ࡱ> 9 ; $ % & ' ( ) * + , - . / 0 1 2 3 4 5 6 7 8  !\bjbj fo  YYYD l^$+R+++/ z<@;======$ʴla9YAt/|/AAa  ++IIIA 8+Y+;IA;IIPA+lg8:B3J'$Hl}<tF"<<Y(AAIAAAAAaaIAAAlAAAA<AAAAAAAAA :  Preventing Alcohol, Tobacco, and Other Substance-exposed Pregnancies: A Community Affair Hosted by: Interagency Coordinating Committee on Fetal Alcohol Syndrome Work Group on Women, Drinking, and Pregnancy Sponsored by: National Institute on Alcohol Abuse and Alcoholism, NIH and American Legacy Foundation September 23-24, 2008 Rockville, Maryland Report from the Conference  This report is based on the proceedings of the September 23 and 24, 2008, symposium hosted by the Women, Drinking, and Pregnancy Work Group of the Interagency Coordinating Committee on Fetal Alcohol Syndrome. The symposium: Preventing Alcohol, Tobacco, and Other Substance-exposed Pregnancies was held in Rockville, Maryland, and sponsored by the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, and American Legacy Foundation. About the development of the report: The initial draft of the report, based on verbatim transcripts from the symposium, was written by Linda Richardson, a science writer for Lewis-Williams Conference and Logistics Management, LLC, who attended the symposium. Each formal symposium participant was invited to correct errors in the text describing his/her presentation. The final report was edited by Dr. Deidra Roach, Division of Treatment and Recovery Research, NIAAA, and Leader of the Women, Drinking, and Pregnancy Work Group of the Interagency Coordinating Committee on Fetal Alcohol Syndrome and by Dr. Sally M. Anderson, Coordinator and Executive Secretary of the Interagency Coordinating Committee on Fetal Alcohol Syndrome. The U.S. Government does not endorse or favor any specific commercial products (or commodity, service, or company). Trade or proprietary names (or company names) appearing in this publication are used only because they are considered essential in the context of the presentation reported herein. The opinions expressed herein are those of the participants in the symposium and do not necessarily reflect an official position of NIAAA, NIH, any other part of the United States Government, or American Legacy Foundation. All material in this report is in the public domain and may be reproduced without permission from NIAAA, American Legacy Foundation, or the authors. Citation of the source is appreciated. Table of Contents  TOC \o "1-3"  Executive Summary  PAGEREF _Toc122760893 \h 7 MEETING PROCEEDINGS  PAGEREF _Toc122760894 \h 12 Welcome and Introductory Comments  PAGEREF _Toc122760895 \h 12 Deidra Roach, M.D., NIAAA and Kenneth R. Warren, Ph.D., NIAAA Historical Background  PAGEREF _Toc122760896 \h 13 Kenneth R. Warren, Ph.D., NIAAA The Evidence Substance Use among Women of Childbearing Age  PAGEREF _Toc122760897 \h 15 Prevalence of Substance Use among Women of Childbearing Age  PAGEREF _Toc122760898 \h 15 R. Louise Floyd, R.N., D.S.N., CDC Women and Substance Abuse: Risk Factors and Health Impacts  PAGEREF _Toc122760899 \h 17 Carrie Randall, Ph.D., Medical University of South Carolina Prenatal Exposure: Effects of Commonly Used Substances  PAGEREF _Toc122760900 \h 19 Claire D. Coles, Ph.D., Emory University School of Medicine Panel Discussion on At-Risk Populations, and Treatment and Preventions  PAGEREF _Toc122760901 \h 21 Carrie Randall, Ph.D., Medical University of South Carolina Some Federal Agency Activities on Identification of At-Risk Alcohol and other Substance Use and Intervening With Women of Childbearing Age  PAGEREF _Toc122760902 \h 23 Centers for Disease Control and Prevention (CDC)  PAGEREF _Toc122760903 \h 23 R. Louise Floyd, R.N., D.S.N., CDC Substance Abuse and Mental Health Services Administration (SAMHSA)  PAGEREF _Toc122760904 \h 24 Patricia Getty, Ph.D., Center for Substance Abuse Prevention, SAMHSA Health Resources and Services Administration (HRSA)  PAGEREF _Toc122760905 \h 26 John McGovern, M.G.A., Maternal and Child Health Bureau, HRSA National Institute on Alcohol Abuse and Alcoholism (NIAAA)  PAGEREF _Toc122760906 \h 27 Susan E. Maier, Ph.D., Division of Metabolism and Health Effects, NIAAA Intervention Research  PAGEREF _Toc122760907 \h 28 Intervening in the Preconception Period  PAGEREF _Toc122760908 \h 28 Karen Ingersoll, Ph.D., University of Virginia Intervening with Pregnant Women  PAGEREF _Toc122760909 \h 31 Grace Chang, M.D., M.P.H., Brigham and Womens Hospital and Harvard Medical School Intervening with Women with/or At-Risk for HIV Infection  PAGEREF _Toc122760910 \h 33 Mary E. McCaul, Ph.D., Johns Hopkins University School of Medicine Reaching out to Special Populations  PAGEREF _Toc122760911 \h 34 The Mississippi Experience  PAGEREF _Toc122760912 \h 34 Debbie Long, Mississippi FASD Prevention Project An Urban California Experience  PAGEREF _Toc122760913 \h 35 Lee Kaskutas, Ph.D., University of California, Berkeley Presented by Constance Weisner, Ph.D., University of California, San Francisco The Cheyenne River and Turtle Mountain Chippewa Reservation Experience  PAGEREF _Toc122760914 \h 36 Sherlynn Herrera, Reclaiming the Sacred Trust Project Renee Parker, Strong Beginnings Project (Zoongii Majiitawin Project) Health Services Delivery and Marketing  PAGEREF _Toc122760915 \h 37 Measuring the Cost-Effectiveness of Interventions in the Health Care System: Making the Business Case  PAGEREF _Toc122760916 \h 37 Constance Weisner, Ph.D., University of California, San Francisco Marketing the Message: Lessons Learned from the National Center for Health Marketing  PAGEREF _Toc122760917 \h 39 Lynn Sokler, National Center for Health Marketing, CDC Marketing the Message: Lessons Learned from the Office on Smoking and Health  PAGEREF _Toc122760918 \h 40 Judith Berkowitz, Ph.D., Centers for Disease Control and Prevention Michelle Johns, M.A., M.P.H., Centers for Disease Control and Prevention Marketing the Message: American Legacy Foundation  PAGEREF _Toc122760919 \h 42 Laura Hamasaka, American Legacy Foundation Jeffrey Costantino, M.B.A., American Legacy Foundation Panel Discussion: the Role of the Media in Promoting and Reducing Tobacco Use  PAGEREF _Toc122760920 \h 43 Ellen Hutchins, Sc.D., M.S.W., Facilitator Reaching-out Best Approaches and Global Strategies  PAGEREF _Toc122760921 \h 44 Reaching out to Women at Risk: A Mothers Perspective  PAGEREF _Toc122760922 \h 44 Mary De Joseph, D.O., Philadelphia College of Osteopathic Medicine Keynote Address I: Best Approaches to Marketing the Message Drinking, Smoking, and Pregnancy Do Not Mix"  PAGEREF _Toc122760923 \h 46 Lynn Sokler, National Center for Health Marketing, CDC Keynote Address II: Global Strategies in Health Marketing  PAGEREF _Toc122760924 \h 47 William A. Smith, Ed.D., Academy for Educational Development International Birth Mothers Network  PAGEREF _Toc122760925 \h 49 Kathleen Mitchell, M.H.S., L.C.A.D.C., NOFAS Legislative Update  PAGEREF _Toc122760926 \h 51 George Hacker, J.D., Center for Science in the Public Interest Future Directions and Framing an Action Agenda  PAGEREF _Toc122760927 \h 52 Breakout Sessions: Future Directions  PAGEREF _Toc122760928 \h 52 Framing an Action Agenda: Next Steps  PAGEREF _Toc122760929 \h 53 Deidra Roach, M.D., NIAAA Reports from Breakout Sessions  PAGEREF _Toc122760930 \h 55 Preventing Prenatal Exposure to Alcohol, Tobacco, and other Substances of Abuse in (Universal and Selected) Populations.............  PAGEREF _Toc122760931 \h 55 Susan Maier, Ph.D., NIAAA and Mary Kate Weber, M.P.H., CDC, Facilitators Intervening with Women with Problem Drinking and other Substances Misuse (Indicated Populations)  PAGEREF _Toc122760932 \h 56 Norma Finkelstein, Ph.D. and Ellen Hutchins, Sc.D., M.S.W., Facilitators Engaging Partners, Parents, Peers, and Policymakers  PAGEREF _Toc122760933 \h 57 John McGovern, M.G.A., HRSA, and Judith Thierry, D.O., M.P.H., Facilitators Wrap-Up and Closing Remarks  PAGEREF _Toc122760934 \h 58 Deidra Roach, M.D., NIAAA References  PAGEREF _Toc122760935 \h 59 Appendix  PAGEREF _Toc122760936 \h 63 Abbreviation/Acronym List ACOGAmerican College of Obstetrics and Gynecology AEPAlcohol-exposed Pregnancies ARBDAlcohol-related Birth Defects ARNDAlcohol-related Neurodevelopmental Disorder AUDIT-CAlcohol Use Disorders Identification Test-C BIBrief Intervention BMNBirth Mothers Network BPHBureau of Primary HealthBRFSSBehavioral Risk Factor Surveillance System CDCCenters for Disease Control and Prevention CHCsCommunity Health Centers CHOICESChanging High-risk Alcohol Use and Increasing Contraception Effectiveness StudyCIFASDCollaborative Initiative on Fetal Alcohol Spectrum Disorders CMSCenters for Medicare and Medicaid ServicesCSPICenter for Science in the Public Interest DEERDetermining Effective Educational ResourcesDHHSUnited States Department of Health & Human ServicesDSM-IVDiagnostic and Statistics Manual IV FAEFetal Alcohol Effects FASFetal Alcohol SyndromeFASDFetal Alcohol Spectrum DisordersFASERFAS Epidemiology