate Vincent Lebon1, Kitt F. Petersen1, Gary W. Cline1, Jun Shen2, Graeme F. Mason1, Sylvie Dufour1, Kevin L. Behar1, Gerald I. Shulman1, Douglas L. Rothman1 1Yale University, School of Medicine, New Haven, CT, USA; 2Nathan S. Kline Institute, Orangeburg, NY, USA. 1054.Assessment of Cerebral Acetate Oxidation and Glial Metabolism in Human Brain by 13C MRS Stefan Bluml1, Angel Moreno-Torres1, Brian Ross2 1Rudi Schulte Research Institute, Santa Barbara, CA, USA; 2Huntington Medical Research Institutes, Pasadena, CA, USA. 1055.The Effects of Moderate Hypothermia on Intestinal Ischaemia-Reperfusion: High Resolution 1H and 31P Magnetic Resonance Spectroscopy Study Paisarn Vejchapipat1, Stephen R. Williams2, Edward Proctor1, Lewis Spitz1, Agostino Pierro1 1Institute of Child Health, University College London, London, UK; 2University of Manchester, Manchester, UK. Cardiovascular MR Spectroscopy Hall 4 Wednesday: 13:30 - 15:30 1056.NMR and Biomechanical Characteristics of Normal and Aneurysm Aortas: In Vitro Study Simeon Ivanov Petkov1, Philippe Vinee2 1Technical University og Gabrovo, Gabrovo, Bulgaria; 2Centre d’Imagerie Médicale, Selestat, France. 1057.Singlet Oxygen Energy effect in a Hamster to Rat Heart Xenotransplantation Model, Measured by In Vivo 31P NMR Spectroscopy Ann Lindgård1, Olivier Rakotonirainy, Jacob Wilton, Andreas Lundgren, Daniel Lukes, M Olausson, Bassam Soussi 1Wallenberg Laboratory, Sahlgrenska Hospital, Gothenburg, Sweden. 1058.Cellular Glucose Uptake in the Isolated Rat Heart is not Altered in Heart Failure due to Chronic Coronary Ligation Jens Höning1, Lisa Bauer1, Michael Horn1 1Medizinische Klinik, Würzburg, Germany. 1059.Susceptibility to Ischemia/Reperfusion Injury is not Increased in Rat Hearts post Myocardial Infarction Michael Horn1, Stephanie Hügel1, Kai Hu1, Stefan Neubauer2 1Medizinische Universitaetsklinik, Wuerzburg, Germany; 2John Radcliffe Hospital, Oxford, UK. 1060.Influence of Ischemic Preconditioning on Intracellular Sodium and pH in Isolated Perfused Heart Andriy Babsky1, Shahryar K. Hekmatyar1, Suzanne Wehrli2, Mary Osbakken3, Navin Bansal1 1University of Pennsylvania, Philadelphia, PA, USA; 2Children's Hospital, Philadelphia, PA, USA; 3Aventis, Bridgewater, NJ, USA. 1061.Ischemic Blockade of the Cardiac Na+/H+-Exchanger: A Simultaneous 23Na and 31P Study Michiel Ten Hove1, Jan G. Van Emous1, Cees J.A. Van Echteld1 1ICIN and University Medical Center, Utrecht, The Netherlands. 1062.Intracellular Na Concentration in a Rodent Heart during Multiple Dose Cardioplegia. Effects of Oxygen and Carbon Dioxide Victor D. Schepkin1, William M. DeCampli2, Isaac O. Choy3 1University of Illinois at Urbana-Champaign, Urbana, IL, USA; 2Children's Hospital of New Jersey, Newark, NJ, USA; 3University of California at San Francisco, San Francisco, CA, USA. 1063.Effects of Energy Deprivation on Sarcolemmal and Mitochondrial Potassium Fluxes in Rat Hearts: 87Rb and 31P NMR study. Olga Jilkina1, Bozena Kuzio2, Valerie Kupriyanov2 1University of Manitoba, Winnipeg, MB, Canada; 2National Research Council, Winnipeg, MB, Canada. 1064.Myocardial Substrate Oxidation During Cardioplegic Arrest With Potassium Chloride or Tetrodotoxin Timothy T. Hamilton1, Paul E. Meyer1, M. Peter Tauriainen1, Robert Y. Chao1, Michael E. Jessen1 1University of Texas Southwestern Medical Center, Dallas, TX, USA. 1065.Effects of Magnesium on Myocardial Energy Metabolism: Assessment in Dahl Salt- Sensitive Rats by 31P NMR Kunio Tanaka1, Nobuyuki Akita1, Mitsutosi Kusakabe1, Takashi Haneda1, Kenjirou Kikuchi1 1Asahikawa Medical College, Asahikawa, Japan. 1066.The Effects of NHE Inhibition in a Canine Cardiac Ischemia/Reperfusion Model: A MRI/MRS Study Kerry Thompson1, R. Terry Thompson1, Jane Sykes1, Gerald Wisenberg1 1University of Western Ontario, London, ON, Canada. 1067.Variability and Reproducibility of Quantitative 31P NMR Spectroscopy of the Human Heart Michael Bunse1, Oliver Schmidt1, Otto Lutz2, Günther J. Dietze1, Wulf-Ingo Jung1 1Max Grundig Clinic, Bühl, Germany; 2Physikalisches Institut der Universität Tübingen, Tübingen, Germany. 1068.Increased Phosphocreatine Depletion in Early Exercise in the Marfan Syndrome: A Clinical Model of Endothelial Dysfunction Jenifer Crilley1, E.A. Boehm1, David Bendahan1, Balasubramanian Rajagopalan2, Peter Styles1, Wordsworth P3, Kieran Clarke1 1University of Oxford, Oxford, England, UK; 2Dept. of Radiological Sciences, Oklahoma City, OK, USA; 3Nuffield Orthopaedic Centre, Oxford, England, UK. Musculoskeletal MR Spectroscopy Hall 4 Wednesday: 13:30 - 15:30 1069.Intramyocellular Lipids (IMCL), Plasma Leptin System and Glucose Uptake in Women with a History of Gestational Diabetes (GDM). Martin Krssak1, Alexandra Kautzky-Willer1, Giovanni Pacini2, Harald Stingl1, Georg Brabant3, Oswald F. Wagner4, Werner Waldhäusl1, Michael Roden1 1University of Vienna, Wien, Austria; 2Inst. Syst. Sci. & Biomed. Engn., Padua, Italy; 3Medizinische Hochshule, Hannover, Germany; 4University Hospital Vienna, Wien, Austria. 1070.Orientation Dependent Splitting of the Intra-Myocellular Lipid Resonance in Rat Muscle: A MRS Study at 7T C. Franke1, U. Belz1, J. Kuhlmann1, A.W. Herling1, H.-P. Juretschke1 1Aventis Pharma Deutschland GmbH, Frankfurt, Germany. 1071.Higher Fatty Acids Oxidation Prevents Intramyocellular Lipid (IMCL) Accretion and insulin Resistance in Humans with Moderate increment of Body Fat Mass. Paola Scifo1, Emanuela Pagliato2, Stefano Benedini1, Marianna Caloni1, Francesco De Cobelli1, Alessandro Del Maschio1, Livio Luzi1, Gianluca Perseghin1 1Scientific Institute H San Raffaele, Milan, Italy; 2University of Milan, Milan, Italy; 1072.Dietary Manipulation of Insulin Sensitivity Does Not Affect Muscle Triglycerides Louise Goff1, Gary S Frost1, Timothy J Aitman1, E Louise Thomas1, Jimmy D Bell1 1Imperial College School of Medicine, Hammersmith Hospital, London, UK. 1073.Regional Differences of the Magnetic Field Distribution of IMCL and EMCL Signals from Human Calf Muscles G. Steidle1, J. Machann1, K. Brechtel1, C. D. Claussen1, F. Schick1 1University of Tuebingen, Tuebingen, Germany/ 1074.Intramyocellular Lipid (IMCL) Stores Before and After a Fat Rich Diet Klaus Brechtel1, Dominik B Dahl1, Juergen Machann1, Oliver P Bachmann1, Stephan Jacob1, Hans U Haering1, Claus D Claussen1, Fritz Schick1 1University of Tuebingen, Tuebingen, Germany. 1075.Relationship Between Carnitine and Intramyocellular Lipids in Three Human Muscles Observed by 1H Spectroscopic Imaging at 4T J.-H. Hwang1, J. W. Pan1, J. H. Lee2, B. Balent1, Hoby Hetherington3, D. T. Stein1 1Albert Einstein College of Medicine, Bronx, NY, USA; 2Brookhaven National Laboratory, Upton, NY, USA; 3Yeshiva University, Albert Einstein College of Medicine, Bronx, NY, USA. 1076.Monitoring the Changes of Intramyocellular Lipids in Response to the Suppression of Substrate Availability Using 1H Spectroscopic Imaging at 4T Dan T. Stein1, Jong-Hee Hwang2, J.-H. Lee1, B. Balent1, Hoby Hetherington2, Jullie W. Pan1 1Albert Einstein College of Medicine, Bronx, NY, USA; 2Yeshiva University, Albert Einstein College of Medicine, Bronx, NY, USA. 1077.1H MRS of the Intra-Myocellular Lipid Content in the m. vastus lateralis. Marianne Eline Kooi1, Patrick Schrauwen2, Marco Mensink2, Anton J.M. Wagenmakers2, Gerrit J. Kemerink1, Ellen E. Blaak2 1University Hospital of Maastricht, Maastricht, The Netherlands; 2Maastricht University, Maastricht, The Netherlands. 1078.Efficacy of Fish-oil Cardio-preventive Diet as a Modulator of Human Lipid Composition: 13C MRS In Vivo Jung-Hee Hwang1, Stefan Bluml1, Alexander Leaf2, Brian Ross3 1Rudi Schulte Research Institute, Santa Barbara, CA, USA; 2Massachusetts General Hospital, Charlestown, MA, USA; 3Huntington Medical Research Institutes, Pasadena, CA, USA. 1079.Local Perfusion and Metabolic Demand During Exercise: A Non-Invasive MRI Method of Assessment Russell S Richardson1, Luke J Haseler1, Stephan Bluml2, Lawrence Frank3 1UC, San Diego, La Jolla, CA, USA; 2Huntington Medical Research Insitute, Pasadena, CA, USA; 3University of California, San Diego, VA Medical Center, San Diego, CA, USA. 1080.Additonal Phases in PCr Use during a Sustained Isometric Exercise of the Tibial Anterior Muscle, Studied by 31P NMRS Caroline J. Houtman1, Arend Heerschap1, Machiel J. Zwarts1, Dick F. Stegeman1 1University Medical Centre, Nijmegen, The Netherlands. 1081.Comparison of Magnesium (Mg2+) and ATP Abnormalities in Muscle Disorders: Fibromyalgia, Dermatomyositis and Scleroderma Kenneth J. Niermann1, Jane H. Park1, Rebecca J. Meyer1, David A. Gilpin1, Lloyd E. King1, Nancy J. Olsen1 1Vanderbilt University, School of Medicine, Nashville, TN, USA. 1082.Calculating Metabolite Concentrations in Resting Muscle using 31P MRS David Manners1, Peter Styles1, Doris Taylor1 1John Radcliffe Hospital, Oxford, England, UK. 1083.PCr Resynthesis during Muscle Stimulation is Affected by Oxygen Availability. An in vivo 31P-MRS Study in Rat Gastrocnemius Muscle. Benoit Giannesini1, David Bendahan1, Marguerite Izquierdo1, Patrick J. Cozzone1 1Faculté de Médecine de Marseille, Marseille, France. 1084.1H MR Spectral Features Correlate with Measures of Tissue Vascularity in the Synovial Joints of Rheumatoid Arthritis Patients Tedros Bezabeh1, C. Hitchon2, J. Canvin2, R. Patel1, H. El-Gabalawy2 1National Research Council of Canada, Winnipeg, MB, Canada; 2Health Sciences Centre, Winnipeg, MB, Canada.1085.Skeletal Muscle High-Energy Phosphates and Oxygen Metabolism during Voluntary and Electrically-Stimulated Isometric Contractions: Comparison using Interleaved 1H/31P-NMRS S. Duteil1, M. Vanderthommen2, J. S. Raynaud1, C. Wary1, Anne Leroy-Willig3, J.M. Crielaard2, Pierre Carlier4 1Pitie-Salpetriere University Hospital, Paris, France; 2Sart-Tilman University Hospital, Liege, Belgium; 3AFM, CEA and INSERM U494, Paris, France; 4Jemeppe-Sur-Sambre, Belgium. 1086.The Impaired Oxidative Energy Metabolism in the Calf Muscle of Immobilised Healthy Subjects and Patients with Friedreich's Ataxia and Huntington's Disease Jochen Zange1, Klaus Mueller1, Carsten Saft2, Ludger Schoels2, Matthias Vorgerd3 1German Aerospace Center, Cologne, Germany; 2St. Josef Hospital, Ruhr-University-Bochum, Bochum, Germany; 3Kliniken Bergmannsheil, Ruhr-University-Bochum, Bochum, Germany. 1087.Investigation of Fluoroquinolone-Induced Myalgia using 31P Magnetic Resonance Spectroscopy and In Vitro Contracture Tests Sandrine Guis1, David Bendahan1, Genevieve Kozak-Ribbens1, Jean-Pierre Mattei1, Yann Le Fur1, Dominique Figarella-Branger1, Jacqueline Jouglard1, Patrick J. Cozzone1 1Faculté de Médecine, Marseille, France. 1088.Creatine Magnetization Transfer Effect Studied by CW Off Resonance Irradiation in Human Skeletal Muscle Adrianus Van Den Bergh1, Klaasjan Renema1, Dennis Klomp1, Arend Heerschap1 1University Hospital Nijmegen, Nijmegen, Netherlands. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) RF Coils & Analysis Forth Monday: 14:00 - 16:00 Chairs: Harald H. Quick Peter Styles 14:00 1089.A Multi-nuclear Body Coil Incorporating a Standard Proton Body Coil D.J. Herlihy1, Joseph Hajnal1 1Hammersmith Hospital, London, England, UK. 14:10 1090.A Comparison of 1, 4 and 8 Channel Phased Array Head Coils at 1.5T Scott King1, G. Randy Duensing1, Dave Peterson1, Steve Varosi1, David A. Molyneaux1 1MRI Devices Corporation, Gainesville, FL, USA. 14:20 1091.Theoretical and Experimental Evaluation of Detached Endcaps for Birdcage Coils M. Alecci1, J. L. Wilson1, P. Jezzard1, W. Liu2, C. M. Collins2, M. B. Smith2 1University of Oxford, Oxford, UK; 2Pennsylvania State University, Hershey, PA, USA. 14:30 1092.A Low-Pass Trombone Birdcage Coil with Broad Tuning Range Mary P McDougall1, David G. Brown1, Dan Spence1, Steven M. Wright1 1Texas A&M University, College Station, TX, USA. 14:40 1093.Actively Tuned Dual RF Resonator System for Functional MRI of Small Animals Gene Bogdanov1, Gerd Kueppers1, Jean A. King2, Craig F. Ferris2 1Worcester Polytechnic Institute, Worcester, MA, USA; 2University of Massachusetts Medical School (Worcester), Worcester, MA, USA. 14:50 1094.In Vivo Mapping of B1 Uniformity Produced by a Whole Body 3T RF Coil David Alsop1, Ronald Dean Watkins2, Robert Greenman1, John Schenck2, Robert Lenkinski1 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 2G.E. Corporate R & D Center, Niskayuna, NY, USA. 15:00 1095.A Shielded Single Element TEM Resonator: A Simple Extremity RF Coil for UHFMRI Pierre-Marie L. Robitaille1, Amir Abduljalil1, Tamer Ibrahim1, Brian Baertlein1, Robert Lee1, Carol J. Ashman1 1Ohio State University, Columbus, OH, USA. 15:10 1096.Manipulation of Signal Intensity Distribution with Dielectric Loading at 7.0T Qing X. Yang1, Michael B. Smith1, Haiying Liu2, Xiaoliang Zhang2, Jinghua Wang1, Kamil Ugurbil2, Wei Chen2 1Pennsylvania State University, Hershey, PA, USA; 2University of Minnesota, Minneapolis, MN, USA. 15:20 1097.A Half-Volume Transmit/ Receive Coil Combination for 7 Tesla Applications Gregor Adriany1, Josef Pfeuffer1, Essa Yacoub1, Pierre-Francois Van De Moortele1, Amir Shmuel1, Peter Andersen1, Xiaoping Hu1, John Thomas Vaughan1, Kamil Ugurbil1 1University of Minnesota, Minneapolis, MN, USA. 15:30 1098.A 3T Four Channel Preamplifier Decoupled Occipital Brain Array Patrick Ledden1, Lawrence Wald2 1Nova Medical, Inc., Wakefield, MA, USA; 2Massachusetts General Hospital, Charlestown, MA, USA. 15:40 1099.A Verification of Reciprocity for High-Field Systems: Agreement between Theory and Experiment in a Head-sized Spherical Phantom Excited with a Surface Coil at 300 MHz Christopher Collins1, Qing Yang1, Jinghua Wang1, X. Zhang, Haiying Liu2, S. Michaeli, Xiao-Hong Zhu2, Gregor Adriany2, J. Thomas Vaughan2, Peter Anderson2, Hellmut Merkle2, Kamil Ugurbil2, Michael Smith1, Wei Chen2 1Pennsylvania State University, Hershey, PA, USA; 2University of Minnesota, Minneapolis, MN, USA. 15:50 1100.Preliminary Evaluation of the Application of High Permeability Microstructured Material ((SM) in MRI Michael CK Wiltshire1, John B Pendry2, Ian R Young3, David J Larkman3, David J Gilderdale3, Joseph V Hajnal3 1Marconi Materials Technology, Towcester, Northamptonshire, England, UK; 2Imperial College, London, UK; 3Hammersmith Hospital, London, England, UK. RF Coils Hall 4 Tuesday: 13:30 - 15:30 1101.Automatic Tuned MRI RF Coil for Multinuclear Imaging at 3T Gultekin Gulsen1, Lutfi Muftuler1, Kumsal Sezen1, Orhan Nalcioglu1 1Health Sciences, Research Imaging Center, Irvine, CA, USA. 1102.Elliptical 23Na Body Resonator Florian Odoj1, A. Weisser2, Axel Haase1 1University of Würzburg, Würzburg, Germany; 2RAPID Biomedical GmbH, Wurzburg, Germany. 1103.A New RF Volume Coil for Human MR Imaging and Spectroscopy at 4 Tesla Xiaoliang Zhang1, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA. 1104.Microstrip RF Surface Coils for Human MRI Studies at 7 Tesla Xiaoliang Zhang1, Kamil Ugurbil1, Wei Chen1 1University of Minnesota Medical School, Minneapolis, MN, USA. 1105.Optimized Coil Design for Localized 19F MRS of 5FU in Liver Metastases at 1.5Tesla D. Klomp1, Hanneke Van Laarhoven2, Y. J. Kamm3, Adrianus Van Den Bergh4, D. Wagener1, Arend Heerschap4 1University Medical Center, Nijmegen, Netherlands; 2University Medical Centre St. Radboud, Nijmegen, Netherlands; 3Rhenen, Netherlands; 4University Hospital Nijmegen, Nijmegen, Netherlands. 1106.Double Tuned Coil for Interleaved 31P/19F MRS of Mouse Tumors at 7 Tesla G. Muda1, Hanneke Van Laarhoven2, D. Klomp3, Jeroen Pikkemaat1, J. Van Asten1, Y. J. Kamm4, Arend Heerschap3 1University Medical Center, Nijmegen, Netherlands; 2University Medical Centre St. Radboud, Nijmegen, Netherlands; 3University Hospital Nijmegen, Nijmegan, Netherlands; 4Rhenen, Netherlands. 1107.An Optimized Toroid-Coil for Cooled-Copper-Applications M. Blaimer1, Titus Lanz1, A. Haase1, M. Griswold1 1Universität Würzburg, Würzburg, Germany. 1108.Multiple-Mouse MRI Nicholas A. Bock1, Norman Konyer1, R. Mark Henkelman1 1University of Toronto, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada. 1109.A Hybrid Half-Volume Coil for Rabbit Brain Imaging Huiming Zhang1, Alice Wyrwicz1 1ENH Research Institute, Evanston, IL, USA. 1110.A Cosine Wire Coil Based on Litz Concept Baiyu Tang1, Linda Ann Jelicks1 1Yeshiva University, Albert Einstein College of Medicine, Bronx, NY, USA. 1111.Phased Array Imaging on Small Animal Research Systems Barbara L. Beck1, Benjamin A. Inglis1, Stephen J. Blackband1 1University of Florida, Gainesville, FL, USA. 1112.Petal Resonator Surface Coil S Hidalgo1, A O Rodriguez2, R Rojas3, J Sanchez3, G Reynoso3, F Barrios4 1IF-UNAM, Ciudad Universitaria, Mexico, D.F. Mexico; 2UAM-Iztapalapa, Mexico, D.F. Mexico; 3ABC Hospital, Mexico, D.F. Mexico; 4CNB-UNAM, Queretaro, Queretaro Mexico. 1113.Superconducting MR Helmholtz Coil Pair for Human Imaging with Improved Penetration Erzhen Gao1, KC Chan1, MS Chow1, KK Wong1, B Yan1, J Fang1, EX Wu2, D Kacher3, G Young3, F A Jolesz3, Qy Ma1, ES Yang1 1The University of Hong Kong, Hong Kong, China; 2Columbia University, New York, NY, USA; 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 1114.Transceive Quadrature Breast Coils and Applications at 4 Tesla Hellmut Merkle1, Lance DelaBarre1, Patrick J. Bolan1, Eva H. Baker1, Lenore I. Everson1, Douglas Yee1, Michael Garwood1 1University of Minnesota, Minneapolis, MN, USA. 1115.Asymmetric MRI RF Coil Desmond Yau1, Ben Gerard Lawrence1, Stuart Crozier1 1University of Queensland, Brisbane, Queensland Australia. 1116.A Whole Body Transmit Coil and Head Receive Coil Configuration for fMRI at 3T A. J. Freeman1, M. Burl2, A. M. Howseman1 1Marconi Medical Systems, Farnham, Surrey, UK; 2Marconi Medical Systems, Cleveland, OH, USA. RF Coil Evaluation and Comparison Hall 4 Tuesday: 13:30 - 15:30 1117.Four Channel Preamplifier Decoupled Phased Array for Brain Imaging at 1.5T Patrick Ledden1, Souheil Inati2 1Nova Medical, Inc., Wakefield, MA, USA; 2Dartmouth College, Hanover, NH, USA. 1118.Hybrid Phased Array Receiver Coil for 3.0T MR Imaging of Internal Auditory Canal Armen Kocharian1, Joel P. Felmlee1, John I. Lane1, Matt A. Bernstein1 1Mayo Clinic, Rochester, MN, USA. 1119.Direct Comparison of Transmit Efficiency in Bird-Cage and TEM Resonators James Tropp1, Paul Calderon1 1G. E. Medical Systems, Fremont, CA, USA. 1120.Constructions and Tests of Seven Small Bore Coil Cores for NMRI at 9.4T Baiyu Tang1, Linda Ann Jelicks1 1Yeshiva University, Albert Einstein College of Medicine, Bronx, NY, USA. 1121.Efficiency and Dielectric Resonance Effects of a Body Resonator at 175MHz Jan den Hollander1, Edward G Walsh1, Michael Vaughn1, Steven Buchthal1, Gerald M Pohost1 1University of Alabama at Birmingham, Birmingham, AL, USA. 1122.Gaining Space with an Embedded Rf Body Coil Shield Ed B. Boskamp1, Richard A. Mallozzi2, Qin Liu1, William A. Edelstein2 1GE Medical Systems, Milwaukee, WI, USA; 2GE Corporate R&D, Schenectady, NY, USA. 1123.Whole Body RF Coil for 3 Tesla MRI System Ronald D Watkins1, John F Schenck1, Kenneth W. Rohling1, Joseph Piel1, Daniel Rosenfeld2, Douglas Kelley3, Robert Lenkinski4, Herbert Kressel4, Avram Montag2 1G.E. Research & Development, Niskayuna, NY, USA; 2G. E. Medical Systems, Tirat Carmel, Israel; 3Harvard University, Wilmington, MA, USA; 4Beth Israel Deaconess Medical Center, Boston, MA, USA. 1124.High Temperature Superconducting Surface Coils for 2 Tesla Magnetic Resonance Imaging of Spinal Cord; Comparison with Implanted Coils Jaroslaw Wosik1, Lei-Ming Xie1, Feinian Wang1, Krzysztof Nesteruk2, Mehmet Bilgen3, Ponnada Aswadha Narayana3 1University of Houston, Houston, TX, USA; 2Institute of Physics of Polish Academy of Sciences, Warsaw, Poland; 3University of Texas - Houston Health Science Center, Houston, TX, USA. 1125.An Evaluation of SNR Profiles along the Coil Axis of Shaped Circular and Square Surface Coils Thomas Prock1, David Collins1, Andreas Degenhard1, Martin Leach1 1Royal Marsden Hospital, Sutton, Surrey, England, UK. 1126.Resonance Mode Selection for Inductively-Coupled Implanted Coils Thomas H. Mareci1, Xeve Silver1, Barbara Beck1 1University of Florida, Gainesville, FL, USA. RF Circuits Hall 4 Tuesday: 13:30 - 15:30 1127.Switchable Field of View RF Body Coil Ed Boskamp1, Daniel Weyers1 1G. E. Medical Systems, Milwaukee, WI, USA. 1128.Field Analysis in Crossed Birdcage Coils A. Weisser1, Titus Lanz2, Axel Haase2 1RAPID Biomedical GmbH, Wurzburg, Germany; 2Universität Würzburg, Würzburg, Germany. 1129.A Model for Image Shading in Multi-mode Resonators James Tropp1 1G. E. Medical Systems, Fremont, CA, USA. 1130.Simulation of a “Spiral” Volume Coil at High Static Magnetic Field Strength Wanzhan Liu1, Christopher M. Collins1, Michael B. Smith1 1Penn State College of Medicine, Hershey, PA, USA. 1131.A Transmission Line Model for TEM Resonators and its Comparison with Standard Electric Equivalent Circuit Models Gene Bogdanov1, Gerd Kueppers1, Reinhold Ludwig1, Jean A. King2 1Worcester Polytechnic Institute, Worcester, MA, USA; 2University of Massachusetts Medical School (Worcester), Worcester, MA, USA. 1132.Interactions and SNR in Medial-Lateral Breast Arrays Elizabeth Ramsay1, Jonathan Bishop2, Donald Plewes1 1University of Toronto, Sunnybrook & WCHSC, Toronto, ON, Canada; 2University of Toronto, Toronto, ON, Canada. RF Modeling Hall 4 Tuesday: 13:30 - 15:30 1133.New Decoupling Method for Spiral Phased Array HTS coil Jing Fang1, G G Shen1, K C Chan1, E Gao1, Q Y Ma1, E S Yang1 1The University of Hong Kong, Hong Kong, HKSAR;. 1134.Characterisation and Reduction of Eddy Currents in a TEM Resonator Marcello Alecci1, Peter Jezzard1 1University of Oxford, John Radcliffe Hospital, Oxford, UK. 1135.Circuit Resistance and Rational Matching for the TEM Resonator James Tropp1 1G. E. Medical Systems, Berkeley, CA, USA. 1136.A New High Field RF Resonator - Design and Simulations Titus Lanz1, Mark Griswold1, Axel Haase1 1Universität Würzburg, Würzburg, Germany. 1137.The Use of Circularly Polarized Coils with a Low Input Impedance Preamplifier Uli Gotshal1, G. Randy Duensing1 1MRI Devices Corporation, Gainesville, FL, USA. Gradient Coils Hall 4 Tuesday: 13:30 - 15:30 1138.Distributed Gradient Coil Design Using Linear Programming Wenyan He1, Patrick N. Morgan1 1Texas A&M University, College Station, TX, USA. 1139.A Variation on Variational Methods: Disk Gradient Example Sh. Shvartsman1, R. Brown2, Y.-C. Cheng2, T. Eagan2, J. Willig2 1Marconi Medical Systems, Inc., Highland Hts, OH, USA; 2Case Western Reserve University, Cleveland, OH, USA. 1140.New Type of Head-Only Gradient Coil with Strong and Linear Gradient Field for Head MR Imaging Y. J. Yang1, C. H. Oh1, K. K. Park1, J. H. Hyun1, D. R. Lee1 1Korea University, Seoul, South Korea. 1141.Asymmetrical-Gradient Coil for Head Imaging Dardo Tomasi1, Elisabeth Caparelli1, Bernd Foester2, Horacio Panepucci2, Alberto Tannus2, Edson Vidoto2, Rogerio Xavier2 1Universidad Nacional de General San Martín, Buenos Aires, Argentina; 2Universidade de Sao Paulo, Sao Paulo, Brazil. 1142.Development of Multi-channel Gradient Probe for Super-Parallel MR Microscope Yoshimasa Matsuda1, Tomoyuki Haishi1, Yukako Yamazaki1, Katsumi Kose1, Izumi Anno1 1University of Tsukuba, Tsukuba, Ibaraki Japan. 1143.Limits on Shielding for MRI Coils T. Eagan1, R. Brown1, H. Mathur1, R. Petschek1, Shmaryu Shvartsman2, J. Willig1 1Case Western Reserve University, Cleveland, OH, USA; 2Marconi Medical Systems, Inc., Cleveland, OH, USA. New Scanner Designs Hall 4 Wednesday: 13:30 - 15:30 1144.Open Vertical Mobile 0.22T MRI System for Veterinary/Human Extremities Imaging KC Chan1, SM Yeung1, KK Wong1, CT Leung1, EX Wu2, QY Ma1, GX Shen1, ZR Dong3, KH Lam4, K L Watkins4, ES Yang1 1The University of Hong Kong, Hong Kong, China; 2Columbia University, New York, NY, USA; 3Chinese Academic of Science, China; 4Equine Hospital, The Hong Kong Jockey Club, Hong Kong, China. 1145.Development of Desktop MR Microscopes Using 1.0 T Dipole-Ring Permanent Magnets Tomoyuki Haishi1, Yoshimasa Matsuda1, Yukako Yamazaki1, Katsumi Kose1, Shin Utsuzawa2, Akio Nakanishi3, Shigemasu Okada3, Tsuyoshi Tsuzaki3 1University of Tsukuba, Tsukuba, Japan; 2MR Technology, Inc., Tsukuba, Japan; 3Sumitomo Special Metals Co., Ltd, Mishima, Osaka Japan. 1146.Blueprint for a 21st Century MR Research Console - Integration of Simulation with software-based Pulse Programming Jonathan C. Sharp1, Donghui Yin1, Peter Latta2, Vladimir Jellus2, John Rendell1 1National Research Council, Winnipeg, Manitoba, Canada; 2Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia. 1147.An Inexpensive 0.2T Desktop MR Scanner David G. Brown1, David C. Spence1, Steven M. Wright1, Jay R. Porter1 1Texas A&M University, College Station, TX USA. B0 Magnet Design Hall 4 Wednesday: 13:30 - 15:30 1148.Novel Short Whole Body MRI Magnet Design using Genetic Algorithms Nicholas. R. Shaw1, R. E. Ansorge1, Moray. B. Grieve1, T. Adrian. Carpenter1, Laurie. D. Hall1 1University of Cambridge, Cambridge, Cambs, UK. 1149.Short Magnets for Whole-Body Magnetic Resonance Imaging Frank Davies1, Gordon DeMeester2, David Melotte1, Michael Morich2, Adrian Thomas1 1Oxford Magnet Technology Ltd, Oxford, Oxon, England, UK; 2Marconi Medical Systems, Highland Heights, OH, USA 1150.High Efficiency Open Mono-Planar Quadru-Ferro-Refraction MRI Magnet Yuly M. Pulyer1, Mirko I. Hrovat2 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 2Mirtech, Inc., Brockton, MA, USA. System Electronics Hall 4 Wednesday: 13:30 - 15:30 1151.Engineering Design of Phased Array EPI using TDM G.X. Shen1 1University of Hong Kong, Pokfulam, Hong Kong, China. 1152.A Fast Recovery Pulsed Readout Power Supply for Prepolarized MRI Nathaniel Matter1, Steven Conolly1, Albert Macovski1, Greig Scott1 1Stanford University, Stanford, CA, USA. 1153.A Coil Independent Two-Way Visualisation Device for Patient Anxiety Reduction and Presentation of Visual Stimuli Maarten van der Kamp1, Elizabeth van Vorstenbosch-Lynn1, Hans Vrijheid1 1Philips Medical Systems Nederland, Best, Netherlands. 1154.Hardware for Performing Hyperpolarized Helium Imaging on a Clinical MR Imager Angela Tooker1, Adelaide Zhang2, Arvind Venkatesh3, Kwan Soo Hong2, Mitchell Albert2 1Massachusetts Institute of Technology, Cambridge, MA, USA; 2Brigham & Women's Hospital, Boston, MA, USA; 3Boston University, Boston, MA, USA. 1155.Development and Building of a Simple, Accurate and Low Cost RF Noise Figure Meter Silvia Amanda Cenzano1 1National Research Council, Winnipeg, MB, Canada. Shims Hall 4 Thursday: 13:30 - 15:30 1156.Linear Programming-Based Shim Design for Prepolarized MRI Sharon Ella Ungersma1, Albert Macovski1, G. C. Scott1, Steven Conolly1 1Stanford University, Stanford, CA, USA. 1157.Improved Shim by Subject Head Positioning Keith Heberlein1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. System Calibration Hall 4 Thursday: 13:30 - 15:30 1158.The Significance of the Signal-to-Noise Ratio in Type Testing and Acceptance Testing for 26 MRI Scanners Janet De Wilde1, David Price1, A. Papadaki1, J. Curran1, R. I. Kitney1 1Imperial College, London, England, UK. 1159.A Method for Calibrating Inter-subsystem Hardware Delays on an MRI Machine Michael Thompson1, Wayne Dannels1 1Marconi Medical Systems, Cleveland, OH, USA. 1160.Interactive Adjustment of Gradient Shims and Saturation Parameters Using Real-time Imaging Michael A. Guttman1, Elliot R. McVeigh1 1National Institutes of Health, Bethesda, MD, USA. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) fMRI: Signal Modeling and New Techniques Clyde Auditorium Tuesday: 13:30 - 15:30 Chairs: Richard B. Buxton Robert Turner 13:30 1161.Does the Early-Negative BOLD Arise from a Delayed CBF Response? Timothy Duong1, Noam Harel1, Seong-Gi Kim1 1University of Minnesota, Minneapolis, MN, USA. 13:40 1162.Close Tag, Short TR Continuous ASL for Functional Brain Mapping: High Temporal Resolution ASL with a BOLD Sized Signal at 1.5T Eric Wong1, Thomas Liu1, Lawrence Frank2, Richard Buxton1 1University of California, San Diego, La Jolla, CA, USA; 2University of California, San Diego, VA Medical Center, San Diego, CA, USA. 13:50 1163.Event-related Perfusion Measurement using TILT and Balloon-Model Description of the Hemodynamic Response to Short Stimuli Conny F. Schmidt1, Gerard Crelier2, Ulrike Dydak1, Peter Boesiger1 1University and ETH Zurich, Zurich, Switzerland; 2University Hospital Zürich, Zürich, Switzerland. 14:00 1164.Nonlinearity of the Hemodynamic Response: Modeling the Neural and BOLD Contributions Richard Buxton1, Thomas Liu2, Eric Wong2 1University of California, San Diego, San Diego, CA, USA; 2University of California, San Diego, Thornton Hospital, La Jolla, CA, USA. 14:10 1165.Linearity of the BOLD Response to Varying Durations of Stimulus "OFF" Periods Rasmus Birn1, Peter Bandettini1 1National Institute of Mental Health, Bethesda, MD, USA. 14:20 1166.MRI Functional Connectivity To Distinguish Primary and Secondary Pathways Victoria Morgan1, Ronald R. Price1 1Vanderbilt University, Nashville, TN, USA. 14:30 1167.Detection of Latency of Neural Activity Between Visual Areas: An Event-Related fMRI Study Jiancheng Zhuang1, Sheng He1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 14:40 1168.Correlating BOLD Contrast with Simultaneous NIRS using the Valsalva Maneuver Bradley J. MacIntosh1, Ravi S. Menon2 1University of Western Ontario, London, ON, Canada; 2The John P. Robarts Research Institute, London, ON, Canada. 14:50 1169.Flow-sensitive Alternating Diffusion-weighting Effect(FADE): A Direct Method to Distinguish Vascular and Parenchymal Contributions to Brain fMRI Signal A.W Song1, M. Woldorff1, H. Fichtenholtz1, George R. Mangun1, Gregory McCarthy1 1Duke University, Durham, NC, USA. 15:00 1170.IRIS: A Novel Technique for Multi-Contrast fMRI Song Lai1, J.J. Wang1, G.H. Jahng1, R. Benson1, G.R. Ramsby1 1University of Connecticut School of Medicine, Farmington, CT, USA. 15:10 1171.Combined Single Shot Perfusion and BOLD Imaging Peter Van Gelderen1, Martin Yongbi1, Jeff Duyn1 1National Institutes of Health, Bethesda, MD, USA. 15:20 1172.Contrast Enhancements in MRI and fMRI by Sensitivity-Improved Detection of Intermolecular Zero- and Double-Quantum Coherences Yung-Ya Lin1, Hannah H. C. Chang1, Warren S. Warren1 1Princeton University, Princeton, NJ, USA. fMRI: Numerical Modeling Hall 4 Monday: 14:00 - 16:00 1173.Field Strength Dependence of Extravascular Contribution of BOLD Signal Changes: A Simulation with a Vascular Network Model Norihiko Fujita1 1Osaka University Medical School, Suita, Japan. 1174.The Effect of Finite Length of Blood Vessels on the MR Signal in BOLD Imaging Dmitriy Yablonskiy1, Alexander Sukstanskii1 1Washington University, St. Louis, MO, USA. 1175.Additional Gradients and Large Vessel Contributions in fMRI: A Modeling Approach Vincent Denolin1, Thierry Metens2 1Université Libre de Bruxelles, Brussels, Belgium; 2Université Libre de Bruxelles, Hôpital Erasme, Brussels, Belgium, 1176.Heterogeneity of TE Response Curves using Cubic mm Voxels Bharat Biswal1, Andrzej Jesmanowicz1, James Hyde1 1Medical College of Wisconsin, Milwaukee, WI, USA. 1177.An Analytic Solution of the Density of States of a Magnetic Sphere Yu-Chung Cheng1, E. Mark Haacke2 1Case Western Reserve University, St Louis, MO, USA; 2The MRI Institute for Biomedical Research, St. Louis, MO, USA. 1178.Influence of Haemoglobin and Haematocrit on BOLD fMRI Signal Intensity at 3 Tesla Sharon Gustard1, Emma J. Williams1, Laurance D. Hall1, T. Adrian Carpenter1 1University of Cambridge, Cambridge, England, UK. 1179.Comparison of the BOLD Signal Change in Event-Related fMRI with Computer Simulations Using the Balloon Model Ching-Mei Feng1, Ho-Ling Liu2, Jia-Hong Gao1 1University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 2Chang Gung University, Chang Gung Medical Center, Taoyuan, Taiwan. 1180.Coupling Between the Overshoots in BOLD Signal and Blood Flow Changes: A Computer Simulation Based on Balloon Model Ching-Mei Feng1, Ho-Ling Liu2, Jia-Hong Gao1 1University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 2Chang Gung University, Chang Gung Medical Center, Taoyuan, Taiwan, ROC. fMRI: Signal Characteristics Hall 4 Monday: 14:00 - 16:00 1181.Relationship between S/N and fMRI Sensitivity Natalia Petridou1, Frank Ye1, Alan McLaughlin1, Peter Anthony Bandettini1 1National Institutes of Health, Bethesda, MD, USA. 1182.The Intercept Value in the Linear Relationship Between Fractional Signal Changes and Echo Time in fMRI Patrick Stroman1, Vicky Krause1, Uta Frankenstein1 Krisztina Malisza1, Boguslaw Tomanek1 1National Research Council-Canada, Winnipeg, MB, Canada. 1183.T2 Weighted fMRI in Humans at High Magnetic Fields Essa Yacoub1, Timothy Duong1, Gregor Adriany1, Seong-Gi Kim1, Kamil Ugurbil1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 1184.Identification of T1 Values for Brain Activated Pixels from Transient fMRI Data Sets Y. Mazaheri1, Bharat Biswal1, Andrzej Jesmanowicz1, James Hyde1 1Medical College of Wisconsin, Madison, WI, USA. 1185.T2* Variability Across Brain Regions is Similar at 3.0T and 1.5T: Implications for BOLD fMRI Michael Lipton1, Gaby Pell1, Craig Branch1, Jan Hrabe2, D. P. Lewis3, Joseph A. Helpern4 1Nathan Kline Institute, Orangeburg, NY USA; 2Yeshiva University, Orangeburg, NY, USA; 3Albert Einstein College of Medicine, Bronx, NY, USA; 4New York University, New York, NY, USA. 1186.Differential fMRI BOLD Response to Breathold in Humans and Anesthetized Rats Sridhar Kannurpatti1, Bharat Biswal1 1Medical College of Wisconsin, Milwaukee, WI, USA. 1187.Separation of BOLD Contribution Related to Dynamic Dephasing Regime in Water and Metabolites of Human Visual Cortex at 7T: A Comparison Study Using Carr-Purcell and Hahn Spin Echo MRS Shalom Michaeli1, Michael Garwood1, Xiao-Hong Zhu1, Lance DelaBarre1, Kamil Ugurbil1, Wei Chen1 1University of Minnesota School of Medicine, Minneapolis, MN, USA. 1188.Probing of Static and Dynamic BOLD Effect and Non-BOLD Effect of Cerebral Metabolites by Functional MRS in Human Visual Cortex at 4T and 7T Shalom Michaeli1, Xiao-Hong Zhu1, Michael Garwood1, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA. 1189.Examination of the Linearity of BOLD fMRI Responses in a Higher Level Cognitive System Kaundinya Gopinath1, Richard W. Briggs1, Nathan Himes1 1University of Florida, Gainesville, FL, USA. 1190.Estimation of Relative Oxidative Metabolic Changes during Motor Activity using Graded Hypercapnic Calibration at 4 Tesla Eric Ray Cohen1, Kamil Ugurbil2, Seong-Gi Kim2 1SUNY Upstate Medical University, Syracuse, NY and University of Minnesota, Minneapolis, MN, USA; 2University of Minnesota, Minneapolis, MN, USA. 1191.Transient Decrease in Water Diffusion Observed in Human Occipital Cortex During Visual Stimulation Anne Darquie1, Jean-Baptiste Poline1, Herve Saint-Jalmes2, Denis Le Bihan1 1CEA-Service Hospitalier Frédéric Joliot, Orsay, France; 2Université Claude Bernard-Lyon I, Villeurbanne, France. 1192.Why does MTR Change with Neuronal Depolarization? Greg J Stanisz1, Richard Yoon2, Michael Joy2, R. Mark Henkelman1 1University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2University of Toronto, Toronto, ON, Canada. 1193.Does Age influence the BOLD Response? Gregory S Harrington1, Traci H Downs2, Dennis R Proffitt2, Carol A Manning2, J Hunter Downs III2 1University of California at Davis, Sacramento, CA, USA; 2University of Virginia, Charlottesville, VA, USA. 1194.Dependence of Functional Connectivity on Functional State of the Brain Victoria Morgan1, Ronald R. Price1 1Vanderbilt University, Nashville, TN, USA. 1195.Comparison of the Intravascular Dependence of R2 and R2* in Blood on Oxygenation at 1.5 T M. Johanna Silvennoinen1, Chekesha Clingman2, Xavier Golay2, Risto Kauppinen1, Peter C. Van Zijl2 1University of Kuopio, Kuopio, Finland; 2Johns Hopkins University, Baltimore, MD, USA. 1196.Magnetic Susceptibility of Human Blood Dmitriy Yablonskiy1, William M. Spees1, Joseph J.H. Ackerman1 1Washington University, St. Louis, MO, USA. 1197.Hyperventilation Strongly Reduces BOLD Contrast in Motor, Visual and Auditory Cortices Navid Seraji-Bozorgzad1, Gregory J. Moore, Manuel E. Tancer, Stephen R. Dager2, Stefan Posse 1Wayne State University, University Health Center, Detroit, MI, USA; 2University of Washington School of Medicine, Seattle, WA, USA. 1198.Predicting BOLD Signal Changes as a Function of Resolution Yu-Chung Cheng1, E. Mark Haacke2, Gwenael Herigault2 1Case Western Reserve University, The MRI Institute for Biomedical Research, St Louis, MO, USA; 2The MRI Institute for Biomedical Research, St. Louis, MO, USA. fMRI: Signal Instabilities Hall 4 Monday: 14:00 - 16:00 1199.A Quantitative Comparison of Motion Detection Algorithms in fMRI Babak Ardekani1, A. H. Bachman2, Joseph A. Helpern3 1The Nathan S. Kline Institute, New York University Medical School, Orangeburg, NY, USA; 2Nathan S. Kline Institute, Orangeburg, NY, USA; 3New York University, New York, NY, USA. 1200.Motion Parameters in fMRI time Series Data as Determined by Retrospective Motion Correction using Map-Slice-To-Volume Approach Boklye Kim1, Thomas L. Chenevert1, Charles R. Meyer1 1University of Michigan, Ann Arbor, MI, USA. 1201.Feature Based Image Registration for FMR Images Kaundinya Gopinath1, Yunmei Chen1, Richard W. Briggs1, Feng Huang1, T Sheshadri1 1University of Florida, Gainesville, FL, USA. 1202.Resampling Methods to Test Reliability of Motion-Corrected fMRI Data Ranjan Maitra1, Steven R Roys1, Joel Greenspan1, Rao P Gullapalli1 1University of Maryland Baltimore County, Baltimore, MD, USA. 1203.Experimental Determination of Accuracy in Image-Based Motion Detection for fMRI Stefan Thesen1, Lothar R. Schad2, André Bongers2, Edgar Mueller1 1Siemens Medical Systems, Erlangen, Germany; 2Deutsches Krebsforschungszentrum, Heidelberg, Germany. 1204.Coupling Effect of Cardiac Pulsation with Hemodynamic Changes Toru Yamamoto1, Shing-Chung Ngan2, Yoshifumi Yamada, Mamoru Tamura1 1Hokkaido University, Sapporo, Japan; 2University of Minnesota, Minneapolis, MN, USA. 1205.Estimation of the Physiological to System Noise Ratio in the Human Brain K. Arfanakis1, D. Cordes1, V. M. Haughton1, M. E. Meyerand1 1University of Wisconsin, Madison, WI, USA. 1206.Stimulus-Induced Ventilation Artifact in fMRI: A Case Report Cathy Nangini1, W. R. Staines2, S. E. Black2, William E. McIlroy1, Simon Graham2 1University of Toronto, Toronto, ON, Canada; 2Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, ON, Canada. 1207.The Interplay between Motion Correction and Slice Timing Correction in fMRI Data Processing Wing-Ki Wilkin Chau1, Simon Graham2, A. R. McIntosh1 1University of Toronto, Toronto, ON, Canada; 2University of Toronto, Sunnybrook Health Science Centre, Toronto, ON, Canada. 1208.Adaptive Signal-Preserving Denoising of ER-fMRI Data Using Spectrum Subtraction Yasser Kadah1 1Cairo Univeristy, Giza, Egypt. 1209.Increased Detection Sensitivity in fMRI by Adaptive Filtering Ola Friman1, Peter Lundberg1, Magnus Borga1, Jonny Cedefamn1, Hans Knutsson1 1Linköping University, Linköping, Sweden. 1210.Estimation and Correction for 0.1 Hz Fluctuations in fMRI Based on Frequency Selective Phase Correlated Spatial Averaging Shantanu Sarkar1, Pierre-Francois Van De Moortele1, Shing-Chung Ngan1, Essa Yacoub1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. fMRI Acquisition Techniques Hall 4 Tuesday: 13:30 - 15:30 1211.Measuring Regional Cerebral Blood Flow Changes in Brain Activation by Suppressing Stationary Signal Using Triple Inversion Recovery Puneet Sharma1, W. Thomas Dixon2 1Georgia Institute of Technology, Atlanta, GA, USA; 2Emory University, School of Medicine Atlanta, GA, USA. 1212.Event-Related Perfusion fMRI with Randomized Designs Thomas Liu1, Eric Wong1, Karam Sidaros2, Lawrence Frank3, Richard Buxton4 1University of California, San Diego, Thornton Hospital, La Jolla, CA, USA; 2Hvidovre Hospital, Hvidovre, Denmark; 3University of California, San Diego, VA Medical Center, San Diego, CA, USA; 4University of California, San Diego, San Diego, CA, USA. 1213.Detection of the Brain Response during a Cognitive Task using Perfusion-Based Event-Related Functional MRI Seong-Hwan Yee1, Ho-Ling Liu2, Jinwen Hou3, Yonglin Pu1, Peter T. Fox1, Jia-Hong Gao1 1University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 2Chang Gung University, Chang Gung Medical Center, Taoyuan, Taiwan; 3Shandong Medical University Hospital, Jinan China. 1214.Simultaneous BOLD/Perfusion fMRI with FAIR and UNFAIR at 1.5T and 3.0T: Optimization and Comparison Martin Yongbi1, F. Fera1, J. A. Frank1, Jeff Duyn1 1National Institutes of Health, Bethesda, MD, USA. 1215.Measurement of BOLD, rCBV, and Blood Oxygen Saturation in a Single Shot Oliver Speck1, Valerij Kiselev1, Jürgen Hennig1 1University Medical Center, Freiburg, Germany. 1216.Hypercapnia Normalization of BOLD fMRI Response during Cognitive Tasks. Richard P Kennan1, R. Todd Constable1 1Yale University, School of Medicine, New Haven, CT, USA. 1217.On the Potential of Sensitivity Encoded EPI for BOLD Functional Brain Imaging Jacco De Zwart1, Peter Kellman1, Peter Van Gelderen1, Jeff Duyn1 1National Institutes of Health, Bethesda, MD, USA. 1218.Repetition Time in Echo Planar Functional MR Imaging R. Todd Constable1, Dennis D. Spencer1 1Yale University, School of Medicine, New Haven, CT, USA. 1219.The Efficacy of Cardiac Gating with Variable TR Correction in fMRI Rasmus M. Birn1, Jerzy Bodurka1, Peter A. Bandettini1 1National Institute of Mental Health, Bethesda, MD, USA. 1220.Single-shot Multislice U-FLARE Imaging. Application to Functional MRI Wolfgang Dreher1, Elmar Busch2, Kurt Bockhorst1, Martin Meier1, Dieter Leibfritz1 1University of Bremen, Bremen, Germany; 2University of Essen, Essen, Germany. 1221.T2-Prepared BOLD fMRI Vincent Denolin1, Thierry Metens2 1Université Libre de Bruxelles, Brussels, Belgium; 2Université Libre de Bruxelles, Hôpital Erasme, Brussels, Belgium. 1222.Measuring CBF and T2* Changes in Activated Primary Visual Cortex using Saturation Recovery with Multi-echo EPI S. Francis1, P. Gowland1, R. W. Bowtell1 1University of Nottingham, Nottingham, UK. 1223.Measuring Blood Oxygenation using Variable Echo Spacing CPMG: Use of the Luz-Meiboom Equation Chris V. Bowen1, Brian K. Rutt1 1The John P. Robarts Research Institute, London, Ontario, Canada. 1224.Measuring the Timings of Motor Events in fMRI using High Speed Multi-Slice PRESTO-EPI Andrew M Gibson1, Andrew M Peters1, Peter G Morris1, Richard W Bowtell1 1University of Nottingham, Nottingham, UK. 1225.The Effects of a Change in Blood Flow When Using 3D-PRESTO for fMRI Hans Hoogduin1, Nick Ramsey1 1University Medical Center Utrecht, Utrecht, Netherlands. 1226.Speech Recording During fMRI Eric Featherstone1, O. Josephs1 1Institute of Neurology, London, UK. 1227.A New Vibrotactile Stimulation Device for fMRI Richard W. Briggs1, Iona Dy-Liacco1, Kaundinya S. Gopinath1, Nathan C. Himes1, David A. Soltysik1, Paul Browne2, Roger Tran-Son-Tay1 1University of Florida, Gainesville, FL, USA; 2Steadfast Technologies, Seffner, FL, USA. 1228.New Devices to Deliver Somatosensory Stimuli During fMRI Simon J. Graham1, W. R. Staines2, A. Nelson2, Donald Plewes1, William E. McIlroy2 1University of Toronto, Sunnybrook Health Science Centre, Toronto, ON, Canada; 2University of Toronto, Toronto, ON, Canada. fMRI Artifacts Hall 4 Tuesday: 13:30 - 15:30 1229.The Effects of Physiological Noise Correction on fMRI Time-Series William Auffermann1, Shing-Chung Ngan1, Shantanu Sarkar1, Essa Yacoub1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 1230.Fast, Fully Automated Global and Local Shimming of the Human Brain James Wilson1, Peter Jezzard1 1University of Oxford, John Radcliffe Hospital, Oxford, UK. 1231.Whole Brain fMRI with Steady State Z-Shimming At Selected Slices Yiping P. Du1 1University of Chicago, Chicago, IL, USA. 1232.Image Blurring in fMRI with Z-Shim Yiping P. Du1 1University of Chicago, Chicago, IL, USA. 1233.Reduction of Susceptibility Artifact in Human Brain with MESBAC Sequence Zhu Li1, Gaohong Wu1, Xiaoli Zhao1, Feng Luo1, Shi-Jiang Li1 1Medical College of Wisconsin, Milwaukee, WI, USA. 1234.Compensation of Susceptibility Induced BOLD Sensitivity Losses in Echo-Planar fMRI Imaging Ralf Deichmann1, Robert Turner1 1Institute of Neurology, University College London, London, UK. 1235.Reduction of Motion Artefacts using Prospective Acquisition Correction for fMRI Stefan Thesen1, Edgar Mueller1, Lothar R. Schad2 1Siemens Medical Systems, Erlangen, Germany; 2Deutsches Krebsforschungszentrum, Heidelberg, Germany. 