Research Center FRAMESFeedback; Responsibility; Advice; Menu; Empathy; Self-efficacyGEDGeneral Equivalency Diploma HAARTHighly Active Antiretroviral TherapyHMO HRSAHealth Maintenance Organization Health Resources and Services AdministrationICCFASInteragency Coordinating Committee on Fetal Alcohol Syndrome ICDInternational Classification of DiseasesKPNCKaiser Permanente Northern California MCHBMaternal and Child Health Bureau NCAANational Collegiate Athletic AssociationNCBDDDNational Center on Birth Defects and Developmental DisabilitiesNCINational Cancer Institute NESARCNational Epidemiologic Survey on Alcohol and Related ConditionsNHISNational Health Interview Survey NIAAANational Institute on Alcohol Abuse and AlcoholismNICHDNational Institute of Child Health and Human DevelopmentNICUNeonatal Intensive Care UnitNIHNational Institutes of HealthNOFAS NSDUHNational Organization on Fetal Alcohol Syndrome National Survey of Drug Use and Health NTFFAS/FAENational Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effect PASS PCAPPrenatal Alcohol and SIDS and Stillbirth Network Parent-Child Assistance Programs PHFEPublic Health Foundation Enterprises RCTRandomized Control Trial RTCsRegional Training Centers SAMHSASubstance Abuse and Mental Health Services AdministrationSATScreened, Assessed, and Treated SBILTScreening, Brief Intervention, and Linkage to TreatmentSBIRTScreening, Brief Intervention and Referral to TreatmentSBIRScreening, Brief Intervention, ReferralSEMSocioecological Marketing SESSocioeconomic Status SIDSSudden Infant Death Syndrome SSBSafer Sex Skills BuildingSTDSexually Transmitted Disease T-ACEAlcohol Use Screening Tools - Tolerance; Annoyed; Cut down; Eye-openerTIPTreatment Improvement Protocols TWEAKAlcohol Use Screening Tool - Tolerance; Worried; Eye Opener; AmnesiaWHO WICWorld Health Organization Women, Infants, and Children Program Executive Summary On September 23 and 24, 2008, the Work Group on Women, Drinking, and Pregnancy of the Interagency Coordinating Committee on Fetal Alcohol Syndrome (ICCFAS), the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the American Legacy Foundation (Legacy), a nonprofit health organization dedicated to building a world where young people reject tobacco and anyone can quit, collaborated and hosted a symposium to explore best approaches to disseminating the message about the potential harm caused by risky drinking, tobacco, and other substance use during the childbearing years and, in particular, the importance of abstaining from any and all drinking and smoking during pregnancy. The joint objective was to initiate a national effort to change the common perception that the use of alcohol and tobacco during pregnancy is safe. Approximately 103 addiction prevention and treatment professionals, health policymakers, health communications and marketing professionals, addiction researchers, community activists, Federal agency representatives, and others participated in the symposium. Twenty-two presentations were organized into eight general topic areas: Historical Background Epidemiology and Impact of Prenatal Substance Use on Birth Outcomes in the U.S. Federal Agency Activities to Address Substance Misuse Among Women of Childbearing Age Intervening with Women in the Preconception Period and During Pregnancy Reaching Out to Special Populations Measuring the Cost-Effectiveness of Interventions for Substance Misuse among Women of Childbearing Age Marketing the Message: Alcohol, Tobacco, and other Substance Use and Pregnancy Do Not Mix Future Directions for Preventing Alcohol, Tobacco, and other Substance-exposed Pregnancies: Framing an Action Agenda This report summarizes key information from the presentations and discussions related to each of the eight topic areas. It is intended to serve as a blueprint for future collaborative activities that will bring Federal, state, and community partners together to develop and implement a coordinated and effective response to one of the nations most daunting public health challenges: substance misuse among women of childbearing age. Several of the key themes that emerged over the course of these highly interactive and informative discussions are highlighted below. Historical Background In 1977, NIAAA organized the first international conference on FAS. The recommendations from this conference led to the first U.S. Government advisory on drinking during pregnancy (DHEW 1977). The advisory was written from a conservation perspective and states that alcohol use during pregnancy was safe until proven dangerous, and advised pregnant women who drink alcohol to consume no more than 2 alcoholic drinks a day. In May 1981, the U.S. Surgeon General issued a new advisory that basically urged pregnant women not to drink alcohol (DHHS 1981). In February 2005, the U.S. Surgeon General reissued its health advisory based on the recommendations of the National Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effects ( HYPERLINK "http://www.surgeongeneral.gov/pressreleases/sg02222005.html" http://www.surgeongeneral.gov/pressreleases/sg02222005.html ). This advisory, which is still in place today, recommends that a pregnant woman should not drink alcohol during pregnancy; that a woman who is considering becoming pregnant should abstain from alcohol; and that health professionals should routinely ascertain whether pregnant women and women who are considering becoming pregnant are consuming alcohol and advise them not to drink alcoholic beverages. A major issue today is that it is still not widely understood and accepted that abstinence from alcohol during pregnancy is the safest course of action. While no level of alcohol consumption has been demonstrated to be safe during pregnancy, the U.S. media, society, and some physicians continue to convey mixed messages about alcohol use and pregnancy. The challenges for today are to explore the best approaches to improve delivery of the message of the importance of abstaining from all drinking and smoking during pregnancy and to improve delivery systems for the treatment of women with alcohol use disorders. Epidemiology of Substance Use among Women of Childbearing Age In the U. S., alcohol, tobacco, and illicit drug use are among the leading causes of morbidity and mortality and among the 10 leading health indicators cited in Healthy People 2010. Maternal use of these substances during early pregnancy (46 weeks gestation) exposes the fetus to a range of adverse outcomes. While most women discontinue drinking after learning that they are pregnant, approximately one-half of all pregnancies are unplanned, and most women do not know they are pregnant until 46 weeks after conception. This means that, even among women who are inclined and able to discontinue drinking after learning they are pregnant, a high percentage of pregnancies are alcohol exposed. Thus, while it is known that approximately 15 percent of women continue to drink after learning they are pregnant, the actual total number of alcohol-exposed pregnancies is probably significantly higher than this number suggests. One of the strongest predictors of substance use during pregnancy is substance use before pregnancy (Day et al. 1993; Floyd et al. 1999). Despite the information, screening tools, and interventions available to the public, no substantial progress has been made to reduce hazardous alcohol use among women of childbearing age. The data show that substance use is prevalent among preconception women; most, but not all, women decrease substance use when they learn they are pregnant (Ebrahim et al. 1999; Floyd et al. 1999); vulnerable groups can be identified and targeted; and many women at risk are seen by providers who could either intervene directly or refer them to appropriate treatment. Development of better strategies to achieve a greater public health impact will require a careful review of the lessons learned from both research and real world community experience. Impact of Prenatal Substance Use on Women and Birth Outcomes Women progress faster, compared with men, from first substance use to regular and dependent use and first treatment, a phenomenon referred to as telescoping. One reason for this telescoped development of alcohol problems in women is that alcohol is especially toxic to womens bodies, causing damage to many of their organs at lower doses than those that cause damage in men. The blood alcohol concentration produced by a given amount of alcohol is higher for women than for men of the same size because of certain physiological factors (e.g., amount of fatty tissue, body water, alcohol dehydrogenase) that increase the tissue exposure to alcohol in women. Organs that may be adversely affected by alcohol include, but are not limited to, the liver, brain, heart, skeletal muscle, and pancreas. In addition, although women generally use smaller quantities of substances for fewer years compared with men, they have, on average, more