1236.Do Different MRI Scanners Produce Different fMRI Results? Cristina Lavini1, Erik-Jan Vlieger1, Charles B. Majoie1, Gerard J. Den Heeten1 1Academic Medical Center, Amsterdam, The Netherlands. 1237.Match-Warped EPI Anatomic Images and the Amygdala: Imaging in Hard Places Michael L Rohan1, William D. S. Killgore1, Justin G Eskesen1, Perry F Renshaw1, Deborah A Yurgelun-Todd1 1McLean Hospital Brain Imaging Center, Harvard Medical School, Belmont, MA, USA. fMRI: Localization and Spatio-temporal Aspects Hall 4 Tuesday: 13:30 - 15:30 1238.Rapid Motor Preparation Revealed by FMRI W.H. Backes1, J.J. Adam2 1University Hospital Maastricht, Maastricht, Netherlands; 2Maastricht University, Maastricht, Netherlands. 1239.Functional Magnetic Resonance Imaging of Automatic and Controlled Hand Writing Peter Erhard1, Alexander Peinemann1, Claus Baumgart1, Claudia Mentschel1, Bastian Conrad1, Markus Schwaiger1, Hartwig R. Siebner2 1Technische Universität, München, Germany; 2Institute of Neurology, London, UK. 1240.Spatiotemporal Characteristics of Cerebellar BOLD Responses to a Precision Grip Task Gérard R. Crelier1, Thomas Järmann1, Hatem Alkadhi1, Xavier Golay1, Marie-Claude Hepp-Reymond1, Spyros S. Kollias1 1University Hospital Zurich, Zurich, Switzerland. 1241.Brain Activation during Precision versus Casual Handgrip Tasks Jing Z. Liu1, Yasuaki Harasaki1, Guang H. Yue1 1Cleveland Clinic Foundation, Cleveland, OH, USA. 1242.Fine-Scale Finger Somatotopy in the Human Primary Motor Cortex as Revealed by High-Resolution Functional MRI Peter Dechent1, Jens Frahm1 1Biomedizinische NMR Forschungs GmbH am MPI für biophysikalische Chemie, Göttingen, Germany. 1243.Event-Related Functional Magnetic Resonance Imaging of Sensory System by Using Cold and Touch Stimulation in Normal Volunteers In Chan Song1, Kee Hyun Chang, In Kyu Yu, Sang Hyun Lee, Moon Hee Han 1Seoul National University College of Medicine and Institute of Radiation Medicine, Seoul, Korea. 1244.The Somatosensory and Visual Cortex Roles during a Tactual Mental Imagery: An fMRI Study Severine Lambert1, Eliana Sampaio1, Christian Scheiber1, Yves Mauss1 1Université Louis Pasteur, Strasbourg, France. 1245.Somatosensory Cortical Activation in the Absence of Sensory Stimulation Sami Martinkauppi1, Hannu Aronen1, Antti Korvenoja1, Antti Pertovaara2, Synnöve Carlson3 1Helsinki University Central Hospital, Helsinki, Finland; 2University of Turku, Turku, Finland; 3University of Helsinki, Helsinki, Finland; 1246.Primary Sensorimotor Cortex is Activated by Virtual Movements: A fMRI Study in 3 Cases of Amputated Patients Danielle Ibarrola1, Franck-Emmanuel Roux2, Yves Lazorthes3, Isabelle Berry3 1Hôpital Purpan & Rangueil, Toulouse, France; 2Hôpital Purpan, Toulouse, France; 3Hôpital Rangueil, Toulouse, France. 1247.Evaluation of Cerebral Cortices Associated with Sexual Arousal in Healthy Male Using BOLD-based Functional MRI Gwang-Woo Jeong1, Heoung-Keun Kang, Jeong-Jin Seo, Hyung-Joong Kim, Kwang-Sung Park1 1Chonnam University Medical School, Kwang-Ju, S. Korea. 1248.Functional MRI of the Human Amygdala? Klaus-Dietmar Merboldt1, Peter Fransson2, Harald Bruhn1, Jens Frahm1 1Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany; 2Karolinska Institutet, Stockholm, Sweden. 1249.Nasotemporal Asymmetries of the Ocular Dominance Regions in Human Visual Cortex Demonstrated by Functional MRI Ahmed Toosy1, David Werring1, G T Plant1, Edward Bullmore2, D H Miller1, A J Thompson1 1University College London, Institute of Neurology, London, UK; 2Addenbrookes Hospital, Cambridge, UK. 1250.The Activated Areas in Binaural and Monaural Listening Comprehension: An fMRI Study Fukujiro Ozawa1, Toshiharu Nakai2, Kayako Matsuo2, Chikako Kato3, Haruo Isoda1, Yasuo Takehara1, Harumi Sakahara1 1Hamamatsu University School of Medicine, Hamamatsu, Shizuoka Japan; 2Medical Vision Lab, LERC, AIST / Kobe AMC, Ikeda, Osaka Japan; 3Toyohashi Sozo College, Toyohashi, Japan. 1251.Reproducibility of BOLD Response in the Human Brain as Measured at High-Resolution at 7 Tesla Amir Shmuel1, Essa Yacoub1, Josef Pfeuffer1, Pierre-Francois Van De Moortele1, Gregor Adriany1, Kamil Ugurbil1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 1252.Optimal Voxel Size for Detection of fMRI Activation of Visual Cortex Chia-Shang Jason Liu1, Atsushi Miki1, Grant Liu1, John Haselgrove1 1University of Pennsylvania, Philadelphia, PA, USA. 1253.Diffusion-Weighted BOLD fMRI at 4 and 7 Tesla: Evaluation of Micro- versus Macrovascular Contributions Timothy Duong1, Essa Yacoub1, Xiaoping Hu1, Gregor Adriany1, Hellmut Merkle1, Peter Andersen1, J. Thomas Vaughan1, Kamil Ugurbil1, Seong-Gi Kim1 1University of Minnesota, Minneapolis, MN, USA. 1254.fMRI with High Spectral and Spatial Resolution Echo-Planar Spectroscopic Imaging at 1.5 T Yiping P. Du1, Weiliang Du1, Stephen J. Uftring1, Xiaobing Fan1, Gregory S. Karczmar1 1University of Chicago, Chicago, IL, USA. 1255.Spin-Echo BOLD Signal Yields Improved Spatial Specificity and Resolving Power Timothy Q Duong1, Noam Harel1, Seong-Gi Kim1 1University of Minnesota, Minneapolis, MN, USA. 1256.Correlation between Functional (SNR and Activation Area Size Anja-Carina Schulte1, Oliver Speck1, Jürgen Hennig1 1University Freiburg, Freiburg, Germany; 1257.Sub-Millimeter Event-Related fMRI at High Temporal Resolution Josef Pfeuffer1, Pierre-Francois Van De Moortele1, Gregor Adriany1, Xiaoping Hu1, Kamil Ugurbil1 1University of Minnesota, Minneapolis, MN, USA. 1258.Point Spread of CBF and Early-Negative BOLD fMRI Signals at Sub-Millimeter Columnar Resolution Timothy Duong1, Dae-Shik Kim1, Seong-Gi Kim1 1University of Minnesota, Minneapolis, MN, USA. 1259.Spatiotemporal Imaging of I0 and T2* during Visual Stimulation Using Single-Shot Multi-Echo fMRI Nikolaus Weiskopf1, Uwe Klose1, Klaus Mathiak1 1University of Tuebingen, Tuebingen, Germany. 1260.A General Approach of Characterizing Temporal Properties of Single-Trial fMRI Response Yu Chen1, Shantanu Sarkar1, Shing-Chung Ngan1, Stephen Laconte1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 1261.Dynamics of the BOLD Response at Ultrahigh Fields Revealed at High Spatial and Temporal Resolutions Essa Yacoub1, Amir Shmuel1, Josef Pfeuffer1, Pierre-Francois Van De Moortele1, Gregor Adriany1, Kamil Ugurbil1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 1262.Primary Visual Cortex Activated by Visual Attention During Ultra-Short Stimulation at 1.5 T Yue Cao1, Jie Huang1 1Michigan State University, East Lansing, MI, USA. 1263.Assessment of the Ability to Detect Timing Differences between Brain Regions using fMRI Devesh Raj1, Alex A Stevens2, John C Gore1 1Yale University, New Haven, CT, USA; 2Oregon Health Sciences University, Portland, OR, USA. Novel Contrast fMRI Hall 4 Tuesday: 13:30 - 15:30 1264.Withdrawn. 1265.Novel Contrast in fMRI of Auditory Stimulation with Intermolecular Double-Quantum Coherences (iDQCs) Jianhui Zhong1, Wing-Chi Edmund Kwok1, Zhong Chen1 1University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA. 1266.Investigating the Potential of Simultaneous DT-fMRI CAM Wheeler-Kingshott1, GJM Parker1, P Boulby2, MR Symms2, DK Jones3, GJ Barker1 1Institute of Neurology, University College London, London, England, UK; 2National Society for Epilepsy, Gerrards Cross, London, England, UK; 3Institute of Psychiatry, London, England, UK. 1267.MRI-Based Method for Detection of Weak and Transient Magnetic Field Changes Jerzy Bodurka1, Natalia Petridou1, Peter Anthony Bandettini1 1National Institutes of Health, Bethesda, MD, USA. 1268.Functional MRI with a T1 Contrast Agent B. Ellen Scanley1, Richard P Kennan1, Mark Does1, John C. Gore1 1Yale University, School of Medicine, New Haven, CT, USA. fMRI: Physiological Conditions Hall 4 Wednesday: 13:30 - 15:30 1269.Correspondence Between fMRI and EEG Signal Changes as a Function of Stimulus Frequency during Visual Stimulation Manbir Singh1, Sungheon Kim1, Tae-Seong Kim1, Jeong-Won Jeong1 1University of Southern California, Los Angeles, CA, USA. 1270.Event-related fMRI with Continuous EEG: Initial Experience at 1.5T Afraim Salek-Haddadi1, Louis Lemieux1, Philip Allen2, Mark Symms1, Gareth Barker3, David R. Fish3 1University College London, Institute of Neurology, Chalfont St Peter, Buckinghamshire, UK; 2National Hospital for Neurology & Neurosurgery, London, UK; 3University College London, Institute of Neurology, London, UK. 1271.Combined Spatial and Temporal Imaging of Form Discrimination in Humans ---- A fMRI+ERP Study Hengyi Rao1, Tiangang Zhou1, Yan Zhuo1, Silu Fan1, Lin Chen1 1University of Science and Technology of China, Beijing, China. 1272.Quantitative Measurements of Cerebral Metabolic Rate of Oxygen (CMRO2) Using MRI: A Volunteer Study Hongyu An1, Weili Lin2, Azim Celik3, Yueh Z. Lee2 1Washington University, Chapel Hill, NC, USA; 2UNC-Chapel Hill, Chapel Hill, NC, USA; 3GE Medical Systems, Milwaukee, WI, USA. 1273.Olfactory fMRI using a Control Apparatus of Odorous Stimuli and Its Topological Map of EEG. Chi Woong Mun1, Won Seok Kang1, Moon Young Paik1, Hyeon Yong Lee2, Choong Ki Eun3, Soon Cheol Chung4, Byung Chan Min4, Woon Jae Shin2, Soo Yeol Lee5, Min Hyoung Cho6 1Inje University, Kimhae, Kyongnam, Korea; 2Pusan Paik Hospital, Pusan, Korea; 3Inje University, Pusan Paik Hospital, Pusan, Korea; 4Korea Research Institute of Standards & Science, Taejon, Korea; 5Department of Medical Engineering, Yongin, Kyungki, Korea; 6Graduate School of East-West Medicine Kyunghee University, Yongin, Kyongi-do, Korea. 1274.Randomized Gradient Switching during Functional Magnetic Resonance Imaging (fMRI) Elicits Hemodynamic Analogues of P50 Suppression and Mismatch Negativity in Whole-Head Magnetencephalography (MEG) Klaus Mathiak1, A. Rapp1, Tilo Kircher1, Wolfgang Grodd1, Werner Lutzenberger1, Ingo Hertrich1, H. Ackermann1 1University of Tübingen, Tübingen, Germany. 1275.Transcranial Direct Current Stimulation Modulates BOLD MRI Responses in Humans J. Baudewig1, M.A. Nitsche2, W. Paulus2, J. Frahm1 1Biomedizinische NMR Forschungs GmbH am MPI für biophysikalische Chemie, Göttingen, Germany; 2University of Göttingen, Göttingen, Germany. 1276.Transition Screen Strongly Enhances Activation in Occipital Ventral Cortex During Perception of Colored Stimuli Loys Piettre1, Michel Dojat1, Peggy Gérardin1, Christoph Segebarth1, Kenneth Knoblauch2 1Institut national de la santé et de la recherche médicale, CHU Grenoble, Grenoble, France; 2Institut national de la santé et de la recherche médicale, Lyon, France. 1277.BOLD fMRI of the Visual Cortex: Quantitative Responses Measured with a Graded Stimulus at 1.5T Feroze B Mohamed1, Scott H Faro1, Joseph I Tracy2, Alexander B. Pinus1, Dhawal Patel1 1MCP Hahnemann University, Philadelphia, PA, USA; 2Thomas Jefferson University, Philadelphia, PA, USA. 1278.When the Load Gets Too Heavy: Non-Monotonic Load-Response Characteristics of a Fronto-Parietal Working Memory Network Cynthia H.Y. Fu1, Mick J. Brammer1, Steve C.R. Williams1, Jieun Kim1, Chris Andrew1, Anthony Cleare1, Nicholas D. Walsh1, Pauline M. Williams2, Liqun Wang2, Edward Bullmore3 1Institute of Psychiatry, London, UK; 2GlaxoWellcome Research and Development, Greenford, Middlesex UK; 3Addenbrookes Hospital, University of Cambridge, Cambridge, UK. 1279.Quantitative Evaluation of Activity in the Motor Cortex during a Force-Related Grasping-Task Christina Maria Grimm1, Gerard Crelier1, Hatem Alkadhi1, Marie-Claude Hepp-Reymond2, Spyros Kollias1 1University Hospital of Zürich, Zurich, Switzerland; 2University and ETH Zurich, Zurich, Switzerland. 1280.Faster Performance on a Visuomotor Task Correlates with Decreased fMRI Activation. Michael Lee1, William Bradley1, Dar-Yeong Chen1, Peter Brotchie2 1Long Beach Memorial MRI, Long Beach, CA, USA; 2Brain Imaging Research Institute, Heidelberg West, Victoria Australia. 1281.Quantitative Relationship between BOLD Signals and Neural Activity Sang-Pil Lee1, Ping Wang1, Seiji Ogawa2, Seong-Gi Kim1 1University of Minnesota, Medical School, Minneapolis, MN, USA; 2Bell Laboratories, Murray Hill, NJ, USA. 1282.Following the Trail(s): Neural Correlates of Visuomotor Tracking and Sequencing Cynthia H.Y. Fu1, Nicholas D. Walsh1, Jieun Kim1, Mick J. Brammer1, Edward Bullmore2, Anthony Cleare1, Chris Andrew1, Annabella Di Giorgio1, Pauline M. Williams3, Liqun Wang3, Steve C.R. Williams1 1Institute of Psychiatry, London, UK; 2Addenbrookes Hospital, University of Cambridge, Cambridge, UK; 3GlaxoWellcome Research and Development, Greenford, Middlesex UK. fMRI: Cognitive Neuroscience Hall 4 Wednesday: 13:30 - 15:30 1283.Distinguishing Executive Operations from Content Representation during Working Memory Function Kathryn Moores1, Richard Clark1, Gregory Brown2, James Taylor2, Andrew Lewis1, Aina Puce3, Alexander McFarlane4 1Flinders University of South Australia, Adelaide, Australia; 2Royal Adelaide Hospital, Adelaide, Australia; 3Swinburne University of Technology, Victoria, Australia; 4Queen Elizabeth Hospital, Adelaide, Australia; 1284.Metamemory as the Source of Right Frontal Activation during Recognition? Jack Rene Foucher1, Marc-Etienne Meyer1, Delphine Pins2, Jean-Marie Danion3 1Université Louis Pasteur de Strasbourg, Strasbourg, France; 2Institute of Psychiatry, London, UK; 3Hôpitaux Universitaires, Strasbourg, France. 1285.Quantitative Imaging of Hippocampal Perfusion During A Memory Encoding Task Thomas Liu1, Craig E.L. Stark2, Eric Wong1, Richard Buxton3 1University of California, San Diego, Thornton Hospital, La Jolla, CA, USA; 2University of California, San Diego, La Jolla, CA, USA; 3University of California, San Diego, San Diego, CA, USA 1286.Age Related Changes in Fronto-Striatal Activation during Paired-Associate Learning Fernando Zelaya1, Christopher Long1, Edward Bullmore2, Steven C R Williams1, Emma Ouldred3, Christopher Andrew1, John Suckling1, Virginia Ng4, Laurence Reed1, Stephen Jackson3, James Semple5, Carol Routledge5 1Institute of Psychiatry, London, UK; 2University of Cambridge, Addenbrookes Hospital, Cambridge, UK; 3King's College London, Guy's, King's and St. Thomas' School of Medicine, London, UK; 4Maudsley Hospital, London, UK; 5Smithkline Beecham Pharmaceuticals, Cambridge, UK. 1287.Brain Activation during Extraction of Forms from Complex Figures Studied by fMRI Chikako Kato1, Kayako Matsuo2, Toshiharu Nakai2, Fukujiro Ozawa3, Yasuo Takehara3, Haruo Isoda3, Satoshi Isogai3, Tetsuo Moriya4, Harumi Sakahara3 1Toyohashi Sozo College, Toyohashi, Aichi, Japan; 2AIST, Ikeda, Osaka Japan; 3Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; 4ETL Supermolecular Division, Tsukuba, Ibaraki, Japan. 1288.Cortical Regions Involved in Navigation Arthur Wunderlich1, Georg Groen1, Matthias Riepe1, Reinhard Tomczak1, Hans-Juergen Brambs1 1Universitaet Ulm, Ulm, Germany. 1289.An Event-Related fMRI Study of Delayed Nonmatching-To-Sample Performance Greig De Zubicaray1, Katie Louise McMahon1, Stephen Wilson1, Santhi Muthiah1 1University of Queensland, Brisbane, QLD, Australia. 1290.Mathematical Ability in Children of Very Low Birthweight: A Neural Correlate E.B. Isaacs1, C.J. Edmonds1, Alan Lucas1, David Gadian2 1University College London, Institute of Child Health, London, UK; 2Institute of Child Health, Royal College of Surgeons, London, UK. 1291.Interaction of Cognitive Processing and Emotional Stimulation in fMRI Arthur Wunderlich1, Henrik Walter1, Manfred Spitzer1, Hans-Jürgen Brambs1, Susanne Erk1 1Universitaet Ulm,, Ulm, Germany. 1292.Body-Centered Spatial Representation in Parietal Eye Fields Peter Brotchie1, Michael Lee2, Dar-Yeong Chen3, William Bradley3 1Brain Imaging Research Institute, Heidelberg Weste, Victoria Australia; 2Amherst College, Long Beach Memorial MRI, Long Beach, CA, USA; 3Memorial MRI Center, Long Beach, CA, USA. 1293.Functional MRI Studies of Visual Short-Term Memory Tasks with Different Delay Intervals Sunao Iwaki1, Toshiharu Nakai1, Shigeki Tanaka2, Mitsuo Tonoike1, Yukio Miki3, Kaori Togashi3, Junji Konishi4 1Life Electronics Research Center, Ikeda, Osaka, Japan; 2Graduate School of Kyoto University, Kyoto, Japan; 3Kyoto University Hospital, Kyoto, Japan; 4Kyoto University, Kyoto, Japan. 1294.Hybrid Block/Event-Related Paradigm for fMRI of a Go/No-Go Task M.C. Goldberg1, S. Courtney2, S.H. Mostofsky1, M.T. Abrams1, S. Arnold1, W.E. Kaufmann1, M.B. Denckla1, J.J. Pekar1 1Kennedy Krieger Institute & Johns Hopkins University, Baltimore, MD, USA; 2Johns Hopkins University, Baltimore, MD, USA. 1295.Lie Detection using Functional MRI Ho-Ling Liu1, Tatia M.C. Lee2, Li Hai Tan2, Chetwyn C.H. Chan3, Ching-Mei Feng4, Jinwen Hou4, Srikanth Mahankali4, Peter T. Fox4, Jia-Hong Gao4 1Chang Gung University, Chang Gung Medical Center, Taoyuan, Taiwan; 2University of Hong Kong, Hong Kong, China; 4The Hong Kong Polytechnic University, Hong Kong, China; 4University of Texas Health Science Center, San Antonio, TX, USA. 1296.Event-related fMRI Study of the Reading of Words and of Pseudowords Monica Baciu1, Olivier David2, Mathilde Pachot-Clouard3, Serge Carbonnel1, Bernard Ans1, Christoph Segebarth3 1Université Pierre Mendès-France, Grenoble, France; 2Hôpital de la Salpêtrière, Paris, France; 3Centre Hospitalier Universitaire, Grenoble, France. 1297.Differential Activation in the Left and Right DLPFC during Word and Face Recognition Memory Tasks Dirk T. Leube1, Michael Erb2, Irina Mader2, Mathias Bartels1, Wolfgang Grodd2, Tilo T. J. Kircher1 1University Hospital of Psychiatry, Tuebingen University, Tuebingen, Germany; 2Tuebingen University, Tuebingen, Germany. 1298.Neural Pathways for Copying Ideographic Characters and Copying Syllabic Characters in the Left Hemisphere – An fMRI Study Kayako Matsuo1, Chikako Kato2, Fukujiro Ozawa3, Yasuo Takehara3, Haruo Isoda3, Satoshi Isogai3, Tetsuo Moriya1, Harumi Sakahara3, Toshiharu Nakai1 1AIST / Kobe AMC, Ikeda, Osaka, Japan; 2Toyohashi Sozo College, Toyohashi, Japan; 3Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan. 1299.fMRI Responses of Reading in Developmental Dyslexia W. Backes1, E. Vuurman2, M. Wennekes1, P. Spronk1, M. Wuisman1, R. Kleijnen2, J. Jolles2, J. van Engelshoven1 1University Hospital Maastricht, Maastricht, Netherlands; 2Maastricht University, Maastricht, Netherlands. 1300.Functional MRI of Fingerspelling in Deaf Subjects Ed Auer1, Lynne Bernstein1, Jean Moore1, Jeong-Won Jeong2, Yongxia Zhow2, Witya Sungkarat2, Manbir Singh2 1House Ear Institute, Los Angeles, CA, USA; 2University of Southern California, Los Angeles, CA, USA, 1301.Perception of Fingerspelled and Printed Alphabet in Deaf Signers: An fMRI Study Andre DuFour1, Christel Robert2, Christian Scheiber1 1Université Louis Pasteur, Strasbourg, France; 2Laboratoire de Psychologie Experimentale, Grenoble, France. 1302.Participation of the Posterior Inferior Temporal Cortex in Retrieval and Memory Encoding of Chinese Words David Yeung1, Agnes Chan2, Yu-Leung Chan2, Wu-Jing He2, M-K Lam2, Mei-chun Cheung2, C-B Chung2 1Prince of Wales Hospital, Hong Kong, China; 2Chinese University of Hong Kong, Hong Kong, China. 1303.Mapping Cortical Areas Associated with Chinese Word Processing with Functional Magnetic Resonance Imaging Lin Ma1, Yiyuan Tang2, Xuchu Weng3, Dejun Li1, Yan Wang3, Xiaoping Hu4 1PLA General Hospital, Beijing, PR China; 2Dalian University of Technology, Dalian, Liaoning, PR China; 3The Chinese Academy of Sciences, Beishatan, Beijing, PR China; 4University of Minnesota, Minneapolis, MN, USA. 1304.Withdrawn fMRI: Clinical Aspects Hall 4 Wednesday: 13:30 - 15:30 1305.Functional Magnetic Resonance Imaging of Pronation-Suppination Movements Peter Erhard1, Florian Castrop1, Markus Schwaiger1, Hans Förstl1, Thomas Jahn1 1Technische Universität München, München, Germany. 1306.Encoding of Mechanical Pain Intensity within Multiple Regions of the Posterior Parietal Operculum Eric A. Moulton1, Rao P Gullapalli1, Darren K. Emge1, Karen L. Gibbs1, Joel D. Greenspan1 1University of Maryland at Baltimore, Baltimore, MD, USA. 1307.Direct Evidence of functional Activation of Double Cortex Detected by fMRI Michela Tosetti1, Domenico Montanaro2, Paolo Bonanni1, Marco Giannelli1, Alberto Spalice3, Raffaello Canapicchi1, Renzo Guerrini4 1Stella Maris Scientific Institute, Calambrone, Pisa, Italy; 2S. Chiara Hospital, Pisa, Italy; 4University La Sapienza, Rome, Italy; 4King's College Hospital, London, UK. 1308.FMRI in Amblyopia: Initial Findings Antonio Algaze1, Cynthia Roberts1, Lawrence E. Leguire2, Petra Schmalbrock1, Gary L. Rogers2 1The Ohio State University, Columbus, OH, USA; 2Columbus Children's Hospital, OSU, Columbus, OH, USA. 1309.Simultaneous EEG and Functional MRI of Epileptic Activity: A case Report J. Baudewig1, H.-J. Bittermann2, W. Paulus2, J. Frahm1 1Biomedizinische NMR Forschungs GmbH am am MPI für biophysikalische Chemie, Göttingen, Germany; 2University of Göttingen, Göttingen, Germany. 1310.Vagus Nerve Stimulation in Patients: A BOLD fMRI Study Wen-Ching Liu1, Kristine Mosier1, Andrew Kalnin1, David Marks1 1University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA. 1311.Vagus Nerve Stimulation (VNS) Synchronized fMRI Daryl E. Bohning1, Mikhail P. Lomarev1, Stewart Denslow1, Ziad Nahas1, Ananda Shastri1, Mark Stork George1 1Medical University of South Carolina, Charleston, SC, USA. 1312.High Signal-Intensity Changes with EEG-Triggered fMRI after Interictal Activity Alexander Hoffmann1, Lorenz Jäger1, Konrad J Werhahn1, S Noachtar1, Maximilian Reiser1 1University of Munich, Klinikum Grosshadern, München, Germany. 1313.Benign Epilepsy with Centro-Temporal Spikes: Spike Triggered fMRI Evidence of a Cortical Circuit John S. Archer1, Ari Syngeniotis1, David F. Abbott1, Regula S. Briellmann1, R Mark Wellard1, Graeme D. Jackson1 1Austin and Repatriation Medical Centre, Heidelberg West, Victoria, Australia. 1314.Extensive Bilateral Motor Network Activation in Congenital Hemiparesis with Good Hand Function: a fMRI Study Martin Staudt1, Wolfgang Grodd2, Gerhard Niemann1, Christian Gerloff3, Inge Kraegeloh-Mann1 1University Children's Hospital, Tuebingen, Germany; 2Radiology Clinic, Tuebingen, Germany; 3Tuebingen University, Tuebingen, Germany. 1315.Functional MRI of Mirror Movements in Congenital Hemiparesis Martin Staudt1, Wolfgang Grodd2, Gerhard Niemann1, Christian Gerloff3, Inge Kraegeloh-Mann1 1University Children's Hospital, Tuebingen, Germany; 2University Radiology Clinic, Tuebingen, Germany; 3Tuebingen University, Tuebingen, Germany. 1316.Functional MRI Used for Presurgical Mapping of Eloquent Brain of Brain Tumor Patients and Combined with Minimal Invasive Brain Surgery Olav Haraldseth1, Geir Torheim1, Abdel Wahad Bidar1, Richard Jones2, Frank Lindset3, Gunnar Myhr1, Geirmund Unsgård4, Kjell Arne Kvistad1 1Norwegian University of Science and Technology, Trondheim, Norway; 2Université V. S. Bordeaux II, Bordeaux, France; 3SINTEF Unimed, Trondheim, Norway; 4University Hospital, Trondheim, Norway. 1317.Functional MRI Investigation of Voluntary Activation of Ineffective Cerebral Motor Areas in Short- and Long-Term Spinal Cord Injury Hui Mao1, Donald R. Humphrey1, Emily Schaeffer1 1Emory University, School of Medicine, Atlanta, GA, USA. 1318.Reorganization of Brain Activation after Spinal Cord Injury Hatem Alkadhi1, Armin Curt2, Gerard R Crelier3, Marie-Claude Hepp-Reymond4, Spyros S Kollias3 1Zurich Switzerland; 2University Hospital Balgrist, Zurich, Switzerland; 3University Hospital Zurich, Zurich, Switzerland; 4University Irchel. 1319.Association Between Visual Distortion and Activity in Migraine Patients Jie Huang1, Thomas G. Cooper1, Banu Satana1, David I. Kaufman1, Yue Cao1 1Michigan State University, East Lansing, MI, USA. 1320.Brain Functional MR Imaging During Processing of Language-related Gestures in Deaf and Hearing Subjects Norihiro Sadato1, Hiroki Yamada2, Tomohisa Okada1, Harumi Itoh2, Ken-Ichi Matsuki2, Yoshiharu Yonekura2 1National Institute for Physiological Sciences, Okazaki, Aichi, Japan; 2Fukui Medical University, Fukui Japan. 1321.Event-Related Design for Suppression of Speech-Related Artifacts: Application to fMRI in Stuttering Patients Christine M. Preibisch1, Peter Raab1, Katrin Neumann1, Harald A. Euler2, Heinrich Lanfermann1, Friedhelm Zanella1 1University Frankfurt, Frankfurt, Germany; 2University Kassel, Kassel, German. 1322.A Novel BOLD fMRI Assay of Human Central Nervous System Dopamine Function: The Effects of D-Amphetamine on Photic Activation to Blue Light Ronald L Cowan1, Blaise deBonneval Frederick1, Jonathan M Levin1, Michael L Rohan1, Rosamond A Villafuerte1, Leanne E Nassar1, Scott E Lukas1, Perry F Renshaw1 1McLean Hospital, Belmont, MA, USA. 1323.Event-related fMRI of Single Joystick Movements in Parkinson's Disease Peter Erhard1, Bernhard Haslinger1, Nina Kaempfe1, Henning Boecker1, Markus Schwaiger2, Bastian Conrad1, Andres O. Ceballos-Baumann1 1Technische Universität, München, Germany; 2Technische Universität, Klinikum Rechts der Isar, München, Germany. 1324.Dedicated MR and Optical Spectroscopy on the Neonatal Ward Martyn Paley1, Elspeth Whitby1, John Martindale1, Jason Berwick2, John Mayhew2, Mike Smith3, Paul Griffiths1 1University of Sheffield, Royal Hallamshire Hospital, Sheffield, Yorkshire, England, UK; 2University of Sheffield, Sheffield, Yorkshire, England, UK; 3University of Sheffield, Jessop Hospital for Women, Sheffield, Yorkshire England, UK. 1325.Technique to Study fMRI Changes Induced by Acupuncture over a Thirty-Minute Period: A Feasibility Study Wen-Ching Liu1, Dung-Liang Hung1, Andrew Kalnin1, Andrei I Holodny1, Barry R. Komisaruk2 1University of Medicine and Dentistry of New Jersey, Newark, NJ, USA; 2Rutgers, The State University of New Jersey, Newark, NJ, USA. 1326.Use of Functional MRI to Evaluate Correlation Between Acupoints and the Somatic Sensory Cortex Activities G Li1, KK Wong1, L Huang2, SR Liu2, G Cao3, GG Shen1, ES Yang1, QY Ma1 1The University of Hong Kong, Hong Kong, HKSAR; 2The First Affilaited Hospital of Medical College, Jinan University; 3GE Medical Systems Asia. 1327.Cortical Effects of Acupuncture Using fMRI: Results of a Randomized Double-Blinded Study Isabel Gareus1, Anja-Carina Schulte1, K. M. Hu1, M. Lacour1, Jürgen Hennig1 1University of Freiburg, Freiburg, Germany. fMRI: Animal Models Hall 4 Wednesday: 13:30 - 15:30 1328.Pharmacological fMRI Method for Animal Brain Based on Mn2+-induced Activity Specific Contrast Fumiyuki Mitsumori1, M. Kumagai2 1National Institute for Environmental Studies, Onogawa, Tsukuba, Japan; 2National Institute for Environmental Studies and University of Tsukuba, Tsukuba, Japan. 1329.Contribution of Resting and Activation-Induced Cerebral Blood Volume Changes to BOLD Signal Changes in the Rat Whisker Barrel Model Kathleen (Donahue) Schmainda1, Andrew S. Greene1, Anthony G. Hudetz1, Thomas J. Ross1, Elliot A. Stein1 1Medical College of Wisconsin, Milwaukee, WI, USA. 1330.Temporal Dynamics of Cerebral Blood Volume and BOLD Responses Noam Harel1, Sang-Pil Lee1, Timothy Duong1, Dae-Shik Kim1, Tsukasa Nagaoka1, Muthiah Thiyagarajan1, Seong-Gi Kim1 1University of Minnesota Medical School, Minneapolis, MN, USA. 1331.fMRI in Mouse at 11.7 Tesla Eric T Ahrens1, David Dubowitz2, David Laidlaw3 1Carnegie Mellon University, Pittsburgh NMR Center for Biomedical Research, Pittsburgh, PA, USA; 2California Institute of Technology, Pasadena, CA, USA; 3Brown University, Providence, RI, USA. 1332.In Vivo fMRI Study of Hypothalamus Activation during Thermoregulation in the Rat G. Vanhoutte1, M. Verhoye1, E. Raman1, A. Van der Linden1 1University of Antwerp, Antwerp, Belgium. 1333.BOLD and NC100150 Contrast Enhanced fMRI of the Cortex and Cerebellum of the Rat during Electrical Stimulation of the Paw. R. R. Peeters1, N. Van Camp1, A. Van der Linden1 1RUCA, Antwerp, Belgium. 1334.Enhanced fMRI using Iron Oxide Contrast Agent in Awake, Behaving Primates Joseph B Mandeville1, Wim Vanduffel2, Denis Fize2, Koen Nelissen2, Bruce R Rosen1, Roger B Tootell1, Paul Van Hecke2, Guy A Orban2 1Massachusetts General Hospital NMR Center, Charlestown, MA, USA; 2Katholieke Universiteit Leuven, Leuven, Belgium. 1335.Imaging Brain Activity in Fully Conscious Monkeys in Response to Sexually Relevant Olfactory Cues Craig F. Ferris1, Charles T. Snowdon2, Jean A. King1, Timothy Q. Duong3, Toni E. Ziegler4, David P. Olson1, Reinhold Ludwig5, Nancy Schultz-Darken4, Zigi Wu5, Pamela Tannenbaum4, John Sullivan5, Seong-Gi Kim3, John Thomas Vaughan Jr3 1University of Massachusetts Medical School (Worcester), Worcester, MA, USA; 2University of Wisconsin-Madison, Madison, WI, USA; 3University of Minnesota, Minneapolis, MN, USA; 4University of Wisconsin-Madison, Wisconsin Regional Primae Research Center, Madison, WI, USA; 5Worcester Polytechnic Institute, Worcester, MA, USA. 1336.fMRI Studies of Eyeblink Conditioning in Conscious Rabbits Nan-kuei Chen1, Limin Li1, Craig Weiss2, John F. Disterhoft2, Alice M. Wyrwicz3 1Northwestern University, ENH Research Institute, Evanston, IL, USA; 2Northwestern University Medical School, Chicago, IL, USA; 3ENH Research Institute and Department of Neurobiology and Physiology, Northwestern University, Evanston, IL, USA. 1337.A New MRI-Method for the Estimation of CMRO2-Changes during Functional Activation in Rats Michael Burke1, Wolfram Schwindt1, Mathias Hoehn1 1Max-Planck-Institut für neurologische Forschung, Köln, Germany. 1338.Mismatch between Activated Areas found by BOLD, CBF and Changes in CMRO2 during Somatosensory Stimulation in the Rat Cortex Michael Burke1, Wolfram Schwindt1, Mathias Hoehn1 1Max-Planck-Institut für neurologische Forschung, Köln, Germany. 1339.Bicuculline-induced Brain Activation in Mice Detected By Functional Magnetic Resonance Imaging Thomas Mueggler1, Diana Baumann, Andre Sauter, Markus Rudin 1Novartis Pharma Ltd, Basel, Switzerland. 1340.Effect of Dopamine D1 Agonist and Antagonist on the Rat Brain as Determined using BOLD fMRI Aisling Lisa Dixon1, Malcolm Prior2, Yasmene Banu Shah2, Peter Gordon Morris2, Andrew Young1, Michael Joseph1 1University of Leicester, Leicester, UK; 2University of Nottingham, Nottingham, UK. 1341.Effects of Repeated Amphetamine Administration on the Dopaminergic System as Detected by phMRI Aisling Lisa Dixon1, Malcolm Prior2, Yasmene Shah2, Peter Gordon Morris2, Andrew Young1, Michael H. Joseph1 1University of Leicester, Leicester, Leicestershire, UK; 2University of Nottingham, Nottingham, Nottinghamshire, UK. 1342.Cocaine Methiodide-Induced Peripheral Vascular Effect on fMRI BOLD Signal in Rat Brain Feng Luo1, Gaohong Wu1, Zhu Li1, Xiaoli Zhao1, Shi-Jiang Li1 1Medical College of Wisconsin, Milwaukee, WI, USA. 1343.Blood Pressure Changes Induced by Arterial Blood Withdrawal Influence BOLD signal in Anesthesized Rats at 7Tesla: Implications For Pharmacologic MRI (phMRI) Raffael Kalisch1, Gregor-K. Elbel1, Christoff Gössl1, Michael Czisch1, Dorothee P. Auer1 1Max Planck Institute of Psychiatry, Munich, Germany. 1344.Functional Imaging of the Early and Late Response to Noxious Formalin Ursula I. Tuor1 1University of Manitoba and National Research Council, Winnipeg, Manitoba, Canada. 1345.Effects of the Cannabinoid Agonist HU210 on BOLD Response in Rat Brain as Determined by fMRI Yasmene Banu Shah1, Malcolm Prior1, Aisling Lisa Dixon2, Charles Alexander Marsden1, Peter Gordon Morris1 1University of Nottingham, Nottingham, UK; 2University of Leicester, Leicester, UK. High-Field Neuro MR Imaging Hall 4 Thursday: 13:30 - 15:30 1346.Fast Mapping of T1 Relaxation Times in the Human Brain Gray and White Matters at 7 Tesla Jae-Hwan Kwag1, Xiaoliang Zhang1, Xiao-Hong Zhu1, Peter Andersen1, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA. 1347.Optimization of Gradient-Recalled Echo MRI of the Brain at 3.0 T Zaki Taher1, Jeff Korzan1, Derek J Emery1, Christian Beaulieu1 1University of Alberta, Edmonton, Alberta, Canada. 1348.Basic Studies of 3D Fast Real IR Takashi Ishimori1, Satoru Nakano1, Yasutane Mori1, Toshiaki Kusuhara1, Motoomi Ohkawa1, Yuichi Yamashita2, Satoshi Sugiura3 1Kagawa Medical Unversity, Kagawa, Japan; 2Toshiba Medical Systems Co., Japan; 3Toshiba Corp. Medical R&D Center, Japan. 1349.Routine Clinical Head MRI at 3.0 T with Optimized RF Power Management James W. Hugg1, Matthew A. Bernstein2, Saul Stokar1, Chen Lin2, Daniel Rosenfeld1, Joel P. Felmlee2, Avram Montag1, John Huston III2, Benjamin Assif1, H. Glenn Reynolds3 1G. E. Medical Systems, Haifa, Israel; 2Mayo Clinic and Foundation, Rochester, MN, USA; 3G. E. Medical Systems, Milwaukee, WI, USA. 1350.Dependence of Magnetization Transfer and Direct Saturation on Flip Angle of Binomial Saturation Pulses: Investigation in White Matter and Deep Gray Matter In Vivo at 3.0 T Neil Gelman1, James R. Ewing2, Jay M. Gorell2, Eric M. Spickler2, Enez G. Solomon2 1Lawson Research Institute, St. Joseph's Health Care Center, London, Ontario, Canada; 2Henry Ford Hospital and Health Sciences Center, Detroit, MI, USA. 1351.MDEFT Turbo Spin Echo (TSE) – Clinical T1 Imaging at 3.0 T Rolf Lamerichs1, Matthias Stuber2, Paul Folkers1, Paul Harvey1, Peter Boesiger3 1Philips Medical Systems, Best, Netherlands; 2Philips Medical Systems, Beth Israel Deaconess Medical Center, Boston, MA, USA; 3University and ETH Zurich, Zurich, Switzerland. 1352.The Measured T2* of Human Brain with Macroscopic Field Inhomogeneity Compensation at 7 Tesla Haiying Liu1, Xiaoliang Zhang1, Qing X Yang2, Michael B Smith2, Kamil Ugurbil1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA; 2Pennsylvania State University, Hershey, PA, USA, Pediatric Neuro MR Imaging Hall 4 Thursday: 13:30 - 15:30 1353.Age at Hypoxia and the Pattern of Neuropathology in Children with Developmental Amnesia Claire H. Salmond1, Faraneh Vargha-Khadem1, Karl J. Friston2, Mortimer Mishkin3, David G. Gadian1 1University College London, Institute of Child Health, London, UK; 2University College London, Institute of Neurology, London, UK; 3National Institute of Mental Health, Bethesda, MD, USA. 1354.Low Field Strength Magnetic Resonance Imaging on the Neonatal Intensive Care Unit. Elspeth Helen Whitby1, Martyn Paley1, Michael F Smith2, Alan Sprigg3, Sharon Rothwell1, Paul David Griffiths1 1University of Sheffield, Royal Hallamshire Hospital, Sheffield, S Yorks, UK; 2Jessop Hosptial for Women, Sheffield, S Yorks, UK; 3Sheffield Children's Hospital, Sheffield, UK. 1355.Quantitative MR Assessment of Changes in White Matter of Children Treated for ALL with High-Dose Methotrexate Wilburn E. Reddick1, John O. Glass1, James W. Langston1, Kathleen J. Helton1 1St. Jude Children's Research Hospital, Memphis, TN, USA. 1356.LC-Model Analysis of Anterior Cingulate 1H MRS in Juvenile Bipolar Disorder Pablo A Davanzo1, Kenneth Yue1, Amir Huda1, T.N Venkatraman1, Albert Thomas1 1University of California, Los Angeles, Los Angeles, CA, USA. Neuro MR Imaging: Miscellaneous Hall 4 Thursday: 13:30 - 15:30 1357.Serial MR Imaging of Magnetodendrimer-Tagged Oligosphere Brain Transplant J.W.M. Bulte1, B. Witwer2, S-C Zhang2, B.K Lewis1, P.van Gelderen1, Trevor Douglas3, I.D Duncan2, J.A Frank1 1National Institutes of Health, Bethesda, MD, USA; 2University of Wisconsin, School of Veterinary Medicine, Madison, WI, USA; 3Temple University, Philadelphia, PA, USA. 1358.A Preliminary Study of the Short T2 Component of White Matter Hyperintensities Babak Ardekani1, Steven J. Choi1, Glyn Johnson2, Kelvin Lim1 1The Nathan S. Kline Institute, Orangeburg, NY, USA; 2New York University, New York, NY, USA. 1359.Detection of Ultra Short T2 Species in Human White Matter by MAS NMR and Multiexponential T2 Analysis Anita Ramani1, AE Aliev2, Gareth Barker3, Paul Stephen Tofts1 1University College London, Institute of Neurology, London, England, UK; 2University College London, London, England, UK; 3The National Hospital, Institute of Neurology, London, England, UK, 1360.Assessment of Vascular Related Brain Lesions Using High-Resolution MR BOLD Venography Jürgen R. Reichenbach1, Clemens Fitzek1, Lars Jonetz-Mentzel2, E. Mark Haacke3, Werner A. Kaiser1 1Friedrich-Schiller-Universität Jena, Jena, Germany; 2Klinikum Erfurt, Erfurt, Germany; 3The Magnetic Resonance Imaging Institute for Biomedical Research, St. Louis, MO, USA. 1361.Lesion Detection using KRISP FLAIR Amy H Herlihy1, Joseph V Hajnal1, Angela Oatridge1, Walter L Curati1, Basant K Puri1, Graeme M Bydder1 1Hammersmith Hospital Campus, Imperial College School of Medicine, London, England, UK. 1362.Brain Magnetic Resonance Imaging Artifacts in Patients with Mechanical Heart Valve Defects Maarten J. van Gorp1, Jan-Henry Seppenwoolde1, Bas A.J.M. de Mol2, Yolanda van der Graaf1, Chris J.G. Bakker1, Theo D. Witkamp1, Lino M.P. Ramos1, Willem P.Th.M. Mali1 1University Medical Center Utrecht, Utrecht, The Netherlands; 2Academic Medical Center, Amsterdam, The Netherlands. 1363.Optimized High Resolution Fixed Cadaver Brain Imaging Valentina Petre1, Michel Petrides2, John G. Sled2, Scott Mackey2, Noor Kabani2, Louis D. Collins2, G. Bruce Pike2 1McGill University, Montreal, PQ, Canada; 2Montreal Neurological Institute, Montreal, PQ, Canada. 1364.Analysis of Tissue Contrast in CE-FLAIR Images by Computer Simulation Map Teruhiko Shimizu1, Hitoshi Miki1, Keiichi Kikuchi1, Junpei Ikezoe1, Kenya Murase1 1Ehime University, Ehime Japan. 1365.Model for Interecho Time Dependence of the CPMG Relaxation Rate in Iron-Rich Brain Tissue Jens H. Jensen1, Ramesh Chandra1 1New York University School of Medicine, New York, NY, USA. 1366.Multiparametric Quantitation of Perilesional Region in Patients with Healed/Healing Solitary Cysticercus Granuloma Rajesh Kumar1, Rakesh K Gupta1, Ram KS Rathore2, Sajja B Rao2, Sanjeev Chawla1, Sunil Pradhan1 1Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India; 2Indian Institute of Technology, Kanpur, UP, India. 1367.Multi-Component T2 Relaxation as a Probe of Demyelination and Inflammation in Rat Sciatic Nerve Following Trauma Stephanie Webb1, Catherine A Munro1, Rajiv Midha1, Greg J Stanisz1 1Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, Canada. 1368.Temperature Dependence of the T2 Spectrum of Peripheral Nerve Keith Wachowicz1, Richard E. Snyder1 1University of Alberta, Edmonton, AB, Canada. 1369.Changes in Brain Size in Hyper- and Hypo-thyroidism Angela Oatridge1, Maria Barnard1, Basant K. Puri1, Joseph V. Hajnal1, Nadeem Saeed1, Graeme M. Bydder1 1Hammersmith Hospital, Imperial College School of Medicine, London, England, UK. 1370.Evaluation of Cerebellar Atrophy and Severity of Alzheimer´s Disease by Automated Magnetic Resonance Brain Segmentation and Volumetry Mieko Matsui1, Setsu Sakamoto1, Kazunari Ishii1, Yutaka Hata2, Etsuro Mori1 1Hyogo Institute for Aging Brain & Cognitive. Dis., Himeji, Japan; 2Himeji Institute of Technology, Himeji, Japan. 1371.Age-Related MT and DT MRI Changes in Normal Subjects Giuseppe Iannucci1, Mara Cercignani1, Maria Pia Sormani1, Massimo Filippi1 1H San Raffaele, Milan, Italy. 1372.Cerebral Flow and Volumetric MTR Parameters in the Elderly. Aart Spilt1, Mark Van Buchem1 1Leiden University Medical Center, Leiden, The Netherlands. 1373.Gender Differences in Brain Morphology: Voxel Based Morphometry in 102 Healthy Young Women and Men Christian Kaufmann1, Marko Wilke1, Benno Pütz1, Dorothee P. Auer1 1Max Planck Institute of Psychiatry, Munich, Germany. 1374.Cerebral Asymmetry: A Voxel Based Morphometry Study of 465 Normal Adult Brains Catriona Diana Good1, Ingrid Johnsrude1, John Ashburner1, Karl J. Friston1, Richard S. Frackowiak1 1University College London, London, UK. 1375.Brain Volume Variability in Healthy Humans: Possible Implication to Clinical Trials H Petropoulos1, W L Sibbitt Jr, E J Bedrick, M A Barlow, B L Hart, F W Rupp, William M Brooks 1University of New Mexico Health Sciences Center, Albuquerque, NM, USA. 1376.Comparison of Methods to Quantify Longitudinal MRI Change in Dementia Valerie A Cardenas1, Antao Du1, Dawn Hardin1, Frank Ezekiel1, Patrice Weber1, William J. Jagust2, Helena C. Chui3, Norbert Schuff1, Michael Weiner1 1University of California, San Francisco, San Francisco, CA, USA; 2University of California, Davis, Sacramento, CA, USA; 3University of Southern California, Downey, CA, USA. 1377.Age and Gender Effects on Brain Grey and White Matter Volumes in Normal Controls: The Reproducibility and Sensitivity of an SPM Based Segmentation Methodology D.T. Chard1, Geoffrey Parker2, Colette Maria Griffin2, A. J. Thompson1, D. H. Miller1 1University College London, London, England, UK; 2Institute of Neurology, London, England, UK. 1378.Automated MRI Voluming of Hippocampus in Alzheimer Disease Yuan-Yu Hsu1, Norbert Schuff2, Antao Du2, Xiaoping Zhu2, Dawn Hardin2, Michael W Weiner2 1Chang Gung Memorial Hospital, Taipei, Taiwan; 2VA Medical Center, University of California, San Francisco, San Francisco, CA, USA. 1379.Heritability of Corpus Callosum Anisotropy in Elderly Twin Men Adolf Pfefferbaum1, Edith V. Sullivan2, Dorit Carmelli1 1SRI International, Menlo Park, CA, USA; 2Stanford University, School of Medicine, Stanford, CA, USA. 1380.Matching MTR Histograms for Multi-Centre Studies Paul Stephen Tofts1, Sca Steens2, Jamshid Dehmeshki1, Paul Hofman3, Jan Hein Van Waesberghe4, Mark Van Buchem2 1University College London, Institute of Neurology, London, UK; 2Leiden University Medical Center, Leiden, The Netherlands; 3University Hospital Maastricht, Maastricht, The Netherlands; 4Academic Hospital VH, Amsterdam, The Netherlands. 1381.Decrease in Cerebral Ventricular Volume in End-Stage Huntington's Disease Treated with Purified Eicosapentaenoic Acid Basant K. Puri1, Serena J. Counsell1, Joseph V. Hajnal1, David F. Horrobin2, Bryan J. Corridan3, Alexandra J. Richardson4, Alan G. Collins1, Heather M. McKee3, Graeme M. Bydder1 1Hammersmith Hospital, London, England, UK; 2Laxdale Research, Stirling, Scotland, UK; 3Ealing, Hammersmith and Fulham Mental Health NHS Trust, England, UK; 4University Laboratory of Physiology, Oxford, England, UK. 1382.Schizophrenia Syndromes Predict Changes in Ventricle-To-Brain Ratios: A Serial High Resolution 3D Magnetic Resonance Imaging Study Using Image Registration and Quantitation Basant K. Puri1, Nadeem Saeed2, Alexandra J. Richardson3, Angela Oatridge1, Joseph V. Hajnal1, Graeme M. Bydder1 1Hammersmith Hospital, London, England, UK; 2Smithkline Beecham, Welwyn, Herts, England, UK; 3University Laboratory of Physiology, Oxford, England, UK. 1383.fMRI of ESP D. Reamer1, Fick T. Shush1, Fool & Hardy1 1Institute of Dreams and Imaginings of Trendy Science (IDIoTS), Buggtussle, USA. Technical Problems and Solutions in Neuro MRI Hall 4 Thursday: 13:30 - 15:30 1384.Cerebrospinal Fluid Pulsation Artifacts in Fluid-Attenuated Inversion Recovery Images: Sequential Versus Interleaved Acquisition Yung-Chih Hsu1, Teng-Yi Huang1, Chao-Ying Wang1, Cheng-Yu Chen2, Hsiao-Wen Chung1 1National Taiwan University, Taipei, Taiwan, ROC; 2Tri-Service General Hospital, Taipei, Taiwan, ROC. 1385.Influence of Head Posture on Diffusion Tensor Imaging (DTI) Miyuki Takasu1, Hiroshi Fukuda1, Tadashi Nakanishi1, Katsuhide Ito1, Toshio Kajima2, Hiroyuki Kabasawa3 1Hiroshima University School of Medicine, Hiroshima, Japan; 2Hiroshima Prefectural College of Health Science, Hiroshima, Japan; 3GEYMS, Tokyo, Japan. 1386.RF Inhomogeneity Compensation and Artifact Reduction in Structural Brain Imaging Ralf Deichmann1, C. D. Good1, J. Ashburner1, Robert Turner1 1Institute of Neurology, University College London, London, UK. Intracranial MR Angiography Hall 4 Monday: 14:00 - 16:00 1387.Contrast-Enhanced MR Angiography for the Detection of Intracranial Aneurysms Kai Yiu Ho1, Dennis L Laurens2, Jan T Wilmink2 1University Hospital Groningen, Groningen Netherlands; 2University Hospital Maastricht, Maastricht, Limburg The Netherlands. 1388.Evaluation of Brain-Tumor Interface on Post-Embolized Intracranial Meningiomas Using Time-Resolved MRA; Comparison with DSA Tae-Sub Chung1, Ralph Strecker2, Jürgen Hennig2 1Yonsei University College of Medicine, YongDong Severance Hospital, KangNam-Ku, South Korea; 2Universität Freiburg, Freiburg, Germany. 1389.Contrast-Enhanced MR Phlebography of the Cerebral Veins Karl O Lovblad1, Jacques Schneider2, Claudio Bassetti1, Luca Remonda1, Gerhard Schroth1 1Inselspital, Bern Switzerland; 2Universitätsspital-Kinderklinik, Zürich, Switzerland. 