medical, psychiatric, and social consequences. In addition to having unique risk factors and sequelae of substance abuse, women have additional unique issues in relation to pregnancy outcomes and fetal growth and development. Most women who use alcohol and drugs in pregnancy use more than one drug, with cigarettes and alcohol being most common, followed in order by marijuana, and prescription drugs, stimulants (e.g., cocaine, methamphetamines), and opiates. Most drugs of abuse easily cross the placenta and reach the fetus. Screening with good biomarkers is essential during pregnancy because, regardless of the substance being abused, pregnant women are at increased risk of both poor pregnancy outcomes and poor fetal outcomes. Such adverse birth outcomes may include prematurity, fetal growth retardation, low birth weight, and other conditions that require treatment in a neonatal intensive care unit (NICU). Alcohol, which crosses the placenta more easily than other commonly abused substances, is a classic (physical) teratogen resulting in birth defects, as documented in animal studies. Along with certain other substances (e.g., cocaine, marijuana, nicotine), it is also recognized as a behavioral teratogen. Federal Agency Activities on Identification of At-Risk Alcohol and other Substance Use and Intervening with Women of Childbearing Age Federal agency representatives presented an overview of Federal initiatives to reduce alcohol and other substance misuse among women of childbearing age. The report includes descriptions of several representative programs from each of four Federal agencies, the Centers for Disease Control and Prevention (CDC), the Substance Abuse and Mental Health Services Administration (SAMHSA), the Health Resources and Services Administration (HRSA), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Intervening with Women in the Preconception Period and During Pregnancy The report provides highlights and conclusions from a series of studies aimed at preventing alcohol-exposed pregnancies (AEP) by intervening in the preconception period. The studies sought to capture non-pregnant, drinking women who were at risk for pregnancy but not actively planning pregnancy nor seeking treatment for drinking and to test interventions based on Motivational Interviewing to prevent AEP and, thus, prevent FASD. Three of the studies have been completed: CHOICES Feasibility Study; Project CHOICES randomized control trial (RCT); and Project Balance RCT. Two additional studies are ongoing and are funded by NIAAA: EARLY RCT and Mechanisms of Action of CHOICES process-outcomes research. Additionally, CDC is funding a CHOICES Dissemination Project that is in the pilot testing phase. The report also summarizes the progress of research on intervening with pregnant women to reduce alcohol use, highlighting three recent studies. Results of these studies show that (i) pregnant women with the highest levels of alcohol use reduce their drinking most after a BI that includes their partners; (ii) BIs delivered by nonmedical professionals in a community setting can lead to increased abstinence and improved outcomes; and (iii) dramatic decreases in newborn morbidity and mortality can be realized by consistent maternal screening and BI in an HMO setting. These results are consistent with those of many other studies conducted over the past 25 years, especially over the past 10 years, demonstrating that it is possible to screen, intervene, and improve pregnant womens birth outcomes by reducing their prenatal use of alcohol. Reaching out to Special Populations: Intervening with Women with or At-Risk of HIV Infection Womens use of alcohol (particularly binge drinking) increases risky sexual behaviors (e.g., multiple sex partners, unprotected intercourse, receptive anal sex) and the likelihood of acquiring sexually transmitted diseases (STDs). Among women, binge drinking is perhaps the single most risky behavior related to HIV infection. For women who are HIV positive, use of alcohol negatively affects their initiation of and adherence to highly active antiretroviral therapy (HAART), thereby increasing the risk of mother-to-child transmission, which otherwise is largely preventable with appropriate HIV care. Alcohol use also compromises immune function and increases depression, which independently decreases both the womens adherence to HAART and her immune function. Pregnant womens access to care for HIV/AIDS and substance abuse during pregnancy and postpartum is variable. Although research on integrated interventions for alcohol misuse and HIV is in its infancy, there is early evidence that such interventions may be feasible and effective in community settings. Studies target prevention, as well as treatment, and the combination of HIV infection and alcohol use suggests two strategies: to integrate HIV interventions into alcohol and other drug treatment settings, or to integrate alcohol interventions into HIV care settings. More well-controlled research is needed to evaluate promising interventions in substance abuse treatment settings and HIV care settings. Measuring the Cost-Effectiveness of Interventions for Substance Misuse among Women of Childbearing Age Most of the arguments about effectiveness and cost in preventing substance-exposed pregnancies have been resolved. The research shows that interventions can be effective and are more cost-effective (e.g., among adolescents) when implemented at earlier ages. Integrating the interventions with medical care is critical given that they are not a one-time magic bullet, but, rather, entail regular follow-up and aftercare. Moving towards a disease management model, such as that used with asthma, diabetes, and pain, would keep primary care physicians and services in the loop after treatment. Because most primary care clinics and chemical dependency programs are part of a larger system, the organizational aspects of their inclusion need to be considered when designing, developing, and evaluating interventions. Privacy issues also need to be addressed. Marketing the Message: Alcohol, Tobacco, and other Substance Use and Pregnancy Do Not Mix Marketing a health message is both strategic and operational. It begins with identifying the behavior or issue to change, followed by conducting consumer research, segmenting and selecting the audience, developing an integrated marketing plan, and integrating the effort into a comprehensive program. The next steps are monitoring the program, making midcourse revisions (keeping in mind that communications and marketing is not a static, finite process), and evaluating the impact. The main lesson learned over the years is that what we know worked then still works now. Specifically, it is known that a greater volume of advertising results in greater awareness of the product (brand) and is more likely to result in changes in attitude and behavior in the direction advocated; paid advertising is effective, and controlling where advertisements are placed is the best way to reach the intended audience with maximal effectiveness; and knowing ones audience and letting it say what the message should be (as was done in the CDC Sabemos campaign) is critical. Future Directions for Preventing Alcohol, Tobacco, and other Substance-Exposed Pregnancies: Framing an Action Agenda Substance abuse is a universal phenomenon affecting women of all cultures and economic backgrounds. It is also a transgenerational phenomenon influenced by complex historical, cultural, and socioeconomic factors. Trauma (physical, emotional, psychological) and violence are a large part of the problem of substance-exposed pregnancies that cannot be ignored, and comorbid psychological distress must be addressed. Given the complexity of the environment in which substance-exposed pregnancies occur, preventing and reducing these pregnancies will require the commitment of a community of partners (e.g., parents, peers, health care providers, policymakers, media) willing to plan and implement multi-level solutions. At the individual and program level, the evidence is clear that screening, assessment, and treatment work. At the community and societal level, the time is now for an effective health marketing campaign that will make the fact that alcohol, tobacco, and other substance use and pregnancy do not mix common knowledge. Of all the many important themes discussed over the course of the symposium, the need for government and community partners to be willing to work together over the long haul to prevent substance-exposed pregnancies is arguably the most important. The problem of substance-exposed pregnancies has a long and complicated history that involves every domain of community life, from law and social policy (e.g., enforcement of underage drinking laws; high density of alcohol and drug outlets in impoverished urban communities), to commerce and marketing (e.g., alcohol advertising targeting an increasingly young demographic; high volume packaging of alcohol products, such as 40 oz. bottles of beer), to health behaviors and services (e.g., interaction of environmental and intrapsychic factors in health decision-making; paucity of integrated primary care, mental health, and substance abuse treatment services). Solving the problem will require a long-term commitment from individuals and organizations in all of these sectors to conceptualize a cohesive community framework within which they may work together to prevent alcohol, tobacco, and other substance-exposed pregnancies and ensure a better quality of life for future generations. Deidra Roach, M.D. Work Group Leader ICCFAS Work Group on Women, Drinking, and Pregnancy Preventing Alcohol, Tobacco, and other Substance-exposed Pregnancies: A Community Affair Rockville, Maryland September 2324, 2008 MEETING PROCEEDINGS On September 23 and 24, 2008, the Work Group on Women, Drinking, and Pregnancy of the Interagency Coordinating Committee on Fetal Alcohol Syndrome (ICCFAS), the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the American Legacy Foundation, a nonprofit health foundation dedicated to preventing tobacco use, collaborated and hosted a symposium. The aim of the symposium was to explore best approaches to disseminating the message about the potential harm caused by risky drinking, tobacco, and other substance use during the childbearing years and, in particular, the importance of abstaining from any and all drinking and smoking during pregnancy. A joint objective of the symposium was to initiate a national effort to change the common perception that the use of alcohol and tobacco during pregnancy is safe. Approximately 103 addiction prevention and treatment professionals, health policymakers, health communications and marketing professionals, addiction researchers, community activists, Federal agency representatives, and others participated in the symposium. Twenty-two presentations were organized into seven general topic areas: Epidemiology and Impact of Prenatal Substance Use on Birth Outcomes in the U.S. Federal Agency Activities to Address Substance Misuse Among Women of Childbearing Age Intervening with Women in the Preconception Period and During Pregnancy Reaching Out to Special Populations Measuring the Cost-Effectiveness of Interventions for Substance Misuse Among Women of Childbearing Age Marketing the Message: Alcohol, Tobacco, and other Substance Use and Pregnancy Do Not Mix Future Directions for Preventing Alcohol, Tobacco, and other Substance-exposed Pregnancies: Framing an Action Agenda Welcome and Introductory Comments Deidra Roach, M.D., NIAAA, NIH; Leader, ICCFAS Women, Drinking, and Pregnancy Work Group Kenneth R. Warren, Ph.D., Deputy Director, NIAAA, NIH; ICCFAS Chairperson Dr. Roach welcomed the participants and thanked them for coming together as Federal and private partners to address a serious challenge facing the nation: The need to prevent alcohol, tobacco, and other substance-exposed pregnancies and to provide early intervention services to improve the lives of families already affected by prenatal substance exposure. Special mention was given to the American Legacy Foundation for its generous support and partnership in planning the meeting; to the members of the ICCFAS Work Group on Women, Drinking, and Pregnancy; and especially to Dr. Faye Calhoun, former Deputy Director, NIAAA. Dr. Warren also welcomed the participants and thanked the American Legacy Foundation and others who contributed to organizing the meeting. He noted that, in 1978, NIAAA issued a brochure entitled Alcohol and Your Unborn Babythe first publication issued by the U.S. Government to communicate the message that drinking and pregnancy do not mix. Still today, more than 30 years later, more than 30 percent of pregnant women drink alcohol at some time during pregnancy (Ethen et al. 2009). Why? Maybe its because society, the media, and some medical professionals continue to communicate mixed messages about alcohol use during pregnancy. Dr. Warren challenged the participants to explore best approaches to improving delivery of the message that abstaining from use of alcohol, tobacco, and other substances during pregnancy is vitally important and to improving access to high-quality treatment services for women with alcohol, tobacco, and other substance use disorders. Historical Background Kenneth R. Warren, Ph.D., Deputy Director, NIAAA, NIH; ICCFAS Chairperson Dr. Warren summarized the history of research on alcohol and pregnancy, the chronology of Federal advisories on this topic, and the challenges ahead for preventing substance-exposed pregnancies and intervening with families affected by prenatal substance exposure. Understanding Alcohol and Pregnancy: A History. From the end of prohibition to the 1970s, alcohol was considered safe to consume at any time during pregnancy and at any dose. Today alcohol is a known teratogen (an agent capable of causing physical birth defects including cognitive-behavioral and emotional deficits) and considered to be the most common preventable known cause of mental retardation and learning disabilities in the world. In fact, the recognition of alcohol as a teratogen led to the development of behavioral teratology as a field of study. Before the 20th century, alcohol was commonly used as medicine, but by the mid-20th century it had only two uses in medical practice: It was administered as standard treatment for ethylene glycol and methanol poisoning and for threatened premature labor. Not until the 1970s would studies emerge to challenge the latter use and, even then, physicians continued to use alcohol to treat threatened premature labor until the 1980s. In a March 1971 article in the American Journal of Obstetrics and Gynecology, Horiguchi challenged physicians use of alcohol in pregnant women based on the results of primate studies, noting that this treatment was not only ineffective but also dangerous. The controversy over whether the use of an alcohol drip during pregnancy was effective and safe continued until the 1980s. Meanwhile, recognition that alcohol was a teratogen grew during the 1970s. In 1970, observations on the failure to thrive among offspring of alcoholic mothers were described by Ulleland in a printed abstract and presentation at the Annual Meeting of the American Pediatric Society-Society for Pediatric Research in Atlantic City (Ulleland et al. 1970), and three years later Jones and Smith (1973) introduced the term fetal alcohol syndrome (FAS). Their description of the physical and behavioral characteristics of FAS firmly established alcohol as a teratogen. Following these reports, NIAAA supported research in the early 1970s to validate the existence of FAS. Those animal and epidemiological studies led to the recognition of FAS, alcohol-related birth defects (ARBD), and alcohol-related neurodevelopmental disorder (ARND). While the specific mechanisms by which alcohol causes some of these adverse effects remain unclear, research conducted in the 1980s demonstrated that even low doses of alcohol have adverse effects on the fetus. Even earlier evidence points to alcohol as a risk factor in pregnancy. In the French medical literature, Rouquette wrote a thesis in 1957 associating maternal use of alcohol with certain clinical features in children, and in 1968 Lemoine described a new syndrome he observed in children whose mothers had used alcohol during pregnancy. These studies failed to attract medical attention anywhere in the world including the U.S. Federal Advisories. In 1977, NIAAA organized the first international conference on FAS. The recommendations from this conference led to the first U.S. Government advisory on drinking during pregnancy (DHEW 1977). The advisory was written from a conservation perspective and states that alcohol use during pregnancy was safe until proven dangerous, and advised pregnant women who drink alcohol to consume no more than 2 alcoholic drinks a day. In May 1981, the U.S. Surgeon General issued a new advisory that basically urged pregnant women not to drink alcohol (DHHS 1981). In February 2005, the U.S. Surgeon General reissued its health advisory based on the recommendations of the National Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effects ( HYPERLINK "http://www.surgeongeneral.gov/pressreleases/sg02222005.html" http://www.surgeongeneral.gov/pressreleases/sg02222005.html ). This advisory, which is still in place today, recommends that a pregnant woman should not drink alcohol during pregnancy; that a woman who is considering becoming pregnant should abstain from alcohol; and that health professionals should routinely ascertain whether pregnant women and women who are considering becoming pregnant are consuming alcohol and advise them not to drink alcoholic beverages. The U.S. is one of only two countries (the other being France) that require a warning label regarding drinking