1390.Post-Contrast 3D TOF MRA: Possible Role in Acute Stroke? Janice J Yang1, Michael D Hill1, William F Morrish1, Mark E Hudon1, Philip A Barber1, Andrew M Demchuk1, Robert J Sevick1, Richard Frayne1 1University of Calgary, Seaman Family MR Centre, Foothills Medical Centre, Calgary, Alberta, Canada. 1391.Measurements of T1 Relaxation times at 3.0T: Implications for Clinical MRA Chen Lin1, Matt Bernstein1, John Huston1, Sean Fain1 1Mayo Clinic, Rochester, MN, USA. 1392.SENSE 3D Time of Flight Angiography Using a 4-Channel Head Coil Kevin King1, H. Glenn Reynolds2, Matt Bernstein2, L. Estkowski1, L. Angelos1, Donna Feo3, William Monski3, Maren Wagner4 1G. E. Medical Systems, Milwaukee, WI, USA; 2Mayo Clinic, Rochester, MN, USA; 3Medrad, Inc., Indianola, PA, USA; 4Erlangen, Germany. 1393.Real Time Alternate Multiplanar MR-DSA: Evaluation of Endovascular Embolization of Intracranial Arterio-Venous Malformations Thierry Metens1, Fatima Rio1, Danielle Baleriaux1, Thierry Roger1, Carine Neugroschl1, Georges Rodesch1 1ULB-Erasme, Brussels, Belgium. 1394.Assessment of Vascular Malformations in the Head and Neck with Two-Dimensional MR Digital Subtraction Angiography (2D MRDSA) Toshiyuki Okubo1, Takeharu Yoshikawa2, Masaaki Hori1, Keiichi Ishigame1, Shigeki Aoki3, Osamu Abe3, Tsutomu Araki1, Kuni Ohtomo3 1Yamanashi Medical University, Yamanashi Japan; 2Tokyo University, Tokyo Japan; 3University of Tokyo, Faculty of Medicine, Tokyo, Japan. 1395.Flow Direction of the Posterior Communicating Artery as a Risk Factor for Ischemic Borderzone Infarction. Jeroen Hendrikse1, Jeroen Van der Grond1 1UMC, Utrecht, the Netherlands. 1396.Phase Encoding Flow Compensation in High Resolution Intracranial MRA Dennis Lee Parker1, Andrew Alexander1, John A. Roberts1, K. Craig Goodrich1, Gregory Katzman1, Jay Tsuruda1 1University of Utah, Salt Lake City, UT, USA. Intracranial Tumors Hall 4 Monday: 14:00 - 16:00 1397.Comparision of MRI and SPECT Tumour Volume Measurement Following Minimally Invasive Surgery For a Phase 1 Trial of a Genetically Modified Viral Therapy David Brennan1, Donald Hadley1, Jim Patterson1, Barrie Condon1 1Southern General Hospital, Glasgow, Scotland, UK. 1398.Peritumoral Brain Edema in Meningiomas: Relevance of White Matter Lesions in Centrum Semiovale Norio Hirabuki1, Hisashi Tanaka1, Hideaki Yoshimura1, Norihiko Fujita1, Hironobu Nakamura1 1Osaka University Medical School, Suita, Osaka Prefecture, Japan. 1399.Comparison of Two Brain Tumor-Localizing MRI Agents, GD-BOPTA and GD-DTPA. MRI and ICP Study of Rat Brain Tumor Model Tian Zhang1 1University of Tsukuba, Tsukuba, Ibaraki Japan. 1400.Improved Visualization of Meningeal Enhancement by Contrast-Enhanced T1-Weighted Black-Blood Fast Spin-Echo Imaging with Short Repetition, Echo, and Inversion Times Yasuo Amano1, Ryo Takagi1, Tatsuo Kumazaki1, Katsuya Takahama1, Maki Amano1 1Nippon Medical School, Tokyo, Japan. 1401.Intra-Patient Comparison Of Gadobenate Dimeglumine To Routinely Used Contrast Agents For The Detection Of Intracranial Metastases Roberto La Ferla1, Cesare Colosimo2, Jordi Ruscalleda3, M. Korves4, Corinne Wool1, Paola Pianezzola1 1Bracco SpA, Milan, Italy; 2University G. D'Annunzio, Chieti, Italy; 3Hospital de la Santa Cruz y San Pablo, Barcelona, Spain; 4Charité University, Berlin, Germany. MR Imaging of Epilepsy Hall 4 Tuesday: 13:30 - 15:30 1402.Usefulness of Apparent Diffusion Coefficient Value for Lateralization of Epileptogenic Lesion in Patients with Hippocampal Sclerosis So Young Yoo1, Kee-Hyun Chang1, In Chan Song1, Moon Hee Han1, Sang Hyun Lee1, In Gyu Yu1, Chun-Kee Chung2 1Seoul National University Hospital, Seoul, Korea; 2Seoul National University College of Medicine, Seoul, Korea. 1403.Magnetisation Transfer Imaging in Patients with Cerebral Dysgenesis, Cryptogenic and Acquired Partial Epilepsies Fergus Rugg-Gunn1, Philip Boulby1, Sofia Eriksson1, Mark Symms1, Gareth Barker1, John Duncan1 1Institute of Neurology, London, UK. 1404.Hippocampal T2-relaxometry and Hippocampal Volumes: Do They Measure the Same Pathology? Regula S. Briellmann1, Renate M. Kalnins2, Samuel F. Berkovic3, Graeme D. Jackson1 1Brain Research Institute, Heidelberg, Victoria, Australia; 2University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia; 3Epilepsy Research Institute, Heidelberg, Victoria, Australia. 1405.Diffusion Tensor Imaging in the Hippocampus using ZOOMed EPI Philip Andrew Boulby1, Mark Symms2, Claudia Wheeler-Kingshott3, Geoffrey Parker1, Gareth Barker4 1Institute of Neurology, London, England, UK; 2National Society for Epilepsy, Gerrards Cross, England, UK; 3Surrey, England, UK; 4The National Hospital, Institute of Neurology, London, England, UK. 1406.A Longitudinal Quantitative MRI Study of Community-Based Patients with Chronic Epilepsy and Newly Diagnosed Seizures: Methodology and Preliminary Findings Rebecca S N Liu1, Louis Lemieux1, Gail S Bell1, Philippa Bartlett2, Josemir W A S Sander1, Sanjay M Sisodiya1, Simon D Shorvon3, John S Duncan1 1University College London, Institute of Neurology, Chalfont St Peter, Buckinghamshire, England, UK; 2National Society for Epilepsy, Bucks, England, UK; 3University College London, Institute of Neurology, London, England, UK. MR Imaging of Multiple Sclerosis Hall 4 Tuesday: 13:30 - 15:30 1407.Correlates of MS Disability Assessed In Vivo using Aggregates of MR Quantities Marco Rovaris1, Caterina Mainero1, Nicola De Stefano2, Giuseppe Iannucci1, Lionello Guidi3, Antonio Federico2, Giancarlo Comi1, Massimo Filippi1 1H San Raffaele, Milan, Italy; 2Institute of Neurological Sciences, University of Siena, Siena, Italy; 3Ospedale di Empoli, Empoli, Italy. 1408.Intra-Observer, Inter-Observer and Inter-Scanner Variations in Brain MRI Volume Measurements in Multiple Sclerosis Marco Rovaris1, Claudio Gasperini2, Maria Pia Sormani1, Stefano Bastianello3, Carlo Pozzilli3, Giancarlo Comi1, Massimo Filippi1 1H San Raffaele, Milan, Italy; 2Ospedale San Camillo-Forlanini, Rome, Italy; 4University La Sapienza, Rome, Italy. 1409.A Diffusion Tensor MR Imaging Study of Cognitive Dysfunction in Patients with Mildly-Disabling Multiple Sclerosis Marco Rovaris1, Giuseppe Iannucci1, Monica Falautano1, Francesca Possa1, Vittorio Martinelli1, Giancarlo Comi1, Massimo Filippi1 1H San Raffaele, Milan, Italy. 1410.Brain Damage in Primary-Progressive MS Assessed by Diffusion Tensor MRI Marco Bozzali1, Giuseppe Santuccio1, Marco Rovaris1, Mara Cercignani1, Giancarlo Comi1, Massimo Filippi1 1Scient. Inst. HSR, Milan, Italy. 1411.Correlations between Measures of Multiple Sclerosis Pathology Derived from T2, T1, Magnetization Transfer and Diffusion Tensor MR Imaging Giuseppe Iannucci1, Marco Rovaris1, Laura Giacomotti1, Giancarlo Comi1, Massimo Filippi1 1H. San Raffaele, Milan, Italy. 1412.Serial and Regional Water Content and Myelin Water Content in New Large Multiple Sclerosis Lesions Irene Vavasour1, Kenneth Whittall1, Alex MacKay1, D. K.B. Li1, D. W. Paty1 1University of British Columbia, Vancouver, BC, Canada. 1413.MS Normal Appearing White Matter has Heterogeneous, Diffusely Prolonged T2 Kenneth Whittall1, Alex MacKay1, DKB Li1, Irene Vavasour1, C. K. Jones1, D. W. Paty1 1University of British Columbia, Vancouver, BC, Canada. 1414.Atrophy Measurements in Multiple Sclerosis Craig Jones1, David KB Li1, GuoJun Zhao1, Donald W. Paty1, PRISMS Study Group 1University of British Columbia, Vancouver, BC, Canada. 1415.Diffusion Tensor Imaging in Multiple Sclerosis Matilde Inglese1, Mara Cercignani1, Giancarlo Comi1, Massimo Filippi1 1H San Raffaele, Milan, Italy. 1416.Gray and White Matter Involvement in Alzheimer Disease: A Diffusion Tensor and Magnetization Transfer Imaging Study In Vivo Marco Bozzali1, Silvia Pontesilli1, Massimo Franceschi2, Andrea Falini1, Mara Cercignani1, Giuseppe Scotti1, Giancarlo Comi1, Massimo Filippi1 1Scientific Institute H San Raffaele, Milan, Italy; 2H Castellanza, Milan, Italy. 1417.Accurate Measurement of the Dominant T2 Time Constants in Multiple Sclerosis Lesions Keith S Cover1, David Li1, Donald W Paty1 1University of British Columbia, Vancouver, BC, Canada. 1418.Mean Diffusivity and Fractional Anisotropy Histograms in Patients with Multiple Sclerosis Mara Cercignani1, Matilde Inglese1, Elisabetta Pagani1, Giancarlo Comi1, Massimo Filippi1 1Scientific Inst. H. San Raffaele, Milan, Italy. 1419.Quantitation of Diffusion Weighted MRI and its Relationship to Clinical and Cognitive Disability in Multiple Sclerosis Katherine Lymer1, David Moriarty1, Valerie F. Hillier2, Alan Jackson1 1University of Manchester, Manchester, England, UK; 2University of Manchester, London, England, UK. 1420.White Matter Fibre Tractography in Multiple Sclerosis Using Diffusion Tensor Imaging. C R Tench1, M Wilson1, P S Morgan1, L D Blumhardt1 1University of Nottingham, Nottingham, England, UK. 1421.MTR Histogram Descriptives of White Matter Depend on the Chosen Segmentation: A Multiple Sclerosis Study Nils Bodammer1, Gareth J. Barker2, Thomas Eckert1, Claus Tempelmann1, Hans-Jochen Heinze1, Michael Sailer1 1O.v.G. University, Magdeburg, Germany; 2Institute of Neurology, Queen Square, London, UK. 1422.Enhanced Detection of Demyelination of Multiple Sclerosis Using Independent Component Analysis Toshiharu Nakai1, Shigeru Muraki2, Kayako Matsuo1, Yukio Miki3 1AIST / Kobe AMC, Ikeda, Osaka Japan; 2Electrotechnical Lab, Tsukuba, Japan; 3Kyoto University Hospital, Sakyo-ku, Kyoto, Japan. 1423.Global Analysis of Tissue Integrity and Water Shifts in the Normal Appearing White Matter of MS Patients Stefan Ropele1, Franz Ebner1, Hans-Peter Hartung1, Franz Fazekas1 1University of Graz, Graz, Austria. 1424.In Vivo T2 Brain Histogram in Multiple Sclerosis Denis Grenier1, Daniel Pelletier2, David C. Newitt1, Sarah J. Nelson1, Donald E Goodkin2, Sharmila Majumdar1 1University of California, San Francisco, San Francisco, CA, USA; 2Mount Zion Multiple Sclerosis Center, University of California San Francisco, San Francisco, CA, USA. 1425.Analysis of SPGR Intensity Histograms for the Characterization of Brain Matter Changes in Multiple Sclerosis David C. Newitt1, Daniel Pelletier1, Kim Dao1, Sarah J. Nelson1 1University of California, San Francisco, San Francisco, CA, USA. 1426.MT- and DT-MR of the Optic Radiations and Calcarine Cortex from Patients with Leber's Hereditary Optic Neuropathy Matilde Inglese1, Marco Rovaris1, Stefania Bianchi1, Giancarlo Comi1, Massimo Filippi1 1H San Raffaele, Milan, Italy. MR Imaging of Stroke and Vascular Disorders Hall 4 Tuesday: 13:30 - 15:30 1427.Mismatch Development in Acute Atroke Patients Treated with Intravenous Thrombolytic Therapy Bert Schleper1, Jens Fiehler1, Thomas Kucinski1, Cornelius Weiller1, Hermann Zeumer1, Joachim Roether1 1University of Hamburg, Hamburg, Germany. 1428.The Fate of Saved "Tissue at Risk of Infarction" Joachim Roether1, Bert Schleper1, Jens Fiehler1, Thomas Kucinski1, Rene Knab1, Karl H. Bohuslavizki1, Hermann Zeumer1, Cornelius Weiller1 1University Hospital Hamburg Eppendorf, Hamburg, Germany. 1429.Combined Diffusion and Perfusion MRI in Acute Ischemic Stroke: Prediction of Outcome at Three Months Jari O. Karonen1, Ritva L. Vanninen1, Reina Roivainen1, Pauli Vainio1, Yawu Liu1, Kaarina Partanen1, Juhani Sivenius1, Esko Vanninen1, Jyrki T. Kuikka1, Leif Østergaard2, Hannu J. Aronen1 1Kuopio University Hospital, Kuopio University, Kuopio, Finland; 2Århus University Hospital, Århus, Denmark. 1430.Perfusion and Diffusion Weighted MR Imaging during First 5 Hours after Stroke Symptoms Onset Compared to 3 Months Patient Outcome Olav Haraldseth1, Per Arvid Steen1, Bjørn Cederin2, Gunnar Myhr1, Kjell Arne Kvistad1, Bent Indredavik2 1Norwegian University of Science and Technology, Trondheim, Norway; 2University Hospital, Trondheim, Norway. 1431.Multiparametric MRI ISODATA of Human Stroke Segments the Ischemic Lesion According to Degree of Ischemic Injury Mamatha Pasnoor1, Panayiotis D Mitsias1, Suresh C Patel1, Hamid Soltanian-Zadeh1, Sunitha Santhakumar1, Rabih Hammoud1, Nikolaos IH Papamitsakis1, Mei Lu1, Michael A Jacobs2, Donald Peck1, Michael Chopp1 1Henry Ford Health System, Detroit, MI, USA; 2Johns Hopkins University, Reistertown, MD, USA. 1432.MRI in Acute Basilar Artery Thrombosis: A Case Series Tobias Neumann-Haefelin1, Richard du Mesnil1, Matthias Sitzer1, Heinrich Lanfermann1 1Goethe-University, Frankfurt, Germany. 1433.Microscopic Flow Heterogeneity: Its Determination by PWI and Role in Cerebral Oxygen Metabolism Leif Østergaard1, David A Chesler2, Albert Gjedde1, Ona Wu2, Carsten Gyldensted1, Bruce R Rosen2, Greg Sorensen2 1Århus University Hospital, Århus, Denmark; 2Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. 1434.Flow Heterogeneity Measurement May Improve Estimation of Final Infarct Size in Acute Stroke. Claus Z. Simonsen1, Lisbeth Røhl1, Peter Vestergaard-Poulsen1, Carsten Gyldensted1, Leif Østergaard1 1Århus University Hospital, Århus, Denmark. 1435.Prediction of Tissue Outcome in Acute Cerebral Ischemic Stroke Using Perfusion MR Imaging and SPECT Jae-Hyoung Kim1, Eun-Ja Lee1, Sun-Joo Lee1, Kyeong-Hun Kang1, Taemin Shin1 1Gyeongsang University Hospital, Jinju, Korea. 1436.Dynamic Susceptibility Contrast MRI for Acute Cerebral Ischemia and Cerebral Gliomas: Relationship of Maximum Signal Drop with Cerebral Blood Flow and Cerebral Blood Volume Yi-Jui Liu1, Ing-Jye Huang1, Fu-Nien Wang1, Cheng-Yu Chen2, Hsiao-Wen Chung1 1National Taiwan University, Taipei, Taiwan, ROC; 2Tri-Service General Hospital, Taipei, Taiwan, ROC. 1437.Clinical Evaluation of Non-Invasive Perfusion-Weighted MRI for Cerebral Ischemic Lesions Miyuki Takasu1, Katsuhide Ito1, Tomohide Akimitsu1, Kaoru Kurisu1, Toshio Kajima2, Hiroyuki Kabasawa3 1Hiroshima University School of Medicine, Hisoshima, Japan; 2Hiroshima Prefectural College of Health Science, Hiroshim, Japan; 3GEYMS, Tokyo, Japan; 1438.MR Perfusion Imaging Predicts Anterior Cerebral Artery Territory Infarct Following Acute Aneurismal Sub-Arachnoid Haemorrhage Adam D. Waldman1, N. Kitchen1, H. R. Jager1, T. C. Cox1 1National Hospital for Neurology & Neurosurgery, London, England, UK. 1439.Simple Method for Estimation of Cerebral Perfusion Reserve by BOLD Images Akihiko Shiino1 1Shiga University of Medical Science, Ohtsu, Shiga Japan. 1440.Short-Term Cerebral Haemodynamic Consequences of Carotid Endarterectomy Iain D Wilkinson1, Jonathan D Beard2, Nigel Hoggard1, Paul D Griffiths1, Graham S Venables2 1University of Sheffield, Royal Hallamshire Hospital, Sheffield, England, UK; 2Sheffield Teaching Hospitals NHS Trust, Sheffield, England, UK. 1441.Reliability of Cerebral Blood Volume and Mean Transit Time Measured with Perfusion MR Imaging in Assessing the Hemodynamic Disturbance of Symptomatic Carotid Occlusive Disease Jae-Hyoung Kim1, Eun-Ja Lee1, Sun-Ju Lee1, Kyeong-Hun Kang1, Taemin Shin1 1Gyeongsang University Hospital, Jinju, Korea, 1442.Evaluation of Corticospinal Tract Injury to Predict Functional Motor Outcome in Cerebral Vascular Disease Using Diffusion-weighted Echo Planar Imaging Katsusuke Kusunoki1, Yoshihisa Oka1, Ichiro Nochide1, Keiji Igase1, Hironobu Harada1, Kazuhiko Sadamoto1, Kiyoshi Nagasawa2 1Washokai Sadamoto Hospital, Matsuyama, Ehime Japan; 2GE-Yokogawa Medical System, Tokyo, Japan. 1443.Relationship Between Stroke Severity and the ADC of Water: Implications for the Use of DWI in Research and Clinical Practice J.M Wardlaw1, S. L. Keir2, Mark Bastin2, Paul Armitage1, A. K. Rana2 1Western General Hospital, Edinburgh, Scotland, UK; 2University of Edinburgh, Edinburgh, Scotland, UK. 1444.An Investigation into the Clincal Usefulness of Diffusion-Weighted Imaging in Stroke Sarah L. Keir1, Joanna M. Wardlaw1, Mark E. Bastin1, Paul A. Armitage1, Arnab K Rana1 1University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK. 1445.Magnitude and Time-Course of "Exponential" Diffusion Weighted Image Signal Ratio in Stroke James D Eastwood1, James M Provenzale1, David M Delong1, Stefan Engelter2 1Duke University, Durham, NC USA; 2University Hospital Basel, Basel, Switzerland. 1446.The Application of DWI and ADC Map in Cerebral Infarction L Huang1, XH Wong1, SR Liu1, G Li2 1The First Affilaited Hospital of Medical College, Jinan University, Guang Zhou, P. R. China; 2The University of Hong Kong, Hong Kong, HKSAR (GE Medical System of China). 1447.Acute Ischemia Causing Distal Arm Paresis - A Diffusion-Weighted MRI Study Achim Gass1, Kristina Szabo1, Stefan Behrens1, Jochen Hirsch1, Jochen Gaa1, Michael Hennerici1 1Universitaetsklinikum Mannheim der Universitaet Heidelberg, Mannheim, Germany. 1448.The Potential of Arterial Hyerintensity on Fast Fluid-attenuated Inversion-recovery Imaging in Hyperacute Stroke: A Comparison with Diffusion-weighted Imaging Masayuki Maeda1, Hajime Sakuma2, K. Takeda2 1Fukui Medical University, Fukui, Japan; 2Mie University School of Medicine, Tsu, Mie, Japan. 1449.Diffusion-Weighted Imaging of Cerebral Hyperperfusion Injury and Venous Congestion in Comparison with FLAIR and Cerebral Blood Flow Imaging Hiroaki Shimizu1 1Kohnan Hospital, Seindai, Miyagi, Japan. 1450.Diffusion-Weighted Imaging of Dural Sinus Thrombosis Takeharu Yoshikawa1, Osamu Abe, Toshiyuki Okubo, Kazuhiro Tsuchiya, Kimiko Tobe, Tomohiko Masumoto, Naoto Hayashi, Harushi Mori, Haruyasu Yamada, Shigeki Aoki, Kuni Ohtomo 1Tokyo University, Tokyo Japan. 1451.Diffusion-Weighted MR Imaging in MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episode) Syndrome Myung Kwan Lim1, Ji Hye Kim2, Chang Hae Suh3, Hee Young Hwang4 1Incheon, South Korea; 2Gachon Medical Center, Gachon Medical College, Incheon, South Korea; 3Inha University Hospital, Incheon, South Korea; 4Ghil Medical Center, Gachon Medical School, Incheon, South Korea; 1452.Automated Assessment of Brain Atrophy and Abnormal Tissue Quantitation in CADASIL Patients Mario Quarantelli1, Bruno Alfano1, Sabina Pappatà2, Chabriat Hugues2, Michele Larobina1, Enrico Tedeschi1, Arturo Brunetti1, Marco Salvatore3 1Center for Nuclear Medicine, Naples, Italy; 2SHFJ, CEA, Orsay France; 3University of Naples, Naples, Italy. 1453.Relationship of Leukoaraiotic Lesions and Cerebral Blood Flow In Non-Stroke Vascular Patients David Moriarty1, Alan Jackson1, Graham Riding2 1University of Manchester, Manchester, UK; 2Withington Hospital, South Manchester Health Care Trust, Withington, Manchester, UK. 1454.Biomechanical Model of Brain Vasculature Alberto Vazquez1, Luis Hernandez1, Douglas Noll1 1University of Michigan, Ann Arbor, MI, USA. Animal Models of Infarct and Hypoxia Hall 4 Tuesday: 13:30 - 15:30 1455.T1( following Acute Global Cerebral Ischemia in Rats Dependence on Blood Glucose and Interrelation with Diffusion Mikko I. Kettunen1, Olli H.J. Gröhn1, Risto A. Kauppinen1 1A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland. 1456.Time Evolution of Cytotoxic and Vasogenic Edema Measured by DWI and T2 in a Porcine Stroke Model Lisbeth Røhl1, Carsten Gyldensted1, Masaharu Sakoh2, Claus Z Simonsen1, Peter Vestergaard-Poulsen1, Jens C Sørensen1, Leif Østergaard1 1Aarhus University Hospital, Århus, Denmark; 2Ehime University Hospital, Ehime, Japan. 1457.Diffusion and T2 Time Course Changes in a Model of Microsphere Induced Embolic Stroke Orna Mayzel-Oreg1, Tsuyoshi Omae2, Mark Kazemi3, Fuahi Li2, Marc Fisher2, Yoram Cohen1, Christopher H. Sotak3 1Tel-Aviv University, Tel-Aviv, Israel; 2Umass Memorial Health Care and University of Massachusetts Medical School, Worcester, MA, USA; 3Worcester Polytechnic Institute, Worcester, MA, USA. 1458.A Serial MR Study of Cerebral Blood Flow Changes and Lesion Development Following Endothelin-1 Induced Ischemia in Rats Richard Buist1, Jeff Biernaskie2, Hao Lei1, Dale Corbett2, James Peeling1 1University of Manitoba, Winnipeg, MB, Canada; 2Memorial University of Newfoundland, St. John's, NF, Canada. 1459.Evaluation of MRI Tissue Signature Changes Between Embolic and Thrombotic Ischemia Quan Jiang1, Rui Lan Zhang1, Zheng Gang Zhang1, Robert A. Knight1, James R. Ewing1, Jiani Hu2, Qing Jiang Li1, Polly Arniego1, Guang Lian Ding1, Michael Chopp1 1Henry Ford Hospital, Detroit, MI, USA; 2Wayne State University, John R. Harper Hospital, Detroit, MI, USA. 1460.Histopathological Evaluation on Infarct Core, Peri-infarct Border and Intrahemispheric Remote Area in T2 Weighted and Diffusion Weighted MRI Images in the Rat Brain. Masato Nakane1, Hiroshi Toyama1, Hirofumi Anno1, Masayuki Yamada1, Tatsuhiko Okada1, Kaname Matsumura1, Kazuhiro Katada1, Sukehiko Koga1 1Fujita Health University, Toyoake, Aichi Japan. 1461.Comparison of ADC, CBF and T1 in Arterial Occlusive and Photo-Thrombotic Stroke Models, with Microtubule-Associated Protein-2 (MAP2) Immunoreactivity to Determine the Extent of Ischemia Donald S. Williams1, Alexander Kharlmov2, Elena Simplaceanu1, Stephen C. Jones2 1Carnegie Mellon University, Pittsburgh NMR Center, Pittsburgh, PA, USA; 2Allegheny General Hospital, Pittsburgh, PA, USA. 1462.Dynamics of Tissue Status Following 1.5-hour Transient Focal Cerebral Ischemia in the Rat, as Measured using T2- and DW-MRI and 1H-MRS W.B. Veldhuis1, F. Delmas2, P.R. Bär1, K Nicolay1 1University Medical Center, Utrecht, The Netherlands; 2ICSN-CNRS, Gif-sur-Yette, France. 1463.Regional Response of Cerebral Blood Volume to Graded Hypoxia in Rat Brain Jean-Francois Payen1, Cecile Julien-Dolbec2, Irene Tropres2, Olivier Montigon2, Henri Reutenauer2, Anne Ziegler2, Michel Decorps2 1Johns Hopkins University, Baltimore, MD, USA; 2Hôpital Michallon, Grenoble, France, 1464.Monitoring Cerebrovascular Reserve Capacity Following Bilateral Carotid Artery Occlusion In Rat Using Arterial Spin Tagging Perfusion Imaging Richard Buist1, Chunliang Wei1, Vyacheslav Volotovsky2, James Peeling1 1University of Manitoba, Winnipeg, MB, Canada; 2National Research Council of Canada, Winnipeg, MB, Canada. 1465.Altered BBB Permeability in Acute Stroke Studied by Gd-DTPA Enhanced T1-weighted Imaging and 14C- Robert A. Knight1, James R. Ewing1, Taverekere N. Nagaraja1, Vijaya Nagesh1, Polly Arniego1, Susan C. Fagan2, Quan Jiang1, Joseph D. Fenstermacher1 1Henry Ford Hospital, Detroit, MI, USA; 2University of Georgia, Augusta, GA, USA. 1466.Magnetic Resonance Imaging Studies on the Effect of the Antithrombotic Agent Acutobin on Hyperglycemic Rat Middle Cerebral Ischemia/Reperfusion Model Jingna Wei1, Qingchuang Wang2, Kuangfen Liu2, Michael J Quast1 1University of Texas Medical Branch, Galveston, TX, USA; 2Fujian Medical University, Fuzhou, Fujian P.R.of China. 1467.Does Hypothermia Protect Against "Delayed Tissue Damage" Following a Brief Period of Forebrain Ischemia in the Gerbil? Mark Lythgoe1, D. L. Thomas2, M. D. King1, Roger Ordidge2, David Gadian1 1Institute of Child Health, London, England, UK; 2University College London, London, England, UK. 1468.Magnesium Treatment Reduces Ischemic Depolarizations and Lesion Volume after Subarachnoid Hemorrhage in the Rat Walter van den Bergh1 1University Medical Center Utrecht, Utrecht, The Netherlands. 1469.Diffusion MRI of Adult Rat Brain in a Model of Transient Global Ischemia Rodriguez I.1, D. Alonso1, Jesus Ruiz-Cabello1, J. Serrano1, A. P. Fernandez1, Uttenthal L. O.1, J. Rodrigo1 1Complutense University, Madrid, Spain. Animal Brain MR Imaging Hall 4 Tuesday: 13:30 - 15:30 1470.In Vivo Volume Measurement of Song Control Nuclei in the Brain of European Starlings (Sturnus vulgaris) using Manganese-Enhanced MRI V. Van Meir1, M. Verhoye1, I. Tindemans1, P. Absil2, J. Balthazart2, A. Van der Linden1 1University of Antwerp, Antwerp, Belgium; 2University of Liège, Liège, Belgium. 1471.Microscopic Parametric Mapping of the Normal Mouse Brain Todd Ryan Mitchell1, Stanley Thomas Fricke1, Stefan Posse1, Gregory J. Moore1 1Wayne State University, Detroit, MI, USA. 1472.In vivo Tracking of the Neurodegeneration Induced by Intrahippocampal Injections of (-Amyloid Yusuf A. Bhagat1, Andre Obenaus1, J. Steven Richardson1, Edward J. Kendall1 1University of Saskatchewan, Saskatoon, SK, Canada. 1473.Water and Teramethylammonium Diffusion in the Rat Brain with Kaolin-Induced Hydrocephalus Eva Sykova1, Ivan Vorisek2, Jindrich Fiala1 1Charles University, Prague, Czech Republic; 2Institute of Experimental Medicine ASCR, Prague, Czech Republic. 1474.MRI Tracer Study of Bulk Flow of Interstitial and Cerebrospinal Fluid in a New Hydrocephalus Model M Shibata1, C-H Nguy2, S Yamada1, M Scadeng1, S Bluml2, JG McComb1, BD Ross3 1Children's Hospital of Los Angeles, Los Angeles, CA, USA; 2Rudi Schulte Research Institute, Santa Barbara, CA, USA; 3Huntington Medical Research Institutes, Pasadena, CA, USA. 1475.Water Diffusion in Myelin Deficient Rat Spinal Cords Vikas Gulani1, Andrew Webb1, Ian D. Duncan2, Paul Lauterbur1 1University of Illinois at Urbana-Champaign, Urbana, IL, USA; 2University of Wisconsin-Madison, Madison, WI, USA. 1476.Magnetic Resonance Imaging Investigation of a Delayed Type Hypersensitivity Lesion in the Rat Brain. Kerry A Broom1, Daniel Anthony2, Andrew M Blamire1, Hugh Perry2, Peter Styles1, Nicola R Sibson1 1University of Oxford, Oxford, England, UK; 2Southampton University, Southampton, England, UK. 1477.Measurements of Anatomic and Vascular Characteristics in the Brain of Aging Canine with or without Environmental Enrichment and Antioxidant Diet M. Y. Su1, E. Head2, J. Wang1, J. Y. Chiou1, H. Yu1, B. A. Muggenburg2, C. W. Cotman1, O. Nalcioglu1 1University of California, Irvine, CA, USA; 2Lovelace Respiratory Research Institute, Albuquerque, NM, USA. 1478.MRI Detection of Early Reductions in Cerebal Perfusion Following Focal Striatal Injection of the Cytokine TNF-(: Implications for CNS Disease Nicola Sibson1, Andrew Blamire1, V. H. Perry2, Peter Styles1, D. C. Anthony2 1University of Oxford, Oxford, England, UK; 2University of Southampton, Highfield, Southampton, UK. 1479.Quantitative DWI Analysis of Neuroprotection Against Soman-Induced Neuropathology Yusuf A Bhagat1, Andre Obenaus1, Murray G Hamilton2, Edward J Kendall1 1University of Saskatchewan, Saskatoon, Canada; 2Defence Research Establishment Suffield, Medicine Hat, Alberta, Canada. 1480.Kainate Injury in the Rat Brain Evaluated by In Vivo Contrast-Enhanced MRI Robert Frangez1, Marko Zivin2, Franci Demsar3, Katarina Beravs3 1Veterinary Faculty, Ljubljana, Slovenia; 2Medical Faculty, Ljubljana, Slovenia; 3Jozef Stefan Institute, Ljubljana, Slovenia. 1481.Effects of Centraly Administered Arginine Vasopressin and Atrial Natriuretic Peptide on the Development of Brain Edema in Hyponatremic Rats Zsolt Vajda1, Michael Pedersen2, Tamás Dóczi3, Endre Sulyok4, Hans Stødkilde-Jørgensen2, Jørgen Frøkiaer1, Søren Nielsen1 1University of Aarhus, Aarhus, Denmark; 2Skejby University Hospital, Aarhus, Denmark; 3Medical School of Pécs, Hungary; 4County Children's Hospital, Pécs, Hungary. 1482.Bilateral Cortex Over Activation in a Unilateral Rodent Model of Parkinson´s Disease Galit Pelled1, Hagai Bergman2, Gadi Goelman1 1Hadassh Hebrew University Hospital, Jerusalem, Israel; 2Hadassah Medical School The Hebrew University, Jerusalem, Israel. 1483.Pharmacological Functional MRI of Psammomys Obesus Brain During Melatonin Stimulation Inbal Eti Biton1, Alina Neuman1, Nava Zisapel1, Yaniv Assaf1, Yoram Cohen1 1Tel Aviv University, Tel Aviv, Israel. 1484.High Resolution R2* Mapping of the Belgrade Rat Brain: Role of Divalent Metal Transporter 1(DMT1) in Regional Iron Content Jeff Bulte1, H. Zywicke1, Peter Van Gelderen1, M. D. Garrick2, K. G. Dolan2, J. R. Burdo3, J. R. Connor3, Joseph Frank1 1National Institutes of Health, Bethesda, MD, USA; 2Pennsylvania State University, Hershey, PA, USA; 3SUNY, Buffalo, NY, USA. 1485.MRS, Water and Tetramethylammonium Diffusion in a Rat Cortex after Traumatic Injury Ivan Vorisek1, Vít Herynek1, Martin Burian1, Milan Hajek1, Klaas Nicolay2, Eva Sykova3 1Institute of Experimental Medicine ASCR, Prague, Czech Republic; 2University Utrecht, Utrecht, Netherlands; 3Charles University, Prague, Czech Republic. 1486.In Vivo Imaging of Closed Head Injury in Mice: Automated Analysis Can Document Evidence for the Degree of Recovery Induced by COP-1 Immunization Uri Nevo1, Jonathan Kipnis2, Esther Shohami3, Solange Akselrod1, Michal Schwartz2 1Tel Aviv University, Tel-Aviv, Israel; 2The Weizmann Institute of Science, Rechovot, Israel; 3The Hebrew University, Jerusalem, Israel. 1487.In Vivo Neuro MRI Microsocopy of Transgenic Mice Overexpressing a Constitutively Active Human Glycogen Synthase Kinase-3b (GSK-3b). M Verhoye1, K Spittaels2, C Van den Haute2, K Bruynseels2, F Van Leuven2, A Van der Linden1 1University of Antwerp, Antwerp, Belgium; 2Flemish Institute for Biotechnology (VIB), KUL, Leuven, Belgium. 1488.Effects of Ketamine and Ketamine-Xylazine Anesthesia on Cerebral Blood Flow in Rat Observed Using Arterial Spin Tagging Perfusion Imaging Hao Lei1, Casmier I. Nwaigwe1, Heather Williams1, Jeffrey F. Dunn1 1Dartmouth Medical School, Hanover, NH, USA. 1489.Dynamic Registration of High Resolution 3-D images from Mouse Brain. Jean-Philippe Galons1, Alex I. Veress2, Jingyu Guo1, Leena Peltonen3, Lewis L. Lanier4, Jeffrey A. Weiss2, Robert Gillies1 1University of Arizona, Tucson, AZ, USA; 2University of Utah, Salt Lake City, UT, USA; 3UCLA, Los Angeles, CA, USA; 4University of California, San Francisco, San Francisco, CA, USA. 1490.Integrated T1-T2 Imaging of Water Compartition in Nerve In Vivo Mark D. Does1, John C. Gore1 1Yale University, School of Medicine, New Haven, CT, USA. 1491.MRI Detection of Cerebral Perfusion and Oxygenation Changes in Pig Brain using Intermolecular Multiple-Quantum Coherences Margaret Aranda1, Louis-S. Bouchard2, Rahim Rizi1, Ali Asaii1, Mounir Fertikh1, Mitchell D. Schnall1, Warren S. Warren2 1University of Pennsylvania Medical Center, Philadelphia, PA, USA; 2Princeton University, Princeton, NJ, USA. 1492.Functional MRI of Rat Olfactory Glomerulae: Mapping a Single Neuronal Unit Ikuhiro Kida1, Fahmeed Hyder1, Fuqiang Xu1, Robert Shulman1 1Yale University, New Haven, CT, USA. 1493.In Vivo 3D Imaging of the Rat Visual Pathway Using Mn2+ as a Tract Tracer Takashi Watanabe1, Thomas Michaelis1, Jens Frahm1 1Biomed NMR Forschungs GmbH, MPI fur Biophysikalische Chemie, Gottingen, Germany. Brain Diffusion Hall 4 Wednesday: 13:30 - 15:30 1494.Neuro-Beçhet´s Disease - Assessment with Isotropic Diffusion-Weighted Imaging Akira Kunimatsu1, Osamu Abe2, Toshiyuki Okubo, Naoto Hayashi, Harushi Mori, Shigeki Aoki, Kuni Ohtomo 1University of Tokyo, Branch Hospital of the University of Tokyo, Tokyo, Japan; 2Faculty of Medicine, Tokyo, Japan. 1495.Diffusion in Acute Intoxicated Human Brain Li Huang1, Si-Run Liu1, Guang Cao2 11st Affiliated Hospital, Jinan University Medical College, Guangzhou, Guangdong China; 2GE Medical Systems, Hong Kong, China; 1496.Diffusion MR Imaging of White Matter Injury in Rabbit Neonates after In Utero Hypoxia-Ischemia Brian C. Tom1, Palamadai N. Venkatasubramanian1, Reza Pouremad1, Sidhartha Tan1, Alice M. Wyrwicz1 1Evanston Northwestern Healthcare, Evanston, IL, USA. 1497.Average Models of Diffusion Maps in Normal Elderly Subjects and Patients with Alzheimers Disease Andrew Janke1, Stephen E. Rose1, Jonathan Chalk1, Derek Jones2, Wendy Strugnell3, David Doddrell1, James Semple4 1University of Queensland, Brisbane, Queensland, Australia; 2Leicester Royal Infirmary, University of Leicester, Leicester, England, UK; 3Princess Alexandra Hospital, Brisbane, Queensland, Australia; 4Smithkline Beecham Pharmaceuticals, Cambridge, England, UK. 1498.Normal Aging in the Central Nervous System: Quantitative Diffusion-tensor Analysis Using MR Imaging Osamu Abe1, Yoshiro Satake, Yukichika Kikuya, Hiroki Koyanagi, Haruyasu Yamada1, Okubo Toshiyuki2, Akira Kunimatsu3, Takeharu Yoshikawa4, Harushi Mori, Naoto Hayashi, Shigeki Aoki, Hiroyuki Kabasawa5, Yoshiyuki Takahashi5, Kuni Ohtomo 1University of Tokyo, Graduate School of Medicine, Tokyo Japan; 2Yamanashi Medical University, Japan; 3University of Tokyo, Branch Hospital of the University of Tokyo, Tokyo, Japan; 4Tokyo University, Tokyo Japan; 5GE Yokogawa Medical Systems, Tokyo. Japan. 1499.Diffusion Tensor Imaging and Magnetic Resonance Spectroscopy Studies of Schizophrenics and Controls R. Steel1, Mark Bastin2, S. McConnell2, Ian Marshall2, D. Cunningham-Owens2, Stephen Macgregor Lawrie2, Eve C. Johnstone2, J. J. Best2 1University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK; 2University of Edinburgh, Edinburgh, Scotland, UK. 1500.Diffusion Tensor Imaging for Severe Head Injury Tsukasa Nagaoka1, Hideaki Akimoto, Yoji Tanaka2, Naoyuki Miyasaka2, Kikuo Ohno2 1Tokyo Medical and Dental University and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; 2Tokyo Medical and Dental University, Tokyo Japan. 1501.An MRI and MTI Study of the Brain from Patients with Acute Disseminated Encephalomyelitis Matilde Inglese1, Fabrizio Salvi2, Gianluigi Mancardi3, Massimo Filippi1 1H San Raffaele, Milan, Italy; 2University of Bologna, Bologna, Italy; 3University of Genoa, Genoa, Italy. 1502.Spatial Functional Distribution in the Corticospinal Tract at the Corona Radiata: A 3DAC Study Takashi Inoue1, Akira Ogawa1, Hiroaki Shimizu2, Kuniaki Ogasawara1, Takashi Yoshimoto3, Hiroyuki Kabasawa4 1Iwate Medical University, Morioka, Iwate Japan; 2Kohnan Hospital, Sendai, Miyagi Japan; 3Tohoku University School of Medicine, Sendai, Miyagi Japan; 4GE Medical Systems, Tokyo, Japan. 1503.Fast Marching Tractography in the Planning of Epilepsy Surgery Geoffrey Parker1, S. H. Eriksson1, Fergus Rugg-Gunn2, Gareth Barker3, Claudia Wheeler-Kingshott4, John Duncan5 1Institute of Neurology, London, England, UK; 2Institute of Neurology, National Society for Epilepsy, Gerrards Cross, England, UK; 3The National Hospital, Institute of Neurology, London, England, UK; 4Surrey, England, UK; 5University College London, London, England, UK. 1504.Diffusion Tensor Imaging in Fixed Brain Tissue David Guilfoyle1, Joseph A. Helpern2, Kelvin Lim1 1Nathan Kline Institute, Orangeburg, NY, USA; 2New York University, New York, NY, USA. 1505.Diffusion Tensor Imaging of White Matter Changes Adjacent to Intra-cranial Tumors Gerard Riedy1, Neeraj Chepuri1, Hong Li1, Yi-Fen Yen1 1Wake Forest University School of Medicine, Winston-Salem, NC, USA. 1506.Complementary Information of Symmetric Colour Encoded DTI Maps in Chronic White Matter Desease. Christina Rossmanith1, Jochen G. Hirsch1, Michael Hennerici1, Jochen Gaa1, Achim Gass1 1University Hospital Mannheim/University of Heidelberg Mannheim, Germany. 1507.Correlation of Diffusion Tensor Anisotropy Measures, T2-Relaxation Distributions and Myelin Water Content in Human White Matter Brain Burkhard Mädler1, Kenneth Whittall1, Alex MacKay1 1University of British Columbia, Vancouver, BC, Canada. 1508.Dependence of SNR and Spatial Resolution on the Accuracy of DTMRI in Defining Local Tract Orientations: Validated with Mn-enhanced Optic Tracts Ching-Po Lin1, Wen-Yih Isaac Tseng2, Jyh-Horng Chen1 1National Taiwan University, Taipei, Taiwan, ROC; 2National Taiwan University Medical College, Taipei, Taiwan. 1509.An Investigation of Functional and Anatomical Connectivity using Diffusion Tensor Imaging Martin Koch1, David G. Norris1, Margret Hund-Georgiadis1 1Max-Planck-Institute of Cognitive Neuroscience, Leipzig, Germany. Diffusion ADC and Tensor Analysis Hall 4 Wednesday: 13:30 - 15:30 1510.Developing a Quality Control Program for Diffusion Weighted Imaging. Ioannis Delakis1, Elizabeth Moore2, Janet De Wilde1, Martin Leach2 1Imperial College of Science, Technology and Medicine, University of London, MagNET, London, England, UK; 2Royal Marsden Hospital, Sutton, Surrey, England, UK. 1511.Effect of Magnetic Field Gradients Induced by Microvasculature on NMR Measurements of Diffusion Coefficient Valerij G. Kiselev1 1Freiburg University Hospital, Freiburg, Germany. 1512.Tissue Characterization with Chi2 Maps of Monoexponential Diffusion Signal Fits Hatsuho Mamata1, Ferenc Jolesz1, Robert Mulkern2, Stephan Maier1 1Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA; 2Harvard University, The Children's Hospital, Boston, MA, USA. 1513.High B Value Diffusion MR Imaging: A Comparison of Apparent Diffusion Coefficients (ADCs) Values Between Two-point and Multi-point Analyses Hitoshi Kubo1, Masayuki Maeda2, Kenichirou Yata3, Makoto Hayashi2, Hajime Sakuma2, Kan Takeda2 1The University of Tokushima, School of Medical Sciences, Tokushima, Tokushima, Japan; 2Mie University School of Medicine, Tsu, Mie, Japan; 3Akita Research Institute of Brain and Blood Vessels, Akita, Akita, Japan. 1514.Observation of Multi-Exponential Decaying Behavior on Diffusion-Weighted Images with High B Values: Effects of Neural Fiber Orientations and Selection of the Regions of Interest Wen-Chau Wu1, Kuo-Hiang Kao1, Ping-Hong Lai2, Cheng-Yu Chen3, Hsiao-Wen Chung1 1National Taiwan University, Taipei, Taiwan, ROC; 2Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC; 3TriService General Hospital, Taipei, Taiwan, ROC. 1515.ADC Measurements in a Rat Model with Compartmental Geometric Considerations at 3T Kevin Bennett1, R. W. Cox1, H. Lu1, Kathleen (Donahue) Schmainda1, R. Bennett1, James Hyde1 1Medical College of Wisconsin, Milwaukee, WI, USA. 1516.Feasibility of Measuring Axon Size in the Rat Spinal Cord by q-Space Imaging: Effects of Membrane Permeability and Cell Size Distribution Chih-Liang Chin1, Felix Wehrli1, Scott N. Hwang1, David Hackney1, Suzanne L. Wehrli2 1University of Pennsylvania, Philadelphia, PA USA; 2Children's Hospital of Pennsylvania, Philadelphia, PA, USA. 1517.MR Microscopy Studies of the Appearance of the Multiexponential Diffusion in a Rat Spinal Cord In Vitro. Wladyslaw Piotr Weglarz1, Andrzej Jasinski1, Joanna Pindel1, Dariusz Adamek2, Piotr Kulinowski1, Tomasz Skorka1 1H. Niewodniczanski Institute of Nuclear Physics, Kraków, Poland; 2Collegium Medicum, Jagiellonian University, Kraków, Poland. 1518.Diffusion MR Studies Characterize Axonal Degeneration and Dieback in the Injured Larval Sea Lamprey Spinal Cord Masaya Takahashi1, G. Zhang1, M. E. Selzer1, Felix Wehrli1, S. L. Wehrli2, David Hackney1 1University of Pennsylvania Medical Center, Philadelphia, PA, USA; 2Children's Hospital of Philadelphia, Philadelphia, PA, USA. 1519.Fiber-Tracking of Human Brainstem: Validity, Reproducibility, and Tract Properties Susumu Mori1, Bram Stieltjes1, Peter C. Van Zijl1, Godfrey D. Pearlson2, Meiyappan Solaiyappan2, Walter Erwin Kaufmann1 1Johns Hopkins University, School of Medicine, and F.M.Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, USA; 2Johns Hopkins University, School of Medicine, Baltimore, MD USA, 1520.An Algorithm for White Matter Connectivity in the Human Brain Using Projected Diffusion Tensor Distance Tetsuo Sato1, Khader Hasan2, Andrew Alexander2 1Nara Institute of Science and Technology, Ikoma, Japan; 2University of Utah, Salt Lake City, UT, USA. 1521.Limitations and Requirements of Diffusion Tensor Fibre-Tracking: Assessment using Simulations Jacques-Donald Tournier1, Fernando Calamante1, M. D. King1, David Gadian2, Alan Connelly3 1Institute of Child Health, London, England, UK; 2Institute of Child Health, Royal College of Surgeons, London, England, UK; 3Great Ormond Street Hospital for Children, London, England, UK. 1522.A Probabilistic Map Approach for the Analysis of DTI-based Fiber Tracking and its Application to White Matter Injuries Susumu Mori1, Christos Davatzikos2, Dongrong Xu2, Laura Amodei2, Kim Fredericksen1, Meiyappan Solaiyappan2, Peter C. Van Zijl1 1Johns Hopkins University, School of Medicine and F.M.Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, USA; 2Johns Hopkins University, School of Medicine, Baltimore, MD, USA. 1523.Two Directional Method to Identify White Matter Tracts for Patients with Brain Tumors Wen-Ching Liu1, Martin D. Ollenschleger1, Andrei I. Holodny1 1University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA. 1524.A Comparison of 'Goodness' Metrics for Use with Fast Marching Tractography Geoffrey Parker1 1Institute of Neurology, London, England, UK. 1525.Investigation of Spinal Cord Nervous Tracts using Diffusion Tensor Imaging in a Rat Model of Spinal Cord Injury. Andrzej Jasiñski1, Artur Krzyzak1, Joanna Pindel1, Dariusz Adamek2, Wladyslaw P. Weglarz1, Andrzej Urbanik2 1H.Niewodniczanski Institute of Nuclear Physics, Kraków, Poland; 2Medical College Jagiellonian University, Kraków, Poland. 1526.Decreased Diffusion Anisotropy of the Hippocampus in Schizophrenic Patients: Diffusion Tensor MR Study Haruyasu Yamada1, Osamu Abe2, Kiyoto Kasai1, Noriomi Kuroki1, Hidenori Yamasue1, Toshiyuki Okubo3, Takeharu Yoshikawa4, Naoto Hayashi1, Shigeki Aoki5, Hiroyuki Kabasawa6, Kuni Ohtomo1 1University of Tokyo, Tokyo, Japan; 2Faculty of Medicine, Tokyo, Japan; 3Yamanashi Medical University, Yamanashi Japan; 4Tokyo University, Tokyo, Tokyo Japan; 5University of Tokyo Branch Hospital, Tokyo, Japan; 6GE Yokogawa Medical Systems, Tokyo, Japan. 1527.Bootstrap Analysis of DT-MRI Tractography Techniques: Streamlines and Tensorlines Mariana Lazar1, Khader M. Hasan1, Andrew Alexander1 1University of Utah, Salt Lake City, UT, USA. 1528.Orientational Diffusion Reflects Fiber Structure within a Voxel Elisabeth Von Dem Hagen1, R. Mark Henkelman1 1University of Toronto, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada. 1529.Solving the Diffusion Equation for Fiber Tracking in the Living Human Brain Daniel Gembris1, Helmut Schumacher2, Dieter Suter3 1Research Center Jülich, Jülich, Germany, Institute of Medicine and 2Central Institute for Applied Mathematics; 3University of Dortmund, Dortmund, Germany. 1530.Tracking, Bundling and Quantitatively Characterizing In Vivo Neuronal Fiber Pathways Using Diffusion Tensor Magnetic Resonance Imaging Zhaohua Ding1, John C. Gore1, Adam W. Anderson1 1Yale University, School of Medicine, New Haven, CT, USA. 1531.Characterization of Anisotropy in High Angular Resolution Diffusion Weighted MRI Lawrence Frank1 1University of California, San Diego, VA Medical Center, San Diego, CA, USA. 1532.Automated White Matter Delineation Tools Based On Diffusion Tensor Imaging Kim Fredericksen1, Laura Amodei2, Walter Erwin Kaufmann1, Peter C. Van Zijl1, Godfrey D. Pearlson2, Susumu Mori1 1Johns Hopkins University, School of Medicine and F.M.Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, USA; 2Johns Hopkins University, School of Medicine, Baltimore, MD, USA. 1533.Reconstructing Three-Dimensional White Matter Tracts in the Human Brain Using the Level Set Approach Albert C.S. Chung1, Paul Armitage1, J. Alison Noble1, Michael Brady1 1University of Oxford, Oxford, England, UK. 1534.Visualizing White Matter Tract Directionality in Two-Dimension Chung-Yi Hong1, Sheng-Kwei Song2 1Emory University, School of Medicine, Atlanta, GA, USA; 2Washington University, St. Louis, MO, USA. 1535.A Continuous Tensor Field Approximation for DT-MRI Data Sinisa Pajevic1, Peter J. Basser1, Akram Aldroubi2 1National Institutes of Health, Bethesda, MD, USA; 2Vanderbilt University, Nashville, TN, USA. 1536.Independent Component Analysis Applied to Diffusion Tensor MRI K. Arfanakis1, D. Cordes1, V. Haughton1, J.D. Carew1, M.E. Meyerand1 1University of Wisconsin, Madison, WI, USA. 1537.Exploration of b-Space for Diffusion Tensor Imaging of Human Brain Ibrahim Elshafiey1, Ponnada Aswadha Narayana1 1University of Texas - Houston Health Science Center, Houston, TX,, USA. 1538.Improving Relative Anisotropy Measurement using Directional Correlation of Eigenvectors Shu-Wei Sun1, Sheng-Kwei Song2, Chung-Yi Hong3, Woei Chyn Chu1, Chen Chang4 1National Yang-Ming University, Taipei, Taiwan; 2Washington University, St. Louis, MO, USA; 3Emory University, Atlanta, GA, USA; 4Academia Sinica, Taipei, Taiwan. 1539.A Novel Propagator Approach for NMR Signal Attenuation Due to Anisotropic Diffusion under Various Magnetic Field Gradients Zhong Chen1, Guoxing Lin2, Jianhui Zhong1 1University of Rochester, Rochester, NY, USA; 2Xiamen University, Xiamen, Fujian, P.R. China, 1540.The Distribution of Currents Induced in the Brain by Magnetic Stimulation: A Finite Element Analysis Incorporating DT-MRI-derived Conductivity Data Pedro C Miranda1, Sinisa Pajevic2, Carlo Pierpaoli2, Mark Hallett2, Peter J. Basser2 1University of Lisbon, Lisbon, Portugal; 2National Institutes of Health, Bethesda, MD, USA. Diffusion MRI Acquisition Methods Hall 4 Wednesday: 13:30 - 15:30 1541.High Resolution Diffusion-Weighted Imaging with RAD-GRASE Arthur F. Gmitro1, Mitsuko Kono1, Rebecca J. Theilmann1, Maria I. Altbach1, Theodore P. Trouard1 1University of Arizona, Tuscon, AZ, USA. 1542.Optimization of Diffusion-Weighted Magnetic Resonance Images Acquired with Spin Echo or Stimulated Echo Spiral Pulse Sequences Blanca Zauscher1, Lawrence Frank2 1University of California, San Diego, La Jolla, CA, USA; 2University of California, San Diego, VA Medical Center, San Diego, CA, USA. 1543.A Method for Optimising the Diffusion-Weighting b-value and its Application to Human Brain Imaging Paul Armitage1 1University of Oxford, Oxford, England, UK. 1544.Magnetization Transfer Studies of the Fast and Slow Apparent Diffusion Coefficient (ADC) Components in the Human Brain Robert V Mulkern1, Sridhar Vajapeyam1, Stephan E Maier2 1Harvard Medical School, The Children's Hospital, Boston, MA, USA; 2Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. 