and pregnancy on alcoholic beverages. In the 20012002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), more than 5 percent of U.S. women of childbearing age met Diagnostic and Statistics Manual IV (DSM IV) criteria for alcohol abuse or dependence (Grant et al. 2004; Hasin and Grant 2004). Binge drinking is becoming more common among women of childbearing age, and estimates of risky drinking (i.e., drinking 3 or more drinks a day) range as high as 30 percent (Nayak and Kaskutas 2004). While the prevalence of prior-month drinking by U.S. pregnant women in the U.S. declined from the 1980s to the 1990s (Serdula et al. 1991; Ebrahim et al. 1999), it remains at an unacceptably high level. Results from national telephone surveys indicate that about one in eight pregnant women reported alcohol use in the 30 days preceding the interview. These numbers did not change substantially throughout the 1990s and early 2000s (Floyd and Sidhu 2004). In a recent publication, Ethen and colleagues (2009) reported that more than 30 percent of women who delivered live infants between 1997 and 2002 consumed alcohol at some time during pregnancy. Those results are consistent with clinical data from smaller samples. These alarming trends persist despite public health warnings and the growing social stigma associated with drinking during pregnancy, and point to a need for urgent action to reduce substance use in this vulnerable population. Remaining Challenges. A major issue today is that it is still not widely understood and accepted that abstinence from alcohol during pregnancy is the safest course of action. No level of alcohol consumption has been demonstrated to be safe during pregnancy. The U.S. media, society, and some physicians continue to convey mixed messages about alcohol use and pregnancy, such as, If done in moderation, alcohol use during pregnancy is safe or It is fine to have a glass of wine after the first trimester. These messages have been challenged publicly by the American College of Obstetrics and Gynecology (ACOG) and the March of Dimes, which emphasize that women should not drink at all during pregnancy. The challenges for today are to explore the best approaches to improve delivery of the message of the importance of abstaining from all drinking and smoking during pregnancy and to improve delivery systems for the treatment of women with alcohol use disorders. The Evidence Substance Use among Women of Childbearing Age Prevalence of Substance Use among Women of Childbearing Age R. Louise Floyd, R.N., D.S.N., Centers for Disease Control and Prevention Dr. Floyd presented an overview of national evidence on the prevalence and outcomes of alcohol, tobacco, and illicit drug use among women of childbearing age. Drawing on these data, she suggested opportunities to modify preconception risk factors related to health knowledge, behavior and attitudes, and access to health care. In the U. S., alcohol, tobacco, and illicit drug use are among the leading causes of morbidity and mortality and among the 10 leading health indicators cited in Healthy People 2010. Maternal use of these substances during early pregnancy (46 weeks gestation) exposes the fetus to a range of adverse outcomes. While most women discontinue drinking after learning that they are pregnant, approximately one-half of all pregnancies are unplanned, and most women do not know they are pregnant until 46 weeks after conception. This means that, even among women who are inclined and able to discontinue drinking after learning they are pregnant, a high percentage of pregnancies are alcohol exposed. Thus, while it is known that approximately 15 percent of women continue to drink after learning they are pregnant, the actual total number of alcohol-exposed pregnancies is probably significantly higher than this number suggests. One of the strongest predictors of substance use during pregnancy is substance use before pregnancy (Day et al. 1993; Floyd et al. 1999). Prevalence Data and Outcomes. The report of the 2006 National Survey of Drug Use and Health (NSDUH), conducted by the Substance Abuse and Mental Health Services Administration (SAMHSA 2007), presents the most recent data available on alcohol, tobacco, and illicit substance use in women of childbearing age (1544 years). Among pregnant women, the data show that approximately 12 percent reported use of alcohol during the previous month; approximately 3 percent reported binge drinking; more than 16 percent reported tobacco use; and 4 percent reported use of illicit drugs. Each of these practices may result in adverse outcomes for both mothers and infants. A review of the literature indicates that use of alcohol, tobacco, and certain illicit drugs during pregnancy may independently result in similar adverse birth outcomes (Floyd et al. 2008). When women use multiple substances, as is increasingly common in todays culture of polydrug use, they place themselves and their infants in double or triple jeopardy. The independent effects of alcohol use include spontaneous abortion, growth restriction, birth defects, alcohol-related neurodevelopmental disorder (ARND), FAS, and other fetal alcohol spectrum disorders (FASD). Adverse birth outcomes associated with cigarette smoking include intrauterine growth retardation, prematurity, low birth weight, and Sudden Infant Death Syndrome (SIDS), while some illicit drugs are known to cause placental abruption, premature rupture of membranes, prematurity, and perinatal death. Alcohol is the substance most commonly abused by women of childbearing age. Use patterns are distributed regionally, but not uniformly, throughout the country. For example, Centers for Disease Control and Prevention (CDC) data from the Behavioral Risk Factor Surveillance System (BRFSS) show that binge drinking among women ages 1844 appears to be more prevalent in colder climates, such as the mid-west and western states and some northeastern states. Wisconsin has the highest proportion of binge drinking among women of childbearing age in the U.S. In 2005, the rate was 18.3 percent or approximately 1 in 5. Delaware was close at 16 percent. Lowest rates are found in Utah (6.4 percent) and southern states, such as Alabama and Georgia, at 7.5 percent. BRFSS data from 1991 through 2005 show that the percentage of non-pregnant women ages 1844 who either used alcohol or engaged in binge drinking was steady over this 15-year period at 53 percent and 12 percent, respectively. The percentage for pregnant women of the same age who reported any alcohol use fluctuated, but was approximately the same in 2005 as in 1991 (12 percent), whereas the percentage who reported binge drinking increased since 1991 (to approximately 2 percent). The different data for pregnant women who reported binge drinking in the BRFSS and NSDUH studies (2 percent versus 3 percent, respectively) may reflect the different age groups covered. The BRFSS surveys women 1844 years of age while the NSDUH surveys women 1544 years. Modifiable Preconception Risk Factors. Binge drinking and smoking are two preconception risk factors that can contribute to poor pregnancy outcomes and may be modifiable. Using BRFSS data from 2006, CDC researchers calculated the prevalence of these risk factors and three others (obesity, diabetes, frequent mental distress) among non-pregnant women of childbearing age. Approximately 49 percent of women had no risk factor, 33 percent had one risk factor, and 17.5 percent had two or more risk factors. The data on drinking and smoking show disparities in prevalence rates among women of childbearing age by race/ethnicity, education, and access to care and point to opportunities for targeting preconception health care to groups of non-pregnant women who are the most vulnerable. The groups with the highest prevalence of binge drinking (approximately 18 percent) were white and other (i.e., Hawaiians, Pacific Islanders, and individuals indicating mixed race); whereas, those with the highest prevalence of current smoking were Native American (approximately 35 percent) and white (approximately 24 percent) women. The groups with the highest prevalence of two or more of the five risk factors considered (e.g., alcohol and tobacco use, which are highly correlated) were Native American women (approximately 29 percent), other women (approximately 23 percent), and white women (approximately 19 percent). Analysis of multiple risk factors by level of education provided the clearest evidence of disparities. In stepwise fashion, the prevalence of two or more risk factors was highest (approximately 27 percent) for women with less than a high school education; lower for those with high school; lower still for those with some college; and lowest (approximately 10 percent) for women with college or more education. Among women who reported having accessible care, approximately 12 percent (i.e., one in eight) reported concurrent use of alcohol (> 12 drinks in the past year) and cigarette smoking [National Health Interview Survey (NHIS) 20032005 data]. The Challenge. Despite the information, screening tools, and interventions available to the public, no substantial progress has been made to reduce hazardous alcohol use among women of childbearing age. The data show that substance use is prevalent among preconception women; most, but not all, women decrease substance use when they learn they are pregnant (Ebrahim et al. 1999; Floyd et al. 1999); vulnerable groups can be identified and targeted; and many women at risk are seen by providers who could either intervene directly or refer them to appropriate treatment. Development of better strategies to achieve a greater public health impact will require a careful review of the lessons learned from both research and real world community experience. Women and Substance Abuse: Risk Factors and Health Impacts Carrie Randall, Ph.D., Medical University of South Carolina Dr. Randall discussed the unique risk factors and health impacts of substance misuse among women, the shorter interval between initiation of substance use and onset of substance dependence and substance-related health problems (a phenomenon referred to as telescoping) in women versus men, and the effects of various commonly abused substances on birth outcomes. She noted that non-pregnancy-related research on women and substance abuse did not generally begin until the early 1990s, when NIH mandated that women must be included in all NIH-funded research, and that there is still a dearth of information related to women and substance abuse compared to that available for men. Unique Risk Factors. Recent studies show that women and men share a general risk factor for substance abuse: Family history. Women also have certain unique risk factors for developing alcohol and drug use disorders. These unique risk factors include alcohol or drug use by others (e.g., family members, partners), a history of abuse or violence, and comorbid psychiatric disorders (Blum et al. 1998). An understanding of these unique risk factors is important for addressing womens issues in recovery and designing effective treatments. Women who are victims of abuse or violence are especially prone to developing addictions as a way to cope with their situation. A recent study indicates that women of childbearing age who have a history of being physically abused are more likely to drink hazardously on weekends, 1.8 times more likely to drink within 90 days of their first prenatal visit, 2.5 times more likely to drink after they thought they were pregnant, and more likely to use drugs before and during pregnancy (Martin et al. 2003; Alvanzo and Svikis 2008). Data from the National Comorbidity Survey of 19901992 show that women, compared with men, have a higher incidence of mood and anxiety disorders (Kessler et al. 1994). These disorders often predate womens abuse of substances, which, for some women, may be a coping mechanism. Telescoping. Women progress faster, compared with men, from first substance use to regular and dependent use and first treatment, a phenomenon referred to as telescoping. A 2004 study showed that women progressed faster from regular use of opioids, cannabis, and alcohol to dependence on these substances than did men (Hernandez-Avila et al. 2004). The telescoped development of alcoholism in women reported in this study was consistent with Dr. Randalls 1999 research on landmark events in alcoholism, which demonstrated that, although men begin drinking at an earlier age than women, women progress faster from drinking regularly to having their first problems with alcohol and from there to losing control (onset of dependence) and having their worst problems with alcohol. In addition, she found that men and women experience their worst problems with alcohol at approximately the same age (Randall et al. 1999). One reason for this telescoped development of alcohol problems in women is that alcohol is especially toxic to womens bodies, causing damage to many of their organs at lower doses than those that cause damage in men. Organs that may be adversely affected by alcohol include, but are not limited to, the liver, brain, heart, skeletal muscle, and pancreas. The blood alcohol concentration produced by a given amount of alcohol is higher for women than for men of the same size because of certain physiological factors (e.g., amount of fatty tissue, body water, alcohol dehydrogenase) that increase the tissue exposure to alcohol in women. Also, the greater organ toxicity in women may result in part from alcohol-induced elevated levels of corticosterone and from estrogen-induced increased sensitivity of the gastrointestinal system to endotoxins. Health Factors. Although women generally use smaller quantities of substances for fewer years compared with men, they have, on average, more medical, psychiatric, and social consequences. Studies show, for example, that drinking increases womens risk of liver disease, neurotoxicity, breast cancer, and hypertension at lower levels of alcohol consumption than those associated with these conditions in men. In addition, compared with men, women have a higher risk of developing cirrhosis of the liver at near-equal alcohol consumption levels, and alcoholic women experience greater reductions in brain tissue than do alcoholic men (Hommer et al. 2001). Compared with women who are nondrinkers, women who consume 2.55 drinks a day have a 40 percent higher incidence of breast cancer (and the risk increases as the number of drinks increases), and women who drink more than three drinks a day have almost a threefold increase in risk of hypertension. Of particular interest are the possible gynecological and obstetric consequences of alcohol abuse. These include amenorrhea due to heavy drinking and resulting unpredictable cycling and increased risk of unplanned pregnancies; high rates of miscarriage; unintended exposure of the fetus to alcohol during the first trimester; increased risk of FAS and fetal alcohol effects (FAE); and other poor pregnancy outcomes. Pregnancy Concerns. In addition to having unique risk factors and sequelae of substance abuse, women have additional unique issues in relation to pregnancy outcomes and fetal growth and development. Screening with good biomarkers is essential during pregnancy because, regardless of the substance being abused, pregnant women are at increased risk of both poor pregnancy outcomes and poor fetal outcomes. Such adverse birth outcomes may include prematurity, fetal growth retardation, low birth weight, and other conditions that require treatment in a neonatal intensive care unit (NICU). Most drugs of abuse easily cross the placenta and reach the fetus. Alcohol, which crosses the placenta more easily than other commonly abused substances, is a classic (physical) teratogen resulting in birth defects, as documented in animal studies. Along with certain other substances (e.g., cocaine, marijuana, nicotine), it is also recognized as a behavioral teratogen. All of these substances are vasoactive and cause spasms of the umbilical cord, potentially reducing the flow of blood, oxygen, and nutrients to the fetus. Patterns of exposure are especially important determinants of fetal outcomes, with critical factors including dose and timing. Binge drinking and binge use of other substances results in higher-than-usual levels of a substance crossing the placenta and is particularly harmful to the developing fetus. Fetal exposure to alcohol and other substances during the first three trimesters may negatively affect craniofacial, brain, and neuronal development. As shown in some studies of twins, genetic factors may render some women particularly vulnerable to adverse pregnancy outcomes. In any case, substances of abuse may interact with nutritional variables (e.g., protein and calorie intake) to yield adverse birth outcomes, and pregnant women who use multiple substances risk exposing themselves and their unborn children to complicated drug interactions. Prenatal Exposure: Effects of Commonly Used Substances Claire D. Coles, Ph.D., Emory University, School of Medicine Dr. Coles presented her multifactor model that centers on the fetus and mother and encompasses the prenatal environment of substance use, the primary and secondary outcomes of this use, and the postnatal environment. She elaborated on the behavioral and developmental problems observed in children of women who abuse substances, and she encouraged attention to the enormous number of children already affected. Single Factor Model. Exposure to alcohol, tobacco, and other commonly used substances results in a continuum of effects on reproductive and developmental outcomes, from impaired fertility to birth defects and behavioral problems, as well as to potentially normal outcomes. Much of the research to date has relied on a single-factor teratogenic model that focuses on individual