1545.A Method to Enhance Apparent Diffusion by External Currents Kikuo Yamaguchi1, Masaki Sekino1, Norio Iriguchi1, Shoogo Ueno1 1Graduate School of Medicine, University of Tokyo, Tokyo Japan. 1546.Gibbs Ringing and Negative ADC Values Gareth Barker1, Geoffrey Parker2, Claudia Wheeler-Kingshott2 1The National Hospital, Inst. of Neurology, London, England, UK; 2Institute of Neurology, London, England, UK. 1547.A 3D Diffusion-Weighted Radial Fast Spin-Echo Sequence for Whole Brain Imaging with High Spatial Resolution Rebecca J. Theilmann1, Arthur F. Gmitro1, Maria I. Altbach1, Theodore P. Trouard1 1University of Arizona, Tucson, AZ, USA. 1548.Investigation of the Visual Pathways using Diffusion-Weighted PSIF Rebecca A Quest1, Donald W McRobbie1 1Imperial College, Charing Cross Hospital, London, UK. 1549.Application of Non-CPMG Fast-Spin-Echo Sequences to MR Diffusion Imaging Mark E. Bastin1, Patrick Le Roux2 1University of Edinburgh, Edinburgh, Scotland, UK; 2GE Medical Systems, Milwaukee, WI, USA. 1550.Diffusion Tensor Imaging at 1.5 T and 3.0 T Stefan Hunsche1, Mike Moseley2, Peter Stoeter1, Maj Hedehus2 1Institut für Neuroradiologie, Mainz, Germany; 2Stanford University, Stanford, CA, USA. 1551.Demonstration of Two Diffusion Components in the Human Brain with High b-Value Diffusion-Weighted Imaging. Jochen G. Hirsch1, Jochen Gaa1, Michael Hennerici1, Achim Gass1 1University Hospital Mannheim/University of Heidelberg, Mannheim, Germany. 1552.Two Dimensional Navigator Echo Correction in DWI: Assessment of the Use of Multiple Reacquisition at High b-Value David Atkinson1, Fernando Calamante2, Derek Hill1, Alan Connelly2 1Guy's Hospital, London, England, UK; 2Institute of Child Health, London, England, UK. 1553.Real-Time Navigator Quality Based Re-Acquisition Strategy Improves Reliability of Interleaved Diffusion Weighted Imaging at 3.0 Tesla Johan Van Den Brink1, Arianne Van Muiswinkel1, Michel Jurrissen1, Gerald Van Ensbergen1, Hans Jenniskens1, Henk Dingemans1, Rolf Lamerichs1, Fredy Visser1, Paul Folkers1 1Philips Medical Systems, Best, Netherlands. 1554.The Value of Diffusion-Weighted Imaging and ADC Maps in the Differential Diagnosis of Intracranial Tumors Niloufar Sadeghi1, Danielle Baleriaux1, Philippe David1, Thierry Metens1 1ULB-Erasme, Brussels, Belgium. 1555.An MRI Based Method for the Detection of Peri-Infarct Depolarizations (PIDs) in Acute Head Injury Kenneth Richard Revett1, Paul E. Summers2, Andrew Simmons3, Stuart J Hibbins1, Anthony J. Strong1 1King's College Hospital, King's College London, London, UK; 2King's College London, London, UK; 3Institute of Psychiatry, London, England, UK. 1556.Diffusion Tensor Imaging in Neonatal Post Hemorrhagic Hydrocephalus Petra Hüppi1, Brendan P. Murphy2, Stephan Maier3, Terrie E. Inder4, Gary Zientara3, Ferenc Jolesz3 1Hôpital des Enfants, Geneva, Switzerland; 2Harvard Medical School, Boston, MA, USA; 3Harvard University, Brigham and Women's Hospital, Boston, MA, USA; 4University of Otago, Harvard Medical School, Children's Hospital. 1557.A Navigated Steady-State Sequence for Diffusion Imaging Karla Miller1, Dwight G. Nishimura1, John M. Pauly1 1Stanford University, Stanford, CA, USA. Perfusion Methodology: Arterial Spin Labeling Hall 4 Thursday: 13:30 - 15:30 1558.Multislice Perfusion MRI Using Arterial Spin Labeling: Controlling for MTC Effects in Adiabatic Fast Passage Inversion Using Proximal Slab Selective Saturation Pulses Donald S. Williams1, Qing Ye1, Alan Koretsky2, Chien Ho1 1Carnegie Mellon University, Pittsburgh NMR Center, Pittsburgh, PA, USA; 2National Institutes of Health, Bethesda, MD, USA. 1559.Dynamic Spin Labeling Angiography in a Reduced FOV Carsten Warmuth1, Matthias Günther2 1Charité, Berlin, Germany; 2Deutsches Krebsforchungzentrum, Heidelberg, Germany. 1560.True FISP Sequences Applied for Data Recording in FAIR Perfusion Imaging Petros Martirosian1, Fritz Schick1, Uwe Klose1 1University of Tübingen, Tübingen, Germany. 1561.Multislice Online Quantitative Perfusion Imaging using FAIR Exempting Separate T1 Measurement (FAIREST) Jiongjiong Wang1, Geon-Ho Jahng1, Song Lai1 1University of Connecticut Health Center, Farmington, CT, USA. 1562.Improved Efficiency for Multi-slice Continuous Arterial Spin Labeling Using Time Varying Gradients David Alsop1 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 1563.A Method to Extend the Spatial Coverage of SPDI-CASL Perfusion MRI S. Lalith Talagala1, Emmanuel Barbier1, A. Kam2, Alan Koretsky1 1National Institutes of Health, Bethesda, MD, USA; 2University of Pittsburgh, Pittsburgh, PA, USA. 1564.Improved Subtraction by Adiabatic FAIR Perfusion Imaging Janneke Schepers1, Michael Garwood2, Boudewijn van der Sanden1, Klaas Nicolay1 1Utrecht University, Utrecht, The Netherlands; 2University of Minnesota, Minneapolis, MN, USA. 1565.Non-invasive Dynamic 3D Angiography with ITS-3D-FAIR Matthias Guenther1, Carsten Warmuth2, Lothar Schad1 1Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany; 2Charite Berlin, Berlin, Germany. 1566.FLOw Specific Suppression (FLOSS) Image Using a Flow-driven Adiabatic Pulse Sequence Tzu-Chen Yeh1, Hui-Cheng Cheng1, Jen-Chuen Hsieh1, Cheng-Yen Chang1, Low-Tone Ho1 1Taipei Veterans General Hospital, Taipei, Taiwan. 1567.Accounting for Partial Volume Effects in Perfusion Measurements using AST Techniques Patricia Figueiredo1, Yongyue Zhang1, Stephen Smith1, Peter Jezzard1 1University of Oxford, John Radcliffe Hospital, Oxford, UK. 1568.Double Adiabatic Inversion Efficiencies Measured In Vitro H. Michael Gach1, A. W. Kam1, S. Lalith Talagala2, E. D. Reid1 1University of Pittsburgh, Pittsburgh, PA, USA; 2National Institutes of Health, Bethesda, MD, USA. 1569.Test-Retest Stability with Continuous Arterial Spin Labeled (CASL) Perfusion MRI in Regional Measurement of Cerebral Blood Flow Thomas Frederick Floyd1, Joseph Maldjian1, Julio Gonzales-Atavales1, David Alsop1, John Alan Detre1 1University of Pennsylvania, Philadelphia, PA, USA. 1570.Practical Method of Quantifying Cerebral Blood Flow using Pulsed Arterial Spin Labeling --- Correlation with Cold Xenon-CT Measurements--- Tokunori Kimura1, Tomoyuki Iwai2, Kiyohiko Takahashi2, Takeshi Nozokido2, Takaaki Sato2, Isao Naito2 1Medical Systems R&D Center, Toshiba, Tochigi, Japan; 2Geriatrics Research Institute and Hospital, Gumma, Japan. 1571.Normal Cerebral Perfusion Changes over Time Measured Using Arterial Spin Labelling Laura Parkes1, Paul Stephen Tofts2 1Institute of Neurology, London, England, UK; 2University College London, Institute of Neurology, London, England, UK. 1572.Dynamic Monitoring of T2* and Perfusion Changes induced by Oxygen or Carbongen Breathing P. Schmitt1, M. Weigel1, Peter Jakob1, M. Kotas1, M. Flentje1, Axel Haase1 1University of Wurzburg, Wurzburg, Germany. 1573.Using Arterial Spin Tagging to Determine the Effect of Indomethacin on Cerebral Blood Flow and Carbon Dioxide Reactivity in Humans K S St. Lawrence1, F Q Ye1, B K Lewis1, J A Frank1, A C McLaughlin1 1National Institutes of Health, Bethesda, MD, USA. 1574.Single-Coil Arterial Spin-Tagging for Estimating Cerebral Blood Flow- an Experimental Concordance with Quantitative Autoradiography, Supported by a Theoretical Study of The James Ewing1, Ling Wei2, Robert A. Knight1, Yue Cao3, Swati Pawa1, Tavarekere Nagaraja1, Joseph Fenstermacher1 1Henry Ford Hospital, Detroit, MI, USA; 2Washington University, School of Medicine, St Louis, MO, USA; 3Michigan State University, College of Human Medicine, East Lansing, MI, USA. 1575.Cerebral Blood Flow in Rett Syndrome: Evaluation with Continuous Arterial Spin Labeling Xavier Golay1, Florian Eichler1, Peter B Barker1, Sakkubai Naidu2, Peter C. Van Zijl1 1F.M. Kirby Research Center, Kennedy Krieger Institute & Johns Hopkins University, Baltimore, MD, USA; 2Kennedy Krieger Institute, Baltimore, MD, USA. 1576.The Effect of Ordinary Coffee Consumption on Quantitative Cerebral Perfusion MR Imaging Aaron S. Field1, Yi-Fen Yen1, Jonathan H. Burdette1, Dixon Moody1 1Wake Forest University School of Medicine, Winston-Salem, NC, USA. Perfusion Methodology: Contrast Agents Hall 4 Thursday: 13:30 - 15:30 1577.Global Cerebral Blood Flow (gCBF) Measurement in Rat Using Injection of Dissolved Hyperpolarized 129Xe Guillaume Duhamel1, Philippe Choquet2, Emmanuelle Grillon1, Jean Louis Leviel1, Michel Decorps1, Anne Ziegler1, André Constantinesco2 1UM INSERM U438 / Université Joseph Fourier, Grenoble, France; 2Université Louis Pasteur, Strasbourg, France. 1578.Automatic Determination of the Arterial Input Function (AIF) in Dynamic Contrast-Enhanced MRI in Acute Stroke Timothy Carroll1, Howard Rowley1 1University of Wisconsin-Madison, Madison, WI, USA. 1579.Dependence of Estimation Errors on Mean Transit Time in Dynamic Susceptibility-Contrast MR Imaging: Further Investigation with Singular Value Decomposition Fu-Nien Wang1, Ing-Jye Huang1, Hsiao-Wen Chung1, Cheng-Yu Chen2 1National Taiwan University, Taipei, Taiwan ROC; 2Tri-Service General Hospital, Taipei, Taiwan ROC. 1580.Is Quantification of Bolus Tracking MRI Reliable without Deconvolution? Joanna Elizabeth Perthen1, Fernando Calamante1, M. D. King1, David Gadian2, Alan Connelly1 1University College London, Institute of Child Health, London, England UK; 2Institute of Child Health, Royal College of Surgeons, London, England, UK. 1581.The Equivalence of SVD and Fourier Deconvolution for Dynamic Susceptibility Contrast Analysis David Alsop1, Gottfried Schlaug1 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 1582.Measurement of Cerebral Blood Flow in MRI using a Nonparametric Deconvolution Technique with Energy Compensation. Claus Kiefer1, Marwan M El-Koussy1, Karl O. Lovblad2, Gerhard Schroth3 1University of Berne, Berne Switzerland; 2Inselspital, Bern, Switzerland; 3Inselspital, University Bern, Switzerland. 1583.Use of Training Data for Improved Model-Free Estimation of the Impulse Response in Dynamic MRI Studies Lars Hanson1, Jacob Marstrand1, Egill Rostrup1 1Hvidovre Hospital, Hvidovre, Denmark., Hvidovre Hospital, Copenhagen, Denmark; 1584.Quantitative Measurements of Cerebral Blood Volume Using the Steady State Method: Plasma vs. Total Blood Volume Azim Celik1, Weili Lin2 1General Electric, Waukesha, WI, USA; 2University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 1585.Simulation of Perfusion Parameters in Dynamic Susceptibility Contrast MRI Linda Andersson1, Freddy Ståhlberg1, Ronnie Wirestam1 1Lund University Hospital, Lund, Sweden. 1586.Does Contrast Based Perfusion Imaging Give the Right Answer in Pathological Tissue? A Monte Carlo Simulation Study Andrew Blamire1, Peter Styles1 1University of Oxford, Oxford, England, UK. 1587.A Method for Quantification of Cerebral Mean Transit Time Using Bolus Tracking Perfusion MRI Evan DeLucia-Deranja1, Alina Tudorica1, Clifford Patlak1, Haifang Li1, Wei Huang1, F. Hospod1, G. Newman1 1State University of New York at Stony Brook, Stony Brook, NY, USA. 1588.A Fitting Approach to the Simultaneous Assessment of Cerebral Blood Volume and Blood-Brain Barrier Breakdown Glyn Johnson1, Stephan Wetzel1, Soonmee Cha1 1New York University School of Medicine, New York, NY, USA. 1589.Bolus Perfusion Effects in the Cervical Spinal Cord Joshua S. Shimony1, Erbil Akbudak1, Caitlin C. Sweeney1, Thomas E. Conturo1 1Washington University School of Medicine, Mallinckrodt Institute of Radiology, Saint Louis, MO, USA. 1590.Assessment of Blood-Brain Barrier Integrity Using a Macromolecular Contrast Agent Ganghong Tian1, Guangping Dai1, Ursula I. Tuor1, Bo Xiang1, John Mark1, Roxanne Deslauriers1 1National Research Council, Winnipeg, Manitoba, Canada. 1591.Relationship Between Cerebral Perfusion and Internal Carotid Blood Flow Jacob Rorbech Marstrand1, E. Rostrup1, Sverre Rosenbaum1, Ellen Garde1, H. B. W. Larsson1 1Hvidovre University Hospital, Hvidovre, Denmark. 1592.Use of High Dimensional Non-Rigid Registration to Facilitate Tissue Classification in EPI-based Perfusion Data Christina Triantafyllou1, John Suckling2, Mike O'Sullivan3, David Lythgoe2, Hugh Markus3 1Hammersmith Hospital, London, England, UK; 2Guy's, King's and St Thomas' School of Medicine, London, England, UK; 3St. George's Medical School, London, England, UK. 1593.Dynamics of Ictal and Postictal Brain Perfusion and Diffusion Johannes Weber1, Andreas Hufnagel1, Guido Widman1, Arnd Doerfler1, Michael Forsting1 1University of Essen, Essen, Germany. 1594.Evidence of Damaged Periventricular Capillary Beds in Normal Pressure Hydrocephalus: A Bolus Tracking Experiment Robin Corkill1, Matthew Romney Garnett1, Andrew Blamire1, Balasubramanian Rajagopalan2, TAD Cadoux-Hudson3, Peter Styles1 1University of Oxford, John Radcliffe Hospital, Oxford, UK; 2Dept. of Radiological Sciences, Oklahoma City, OK, USA; 3University of Oxford, Oxford, UK. 1595.Quantitative Perfusion MRI and CO2 Reactivity Tests in Patients with a Symptomatic ICA Oclussion Matthias J.P. Van Osch1, Dirk R. Rutgers2, Max A. Viergever1, Jeroen Van Der Grond2 1Image Sciences Institute, AZU, Utrecht, Netherlands; 2Academic Hospital Utrecht/AZU, Utrecht, Netherlands. 1596.Perfusion and Diffusion Weighted MRI in Human Anterior Choroidal Artery Infarction Christian Matthias Kerskens1, Claudia Anett Doege1, Berenice Romero1, Peter Brunecker1, Arno Villringer1 1Humboldt University, Berlin, Germany. 1597.MR Perfusion Imaging in Childhood Moyamoya Syndrome: Relationship to Clinical Symptoms and Implications for Patient Management Fernando Calamante1, V. Ganesan1, Fenella Jane Kirkham2, W. Jan3, W. K. Chong3, David Gadian4, Alan Connelly3 1Institute of Child Health, London, England, UK; 2University College London, London, UK; 3Great Ormond St. Hospital for Children, London, England, UK; 4Institute of Child Health, Royal College of Surgeons, London, England, UK. 1598.Perfusion Quantification Using Gaussian Processes Irene Andersen1, A. Szymkowiak2, C. Rasmussen2, L. K. Hansen2, Jacob Rorbech Marstrand3, H. B.W. Larsson3 1Technical University of Denmark, Hvidovre Hospital, Hvidovre, Denmark; 2Technical University of Denmark, Hvidovre, Denmark; 3Hvidovre University Hospital, Hvidovre, Denmark. Perfusion: Clinical Applications Hall 4 Thursday: 13:30 - 15:30 1599.Perfusion-Weighted Imaging of Inter-ictal Temporal Lobe Epilepsy Using FAIR-HASTE Ho-Ling Liu1, Peter Kochunov2, Jinwen Hou2, Yonglin Pu2, Srikanth Mahankali2, Ching-Mei Feng2, Seong-Hwan Yee2, Yung-Liang Wan1, Peter T. Fox2, Jia-Hong Gao2 1Chang Gung University, Chang Gung Medical Center, Taoyuan, Taiwan; 2University of Texas Health Science Center, San Antonio, TX, USA. 1600.Quantitative Evaluation of Mean Transit Time Obtained with Perfusion MR Imaging: Compared to Xe-133 SPECT in Occlusive Carotid Disease Keiichi Kikuchi1, Kenya Murase2, Hitoshi Miki1, Teruhiko Shimizu1, Takanori Kikuchi1, Yoshifumi Sugawara1, Junpei Ikezoe1, Shiro Ohue1 1Ehime University School of Medicine, Onsengun, Ehime, Japan; 2Osaka University Medical School, Suita, Osaka Japan. 1601.Perfusion Imaging of Meningioma using Continuous Arterial Spin Labeling: Comparison with T2*-Weighted Dynamic Imaging Yoshio Koshimoto1, Hirohiko Kimura1, Hidemasa Uematsu1, Hirotsugu Kado1, Satoshi Muramoto1, Hiroki Yamada1, Yasutaka Kawamura1, Harumi Itoh1 1Fukui Medical University, Fukui, Japan. 1602.Vasodilatory Response to Acetazolamide in Patients with Internal Carotid Artery or Middle Cerebral Artery Stenosis: An Echo Planar Imaging – Dynamic Susceptibility Contrast – Enhenced MRI Study Chang-Shin Lee1, Cheng-Yu Chen1 1Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan ROC. 1603.Determination of Perfusion Changes in Brain Metastases Undergoing Stereotactic Radiotherapy using a Noninvasive Quantitative MRI Arterial Spin Labeling Technique Marc-André Weber1, Heinz-Peter Schlemmer1, Matthias Guenther1, Christoph Thilmann1, Matthias Lichy1, Jürgen Debus1, Ivan Zuna1, Lothar Schad1, Stefan Delorme1, Gerhard Van Kaick1 1German Cancer Research Center, Heidelberg, Germany. MRI Studies of CSF Hall 4 Monday: 14:00 - 16:00 1604.Normal Pressure Hydrocephalus: Preoperative Evaluation of the Effect of the Shunt Surgery with Phase-Contrast Cine MR Technique Pyeong-Ho Yoon1, Dong-Ik Kim2 1Severance Hospital, Seoul, Korea; 2Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. 1605.The Relationship between Flow-void Score and Stroke Volume Show on CSF Hydrodynamics Ming-Yen Chen1, Teng-Yi Huang1, Cheng-Yu Sandy Chen2, Hsiao-Wen Chung1 1National Taiwan University, Taipei, Taiwan, ROC; 2Tri-service General Hospital, Taipei, Taiwan, ROC. 1606.Influence of Respiration on Cerebrospinal Fluid Flow in Normal Elderly and Pathologic Conditions Sigrid Friese1, Tanja Gostic1, Christian Koenig1, Claudia Strik1, Uwe Klose1 1University of Tübingen, Tübingen, Germany. 1607.Quantification of CSF Circulation Volume in Healthy Adults using 2D CINE Phase Contrast MRI Teng-Yi Huang1, Ming-Yen Chen2, Hsiao-Wen Chung1, Cheng-Yu Chen3 1National Taiwan University, Taipei, Taiwan; 2Yuanpei Institute of Science and Technology, Hsin Chu, Taiwan; 3Tri-Service General Hospital, Taipei, Taiwan. Head and Neck MR Imaging Hall 4 Monday: 14:00 - 16:00 1608.Navigation at the Optic Nerve for Monitoring of Eye Movement Silvia Olt1, Peter Jakob1, T. Meigen2, Axel Haase1 1Universitat Wurzburg, Würzburg, Germany; 2Universitäts-Augenklinik Würzburg, Würzburg, Germany. 1609.Real-Time MR Imaging with Tagging for Tongue Motion Analysis During Speech Cengizhan Ozturk1, Maureen Stone2, Devrim Unay1, Andrew Lundberg3, Elliot McVeigh4 1Bogazici University, Bebek, Istanbul, Turkey; 2University of Maryland College Park, University of Maryland, Baltimore, MD, USA; 3University of Maryland School of Medicine, Baltimore, MD USA; 4National Institutes of Health, Bethesda, MD, USA. 1610.Measurement by MRI of Rabbit Eye Volume before and after D-mannitol Infusion Tomoko Sawada1, Kazutaka Kani1, Jiro Nakamura1, Shigehiro Morikawa1, Toshiro Inubushi1 1Shiga University of Medical Science, Seta, Ohtsu, Shiga, Japan. 1611.MR Fluoroscopic Assessment of the Upper Airway Morphology in Obstructive Sleep Apnea Syndrome(OSAS); Visualization of the Effect of Oral Splint, Nasal Bi-PAP Hiroshi Fukatsu1, Shinji Naganawa1, Takeo Ishigaki1, Akiko Noda1 1Nagoya University School of Medicine, Nagoya, Aichi Japan. 1612.Assessing the Effectiveness of Neck Restraints using Magnetic Resonance Imaging Sarah Wayte1, Richard Wellings1, Mathew Cook2, Tim Crane3, Jo Higgins2 1Walsgrave Hospital NHS Trust, Coventry, W Mids, UK; 2University of Warwick, UK; 3Birmingham Children's Hospital, UK. 1613.High-Resolution Inner Ear Imaging Using 3D Asymmetric Fully-Balanced Steady State Coherent Imaging Pulse Sequence Anthony T. Vu1 1GE Medical Systems, Milwaukee, WI, USA. 1614.Fast Recovery 3D-Fast Spin Echo Imaging of the Inner Ear at 3T Shinji Naganawa1, Tokiko Koshikawa1, Hiroshi Fukatsu1, Takeo Ishigaki1, Ikuo Aoki2, Ayako Ninomiya2 1Nagoya University School of Medicine, Nagoya, Japan; 2Toshiba Corporation, Tokyo, Japan. Spine MR Imaging Hall 4 Monday: 14:00 - 16:00 1615.Diffusion-weighted MR Imaging of the Spinal Cord Using a Half-Fourier Single-shot Fast Spin-echo Technique Kazuhiro Tsuchiya1, Shichiro Katase1, Ayako Yoshino1, Junichi Hachiya1, Hitoshi Kanazawa2, Kenji Yodo3 1Kyorim University, Tokyo, Japan; 2Toshiba Corporation, Minato-ku, Tokyo, Japan; 3Toshiba Medical Systems, Bunkyo-ku, Tokyo, Japan. 1616.The Hemodynamic Response in The Spinal Cord Saaussan Madi1, Adam Flanders1, Joseph I. Tracy1, Jonathan Nissanov2 1Thomas Jefferson University, Philadelphia, PA, USA; 2MCP Hahnemann University, Philadelphia, PA, USA. 1617.Diffusion Tensor Imaging of the Cervical Spinal Cord Lesion with Echo-Planar Sequence Toshiyuki Okubo1, Kiichi Ishigame1, Masaaki Hori1, Haruyasu Yamada2, Osamu Abe3, Shigeki Aoki4, Kuni Ohtomo4, Tsutomu Araki1, Hiroyuki Kabasawa5 1Yamanashi Medical University, Nakakoma-gun, Yamanashi, Japan; 2Department of Radiology, Bunkyo Ward, Japan; 3Faculty of Medicine, Tokyo, Japan; 4University of Tokyo, Faculty of Medicine, Tokyo, Japan; 5GE Yogawawa Medical Systems, Tokyo, Japan. 1618.Force-Signal Amplitude Relation in Spinal Cord BOLD Imaging Saaussan Madi1, Adam Flanders2, Simon Vinitski2, Gerald J Herbison2, Jonathan Nissanov3 1Drexel University, Philadelphia, PA USA; 2Thomas Jefferson University, Philadelphia, PA, USA; 3MCP Hahnemann University, Philadelphia, PA, USA. 1619.Water Diffusion in the Spinal Cord of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis P. N. Venkatasubramanian1, Brian C. Tom1, Alice M. Wyrwicz1 1Evanston Northwestern Healthcare, Evanston, IL, USA. 1620.Magnetic Resonance and Magnetization Transfer Imaging Correlates of Cervical Cord Pathology in Patients with Primary Progressive Multiple Sclerosis Giuseppe Santuccio1, Marco Rovaris1, Marco Bozzali1, Giancarlo Comi1, Massimo Filippi1 1IRCCS H San Raffaele, Milan, Italy. 1621.MRI of the Human Cervical Spinal Cord at 3 Tesla Jeff Korzan1, Zaki Taher1, Monica Gorassini1, Derek J Emery1, Christian Beaulieu1 1University of Alberta, Edmonton, Alberta, Canada. 1622.Dynamic Assessment of Blood-Spinal-Cord Barrier in Contusion Injured Rat Spinal Cords In Vivo Thomas H. Mareci1, X.S. Silver1, P.A. Patel1 1University of Florida, Gainesville, FL, USA. 1623.Prognostic Value of MRI in Spinal Cord Injury Ponnada Aswadha Narayana1, Russell Abbe1, Dejian Lai1, Mehmet Bilgen1 1University of Texas - Houston Health Science Center, Houston, TX, USA, 1624.Non-Lethal Disruption of the Axonal Cytoskeleton Alters Water Diffusion in Spinal Cord White Matter Timothy M. Shepherd1, Peter E. Thelwall1, Edward D. Wirth III1 1University of Florida Brain Institute, Gainesville, FL, USA. 1625.Spinal Arterio-Venous Malformations: Evaluation with 3-D Contrast-Enhanced Magnetic Resonance Angiography. James Meaney1, Jane Cullingworth1, Romhild Hoegeveen2, Daina Dambitis1, John Straitton1, Michael Nelson1, John Ridgway1, Aleksandra Radjenovic1 1The General Infirmary at Leeds, Leeds, England, UK; 2Philips Medical Systems, Best, The Netherlands. 1626.Diffusion-Weighted MR Imaging of Vertebral Bone Marrow: Differentiation of Degenerative Spines and Spondylitis Involving to Bone Marrow Adjacent to End Plates Woo Mok Byun1 1Namku, Taegu, Korea. 1627.Upper Thoracic-Spine Disc Disease in Cervical MR Imaging Luis Martí-Bonmatí1, Estanislao Arana2, Rosa Dosdá2, Enrique Mollá2 1Dr Peset University Hospital and Quiron Clinic, Valencia, Spain; 2Valencia, Spain. 1628.Cervical Spine Interfacetal Dislocations: Patterns of Disc and Ligament Injuries. John A. Carrino1, Mark Schweitzer1, William Morrison1, Adam Flanders1, Luke Madigan1, Alexander Vaccaro1 1Thomas Jefferson University, Philadelphia, PA, USA. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Elastography Hall 2 Tuesday: 13:30 - 15:30 Chairs: John B. Weaver Michael H. Buonocore 13:30 1629.A Novel Approach to Analyzing Magnetic Resonance Elastography Data: Simulation of Wave Images Ingolf Sack1, Gerd Buntkowsky2, Johannes Bernarding1, Thomas Tolxdorff1, Juergen Braun1 1Free University of Berlin, University Hospital Benjamin Franklin, Berlin Germany; 2Free University, Berlin, Germany. 13:40 1630.Comparative Performance of Inversion Algorithms for Magnetic Resonance Elastography Armando Manduca1, Travis E. Oliphant1, Alex Dresner1, James F. Greenleaf1, Richard L. Ehman1 1Mayo Clinic and Foundation, Rochester, MN, USA. 13:50 1631.Accounting for Three Dimensional Motion Effects in MR Harmonic Displacement Data Elijah Van Houten1, Keith D. Paulsen1, Michael I. Miga1, Francis E. Kennedy Jr.1, John B. Weaver2 1Dartmouth College, Hanover, NH, USA; 2Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. 14:00 1632.NMR Elasticity Imaging: Three-Dimensional Elasticity Reconstruction Model A.R. Skovoroda1, D.D. Steele2, M. O'donnell2, T.L. Chenevert2, S. Emelianov2 1Institute of Mathematical Problems of Biology, Pushchino, Russia; 2University of Michigan, Ann Arbor, MI, USA. 14:10 1633.Localized Detection of Phase Transitions in Agarose Gels using Magnetic Resonance Elastography Juergen Braun1, Ingolf Sack1, Johannes Bernarding1, Karl Juergen Wolf1, Thomas Tolxdorff1 1University Hospital Benjamin Franklin, Free University Berlin, Berlin, Germany. 14:20 1634.Finite Element Simulation of Propagating Shear Waves in a Bent Beam Verified with Magnetic Resonance Elastography Thomas Jenkyn1, Kai-nan An1, Kenton R Kaufman1, Richard Ehman1 1Mayo Clinic, Rochester, MN, USA. 14:30 1635.Characterization of an Electromagnetic Actuator for MR Elastography Kai Uffmann1, Claus Abicht2, Harald H. Quick1, Heinz Ulbrich2, Mark E. Ladd1 1University Hospital Essen, Essen, Germany; 2University of Essen, Essen, Germany; 14:40 1636.Phase Difference Encoding of Coherent Pathways for High Speed MR Elastography Roger Grimm1, John Rydberg1, Richard Ehman1 1Mayo Clinic, Rochester, MN, USA. 14:50 1637.Development of a Multi-echo Sequence for Static MR-Elastography Peter Siegler1, Jan M. Boese1, Lothar R. Schad1 1Deutsches Krebsforschungzentrum, Heidelberg, Germany. 15:00 1638.Initial Performance of Three Dimensional Steady State MR Elastography J.B Weaver1, Van Houten2, M. I. Miga2, F. E. Kennedy2, K. D. Paulsen2 1Dartmouth Medical Center, Dartmouth College, Lebanon, NH, USA; 2Dartmouth College, Hanover, NH, USA. 15:10 1639.Evaluation of Quantitative MR-Elastography Measurements Uwe Hamhaber1, Uwe Klose1, Frieder Grieshaber2, Joachim Nagel2 1University of Tübingen, Tübingen, Germany; 2University of Stuttgart, Stuttgart, Germany. 15:20 1640.A Constrained Breast Magnetic Resonance Elastography Technique: 3D Phantom Study Abbas Samani1, Jonathan Bishop1, Donald Plewes2 1University of Toronto, Toronto, ON Canada; 2University of Toronto, Sunnybrook & WCHSC, Toronto, ON, Canada. Elastography Hall 4 Wednesday: 13:30 - 15:30 1641.Validation of Phase Encoding Methods for Magnetic Resonance Elastography Michael H Buonocore1, Gina Belleau2 1University of California, Davis, Sacramento, CA, USA; 2University of California, Davis, Davis, CA, USA. 1642.Adaptive Estimation of Piece-wise Constant Shear Modulus for Magnetic Resonance Elastography Travis E. Oliphant1, Armando Manduca1, Alex Dresner1, Richard Ehman1, James Greenleaf1 1Mayo Clinic and Foundation, Rochester, MN, USA. 1643.MR-Elastography for the Detection of Lesions Induced by High Intensity Focused Ultrasound Jan Boese1, Peter Siegler1, Jurgen Jenne1, Ralf Rastert1, Ioannis Simiantonakis1, Lothar Schad1 1Deutsches Krebsforschungszentrum, Heidelberg, Germany. 1644.Reducing Acquisition Time for Repeated Phase Contrast Imaging John B. Weaver1, D. M. Healy, Jr.2, Elijah Van Houten3, Keith D. Paulsen3 1Dartmouth College, Lebanon, NH, USA; 2University of Maryland, Baltimore, MD, USA; 3Dartmouth College, Hanover, NH, USA. 1645.A System for Generating Either Transverse or Longitudinal Waves for MR Elastography Kai Uffmann1, Claus Abicht2, Harald H. Quick1, Heinz Ulbrich2, Jörg F. Debatin1, Mark E. Ladd1 1University Hospital Essen, Essen, Germany; 2University of Essen, Essen, Germany; 1646.A Signal/Noise Analysis of Magnetic Resonance Strain Imaging Jonathan Bishop1, Abbas Samani1, Donald Plewes2 1University of Toronto, Toronto, ON, Canada; 2University of Toronto, Sunnybrook & WCHSC, Toronto, ON, Canada. 1647.Fast Spin-Echo Magnetic Resonance Elastography of the Brain John Rydberg1, Roger Grimm1, Scott Kruse1, Joel Felmlee1, Paul McCracken1, Richard Ehman1 1Mayo Clinic, Rochester, MN, USA. 1648.MR Elastography of Fixed Human Brain Slices Geoffrey Ryon Dixon1, Alex Dresner1, Scott Kruse1, Richard Ehman1 1Mayo Clinic, Rochester, MN. USA. 1649.Motion Compensated Encoding for Static Displacement Elasticity Imaging Derek Steele1, Stanislav Emelianov1, A R Skovoroda2, Thomas L. Chenevert1 1University of Michigan, Ann Arbor, MI, USA; 2The Institute of Mathmetical Problems, Puschino, Russia. Non-Neuro Diffusion Hall 4 Wednesday: 13:30 - 15:30 1650.Diffusion Measurements Using Dipolar Demagnetizing Fields and Potential Applications Scott D. Kennedy1, Zhong Chen1, Jianhui Zhong1 1University of Rochester, Rochester, NY, USA. 1651.Measurement of Cell Size in Biological Tissue Using Diffusion-Weighted MRI Olaf Dietrich1, Sabine Heiland1, Klaus Sartor1 1University of Heidelberg Medical School, Heidelberg, Germany. 1652.Measurements of Surface-to-Volume Ratio in Biological Samples Using Oscillating Gradients Melanie Schachter1, Richard P. Kennan1, Mark D. Does1, Adam W. Anderson1, John C. Gore1 1Yale University, New Haven, CT, USA. 1653.MR Measurement of the Apparent Diffusional Water Permeability of the Xenopus Oocyte Plasma Membrane Jonathan V. Sehy1, Alison A. Banks2, Joseph J.H. Ackerman1, Jeffrey J. Neil3 1Washington University, St. Louis, MO, USA; 2Bowdoin College, Brunswick, ME, USA; 3St. Louis Children's Hospital, St. Louis, MO, USA. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Spectral Quantification Clyde Auditorium Wednesday: 13:30 - 15:30 Chairs: Truman R. Brown Dirk Van Ormondt 13:30 1654.Reassessment of the Apparent Equilibrium Constant of Creatine Kinase Reaction for Accurate In Vivo Assessment of [ADP] by 31P MRS in the Human Brain and Skeletal Muscle. Stefano Iotti1, Antonio Sabatini2, Alberto Vacca2, Chiara Frassineti3, Bruno Barbiroli1 1Università di Bologna, Bologna, Italy; 2Universita di Firenze, Firenze, Italy; 3Università di Modena e Reggio Emilia, Modena, Italy. 13:40 1655.Quantitation of Deoxy-Myoglobin in Skeletal Muscle: Reproducibility and Effects of Location and Disease Roland Kreis1, Michael Ith1, Iris Baumgartner2, Karin Bruegger1, Corinna Skjelsvik2, Bruno Jung1, Chris Boesch1 1University & Inselspital, Bern, Switzerland; 2Inselspital, Bern, Switzerland. 13:50 1656.Multivoxel Metabolic Rate Measurement in Human Brain Following Oral Administration of [1-13C] glucose with 2-T Highly Sensitive 13C-MRS System Kazuya Okamoto1, Hidehiro Watanabe1, Masaaki Umeda1, Masanori Oda2, Tomoyuki Kanamatsu2, Yasuzo Tsukada2, Akiko Matsumoto3, Taisuke Otsuki3 1Toshiba Medical Systems R&D Center, Otawara, Tochigi, Japan; 2Soka University, Hachioji, Tokyo, Japan; 3National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. 14:00 1657.Solvent Removal and Data Quantification in Proton MR Spectroscopy Using Time-Scale Method Hacene Serrai1, Lotfi Senhadji2, David Clayton3, Chun Zuo4, Robert Lenkinski1 1Beth Israel Deaconess Medical Center, Boston, MA, USA; 2Université Rennes1, Rennes, France; 3University of Pennsylvania, Philadelphia, PA, USA; 4Lexington, MA, USA. 14:10 1658.A New Time-Domain Frequency-Selective Quantification Algorithm Rocco Romano1, Stefania Camassa2, Claudia Pagano2, Andrea Motta3, Maria Teresa Santini4, Pietro Luigi Indovina2 1Istituto Nazionale per la Fisica della Materia, Naples, Italy; 2Università degli Studi di Napoli Federico II, Naples, Italy; 3Istituto per la Chimica di Molecole di Interesse Biologico, Naples, Italy; 4Istituto Superiore di Sanità, Rome, Italy. 14:20 1659.Parameterized Evaluation of Pathological Macromolecules in Proton MR Spectra of the Human Brain Uwe Seeger1, Irina Mader1, Uwe Klose1, Thomas Nägele1 1University of Tübingen, Tübingen, Germany. 14:30 1660.Wavelet Detection of Intracerebral Ethanol Frederick Shic1, Cat-Huong Nguy2, Brian Ross1 1Huntington Medical Research Institutes, Pasadena, CA, USA; 2Rudi Shulte Research Institute, Santa Barbara, CA, USA. 14:40 1661.Analysis of Quantitation Errors Due to Neglect of Chemical Exchange and T1 Variations when Correcting for Partial Saturation in Magnetic Resonance Spectroscopy: Theoretical and Experimental C. Galban1, R. G.S. Spencer1 1NIH/National Institute on Aging, Baltimore, MD, USA. 14:50 1662.Proton T1 and T2 Relaxation Times of Human Brain Metabolites at 3 Tesla Vladimír Mlynárik1, Stephan Gruber1, Ewald Moser1 1University of Vienna, Vienna, Austria. 15:00 1663.T1 Measurements of Phosphorus Metabolites at 4.1 Tesla in Brain and Skeletal Muscle by FLAP MRSI Steven D Buchthal1, Bradley Newcomer1, Jan A. Den Hollander1, Gerald M Pohost1 1University of Alabama at Birmingham, Birmingham, AL, USA. 15:10 1664.Enhancing Features in NMR Spectra for Pattern Recognition Radka Stoyanova1, Truman Brown1, John Lindon2, Andy Nicholls2, Jeremy Nicholson2 1Fox Chase Cancer Center, Philadelphia, PA, USA; 2Imperial College of Science, Technology & Medicine, London, UK. 15:20 1665.Classification of Brain Tumors Using 1H MRSI at an Echo Time of 272 msec in Combination with Linear Discriminant Analysis. Strategies to Improve the Correct Classification Rate. Fabien Szabo De Edelenyi1, François Estève1, Sylvie Grand1, Christoph Segebarth1, Christophe Rubin1, Michel Décorps1, Jean François Le Bas1, Virginie Lefournier1, Chantal Rémy1 1CHU Grenoble, Grenoble, France. Spectroscopic Quantitation Hall 4 Thursday: 13:30 - 15:30 1666.Kinetic Modeling of Phosphatidylcholine and Phosphatidylethanolamine Biosynthesis Using 13C-NMR Spectroscopy Mehdi Adinehzadeh1, Nicholas Reo2, Brent Foy2 1Wallace-Kettering Neuroscience Institute, Kettering, OH, USA; 2Wright State University, Dayton, OH, USA. 1667.1H Spectroscopy without Water Suppression: Removal of Sideband Modulations at Short TE Mark Elliott1, David Clayton2, Robert Lenkinski3 1University of Pennsylvania, Philadelphia, PA, USA; 2Stanford University, Stanford, CA, USA; 3Harvard University, Beth Israel Deaconess Medical Center, Boston, MA, USA. 1668.Spectral Editing: Use of a Selective Inversion Pulse in an Adiabatic Double Spin-Echo Sequence Manoj K. Sammi1, Jullie W. Pan2, Frank W Telang1, Nora D Volkow1, Hoby P Hetherington2 1Brookhaven National Laboratory, Upton, NY, USA; 2Albert Einstein College of Medicine, Bronx, NY, USA. 1669.Quantitation of Localized 31P Magnetic Resonance Spectra Based on the Reciprocity Principle Roland Kreis1, Johannes Slotboom1, Joachim Pietz2, Bruno Jung1, Chris Boesch1 1University & Inselspital, Bern, Switzerland; 2University Heidelberg, Heidelberg, Germany. 1670.Evaluation of Inversion Recovery Techniques for Recording Short Echo Time In Vivo Proton MR Spectra of Cerebral Low-Molecular-Weight Metabolites Zenon Starcuk Jr.1, Jaroslav Horky1, Zenon Starcuk1 1Academy of Sciences of the Czech Republic, Brno, Czech Republic. 1671.Effects of Imaging Pixel Misregistration on Serial 1H MR Spectroscopy of Focal Brain Pathologies Belinda S.Y. Li1, Robert I. Grossman2, Oded Gonen1 1Fox Chase Cancer Center, Philadelphia, PA, USA; 2University of Pennsylvania, Philadelphia, PA, USA. 1672.Now It Can Be Said: N-Acetylaspartate IS a Neuronal Marker --- A HRMAS Proton MR Spectroscopy and Stereology Study Leo Ling Cheng1, K. Newell1, R. Le1, B. T. Hyman1, R. G. Gonzalez1 1Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. 1673.Identification of Pathogenic Fungi by a Statistical Classification Strategy of 1H MR Spectra Uwe Himmelreich1, Ray Somorjai2, Brion Dolenko2, Carolyn Mountford1, Tania Sorrell1 1University of Sydney, Sydney, NSW, Australia; 2National Research Council, Winnipeg, MB, Canada. 1674.Quantification of a Single MR Spectrum by Principal Component Analysis (SPCA) Jae-Hwan Kwag1, Stephen Pickup2, Wei Chen1 1University of Minnesota Medical School, Minneapolis, MN, USA; 2University of Pennsylvania, Philadelphia, PA, USA. 1675.Magnetization Transfer Rates and Diffusion Coefficients in Human Bone Marrow Differ Significantly between Healthy Volunteers and Patients with Hematological Diseases - A 1H-MRS Study Jürgen Machann1, Klaus Brechtel1, Hermann Einsele1, Philippe L. Pereira1, Otto Lutz2, Claus D. Claussen1, Fritz Schick1 1Universität Tübingen, Tübingen, Germany; 2Eberhard-Karls-Universität, Tübingen, Germany. 1676.Reproducibility of 2D Localized COSY In Vitro Nader Binesh1, Kenneth Yue1, M.Albert Thomas1 1University of California, Los Angeles, Los Angeles, CA, USA. 1677.Spectral Quantification by a Modified Principal Component Analysis (MPCA) Jae-Hwan Kwag1, Xiao-Hong Zhu1, Wei Chen1 1University of Minnesota, Minneapolis, MN, USA. 1678.Optimised Processing to Enhance Time-Reduced Acquisition: The OPERA House Window Function for 2D NMR Spectroscopy of Biological Samples June Q.Y. Watzl1, Edward J. Delikatny1 1University of Sydney, Sydney, NSW, Australia. 1679.Statistical Analysis of Human Cerebrospinal Fluid 1H NMR Spectra Beata Toczylowska1, Adam Jozwik2, Katarzyna Kierul3 1Institute of Biocybernetics & Biomedical Engineering, Institute of Biochemistry & Biophysics, Warsaw, Poland; 2Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland; 3Medical University Hospital, Warsaw, Poland. 1680.Potential Pitfalls when Using Prior Knowledge in Time-Domain Quantification of 31P NMR Spectra Oliver Schmidt1, Michael Bunse1, Wulf-Ingo Jung1, Günther J. Dietze1, Otto Lutz2 1Max Grundig Clinic, Bühl, Germany; 2University of Tübingen, Tübingen, Germany. 1681.Metabolite Quantitation Reproducibility in Serial 1H-MRSI Studies of Human Brain Using a Stereotactic Immobilization/Repositioning Frame Andrei Z. Damyanovich1, Satish M. Jaywant1, Warren Mason1, David J. Mikulis2 1University of Toronto, and Princess Margaret Hospital, Toronto, ON, Canada; 2University of Toronto, and The Toronto Western Hospital, Toronto, ON, Canada. 1682.Automatic Frequency Alignment for Magnetic Resonance Spectra -- Algorithms and Comparison Sabine Van Huffel1, Yu Wang1, Leentje Vanhamme1, Paul Van Hecke2 1Katholieke Universiteit Leuven, Heverlee, Belgium; 2Katholieke Universiteit Leuven, Leuven, Belgium. 1683.Advanced Computational Methods for Brain Tumour Discrimination with MRS Y. Huang1, YYB Lee1, PJG Lisboa1, W. El-Deredy1, C Arus2 1John Moores University, Liverpool, UK; 2U. Autonoma Barcelona, Barcelona, Spain. 1684.In Vivo Metabolite T2 Accurately Measured with Large TE Range Elana Brief1, Kenneth P Whittall2, David Li2, Alex MacKay1 1University of British Columbia, Vancouver, BC, Canada; 2University of British Columbia, Vancouver Hospital and HSC, Vancouver, BC, Canada. 1685.Quantification of NAA, Creatine and Choline in Turbo Spectroscopic Imaging MR Data using Time Domain Fitting Procedures H.J.A. in 't Zandt1, P. Van Hecke1, R. Lamerichs2, L. Vanhamme1, S. Van Huffel1 1Katholieke Universiteit Leuven, Leuven, Belgium; 2Philips Medical Systems, Best, Netherlands. MRS Localization and Processing Hall 4 Thursday: 13:30 - 15:30 1686.Characterization of Gradient-Induced Signal Modulations: Implications for Proton MR Spectroscopic Methods David Clayton1, M. A. Elliott1, John Leigh1, Robert Lenkinski2 1University of Pennsylvania, Philadelphia, PA, USA; 2Harvard University, Beth Israel Deaconess Medical Center, Boston, MA, USA. 1687.Spatial Interference Effects Due to Scalar Coupling Interactions in STEAM E. Wrenn Wooten1, Dmitriy A. Yablonskiy1, Joseph J.H. Ackerman1 1Washington University, St. Louis, MO, USA. 1688.Removal of Gradient Induced Frequency Modulations in Localized Proton Spectroscopy Hacene Serrai1, David Clayton2, Lotfi Senhadji3, Chun Zuo4, Robert Lenkinski1 1Beth Israel Deaconess Medical Center, Boston, MA, USA; 2University of Pennsylvania, Philadelphia, PA, USA; 3Université Rennes1, Rennes, France; 4Lexington, MA, USA. 1689.Differentiation of Choline and Ethanolamine in Human Brain Noriaki Hattori1, M. Albert Thomas2, S. Naruse3, M. Umeda3, C. Tanaka3, N. Inoue3, M. Fukunaga3, Y. Someya3, T. Sawada3 1Osaka & Kyoto Prefectural University of Medicine, Suita, Osaka, Japan; 2University of California Los Angeles, Los Angeles, CA, USA; 3Osaka & Kyoto Prefectural University of Medicine, Kyoto, Japan. 1690.Advanced Proton Echo Planar Spectroscopic Imaging with Highly Effective Outer Volume Archie Chu1, Jeffry Alger2, Gregory J. Moore1, Stefan Posse1 1Wayne State University, Detroit, MI, USA; 2University of California, Los Angeles, Los Angeles, CA, USA. 1691.Combination of Multi-Slice and 3D Acquisition in Spectroscopic Imaging to Improve Resolution Jan Willem C. Van Der Veen1, Daniel R. Weinberger2, Joseph Frank3, Jeff Duyn3 1National Institutes of Health, Delft University of Technology, Bethesda, MD, USA; 2Delft University of Technology, Delft, The Netherlands; 3National Institutes of Health, Bethesda, MD, USA. 1692.Rapid Spiral Chemical Shift Imaging at 3T E. Adalsteinsson1, D. M. Spielman1 1Stanford University, Stanford, CA, USA. 1693.Fast Spectroscopic Imaging of the Human Brain at 3 Tesla Rolf Lamerichs1, Paul Harvey1, Paul Folkers1, Dieter Meier2, Peter Boesiger2 1Philips Medical Systems, Best, Netherlands; 2Institute of Biomedical Engineering, Zürich, Switzerland. 1694.Optimizing 1H MRSI of the Human Brain at 4.1 Tesla Jan A den Hollander1, Du Fei1, Steven D Buchthal1 1University of Alabama at Birmingham, Birmingham, AL, USA. 1695.Processing Strategy for Sensitivity-Encoded Spectroscopy Imaging Xiaoli Zhao1, Robert Prost1, Zhu Li1, Shi-Jiang Li1 1Medical College of Wisconsin, Milwaukee, WI, USA. 1696.Data Acquisition Efficiency in 'Turbo' Spectroscopic Imaging: Use of Time Domain Processing, Prior Knowledge, and Linear Prediction to reduce Acquisition Times S. R. Williams1, P. F. Tokarczuk1 1University of Manchester, Manchester, UK. 1697.Assessment of 3D 1H Echo-Planar Spectroscopic Imaging Using Automated Spectral Analysis Andreas Ebel1, Andrew A. Maudsley1 1VA Medical Center, San Francisco and University of California, San Francisco, CA, USA. MRS Methodology Hall 4 Thursday: 13:30 - 15:30 1698.Water-Suppressing Band-Selective Excitation and Refocusing Pulses for 1H CSI Optimized by Simulated Annealing Jun Shen1 1Nathan Kline Institute, Orangeburg, NY, USA. 1699.Analysis of Multiple Inversion Recovery as a Water Suppression Method for 1H Magnetic Resonance Spectroscopy Jack Knight-Scott1, Vu M. Mai2, Andreana Petrova Haley1 1University of Virginia, Charlottesville, VA, USA; 2Evanston Hospital, Evanston, IL, USA. 1700.Effects of Poor Shimming on Quantitative Measurement of Metabolite Levels by 1H MR Spectroscopy Hyeon-Man Baik1, Bo-Young Choe1, Tae-Suk Suh1, Hyoung-Koo Lee1, Kyung-Sub Shinn1 1Catholic University of Korea, Seoul, Korea. 1701.In Vivo Brain pH Mapping Using 19x19 Voxels 1H MR Spectroscopic Imaging of the Down Field Region Martin Büchert1, J O'Neill1, Peter Vermathen2, Andrew A. Maudsley1 1University of California, San Francisco, VA Medical Center, San Francisco, CA, USA; 2Inselspital and University, Bern, Switzerland. 1702.13C NMR Isotopomer Distribution Analysis: A Method for Measuring the Synthesis of Biological Polymers Caterina Puccetti1, Tommaso Aureli2, Cesare Manetti1, Filippo Conti1 1Università 'La Sapienza', Roma, Italy; 2Sigma-Tau S.p.A. Research Labs, Pomezia Italy. 1703.Effect of Superparamagnetic and Paramagnetic Contrast Agents on T1 and T2 Relaxation of Creatine and Choline Mari H.B. Hjelstuen1, Henrik W. Anthonsen1, Inger Johanne Bakken1, Ingrid S. Gribbestad1, Atle Bjornerud2, Tore Skjetne1 1SINTEF Unimed MR-Center, Trondheim, Norway; 2Nycomed Imaging AS, Oslo, Norway. 1704.Probing Dosimeter Gels With 129Xe NMR James M Joers1, Peter Marc Fong1, John C. Gore1 1Yale University, New Haven, CT, USA. 1705.Electrophoretic CSI Using Deuterated Acetonitrile D. Elverfeldt1, J. Heinze1, Jürgen Hennig1 1University of Freiburg, Freiburg, Germany. 1706.A Neural Network Method for Automated Detection of J-edited GABA Michael I. Appel1, Douglas L. Rothman1, Robin A. de Graaf1, Graeme F. Mason1 1Yale University School of Medicine, New Haven, CT, USA. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Data Processing Issues in fMRI Hall 2 Wednesday: 13:30 - 15:30 Chairs: Oliver Speck Nick Lange 13:30 1707.Are Semi-Random Designs Better than Random Designs for Event-Related fMRI? Thomas Liu1, Eric Wong1, Lawrence Frank2, Richard Buxton3 1University of California, San Diego, Thornton Hospital, La Jolla, CA USA; 2University of California, San Diego, VA Medical Center, San Diego, CA, USA; 3University of California, San Diego, Magnetic Resonance Institute, San Diego, CA, USA. 13:40 1708.Localization of the Resting State Vasomotor Fluctuation with FFT, Cross Correlation, Principal Component and Independent Component Analysis of fMRI data. Vesa Kiviniemi1, Juha-Pekka Kantola1, Bharat Biswal2, Jukka Jauhiainen3, Aapo Hyvarinen4, Osmo Tervonen3 1University of Oulu, Oulu, Finland; 2Medical College of Wisconsin, Milwaukee, WI, USA; 3Oulu University Hospital, Oulu, Finland; 4Helsinki University of Technology, Helsinki, Finland. 13:50 1709.Mapping Transient, Randomly Occurring Neuropsychological Events Using Independent Component Analysis Hong Gu1, Wolfgang Engelien1, Emily Stern1, Yihong Yang1, David A. Silbersweig1, Wang Zhan1, Hanhua Fang1 1Cornell University Medical College, New York, NY, USA. 14:00 1710.The Relationship of BOLD, CBF and CBV Changes Induced by Hypercapnia During the Transient-State in Rat Brain Detected by Functional MRI Gaohong Wu1, Feng Luo1, Zhu Li1, Shi-Jiang Li1, Xiao Zhao1 1Medical College of Wisconsin, Milwaukee, WI, USA. 14:10 1711.Fixed Effect Model for Analyzing the Spatiotemporal Brain Jagath Rajapakse1, Jayasanka Piyaratna1 1Nanyang Technological University, Singapore. 14:20 1712.Spatiotemporal Dynamic fMRI in a Digit Ordering Working Memory Task Witaya Sungkarat1 1University of Southern California, Los Angeles, CA, USA. 14:30 1713.A Dynamically Weighted Time Delay Neural Network for Modeling fMRI Response Vinod Venkatraman1, Jagath Rajapakse1 1Nanyang Technological University, Singapore. 14:40 1714.Hybrid Independent Component Analysis of fMRI Data in the Frequency Domain J.D. Carew1, V.M. Haughton1, C. Moritz1, B. Rogers1, M.E. Meyerand1 1University of Wisconsin, Madison, WI, USA. 14:50 1715.Enhancing Functional Paradigm Specific Independent Components with the AFRICA Technique Stephen Laconte1, Shing-Chung Ngan1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 15:00 1716.Characterizing Phase Synchronization in Whole-Brain fMRI Activation Angela R. Laird1, John Carew1, Baxter Rogers1, Konstantinos Arfanakis1, Chad Moritz2, M. Meyerand1 1University of Wisconsin-Madison, Madison, WI, USA; 2University of Wisconsin Colleges, Cross Plains, WI, USA. 15:10 1717.Long and Short Term Reproducibility of Various Methods of Quantifying Brain Activation Using fMRI Kyung Peck1, Alan Sunderland1, Penny Gowland1, Richard Bowtell1 1University of Nottingham, Nottingham, England, UK. 15:20 1718.A Comprehensive Approach to Estimating Test-Retest Reliability in fMRI Steven R Roys1, Ranjan Maitra2, Rao P Gullapalli1 1University of Maryland, Baltimore, Baltimore, MD, USA; 2University of Maryland Baltimore County, Baltimore, MD, USA. fMRI Data Analysis Hall 4 Thursday: 13:30 - 15:30 1719.Biased Activation Onset Times in Segmented-EPI fMRI Series Corrected by Fourier Interpolation in the K-space Pierre-Francois Van De Moortele1, Amir Shmuel1, Josef Pfeuffer1, Essa Yacoub1, Kamil Ugurbil1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 1720.PCA for Mapping Time Delays in the Transient Response from Functional MRI Studies Anders H. Andersen1, William S. Rayens1, Robin Greene-Avison1, Creed Pettigrew1, Joseph Berger1, Malcolm J. Avison1 1University of Kentucky, Lexington, KY USA. 1721.Phase Synchronization: A Method of Detecting Functional Connectivity Angela Laird1, John Carew1, Baxter Rogers1, Konstantinos Arfanakis1, Chad Moritz2, M. Meyerand1 1University of Wisconsin-Madison, Madison, WI, USA; 2University of Wisconsin Colleges, Cross Plains, WI, USA. 1722.Temporal Shift Sensitivity of Event Related FMRI Luis Hernandez1, Douglas Noll1, David Thomas Badre2 1University of Michigan, Ann Arbor, MI, USA; 2Massachusetts Institiute of Technology, Boston, MA, USA. 1723.Optimal Temporal Resolution in Single Event fMRI B. Dilharreguy1, R. A. Jones2, Chrit Moonen3 1Université Bordeaux, Bordeaux, France; 2Université Victor Segalen, Bordeaux, France; 3Université Victor Segalen Bordeaux 2, Bordeaux, France. 1724.Temporal Resolution Assessment of Simulated Event-related Functional MRI using ANOVA Jian-chuan Chen1, Ho-Ling Liu1, Yau-yau Wai1, Yung-Liang Wan1 1Chang Gung Memorial Hospital, Taiwan, ROC. 1725.The Temporal Constancy of Resting Brain Activity Implicated in fMRI Studies Guojun He1, Jintong Mao1, Andrea S. Perry1, Jia-Hong Gao2, Peter Fox2, Yijun Liu1 1University of Florida, Gainesville, FL, USA; 2University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. 1726.Frequency Domain Ranking Independent Component Analysis of a fMRI Complex Motor Paradigm Chad Moritz1, JD Carew2, VM Haughton2, ME Meyerand2 1University of Wisconsin Colleges, Cross Plains, WI, USA; 2University of Wisconsin, Madison, WI, USA. 1727.Modeling Hemodynamic Response in fMRI Using Wavelet Analysis Yu Chen1, Shing-Chung Ngan1, Stephen Laconte1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 1728.Extraction of Transient BOLD Responses Associated with Cortical Spreading Depression using Spatial ICA Chaiyapoj Netsiri1, Daniel P Bradley2, Justin M Smith2, Martin I Smith3, Nikolaos Papadakis1, Adrian Carpenter1, Laurance Hall2, Andrew A Parsons4, Christopher Huang2, Michael F James3 1University of Cambridge, Addenbrooke's Hospital, Cambridge, England, UK; 2University of Cambridge, Cambridge, England, UK; 3SmithKline Beecham Pharmaceuticals, Essex, England, UK; 4SmithKline Beecham Pharmaceuticals, King of Prussia, PA, USA. 1729.Localization of Brain Alpha Activity by Functional MRI Using Independent Component Analysis Jeong-Won Jeong1, Tae-Seong Kim1, Manbir Singh1 1University of Southern California, Los Angeles, CA, USA. 1730.Comparison of Orthogonal and Independent Component Analysis on Dimension-Reduced fMRI Data in Patial Least Squares Framework Fa-Hsuan Lin1, Anthony R. McIntosh2, Thomas A. Zeffiro3, John Agnew3, John Belliveau1 1Massachusetts General Hospital, Charlestown, MA, USA; 2University of Toronto, Toronto, ON, Canada; 3Georgetown University Medical Center, Washington, DC, USA. 1731.Comparison of Hybrid Independent Component Analysis and Simple Regression of an Event-Related fMRI Experiment Baxter Rogers1, John Carew1, Michelle Quigley1, Angela Laird1, Konstantinos Arfanakis1, Chad Moritz2, M. Meyerand1 1University of Wisconsin-Madison, Madison, WI, USA; 2University of Wisconsin Colleges, Cross Plains, WI, USA. 1732.Bayesian Estimation of a Parameterized Hemodynamic Response Function in an Event-Related fMRI Experiment Kevin H. Knuth1, Babak Ardekani2, Joseph A. Helpern3 1Nathan Kline Institute, New York University Medical School, New York, NY, USA; 2The Nathan S. Kline Institute, Orangeburg, NY, USA; 3New York University, New York, NY, USA. 1733.Using Bayesian Analysis to Test the Linearity of the BOLD Response in Event-Related fMRI Jeff Kershaw1, Kenichi Kashikura1, Iwao Kanno2 1Japan Science and Technology Corporation (JST), Akita City, Japan; 2Research Institute for Brain & Blood Vessels, Akita City, Japan. 1734.Partial Least Squares for Balancing Variance Partitioning and Fixed-Effect Regression Models in fMRI Analysis Anders H. Andersen1, William S. Rayens1, Zhiming Zhang1, Charles D. Smith1, Don Gash1 1University of Kentucky, Lexington, KY, USA. 1735.Group Statistical Parametric Maps in Rat Pharmacological MRI Andrew Lowe1, Mark Symms2, Mohammed Shoaib3, Steve Williams3 1Institute of Neurology, London, England, UK; 2National Society for Epilepsy, Gerrards Cross, England, UK; 3Institute of Psychiatry, London, England, UK. 1736.An Optimised Permutation Test for fMRI Analysis Matthew Belmonte1, Deborah Yurgelun-Todd1 1McLean Hospital, Belmont, MA, USA. 1737.Should We Fit the Data to the Analysis Method? An In Vivo fMRI Study of the Spatio-temporal Heterogeneity of fMRI Data Richard Baumgartner1, Ray Somorjai1, Lawrence Ryner1 1National Research Council Canada, Winnipeg, MB, Canada. 1738.Regularised fMRI Signal Response Estimation in a Library of Orthonormal Bases C. J. Long1, E.T. Bullmore2, E.M. Brown3, V. Solo4, M.J. Brammer1 1Institute of Psychiatry, London, UK; 2University of Cambridge, Addenbrookes Hospital, Cambridge, UK, ; 3Massachusetts General Hospital, Boston, MA, USA; 4Macquarie University, Sydney, NSW, Australia. 1739.Local Clustering of Functional Magnetic Resonance Images in the Frequency Space Jatuporn Chinrungrueng1, Francois Meyer1 1University of Colorado at Boulder, Boulder, CO, USA. 1740.Spatially Connected Activation in fMRI at 3 Tesla: Influence on Somatotopy in Human Sensorimotor Cortex? Christian Windischberger1, Roland Beisteiner2, Vinod Edward2, Marcus Erdler2, Rupert Lanzenberger3, Ross Cunnington2, Bernhard Streibl2, Andreas Gartus2, Ewald Moser1 1Institute for Medical Physics, Vienna, Austria; 2University of Vienna, Vienna, Austria; 3University of Vienna and General Hospital, Vienna, Austria. 1741.A Significance Test for Clustering William Auffermann1, Shing-Chung Ngan1, Essa Yacoub1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 1742.fMRI Of Visual Perception: Networks Identified By SPM And Independent Component Analysis Vince Calhoun1, James Pekar2, Tulay Adali3, Godfrey D. Pearlson1 1Johns Hopkins University, Baltimore, MD, USA; 2Johns Hopkins University, Kennedy Krieger Institute, Baltimore, MD, USA; 3University of Maryland Baltimore County, Baltimore, MD, USA. 1743.A Category System to Test the Feasibility of BOLD fMRI Motor Map for Patients with Brain Tumors and Arteriovenous Malformations. Wen-Ching Liu1, Mathangi Thiagarajan1, Tzu-Lung Ho1, Andrew Kalnin1, Andrei Holodny1 1University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA. 1744.Validating a Simple "Open" Head Restraint for use in fMRI Cathy Nangini1, Emily Seto1, Abdel El-Rahmann1, Simon Graham1 1University of Toronto, Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada. 1745.fMRI and Concurrent EEG in Patients with Focal Epilepsy: Processing of EEG Signals for fMRI Analysis Goran Vucurevic1, Stephan Boor1, Rainer Boor2, Georg Kutschke2, Peter Stoeter1 1Institute for Neuroradiology, Mainz, Germany; 2Kinder Klinik, Mainz, Germany. 1746.Correlation Coefficient Generation on a Commercially Available Real-Time fMRI Scanner with Rapid Fusion of Anatomic Data for Application to Image-Guided Surgery Theodore Roosevelt Steger III1, Edward Jackson1 1University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. 1747.Can Improved Statistical Modeling Reduce Residual Autocorrelation in fMRI? Mehrdad Razavi1, Thomas J. Grabowski1, Sonya Mehta1, Lizann Bolinger1 1The University of Iowa, Iowa City, IA, USA. 1748.Regression of a Semi Parametric Model of fMRI Time-Series in the Wavelet Domain Francois G Meyer1, Gregory McCarthy2 1University of Colorado, Boulder, CO, USA; 2Duke University, Durham, NC, USA. 1749.Using a Spectral Peak Statistic to Detect Potential fMRI Activiations Mark Jarmasz1, Rajmund Somorjai1 1National Research Council Canada, Winnipeg, MB, Canada. 1750.High fMRI Percent Enhancements at High Resolution J. S. Hyde1, B. B. Biswal1, A. Jesmanowicz1 1Medical College of Wisconsin, Milwaukee, WI, USA. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) MRI Safety and Bioeffects Forth Wednesday: 13:30 - 15:30 Chairs: Geoffrey D. Clarke David G. Norris Roger J. Ordidge 13:30 1751.Vibroacoustic Modeling of Noise in Magnetic Resonance Imagers Robert A. Hedeen1, Richard P. Mallozzi1, William A. Edelstein1, Timothy J. Havens2 1GE Corporate R & D, Schenectady, NY, USA; 2GE Medical Systems, Florence, SC, USA. 13:40 1752.Acoustic Noise Reduction in a 4T Whole Body MR Imager Chris K. Mechefske1, Yuhua Wu1, Brian K. Rutt2 1University of Western Ontario, London, Ontario, Canada; 2The John P. Robarts Research Institute, London, Ontario, Canada. 13:50 1753.Reduction of Acoustic Noise in Gradient Coils Peter Mansfield1, B. Haywood2, Ron Coxon1 1University of Nottingham, Nottingham, England, UK; 2General Magnetic. 14:00 1754.Stimulation of Peripheral Nerves by Fast Magnetic Field Gradients: A General Stimulation Forecast (GSF) Alexander Hoffmann1, Sonja C Faber, Maximilian Reiser 1University of Munich, Klinikum Grosshadern, München, Germany. 14:10 1755.Stimulation Study of a Field Flexible Gradient System Martin Brand1, Johann Schuster2, Ralph Michael Kimmlingen1, Axel Haase1 1Universität Würzburg, Würzburg, Germany; 2Siemens AG, Erlangen, Germany. 14:20 1756.Estimating In Vivo Temperature Changes Due to Localized RF Heating from Interventional Devices Christopher J. Yeung1, Ergin Atalar1 1Johns Hopkins University, Baltimore, MD, USA. 14:30 1757.Heating Effects around Resonant Lengths of Wire during RF Excitation Jacqueline Pictet1, Stephan Wicky2, Reto Meuli2, Jacques J. van der Klink1 1EPFL, Lausanne, Switzerland; 2CHUV Lausanne, Lausanne, Switzerland. 14:40 1758.Classical Analysis of RF Power Requirements in MRI Tamer Ibrahim1, Robert Lee1, Brian Baertlein1, Pierre-Marie L. Robitaille1 1Ohio State University, Columbus, OH, USA. 14:50 1759.Heat Distribution Near Pacemaker Lead Tips Roger Luechinger1, Oliver M. Weber1, Marcel Bieler1, Peter Boesiger1 1University and ETH Zurich, Zurich, Switzerland. 15:00 1760.Magnet Radius, Field Strength and the "Moses Effect" Daniel Schaefer1 1G. E. Medical Systems, Milwaukee, WI, USA. 15:10 1761.Influence of Static Magnetic Fields and Magnetic Gradient Fields on Tumor Cell Cycle Elke Maria Teichmann1, Jan Hengstler1, Ilka Schiffer1, Wolfgang Schreiber1, Robert Graf2, Franz Oesch1, Hans Wolfgang Spiess2, Manfred Thelen1 1Johannes Gutenberg-University, Mainz, Germany; 2Max-Planck-Institute of Polymer Research, Mainz, Germany; 15:20 1762.MRI at 3.0 Tesla: Preliminary Ex Vivo Animal and In Vivo Human Safety Studies. A. Gregory Sorensen1, Ona Wu2, Kei Yamada3, J. Thomas Vaughan4 1Massachusetts General Hospital, Charlestown, MA, USA; 2MGH-NMR Center and MIT, Cambridge, MA, USA; 3MGH-NMR Center, now at Kyoto Prefectural University of Medicine, Kyoto, Japan; 4MGH-NMR Center, now at University of Minnesota, Minneapolis, MN, USA. Safety and Bioeffects Hall 4 Thursday: 13:30 - 15:30 1763.Acoustic Noise on 1.5 T MRI Systems: Worst Case and Comparative Measurements David L. Price1, Janet P. De Wilde1, Annie M. Papadaki1, Jane S. Curran1, Richard I. Kitney1 1MagNET, Imperial College, London, UK. 1764.Stimulation Prediction by E-Field Simulation Martin Brand1, Oliver Heid2, Axel Haase1 1Universität Würzburg, Würzburg, Germany; 2Siemens AG, Erlangen, Germany. 1765.Stimulation Properties of Gradient Coils Martin Brand1, Oliver Heid2, Axel Haase1 1Universität Würzburg, Würzburg, Germany; 2Siemens AG, Erlangen, Germany. 1766.Sampling and Evaluation of Specific Absorption Rates during Patient Examinations Performed on 1.5-Tesla MR Systems Gunnar Brix1, Martin Reinl1, Gerhard Brinker2 1Federal Office for Radiation Protection, Oberschleissheim, Germany; 2Siemens AG, Erlangen, Germany. 1767.Intravascular MRI-Receiver Coils in Combination with Traps: Reducing Troubling Thermal Effects. Volker Matschl1, Johannes Heverhagen2, Heinz Julius Jaensch1, Marc Kalinowski1, Heiko Alfke1, Hans-Joachim Wagner1, Klaus Jochen Klose1 1Philipps University, Marburg, Germany; 2University Hospital Marburg, Marburg, Germany. 1768.Estimation of Resistive Pressure Effects in Mechanical Heart Valves due to MRI Neil Robertson1, Manuel Diaz-Gomez1, Barrie Condon1 1Institute of Neurological Sciences, Glasgow, Scotland, UK. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Rapid Imaging Clyde Auditorium Thursday: 13:30 - 15:30 Chairs: Stephen J. Riederer John P. Mugler Jürgen Hennig 13:30 1769.Hyperechoes in RARE(TSE, FSE)-Sequences Jürgen Hennig1, Klaus Scheffler1 1University Hospital Freiburg, Freiburg, Germany. 13:40 1770.Combining UNFOLD with SMASH or SENSE Bruno Madore1 1Harvard University, Boston, MA, USA. 13:50 1771.SENSE Image Quality Improvement Using Matrix Regularization Kevin King1 1G. E. Medical Systems, Milwaukee, WI, USA. 14:00 1772.Real-Time Partial Parallel Spiral Imaging with Localized Sensitivities Holger Eggers1, Peter Boernert1, Peter Boesiger2 1Philips Research, Hamburg, Germany; 2Swiss Federal Institute of Technology Zurich and University of Zurich, Zurich, Switzerland. 14:10 1773.Reducing Transverse Coherencies for Spoiled Gradient Echo Imaging Reed F. Busse1, Stephen J. Riederer1 1Mayo Clinic, Rochester, MN, USA. 14:20 1774.Fast Volume Coverage using Sliding, Nonuniform Angular Sampling: The Spiral CT Approach with Projection FLASH and TrueFISP Sequences Klaus Scheffler1 1Universität Freiburg, Freiburg, Germany. 14:30 1775.Optimization of Steady-State Pulse Sequences for Fast Phase Difference and Complex Difference Flow Imaging Vinay M. Pai1, Han Wen1 1National Institutes of Health, Bethesda, MD, USA. 14:40 1776.Dynamic Imaging of Time-Varying Objects Qi Zhao1, Nitin Aggarwal1, Yoram Bresler1 1University of Illinois at Urbana Champaign, Urbana, IL, USA. 14:50 1777.Fast 3D Imaging Using Variable-Density Spiral Trajectories Jin Hyung Lee1, Brian Hargreaves1, Dwight G. Nishimura1 1Stanford University, Stanford, CA, USA. 15:00 1778.Spiral Imaging on a Human Ultra-High-Field Scanner Josef Pfeuffer1, Shantanu Sarkar1, Pierre-Francois Van De Moortele1, Kamil Ugurbil1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 15:10 1779.Sub-Second Continuous 2D Non-Fourier Dynamic Adaptive MRI Using Near-Optimal Spatial Encoding Dimitrios Mitsouras1, Alan S. Edelman1, Lawrence Patrick Panych2, Ferenc A. Jolesz2, Gary Zientara2 1Massachusetts Institute of Technology, Cambridge, MA, USA; 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 15:20 1780.Fluid-Attenuated SSFP Imaging Neal K. Bangerter1, Shreyas Vasanawala1, Dwight G. Nishimura1 1Stanford University, Stanford, CA, USA. Fast Imaging: Sequence Variations Hall 4 Wednesday: 13:30 - 15:30 1781.Half-Fourier Single-Shot STEAM Imaging Jürgen Finsterbusch1, Jens Frahm1 1Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany. 1782.STEN Pulse Sequence: Application to Ultrafast Imaging. Pavel Shkarin1, Douglas L Rothman1 1Yale School of Medicine, New Haven, CT, USA. 1783.A Fully Refocused Gradient Recalled Echo (FRGRE) Pulse Sequence, with Specific Implementation and Optimization for Cardiac MRI Michael H. Buonocore1, Laurie B. Hildebrand2 1University of California, Davis, Sacramento, CA, USA; 2University of California, Davis, Davis, CA, USA. 1784.Steady-State Preparation for Spoiled Gradient Echo Imaging Reed F. Busse1, Stephen J. Riederer1 1Mayo Clinic, Rochester, MN, USA. 1785.Catalyzing the Steady State Using a Genetic Algorithm William Overall1, Dwight G. Nishimura1, B. S. Hu1 1Stanford University, Stanford, CA, USA. 1786.Reducing Signal Oscillations During the Approach to Steady State in True FISP Using Partial Dephasing Frederick H. Epstein1, Daniel Kim1, Elliot McVeigh2 1University of Virginia, Charlottesville, VA, USA; 2National Institutes of Health, Bethesda, MD, USA. 1787.Design and Application of a Robust Spectral-Spatial RF Pulse Neville Gai1, Kevin King2, Manojkumar Saranathan3, Yuval Zur4 1G. E. Medical Systems, Milwaukee, WI, USA; 2Biltmore Advanced Imaging Center, Phoenix, AZ, USA; 3Rockville, MD, USA; 4Tirat Carmel, Israel. 1788.Spin Echoes with a Quadratic Phase Modulation of the RF Pulse Train Patrick Le Roux1 1General Electric Medical Systems, Buc, France. 1789.Compressed Fast Spin Echo Kwan-Jin Jung1 1Brain Science Research Center, Taejon, South Korea. 1790.Reducing SAR in Real-Time SSFSE Imaging with Variable-Flip Hard Refocusing RF Pulses Reed F. Busse1, Stephen J. Riederer1 1Mayo Clinic, Rochester, MN, USA. 1791.Analysis of Single Echo, TR Periodic SSFP Sequences Yiu-Cho Chung1 1Siemens Medical Systems, Chicago, IL, USA. 1792.3D Burst Microscopic Imaging Sequence Yo Taniguchi1, Hisaaki Ochi1, K. Okajima1 1Hitachi, Ltd., Central Research Laboratory, Tokyo, Japan. Fast Imaging: Parallel Imaging Methods Hall 4 Wednesday: 13:30 - 15:30 1793.SMASH With Arbitrary Coil Array Geometries and Phase Encoding Directions Mark D. Price1, Charles A. McKenzie1, Ernest N. Yeh1, Michael A. Ohliger1, Jianmin Wang2, Daniel K. Sodickson1 1Beth Israel Deaconess Medical Center, Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA; 2Siemens AG, Erlangen, Germany. 1794.Simulation Based Analysis of the Effects of Imaging Depth on Partially Parallel Imaging Techniques James A. Bankson1, Steven M. Wright1 1Texas A&M University, College Station, TX, USA. 1795.Generalized Partially Parallel Imaging with Spatial Filters James A. Bankson1, Steven M. Wright1 1Texas A&M University, College Station, TX, USA. 1796.A SMASH Approach to Non-Integral Accelerations and Physical Regridding of Data Using Fractional Spatial Harmonics Ernest N. Yeh1, Charles A. McKenzie1, Michael A. Ohliger1, Mark D. Price1, Daniel K. Sodickson1 1Beth Israel Deaconess Medical Center, Harvard-MIT Division of Health Sciences Technology, Harvard Medical School, Boston, MA, USA. 1797.Imaging with an Array of RF Coils — a Space-Frequency Approach Yudong Zhu1 1GE Corporate R&D Center, Niskayuna, NY, USA. 1798.Increasing the SNR in Steady-State Imaging by Sensitivity Encoding Markus Weiger1, Klaas P. Pruessmann1, Paul R. Hilfiker2, Dominik Weishaupt2, Peter Boesiger1 1University and ETH Zurich, Zurich, Switzerland; 2University Hospital Zurich, Zurich, Switzerland. 1799.The Power Spread Function Effect on Low Resolution Sensitivity Encoded Imaging Xiaoli Zhao1, Zhu Li1, Robert Prost2, Shi-Jiang Li1 1Medical College of Wisconsin, Milwaukee, WI, USA; 2Froedtert Memorial Hosptial, Milwaukee, WI, USA. 1800.Fast Image Reconstruction for Sensitivity Encoded Spiral Imaging Stephan Kannengiesser1, John M. Pauly2, Rosemary Kim Butts2 1Aachen University of Technology, Aachen, Germany; 2Stanford University, Stanford, CA, USA. 1801.SENSE Geometry Factor Image Processing Amol Karnick1, Kevin King1 1G. E. Medical Systems, Milwaukee, WI, USA. 1802.Sensitivity Encoding (SENSE): Advantages and Disadvantages Yasuyuki Kurihara1, Yoshiko K. Yakushiji, Ichiro Tani, Yasuo Nakajima, Marc Van Cauteren 1St. Marianna University, Kawasaki City, Japan. Fast Imaging: Acquisition Strategies Hall 4 Wednesday: 13:30 - 15:30 1803.Dynamic Imaging Using k-space Sharing and Sliding Window Reconstruction James d'Arcy1, David Collins1, Ian Rowland1, Martin Leach1 1Institute of Cancer Research, Sutton, Surrey, UK. 1804.Teardrop, A Novel Non-Raster Readout for True FISP Christopher Kumar Anand1, Michael Thompson1, Dee H. Wu1, Tom Cull1 1Marconi Medical Systems, Cleveland, OH, USA. 1805.Shared k-Space Echo Planar Imaging with Keyhole Maxim Zaitsev1, Karl Zilles1, N. Jon Shah1 1Institute of Medicine, Research Centre Jülich, Jülich, Germany. 1806.Single TRajectory Radial (STAR) Imaging Gordon E. Sarty1 1University of Saskatchewan, Saskatoon, Saskatchewan, Canada. 1807.Echo Planar Pulse Sequence for 3D Dynamic Adaptive MRI Dimitrios Mitsouras1, Alan S. Edelman1, Lawrence P. Panych2, Ferenc A. Jolesz2, Gary P. Zientara2 1Massachusetts Institute of Technology, Cambridge, MA, USA; 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 1808.Fast Multiple-Excitation Multiple-Echo Spin-Echo Pulse Sequence for Non-Fourier Spatial Encoding Dimitrios Mitsouras1, Alan S. Edelman1, Lawrence Patrick Panych2, Ferenc A. Jolesz2, Gary Zientara2 1Massachusetts Institute of Technology, Cambridge, MA, USA; 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 1809.Increasing Acquisition Speed in Undersampled 3D Projection Imaging Yuriy Toropov1, Walter Block1 1University of Wisconsin-Madison, Madison, WI, USA. 1810.A Novel Subencoding Reconstruction Technique in 3D Half-Fourier FSE for Non-Contrast MRA without Flow-Related N/2 Artifacts Yoshio Machida1, Shigehide Kuhara1, Miguel Angel Gonzalez Ballester1, Hiroshi Takai1, Yoshimori Kassai1, Yoshinori Hamamura1 1Medical Systems R&D Center, Toshiba, Otawara, Tochigi, Japan. 1811.Single-Shot Imaging at Sub-Millimeter Resolution Using Adiabatic Outer-Volume-Suppression Josef Pfeuffer1, Pierre-Francois Van De Moortele1, Essa Yacoub1, Gregor Adriany1, Amir Shmuel1, Peter Andersen1, Hellmut Merkle1, Kamil Ugurbil1, Xiaoping Hu1 1University of Minnesota, Minneapolis, MN, USA. 1812.3D UNFOLD Technique for Dynamic MRI Yijing Wu1, Dennis L. Parker1, Andrew L. Alexander1 1University of Utah, Salt Lake City, UT, USA. General Clinical Cardiac Imaging Hall 4 Monday: 14:00 - 16:00 1813.Arrythmogenic Right Ventricular Dysplasia/Cardiomyopathy: Protocol Optimization of Black- and Bright-Blood Techniques - Part II Ernesto Castillo1, Julie Rutberg1, H. J.V. Braga1, H. G. Caulkins1, David A. Bluemke1 1Johns Hopkins University School of Medicine, Baltimore, MD, USA. 1814.Use of a Multi-Echo Gradient Echo Sequence for the Calculation of T2* Values in the Myocardium for the Analysis and Quantification of Iron Overload in Thalassemia Patients Clare Charrier1, Peter Gatehouse1, L. Anderson2, David N. Firmin3 1Royal Brompton Hospital, London, England, UK; 2Royal Brompton Hospital & Imperial College, London, UK; 3Imperial College of Science, Technology and Medicine, University of London, Royal Brompton Hospital, London, UK. 1815.Discordance Between LV Mass by Magnetic Resonance Imaging and Clinically-Used Partition Values for Discriminating Normal from Hypertrophic Left Ventricles Michael Chuang1, Carol J. Salton1, Susan Yeon1, Kraig Kissinger1, Peter Danias1, Warren J. Manning1 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 1816.The Quantification of Pulmonary Valve Haemodynamics Using MRI Scott Reid1, Peter Walker1, John Fisher1, Zsolt Nagy2, John Ridgway3, Kevin G Watterson2, Mohan Sivananthan3 1University of Leeds, Leeds, England, UK; 2Yorhshire Heart Centre, Leeds, UK; 3Leeds General Infirmary, Leeds, England, UK, 1817.Utility of MRI in the Evaluation of the Ascending Aorta in Patients with Surgical Aortic Valve Disease Vicente Sanjuan1, Jose Lopez Mut, Joaquin Rueda, Fernando Mas, Pilar Lopez, Jc Martinez, Vicente Miranda, Julian Celma, Ja Montero 1Hospital General Valencia, Valencia, Spain. 1818.Diagnosis and Follow-up of Surgical Repair on Ventricular Vicente M Sanjuan1, Joaquin Rueda, Sergio Canovas, Fernando Mas, Pilar Lopez, Jose Lopez Mut, Ja Montero, Julian Celma, Jose Velasco 1Hospital General Valencia, Valencia, Spain. 1819.Right Ventricular Involvement in Patients with Inferior Myocardial Infarction -Correlation of Contrast-enhanced Magnetic Resonance Imaging to Other Findings Matthias Gero Friedrich1, Jeanette Schulz-Menger1, Anja Wagner1, Rainer Dietz1 1Franz-Volhard-Klinik, Charite, Berlin, Germany. 1820.A Comparison between Magnetic Resonance Imaging and Echocardiography in the Evaluation of Pulmonary Hypertension John Foster1, Tarek Saba1, Muriel Cockburn1, Michael Cowan1, Andrew Peacock1 1Western Infirmary, Glasgow, UK. 1821.Right Ventricular Outflow Tract Tachycardia: MRI Findings Nefise Cagla Tarhan1, Ahmet Muhtesem Agildere1, Bulent Ozin1, Ali Firat1, Aydin Kurt1 1Baskent University Faculty of Medicine, Ankara, Turkey. 1822.MRI Guided Endomyocardial Biopsy in Patients with Suspected Myocarditis Guenther Schneider1, Roland Seidel1, Ingrid Janzen1, Bernhard Schwab1, Katrin Altmeyer1, Bernhard Kramann1 1University Hospital, Homburg/Saar, Germany. 1823.Regional Wall Motion Abnormality in Brugada Syndrome Using Stripe-Tagged MRI Makoto Motooka1, Naoaki Yamada1, Hidehiro Iida1, Shinichi Urayama1, Tetsuya Matsuda2, Makoto Takamiya1 1National Cardiovascular Center, Suita City, Osaka Japan; 2Kyoto University, Sakyo-ku, Kyoto, Japan. 1824.3D Reconstruction of Intra-cardiac Anatomy: A Comparison of Magnetic Resonance Imaging (MRI), Intra-cardiac Echocardiography (ICE) and Trans-esophagal Echocardiography (TEE). M E Miquel1, R S Razavi2, E J Baker2, S F Keevil1 1Thomas Guy House, London, UK; 2Guy's Hospital, London, UK. 1825.Assessment of Right Atrium and Ventricle of Mulibrey Nanism Patients with Functional Magnetic Resonance Imaging Sari Marjut Kokki1, Kirsi Lauerma1, Markku Kupari1, Pauli Hekali1, Marita Lipsanen-Nyman1 1Helsinki University Hospital, Helsinki, Finland. High-Field Cardiac Imaging Hall 4 Monday: 14:00 - 16:00 1826.Cardiac Triggering at 3.0 Tesla Stefan E. Fischer1, Jan den Boef1, Filip Vugts1 1Philips Medical Systems, Best, The Netherlands. 1827.Signal-to-Noise Ratios in Human Cardiac Imaging: Comparison of 3 T and 1.5 T Ralph Noeske1, Frank Seifert1, Karl-Heinz Rhein1, Axel Bornstedt2, Bernhard Schnackenburg3, Herbert Rinneberg1 1Physikalisch-Technische Bundesanstalt, Berlin, Germany; 2German Heart Center Berlin, Berlin, Germany; 3Philips Medical Systems, Hamburg, Germany. 1828.Human Cardiac MRI at 3 Tesla Using a Whole Body Radio Frequency Coil Robert L. Greenman1, Robert E Lenkinski1, David Alsop1, Ronald Watkins2, John F Schenck2, Randy Giaquinto2, Joseph Piel2, Kenneth Rohling2 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 2General Electric Corporate Research and Development Center, Schenectady, NY, USA. 1829.In Vivo Measurement of Myocardial Sodium T2* Wolfgang Schreiber1, Simone Laukemper-Ostendorf1, Melanie Schmitt1, Karl Friedrich Kreitner1, Oliver Klaus Mohrs1, Manfred Thelen1 1Johannes Gutenberg-University, Mainz, Germany. 1830.Oxygenation Dependence of T2* and T1 in the Isolated Rate Heart at 11.75T Sascha Kohler1, Karl-Heinz Hiller1, C. Heindl1, W. R. Bauer1, Axel Haase1 1University Wurzburg, Wurzburg, Germany. 1831.Faster Left Ventricular Relaxation in Mouse Hearts Missing Muscle and Mitochondrial Creatine Kinase Tom C.-C. Hu1, Guy A. Macgowan2, Cong-Wu Du1, Alan Koretsky3 1Carnegie Mellon University, Pittsburgh, PA, USA; 2University of Pittsburgh Medical School, Pittsburgh, PA, USA; 3National Institutes of Health, Bethesda, MD, USA. 1832.Intracellular Sodium Imaging in Acute Coronary Ligation Jan G. Van Emous1, Marcel G.J. Nederhoff1, Cees J.A. Van Echteld1 1ICIN and University Medical Center, Utrecht, The Netherlands. 1833.MR Imaging at 7 Teslas of Myocardial Infarction in Rats : Assessment of Superparamagnetic Iron Oxide Nanoparticles Contrast Agent Catherine Chapon1, Florence Franconi1, Laurent Marescaux2, Laurent Lemaire3, Jean-Jacques Le Jeune4 1Université d'Angers, Angers, France; 2Ecole Nationale Vétérinaire, Nantes, France; 3Faculté de Médecine, Angers, France; 4C. H. U. Angers, Angers, France. Technical Advances in Cardiac Imaging Hall 4 Monday: 14:00 - 16:00 1834.Synchronising Cardiac and Respiratory Motion with an External Cuirass Respirator - A Novel Way of Improving Scanning Efficiency in Cardiac Magnetic Resonance Imaging Sven Plein1, Timothy N. Bloomer1, John P. Ridgway1, Gavin J. Bainbridge1, Zamir Hayek2, Mohan U. Sivananthan1 1Leeds General Infirmary, Leeds, West Yorkshire, UK; 2Medivent Ltd., London, UK. 1835.True FISP: Assessment of Accuracy for Measurement of Left Ventricular Mass in an Animal Model Wyatt C Jaffe1, David Fieno1, Orlando Simonetti2, Paul Finn1 1Northwestern University, Chicago, IL, USA; 2Siemens Medical Systems, Chicago, IL, USA. 1836.Cardiac Cine MR Imaging: Comparison between TrueFISP and FLASH Wei Li1, Qun Chen1, Robert R Edelman1, Pottumarthi V Prasad1 1Evanston Northwestern Healthcare, Northwestern University Medical School, Evanston, IL, USA. 1837.Comparison of Two Types of Fat-suppressed Black-blood MR Imaging for Fat, Myocardial and Flow Signals Suppresion and Cardiac Structure Visualization: Black-Blood Fast STIR and Black-blood CHESS MR Imaging Yasuo Amano1, Katsuya Takahama1, Tatsuo Kumazaki1, Hiroyuki Kabasawa1 1Nippon Medical School, Tokyo, Japan. 1838.Automatic Detection of Vortical Flow Patterns from Three-dimensional Phase Contrast MRI Einar Brandt1, Tino Ebbers1, Lars Wigström1, Jan Engvall1, Matts Karlsson1 1Linköping University, Linköping, Sweden. 1839.Parameters Affecting the MR Measurement of Pressure with Microbubbles Rohan Dharmakumar1, Donald Plewes1, Graham Wright1 1University of Toronto, Toronto, ON, Canada. 1840.Optimizing Magnetization Dynamics for Cardiac Microscopy Anja C.S. Brau1, Gary P. Cofer1, Laurence W. Hedlund1, G. Allan Johnson1 1Duke University Medical Center, Durham, NC, USA. 1841.Segmented 2D Imaging of the Heart with a Novel Motion Resistant Phase Ordering Technique Permi Jhooti1, Jennifer Keegan2, Peter Gatehouse3, David N. Firmin4 1London, England, UK; 2Royal Brompton Heart & Lung Hospital, London, England, UK; 3Royal Brompton Hospital, London, England, UK; 4Imperial College of Science, Technology and Medicine, University of London, Royal Brompton Hospital, London, UK. 1842.Combined Analysis of Ventricular and Atrial Motion using MRI Jerome M. Declerck1, Cengizhan Ozturk2, Luis Gutiérrez3, Guy Shechter3, Elliot R. McVeigh3 1Oxford University, Oxford, England, UK; 2Bogazici University, Istanbul, Turkey; 3National Institutes of Health, Bethesda, MD, USA. Coronary Artery Imaging Hall 4 Monday: 14:00 - 16:00 1843.Patient Monitoring during Coronary MRA by Real-time Spiral Imaging Peter Koken1, Holger Eggers1, Tobias Schäffter1, Dirk Manke2, Kay Nehrke1, Peter Börnert1 1Philips Research Hamburg, Hamburg, Germany; 2University of Karlsruhe, Karlsruhe, Germany. 1844.Real-Time Interactive Imaging Enhanced High-Resolution Magnetic Resonance Coronary Angiogram Phillip Yang1, Craig Meyer1, Michael McConnell1, Masahiro Terashima1, Shuichiro Kaji1, Al Macovski1, John Pauly1, Dwight Nishimura1, Bob Hu1 1Stanford University, Stanford, CA, USA. 1845.Faster Free-Breathing 3D Coronary MR Angiography using Multi-Stack Spiral Imaging Peter Börnert1, Dirk Manke2, Kay Nehrke1 1Philips Research Hamburg, Hamburg, Germany; 2University of Karlsruhe, Karlsruhe, Germany. 1846.About the Fat Suppression in 3D Spiral Coronary MR Imaging Peter Börnert1, Matthias Stuber2, René Botnar2, Kraig Kissinger2, Peter Koken1, Elmar Spuentrup2, Warren J. Manning2 1Philips Research Hamburg, Hamburg, Germany; 2Beth Israel Deaconess Medical Center, Boston, MA, USA. 1847.About the Superiority of Spiral Imaging in 3D Coronary MR Angiography Peter Börnert1, Matthias Stuber2, René Botnar2, Kraig Kissinger2, Peter Koken1, Elmar Spuentrup2, Warren J. Manning2 1Philips Research Hamburg, Hamburg, Germany; 2Beth Israel Deaconess Medical Center, Boston, MA, USA. 1848.3D Coronary Vessel Wall Imaging with a Local Inversion Technique and Spiral Image Acquisition René M. Botnar1, Won Y. Kim2, Matthias Stuber1, Peter Börnert3, Elmar Spuentrup2, Kraig V. Kissinger2, Warren J. Manning2 1Beth Israel Deaconess Medical Center, Philips Medical Systems, Boston, MA, USA; 2Beth Israel Deaconess Medical Center, Boston, MA, USA; 3Philips Research Laboratories, Hamburg, Germany. 1849.Ultra-Fast Navigator Technology and Real-Time Motion Correction Improves Image Quality in Submillimeter Navigator-Gated Free-Breathing 3D Coronary MRA Elmar Spuentrup1, Matthias Stuber1, René Michael Botnar1, Kraig V Kissinger1, Warren J. Manning1 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 1850.An Improved Diminishing Variance Algorithm for Respiratory Compensation in Coronary Imaging Robert Schaffer1, Craig Meyer1, Todd Sachs1, John M. Pauly1, Bob Hu1, Dwight G. Nishimura1 1Stanford University, Stanford, CA, USA. 1851.Tracking Three-Dimensional Volume-Selective Coronary Artery Imaging Peter Gatehouse1, Guang-Zhong Yang1, Jennifer Keegan2, Raad Hashem Mohiaddin1, David N. Firmin3 1Royal Brompton Hospital, London, England, UK; 2Royal Brompton Heart & Lung Hospital, London, England, UK; 3Imperial College of Science, Technology and Medicine, University of London, Royal Brompton Hospital, London, England, UK. 1852.Study of Respiratory Motion in Coronary MRA Dirk Manke1, Kay Nehrke2, Peter Rösch2, Peter Börnert2, Olaf Dössel1 1University of Karlsruhe, Karlsruhe, Germany; 2Philips Research Hamburg, Hamburg, Germany. 1853.Suppression of Motion Artifacts Using an Acoustic Respiratory Feedback Monitor Kay Nehrke1, Dirk Manke2, Peter Börnert1 1Philips Research Laboratories, Hamburg, Germany; 2University of Karlsruhe, Karlsruhe, Germany. 1854.Improved Coronary MRA Using a New Blood Pool Contrast Agent (P-792) and Respiratory Navigator Gating Martijn S. Dirksen1, Hildo J. Lamb1, Patrik Kunz1, Philippe Robert2, Claire Corot2, Albert De Roos1 1Leiden University Medical Center, Leiden, The Netherlands; 2Guerbet, Aulnay Sous Bois, France. 1855.Multi-Slice Breathhold Spiral MR Coronary Angiography in Combination with an Intravascular Feruglose Contrast Agent (NC100150 Injection) Patrick R Knuesel1, Daniel Nanz1, Ursula Wolfensberger1, Gustav K Von Schulthess1, Borut Marincek1, Juerg Schwitter1 1University Hospital Zurich, Zurich, Switzerland. 1856.3D Magnetization-Prepared True-FISP: A New Technique for the MR Imaging of Coronary Arteries Vibhas Deshpande1, Steven Shea1, Gerhard Laub2, Orlando Simonetti2, Paul Finn1, Debiao Li1 1Northwestern University, Chicago, IL, USA; 2Siemens Medical Systems, Chicago, IL, USA. 1857.Measuring Nitroglycerin Tolerance in the Right Coronary Artery; Preliminary Results Sten Oyre1, Michael S. Hansen1, Karsten Muff Munk1, Sebastian Kozerke2, Keld Sorensen1, Jens Erik Nielsen-Kudsk1, Peter Boesiger2, Erik Morre Pedersen1 1Aarhus University Hospital, Aarhus N., Denmark; 2University of Zurich, Zürich, Switzerland. 1858.Noninvasive Detection of Coronary Artery Stenosis By Using High-Resolution Selective Three-dimensional Coronary MR Angiography Yoshiki Amou1 1Kurashiki Central Hospital, Kurashiki, Okayama, Japan. 1859.Detection of MR Flow Disturbance in Small Diameter Tubes and Coronary Arteries Pamela K. Woodard1, Jie Zheng1, Dana R. Abendschein1, Richard Kowalski1, Nasser Fatouree1, Nikolaos V. Tsekos1, Amir A. Amini1, Robert J. Gropler1 1Washington University, St. Louis, MO, USA. 1860.Coronary Angiography of the Perfused Mouse Heart - Method and Visualization Karl-Heinz Hiller1, Sascha Köhler1, Sabine Voll1, Matthias Nahrendorf1, Christiane Waller1, Wolfgang R. Bauer1, Axel Haase1 1Universität Würzburg, Wurzburg, Germany. 1861.Feasibility of Adaptive Resolution Coronary Artery Imaging Charles H. Cunningham, Graham A. Wright and Michael L. Wood1 1University of Toronto, Sunnybrook and Women's College Health Sciences Centre, North York, ON, Canada. Myocardial Function and Flow Hall 4 Tuesday: 13:30 - 15:30 1862.Quantification of Left-to-Right Shunt in Pediatric Patients Philipp Beerbaum1, Hermann Körperich1, Peter Barth1, Hermann Esdorn1, Jürgen Gieseke2, Hans Meyer1 1Heartcenter NRW, Nordrhein-Westfalen, Germany; 2Philips Medical Systems, Hamburg, Germany. 1863.Assessment of Coronary Sinus Flow and Flow Reserve with Phase Contrast MR Imaging in Healthy Volunteers and Patients with CAD: A Comparison with PET Juha Koskenvuo1, Jaakko Hartiala1, Juhani Knuuti1, Hajime Sakuma2, Jyri Toikka1, Markku Komu1, Markku Saraste1, Pekka Niemi1 1Turku University Hospital, Turku, Finland; 2Mie University Hospital, Mie, Japan. 1864.High Temporal Resolution Multi-Echo Phase Contrast MRI Richard B Thompson1, Elliot R McVeigh1 1National Institutes of Health, Bethesda, MD, USA. 1865.Comparison of Cartesian and Radial Balanced FFE for Interactive Real Time Cardiac Imaging Tobias Schaeffter1, Steffen Weiss1, Holger Eggers1, Peter Börnert1, Volker Rasche1 1Philips Research, Hamburg, Germany. 1866.Torsion Scales Inversely with the Size of the Heart Between Mouse and Man Aravindan Kolandaivelu1, Han Wen2 1Howard Hughes Medical Institute-NIH Research Scholar, Bethesda, MD, USA; 2National Institutes of Health, Bethesda, MD, USA. 1867.Measurement of Left Ventricular Velocities: MR-Phase Contrast Velocity Mapping Versus Doppler-Ultrasound in Healthy Volunteers B Schneider1, M Markl1, B Saurbier1, A Geibel1, V Gehrig1, A Volz1, J Hennig1, M Langer1 1University of Freiburg, Freiburg, Germany. 1868.Assessment of Changes in Myofiber Orientation with MR-Diffusion Tensor Imaging after Regional Cardiac Infarction. Liesbeth Geerts-Ossevoort1, Theo Arts1, Peter Bovendeerd1, Klaas Nicolay2 1Eindhoven University of Technology, Eindhoven, The Netherlands; 2University Utrecht, Utrecht, Netherlands. 1869.Correlation Between Electrical and Mechanical Activation in the Paced Canine Heart Owen Faris1, Frank Evans2, Cengizhan Ozturk1, Daniel Ennis1, Joni Taylor2, Elliot McVeigh2 1Johns Hopkins University, Baltimore, MD, USA; 2National Institutes of Health, Bethesda, MD, USA. 1870.Visualization of Myocardial Strain-Rate Tensors from Time-Resolved 3D Cine Phase Contrast MRI Pernilla Selskog1, Einar Brandt1, Lars Wigström1, Matts Karlsson1 1Linköping University, Linköping, Sweden. 1871.Left Ventricular Apical Strain Measurements in the Human Heart Anthony Aletras1, Han Wen1 1National Institutes of Health, Bethesda, MD, USA. 1872.Strain Patterns from a 4D B-Spline Model of Tagged MRI: Baseline and Post-MI Studies J. Huang1, Dana R. Abendschein1, V. Davila-Roman1, Amir A. Amini1 1Washington University, St. Louis, MO, USA. 1873.Imaging Longitudinal Cardiac Strain on Short-Axis Images using 3D-HARP Nael F Osman1, Smita Sampath1, Ergin Atalar1, Jerry Ladd Prince1 1Johns Hopkins University, Baltimore, MD, USA. 1874.Accuracy of 3D Myocardial Strains from a 4D B-Spline Deformable Model for Tagged MRI J. Huang1, Amir A. Amini1 1Washington University, St. Louis, MO, USA. 1875.Cardiac Motion Encoding using HARP and DENSE: Tagging or Phase Contrast? J. Andrew Derbyshire1, Nael F. Osman2 1GE Medical Systems, Waukesha, WI, USA; 2Johns Hopkins University, Baltimore, MD, USA. 1876.Limiting Dilatation Decreases Infarct Size in an Ovine Model of Acute Myocardial Infarction Aaron S. Blom1, James J. Pilla1, Daniel J. Brockman2, Lawrence Dougherty1, Joseph Giammarco1, Frank W. Bowen1, Qing Yuan1, Victor Ferrari1, Michael A. Acker1, Leon Axel1 1University of Pennsylvania Medical Center, Philadelphia, PA, USA; 2University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA. 1877.Partial Left Ventriculectomy Acutely Improves Cardiac Function as Assessed by Tissue-tagged MRI Aaron S. Blom1, James J. Pilla1, Daniel J. Brockman2, Victor A. Ferrari1, Matthew Beal2, Christopher Jobes1, Michael A. Acker1, Leon Axel1 1University of Pennsylvania Medical Center, Philadelphia, PA, USA.; 2University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA. 1878.Visualization of Left Ventricular Function under Physically Induced Stress by Interactive Real-Time MRI Oliver Weber1, Markus Oelhafen1, Holger Eggers2, Peter Börnert2, Peter Boesiger1 1University and ETH Zurich, Zurich, Switzerland; 2Philips Research, Hamburg, Germany. 1879.Cardiac Function Evaluation in a Single Breath-Hold: Real-Time True FISP Cine Imaging Vivian S. Lee1, Daniel Resnick1, Peter Lee2, Jeffrey Bundy3, Orlando Simonetti3, Gerhard Laub3, Glenn A. Krinsky1, Jeffrey C. Weinreb1 1New York University Medical Center, New York, NY, USA; 2Albert Einstein School of Medicine, Bronx, NY, USA; 3Siemens Medical Systems, Chicago, IL, USA. 1880.Ultra-High Resolution True FISP Projection Reconstruction Acquisition for Cardiac Function Evaluation Dana C. Peters1, Elliot R. McVeigh1 1National Institutes of Health, Bethesda, MD, USA. 1881.Real-Time Echo and Spiral Planar Imaging for the Assessment of Left Ventricular Function - A Comparison Oliver Weber1, Markus Oelhafen1, Holger Eggers2, Peter Börnert2, Peter Boesiger1 1University and ETH Zurich, Zurich, Switzerland; 2Philips Research, Hamburg, Germany. 1882.Multi-echo Projection Reconstruction for Real-time Cardiac MRI Dana C. Peters1, Richard B. Thompson1, Elliot R. McVeigh1 1National Institutes of Health, Bethesda, MD, USA. 1883.Rapid Evaluation of Right Ventricular Volume and Mass Without Breath-holding Using Real-Time Interactive Cardiac Magnetic Resonance Imaging System Shuichiro Kaji1, Phillip Yang2, Craig Meyer2, John M. Pauly2, Bob Hu2 1Kawasaki Medical School, Kurashiki, Okayama Japan; 2Stanford University, Stanford, CA, USA. 1884.Evaluation of Left Ventricular Volumes and Ejection Fraction with Fast Steady-state Cine MR Imaging: Comparison with Left Ventriculography Yasutaka Ichikawa1, Hajime Sakuma1, Kakuya Kitagawa1, Nanaka Kawada1, Kan Takeda1, Munenobu Motoyasu1, Atsushi Nozaki2 1Mie University School of Medicine, Tsu, Mie, Japan; 2GE Yokogawa Medical Systems, Hino, Tokyo, Japan. 1885.Assessment of Ventricular Function in a single Breath-hold using Real-time TrueFISP Cine Imaging Jörg Barkhausen1, Gerhard Laub2, Mathias Goyen1, Jorg F Debatin1, Stefan G Ruehm1, Mark E Ladd1 1University Hospital Essen, Essen, Germany; 2Siemens Medical Systems, Inc., Chicago, IL, USA. 1886.Direct Comparison of Fast Gradient Echo, Segmented EPI, and FISP Variants of High Resolution Cine MRI Andrew Ernest Arai1, Melissa Coleman1, Kwabena Agyeman1, Anthony Homer Aletras1 1National Institutes of Health, Bethesda, MD, USA. 1887.Left Ventricular Function Measurement and Visualization of Endocardium Using Noncontrast-Enhanced Cardiac Cine SSFP Imaging Frandics Chan1, Marcus Alley1, Curtis Coulam1, A. Shimakawa2, Kristin Wedding1, Norbert J. Pelc1, Robert J. Herfkens1 1Stanford University, Stanford, CA, USA; 2GE Medical Systems, Milwaukee, WI, USA. 1888.Single Breath-hold Ejection Fraction Determination by 3D Cine Imaging Mark B.M. Hofman1, Piotr A. Wielopolski2, Willem G. van Dockum1, Anja Lehning3, Mathijs Oudkerk4, Albert C. van Rossum1 1University Hospital Vrije Universiteit, Amsterdam, Netherlands; 2University Hospital Rotterdam, Rotterdam, Netherlands; 3Nycomed Amersham Comet, Ismaning, Germany; 4University Hospital Groningen, Groningen, Netherlands. 1889.Noninvasive Assessment of Ventricular Contractility During Cardiac MRI Examinations Randy Setser1, Jon Chia1, Kamilla Lunn1, Kay Sayre1, Sebastian Flacke1, Christine Lorenz1 1Washington University, Saint Louis, MO, USA. 1890.A Noninvasive MR imaging Strategy for Predicting Left Ventricular Remodeling Maythem Saeed1, Norbert Watzinger1, Gunar Lund1, Michael F Wendland1, Charles B Higgins1 1University of California San Francisco, San Francisco, CA, USA. 1891.Simultaneously Quantitative Analysis for Right Ventricular and Left Ventricular Functions with MRI in a Rat Pulmonary Hypertension Model Yi-Jen Lin-Wu1, Shinichi Kanno1, Chien Ho1 1Carnegie Mellon University, Pittsburgh, PA, USA. 1892.Oral Administration of Nicorandil Improves Left Ventricular Function: A Long-Term MR Study in Rats Maythem Saeed1, Norbert Watzinger1, Gunnar Lund1, Michael F Wendland1, Mitsuaki Chujo2 1University of California San Francisco, San Francisco, CA, USA; 2Chugai Pharmaceutical Co, Ltd, Cuo-Ku, Tokyo, Japan. 1893.Calculation of Left Heart Pressure Gradients with Breath-Hold Phase Contrast MRI Richard B Thompson1, Elliot R McVeigh1 1National Institutes of Health, Bethesda, MD, USA. 1894.Right Ventricular Dilatation as Determined by MRI Correlates Closely with Clinical Deterioration of Functional Class in Patients with Primary Pulmonary Hypertension Michael Poon1, Jeffrey Goldman1, Zahi Fayad1, Kevin Dunsky1, Ann Marie McDonald1, Valentine Fuster1 1Mount Sinai School of Medicine, New York, NY, USA. 1895.Cine Magnetic Resonance Imaging of Myocardial Ischemia and Reperfusion in Mice Stuart Scott Berr1, Zequan Yang1, Wesley D. Gilson1, John N. Oshinski2, Brent A. French1 1University of Virginia, Charlottesville, VA, USA; 2Emory University, Atlanta, GA, USA. Myocardial Perfusion and Viability Hall 4 Tuesday: 13:30 - 15:30 1896.Validation of MRI Myocardial Perfusion in Humans with PET Thomas Fritz-Hansen1, Jens Hove2, Klaus Kofoed2, Henning Kelbaek2, Henrik Larsson1 1Hvidovre University Hospital, Hvidovre, Denmark; 2Rigshospitalet, Copenhagen, Denmark. 1897.Serial First Pass Contrast Perfusion MRI Following Coronary Artery Angioplasty (PTCA) in Patients with Single Vessel Disease: Qualitative and Quantitative Image Analysis Penelope R. Sensky1, Nilesh J Samani1, Graham R. Cherryman2 1Glenfield Hospital, Leicester, Leics, UK; 2University of Leicester, Leicester, Leics, UK. 1898.Myocardial Perfusion Measurements with First-Pass MRI in Patients with Coronary Artery Disease: A Comparison Between Semi-Quantitative and Quantitative Evaluation Melanie Schmitt1, Oliver Klaus Mohrs1, Wolfgang Günther Schreiber1, Steffen Ehrhard Petersen1, Karl-Friedrich Kreitner1, Thomas Voigtländer1, Magalie Viallon1, Thomas Wittlinger1, Georg Horstick1, Steffen Ziegler1, Jürgen Meyer1, Manfred Thelen1 1Johannes Gutenberg-University, Mainz, Germany. 1899.A Non ECG-gated Model for Myocardial Perfusion Imaging; Evaluation of Diagnostic Performance Evaluation in Patients with Coronary Artery Disease (CAD) Penelope R. Sensky1, Mark Horsfield2, Nilesh J Samani1, Graham R. Cherryman3 1Glenfield Hospital, Leicester, Leics, UK; 2Leicester Royal Infirmary, Leicester, Leics, UK; 3University of Leicester, Leicester, Leics, UK. 1900.Influence of Dispersion on Quantification of Myocardial Perfusion and Perfusion Reserve with First-Pass MRI: Simulations Using MMID4 Melanie Schmitt1, Wolfgang Günther Schreiber1, Magalie Viallon1, Manfred Thelen1 1Johannes Gutenberg-University, Mainz, Germany. 1901.Correction of Flow Effects in Renal and Myocardial Tissue Perfusion Quantification using Dynamic MRI and Contrast Media Marko K. Ivancevic1, Ivan Zimine1, François Lazeyras1, David Foxall2, Jean-Paul Vallee1 1Geneva University Hospital, Geneva, Switzerland; 2Marconi Medical Systems, Cleveland, OH, USA; 1902.The Regional Blood Volume in Human Myocardium: Determination with MRI using NC100150 (CLARISCAN"!) Christian M Wacker1, Frank Wiesmann1, Michael Bock2, Peter Jakob1, Jörn Sandstede1, Volker Hoffmann3, Lothar Schad2, Wolfgang Bauer4 1University of Wuerzburg, Wuerzburg, Germany; 2German Cancer Research Center DKFZ, Heidelberg, Germany; 3Ismaning, Germany; 4Klinikum Mannheim, Mannheim, Germany. 1903.T1 Fast Acquisition Relaxation Mapping (T1 FARM): An Alternative Bolus Tracking Technique Deanna D. Bellamy1, Charles A. McKenzie2, Frank S. Prato1, Dick J. Drost1 1University of Western Ontario, St. Joseph's Health Centre, London, Ontario, Canada; 2Beth Israel Deaconess Medical Center, Boston, MA, USA. 1904.Automatic Quantitative Analysis of Myocardial Perfusion with Magnetic Resonance Imaging Marcel Breeuwer1, Marcel Quist1, Luuk Spreeuwers2, Ingo Paetsch3, Nidal Al-Saadi3, Eike Nagel3 1Philips Medical Systems QV 1, Best, The Netherlands; 2University Medical Center Utrecht, Utrecht, The Netherlands; 3German Heart Institute Berlin, Berlin, Germany. 1905.A Fast, Multiple-Slice, Multiple-Point Method for the Determination of T1 Relaxation Time for Use in Quantitative Myocardial Perfusion Measurement John P Ridgway1, Aleksandra Radjenovic1, David M Higgins1, Andrea Kassner2, Mohan Sivananthan1 1Leeds General Infirmary, Leeds, UK; 2Philips Medical Systems, Leeds, UK. 1906.Myocardial Perfusion Measurements With Albumin-Binding MS-325 Contrast Agent Michael Jerosch-Herold1, Robert M. Weisskoff2, Norbert Wilke1, Cory Swingen1, Abdul Mansoor1, Hong Huang1, Fan Zhao1 1University of Minnesota, Minneapolis, MN, USA; 2Epix Medical Inc., Boston, MA, USA. 1907.Use of Cardiac MRI in Evaluating Acute Infarct Size and Ventricular Remodeling in an Animal Model of Heart Failure Subsequent to Reperfused Myocardial Infarction John N Oshinski1, Jeffery R Jones2, Jamie F Mata2, Zequan Yang2, Brent A. French2 1Emory University, Atlanta, GA, USA; 2University of Virginia, Charlottesville, VA, USA. 1908.A Canine Model of Hibernating Myocardium using Magnetic Resonance Imaging with Gd-DTPA Katie S. Lekx1, Frank S. Prato1, Jane Sykes1, Gerald Wisenberg1 1University of Western Ontario, London, Ontario, Canada. 1909.Interventional MRI For Monitoring Changes in Morphology of Rat Heart Following Myocardial Infarction and Assessing Guided Percutaneous Therapy Yael Mardor1, Israel M Barbash1, Micha Feinberg1, Ariel Tessone1, Sharon Aboulafia-Etzion1, Arie Orenstein1, Jesus Ruiz-Cabello2, Jack S Cohen1, Jonathan Leor1 1Sheba Medical Center, Tel-Hashomer, Israel; 2Universidad Complutense, Madrid, Spain. 1910.MR Assessment of Left Ventricular Function: Comparison to PET Perfusion and Metabolism Studies. G.D. Waiter1, A. Al-Mohammad2, M. Egred2, S.I.K. Semple1, T.W. Redpath1 1University of Aberdeen, Aberdeen, UK; 2Grampian University Hospitals NHS Trust, Aberdeen, UK. 1911.Effects of Regional Flow and Energetics on Rb+ Uptake and Injury in Isolated Pig Hearts: 87Rb Imaging and 31P Spectroscopic MR Studies Valerie Kupriyanov1, Bo Xiang1, Jiankang Sun1, Olga Jilkina2, George Dai1, Roxanne Deslauriers1 1National Research Council, Winnipeg, MB, Canada; 2University of Manitoba, Winnipeg, MB, Canada. 1912.87Rb MRI of Rb+ Uptake in Pig Hearts Following Regional Ischemia: Effects of Drugs Affecting K+ Permeability Valerie Kupriyanov1, Bo Xiang1, Jiankang Sun1, Olga Jilkina2, Roxanne Deslauriers1 1National Research Council, Winnipeg, MB, Canada; 2University of Manitoba, Winnipeg, MB, Canada. Carotid MR Angiography Hall 4 Wednesday: 13:30 - 15:30 1913.Magnetization Prepared Time of Flight Angiography of the Carotid Arteries at Three Tesla Steven D. Thomas1, Derek J Emery1, Alan H. Wilman1 1University of Alberta, Edmonton, Alberta, Canada. 1914.High Resolution 3D Contrast Enhanced MRA: Applications Using a Mid- Field Open Magnet Yu Liu1, Robert Breger1, Tonya Hollrith1, Lynda Yanny1 1St. Luke's Medical Center, Milwaukee, WI, USA. 1915.High Resolution, Reproducible Assessment of Carotid Stenosis with MRA Using Gadolinium Blood Pool Agents William Guerin Bradley1, Dar-Yeong Chen1, Gordan Lai1, Monte Zarlingo1, Christopher Swanson1, George Chu1, Mark Chen1 1Long Beach Memorial MRI Center, Long Beach, CA, USA. 1916.Gadobenate Dimeglumine in Contrast Enhanced Magnetic Resonance Angiography of the Carotid Arteries Biagio Merlino1, Hans Rainer Hentrich2, Massimo Daprà3, Miles Andrew Kirchin4, Lorenzo Bonomo1 1University of Chieti, Chieti, Italy; 2Bracco Byk Gulden, Konstanz, Germany; 3Bracco SpA, Milan, Italy; 4Medical & Regulatory Affairs, Milan, Italy. 1917.Optimal Contrast-Dose of an Intra-Vascular Contrast Agent in High-Resolution, Time-Resolved CE 3D-MRA of the Carotid Arteries in a Swine Model Thomas Hany1, Timothy Carroll1, Jiang Du2, Yousef Mazaheri3, Charles A. Mistretta1, Thomas Grist1 1University of Wisconsin-Madison, Madison, WI, USA; 2University of Wisconsin-Madison, Veterans Administration Hospital, Madison, WI, USA; 3Medical College of Wisconsin, Milwaukee, WI, USA. 1918.The Carotid Bifurcation As A Blood Flow Pulsatility Low-Pass Filter Characterized by Magnetic Resonance Phase Contrast Flow Quantitation Methods Calvin Hisley1, Moriel NessAiver1 1University of Maryland, Baltimore, Baltimore, MD, USA. 1919.Flow Insensitive Black-Blood Extracranial MRA by Using Double-IR and Dual-Contrast FSE Kecheng Liu1, Agus Priatna1 1Marconi Medical Systems, Cleveland, OH, USA. 1920.A Neurovascular Coil: Aortic Arch and Carotid Bifurcation Assessment with Combined Time Of Flight and Contrast Enhanced Angiography Nigel Hoggard1, Iain D Wilkinson1, Trevor J Cleveland2, Peter A Gaines2, Simon Thomas1, Graham S Venables2, Paul D Griffiths1 1University of Sheffield, Royal Hallamshire Hospital, Sheffield, England, UK; 2Sheffield Teaching Hospitals NHS Trust, Sheffield, England, UK. Peripheral MR Angiography Hall 4 Wednesday: 13:30 - 15:30 1921.Artery-Vein Separation of MRA Images with Blood Pool Contrast Agents Jan De Becker1, Raja Muthupillai2, Robert Stefancik3 1Philips Medical Systems, Best, Netherlands; 2Philips Medical Systems, St. Luke's Episcopal Hospital, Houston, TX, USA; 3EPIX Medical, Inc., Cambridge, MA, USA. 1922.Peripheral 3D MRA using SLINKY Acquisitions with Fat-Suppressed MTC pulse Satoru Kohno1, Susmu Moriya2, Akihiro Ishikawa1 1Shimadzu Corpopration, Kyoto Japan; 2Sakazaki Clinic, Japan. 1923.Nonenhanced Peripheral MR Aortography: Diastolic and Systolic ECG-triggered Moving-Bed Acquisition Mitsue Miyazaki1, Hiroshi Takai1, Hirofumi Wada2, Takashi Ogikawa2, Rie Kuwahara2, Joji Urata2 1Toshiba Corp. Medical R&D Center, Otawara, Tochigi Japan; 2Saiseikai Kumamoto Hospital, Kumamoto, Kumamoto, Japan. 1924.Gadobenate Dimeglumine in Contrast Enhanced Magnetic Resonance Angiography of the Pelvic Arteries Johan Wikström1, Håkan Ahlström1, Martin Wasser2, Peter Mt Pattynama3, Hans-Rainer Hentrich4, Massimo Daprà5, Miles Kirchin5, Alberto Spinazzi5 1Department of Radiology, Uppsala, Sweden; 2Department of Radiology, Leiden, The Netherlands; 3Department of Radiology, Rotterdam, The Netherlands; 4Bracco-Byk Gulden GmbH, Konstanz, Germany; 5BRACCO S.p.A., Milano, Italy. 1925.Table-Moving Fat Suppresed Gd-Enhanced MRA of the Abdominal Aorta and Lower Extremities using ProSet in Patients with Atherosclerotic Disease; Comparison with Conventional MRDSA Masayuki Kumashiro1 1Kurashiki Central Hospital, Okayama Japan. 1926.Bolus-Chase Gadolinium Enhanced MRA Improves Branch-Vessel Visualization in the Evaluation of Patients with Aortic Aneurysm and Dissection David Roberts1, P. Hansen1, J. Patel1, M. Farner1, D. Torigian1, R. Baum1, J. Carpenter1, R. Fairman1, Mitchell Schnall1 1University of Pennsylvania, Philadelphia, PA, USA. 1927.Bolus Chase 3D-MRA in Patients with Arterial Occlusive Disease of the Lower Extremities Treated with Metallic Stent Placement Yoko Saito1, Hiroshi Noda1, Hiraku Yodono1, Taisuke Sasaki1, Yoshinao Abe1, Toshiaki Tsuji1, Kouji Shirakawa1, Satoshi Naraki1 1Hirosaki University Hospital, Hirosaki, Aomori, Japan. 1928.High-Resolution Whole Body 3D MR Angiography (AngioSURF): A Dose-Finding Study Silke Bosk1, Stefan G Ruehm1, Uwe Fronz1, Thomas Lauenstein1, Jörg F Debatin1, Mathias Goyen1 1University Hospital Essen, Essen, Germany. 1929.Fat-Saturated versus Subtracted Multistation Contrast-Enhanced Peripheral MRA Tim Leiner1, Thomas T. de Weert1, Boudewijn Vasbinder1, Alphons G.H. Kessels1, Kai Yiu Ho1, Jos M.A. van Engelshoven1 1Maastricht University Hospital, Maastricht, The Netherlands. Abdominal and Thoracic MR Angiography Hall 4 Wednesday: 13:30 - 15:30 1930.Do Hyperventilation & Breath-holding Alter Contrast Dynamics for Contrast-Enhanced MRA? Giles Roditi1, Allan Reid1, Margot O'Hara1 1Glasgow Royal Infirmary, Glasgow, UK. 1931.Independent Contrast and Detail Scanning (ICDS): A New Method for Contrast Enhanced MR Angiography Dave Kaandorp1, Kai Yiu Ho1, Boudewijn Vasbinder1, Tim Leiner1, Jos Van Engelshoven1 1University Hospital Maastricht, Maastricht, Netherlands. 1932.Comparison of Spiral Flow Patterns in the Abdominal Aorta in Atheromatous Disease and Normal Subjects Using Phase Contrast Flow Quantitative MRI. John Graeme Houston1, Wendy Milne1, Jean-Paul Charon1, John Dick1, Peter Stonebridge1, Declan G. Sheppard1 1Tayside University Hospitals NHS Trust, Ninewells Hospital and Medical School, Dundee University, Dundee, Scotland, UK. 1933.Comparison of Contrast Enhanced MRA and DSA in the Assessment of Multiple and Accessory Renal Arteries. Jaroslaw Ryterski1, Jaroslaw Wieckowski2, Iwona Foremniak2, Andrzej Pytlewski1 1Institute of Psychiatry and Neurology, Warszawa, Poland; 2Wojewodzki Szpital Specjalistyczny, Radom, Poland. 1934.Assessment of Gadolinium-Enhanced Time-Resolved Three-Dimensional MR Angiography for Evaluating Renal Artery Stenosis Hatsuko Masunaga1, Yasuo Takehara1, Haruo Isoda1, Tatsuya Igarashi1, Masahiro Sugiyama1, Satoshi Isogai1, Nami Kodaira1, Hiroyasu Takeda1, Atsushi Nozaki2, Harumi Sakahara1 1Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; 2General Electric Yokogawa Medical Systems, Ltd., Hino, Tokyo, Japan. 1935.Gadolinum-Enhanced 3-D MR Angiography of Renal Artery Stenosis: A Pilot Comparison of Maximum Intensity Projection, Multi-Planar Reformatting, and 3-D Volume Rendering Post-Processing Algorithms Visveshwar Baskaran1, Frederick Scott Pereles1, Albert A Nemcek Jr.1, James Carr1, Frank H Miller1, John Ly1, Elizabeth A. Krupinski2, John Paul Finn1 1Northwestern University, Chicago, IL, USA; 2University of Arizona, Tucson, AZ, USA. 1936.2D fast Phase Contrast for Assessing Blood Flow in Renal Artery Stenosis Mirco Cosottini1, Virna Zampa1, Maria Chiara Michelassi1, Massimo Lombardi2, Davide Caramella1, Carlo Bartolozzi2 1University of Pisa, Pisa, Italy; 2Clinical Physiology Institute, Pisa, Italy. 1937.Quantitative Analysis of Renal Perfusion during Gd-Enhanced MRA in Healthy Kidney Donors: Age-Related Changes. Sjoerd van den Dool1, Martin Wasser1, Hans de Fijter1, Rob van der Geest1 1Leiden University Medical Center, Leiden, Netherlands. 1938.Contrast Enhanced Magnetic Resonance of the Renal Veins in the Setting of MRA of Potential Kidney Donors: Optimization of a Pulse Sequence Bert Van Heerebeek1, Shahid Hussain1, Maria G.M. Hunink1, Gabriel P Krestin1 1Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands. 1939.Evaluation of MR Angiography in the Assessment of Thoracic Outlet Syndrome. Jean-Pierre M Charon1, J Graham Houston1, Declan G Sheppard1, James S Anderson1 1Tayside Univerities Hospital Trust, Ninewells Hospital and Medical School, Dundee, Scotland. 1940.Gadolinium Enhanced 3D Magnetic Resonance Angiogrophy Planning of Stent Implantation in Aortic Coarctation and Recoarctation Reza Razavi1, Marc Eric Miquel2, Eric Rosenthal3, Shakeel Qureshi3, Edward James Baker4 1King's College London, Guy's King's and St Thomas' School of Medicine and Dentistry, Guy's Hospital, London, UK; 2King's College London, London, UK; 3Guy's Hospital, London, UK; 4King's College London, Guy's, King's and St Thomas' School of Medicine, London, UK. 1941.Fast Contrast-Enhanced 3D MRA of Congenital Cardiovascular Disease: Clinical Utility Velandai Sundararaman1, M.S. Ranjith1, K. Murali1, D.R. Subramaniam1, R. Sridhar1 1Sri Ramachandra Medical College, Chennai, India. 1942.Contrast Enhanced MRA in Detection of Pulmonary Arteriovenous Malformations Guenther Schneider1, Roland Seidel1, Katrin Altmeyer1, Urban Geisthoff1, Bernhard Kramann1 1University Hospital, Homburg/Saar, Germany. 1943.Morphologic and Functional Assessment of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) by Breath-hold MR Techniques: Findings Before and After Thromboendarterectomy Karl Friedrich Kreitner1, Sebastian Ley1, Peter Kalden1, Thorsten Kramm1, Eckardt Mayer1, Manfred Thelen1 1Johannes Gutenberg Universität, Mainz, Germany. 1944.Delineation of Venous Structure of the Upper Abdomen Using Gd-enhanced Time-Resolved 3D MR Angiography Satoshi Isogai1, Yasuo Takehara1, Haruo Isoda1, Hatsuko Masunaga1, Nami Kodaira1, Hiroyasu Takeda1, Harumi Sakahara1, Atsushi Nozaki2 1Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; 2GE Yokogawa Medical Systems, Hino, Tokyo, Japan. 1945.MR Venography of the Central Veins: Comparison of Direct Contrast-Enhanced 2D MR Fluoroscopic Venography with 3D MRV James Meaney1, John Ridgway1, Aleksandra Radjenovic1, Romhild Hoegeveen2, Jacqueline Roberts1, Daina Dambitis1, Marc Kouwenhoven1 1The General Infirmary at Leeds, Leeds, England, UK; 2Philips Medical Systems. 1946.Real-time MR Imaging for Assessment of Thrombosis in Pelvic Veins During Pregnancy Gabriele Anja Krombach1, Patrick Haage1, Tobias Schaefftler2, Volker Rasche2, A Rudlowski1, Arno Buecker1, Rolf W Guenther1 1University of Technology, Aachen, Germany; 2Philips Research Laboratories, Hamburg, Germany. 1947.Contrast Enhanced MRA in the Assessment of Congenital Heart Disease in Neonates and Infants. Andrew J Watt1, John Foster2, Abdu Shabani1 1The Royal Hospital for Sick Children, Glasgow, Scotland, UK; 2Western Infirmary, Glasgow, Scotland, UK. MR Angiography Techniques Hall 4 Wednesday: 13:30 - 15:30 1948.Time Resolved MRA with Elliptical Centric View Ordering Yong Zhou1, Timothy Carroll2, Emilio Esparza-Coss2, Thomas Grist2, Charles A. Mistretta2, Frank R. Korosec2 1G. E. Medical Systems, Milwaukee, WI, USA; 2University of Wisconsin-Madison, Madison, WI, USA. 1949.Evaluation of Model Fitting to a Time-Resolved SENSE Magnetic Resonance Angiography Measurement Frank Wajer1, Dirk Van Ormondt1, Miha Fuderer2, Johan Van Den Brink2, R. de Beer1 1Delft University of Technology, Delft, Netherlands; 2Philips Medical Systems, Best, Netherlands. 1950.MR Angiography using Steady State Free Precession Thomas K.F. Foo1, Vincent B. Ho2, Hani Marcos3, Maureen N. Hood2, Peter Choyke3 1GE Medical Systems, Johns Hopkins University, Baltimore, MD, USA; 2Uniformed Services University of the Health Sciences, Bethesda, MD, USA; 3National Institutes of Health, Bethesda, MD, USA. 1951.Optimization of Gadolinium Dose in 3D Contrast-Enhanced MRA with Elliptical Centric Acquisition -Analysis of Patient-Specific Flow Data and Approach to Small Dose MRA- Yuji Yuasa1, Hiroshi Shinmoto1, Akihiro Tanimoto1, Sachio Kuribayashi1, Atsushi Nozaki2 1Keio University School of Medicine, Tokyo, Japan; 2GE Yokogawa Medical Systems, Ltd., Tokyo, Japan. 1952.Gadobenate Dimeglumine (MultiHance®) in Contrast-Enhanced Thomas J. Kroencke1, Martin N. Wasser2, Peter M.T. Pattynama3, Hans-Rainer Hentrich4, Matthias Taupitz5, Bernd Hamm1, Miles Kirchin6, Alberto Spinazzi7 1Universitätsklinikum Charité, Berlin, Germany; 2Department of Radiology, Leiden, Netherlands; 3Academisch Ziekenhuis Rotterdam Dijkzigt, Rotterdam, The Netherlands; 4Bracco-Byk Gulden GmbH, Konstanz, Germany; 5Universitätsklinikum, Berlin, Germany; 6BRACCO S.p.A., Medical Affairs, Milan, Italy; 7Medical Affairs, Milano, Italy. 1953.Optimization of the Injection Protocol with P792, a New Blood Pool Contrast Agent, in the Conditions of Contrast-Enhanced MRA: Experimental Measurements in Rabbits and Pigs Philippe Robert1, Robin Santus, Xavier Violas, Marc Port1, Claire Corot1 1Guerbet, Roissy, France. 1954.Angio MR (AMR) of the Fingers: Technical Specificities and Clinical Applications Jean-Luc Drape1, Christophe Argaud2, Sophie Goettmann3, Didier Godefroy1, Anne-Marie Dupont1, Thierry Diche1, Alain Chevrot1 1Hopital Cochin, Paris, France; 2G. E. Medical Systems, Buc, France; 3Hôpital Bichat, Paris, France. 1955.A Comparison of Navigator Methods for the Minimization of Motion Artifacts in Pulmonary MR Angiography Richard Watts1, Thanh D. Nguyen1, Jeffrey W. Bezanson1, Martin R. Prince1, Yi Wang1 1Weill Medical College, Cornell University, New York, NY, USA. 1956.Dynamic ASL Flow Imaging with Cardiac Triggered True FISP Acquisition Qun Chen1, Vu M Mai1, Pippa Storey1, Robert R Edelman1 1Evanston Northwestern Healthcare, Evanston, IL, USA. 1957.MRI - A Tool for Evaluating the Feasibility of VEGF-Mediated Pro-Angiogenic Therapy Rinat Abramovitch1, Yuval Dor2, Ahuva Itin2, Eli Keshet2 1Hadassah Hebrew University Hospital, Jerusalem, Israel; 2Hebrew University, Hadassah Medical School, Jerusalem, Israel. 1958.Value of MRA Sequences and Contrast Agents For the Evaluation of High-Degree Stenosis: A Phantom Study. Bruno Marchand1, Philippe Douek2, Philippe Robert3, Claire Corot3, Jean Pierre Roux4, Patrice Adeleine5, Marcella Hernandez-Hoyos6, Maciej Orkisz6, Yannick Crémillieux6, Emmanuelle Canet4 1Hôpital de la Croix-Rousse, Lyon, France; 2Hôpital Cardiovasculaire, Lyon, France; 3Guerbet, Roissy, France; 4CREATIS, Hôpital Cardiologique, Lyon, France; 5Biostatistique et Informatique médicale, Lyon, France; 6CREATIS INSA 502, Villeurbanne, France. Vessel Wall MR Imaging Hall 4 Thursday: 13:30 - 15:30 1959.Quantitative MRI Study of Sustained VEGF Induced Blood-Retinal Barrier in Rabbits Nadir Alikacem1, Toyo Yoshizawa2, Kevin Nelson3, Charles Wilson1 1University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; 2Niigata University, School of Medicine, Niigata, Japan; 3University of Texas at Arlington, Arlington, TX, USA. 1960.Magnetization Transfer Maps of the Vulnerable Atherosclerotic Plaque Matthew M Philp1, Jerome L Ackerman2, Denise P Hinton2 1Boston University, Boston, MA, USA; 2Massachusetts General Hospital, Charlestown, MA, USA. 1961.Contrast Enhancement of Carotid Artery Outer Wall Boundary: Variability Study William Kerwin1, Thomas S. Hatsukami2, Chun Yuan1 1University of Washington, School of Medicine, Seattle, WA, USA; 2University of Washington, School of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. 1962.Assessment of Atherosclerotic Plaque Burden: Comparison of Vessel Wall Area Measurement Differences Among Three Black Blood Contrast Weighting MR Images Shaoxiong Zhang1, Thomas S. Hatsukami2, Chao Han1, Nayak Polissar3, Chun Yuan1 1University of Washington, School of Medicine, Seattle, WA, USA; 2University of Washington, School of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; 3University of Washington, School of Public Health and Community Medicine, Seattle, WA, USA. 1963.Efficient Black-Blood Carotid Artery Imaging Hee Kwon Song1, Alexander C. Wright1, Ronald L. Wolf1, Felix W. Wehrli1 1University of Pennsylvania Medical Center, Philadelphia, PA, USA. 1964.High Resolution Fast Spin Echo Black-Blood Imaging of Human Carotid Artery Wall at 4T Joseph Gati1, Jonathan Thomas1, David A. Steinman1, Brian K. Rutt1 1The John P. Robarts Research Institute, London, Ontario, Canada. 1965.Serial Evaluation of Luminal Narrowing in Apolipoprotein E-Deficient Mice Following Carotid Arterial Injury Using Magnetic Resonance Imaging Wesley D. Gilson1, David R Manka1, Ian J. Sarembock1, Klaus F. Ley1, John N. Oshinski1, Stuart Scott Berr1 1University of Virginia, Charlottesville, VA, USA. 1966.MRI Assessment of Carotid Atherosclerosis in an Asymptomatic Population: The Progression Study Chun Yuan1, Shaoxiong Zhang1, Jianming Cai2, Nayak Polissar3, Chao Han1, William Kerwin1, Carol Isaac4, Joe Davis4, Gerardo Ortiz1, Denise Echelard1, Thomas S. Hatsukami4 1University of Washington, School of Medicine, Seattle, WA, USA; 2PLA General Hospital, Beijing, China; 3The Mountain Whisper Light, Seattle, WA, USA; 4University of Washington, School of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA. 1967.Longitudinal Study of Carotid Lumen/Plaque Measurements K. Craig Goodrich1, Andrew Alexander1, Marilyn C. Masiker1, Shandra Johnson1, Isaac Blatter1, Gregory Katzman1, Jay Tsuruda1, Dennis L. Parker1 1University of Utah, Salt Lake City, UT, USA. 1968.A Quick Multi-Contrast High Resolution MR Protocol for Screening Atherosclerotic Carotid Artery and Brain Ischemic Events Cai Jianming1, Youquan Cai1, Yuangui Gao1, Shuihui Chen1, Chun Yuan2 1Chinese PLA General Hospital, Beijing, P.R.China; 2University of Washington, Medical Center, Seattle, Wa, USA. 1969.Spiral Coronary Wall Imaging: Patient Studies Michael V. McConnell1, Craig H. Meyer1, Eric J. Putz1, Dwight G. Nishimura1, Bob S. Hu1 1Stanford University, Stanford, CA, USA. 1970.A Contour Shape Similarity Measurement Method for the Comparison of In Vivo and Ex Vivo MR Images of Human Carotid Atherosclerotic Vessel Ying Luo1, Nayak L. Polissar2, Chun Yuan1 1University of Washington, Seattle, WA, USA; 2The Mountain-Whisper-Light Statistical Consulting, Seattle, WA, USA. 1971.A Simple Measure of Flow Shear and Turbulence James G. Pipe1 1Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Flow Quantitation and Evaluation Hall 4 Thursday: 13:30 - 15:30 1972.Phase Contrast MRI With High Temporal Resolution by View Sharing Michael Markl1, Jürgen Hennig1 1University of Freiburg, Freiburg, Germany. 1973.Accurate Flow Measurements With Segmented k-Space MR Phase Velocity Mapping Haosen Zhang1, Sandra S. Halliburton2, James R. Moore3, Orlando P. Simonetti3, Paulo Schvartzman2, Richard D. White2, George P. Chatzimavroudis1 1Cleveland State University, Cleveland, OH, USA; 2The Cleveland Clinic Foundation, Cleveland, OH, USA; 3Siemens Medical Systems, Chicago, IL, USA. 1974.In-Plane Flow Mapping with Two-Dimensional Velocity-Sensitive Spin Preparation Han Wen1 1National Institutes of Health, Bethesda, MD, USA. 1975.High-Speed Measurement of Wave Speed and Vessel Wall Compliance using a Novel MR Pulse Sequence Charles L. Dumoulin1, Ray F. Lee2, Kate McLeish3, Colin G. Caro4 1G. E. Corporate R & D Center, Niskayuna, NY, USA; 2General Electric Co., USA; 3King's College London, London, UK; 4Imperial College of Science, Technology and Medicine, University of London, London, UK. 1976.The Effect of Echo Time, Flip Angle and Orientation on EPI Signals for Constant and Pulsatile Flow Donald W McRobbie1, Christopher N Guy2, Rebecca Quest3 1Imperial College, Charing Cross Hospital, London, England, UK; 2Imperial College, London, UK; 3Charing Cross Hospital, London, UK. 1977.Automated Quantitation of the ISMRM Multi-Center Flow Phantom Trial using Pulsatility-Based Segmentation (PUBS) Method Noam Alperin1, Sang H Lee1, Paul E Summers2 1University of Illinois at Chicago, Chicago, IL, USA; 2King's College London, London, England, UK. 1978.Anti-Aliasing Acquisition for Velocity Encoded CINE Qing-San Xiang1 1University of British Columbia, BC Children's Hospital & St. Paul's Hospital, Vancouver, BC, Canada. 1979.Real-Time Prescription by Three-Dimensional Vessel Localization in Cine Phase-Contrast Flow Measurement Meide Zhao1, Fady T Charbel1 1University of Illinois at Chicago, College of Medicine, Chicago, IL, USA. 1980.Set-up and Validation of a MR-compatible Flow Phantom Andreas Kuring1, Jürgen R. Reichenbach1, Matthias E. Bellemann2, Tarek Azhari1, Werner A. Kaiser1 1Friedrich-Schiller-Universität Jena, Jena, Germany; 2University of Applied Sciences, Jena, Germany. 1981.MRI Measurements of Intracranial Volume Change: A Phantom Study Noam Alperin1, Yasha Kadkhodayan1, Francis Loth1, Ramana Yedavalli1 1University of Illinois at Chicago, Chicago, IL, USA. 1982.Comparison of WSS Vector Measurement based on PC-MRI with Computational Fluid Dynamic Uwe Köhler1, Malcolm Robertson2, Quan Long3, X. Yun Xu3, Ian Marshall2, Peter R. Hoskins2 1Western General Hospital, Edinburgh, Scotland, UK; 2Edinburgh University, Edinburgh, Scotland, UK; 3Imperial College, London, England, UK. 1983.Resolution-Independent Flow Velocity Measurement in Small Vessels with Negligible Background Signal Remko van der Weide1, Chris J.G. Bakker1, Max A. Viergever1 1University Medical Center, Utrecht, The Netherlands; 1984.Characterizing Flow in Hemodialysers using MRI Churn K Poh1, Peter A. Hardy1, William R. Clark2, Dayong Gao1 1University of Kentucky, Lexington, KY USA; 2Baxter Healthcare Corp, McGaw Park, IL, USA. 1985.MR Phase-Contrast Flow Measurements in Metallic Vascular Stents; Flow Phantom Study in Stents Made of Nitinol and Stainless Steel-316. Jacqueline van Holten1, Patrik Kunz2, Peter MT Pattynama1, Albert de Roos2, Lukas C van Dijk1 1University Hospital Rotterdam, Rotterdam, The Netherlands; 2Leiden University Medical Center, Leiden, The Netherlands. Chest MR Imaging Hall 4 Monday: 14:00 - 16:00 1986.Oxygen-Enhanced MR Ventilation Imaging Reflects Diffusion Capacity of the Lung Yoshiharu Ohno1, Hiroto Hatabu2, Katsunobu Takenaka3, Y. Watanabe4, S. Adachi4, Kazuro Sugimura5 1Department of Radiology, Kobe City, Japan; 2University of Pennsylvania, Philadelphia, PA, USA; 3Gifu City, Japan; 4University of Kobe, Kobe, Hyogo, Japan; 5Shimane Medical University, Izumo, Japan; 1987.Three-Dimensional (3D) Contrast-Enhanced MR Perfusion Imaging and MR Angiography: Utility for Management of Pulmonary Arterio-Venous Malformations (PAVM)for Embolotherapy Yoshiharu Ohno1, H. Hatabu2, D. Takenaka3, Y. Watanabe3, S. Adachi3, H. Hirota3, K. Sugimura3 1University of Pennsylvania, University of Kobe, Philadelphia, PA, USA; 2University of Pennsylvania Medical Center, Philadelphia, PA, USA; 3University of Kobe, Hyogo College of Medicine, Japan. 1988.Cystic Fibrosis - Combined Functional and Anatomical Lung 1H Imaging: Preliminary Results and Important Observations Peter Jakob1, Tungte Wang1, H. Hebestreit1, A. Hebestreit1, G Schultz1, Axel Haase1, D. Hahn1 1University of Würzburg, Würzburg, Germany. 1989.Improvement of Image Quality in 2D/3D Half-Fourier FSE with RF Subencoding Acquisition - Clinical Applications in Thoracic Imaging Yasuyuki Kobayashi1, Osamu Tanaka1, Naoya Imai1, Tetsuya Yokomizo1, Yoshio Machida2, Miguel Angel Gonzalez Ballester2, Tomoko Miyata3, Kenji Yodo3 1Omiya Medical Center, Jichi Medical School, Omiya, Japan; 2Medical Systems R&D Center, Toshiba, Tochigi, Japan; 3Toshiba Medical Systems Co., Ltd., Tokyo, Japan. 1990.Pulmonary MR Angiography with Contrast Agent at 4.0 Tesla: A Preliminary Result Hidemasa Uematsu1, Lawrence Dougherty1, Masaya Takahashi1, Yoshiharu Ohno1, M. Nakatsu1, Hee Kwon Song1, Victor Ferrari1, Warren Gefter1, Mitchell Schnall1, Hiroto Hatabu1 1University of Pennsylvania, Philadelphia, PA, USA. 1991.A New Perfusion Weighted Image of the Lung without Contrast Material: Difference of Parenchymal Signal Intensity between Systolic and Diastolic Phases Yasuyuki Kurihara1, Yoshiko K Yakushiji1, Hiroaki Arakawa, Ichiro Tani, Hiroshi Niimi, Junichi Matsumoto, Yasuo Nakajima, Kumiko Hirose, Minako Higashi, Mitsue Miyazaki2 1St. Marianna University, School of Medicine, Kawasaki City, Japan; 2Toshiba Corp. - Nasu Works, Tochigi, Japan. 1992.Flow-Sensitive MR Imaging of the Lung using ECG-Gated Half-Fourier FSE at 0.5T and 1.5T Satoshi Kawanami1, Katsumi Nakamura1, Mizue Miyazaki2, Satoshi Sugiura2, Akiyoshi Yamamoto3, Touru Sato1, Keiko Kumamoto4, Matsufuji Yuka4, Hajime Nakata2 1University of Occupational and Environmental Health, Kitakyusyu, Fukuoka Japan; 2Toshiba Medical Systems R&D Center, Otawara, Tochigi Japan; 3Kyoritsu Hospital, Japan; 4Toshiba Medical Company, Japan. 1993.Exploiting the Cardiac-Dependent Signal Intensity in the Lung for MR Pulmonary Imaging Shella D Keilholz-George1, Eduard E. De Lange1, Jack Knight-Scott1 1University of Virginia, Charlottesville, VA, USA. 1994.Absolute Quantification of Pulmonary Perfusion Using Dynamic T1 Contrast Enhanced MRI: Performance of Singular Value Decomposition (SVD) Deconvolution Technique at Low Contrast to Noise (CNR) Magalie Viallon1, Wolfgang Schreiber1, Melanie Schmitt1, Manfred Thelen1, Hanz-Ulrich Kauczor1 1Johannes Gutenberg Universität, Mainz, Germany. 1995.Demonstration of Perfusion Defect for Pulmonary Embolism in a Canine Model: Feasibility of ECG-gated 2D half-Fourier FSE Nobuhiko Ogasawara1, Kazuyoshi Suga1, Katsuyoshi Ito1, Shinji Koike1, Keiko Kishimoto1, Munemasa Okada1, Naofumi Matsunaga1 1Yamaguchi University, School of Medicine, Ube, Yamaguchi Japan. 1996.Comparison of First-Pass Gd-DOTA and FAIRER Perfusion Imaging in a Rabbit Model of Pulmonary Embolism Shella D Keilholz-George1, Vu M Mai2, Stuart S Berr1, Naomi Fujiwara1, Klaus D Hagspiel1 1University of Virginia, Charlottesville, VA, USA; 2Evanston Northwestern Healthcare, Evanston, IL, USA. 1997.Imaging Perfusion Deficit in a Pulmonary Embolism Model: Comparison of FAIRER and PS-SIR Techniques Vu M. Mai1, Klaus Hagspiel2, Qun Chen1, Alexander A. Bankier3, Naomi Fujiwara2, John Christopher2, Stuart S. Berr2, Shella Keilholz-George2, Robert R. Edelman1 1Evanston Hospital, Evanston Northwestern Healthcare, Evanston, IL, USA; 2University of Virginia, Charlottesville, VA, USA; 3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 1998.Rapid 1H T1-Mapping of the Human Lung Tungte Wang1, Claudia Hillenbrand1, G. Schultz1, D. Hahn1, Axel Haase1, P. M. Jakob1 1University of Würzburg, Würzburg, Germany. 1999.STIR & MTC Enhanced 1H Magnetic Resonance Imaging of Human Lung Peter Jakob1, T. Wang1, G. Schultz1, Axel Haase1, D. Hahn1 1University of Würzburg, Würzburg, Germany. 2000.Single-Shot Half-Fourier RARE Sequence with Ultra-Short Inter-Echo Spacing of the Lung Yoshiharu Ohno1, Koichi Oshio2, Hidemasa Uematsu3, M. Nakatsu4, Y. Takahashi5, K. Nagasawa5, Warren Gefter4, Hiroto Hatabu4 1Department of Radiology, Kobe City, Japan; 2Harvard University, Brigham and Women's Hospital, Boston, MA, USA; 3Fukui Medical School, Fukui, Japan; 4University of Pennsylvania Medical Center, Philadelphia, PA, USA; 5GE Yokagawa Medical System, Hino, Tokyo, Japan. 2001.Assessment of Oleic Acid-Injured Canine Lungs with Dynamic Perfusion MRI Kazuyoshi Suga1, Nobuhiko Ogasawara1, Naofumi Matsunaga2 1Yamaguchi University School of Medicine, Ube, Japan; 2Yamaguchi University School of Medicine, Yamaguchi, Japan. 2002.Distinguishing Extra- and Intra-Pulmonary Gas using Xenon Polarization Transfer Contrast (XTC) Kai Ruppert1, John P. Mugler III1, Klaus D. Hagspiel1, Talissa A. Altes1, Jaime F. Mata1, James R. Brookeman1, Bastiaan Driehuys2, Ashok Menon3, Aditya K. Kaza1, Irving L. Kron1 1University of Virginia, School of Medicine, Charlottesville, VA, USA; 2Nycomed-Amersham Imaging, Durham, NC, USA; 3IGC-Medical Advances, Milwaukee, WI, USA. 2003.Hyperpolarized Helium-3 MR Imaging of Lung Ventilation Changes Following Airway Mucus Clearance Treatment in Cystic Fibrosis Talissa Altes1, Deborah K. Froh1, Michael Salerno1, Christopher D. Cook1, Jaime Mata1, John P. Mugler III1, Eduard E. De Lange1, James R. Brookeman1 1University of Virginia, Charlottesville, VA, USA. 2004.Hyperpolarized Helium-3 MR Imaging, Computed Tomography and Spirometry Assessments in Patients with Emphysema: Comparison with Histology. Eduard E. De Lange1, Mark H. Stoler1, Jonathon D. Truwit1, Thomas M. Daniel1, David R. Jones1, Talissa Altes1, Mark R. Conaway1, John P. Mugler III1, James R. Brookeman1 1University of Virginia, Charlottesville, VA, USA. 2005.MRI of Lung Parenchyma in Small Rodents In Vivo at 4.7 T: Detection and T2* Determination with a Gradient-Echo Sequence Nicolau Beckmann1 1Novartis Pharma, Ltd., Basel, Switzerland. 2006.Ventilation-Perfusion Imaging of Human Lung Using Oxygen-Enhanced and Arterial Spin Labeling Techniques Vu M. Mai1, Alexander A. Bankier2, Robert R. Edelman1, Qun Chen1 1Evanston Hospital, Evanston Northwestern Healthcare, Evanston, IL, USA; 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 2007.Flow-Sensitive MR Imaging of the Lung using ECG-Gated Half-Fourier FSE: Subtraction at Different Phases of Pulmonary Circulation Satoshi Kawanami1, Katsumi Nakamura1, Mizue Miyazaki2, Satoshi Sugiura2, Youichi Ishino1, Keiko Kumamoto3, Yuka Matsufuji3, Hajime Nakata1 1University of Occupational and Environmental Health, School of Medicine, Kitakyusyu, Fukuoka Japan; 2Toshiba Medical Systems R&D Center, Otawara, Tochigi Japan; 3Toshiba Medical Company, Japan. 2008.Lung Biomechanics via Non-Rigid Registration of Serial MR Images Hiroto Hatabu1, Yoshiharu Ohno2, Hidemasa Uematsu3, M. Nakatsu1, Hee Kwon Song1, Koichi Oshio4, Warren Gefter1, James C. Gee1 1University of Pennsylvania, Philadelphia, PA, USA; 2Department of Radiology, Kobe City, Japan; 3Fukui Medical School, Fukui, Japan; 4Harvard University, Brigham and Women's Hospital, Boston, MA, USA. 2009.Optical Flow Analysis of Chest Wall Motion Tae Iwasawa1, Seiichirou Kagei2, Toshiyuki Gotoh2, Yasuhiro Yoshiike1, Yew Kurabayashi2, Hiroaki Kurihara3, Kimihiko Saito3 1Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan; 2Yokohama National University, Yokohama, Kanagawa Japan; 3Yokohama City University, Yokohama, Kanagawa Japan. 2010.Mapping Regional Pulmonary Expansion in Patients with Sarcoidosis Using Tagging MRI Vitaly Napadow1, Phillip Boiselle2, Vu Mai3, Richard Gilbert1, Robert Edelman3, Qun Chen3 1Massachusetts Institute of Technology, Cambridge, MA, USA; 2Beth Israel Deaconness Medical Center, Boston, MA, USA; 3Northwestern University, Evanston, IL, USA. 2011.Resolution Enhancement in Lung 1H Imaging Using A Partially Parallel Acquisition Strategy Peter Jakob1, Mark Griswold1, Robin Heidemann1, J. Ming2, Mathias Nittka1, B. Kiefer1, Axel Haase1 1Universität Würzburg, Würzburg, Germany; 4Siemens Medical Engineering Group, Erlangen, Germany. MR Imaging of the Abdomen Hall 4 Monday: 14:00 - 16:00 2012.SENSE in the Abdomen and Pelvis David J Larkman1, Mark Bydder1, Nandita DeSouza1, Andreanna D Williams1, Frank H Bearden2, Joseph V Hajnal1 1Imperial College, School of Medicine, Hammersmith Hospital, London, UK; 2Marconi Medical Systems, Clevland, OH, USA. 2013.High Definition Whole Body Imaging at 3 Tesla Steve Roberts1, Alan Freeman1, Philip Murphy1, Robert Gauss2, Michael Burl2 1Marconi Medical Systems UK Ltd., Farnham, Surrey, UK; 2Marconi Medical Systems, Highland Heights, OH, USA. 2014.Whole Body Fast Spin Echo Imaging at Three Tesla J. K. Mendes1, N. DeZanche1, Derek J Emery1, Alan Wilman1 1University of Alberta, Edmonton, Alberta, Canada. 2015.Diffusion Weighted MR Imaging of the Abdomen with Pulse Triggered Single Shot Sequences P. Mürtz1, D. Pauleit1, S. Flacke1, F. Träber1, J. S. van den Brink2, J. Gieseke2, H. H. Schild1 1University of Bonn, Bonn, Germany; 2Philips Medical Systems, Best, The Netherlands. 2016.A T2-Weighted Radial MRI Method for Imaging the Abdomen. M. I. Altbach1, R. J. Theilmann1, M. Kono1, T. P. Trouard1, E. K. Outwater1, A. F. Gmitro1 1University of Arizona, Tucson, AZ, USA. 2017.Breath-hold T2-Weighted Imaging of Hepatic Lesions by using Fast Recovery Fast Spin-Echo Sequence Tonsok Kim1, Takamichi Murakami1, Satoru Takahashi1, Masatoshi Hori2, Horonobu Nakamura1, Manabu Takamura1 1Osaka University Medical School, Suita-City, Osaka Japan; 2Kyoto, Japan. 2018.Small Hepatic Lesions in Patients Having Malignancy: Diagnostic Capability of FLAIR-HASTE MR Imaging Masayasu Yasui1, Katsuyoshi Ito1, Shinji Koike1, Nobuhiko Ogasawara1, Keiko Kishimoto1, Naofumi Matsunaga1 1Yamaguchi University School of Medicine, Ube, Yamaguchi Japan. 2019.Fatty Liver Quantification with Line Scan Echo Planar Spectroscopic Imaging (LSEPSI) Hiroshi Shinmoto1, Koichi Oshio2, Robert Mulkern3, Yuji Yuasa1, Akihiro Tanimoto1, Masahiro Jinzaki1, Shigeo Okuda1, Sachio Kuribayashi1 1Keio University, Tokyo, Japan; 2Harvard University, Brigham and Women's Hospital, Boston, MA, USA; 3Harvard University, The Children's Hospital, Boston, MA, USA. 2020.Differentiation Between Hepatic Cyst and Hemangioma: The Value of Breath-hold, Multisection Fluid-attenuated Inversion-Recovery (FLAIR) Imaging using HASTE Sequence Katsuyoshi Ito1, Hajime Okazaki1, Shinji Koike1, Ayame Shimizu1, Keiko Kishimoto1, Masayasu Yasui1, Nobuhiko Ogasawara1, Kazuyoshi Suga1, Naofumi Matsunaga1 1Yamaguchi University School of Medicine, Ube, Yamaguchi Japan. 2021.T2-Weighted MRI of the Liver: Comparison of Fast Recovery Fast Spin Echo and Single Shot Fast Spin Echo Sequences Maricela Contreras1, Gregory T. Sica1, Kelly H. Zou1, Robert V. Mulkern1, Clare M. Tempany1 1Brigham and Women's Hospital, Boston, MA, USA. 2022.Characterization of Hepatic Tumors Containing Fat: MR Imaging Findings with Pathologic Correlation Huiyi Ye1 1Beijing, P.R.China. 2023.Comparison of Inversion Recovery Gradient-and Spin-Echo(IR-GraSE) and Turbo-Spin-Echo (TSE) Techniques in the Diagnosis of Hepatic Focal Lesions at 1.5T Kyu-Tong Yoh1, Ji-Kon Ryu1, Kwang-Hyun Ryu1, Woo-Hyun Ahn1 1Dae Jin Medical Center, Pundang Jesaeng General Hospital, Kyonggi-do Korea. 2024.Hepatic Kinetics of MRI Contrast Agents in the Isolated Perfused Rat Liver Catherine Pastor1, Jean-Paul Vallée1, Joachim Mayer2, Sibylle Pochon3, Corinne Planchamp2, François Terrier1 1Geneva University Hospital, Geneva, Switzerland; 2Université de Lausanne, Lausanne, Switzerland; 3Bracco Research SA, Plan-Les-Ouates, Switzerland. 2025.Hypervascular Hepatic Lesions: Dynamic and Late Enhancement Pattern with Gd-BOPTA Giovanni Morana1, Luigi Grazioli2, Gunther Schneider3, Marco Testoni1, Menni Katiuscia2, Miles Kirchin4, Antonio Chiesa2, Carlo Procacci1 1University of Verona, Verona, Italy; 2University of Brescia, Brescia, Italy; 3Germany; 4Bracco SpA, Milano, Italy. 2026.Detection of Hepatocellular Carcinoma: Comparison of In-Phase and Out-Of-Phase Gradient Recalled Echo Dynamic MR Imaging Using Double-Echo FLASH Sequence during the Hepatic Arterial Phase Tomohiro Namimoto1, Yasuyuki Yamashita2, Akihiko Arakawa3, Naoko Tsunoda1, Kazuhiro Yoshizumi1, Yukinori Koga1, Mutsumasa Takahashi2 1Kumamoto National Hospital, Kumamoto, Japan; 2Kumamoto University, School of Medicine, Kumamoto, Japan; 3Kumamoto University, Kumamoto, Japan. 2027.MR Imaging Follow-Up of Hepatic Tumors after Radiofrequency Ablation Jeong-Min Lee1, Chong-Soo Kim1 1Chonbuk National University Hospital, Chonbuk National University, Chonju, Chonbuk, South Korea. 2028.Cirrhosis: A Modified Caudate-to-Right-Lobe Ratio Hitomi Awaya1, Donald G Mitchell1, Tamotsu Kamishima1, George Holland1, Katsuyoshi Ito2 1Thomas Jefferson University Hospital, Philadelphia, PA, USA; 2Yamaguchi University School of Medicine, Ube, Yamaguchi Japan. 2029.Small Early Enhancing Hepatic Lesions in Patients with Cirrhosis: Evaluation with Serial Contrast-enhanced Dynamic MR Imaging Ayame Shimizu1, Katsuyoshi Ito1, Shinji Koike1, Keiko Kishimoto1, Naofumi Matsunaga1 1Yamaguchi University School of Medicine, Ube, Yamaguchi Japan. 2030.Evaluation of Gastro-Esophageal Varices after Endoscopic Sclerotherapy with MR Angiography Satoru Kitano1, Shinji Hirohashi1, Kouji Ueda2, Nagaaki Marugami1, Hideo Uchida1, Hajime Ohishi1 1Nara Medical University, Koryo, Japan; 2Higashiosaka City General Hospital, Kashihara, Japan. 2031.Automatic Classification of Texture Analysis and 31P MRS Parameters of Cirrhotic Liver Daniel Jirak1, Monika Dezortova2, Pavel Taimr1, Milan Hájek2 1Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 2IKEM, Prague, Czech Republic. 2032.Comparison between MnDPDP-Enhanced MR Imaging of the Liver and Hystological Assessment after Surgical Excision due to Chronic Liver Failure and/or Hepatocellular Carcinoma. 