substances to understand the possible mechanisms of their effects on the fetus and mother during pregnancy. The intent is to isolate effects and to use this knowledge to develop prevention and treatment strategies. While research on alcohol, tobacco, and a range of illicit drugs is elucidating their independent effects, the emerging picture of substance abuse is complicated by womens exposure to substances used to cut drugs, such as methamphetamines, and their combined use of illicit and licit drugs, such as caffeine, aspirin, antihistamines, and prescribed medications (e.g., barbiturates and tranquilizers). Most women who use alcohol and drugs in pregnancy use more than one drug, with cigarettes and alcohol being most common, followed in order by marijuana and prescription drugs, stimulants (e.g., cocaine, methamphetamines), and opiates. This use of multiple substances is further complicated by genetic variations in effects and by postnatal environmental factors. Multifactor Model. The more realistic picture of substance abuse is a complex interaction of multiple risk factors with multiple outcomes. A multifactor model is therefore both more accurate and more truthful. Proposed by Dr. Coles in 1995, this interactive model includes the prenatal environment (e.g., social factors, legal issues, prenatal care, substance use/abuse, maternal characteristics, genetics) and its effects on the fetus and mother; primary outcomes (e.g., reduced fertility, fetal wastage, preterm birth, birth defects, growth retardation); secondary developmental and medical effects; and the postnatal environment (e.g., maternal health status, legal issues, social factors, nutrition, substance use/abuse, education, social services). At the core of this model is the fetus, who may experience adverse physical, behavioral, and developmental effects related to maternal substance use. Behavioral and Developmental Effects in Children. Children and adolescents who have been exposed to alcohol and drugs prenatally exhibit many different developmental and behavioral problems. For example, prenatal exposure to alcohol is associated with cognitive, neurodevelopmental, and academic deficits in children. One study of a cohort of children who were followed into their mid-twenties associated mothers use of alcohol during pregnancy with lasting effects on the childrens brain development (e.g., reduced myelinization in the corpus callosum) and cognitive and academic performance (e.g., decreased memory, inability to sustain a learning effort). Studies of children with FAS show, among other abnormalities, reductions in the volume of white matter in the occipital parietal region and functional deficits in visual attention compared with controls. In general, children with FAS have lower IQs and deficits in executive functioning, motor skills, and visual-spatial processing, all of which affect academic achievement, particularly in mathematics. In addition, they have problems with adaptive behavior, social behavior, and communication and a higher incidence of mental health issues and behavioral disorders. In contrast to alcohol, prenatal exposure to cocaine is not associated with reduced growth or deficits in cognitive and mental development. Studies show, however, that it may affect childrens psychophysiology (e.g., their response to stress, ability to sustain attention, etc.), and that these effects may interact with environmental factors to produce particular patterns of developmental psychopathology. A longitudinal study of 8-year-old children exposed prenatally to cocaine and other substances showed effects on behavioral and emotional functioning (e.g., externalizing, internalizing, sex problems, etc.). Studies of maternal smoking show an association with deficits in auditory habituation and language development in toddlers and preschoolers. Combined with a familys socioeconomic status (SES) and environment, maternal smoking may cause an early deficit in auditory processing that links with deficits in phonemic and phonetic processing that emerge in middle childhood to impede childrens language development and reading. Studies of auditory evoked potentials in babies of mothers who smoked during pregnancy show a significant relationship between prenatal cigarette use and latent conduction of the auditory nerve signal in the brain stem of the infants. Cholinergic pathways may be involved in this relationship, as nicotine excites acetylcholine receptors in the auditory pathways. Several behavioral studies point to an association between prenatal exposure to smoking and conduct problems and disruptive behavior in youth and later adult criminality and hospitalization for substance abuse. Panel Discussion on At-Risk Populations, and Treatment and Preventions Facilitator: Carrie Randall, Ph.D., Medical University of South Carolina The participants addressed specific aspects of two broad topics: 1) at-risk populations; and 2) treatment and prevention. At-Risk Populations Women with FASD. Mr. Dan Dubovsky noted that a number of women who abuse alcohol and/or other substances may themselves have an FASD and may need treatment approaches specifically tailored to them. Dr. Floyd suggested that broad interventions [e.g., Parent-Child Assistance Programs (PCAP)] that include life skills and others that are tailored to the specific needs of affected individuals may be helpful. Client-centered approaches to intervening with affected women and families have been recently evaluated by CDC with promising results. Depression and Drinking. Dr. Mary OConnor called attention to the large percentage of pregnant women who are drinking, have moderate-to-severe depression, and do not quit despite their physicians recommendations. Referring to a study of pregnant, primarily Latina women participating in the Women, Infants, and Children (WIC) program, she emphasized that Latina women are a particularly vulnerable group. Among the English-speaking women in this study, approximately 20 percent of current drinkers drank before learning they were pregnant, and, of this group, 60 percent continued to drink after being urged to stop (OConnor and Whaley 2003). In addition, although the percentage of Spanish-speaking women who drank was low, those who did drink tended to be heavy drinkers. Dr. Randall noted the comorbidity of depression and alcohol misuse and the need to offer women alternative coping skills. Genetic Variations. Ms. Margo Singer mentioned that women in treatment programs often say that they drank during pregnancy and that their babies are fine. Dr. Coles responded by noting that research on the epigenetics of alcoholism to identify women at highest risk for giving birth to alcohol-affected children is a cutting-edge issue in child development and holds great promise. Dr. Warren reminded the group that alcohol is an independent risk factor, just as the genetic profile of the mother-infant dyad may be, and the message must be: It is not safe to drink at all during pregnancy. Just because one womans child may not be affected at a given time does not mean that the child will not be affected at another time during the pregnancy or that the child of another woman, who drinks the same amount at the same time in her pregnancy, will not be affected. Dr. Randall agreed and noted that, in a womens clinic setting where she teaches a course on FAS and FASD, husbands are often the most accepting of the total abstinence message. Ms. Kathy Mitchell added that women in treatment often report childrens cognitive issues but do not relate these to their drinking during pregnancy. Insofar as the highest risk populations often end up in treatment, she suggested that addiction treatment providers should routinely screen their patients children and question women about their pregnancies in greater detail to increase identification and treatment of substance-exposed children. Autism and Substance Abuse. Ms. Patricia Senner asked whether researchers have considered a possible connection between substance abuse and Aspergers syndrome or autism, given that many homeless youth coming to shelters have these disorders. Dr. Coles said that no relationship between FAS and autism has been found, and that the behavior of children with FAS is very different from that of children with autism. Treatment and Prevention Interconception Care. Ms. Jeanne Mahoney noted that many states have family planning waivers that extend womens health care to 36 months beyond the immediate postpartum period. Such extended health coverage could be used for follow-up treatment of women who abused substances during pregnancy. Applauding this idea, Dr. Floyd suggested that agencies could coordinate development and dissemination of a uniform package of materials and messages about the risks and treatment of substance abuse among women of childbearing age. Research on Biomarkers. Dr. Randall cited the need for biomarkers within a medical model that would be