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Butty1, Klaus D. Hagspiel1, J. Fritz Angle1, Daniel A. Leung1, Alan H. Matsumoto1, David J. Spinosa1, Hilary A. Sanfey1, Robert G. Sawyer1, Christopher Mccullough1, Timothy L. Pruett1 1University of Virginia, Charlottesville, VA, USA.2058.Dynamic Three-Dimensional (3D) MR Renography: Preliminary Feasibility Studies Vivian S. Lee1, Henry Rusinek1, Peter Lee2, Glyn Johnson1, Joseph C. Veniero1, Gerhard Laub3, Glenn A. Krinsky1, Jeffrey C. Weinreb1 1New York University Medical Center, New York, NY, USA; 2Albert Einstein School of Medicine, Bronx, NY, USA; 3Siemens Medical Systems, Chicago, IL, USA. 2059.Analysis of Dynamic Three-Dimensional (3D) MR Renography: Regional Characterization by Multicompartmental Modeling Vivian S. Lee1, Henry Rusinek1, Sobin Kim2, Edward Leonard2, Peter Lee3, Glyn Johnson1 1New York University Medical Center, New York, NY, USA; 2Columbia University, New York, NY, USA; 3Albert Einstein School of Medicine, Bronx, NY, USA. 2060.Dual Phase Chemical Shift Imaging for Histological Diagnosis of Renal Cell Carcinoma: Evaluation by Subtraction Chemical Shift Mapping Makoto Amanuma1, Junji Tanaka, Kyoko Enomoto, Tsuneya Watabe2, Atsuko Heshiki1 1Saitama Medical School, Iruma, Japan; 2Tokyo, Japan. 2061.Kidney Perfusion Measurements with the FAIR Method: A Clinical Feasibility Study Norbert Karger1, Christopher Ahlers2, Carsten Liess1, C. Muhle1, Martin Heller1, Claus C Glueer1 1CAU Kiel, Kiel, Germany; 2University of Kiel, Kiel, Germany. 2062.Comprehensive MR Evaluation of Renal Donors: Accuracy and Cost Comparison with Conventional Imaging Pranav P. Patel1, Susanne Shamsolkottabi2, Melody A. Denson2, Stephen C. Rayhill2, You Min Wu2, Alan H. Stolpen1 1University of Iowa Hospitals & Clinics, Iowa City, IA, USA; 2University of Iowa, Iowa City, IA, USA. 2063.Assessment of Renal Structural and Functional Abnormalities After Acute Renal Vein Occlusion in Dogs with Contrast-Enhanced Dynamic Echo-Planar MRI Kazuyoshi Suga1, Nobuhiko Ogasawara1, Naofumi Matsunaga1 1Yamaguchi University School of Medicine, Ube, Japan. 2064.Dynamic, Fat-Suppressed, Contrast-Enhanced Imaging of Renal Cell Carcinoma using Shared Prepulses (SHARP) Richard Mc Carthy1, Frank Miller1, Scott Pereles1, Orlando Simonetti2, Gerhard Laub2, Paul Finn1 1Northwestern University Medical School, Chicago, IL. USA; 2Siemens Medical Systems, Chicago, IL, USA. 2065.Kidney MR Signal Changes Induced by Breathing Carbogen Gas Yantian Zhang1, Hugh Preas1, Christopher Wilcox2, Peter Choyke1 1National Institutes of Health, Bethesda, MD, USA; 2Georgetown University Medical Center, Washington, DC, USA. 2066.Wilms' Tumor. The Accuracy of MRI in Detection of the Preoperative Chemotherapy Efficiency and MRI - Histopathological Comparison Victor Josef Dombrovsky1, Ellen Vladimirovna Polevichenko1, Anna Vitalievna Shepeleva1 1Rostov State Medical University, Rostov-on-Don, Rostov, Russia. 2067.Assessment of Regional Renal Tubular Dysfunction with Gadolinium-Enhanced Dynamic Echo-Planar Imaging: Experimental Study. Nobuhiko Ogasawara1, Kazuyoshi Suga1 Katsuyoshi Ito1, Shinji Koike1, Naofumi Matsunaga1 1Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan. Genitourinary and Pelvic MR Imaging Hall 4 Monday: 14:00 - 16:00 2068.Determination of High-Risk Regions for Recurrence of Cervical Carcinoma after Wertheim-Meigs Surgery in a 3D-MRI and CT Based Coordinate System Claus Peter Heussel1, Gero Teichmann2, Helle Dammann3, Manfred Thelen3, Michael Hoeckel2, Hans-Ulrich Kauczor4 1Mainz, Germany; 2University Leipzig, Leipzig, Germany; 3Johannes Gutenberg-University, Mainz, Germany; 4Universitaet Mainz, Mainz, Germany. 2069.Assessment of Early Stage Endometrial Carcinoma using T2-Weighted and Gd-enhanced T1-Weighted MR Imaging Eun-Jung Lee1, Jae-Young Byun1, Bum-Soo Kim1, Sung-Eun Nam Koong1, Bo-Young Choe1, Tae-Suk Suh1, Hyoung-Koo Lee1, Kyung-Sub Shinn1 1Kang-nam St.Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea. 2070.The Role of MRI in the Assessment and Follow-Up of Patients Undergoing Uterine Fibroid Embolisation. Allan W Reid1, Michael W Sproule1, Giles H Roditi1 1Glasgow Royal Infirmary, Glasgow, Scotland, UK. 2071.Uterine Peristalsis on Ultrafast MR Imaging Asako Nakai1, Kaori Togashi1, Hisataka Kobayashi1, Akira Hiraga1, Koji Koizumi1, Hiroyuki Ueda1, Toshihide Yamaoka1, Masako Kataoka1, Junji Konishi1 1Kyoto University., Graduate School of Medicine, Kyoto, Japan. 2072.Myometrial Contractility using SENSE Imaging Andreanna D Williams1, David J Larkman1, Jan J Brosens2, Mark Bydder1, Joseph V Hajnal1, Nandita deSouza1 1Imperial College, Hammersmith Hospital, London, UK; 2Hammersmith Hospital, London, England, UK. 2073.Uterine Artery Embolizition for Symptomatic Fibroids and Adenomyosis: Assessment by MRI. Reena Chetna Jha1, Junko Takahama2, Susan Ascher1, Izumi Imaoka3, James B Spies1 1Georgetown University, Georgetown University Hospital, Wasington,, DC, USA; 2Georgetown University, Nara Medical University, Washington, DC, USA; 3Shimane Medical University, Tenri, Japan. 2074.Uterine Pseudolesions Related to Contraction: Characterization with Multiphase-Multislice T2-Weighted MRI Takayuki Masui1, Motoyuki Katayama1, Shigeru Kobayashi1, Tatsuhiko Ito1, Satoru Nakayama1, Harumi Sakahara2, Atsushi Nozaki3, Hiroyuki Kabasawa3 1Seirei Hamamatsu General Hospital, Hamamatsu, Japan; 2Hamamatsu University School of Medicine, Hamamatsu, Japan; 3GE Yokogawa Medical, Hino, Japan. 2075.IMRI Guided Cryoablation of Uterine Leiomyoma Patrick Ellison Sewell Jr.1, Bryan D. Cowan1 1Univ. of Mississippi Medical Center, Jackson, MS, USA. 2076.Quantification of Short Term Prostatic Motion due to Bladder Filling Peter Gibbs1, Pedro A Kassinda1, Andy W Beavis2, Lindsay W Turnbull1 1Hull Royal Infirmary, Hull, England, UK; 2Princess Royal Hospital, Hull, England,UK. 2077.Differentiation of Prostatic Cancer from Benign Prostatic Lesions Using Dual Echo Dynamic Contrast MRI Satoshi Muramoto1, Hirohiko Kimura1, Hidemasa Uematsu1, Yoshiyuki Ishimori1, Yasutaka Kawamura1, Tsuyoshi Matsuda2, Norihiro Sadato1, Yoshiharu Yonekura1, Harumi Ito1 1Fukui Medical University, Fukui, Japan; 2Tokyo, Japan. 2078.Role of Diffusion-weighted MRI in the Examination of Prostatic Carcinoma and Benign Prostatic Hyperplasia Munetaka Matoba1, Hisao Tonami1, Hajime Yokota1, Masaaki Kuginuki1, Itaru Yamamoto1 1Kanazawa Medical University, Ishikawa, Japan. 2079.Textural Analysis of the Prostate using Co-occurence matrices Adrian Knowles1, Oscar Brihuega-Moreno2, Peter Gibbs2, Lindsay W Turnbull2 1Philips Medical Systems, Best, The Netherlands; 2Hull Royal Infirmary, Hull, East Yorkshire. UK. 2080.The Effect of Maternal Posture on Pelvic Outlet MR Measurements Sven Claude André Michel1, Borut Marincek1, Annett Rake1, Karl Treiber1, Rabih Chaoui1, Burkhardt Seifert1, Rahel Kubik-Huch1 1University Hospital, Zurich, Switzerland. 2081.Fetal MR Imaging with a Half-Fourier Rapid Acquisition with Relaxation Enhancement Sequence: The Value of 2D Single-Slice Hydrography and Cine-Display Kazuyuki Ohgi1, Makiko Toyoda1, Hiroyuki Yokote1, Takashi Furukawa1, Hiromi Akiyama2, Shouichirou Kimura2, Kouichirou Murata3, Katsuhito Gotoh4, Shuhei Takemoto4 1Japanese Red-Cross Medical Center, Shibuya-ku, Tokyo, Japan; 2Kasukabe-Shuwa Hospital, Saitama Japan; 3Kitazato-Institute Hospital, Tokyo Japan; 4Toshiba Medical Incorp., Tokyo, Japan. 2082.Antepartum Evaluation of Suspected Placenta Accreta: Is There a Role for MRI? Alan H. Stolpen1, Monzer Abu-Yousef1, Wendy F. Hansen1 1University of Iowa Hospitals & Clinics, Iowa City, IA, USA. 2083.Magnetic Resonance Imaging in Comparison with Ultrasound in Patients with Suspected Acute Diverticulitis: Initial Results of a Prospective Study Johannes Heverhagen1, Andreas Zielke2, Natascha Ishaque1, Thomas Bohrer2, Klaus J Klose2 1University Hospital Marburg, Marburg, Hessen, Germany; 2Philipps University, Marburg, Hessen, Germany. 2084.In Vivo and Ex Vivo MRI of Rat Testis: A Comparison with Some Conventional Measurements David G. Reid1, K. Kumar Changani1, Albert L. Busza1, Paul D. Hockings1, Nadeem Saeed1, Colin Fish1, Robert W. Greenhill1, Alan White1, David Templeton1 1SmithKline Beecham Pharmaceuticals, Welwyn, UK. 2085.MR Imaging Spectrum of Clear Cell Carcinoma of the Ovary Yui Kumatoriya1, Shinji Hirohashi2, Megumi Takewa3, Sachiko Miura4, Shoko Hara5, Takahiro Ito2, Satoru Kitano2, Takehiro Tanaka4, Akio Fukusumi4, Hajime Ohishi2, Hideo Uchida2 1Osaka Japan; 2Nara Medical University, Nara, Japan; 3Nissei Hospital, Japan; 4Hoshigaoka-Kouseinenkin Hospital, Japan; 5Saiseikai-tyuwa Hospital, Japan. 2086.Gonadal Veins: MR Imaging Findings in an Unselected Population. Alessandra Bettega Nascimento1, Donald Mitchell1, George Holland1 1Thomas Jefferson University, Philadelphia, PA, USA. Musculoskeletal MRI: Arthritis Hall 4 Wednesday: 13:30 - 15:30 2087.Meniscal Displacement of the Knee Between Extension and Flexion States of the Weight-bearing Knee: Evaluation with Open MRI Jin-Suck Suh1, Sang-Hoon Lee2, Gabrielle Bergman3, Garry E. Gold3, Kim Butts3 1Dept. of Diagnostic Radiology, Seoul, Korea; 2Yonsei University, Seoul, Korea; 3Stanford University, Stanford, CA, USA. 2088.MR Evaluation of Meniscal Allografts Randall M Mapes1, Stephen Hushek2, Albert Seow3, Robert Moser4, Neil Hoerter4, Sue Barber-Westin1, Frank R Noyes1 1Cincinnati Sportsmedicine Research and Education Foundation, Cincinnati, OH, USA; 2Norton HealthCare, Louisville, KY, USA; 3University of Louisville, School of Medicine, Louisville, KY, USA; 4Norton Hospital, Louisville, KY USA. 2089.Magnetic Resonance Microimaging of Murine Arthritis Bernard Dardzinski1, Vincent J. Schmithorst1, Scott K. Holland1, Gregory P. Boivin1, Tomoyuki Imagawa2, Shohei Wantanabe2, Raphael Hirsch2, Jerome M. Lewis3 1Children's Hospital Medical Center, Cincinnati, OH, USA; 2University of Cincinnati College of Medicine, Cincinnati, OH, USA; 3Advanced Magnetics, Inc., Cambridge, MA, USA. 2090.MR Microscopy of Articular Cartilage using a 1.0 T Permanent Magnet Portable MR System Hiroshi Yoshioka1, Tomoyuki Haishi1, Takaaki Uematsu1, Yoshimasa Matsuda1, Yuji Itai1, Katsumi Kose1 1University of Tsukuba, Tsukuba, Japan. 2091.In Vivo Contrast-Enhanced Micro MRI of Experimental Osteoarthritis in the Rabbit Knee Joint Lydia Wachsmuth1, Hans-Paul Juretschke2, Ruth Raiss2, Rolf Keiffer2, Nicole Kimmel3, Elmar Lindhorst3 1Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; 2Aventis Pharma Deutschland GmbH, Frankfurt a.M., Germany; 3Universitätsklinik Frankfurt a.M., Frankfurt a.M., Germany. 2092.Fast, High Resolution, High Contrast Magnetic Resonance Imaging of Articular Cartilage with 3D Fast Spin Echo Spirals Lawrence Frank1, Eric Wong2, Christine Chung1, Donald L. Resnick1 1University of California, San Diego, VA Medical Center, San Diego, CA, USA; 2University of California, San Diego, Thornton Hospital, La Jolla, CA, USA. 2093.Three Dimensional Driven Equilibirum Imaging of the Knee: Initial Clinical Experience Garry E. Gold1, Brian A. Hargreaves2, Christopher F. Beaulieu2, Dwight G. Nishimura2 1Stanford University and Palo Alto VA, Stanford, CA, USA; 2Stanford University, Stanford, CA, USA. 2094.Potential Use of T2 as a Measure of Articular Cartilage Degeneration and Osteoarthritis Srinka Ghosh1, Vikas Patel1, Lydia Kirstin Wachsmuth2, Michael Ries1, Sharmila Majumdar1 1UC San Francisco, San Francisco, CA, USA; 2Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. 2095.Assessment of Articular Cartilage Composition by T2, Diffusion and Magnetization Transfer Measurements at 1.5 T Lydia Wachsmuth1, Lubos Budinsky2, Srinka Ghosh2, Denis Grenier2, Sharmila Majumdar2 1University of Erlangen, Erlangen, Germany; 2University of California, San Francisco, San Francisco, CA, USA. 2096.Intermodality Registration of Articular Cartilage and Underlying Bone in the Knee Kevan Saidi1, David W Holdsworth1, Terry M. Peters1, Hua Qian1, Ravi S Menon1, Lisa M. F. Thain2, Alison R Spouge2, Alexandra Kirkley2 1The John P. Robarts Research Institute, London, ON, Canada; 2University of Western Ontario, London, ON. Canada. 2097.Reproducibility of In Vivo Cartilage T2 Profiles: Implication for Longitudinal Studies Timothy J. Mosher1, Harvey Smith1, Christopher Collins1, Bernard Dardzinski2, Vincent Schmithorst3, Michael B. Smith1 1Pennsylvania State University, Hershey, PA, USA; 2University of Cincinnati, College of Medicine, Cincinnati, OH, USA; 3Children's Hospital, Cincinnati, OH, USA. 2098.Reproducibility of Knee Cartilage Volume Measurements in Arthritis Patients Stephen J. Gandy1, Paul A Dieppe1, Iain Watt2, Alan D Brett3, Michael C Keen4, Rose A Maciewicz5, Christopher J Taylor3, John C Waterton5 1University of Bristol, Bristol, UK; 2United Bristol Healthcare NHS Trust, Bristol, UK; 3University of Manchester, Manchester, UK; 4United Bristol Healthcare Trust, University of Bristol, Bristol, UK; 5AstraZeneca, Alderley Park, Macclesfield, UK. 2099.Measurements of Diurnal Variations in Joint Stiffness in Rheumatoid Arthritis Richard Stephen Nicholas1, Nigel Davies2, Michael Shields3, Richard Jacoby4, William Vennart5 1Addenbrooke's Hospital, Cambridge, UK; 2University of Exeter, Exeter, UK; 3Searle Pharmaceuticals, High Wycombe, UK; 4Princess Elizabeth Orthapaedic Hospital, Royal Devon and Exeter Healthcare Trust, Exeter, UK; 5Pfizer Central Research, Sandwich, UK. 2100.Navigator Echo Based Motion Corrected Diffusion Imaging of Articular Cartilage In Vivo at 1.5 T Lubos Budinsky1, Lydia Wachsmuth2, Srinka Ghosh1, David Newitt1, Sharmila Majumdar1 1University of California, San Francisco, San Francisco, CA, USA; 2University of Erlangen, Erlangen, Germany; 2101.Orientation of Collagenous Network in Articular Cartilage U. Reibetanz1, G. Hanke1, T. Reinert1, T. Butz1, W. Gründer1 1University of Leipzig, Leipzig, Germany. 2102.The Role of Relaxation Times for Evaluation of Osteoarthritic Change and Weight Bearing Effect in Hip Articular Cartilage Takashi Nishii1, Atsuomi Kimura2, Nobuhiko Sugano1, Hideaki Fujiwara2, Hideki Yoshikawa1 1Osaka University Medical School, Suita, Osaka, Japan; 2School of Allied Health Sciences, Faculty of Medicine, Osaka University, Suita, Osaka, Japan. 2103.A Novel MRI Method for Assessing the Ingetrity of Articular Cartilage Umamaheswar Duvvuri1, Sagar Kudchodkar1, J. S. Leigh1, R. Reddy1 1University of Pennsylvania, Philadelphia, PA, USA. 2104.Quantifying Sodium in the Human Wrist In Vivo using MRI Arijitt Borthakur1, Erik M. Shapiro1, S. V. S. Akella1, R. R. Regatte1, J. Bruce Kneeland1, H. Ralph Schumacher1, Ravinder Reddy1 1University of Pennsylvania, Philadelphia, PA, USA. 2105.Characterisation By MRI Of Spontaneous Osteoarthritis Progression In The Guinea Pig Jean Tessier1, Jonathan Bowyer1, Nicola Brownrigg1, David Checkley1, Rose A Maciewicz1, John Waterton1 1AstraZeneca Mereside, Macclesfield, Cheshire, England, UK. 2106.The Effect Detachment from the Bone and Pressure on the Order of the Collagen Fibers in Cartilage Keren Keinan Adamsky1, Hadassah Shinar1, Gil Navon1 1Tel Aviv University, Tel Aviv, Israel. 2107.Determination of Stress Distribution in Articular Cartilage by Means of Intensity Shifts under Load G. Hanke1, U. Reibetanz1, W. Gründer1 1University of Leipzig, Leipzig, Germany. 2108.Mapping Proteoglycan Changes of Articular Cartilage by T1( Imaging at 4T Sarma V.S. Akella1, Ravinder Regatte1, Arijitt Borthakur1, Erik Shapiro1, Umamaheswar Duvvuri1, J. Bruce Kneeland1, John Leigh1, Ravinder Reddy1 1University of Pennsylvania, Philadelphia, PA, USA. 2109.A Proton NMR Study of the Molecular Motion of Human Normal and Psoriatic Stratum Corneum Cornelia Laule1, C. L. Chia1, Irene Vavasour1, Alex MacKay1, C. Neil Kitson1 1University of British Columbia, Vancouver, BC, Canada. Musculoskeletal MRI: Muscle Hall 4 Wednesday: 13:30 - 15:30 2110.Comparison of Perfusion Measurement Using Contrast Enhanced MRI with Microsphere Blood Flow Measurement in Rat Hindlimb Muscle Yanping Luo1, Jerry L. Wessale1, Vincent P. Hradil1, Jason A. Segreti1, Kurt M. Mohning1, Merrill E. Nuss1, Sandra E. Burke1, Bryan F. Cox1 1Abbott Laboratories, Abbott Park, IL, USA; 2111.Strain Measurements in Human Triceps Surae Muscles-Tendon Complex (TSMC) In Vivo during Isometric Contraction. Shantanu Sinha1, Alexander Lai1, John Hodgson1, Reggie V Edgerton1 1University of California, Los Angeles, Los Angeles, CA, USA. 2112.High-Resolution MRI to Assess Skeletal Muscle Damage after Controlled Compressive Loading E.M.H. (Marielle) Bosboom1, Carlijn V.C. Bouten1, Cees W.J. Oomens1, Frank P.T. Baaijens1, Klaas Nicolay2 1Eindhoven University of Technology, Eindhoven, The Netherlands; 2Utrecht University, Utrecht, The Netherlands. 2113.Quantitative Analysis of T1 Weighted MRI of Skeletal Muscle in Autosomal Recessive Limb Girdle Muscular Dystrophy Matthew L. Bell1, Bharat Biswal1, John Ulmer2 1Medical College of Wisconsin, Milwaukee, WI, USA; 3Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee, WI, USA. 2114.Early Myositis Ossificans in Spinal Cord Injury James L Fleckenstein1, Lisa-Ann Wuermser1, Seckin O. Ulualp1, Kathy L Norman1 1University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. 2115.MR Signal Characteristics Of Heterotopic Ossification: Emphasis On Location In Anatomic Bursae Hans Peter Ledermann1, Mark Schweitzer1, William Morrison1 1Thomas Jefferson University, Philadelphia, PA, USA. Musculoskeletal MRI: Bone Hall 4 Wednesday: 13:30 - 15:30 2116.Maximal Entropy as a Predictor of Trabecular Bone Strength from High-Resolution MR Images Laurent Pothuaud1, David C. Newitt1, Pierre Levitz2, Sharmila Majumdar1 1University of California, San Francisco, San Francisco, CA, USA; 2Centre de Recherche sur la Matiere Divisee, Orleans, France. 2117.Diffusion-Weighted MRI and ADC Measurement of Tumoral Bone Marrow Antoine Feydy1, Jean-Luc Drape, Christophe Argaud2, Thierry Diche, Geraldine Revelon, Joël Costes, Alain Chevrot 1Hôpital Beaujon, Clichy, France; 2G. E. Medical Systems, Buc, France. 2118.Diffusion of Exchangeable Water in Bone Maria Fernandez-Seara1, S. L. Wehrli2, Felix Wehrli1 1University of Pennsylvania, Philadelphia, PA, USA; 2Children's Hospital of Pennsylvania, Philadelphia, PA, USA. 2119.Reproducibility of (-MRI-based Trabecular Bone Structure Measurement in the Distal Radius and Distal Tibia Felix Wehrli1, Richard Henry Weening1, Bryon Gomberg1, S. N. Hwang1, Hee Kwon Song1, A. C. Wright1 1University of Pennsylvania, Philadelphia, PA, USA. 2120.Bone Assessment of Men by 1.5T Magnetic Resonance Imaging Jo-Chi Jao1, Po-Chou Chen2, Yeu-Sheng Tyan3, Sin-Kao Chai4, Ming-Ming Wu3 1Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; 2I-Shou University, Kaoshiung, Taiwan, ROC; 3Armed Forces Taichung General Hospital, Taichung, Taiwan, ROC; 4Chungtai Institute of Health Sciences and Technology, Taichung, Taiwan, ROC. 2121.Use of 1H MRS of Vertebra In Vivo in Determining Bone Weakening Chin-Shoou Lin1, Hatice Hatipoglu1, Dieter Schellinger1 1Georgetown University Medical School, Washington, DC, USA. 2122.Evaluation of Trabecular Bone Quality In Vivo by Means of Multiple Spin Echoes Imaging at 1.5 T Silvia Capuani1, Gisela Hagberg2, Fabrizio Fasano3, Alessandro Castriota-Scanderbeg3, Bruno Maraviglia1, Jerome N. Sanes4 1University of Rome "La Sapienza", Rome, Italy; 2Scientific Institute of Foundation, Roma, Italy; 3IRCCS S.Lucia, Rome, Italy; 4Brown University, Providence, RI, USA. 2123.Influence of Zero-Filling for Trabecular Structure Assessment Using High-Resolution MRI in Lumbar Vertebrae Olivier Beuf1, Lis Mosekilde2, Sharmila Majumdar3 1Université Claude Bernard Lyon - CPE, Villeurbanne, France; 2University of Aarhus, Aarhus, Denmark; 3University of California, San Francisco, San Francisco, CA, USA. 2124.The Effects of Corticosteroid on Trabecular Bone Architecture, Growth Plate and Bone Marrow Are Only Partially Reversible: An MRI/MRS in the Rabbit M. Takahashi1, Felix Wehrli1, Luna Hilaire1, B. Zemel2 1University of Pennsylvania, Philadelphia, PA, USA; 2Children's Hospital of Pennsylvania, Philadelphia, PA, USA. 2125.Detection of Subchondral Fractures in Osteonecrosis of the Femoral Head: Comparison of Conventional Radiography, CT and MRI Kathryn Jane Stevens1, Caroline Tao1, Jan Vandevenne1, Shi-Uk Lee1, Natalie Salem1, Calise Cheng1, Alexandre Valentin-Opran2, Philipp Lang1 1Stanford University Medical Center, Stanford, CA, USA; 2Genetics Institute, MA, USA. 2126.Endochondral Bone Formation Studied by Proton NMR Microscopy Kimberlee Potter1, Richard D. Leapman2, Peter J. Basser2, William J. Landis3 1Armed Forces Institute of Pathology, Rockville, MD, USA; 2National Institutes of Health, Bethesda, MD, USA; 3Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA. 2127.Relationship between MRI-Derived Bone Volume Fraction and Marrow R2* in the Calcaneus of Patients of Varying Skeletal Status Luna Hilaire1, Felix Wehrli1, Maria Fernandez-Seara1, Bryon Gomberg1, P. J. Snyder1, B. Zemel2 1University of Pennsylvania Medical Center, Philadelphia, PA. USA; 2Children's Hospital of Philadelphia, Philadelphia, PA, USA. Musculoskeletal MRI: Clinical Hall 4 Wednesday: 13:30 - 15:30 2128.Internal Derangement of the Shoulder: Initial Evaluation of the Three Point Dixon Technique Sanjaya Viswamitra1, William B. Morrison2, Mark E. Schweitzer3 1University of Arkansas for Medical Sciences, Little Rock, AR, USA; 2Thomas Jefferson University Hospital, Philadelphia, PA, USA; 3Thomas Jefferson University, Philadelphia, PA, USA. 2129.Diagnostic Axial MRI of Rotator Cuff Injuries Kirk Shane Russell1, J.Antoni Parellada1, John A. Carrino1, Mark E. Schweitzer1 1Thomas Jefferson University, Philadelphia, PA, USA. 2130.MR of Ulnar Variance Kush Singh1, Mark E. Schweitzer1, Larry Parker1 1Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA, USA. 2131.Real-Time MRI of Joint Movement with TrueFISP Harald H. Quick1, Mark E. Ladd1, Matthias Hövel1, Silke Bosk1, Jörg F. Debatin1, Gerhard Laub2, Tobias Schröder1 1University Hospital Essen, Essen, Germany; 2Siemens Medical Systems, Chicago, IL, USA. 2132.MR Imaging of the Loaded Normal and ACL Deficient Knee Joint Saara Totterman1, Karen Boyd1, Jeffrey Houck1, Jose Tamez-Pena1, Arthur Salo1, Wingchi Edmund Kwok1, Amy Lerner1 1University of Rochester, Rochester, NY, USA. 2133.Magnetic Resonance Imaging of the Multiple-Ligament Injured Knee Marc Weinstein1, Hollis Potter1 1Hospital for Special Surgery, New York, NY, USA. 2134.Congenital Anomalies in the Hand: Preoperative Evaluation with MR Imaging and MR Angiography Kazuhiro Ichioka1, Hisao Tonami2, Munetaka Matoba2, Itaru Yamamoto2, Naotaka Ishikura2, Shigehiko Kawakami2 1Kahoku Japan; 2Kanazawa Medical University, Ishikawa, Japan. Japan; 2135.Malignant vs. Benign Soft Tissue Tumors by Decoupled 31P MR Spectroscopy In Vivo Azuma Hashimoto1, Keiko Imamura1, Hisaya Nakajima1, Masayuki Takagi1, Yasuo Nakajima1 1St. Marianna University, School of Medicine, Kawasaki, Japan. 2136.Non-Invasive Approaches for Monitoring the Clinical Chronobiology and Pathology of Acute Infection Diseases by Magnetic Resonance Jesus Ruiz-Cabello1, I. Rodriguez1, R. Perez de Alejo1, Santisteban C.1, M. Cortijo1 1Universidad Complutense de Madrid, Madrid, Spain. 2137.Necrotic Tissue In Pedal Infection: Evaluation by MRI And Its Limitations In The Diagnosis of Abscesses and Osteomyelitis Hans Ledermann1, William Morrison1, Mark Schweitzer1 1Thomas Jefferson University, Philadelphia, PA, USA. 2138.Assessment and Minimization of Susceptibility Artifacts from Different Surgical Talus Screws Rudolf Stollberger1, Franz Seibert1, Johann Raith1, Franz Ebner1 1University of Graz, Graz, Austria. 2139.Altered Vasodilatory Capacity in Arterial Hypertension and its Dependence on the Body Mass as Detected by BOLD-MRI Matthias G Friedrich1, Jeanette Schulz-Menger1, Thoralf Niendorf2, Rainer Dietz1 1Franz-Volhard-Klinik, Charite, Berlin, Germany; 3GE Medical Systems, Leipzig, Germany. 2140.Effects of Iodinated Contrast and Field Strength on Gadolinium Enhancement: Implications for Direct MR Arthrography Douglas D. Montgomery1, William B. Morrison1, Mark Schweitzer1, Dominik Weishaupt2, Lawrence Dougherty1 1Thomas Jefferson University Hospital, Philadelphia, PA, USA; 2University Hospital, Zurich, Switzerland. BASIC SCIENCE FOCUS SESSION (WITH POSTERS) Intraoperative and Miscellaneous Interventional MRI Forth Thursday: 13:30 - 15:30 Chairs: Charles L. Truwit Jens-Peter Schneider 13:30 2141.A Versatile Optical Neuronavigator System for Intraoperative MRI John Koivukangas1, Sanna Kristiina Yrjänä1, Jani Katisko1, Veijo Ukkola1, Juho Tuominen1, Timo Kumpulainen1, Esa Heikkinen1, Eero Ilkko2, Eila Sonkajärvi2, Jaakko Heikkilä1, Mika Ylihautala3, Erkki Vahala3 1Oulu Clinic for Neurosurgery and Neurosurgical Research Unit, Oulu, Finland; 2Oulu University Hospital, Oulu, Finland; 3Marconi Medical Systems Finland, Vantaa, Finland, 13:40 2142.Functional Neuronavigation using an Interventional Magnetic Resonance Imaging (iMRI) System Claudia Dannenberg1, Harald Busse1, Martin Bublat2, Arno Schmitgen2, Christos Trantakis1, Thomas Kahn1 1University Clinic, Leipzig, Germany; 2GMD National Research Center for Information Technology, St. Augustin, Germany. 13:50 2143.Near Real-time MR-guided Stereotactic Procedure Performed at 1.5T Haiying Liu1, Walter A. Hall1, Charles L Truwit1 1University of Minnesota, Minneapolis, MN, USA. 14:00 2144.Using Multiple-Slice CSI to Guide Neurosurgeries Haiying Liu1, Walter A. Hall1, Charles L Truwit1 1University of Minnesota, Minneapolis, MN, USA. 14:10 2145.Extent of High-Grade Glioma Resection for Interventional MRI-Guided Surgery vs. Frameless Neuronavigation-Guided Surgery Chris Lycette1, Gregory J. Rubino1, Julie Byrd1, Keyvan Farahani1, Pablo Villablanca1, Barbara Van De Weile1 1University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA. 14:20 2146.MR Guided Percutaneous Cryotherapy of the Facet Joint Syndrome - Clinical Results with up to Two Years of Follow Up J.F. Roy1, W. Vogt2, G. Ahlbäumer2, P. Montminy1, C. Moisan1 1iMRI unit, Centre hospitalier universitaire de Québec, Québec City, Québec Canada; 2Klinik Gut, St. Moritz, Switzerland. 14:30 2147.Cryoablation in Brain - In Vivo Investigation on Sheep Brain W. Gründer1, A. Goldammer1, H. Barthel1, R. Schober1, T. Straube1, H.-E. Vitzthum1 1University Leipzig, Leipzig, Germany. 14:40 2148.MR Imaging with a Biopsy Needle Ananda Kumar1, Ergin Atalar1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA. 14:50 2149.Heating of Linear Conductive Structures in Interventional MRI Arnulf Oppelt1, Ioannis Delakis2, Wolfgang R. Nitz1 1Siemens AG, Erlangen, Germany; 2University of London, Imperial College of Science, London, UK. 15:00 2150.Efficacy of Registration and Subtraction for Fat-Suppression at 0.5 T for Image-Guided Breast Procedures M. Hirose1, D. F. Kacher1, D. N. Smith1, F. A. Jolesz1 1Brigham and Women's Hospital, Boston, MA, USA. 15:10 2151.Endoscopic MR Imaging in Suspected Esophageal Cancer Umakant Dave1, Andreanna Williams2, David John Gilderdale2, David James Larkman2, David N. Harris2, Simon D. Taylor-Robinson3, Nandita DeSouza2 1Imperial College of Science, Technology and Medicine, University of London, Hammersmith Hospital, London, England, UK; 2Hammersmith Hospital, London, England, UK; 3Imperial College School of Medicine, St Mary's Hospital, London, England, UK. 15:20 2152.Conductivity and Permittivity Changes in Human Calf Tissue Subjected to Temperature Cycling Jeffrey Hand1, Alan Preece2, Yvonne Johnson2, Andrea Williams3, Ian Young3 1Hammersmith Hospitals NHS Trust and Imperial College School of Medicine, Hammersmith Hospital, London, UK; 2Bristol Oncology Centre, Bristol, UK; 3Imperial College School of Medicine, Hammersmith Hospital, London, UK. Intraoperative MR Imaging Hall 4 Wednesday: 13:30 - 15:30 2153.An Asleep Awake Asleep Anesthetic Technique for Intraoperative Language Mapping in the Fringe Fields during Interventional Magnetic Resonance Imaging Guided Neurosurgery Barbara Margaret Van de Wiele1, Eduardo Rubinstein1, Gregory Rubino1 1UCLA School of Medicine, Los Angeles, CA, USA. 2154.Infection Control in a Multi-Use iMR-OR Suite Gregory J Rubino1, Julie Byrd1, Dianne V. Moya1, Yolanda M. Harris1, Maryann Burns1, Barbara Van de Wiele1 1University of California, Los Angeles, Los Angeles, CA, USA. 2155.The Synergistic Effect of Paramagnetic Contrast Agents and Absorbable Hemostatic Agents on 1/T1 of Blood In Vitro: Implications for MRI Marga Spiller1, Michael Tenner1, W. Couldwell1 1New York Medical College, Valhalla, NY, USA. 2156.Considerations about MR-guided Neurosurgery of Patients in Semi-sitting Position Timo Schirmer1, Christos Trantakis2, Klaus Killus2, Dominik Fritzsch2, Harald Busse2 1GE Medical Systems, Munich, Germany; 2University Leipzig, Leipzig, Germany. 2157.Assessment of New Rotating Surgical Table and Head Holder used for iMR-Guided Neurosurgery Gregory J. Rubino1, Chris Lycette1, Ladan Hadjiaghai1, Pablo Villablanca1, Jocelyn Villareal1, Barbara Van De Wiele1 1University of California, Los Angeles, Los Angeles, CA, USA. 2158.Intra-Operative Image Display and Analysis in MRI-Guided Neurosurgery Keyvan Farahani1, Gregory J. Rubino1, Daniel J. Valentino1, Osman Ratib1, Pablo Villablanca1 1University of California, Los Angeles, Los Angeles, CA, USA. 2159.Use of Intraoperative MRI for Treatment of Pediatric Neuropathology Stephen G Hushek1, Lori Russell2, Neil Hoerter2, Robert Moser2, Christopher B Shields3, Todd W Vitaz3, Thomas M Moriarty3 1Norton HealthCare, Louisville, KY USA; 2Norton Hospital, Louisville, KY, USA; 3University of Louisville, School of Medicine, Louisville, KY, USA. 2160.Inta-Operative Magnetic Resonance Imaging (iMR)-Guided Meningioma Resection Gregory J. Rubino1, Julie Byrd1, Dianne Moya1, Pablo Villablanca1, Yolanda Harris1, Barbara Van De Weile1 1University of California, Los Angeles, Los Angeles, CA, USA. 2161.Changing Patterns in Neurosurgical MRI Over a Three Year Period William Guerin Bradley1, Dar-Yeong Chen1, Ivar Szper1, David Lampman1 1Long Beach Memorial MRI Center, Long Beach, CA, USA. Intervention: Vascular and Device Tracking and Visualization Hall 4 Wednesday: 13:30 - 15:30 2162.Real-Time Incremental Difference Reconstruction for Visualization and Tracking of Switchable Catheters Holger Eggers1, Steffen Weiss1, Tobias Schaeffter1, Peter Boesiger2 1Philips Research, Hamburg, Germany; 2Swiss Federal Institute of Technology Zurich and University of Zurich, Zurich, Switzerland. 2163.Development of an MR System Controlled Light Source for Automated Optical Detuning Eddy Y. Wong1, Jeffrey L. Duerk2, Jonathan S. Lewin2, Michael Wendt3 1Case Western Reserve University, Cleveland, OH, USA; 2Case Western Reserve University / University Hospitals of Cleveland, Cleveland, OH, USA; 3Siemens Medical Systems, Iselin, NJ, USA. 2164.Optical Detuning of Parallel-Resonance Circuits in High Field Systems: Initial Experiences Eddy Y. Wong1, Jeffrey L. Duerk2, Kestutis J. Barkauskas1, Jonathan S. Lewin2, Michael Wendt3 1Case Western Reserve University, Cleveland, OH, USA; 2Case Western Reserve University / University Hospitals of Cleveland, Cleveland, OH, USA; 3Siemens Medical Systems, Iselin, NJ, USA. 2165.Fast Catheter Profiling by Controlled Aliasing Lasse Jyrkinen1, Seppo Taivalkoski1, Mika Petri Ylihautala2, Lasse Haataja1, Roberto Blanco Sequeiros1, Rauli Klemola1, Risto Ojala1, Osmo Tervonen1, Olli Silven1 1University of Oulu & Oulu University Hospital, Oulu, Finland; 2Marconi Medical Systems Finland, Vantaa, Finland. 2166.A Technique for Active Visualisation of Needles in MR Guided Procedures David J Gilderdale1, David J Larkman1, Nandita M deSouza1, Joseph V Hajnal1 1Imperial College, School of Medicine, Hammersmith Hospital, London, UK. 2167.A Preliminary Study of a Loop-less Dipole Structure Incorporating a Standard MR Needle. David J Gilderdale1, David J Larkman1, Nandita M deSouza1, Joseph V Hajnal1 1Imperial College, School of Medicine, Hammersmith Hospital, London, UK. 2168.Interventional MRA: Simultaneous Real-time Display of Actively Visualized Catheters and Vascular Morphology with TrueFISP Harald H. Quick1, Dirk Hornscheidt2, Hilmar Kühl1, Silke Bosk1, Jörg F. Debatin1, Mark E. Ladd1 1University Hospital Essen, Essen, Germany; 2Somatex Medical Devices, Berlin, Germany. 2169.Real-Time Imaging and Active Device Tracking for Catheter-Based MRI J. M. Santos1, G. C. Scott1, John M. Pauly1 1Stanford University, Stanford, CA, USA. 2170.Interstitial RF Coil Incorporating Multiple Micro-Catheters Norman Konyer1, Nancy Lobaugh2, Gal Sela1, R. Raghavan3, G. Mills3, M. Brady3, R. Viswanathan3, W. K. Sootsman3, Michael Bronskill1 1Sunnybrook & Women's College Health Sciences Centre, Toronto, Ontario, Canada; 2University of Toronto, Toronto, Ontario, Canada; 3Image-Guided Neurologics, Melbourne, FL, USA. 2171.Micro Imaging with an Active MRI Stent (aMRIs) to Realize Qualitativly Restenosis Diagnosis inside the Stent. Rainer Wetzler1, Martin Busch2, Andreas Melzer3 1Simag GmbH, Berlin, Germany; 2Witten Heven, Germany; 3University Witten/Herdecke, Mülheim/Ruhr, Germany, 2172.2D Projection Magnetic Resonance DSA for MR-guided Intravascular Procedures Klaus U Wentz1, Markus Pfyffer1, Hendrik Lohr1, Johannes M Froehlich1, Constantin von Weymarn1, Scheidegger Markus2, Zollikofer L Christoph1 1Kantonsspital Winterthur, Winterthur, Switzerland; 2Philips Medical Systems, Moosseedorf, Switzerland. 2173.Contrast-Enhanced MR Fluoroscopy: Simultaneous Angiography and Passive Tracking of Devices Clemens Bos1, Chris J.G. Bakker2, Lambertus W. Bartels1, Remko Van Der Weide1, Hanns-Joachim Weinmann3, Max A. Viergever1 1Image Sciences Institute, AZU, Utrecht, The Netherlands; 2University Medical Center Utrecht, Utrecht, The Netherlands; 3Schering Contrast Media Research Laboratories, Berlin, Germany. 2174.In Vivo Validation of Injection Parameters for Intraarterial Gadolinium-enhanced MR Angiography Reed A. Omary1, Kevin P. Henseler2, Orhan Unal2, Howard B. Chrisman1, Scott A. Resnick1, Robert K. Ryu1, Mark B. Saker1, Albert A. Nemcek Jr.1, Robert L. Vogelzang1, Richard Frayne3, Charles M. Strother2, Thomas M. Grist2 1Northwestern University Medical School, Chicago, IL, USA; 2University of Wisconsin-Madison, Madison, WI, USA; 3University of Calgary, Calgary, Alberta, Canada. 2175.Comparison of Intraarterial and Intravenous Gadolinium-enhanced MR Angiography for the Detection of Renal Artery Stenosis Reed A. Omary1, Kevin P. Henseler2, Orhan Unal2, Howard B. Chrisman1, Scott A. Resnick1, Robert K. Ryu1, Mark B. Saker1, Lawrence J. Maciolek2, Charles M. Strother2, J. Paul Finn1, Debiao Li1, Thomas M. Grist2 1Northwestern University Medical School, Chicago, IL, USA; 2University of Wisconsin-Madison, Madison, WI, USA. 2176.Contrast Enhancement at Long Duration and Multiple Coronary MR Angiography Sessions with Intracoronary Infusion of Gd-DTPA Elena Karp1, Nikolaos V. Tsekos1, Pamela K. Woodard1, Yun Gao1, Robert J. Gropler1 1Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA. 2177.Catheter Tracking for MR Guided Selective Procedures Using Real Time Projection Contrast Enhanced MRA: First In Vivo Results in a Patient. R. Strecker1, G. G. Paul2, K. Scheffler1, M. Hering1, J. Laubenberger1, J. Hennig1 1University Hospital, Freiburg, Germany; 2University Hospital, Bonn, Germany. 2178.Intra-Arterial CO2 –Contrast-Enhanced MR Angiography in Interventional MRI: In Vivo Feasibility Study to Provide Road Maps for Catheterization and Comparison of FGRE, Spiral, FGRE-ET, and SSFSE Sequences Yi-Xiang J Wang1, Franck Lethimonnier2, Peter Mt Pattynama1, Robert Maes3, Gabriel P Krestin1 1Erasmus University Medical Center, Rotterdam, The Netherlands; 2GE Medical System, Buc, France; 3Nymegen, Netherlands. 2179.MR-Compatible Intravascular Pressure Measurement: The Annupres Sensor Maurits K. Konings1, Lambertus W. Bartels1, Chris J.G. Bakker1 1University Medical Center Utrecht, Utrecht, The Netherlands. Interventional MR Imaging: Miscellaneous Hall 4 Wednesday: 13:30 - 15:30 2180.Operator Exposure to Acoustic Noise in Interventional MRI A Moelker1, MW Vogel1, M Ouhlous1, F Lethimonnier2, PMT Pattynama1 1University Hospital Rotterdam, Rotterdam, the Netherlands; 2GE Medical Systems, France. 2181.Percutaneous MRI-Guided Discography Roberto Blanco Sequeiros1, Rauli Klemola1, Risto Ojala1, Lasse Jyrkinen1, Osmo Tervonen1 1Oulu University Hospital, Oulu, Finland. 2182.MR-Guided Bone Biopsy: A New Guiding Method Risto Ojala1, Roberto Blanco Sequeiros1, Erkki Vahala2, Rauli Klemola1, Lasse Jyrkinen1, Osmo Tervonen1 1University Hospital of Oulu, Oulu, Finland; 2Picker Nordstar, Inc., Vantaa, Finland. 2183.Registration of Optical Navigator in Staged Musculoskeletal Procedures Erkki Vahala1, Riitta Parkkola2, Risto Ojala3, Teuvo Vaara1, Mika Ylihautala1, Gösta Ehnholm1 1Marconi Medical Systems Finland, Inc., Vantaa, Finland; 2University of Turku, Turku, Finland; 3University Hospital of Oulu, Oulu, Finland; 2184.A Hybrid System For MRI Guided Biopsy Cameron Anthony Piron1, Donald Plewes2, Rene Shumak2 1University of Toronto, Toronto, ON, Canada; 2University of Toronto, Sunnybrook & WCHSC, Toronto, ON, Canada. 2185.MR-Guided Implantation of Brachytherapy Catheters for Treatment of Recurrences of Head and Neck Tumors Thomas Schulz1, Jens Peter Schneider1, Annette Weber1, Annette Köhler-Brock1, Friedrich Bootz1, Frank Schmidt1, Thomas Kahn1 1University of Leipzig, Leipzig, Germany. 2186.Saline Injection In Ex Vivo Liver: Monitoring With Fast Gradient Echo Sequences At 0.2 T Sherif Gamal Nour1, Jonathan S. Lewin1, Jeffrey L. Duerk1 1University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA. 2187.Real Time MRI Guided Drug Delivery Jonathan M. Sorger1, Michael A. Guttman2, Ralf Wassmuth2, Elliot McVeigh2 1Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2National Institutes of Health, Bethesda, MD, USA. 2188.Investigation of Electron Trajectories of an X-Ray Tube in a Magnetic Field Z. Wen1, Rebecca Fahrig1, Norbert J. Pelc1 1Stanford University, Stanford, CA, USA. Temperature MR Imaging Hall 4 Tuesday: 13:30 - 15:30 2189.Feasibility of Internally-Referenced Temperature Imaging using Metabolite Signals Kagayaki Kuroda1, Robert V. Mulkern2, Koichi Oshio2, Nathan McDannold2, Kullervo Hynynen2, Toshiharu Nakai3, Tomohisa Okada4, Akira Matsumura5, Kiyoyuki Yanaka5, Ferenc Jolesz2 1Tokai University, Hiratsuka, Kanagawa, Institute of Biomedical Research and Innovation, Kobe, Hyogo, Japan; 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; 3AIST, Ikeda, Osaka, Institute of Biomedical Research and Innovation, Kobe, Hyogo, Japan; 4Fukui Medical University, Yoshidagun, Fukui, Japan; 5University of Tsukuba, Tsukuba, Ibaraki, Japan. 2190.Is Absolute Temperature Measurement in the Breast with H1 Spectroscopic Imaging Feasible? Nathan J. McDannold1, Robert V. Mulkern2, Kagayaki Kuroda3, Kullervo H. Hynynen4 1Harvard Medical School and Tufts University, Boston, MA, USA; 2The Children's Hospital, Harvard Medical School, Boston, MA, USA; 3Tokai University, Tokai, Japan; 4Harvard Medical School, Boston, MA, USA. 2191.Temperature Monitoring with MRI with Multiple Phase-Encode and Slice Select Dimensions During Focused Ultrasound Surgery Nathan J. McDannold1, Lawrence Patrick Panych2, Lei Zhao2, Ferenc A. Jolesz2, Kullervo H. Hynynen2 1Harvard University and Tufts University, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USA. 2192.The Effects of Local Temperature Increase on the MR Phase Image Obtained with Electrical Current Injection Soo Yeol Lee1, Hyun Soo Khang1, Min Hyoung Cho1, Eung Je Woo1, Chi Woong Mun2 1Kyung Hee University, Yongin, Kyungki, Korea; 2Inje University, Korea. 2193.Real-Time Motion Correction in MR-Controlled Hyperthermia Jacco De Zwart1, Frederic Vimeux2, Jean Palussiere2, Rares Salomir2, Bruno Quesson2, Christophe Delalande2, Chrit Moonen3 1CNRS/Universite Victor Segalen, Dieren, Netherlands; 2CNRS/Univ de Bordeaux II, Bordeaux, France; 3Université Victor Segalen Bordeaux 2, Bordeaux, France. 2194.Temperature Measurement Using the 129Xe Chemical Shift Arvind Venkatesh1, Daniel F. Kacher2, Kagayaki Kuroda3, Dilip Balamore4, Ferenc A. Jolesz2, Mitchell S Albert2 1Boston University, Boston, MA, USA; 2Brigham and Women's Hospital, Boston, MA, USA; 3Tokai University, Hiratsuka, Japan; 4Nassau Community College, Garden City, NY, USA. 2195.Use of Fast-Spin-Echo MRI for MR Thermometry Mika Vogel1, Franck Lethimonnier2, Peter Pattynama1, Patrick Leroux2 1Erasmus University Rotterdam, Rotterdam, Netherlands; 2GE Medical Systems, Buc, France. 2196.PRF Shift Thermometry at 0.2T: A New Background Phase Variation Suppression Scheme and Its Impact On Thermal Lesion Fidelity Kestutis J. Barkauskas1, Michael Wendt1, Jonathan S. Lewin2, Jeffrey L. Duerk2 1Case Western Reserve University, Cleveland, OH, USA; 2Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, USA. 2197.Stabilized In Vivo Temperature Mapping on an Open 0.3-T MRI System Tetsuhiko Takahashi1, K. Komura1, M. Dohi2, J. Harada2 1Hitachi Medical Corporation, Kashiwa, Chiba Japan; 2The Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan. 2198.Significant Precision Improvement for Temperature Mapping Lin Li1, Erik Shapiro1, John Leigh1 1University of Pennsylvania, Philadelphia, PA, USA. 2199.Estimating Tissue Conductivity by MR Thermometry and Focused Ultrasound Heating Hai-Ling Margaret Cheng1, Donald Plewes2 1University of Toronto, Toronto, ON, Canada; 2University of Toronto, Sunnybrook & WCHSC, Toronto, ON, Canada, 2200.In Vivo Temperature Mapping of Frozen Tissue Using R2* Janaka Wansapura1, Bruce L. Daniel1, Kim Butts1 1Stanford University, Stanford, CA, USA. Thermal Therapies Hall 4 Tuesday: 13:30 - 15:30 2201.Performance of a 4-Element Experimental RF-Hyperthermia Applicator Studied by MR-Thermometry Werner Hoffmann1, Frank Seifert1, Ralph Noeske1, Waldemar Wlodarczyk2, Herbert Rinneberg1 1Physikalisch-Technische Bundesanstalt, Berlin, Germany; 2Charite Medical School - Campus Virchow-Klinikum, Berlin, Germany. 2202.MR-based Temperature Monitoring for Radiofrequency Ablation with Expandable Needle Electrode Shigeo Okuda1, Kagayaki Kuroda2, Koichi Oshio3, Hirokazu Fujiwara1, Tadanobu Kurata1, Masahiro Jinzaki1, Hiroshi Shinmoto1, Akihiro Tanimoto1, Yutaka Imai1, Yuji Yuasa1, Sachio Kuribayashi1 1Keio University, Tokyo, Japan; 2Tokai University, Tokai, Japan; 3Harvard University, Boston, MA, USA. 2203.Combined Thoracoscope-Assisted MR-Guided Microwave Ablation of Liver Tumors Yoshimasa Kurumi1, Tohru Tani1, Shigeyuki Naka1, Shigehiro Morikawa1, Toshiro Inubushi1, Viswanathan Seshan2 1Shiga University of Medical Science, Ohtsu, Shiga, Japan; 2G.E.Yokogawa Medical Systems, Hino, Tokyo, Japan. 2204.Clinical Experiences with MR-Guided Microwave Ablation for Liver Tumors. Yoshimasa Kurumi1, Tohru Tani1, Shigeyuki Naka1, Shigehiro Morikawa1, Toshiro Inubushi1, Viswanathan Seshan2 1University of Medical Science, Ohtsu, Shiga, Japan; 2G.E. Yokogawa Medical Systems, Hino, Tokyo, Japan. 2205.MR Guided Laser Thermal Ablation of Renal and Adrenal Tumours Elizabeth A. Dick1, Rita Joarder1, J Vale1, Wladyslaw Gedroyc1 1St Marys Hospital, London, UK. 2206.Study of In Vivo Laser Ablated Tissue Damage using MA Thermometry Lili Chen1, Janaka Wansapura1, Gary Heit1, Kim Butts1 1Stanford University, Stanford, CA, USA. 2207.Optimization of the LITT Protocol for Hyperthermia Treatment of Prostate by Means of Simulations and MR-Thermometry Kamil A. Il'yasov1, Gregor Bruggmoser1, Rudolf Steberl1, Valerij G. Kiselev1, Jürgen Hennig1 1Freiburg University Hospital, Freiburg, Germany. 2208.MRI Monitoring of Focused Ultrasound Surgery in Tumors with Multi-Slice Echo-Planar Imaging in Rabbits Nathan J. McDannold1, Kullervo H. Hynynen2, Ferenc A. Jolesz2 1Harvard Medical School and Tufts University, Boston, MA, USA; 2Harvard Medical School, Boston, MA, USA. 2209.MR Guided Interstitial Ultrasound Ablation of Experimental Brain Tumors John D. Hazle1, Roger E. Price1, Don F. Schomer1, R. Jason Stafford1, Lars E. Olsson1, Chris J. Diederich2, P. Dan Tyreus2 1University of Texas M. D. Anderson Cancer Center, Houston, TX, USA; 2University of California, San Francisco, San Francisco, CA, USA. 2210.Diffusion-Weighted MRI after Cryosurgery of the In Vivo Canine Prostate Kim Butts1, Bruce L. Daniel1, Janaka Wansapura1, Lili Chen1, Stephan Maier2, Charles Dumoulin3, Ronald Dean Watkins3 1Stanford University, Stanford, CA, USA; 2Harvard University, Brigham and Women's Hospital, Boston, MA, USA; 3G. E. Corporate R & D Center, Niskayuna, NY, USA. 2211.MR Guided Cryosurgery of the Sacroiliac Joint: Technique and Early Clinical Results J.F. Roy1, M. Hess2, C. Moisan1 1Centre hospitalier universitaire de Québec, Québec City, Québec Canada; 2Orthopedic Hospital Munich-Harlaching, Klinik Müchen-Harlaching, Munich, Germany. 2212.Percutaneous Renal Cryoablation for Renal tumors using imri guidance Patrick Ellison Sewell Jr1, W. Bruce Shingleton1 1University of Mississippi Medical Center, Jackson, MS, USA. 2213.Quantitative Improvement to Image Contrast when Using MnDPDP during MR Guided Percutaneous Cryosurgeries of the Liver A.S. Traore1, M.-J. Godbout1, D. Serre1, G. Dionne1, M. Dufour1, C. Moisan1 1Centre hospitalier universitaire de Québec, Québec City, Canada. Molecular MRS and MRI of Cancer Hall 4 Monday: 14:00 - 16:00 2214.Ex vivo and In Vivo Evaluation of Tumor Burden in Mouse Lung using MRI: Assessment of Anti-Metastatic Drug Properties Stasia A. Anderson1, Randall K. Rader1, Kristen Shannon1, Ben Zweifel1, Janet O'Neal1, William F. Westlin1, Alane Koki1, Jaime L. Masferrer1, John J. Kotyk1 1Pharmacia Corporation, St. Louis, MO, USA. 2215.Evaluation of Breast Cancer Cell Invasion with the 'Metabolic Boyden Chamber' Ellen Ackerstaff1, Dmitri Artemov1, Robert Gillies2, Zaver Bhujwalla1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2University of Arizona, Arizona Health Science Center, Tucson, AZ, USA. 2216.ras Transformation and Metabolism: An MRS Investigation M. Beloueche1, L. E. Jackson1, M. O. Leach1, S. M. Ronen1 1Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK. 2217.Ex Vivo and In Vivo Evaluations of Osteolytic Metastases in Mice: Comparison of MRI, Bone Mineral Density, and Fluorescence Microscopy John J. Kotyk1, John F. Harms2, Steve L. Settle1, Randall K. Rader1, Gabriel Mbalaviele1, David W. Griggs1, William F. Westlin1, Danny R. Welch2 1Pharmacia Corporation, St. Louis, MO, USA; 2Pennsylvania State University College of Medicine, Hershey, PA, USA. 2218.Molecular Imaging Using Functional Genomics: Spatial and Temporal Resolution of Gene Expression Profiles Using Contrast Enhanced MRI Yi-Shan Yang1, Samira Guccione1, King C. Li1, Mark Bednarski1 1Stanford University, Stanford, CA, USA. 2219.Correlation of Water Diffusion and Cell Growth in a 3D Perfused Cell Culture System Theodore P. Trouard1, Joseph L. Divijak1, Norbert W. Lutz1, Kathy A. McGovern1 1University of Arizona, Tucson, AZ, USA. 2220.MRI and PET Characterization of Abdominal Tumors in a Hamster Model of Colorectal Cancer Joel R. Garbow1, Jason S. Lewis1, Judith M. Connett1, Thomas L. Buettner1, Michael J. Welch1 1Washington University, St. Louis, MO, USA. 2221.Performance of Potential Tumor Seeking MR Contrast Agent Mn-porphyrin (HOP-8P) in Mice Model Yasuo Takehara1, Harumi Sakahara1, Hatsuko Masunaga1, Satoshi Isogai1, Nami Kodaira1, Masahiro Sugiyama1, Hiroyasu Takeda1, Tsuneo Saga2, Susumu Nakajima3, Isao Sakata4 1Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; 2Kyoto University Graduate School of Medicine, Kyoto, Japan; 3Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan; 4Photochemical Co. Ltd, Okayama, Japan. 2222.MR Imaging As a Tool to Monitor Prostate Tumor Growth in Mice with Mutant p53 Gene. Pal Kiss1, Laszlo Lenard1, Tamas Simor1, John R. Forder1, Roycelynn Mentor-Marcel1, Ada Elgavish1, Gabriel A. Elgavish1 1University of Alabama at Birmingham, Birmingham, AL, USA. 2223.Assessment of Tumor Viability by Diffusion-weighted MRI E. Edmund Kim1, X. Joe Zhou1, Graeme McKinnon2, Haesun Choi1, Shreyaskumar R. Patel1 1University of Texas M.D. Anderson Cancer Center, Houston, TX, USA; 2G. E. Medical Systems, Milwaukee, WI, USA. Lipid and Choline in Cancer Hall 4 Monday: 14:00 - 16:00 2224.In Vivo 1H and 31P NMR Study of Hepatic Apoptosis in Anti-Fas Treated Mice Michael Skalski1, Lesley May Foley1, Anne Baggley1, Melissa Yau1, Manfred Brauer1 1University of Guelph, Guelph, Ontario, Canada. 2225.Malignant Cells Influence the Phospholipid Phenotype of Human Vascular Endothelial Cells Noriko Mori1, Kshama Natarajan1, Vadappuram P. Chacko1, Dmitri Artemov1, Zaver M. Bhujwalla1 1Johns Hopkins University, Baltimore, MD, USA. 2226.31P MRS of Thymoma Cell Extracts Indicates Increased Phospholipase Activity following Dexamethasone Treatment, in Correlation with Apoptotic Parameters Margaret E. Tome1, Margaret M. Briehl1, Norbert W. Lutz1 1University of Arizona, Tucson, AZ, USA. 2227.Effects of Apoptosis on the Lipid Metabolism in KB Tumor Cells Studied by One- and Two-dimensional NMR Spectroscopy Touraj Shokati1, Joern Engelmann1, Wieland Willker1, Dieter Leibfritz1 1University of Bremen, Bremen, Germany. 2228.1H and 31P Nuclear Magnetic Resonance Spectroscopy Study of Diamide-Induced Apoptosis in Tumors and Isolated Tumor Cells Angele Viola1, Kevin Michael Brindle2 1Faculté de Médecine la Timone, Marseille, Marseille, France; 2University of Cambridge, Cambridge, England, UK, 2229.Imbalance of CDP Pathways and Up-Regulation of Phosphoethanolamine under CENU Treatment in Long Term Cultures of Malignant Melanoma Cells. A 1H-HRMAS MRS Study. Daniel Morvan1, Aicha Demidem, Janine Papon, Jean Claude Madelmont 1INSERM U_484, Clermont-Ferrand, France. 2230.L-Methionine Supplementation Disrupts Sequential Activation of Phospholipases during Tumor Growth in a Murine Model of Malignant Melanoma. A 1H-HRMAS MRS Study. Aicha Demidem1, Daniel Morvan, Janine Papon, Jean Claude Madelmont 1INSERM U_484, Clermont-Ferrand, France, 2231.Impact of Indomethacin on Phospholipid Metabolism in Malignant Human Mammary Epithelial Cells: 1H and 31P NMR Spectroscopic Study of Viable Cells Kristine Glunde1, Ellen Ackerstaff1, Kshama Natarajan1, Dmitri Artemov1, Zaver M. Bhujwalla1 1Johns Hopkins University, Baltimore, MD, USA. Oxygenation, Hypoxia, and pH Studies of Cancer Hall 4 Monday: 14:00 - 16:00 2232.Effect of Carbogen Breathing on a Chemically Induced Hepatocarcinoma Model in Mice Carole D. Thomas1, Evelyne Chenu1, Christine Walzcac1, Marie-Jose Plessis1, Francois Perin1, Andreas Volk1 1Curie Institute - Research, Orsay, France. 2233.Analysis of Human Tumor Xenograft Oxygenation and Correlation to Vascular Density, Viability and Necrosis with Functional MRI at 1.5T Song Lai1, Geon-Ho Jahng1, Jiongjiong Wang1, Lahmer Lynds1, Gail R. Ramsby1, Kevin P. Claffey1, Anshu Agarwal1, Marty Keough1 1University of Connecticut Health Center, Farmington, CT, USA. 2234.Increased Lactate Characterizes Malignant Transformation in Human Prostate Cancer Cells Ellen Ackerstaff1, Beth R. Pflug2, Joel B. Nelson2, Zaver M. Bhujwalla1 1Johns Hopkins University, Baltimore, MD, USA; 2University of Pittsburgh, Shadyside Medical Center, Pittsburgh, PA, USA. 2235.Enhancement of Hyperglycemia-Induced Acidification of Human Melanoma Xenografts by Inhibitors of Respiration an Ion Transport R. Zhou1, S. Pickup1, D. B. Leeper2, Jerry Glickson1 1University of Pennsylvania, Philadelphia, PA, USA; 2Thomas Jefferson University, Philadelphia, PA, USA. 2236.Effect of Insulin on Tumor Oxygenation and Perfusion Bénédicte Jordan1, Vincent Gregoire1, Roger Demeure1, Bernard Gallez1 1Université catholique de Louvain, Brussels, Belgium. 2237.Indirect Detection of Reactive Oxygen Species by 1H NMR: Monitoring of Reduced Form of Nitroxyl Spin Probes Hideto Kuribayashi1, Hideo Utsumi1 1Kyushu University, Fukuoka, Japan. 2238.Heparin-Induced Hemodynamic Alterations: A BOLD Contrast MRI Study Galia Tsarfaty1, Tammar Kushnir1, Rinat Abramovitch1, Miriam Shaharabany2, Rotem Ron2, Judith Horev3, Yacov Itzchak1, Ilan Tsarfaty3 1The Chaim Sheba Medical Center, Tel Hashomer, Israel; 2fBIT Ltd., Ramat-Gan, Israel; 3Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel. Tumor Perfusion and Permeability Hall 4 Monday: 14:00 - 16:00 2239.Simulation of the Effect of Impaired Renal Function on Contrast Enhanced MRI Measurements in Cancer Trevor Ahearn1, Thomas W Redpath1, Roger Staff1 1University of Aberdeen, Aberdeen, Scotland, UK. 2240.Dynamic Contrast Enhanced Liver MRI Using a Motion Tracking Algorithm Michael D. Noseworthy1, Marshall S. Sussman2, Masoom Haider3, Sylvain Baruchel1 1University of Toronto, The Hospital For Sick Children, Toronto, ON, Canada; 2University of Toronto, Sunnybrook Health Science Centre, Toronto, ON, Canada; 3University of Toronto, Princess Margaret Hospital, Toronto, ON, Canada. 2241.B0-Dependence of the CR-Determined Exchange Regime for Equilibrium Transcytolemmal Water Transport: Implications for Bolus-Tracking Studies Charles Springer1, William Rooney1 1Brookhaven National Laboratory, Upton, NY, USA. 2242.A Simple Model to Characterise Blood-Brain Barrier Leakage from T2*-weighed Bolus Tracking MRI Data Paul Stephen Tofts1, G. Johnson2, S. Cha2 1University College London, Institute of Neurology, London, UK; 2New York University School of Medicine, New York, NY, USA. 2243.Assessing Tumor Angiogenessis with Dynamic Susceptibility Contrast fMRI Which Morphologc Correlates Are Relevant? A.P Pathak1, Kathleen (Donahue) Schmainda2, B. D. Ward2, K. J. Rebro2, Scott Rand2 1Marquette University, Milwaukee, WI, USA; 2Medical College of Wisconsin, Milwaukee, WI, USA. 2244.Determination of Vascular Permeability and Extracellular Volume Fraction in Human Breast Cancer Tumors Implanted in SCID Mice Yael Bergknoff1, Raanan Margalit1, Dov Grobgeld1, Hadassa Degani1 1Weizmann Institute of Science, Rehovot, Israel. 2245.Dynamic Contrast-Enhanced MRI: Image Analysis Techniques for Treatment Response Studies Carmel Hayes1, Anwar R Padhani1, Martin O Leach1 1The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, UK. 2246.Identifying Tumor Permeability Heterogeneity with MRI Contrast Agents Michael Aref1, Martin Brechbiel2, Erik Wiener1 1University of Illinois at Urbana-Champaign, Urbana, IL, USA; 2National Institutes of Health, Bethesda, MD, USA. 2247.A Marker of Vascular Tortuosity (Relative Recirculation) in Gliomas: Comparison with Blood Volume and Tumor Grade Andrea Kassner1, Xiaoping Zhu2, Ka-Loh Li2, Alan Jackson2 1Philips Medical Systems, Leeds, England, UK; 2University of Manchester, Manchester, England, UK.; 2248.MR-Derived Cerebral Blood Volume Maps: Issues Regarding Histological Validation and Assessment of Tumor Angiogenesis A.P Pathak1, Kathleen (Donahue) Schmainda2, B. D. Ward3, K. J. Rebro3, Andrew S. Greene2 1Marquette University, Milwaukee, WI, USA; 2Medical College of Wisconsin, and Marquette University, Milwaukee, WI, USA; 3Medical College of Wisconsin, Milwaukee, WI, USA. 2249.Identifying High 'Metastatic Risk' Vascular and Physiological Regions in Solid Tumors Zaver M Bhujwalla1, Dmitri Artemov1, Paloma Ballesteros2, Sebastian Cerdan3, Robert Gillies4, Meiyappan Solaiyappan1 1Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 2UNED, Madrid, Spain; 3Inst Investigaciones Biomedicas CSIC, Madrid, Spain; 4University of Arizona, Arizona Health Science Center, Tucson, AZ, USA 2250.Dynamic Contrast-Enhanced Subtraction and Delayed MRI of Gastric Tumors: Radiologic-Pathologic Correlation Gin Chung Liu1, Chien Kuo Wang1, Yu Ting Kuo1 1Kaohsiung Medical University, Kaohsiung, Taiwan, ROC. 2251.CR Bolus-Tracking Pharmacokinetic Parameters: The Effects of Equilibrium Transcytolemmal Water Exchange Thomas E. Yankeelov1, William Rooney1, Charles Springer,Jr.1 1Brookhaven National Laboratory, State University of New York, Upton, NY, USA. 2252.Multi-section Dynamic MR Imaging Covering Whole Volume of the Prostate Masayuki Yamaguchi1, Mamoru Niitsu2, Yuji Itai3 1University of Tsukuba Hospital, Tsukuba, Ibaraki Japan; 2Institute of Clinical Medicine, Ibaraki, Japan; 3Tsukuba, Ibaraki, Japan; 2253.A Model for Mapping Angiogenesis using Dynamic Contrast-Enhanced MRI Q.G. de Lussanet1, W.H. Backes1, R. G. H. Beets-Tan1, J. W. Maas1, H. A. Struyker-Boudier1, J. L. Evers1, J. M. A. van Engelshoven1 1University Hospital Maastricht, Maastricht, Netherlands. 2254.Saturation Steady-State Weighting of MRI Intensity: Tracking Instantaneous T1 Changes Jing-Huei Lee1 1Brookhaven National Laboratory, Upton, NY, USA. 2255.Comparison of Propeller, Spiral And Variable Density Spiral Trajectories for Dynamic Contrast Enhanced MRI of Cancer Ergun Ahunbay1, James Pipe2, Jeffrey L. Evelhoch1 1Wayne State University, Harper Hospital, Detroit, MI, USA; 2Barrow Neurological Institute, Phoenix, AZ, USA 2256.H215O PET Validation of Tumor Blood Flow Determined by Double Echo Dynamic Perfusion-Weighted MR Imaging Satoshi Muramoto1, Hidemasa Uematsu1, Norihiro Sadato1, T. Tsuchida1, Hirohiko Kimura1, Tsuyoshi Matsuda2, Yoshiharu Yonekura1, H. Itoh 1Fukui Medical University, Fukui, Japan; 2GE Yokogawa Medical Systems Ltd., Tokyo, Japan. Cancer Treatment: Anti-angiogenesis and Anti-vascular Hall 4 Monday: 14:00 - 16:00 2257.Effect of Dexamethasone Treatment on Dynamic Susceptibility CBV Measurements in a Rat Brain Tumor Model K.M. (Donahue) Schmainda1, A. P. Pathak1, M. Badruddoja1, S. D. Rand1, K. Rebro1, H. G. Krouwer1 1Medical College of Wisconsin, Milwaukee, WI, USA. 2258.Evaluation of the Anti-Vascular Effects of Combretastatin in Rodent Tumours by Dynamic Contrast Enhanced MRI. Ross J Maxwell1, John Wilson1, Gillian M Tozer1 1Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK. 2259.Assessment of Tumour Response to Matrix Metalloproteinases Inhibitors Treatment Using Dynamic Gd-DTPA Enhanced MR Imaging. Nathalie Just1, Carmel Hayes1, Ian J Rowland1, Suzanne Eccles2, Martin O Leach1 1Institute of Cancer Research, The Royal Marsden Hospital, Sutton, England, UK; 2Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, England, UK. 2260.Differential Sensitivity of a Tumor Model to Two Anti-Vascular Drugs Daniel A. Beauregard1, R. Barbara Pedley2, Sally A. Hill3, Kevin M. Brindle1 1University of Cambridge, Cambridge, UK; 2University College London, School of Medicine, London, UK; 3Gray Laboratory Cancer Research Trust, Middlesex, UK. 2261.Contrast Enhanced MRI Perfusion Evaluation of Vascular Response: Results of a Phase I Clinical Trial of Combretastatin A4 Niusha Rafie1, John A. Jesberger2, Jeffrey L. Duerk2, Matthew M. Mendez1, Scott C. Remick2, Jonathan S. Lewin2 1Case Western Reserve University, Cleveland, OH, USA; 2Case Western Reserve University/ University Hospital of Cleveland, Cleveland, OH, USA. 2262.Assessing Perfusion and Capillary Permeability Changes Induced by a VEGF Inhibitor in Human Tumor Xenografts Using Macromolecular MR Imaging Contrast Media Clément Pradel1, Nathalie Siauve1, Charles-André Cuénod1, Frédérique Frouin1, Gaëlle Bruneteau1, Edmond Kahn1, Olivier Clément1, Guy Frija1 1University of Necker, Paris, France. 2263.Changes in Vasculature Detected in a Breast Cancer Model Following Treatment with an Anti-inflammatory Agent Kshama Natarajan1, Dmitri Artemov1, Zaver Bhujwalla1 1Johns Hopkins University, School of Medicine, Baltimore, MD USA. 2264.Cerebral Blood Flow in Rat is Reduced by Antitumor Agent, Arsenic Trioxide(As2O3) J. C. Lin1, R. J. Griffin1, S.-G. Kim1, Michael Garwood1 1University of Minnesota, Minneapolis, MN, USA. 2265.Assessment of The Novel Tumour Vascular Targeting Agent ZD6126 By Non-Invasive Multi-Gradient Echo MRI Simon Robinson1, Dominick McIntyre1, Franklyn Howe1, John R. Griffiths1, David C. Blakey2, John Waterton2 1St. George's Hospital Medical School, London, England, UK; 2AstraZeneca, Macclesfield, Cheshire, UK. 2266.Dynamic Contrast Enhanced Imaging Assessment of the Effects of Antiangiogenic Agent SU5416 in Inflammatory Breast Cancer: Preliminary Results John A. Jesberger1, Niusha Rafie1, Matt Mendez2, Jeffrey L. Duerk2, Scot Remick2, Beth Overmoyer2, Jonathan S. Lewin2 1Case Western Reserve University, Cleveland, OH, USA; 2University Hospitals Of Cleveland, Case Western Reserve University, Cleveland, OH, USA. Tumor Response to Therapy Hall 4 Monday: 14:00 - 16:00 2267.Evaluation of Brain Tumor Response to Therapy with 1H MRS, Diffusion and Perfusion MRI: Correlation between Choline Level and ADC, rCBV Wei Huang1, Patricia Roche1, Alina Tudorica1, Stefan Madajewicz1, Terry M. Button1, H. Li1, J. Manzione1, Clemente Roque1 1State University of New York at Stony Brook, Stony Brook, NY, USA. 2268.Role of Global Lactate and Dynamic Contrast Imaging in Detecting Response of RIF-1 Tumors to Cyclophosphamide Treatment Harish Poptani1, Navin Bansal1, Robert Graham1, David Nelson1, Jerry Glickson1 1University of Pennsylvania, Philadelphia, PA, USA. 2269.Early Prediction of Tumor Response to Therapy Using Diffusion Weighted MRI Yael Mardor1, Thomas Tichler1, Yiftach Roth1, Yael Weiss1, Raanan Berger1, Ami Glicksman1, Rafael Pfeffer1, Roberto Spiegelman1, Jesus Ruiz-Cabello2, Stephan E Maier3, Arie Orenstein1, Jack Cohen1 1Sheba Medical Center, Tel-Hashomer, Israel; 2Universidad Complutense, Madrid, Spain; 3Harvard University, Harvard Medical School, Boston, MA, USA. 2270.Studies of Ifosfamide and Cyclophosphamide using 31P MRS GS Payne1, S Vaidya1, F Kinnaird1, CR Pinkerton1, MO Leach1 1Royal Marsden NHS Trust and Institute of Cancer Research, Sutton, Surrey UK. 2271.Early Assessment by In Vivo 1H-MRS of Tumor Response to Temozolomide in Gliomatosis Cerebri R. Lodi1, V. Clementi1, P. Cortelli2, L. Crinò3, S. Iotti1, B. Barbiroli1 1Università di Bologna, Bologna, Italy; 2Università di Modena, Italy; 3Ospedale Bellaria, Italy. 2272.The Relationship between P-31 Metabolites and Oncolytic Viral Therapy Sensitivity in Human Colorectal Cancer Xenografts Kristen Zakian1, Sandeep Malhotra1, Scarlett Karakash1, Su Xu1, Cornelia Matei1, Yuman Fong1, Jason Koutcher1 1Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2273.Magnetic Resonance Imaging In Vivo - Evaluation of Hepatocellular Carcinomas (HCC) post Gene Therapy (Adenoviral Transfection of Interleukin-12 / B7.1) in Woodchucks Christoph U. Herborn1, Brigitte M. Puetzer1, Jörg F. Debatin1, Stefan G. Ruehm1 1University Hospital Essen, Essen, Germany. 2274.Cryo Destruction of Hepa-1 Multicellular Spheroids: A Diffusion Weighted MRI and MR Spectroscopy Study Catherine Tempel Brami1, Rinat Abramovitch1, Uri Nevo2, Aviv Barzilai3, Yacov Itzchak1, Michal Neeman4, Tammar Kushnir1 1The Chaim Sheba Medical Center, Tel Hashomer, Israel; 2Tel Aviv University, Tel-Aviv, Israel; 3Kaplan Medical Center, Rehovot, Israel; 4Weizmann Institute of Science, Rehovot, Israel. 2275.Chemotherapy Treatment Assessment using Apparent Diffusion Coefficient Maps Liz Moore1, Louis Viviers2, Juliet Britton2, Charlotte Absen3, Martin Leach1, Micheal Brada2 1Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey, UK; 2The Royal Marsden NHS Trust, Sutton, Surrey, UK; 3Atkinson Morley NHS Trust, London, UK. 2276.19F MRS study of the Pharmacokinetics of 5-fluorouracil (5-FU) in the Liver of Patients with Colorectal Cancer and Liver Metastases Yvonne Kamm1, Adrianus Van Den Bergh1, Theo Wagener1, Hanneke Van Laarhoven1, Dennis Klomp1, Arend Heerschap1 1University Medical Centre Nijmegen, Nijmegen, the Netherlands. 2277.Correlation Between the Longitudinal Changes of Tumor Size and the Enhancement Kinetics in Tumors Receiving Gene Therapy M. Y. Su1, J. Wang1, J. A. Taylor1, L. P. Villarreal1, O. Nalcioglu1 1University of California, Irvine, CA, USA. 2278.Monitoring Early Response of Human Breast Cancer Xenografts to Taxotere Chemotherapy via 31P MRS and Diffusion MRI David Morse1, Natarajan Raghunand1, Jean-Philippe Galons1, Robert Gillies1 1University of Arizona, Tucson, AZ, USA. Brain Cancer Hall 4 Wednesday: 13:30 - 15:30 2279.Triple Quantum Filtered 23Na MR Spectroscopy of 9L Glioma in the Presence of Shift Reagent Patrick M. Winter1, Navin Bansal2 1Washington University School of Medicine, St. Louis, MO, USA; 2University of Pennsylvania, Philadelphia, PA, USA. 2280.Classification of Cerebral Infection and Tumour by Linear Discriminant Analysis of Biopsy Spectra Theresa Dzendrowskyj1, Roger Bourne1, Uwe Himmelreich1, Carolyn Mountford1, Tania C. Sorrell1 1University of Sydney, Sydney, NSW, Australia. 2281.Characterization of Intracranial 9L Glioma in Rat Using MR Perfusion and BOLD Imaging at 7T with Carbogen Breathing Hao Lei1, Julia A. O'Hara1, Huagang Hou1, Carmen M. Wilmot1, Harold M. Swartz1, Jeffrey F. Dunn1 1Dartmouth College, Dartmouth Medical School, Hanover, NH, USA. 2282.Novel Cell Labeling Strategy for Magnetic Resonance Microimaging of Brain Tumor Invasion In Vivo. Kenneth Bahk1, P N Venkatasubramanian1, A M Wyrwicz1 1Northwestern University, Evanston, IL, USA. 2283.Improved Analysis of 1H-MR Spectra in the Presence of Mobile Lipids: Impact on Grading of Malignant Gliomas Dorothee P. Auer1, Christoff Gössl1, Timo Schirmer2, Michael Czisch1 1Max Planck Institute of Psychiatry, Munich, Germany; 2GE Medical Systems, Buc, France. 2284.Differentiating Types of Human Brain Tumours by MRS. A Comparison of Pre-processing Methods and Echo Times A. Rosemary Tate1, John R. Griffiths1, Franklyn A. Howe1, Jesus Pujol2, Carles Arús3 1St. George's Hospital Medical School, London, UK; 2Centre Diagnostic Pedralbes, Barcelona, Spain; 3Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain. 2285.Diffusion Tensor Imaging at 3 Tesla: A Potential Tool for Assessing Occult White Matter Tract Invasion? Stephen J. Price1, Jonathan H. Gillard1, Neil G. Burnet1, Dylan Pritchard2, Nikos Papadakis2, Kay Martin2, T. Adrian Carpenter2, Tim Donovan2, John D. Pickard1 1Addenbrooke's Hospital, Cambridge, UK; 2University of Cambridge, Cambridge, UK. 2286.Intraindividual Comparison of Contrast Enhancement in Brain Tumors: A Blinded Reader Comparison of a Standard Gd-chelate (Gd-DTPA) vs a Weak Interacting (Gd-BOPTA) Michael V. Knopp1, Val Runge2, Marco Essig3, Mathias Hartmann4, Olaf Jansen4, Klaus-Peter Lodemann5 1National Institutes of Health, Bethesda, MD, USA; 2University of Kentucky, Georgetown, KY, USA; 3German Cancer Research Centre, Heidelberg, Germany; 4University of Heidelberg, Heidelberg, Germany; 5Bracco-Byk Gulden GmbH, Konstanz, Germany. 2287.Gross-Total Resection of High-Grade Gliomas under Intraoperative MRI-Guidance Katharina Eberle1, Volker Seifert1, Christos Trantakis1, Jürgen Dietrich1, Thomas Kahn1, Thomas Schulz1, Jens-Peter Schneider1 1University of Leipzig, Leipzig, Germany. 2288.Proton MR Spectroscopy and FDG-PET for the Assessment of Suspicious Lesions after Brain Tumor Radiotherapy Heinz-Peter Schlemmer1, Marcus Henze2, Klaus Herfarth2, Jürgen Debus1, Peter Bachert3, Gerhard Van Kaick1 1German Cancer Research Center, Heidelberg, Germany; 2University Clinic of Heidelberg, Heidelberg, Germany; 3Schriesheim, Germany. 2289.Semi-Quantative Proton Spectroscopy of Cerebellar Tumor of Childhood Dongzhu Jin1, Jill V. Hunter1, Zhiyue J. Wang1, Chunpang Shen1, Brendon Tavelli1, Robert A. Zimmerman1 1The Children's Hospital of Philadelphia, Philadelphia, PA, USA. 2290.Automatic Independent Component Analysis of 1H Spectroscopic Imaging Data from Human Brain Tumours Yrjo Hiltunen1, Juhani Pulkkinen1, Anna-Maija Häkkinen2, Nina Lundbom3, Risto Kauppinen1 1University of Kuopio, A.I. Virtanen Institute, Kuopio, Finland; 2Helsinki, Finland; 3Department of Radiology, Helsinki, Finland. 2291.Correlation Betwen In Vivo and In Vitro Proton MRS and Histology of Brain Tumors Tariq Shah1, Rama Jayasunder1, V. P. Singh1, Chitra Sarkar1 1All India Institute of Medical Sciences, Ansari Nagar, New Delhi India. 2292.Pure Oxygen as a Contrast Medium in Human Brain Tumor MR Imaging. Christoph Losert1, Michael Peller1, Philipp Schneider1, Martin Thoma1, Martin Busch1, Maximilian Reiser1 1Klinikum Grosshadern, Munich, Germany. 2293.Cost-effectiveness of MRS in the Management of Recurrent Brain Tumors Alexander Lin1, Maureen Brooks2, Brian Ross1 1Southern California Clinical Spectroscopy Service, Pasadena, CA, USA; 2InSource Medical Solutions, Newport, CA, USA. 2294.Differentiating Diffuse Brainstem Neoplasms using Proton Magnetic Resonance Spectroscopy Alexander Lin1, Frederick Shic1, Brian Ross1 1Huntington Medical Research Institutes, Pasadena, CA, USA. 2295.Analysis of Spatial Extent of the Metabolic Abnormality for Newly Diagnosed Glioma Patients Xiaojuan Li1, Ying Lu1, Sarah J. Nelson1 1University of California, San Francisco, CA, USA. 2296.Feature Space Analysis of MRI: Active Brain Tumors versus Radiation Necrosis H. Soltanian-Zadeh1, L. Smith1, D. J. Peck1, D. O. Hearshen1, L. Scarpace1, T. Mikkelsen1 1Henry Ford Health System, Detroit, MI, USA. 2297.Diagnostic Value of T1-Weighted Fluid-Attenuated Inversion Recovery Sequence in MR Imaging of Brain Tumors Fang Zhu1, Liming Xia1, Chengyuan Wang1, Guang Cao2, Jian-Ming Zhu3 1Tongji Hospital, Wuhan, China; 2GE Medical Systems China, Hong Kong, China; 3G. E. Medical Systems, Milwaukee, WI, USA. 2298.Multi-Slice Proton Spectroscopic Imaging of Delayed Radiation Necrosis Correlated with Intraoperative Histology David Hearshen1, Lisa Scarpace1, Suresh Patel1, Jack P. Rock1, Donald Peck1, Tom Mikkelsen1 1Henry Ford Hospital, Detroit, MI, USA. 2299.Evaluation of Tumor Oxygenation in Human Brain Zerrin Yetkin1, Dianne Mendelsohn1, Phillip Purdy1, Roderick McColl1, Ralph P. Mason1 1University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. 2300.Correlation of MIB-1 Proliferation Index and Cell Density with Choline Level Using a Quantitative 1H-MRS. Discrepancy in Benign and Malignant Glioma. Akira Matsumura1, Tomonori Isobe1, Izumi Anno1, Shingo Takano1, Yasushi Nagatomo2, Takashi Yoshizawa3, Yuji Itai1, Tadao Nose1 1University of Tsukuba, Tsukuba, Ibaraki, Japan; 2Seinan-Medical Center, Sakai, Ibaraki, Japan; 3Yokohama Shintoshi Neurosurgical Hospital, Saitama, Japan. 2301.Diffusion, Perfusion and H1-Spectroscopy in Patients with Newly Diagnosed Gliomas Isabelle Catalaa1, Roland G Henry1, Edward Graves1, Ying Lu2, Daniel Vigneron1, Sarah J. Nelson1 1University of California, San Francisco, San Francisco, CA, USA. 2302.Assessment of the Interest of rCBV Mapping for Establishing Differential Diagnosis Between High Grade Gliomas and Other Enhancing Brain Tumors Stéphane Kremer1, Sylvie Grand1, Chantal Rémy2, Li-Juan Zhou1, Basile Pasquier1, Alim Louis Benabid1, Jean-François Le Bas1 1CHU de Grenoble, Grenoble, France; 2Université J. Fourier, CHU de Grenoble, Grenoble, France. 2303.Estimation of Local Temperature in Brain Tumors Rama Jayasundar1, V. P. Singh1 1All India Institute of Medical Sciences, New Delhi, India. 2304.Characterization of Oligodendrogliomas using Short Echo Time 2D 1H MRSI M. Rijpkema1, J. Schuuring2, A. Heerschap1 1University Medical Center Nijmegen, Nijmegen, Netherlands. 2305.Incorporation of 1H Magnetic Resonance Spectroscopic Imaging Data in the Radiation Treatment Planning Process Edward E. Graves1, Andrea Pirzkall1, Sarah J. Nelson1, David Larson1, Lynn J. Verhey1 1University of California, San Francisco, CA, USA. 2306.In Vivo And In Vitro MRS of Central Neurocytomas Tariq Shah1, Rama Jayasundar1, V. P. Singh1, Chitra Sarkar1 1All India Institute of Medical Sciences, New Delhi, India. 2307.In Patients with Brain Tumors, Can the Contralateral Brain Hemisphere be Used as Control for Single-Voxel 1H Spectroscopy? Dirce Takako Fujiwara1, Claudio Campi de Castro2, Sergio Rosemberg2, Marcos Jose Rotta2, Rosa Maria Volpi Piva2, Giovanni Guido Cerri2 1Hospital das Clinicas, Sao Paulo, SP, Brazil; 2University of Sao Paulo, Sao Paulo, SP, Brazil. 2308.How Accurate is 1H MRS in the Individual Tumor Patient? Alexander Lin1, Brian Ross1 1Huntington Medical Research Institutes, Pasadena, CA, USA. 2309.Dynamic, Contrast-Enhanced MRI of Murine Gliomas: Correlation with Histology Soonmee Cha1, Glyn Johnson1, Youssef Zaim Wadghiri1, Olivier Jin1, David Zagzag1, Daniel Turnbull1 1New York University School of Medicine, New York, NY, USA. Breast Cancer Hall 4 Wednesday: 13:30 - 15:30 2310.MRI Correlates of Induration in the Irradiated Breast Anwar R Padhani1, John Yarnold1, Jane Regan1, Janet E Husband1 1Institute of Cancer Research, Sutton, Surrey, UK. 2311.Can Magnetic Resonance Mammography of Radial Scars Reduce Benign Biopsy Rates? David John Manton1, Lindsay W. Turnbull1 1Hull Royal Infirmary, Hull, UK. 2312.Comparison of the Characteristics of Node Negative and Positive Breast Cancers Measured by Dynamic Contrast Enhanced MRI with Three Analysis Methods M. Y. Su1, Y. C. Cheung2, J. P. Fruehauf3, H. Yu1, J. Y. Chiou1, E. Mechetner3, S. S. Chen2, O. Nalcioglu1, Y. L. Wan2 1University of California, Irvine, CA, USA; 2Chang Gung Memorial Hospital, Linkou, Taiwan; 3Oncotech Inc., Irvine, CA, USA. 2313.Combined Use of Dynamic Contrast Enhancement MRI, 1H MRS, and Perfusion MRI Improves Specificity in Detection of Breast Malignancy Terry M. Button1, Khaldoon Al Dulaimy1, B. Kandel1, Paul A. Fisher1, B. O'Hea1, M. Kemeny1, Christine Geronimo1, V. Geronimo1, Wei Huang1 1State University of New York at Stony Brook, Stony Brook, NY, USA. 2314.Comparative Analysis of Dynamic Contrast-Enhanced T1-Weighted and T2*-Weighted Perfusion Magnetic Resonance Imaging (MRI) in Patients with Breast Lesions. Preliminary Study. Erica Endo1, Su Jin Kim1, Maria Concepcion Garcia Otaduy1, Luciano Fernandes Chala1, Antonio Carlos Nisida1, Jose Aristodemo Pinotti1, Claudia da Costa Leite1, Claudio Campi de Castro1, Nestor de Barros1, Giovanni Guido Cerri1 1University of Sao Paulo, Sao Paulo, SP Brazil. 2315.Phyllodes Tumor of the Breast: MR Imaging Features with Pathologic Correlation Keiko Kishimoto1, Katsuyoshi Ito1, Nobuhiko Ogasawara1, Masayasu Yasui1, Shinji Koike1, Hisato Kobayashi2, Naofumi Matsunaga1 1Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan; 2Otsu Red-Cross Hospital, Otsu, Shiga, Japan. 2316.MRI Assessment of Breast Cancer Invasion: Skin and Chest Wall Paul T. Weatherall1, R. Scott Goodwin1, Gregory Evans1, Jerri Payne1, Gregory Metzger1, M. Hossein Saaborian1, Tamara Campbell1, George Peters1 1University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. 2317.High Resolution Spiral Imaging of Breast Cancer Lara Stables1, Bruce L. Daniel1, Gary H. Glover1, Robert J. Herfkens1 1Stanford University, Stanford, CA, USA. 2318.Optimization of Imaging Parameters and Contrast Agent Dose for Dynamic Contrast-Enhanced MR Imaging of the Breast Qing Yuan1, Sarah Englander1, Mitchell Schnall1 1University of Pennsylvania, Philadelphia, PA, USA. 2319.Gadobenate dimeglumine (MultiHance®) in Magnetic Resonance Mammography (MRM) Michael Knopp1, Michael Bourne2, Francesco Sardanelli3, Martin Wasser4, Isabella Salerio5, Anna La Noce5, Miles Andrew Kirchin5 1National Institutes of Health, Bethesda, MD, USA; 2University Hospital of Wales, Cardiff, Wales, England, UK; 3Biomedical SpA, Genova, Italy; 4Department of Radiology, Leiden, Netherlands; 5Bracco S.p.A., Milan, Italy. 2320.Assessing the Value of Early MR Measurements for Predicting Response to Neoadjuvant Treatment in Locally Advanced Breast Cancer Savannah C Partridge1, Laura J Esserman2, David C Newitt1, Nola M Hylton1 1University of California, San Francisco, San Francisco, CA, USA. 2321.A 3D Technique to Determine Global Contrast Pharmacokinetics and Parenchyma Volume in Breast Sarah Englander1, Qing Yuan1, Mitchell Schnall1 1University of Pennsylvania, Philadelphia, PA, USA. 2322.Choline-Containing Compounds Can be Detected with a Choline-Specific Sequence and CSI in Breast Tissue Tore Skjetne1, Inger Johanne Bakken1, Ingrid Gribbestad1 1SINTEF Unimed, Trondheim, Norway. 2323.Comparison of In Vivo and In Vitro 1H MR Spectroscopy of Breast Cancer Sandeep Hunjan1, Daniel Spielman1, Anne Sawyer-Glover1, Debra M. Ikeda1 1Stanford University, Stanford, CA, USA. 2324.The Fractal Dimension of the Elasticity Tensor in MR-Elastography for the Differential Diagnosis of Breast Tumors Ralph Sinkus1, Joern Lorenzen2, Dana Schrader3, Christoph Leussler1, Michael Dargatz1, Peter Roeschmann1 1Philips Research Laboratories, Hamburg Germany; 2Radiologische Klinik Eppendorf, Hamburg Germany; 3Frauenklinik Krankenhaus Eppendorf, Hamburg Germany. 2325.Diagnostic Efficacy of Pre-operative Contrast-enhanced Breast MRI Shih-chang Wang1, Bruno Mario Giuffré2, Steven Blome2, Jeanette Philips2, Marjorie B. Kossoff2 1National University of Singapore, National University Hospital, Singapore, Singapore; 2Royal North Shore Hospital, St. Leonards, NSW, Australia. 2326.Comparison of Apparent Diffusion Coefficient (ADC) with Histologic Cellularity in Breast Tumors Yong Guo1, Fulin Wang2, Youquan Cai2, Yuangui Gao2 1Naval General Hospital, Beijing, P.R.China; 2P.L.A General Hospital, Beijing, China. 2327.Lactate Detection in Human Breast Cancer on 2.1T MR System Pavel Shkarin1, Qiuhong He2 1Yale University, School of Medicine, New Haven, CT, USA; 2Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 2328.Proton Spectroscopic Imaging of Breast Cancer Daniel Spielman1, Sandeep Hunjan1, Anne Sawyer-Glover1, Elfar Adalsteinsson1, Debra M. Ikeda1 1Stanford University, Stanford, CA, USA. 2329.Breast MRI in Clinical Practice - Five Year Retrospective Frederick Kelcz1, Pamela A. Propeck1, Katherine A. Bueschel1 1University of Wisconsin-Madison, Madison, WI, USA. 2330.Volume Localized 2D 1H COSY in Human Breast Cancer In Vivo Kenneth Yue1, Nader Binesh1, Nanette Debruhl1, Albert Michael Thomas1 1University of California, Los Angeles, CA, USA. 2331.Perfusion and Diffusion Contributions to ADC: Application to Breast Tumors In Vivo. Shantanu Sinha1, Usha Sinha1, Flora Lucas-Quesada1, Nanette Debruhl1, Sarah Englander2, Mitchell Schnall2 1University of California, Los Angeles, Los Angeles, CA, USA; 2University of Pennsylvania, Philadelphia, PA, USA. 2332.Characterization of Benign and Malignant Breast Lesions Using 1H MRS at 4 Tesla Eva H Baker1, Lance DelaBarre1, Patrick J Bolan1, Hellmut Merkle1, Douglas Yee1, Lenore I Everson1, Michael Garwood1 1University of Minnesota, Minneapolis, MN, USA. 2333.Dynamic Contrast-Enhanced MR Imaging Used to Evaluate Response of Neoadjuvant Chemotherapy of Breast Cancer Kjell Kvistad1, Jana Rydland1, Hanne Brit Smethurst1, Ingrid S Gribbestad2, Gunnar Nilsen1, Steinar Lundgren1, Hans E Fjøsne1, Olav Haraldseth3 1University Hospital, Trondheim, Norway; 2SINTEF Unimed, Trondheim, Norway; 5Norwegian University of Science and Technology, Trondheim, Norway. 2334.An Anthropomorphic Breast Phantom for MRI and Mammography D. B. Plewes1, M. J. Yaffe1, S. J. Graham1, L. Little1, C. L. Nangini1, J. G. Mainprize1 1University of Toronto, Toronto, ON, Canada. Prostate Cancer Hall 4 Wednesday: 13:30 - 15:30 2335.Resonance Peaks Exhibited in the Upper Field of Citrate on Proton MR Spectra of the Prostate - Assignments and Pathological Correlation - Keiko Imamura1, Tatsuya Chikaraishi1, Akio Kazama1, Ichirou Tani1, Azuma Hashimoto1, Teruaki Iwamoto1, Hideo Atari1, Yasuo Nakajima1 1St. Marianna University, School of Medicine, Kawasaki, Kanagawa Japan. 2336.1H HR-MAS Investigation of Four Potential Markers for Prostate Cancer. Mark G. Swanson1, Daniel B. Vigneron1, Joyce K. James2, John Kurhanewicz1 1University of California, San Francisco, San Francisco, CA, USA; 2Bruker Instruments, Fremont, CA, USA. 2337.Endorectal 2D L-COSY of Citrate, Spermine, Choline and Lipids in Human Prostate In Vivo Nader Binesh1, Alan Marumoto1, Albert Thomas1, Kenneth Yue1, Jean Dekernion1, Zoran Barbaric1 1University of California, Los Angeles, Los Angeles, CA, USA. 2338.Prostate Cancer Pathology: Statistical Classification Strategy Applied to Ex Vivo Proton MR Spectra Roger Bourne1, Ray L. Somorjai2, Peter Russell1, Peter Swindle1, Simon Mccredie1, Philip Katelaris3, Susan Dowd1, Carolyn Mountford1 1University of Sydney, Sydney, NSW, Australia; 2National Research Council, Winnipeg, Manitoba, Canada; 3Sydney Adventist Hospital, Wahroonga, Sydney, Australia. 2339.Assessment of the Sensitivity and Specificity of In Vivo Proton MRS using External Surface Coil in Differentiating Malignant from Normal Prostatic Tissue Mahesh Kumar1, Rajeev Kumar1, A. K. Hemal1, N. R. Jagnnathan1 1All India Institute of Medical Sciences, New Dehli, India. 2340.Characterization of Prostate Deformation during MR Examination Using Endorectal Coil for Accurate Localization of Tumor during Brachytherapy Katrina Read1, Keyanoosh Hosseinzadeh1, Steven J DiBiase1, Rao P Gullapalli1 1University of Maryland, Baltimore, Baltimore, MD, USA.; 2341.Dynamic Contrast-Enhanced MR Imaging of the Prostate: Correlation with Tumour Stage, Histological Grade and PSA. Bin Wang1, Martin Lowry1, Lindsay Wilson Turnbull1 1University of Hull, Hull Royal Infirmary, Hull, England, UK. 2342.Quantitative Maps of ADC and Time Course T2 of Human Prostate Xenograft Model in Athymic Nude Mice Geon-Ho Jahng1, Song Lai1, Jiongjiong Wang1, Lahmer Lynds1, Gale R. Ramsby1, QiaoQiao Wang1, Kevin P. Claffey1 1University of Connecticut Health Center, Farmington, CT, USA. 2343.Combined Use of Diffusion-Weighted Imaging (DWI) and MR Spectroscopic Imaging (MRSI) in the Detection of Prostate Cancer for Disease-Targeted Therapy Keya Hosseinzadeh1, Katrina Read1, Steven DiBiase1, Rao Gullapalli1 1University of Maryland, Baltimore, Baltimore, MD, USA. Other Cancers Hall 4 Wednesday: 13:30 - 15:30 2344.Dynamic contrast-enhanced MR Imaging and Tumour Oxygenation Measurements in Cervical Cancer Susan M Todd1, Andrew P Jones1, Rachel A Cooper2, Julie A Loncaster2, Catherine M L West2, Johnathan R Sykes1, Bernadette M Carrington1 1Christie Hospital, Manchester, UK; 2Paterson Institute for Cancer Research, Manchester, UK; 2345.Grading of Head and Neck Tumors by 1H MRS: An Approach with Potential Clinical Utility Tedros Bezabeh1, S. El-Sayed2, O. Odlum2, S.I. Ahing2, R. Patel1, R. W. Nason2, D. Sutherland2, Ian Cormack Palmer Smith2 1National Research Council of Canada, Winnipeg, MB, Canada; 2University of Manitoba, Winnipeg, MB, Canada. 2346.Phase III Safety and Efficacy Study of Ferumoxtran-10 as an MR Contrast Agent for the Evaluation of Lymph Node Metastasis in the Neck and Body Yoshimi Anzai1, Laurie Loevner2, David M. Yousem3, Thomas McCauley4, Therese Weber5, Kenneth Maravilla1, Marie Morris6 1University of Washington, School of Medicine, Seattle, WA, USA; 2University of Pennsylvania, Philadelphia, PA, USA; 3Johns Hopkins University, School of Medicine, Baltimore, MD, USA; 4Yale University, New Haven, CT, USA; 5University of Alabama, Birmingham, AL, USA; 6Ad, Princeton, NJ, USA. 2347.Evaluation of Thyroid Masses Using In Vivo 1H MR Spectroscopy: Correlation with Pathology Wei Huang1, Patricia Roche1, Maisie Shindo1, Terry M. Button1 1State University of New York at Stony Brook, Stony Brook, NY, USA. 2348.1H MRS of Soft Tissue Sarcoma: A New Approach Towards Improved Diagnosis Tedros Bezabeh1, S. El-Sayed2, R. Patel1, Rajmund Somorjai1, Ian Cormack Palmer Smith2 1National Research Council of Canada, Winnipeg, MB Canada; 2University of Manitoba, Winnipeg, MB, Canada. 2349.31P MRS of Phospholipids' Extracts from Blast Cells of Patients with Acute Leukaemia - Significance of Sphingomyelin Malgorzata Kuliszkiewicz-Janus1, Stanislaw Baczynski2, Anna Jurczyk1, Iwona Prajs1, Bozena Jazwiec1 1Wroclaw Medical University, Wroclaw, Poland; 2University of Wroclaw, Wroclaw, Poland. 2350.Rapid Proton Fat-Water Spectroscopy for the Characterization of Non-CNS Lesions In Vivo Gerard Riedy1 1Wake Forest University, Bowman-Grey Medical Center, Winston-Salem, NC, USA. 2351.Evaluation of Ovarian Tumors by Quantitative In Vivo Proton MR Spectroscopy Toshiko Okada1, Masafumi Harada1, Kenji Matsuzaki1, Hiromu Nishitani1, Toshihiro Aono1 1University of Tokushima, Tokushima, Japan. 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A B D E G I J L M O Q S U V X Y [ \ ^ ` b c e g i j l n p r s u v x z | } ƒ … † ˆ ‰ ‹ Œ Ž ‘ “ • – ˜ ™ › œ ž ¡ £ ¤ ¦ § © « ¯ ° ² ´ µ · ¹ º ½ ¿ Á Ã Ä Æ Ç É Ë Í Î Ð Ò Ó Ö × Ù Û Ý Þ à â ä å ç é ê ì î ï ñ ó õ ö ø ú ü ý þ Ê #*-á!ÿ•€!ÿ•€ð8ðAB@ñÿÿÿ€€€÷ð¸TðAðVTð( ð@!8¦| €N¦| ððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ð ððPB ð 3ðËœ1?¿ "ñ¿€ð ððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ð ððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð! 3ðËœ1?¿ "ñ¿€ð$ððPB ð" 3ðËœ1?¿ "ñ¿€ð%ððPB ð$ 3ðËœ1?¿ "ñ¿€ð&ððPB ð% 3ðËœ1?¿ "ñ¿€ð'ððPB ð& 3ðËœ1?¿ "ñ¿€ð(ððPB ð' 3ðËœ1?¿ "ñ¿€ð)ððPB ð( 3ðËœ1?¿ "ñ¿€ð+ððPB ð) 3ðËœ1?¿ "ñ¿€ð,ððPB ð* 3ðËœ1?¿ "ñ¿€ð-ððPB ð+ 3ðËœ1?¿ "ñ¿€ð.ððPB ð, 3ðËœ1?¿ "ñ¿€ð/ððPB ð. 3ðËœ1?¿ "ñ¿€ð7ððPB ð/ 3ðËœ1?¿ "ñ¿€ð9ððPB ð0 3ðËœ1?¿ "ñ¿€ð;ððPB ð1 3ðËœ1?¿ "ñ¿€ð=ððPB ð2 3ðËœ1?¿ "ñ¿€ð>ððPB ð3 3ðËœ1?¿ "ñ¿€ð?ððPB ð4 3ðËœ1?¿ "ñ¿€ð@ððPB ð5 3ðËœ1?¿ "ñ¿€ðAððPB ð6 3ðËœ1?¿ "ñ¿€ðBððPB ð7 3ðËœ1?¿ "ñ¿€ðCððPB ð8 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"ñ¿€ð…ððPB ðf 3ðËœ1?¿ "ñ¿€ð†ððPB ðg 3ðËœ1?¿ "ñ¿€ð‡ððPB ðh 3ðËœ1?¿ "ñ¿€ðˆððPB ði 3ðËœ1?¿ "ñ¿€ð‰ððPB ðl 3ðËœ1?¿ "ñ¿€ð*ððPB ðm 3ðËœ1?¿ "ñ¿€ð5ððPB ðn 3ðËœ1?¿ "ñ¿€ð6ððPB ðo 3ðËœ1?¿ "ñ¿€ð8ððPB ðp 3ðËœ1?¿ "ñ¿€ð:ððPB ðq 3ðËœ1?¿ "ñ¿€ð<ððPB ðr 3ðËœ1?¿ "ñ¿€ðOð ðPB ðs 3ðËœ1?¿ "ñ¿€ðYð ðPB ðt 3ðËœ1?¿ "ñ¿€ðZð ðPB ðu 3ðËœ1?¿ "ñ¿€ð\ð ðPB ðv 3ðËœ1?¿ "ñ¿€ð^ð ðPB ðw 3ðËœ1?¿ "ñ¿€ð`ð ðPB ðx 3ðËœ1?¿ "ñ¿€ðrððPB ðy 3ðËœ1?¿ "ñ¿€ðxððPB ðz 3ðËœ1?¿ "ñ¿€ðzððPB ð{ 3ðËœ1?¿ "ñ¿€ð|ððPB ð| 3ðËœ1?¿ "ñ¿€ð~ððPB ð} 3ðËœ1?¿ "ñ¿€ð€ððPB ð~ 3ðËœ1?¿ "ñ¿€ðŠððPB ð 3ðËœ1?¿ "ñ¿€ð‹ððPB ð€ 3ðËœ1?¿ "ñ¿€ðŒððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð‚ 3ðËœ1?¿ "ñ¿€ðŽððPB ðƒ 3ðËœ1?¿ "ñ¿€ðððPB ð„ 3ðËœ1?¿ "ñ¿€ðððPB ð… 3ðËœ1?¿ "ñ¿€ð‘ððPB ð† 3ðËœ1?¿ "ñ¿€ð’ððPB ð‡ 3ðËœ1?¿ "ñ¿€ð“ððPB ðˆ 3ðËœ1?¿ "ñ¿€ð”ððPB ð‰ 3ðËœ1?¿ "ñ¿€ð•ððPB ðŠ 3ðËœ1?¿ "ñ¿€ð–ððPB ð‹ 3ðËœ1?¿ "ñ¿€ð—ððPB ðŒ 3ðËœ1?¿ "ñ¿€ð˜ððPB ð 3ðËœ1?¿ "ñ¿€ð™ððPB ðŽ 3ðËœ1?¿ "ñ¿€ðšððPB ð 3ðËœ1?¿ "ñ¿€ð›ððPB ð 3ðËœ1?¿ "ñ¿€ðœððPB ð‘ 3ðËœ1?¿ "ñ¿€ðððPB ð’ 3ðËœ1?¿ "ñ¿€ðžððPB ð“ 3ðËœ1?¿ "ñ¿€ðŸððPB ð” 3ðËœ1?¿ "ñ¿€ð ððPB ð• 3ðËœ1?¿ "ñ¿€ð¡ððBB ð– 3ðËœ1?¿ ð¢ð0ðBB ð— 3ðËœ1?¿ ð£ð/ðPB ð˜ 3ðËœ1?¿ "ñ¿€ð¤ððBB ð™ 3ðËœ1?¿ ð¥ð1ðBB ðš 3ðËœ1?¿ ð¦ð9ðBB ð› 3ðËœ1?¿ ð§ð8ðBB ðœ 3ðËœ1?¿ ð¨ð9ðBB ð 3ðËœ1?¿ ð©ð:ðBB ðž 3ðËœ1?¿ ðªð8ðBB ðŸ 3ðËœ1?¿ ð«ð9ðBB ð 3ðËœ1?¿ ð¬ð8ðBB ð¡ 3ðËœ1?¿ ððGðBB ð¢ 3ðËœ1?¿ ð®ð9ðPB ð£ 3ðËœ1?¿ "ñ¿€ð¯ððPB ð¤ 3ðËœ1?¿ "ñ¿€ð°ððBB ð¥ 3ðËœ1?¿ ð±ð;ðBB ð¦ 3ðËœ1?¿ ð²ð<ðBB ð§ 3ðËœ1?¿ ð³ð<ðBB ð¨ 3ðËœ1?¿ ð´ð;ðBB ð© 3ðËœ1?¿ ðµð;ðBB ðª 3ðËœ1?¿ ð¶ð<ðBB ð« 3ðËœ1?¿ ð·ð;ðBB ð¬ 3ðËœ1?¿ ð¸ð/ðBB ð 3ðËœ1?¿ ð¹ð;ðBB ð® 3ðËœ1?¿ ðºð<ðBB ð¯ 3ðËœ1?¿ ð»ð<ðBB ð° 3ðËœ1?¿ ð¼ð;ðBB ð± 3ðËœ1?¿ ð½ð;ðBB ð² 3ðËœ1?¿ ð¾ð<ðBB ð³ 3ðËœ1?¿ ð¿ð;ðBB ð´ 3ðËœ1?¿ ðÀð;ðBB ðµ 3ðËœ1?¿ ðÁð;ðBB ð¶ 3ðËœ1?¿ ðÂð;ðBB ð· 3ðËœ1?¿ ðÃð;ðBB ð¸ 3ðËœ1?¿ ðÄð;ðBB ð¹ 3ðËœ1?¿ ðÅð<ðBB ðº 3ðËœ1?¿ ðÆð;ðBB ð» 3ðËœ1?¿ ðÇð<ðBB ð¼ 3ðËœ1?¿ ðÈð;ðBB ð½ 3ðËœ1?¿ ðÉð<ðBB ð¾ 3ðËœ1?¿ ðÊð<ðBB ð¿ 3ðËœ1?¿ ðËð;ðBB ðÀ 3ðËœ1?¿ ðÌð;ðBB ðÁ 3ðËœ1?¿ ðÍð;ðBB ðÂ 3ðËœ1?¿ ðÎð;ðPB ðÃ 3ðËœ1?¿ "ñ¿€ðÏððPB ðÄ 3ðËœ1?¿ "ñ¿€ðÐððBB ðÅ 3ðËœ1?¿ ðÑð@ðPB ðÆ 3ðËœ1?¿ "ñ¿€ðÒððPB ðÇ 3ðËœ1?¿ "ñ¿€ðÓððBB ðÈ 3ðËœ1?¿ ðÔð?ðBB ðÉ 3ðËœ1?¿ ðÕð@ðPB ðÊ 3ðËœ1?¿ "ñ¿€ðÖððPB ðË 3ðËœ1?¿ "ñ¿€ð×ððPB ðÌ 3ðËœ1?¿ "ñ¿€ðØððPB ðÍ 3ðËœ1?¿ "ñ¿€ðÙððPB ðÎ 3ðËœ1?¿ "ñ¿€ðÚððBB ðÏ 3ðËœ1?¿ ðÛðDðBB ðÐ 3ðËœ1?¿ ðÜðDðBB ðÑ 3ðËœ1?¿ ðÝðDðBB ðÒ 3ðËœ1?¿ ðÞðEðBB ðÓ 3ðËœ1?¿ ðßðEðBB ðÔ 3ðËœ1?¿ ðàðGðBB ðÕ 3ðËœ1?¿ ðáðEðBB ðÖ 3ðËœ1?¿ ðâðDðBB ð× 3ðËœ1?¿ ðãðDðBB ðØ 3ðËœ1?¿ ðäðFðBB ðÙ 3ðËœ1?¿ ðåðCðBB ðÚ 3ðËœ1?¿ ðæðCðBB ðÛ 3ðËœ1?¿ ðçðDðBB ðÜ 3ðËœ1?¿ ðèðDðBB ðÝ 3ðËœ1?¿ ðéðCðBB ðÞ 3ðËœ1?¿ ðêðDðBB ðß 3ðËœ1?¿ ðëðDðBB ðà 3ðËœ1?¿ ðìðCðBB ðá 3ðËœ1?¿ ðíðCðBB ðâ 3ðËœ1?¿ ðîðCðBB ðã 3ðËœ1?¿ ðïðCðBB ðä 3ðËœ1?¿ ðððCðBB ðå 3ðËœ1?¿ ðñðCðPB ðæ 3ðËœ1?¿ "ñ¿€ðòððPB ðç 3ðËœ1?¿ "ñ¿€ðóððBB ðè 3ðËœ1?¿ ðôðCðBB ðé 3ðËœ1?¿ ðõðBðBB ðê 3ðËœ1?¿ ðöðBðBB ðë 3ðËœ1?¿ ð÷ðCðBB ðì 3ðËœ1?¿ ðøðBðBB ðí 3ðËœ1?¿ ðùðCðBB ðî 3ðËœ1?¿ ðúðCðBB ðï 3ðËœ1?¿ ðûðBðBB ðð 3ðËœ1?¿ ðüðCðBB ðñ 3ðËœ1?¿ ðýðCðBB ðò 3ðËœ1?¿ ðþðCðBB ðó 3ðËœ1?¿ ðÿðCðBB ðô 3ðËœ1?¿ ððCðBB ðõ 3ðËœ1?¿ ððBðPB ðü 3ðËœ1?¿ "ñ¿€ðððPB ðý 3ðËœ1?¿ "ñ¿€ðððPB ðþ 3ðËœ1?¿ "ñ¿€ðððPB ðÿ 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ð0ððPB ð 3ðËœ1?¿ "ñ¿€ð1ððPB ð 3ðËœ1?¿ "ñ¿€ð2ððPB ð 3ðËœ1?¿ "ñ¿€ð3ððPB ð 3ðËœ1?¿ "ñ¿€ð4ððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ðððPB ð 3ðËœ1?¿ "ñ¿€ð"ððPB ð 3ðËœ1?¿ "ñ¿€ðFððPB ð 3ðËœ1?¿ "ñ¿€ðjððPB ð* 3ðËœ1?¿ "ñ¿€ðððPB ð+ 3ðËœ1?¿ "ñ¿€ðððPB ð, 3ðËœ1?¿ "ñ¿€ðððPB ð- 3ðËœ1?¿ "ñ¿€ðððPB ð. 3ðËœ1?¿ "ñ¿€ðððBB ð/ 3ðËœ1?¿ ðð@ðPB ð0 3ðËœ1?¿ "ñ¿€ðððPB ð1 3ðËœ1?¿ "ñ¿€ðððPB ð2 3ðËœ1?¿ "ñ¿€ðððPB ð3 3ðËœ1?¿ "ñ¿€ðððPB ð4 3ðËœ1?¿ "ñ¿€ðððPB ð5 3ðËœ1?¿ "ñ¿€ð ððPB ð6 3ðËœ1?¿ "ñ¿€ð!ððPB ð7 3ðËœ1?¿ "ñ¿€ðUððPB ð8 3ðËœ1?¿ "ñ¿€ðVððPB ð9 3ðËœ1?¿ "ñ¿€ðWððPB ð: 3ðËœ1?¿ "ñ¿€ðXððPB ð< 3ðËœ1?¿ "ñ¿€ðððPB ð= 3ðËœ1?¿ "ñ¿€ð#ððPB ð> 3ðËœ1?¿ "ñ¿€ðGððPB ð? 3ðËœ1?¿ "ñ¿€ðHððPB ð@ 3ðËœ1?¿ "ñ¿€ðkððPB ðA 3ðËœ1?¿ "ñ¿€ðððB ðSð¿Ëÿ ?ðÔq&ð1è?¾N~O%PÎPÐc+urƒªŽ¶™†§D²à¾ÅÌ6Í¦Í1ÎíÎ?ÒoÖ3Ù&ÜáÞûâíÌøˆû}¤À2*Û*v+4<ÑY’i§|ó†Ï¶’·“—“¬}¹sÅeÆŸÆÇ£ÇaÈõË Ï4Ð·ÑÓ/Õ'Ö%ØãÚ¦ÜÎã|ñìòëõ bÜrX)³94HÆWt`¨lo™pžJŒÙ™s¤è¤]¥Û¥™¦ò©®˜¯±+³´ÿµ÷¸âºóÄ?Ó×êÙoã@ðŠû]üýÞ •*Ÿ8ïAKtNXOXY(e–sU~Ç€Æñ„†‹‡ÓˆðŠª‹vÍ’až>«–´d¾†ÊMÖÝëörÛ] U*#.ŒCmP]ùoŠ‹˜«Ë¾•Òúßyë x—/A<¶HiWQq¾~ Ã–}›Òž^¤ ©–¬á°S²fµÀÈ\Ú 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