attractive and useful to physicians who could, when alerted by a laboratory test result, question pregnant women in greater depth about possible substance misuse. Dr. Warren noted that clinical research on biomarkers is promising. Researchers in Europe have recently published results comparing pregnant womens reports of alcohol use with objective data from tests using non-oxidative metabolites of ethanol (e.g., ethyl glucuronide and ethyl sulfate in urine and hair) as primary biomarkers. Interestingly, the results show that a large number of women who deny substance use have positive biomarkers. Dr. Warren anticipated that this promising research in Europe will inform U.S. research planning efforts, and that proteomics and metabolomics will generate more advanced biomarkers. Patient Histories. Dr. Grace Chang emphasized the importance of clinicians obtaining good patient histories in a non-judgmental, no-contingency environment using validated screening tools. Dr. OConnor agreed, saying that obtaining patient histories is essential for universal prevention and should be routine practice. Reaching Physicians. Drs. OConnor and Randall noted that physicians are far more likely to counsel women about smoking than they are about alcohol use. A major challenge is to encourage primary care physicians to inquire about alcohol use and to provide them with information on ways to intervene. Dr. Erin Frey commented that physicians need to learn about the disease of addiction and how to screen women for this disease in the course of their education and training. Dr. OConnor mentioned that physicians are more likely to counsel or refer pregnant women who are drinking if they can bill for their time. Adding the International Classification of Diseases (ICD) codes for substance abuse to marketing messages targeting physicians could be an effective incentive. Some Federal Agency Activities on Identification of At-Risk Alcohol and other Substance Use and Intervening With Women of Childbearing Age Centers for Disease Control and Prevention (CDC) R. Louise Floyd, R.N., D.S.N., Centers for Disease Control and Prevention Dr. Floyd highlighted key activities of CDCs Fetal Alcohol Syndrome Prevention Team. Functioning within the National Center on Birth Defects and Developmental Disabilities (NCBDDD), the team has launched a variety of effective training, intervention, prevention, and health services initiatives. FASD Regional Training Centers (RTCs). In 2002, CDC established four centers with funding through fiscal year (FY) 2008. The Centers have trained more than 26,000 medical and allied health students and practitioners in 23 states and Puerto Rico. A summary can be found in the American Journal of Health Education (FASD RTCC 2007). Following a re-competition in 2008, CDC awarded funding to five centers for 3 years to replicate and build on prior efforts and to implement and evaluate competency-based FASD medical curricula. CDCs Competency-Based Curriculum Development Guide for FASD can be found at  HYPERLINK "http://www.cdc.gov/ncbddd/FAS/curriculum/index.htm" www.cdc.gov/ncbddd/FAS/curriculum/index.htm . Health Provider Surveys. CDC is assessing the knowledge, attitudes, and practice behaviors of health providers. Two surveys have been completed: One of obstetricians and gynecologists (OB/GYNs) (Diekman et al. 2000) and one of pediatricians (Gahagan et al. 2006). Two follow-up surveys of OB/GYNs (submitted for publication) and psychiatrists (manuscript in progress) have been completed recently, with publication expected in 2009 or 2010. Interventions with Children with FASD. In 2001, CDC funded five grantees to develop and test evidence-based interventions for FASD. Each grantee focused on a different functional area (e.g., social communications, executive functioning, compliance, etc.), and all reported positive results, with four reporting significant differences between treatment and control groups (Bertrand 2009). In 2004, CDC funded follow-up translational research to determine the effectiveness of the interventions in community-based settings. These studies are in their final year. CHOICES Dissemination Project. CDC is partnering with private and public organizations to package, market, and disseminate CHOICES, the proven motivational intervention to reduce the risk of alcohol-exposed pregnancies among non-pregnant women who drink. The effort includes development of a training curriculum, counselor manual, and workbook; design of a Web site and other on-line resources; development of adaptations for special populations; and evaluation. In June 2008, the original Project CHOICES study won the Charles C. Shepard Science Award, which is sponsored by CDC and honors excellence in science at CDC during the previous year. In September 2008, CDC funded a grantee for 3 years to bundle CHOICES with a facilitated referral for smoking cessation for women who smoke. (For more information on CHOICES, see the summary of Dr. Ingersolls presentation.) National Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effect (NTFFAS/FAE, the Task Force). Ms. Mary Kate Weber, the designated federal authority for the Task Force, described this initiative, which was federally mandated from 2000 to 2007 and coordinated by NCBDDD. The Task Force, which ended in October 2007, was initially established to foster coordination and to advise on FAS research, programs, and surveillance and, in so doing, to better meet the general needs of populations affected by FASD. Among its accomplishments, the Task Force developed and published a national agenda for FAS and other prenatal alcohol-related effects (NTFFAS/FAE 2002), FAS Guidelines for Referral and Diagnosis (in 2004), access at  HYPERLINK "http://www.cdc.gov/ncbddd/FAS" www.cdc.gov/ncbddd/FAS , and the U.S. Surgeon Generals Advisory on Alcohol Use in Pregnancy (in 2005), access at  HYPERLINK "http://www.surgeongeneral.gov/pressreleases/sg02222005.html" http://www.surgeongeneral.gov/pressreleases/sg02222005.html. The Task Force also completed two additional publications for release and dissemination in late 2008: Reducing Alcohol-Exposed Pregnancies, and A Call to Action: Advancing Essential Services and Research on Fetal Alcohol Spectrum Disorders ( HYPERLINK "http://www.cdc.gov/ncbddd/FAS" www.cdc.gov/ncbddd/FAS ). The first report focuses on prevention and includes a review of evidence-based prevention strategies, 10 recommendations based on the evidence, and future directions for prevention research. The recommendations include, for example, increasing alcohol screening and brief intervention services; assessing evidence-based intervention strategies tested in other than traditional clinical settings; improving education and training for health care providers; and increasing access to appropriate treatment services for women with substance use disorders. The second report is aimed at policymakers, advocacy groups, and other interested stakeholders. It seeks to ensure that essential services are provided for individuals with FASD and their families and to promote continued research on promising interventions. Substance Abuse and Mental Health Services Administration (SAMHSA) Patricia Getty, Ph.D., Center for Substance Abuse Prevention, SAMHSA Dr. Getty described the goals and activities of the SAMHSA FASD Center for Excellence. She noted that research on FASD is growing and that two exciting directions are: 1) How to implement programs effectively; and 2) how to continue to effectively translate research findings for all populations concerned or affected by FASD. In 2000, SAMHSA awarded a contract to establish the FASD Center for Excellence, as mandated by the Childrens Health Act of 2000. Subsequently, in 2004, SAMSHA funded 35 subcontractors for 3 years to integrate FASD prevention and treatment interventions into state and community substance abuse programs and juvenile court programs. Following Congressional reauthorization of the Center for another 5 years, in 2008, SAMSHA awarded a follow-up contract to support specific activities of 23 subcontractors. Reflecting the 2000 Congressional mandate, the aims of the Center are to: Identify best practices and expand evidence-based prevention and treatment services for pregnant and postpartum women, individuals with FASD, and other populations affected by FASD (e.g., families, service systems); Identify gaps and trends in FASD research, synthesize current research findings, and develop appropriate materials for health and social service professionals, communities, states, and tribal organizations; and Act as a resource center for individuals and organizations seeking information on FASD. Specific activities are noted below. Best Practices and Evidence-Based Prevention and Services. To promote the translation of science to services, in 20052008, the Center supported a thorough review of the literature on FASD programs. This effort resulted in identification of eight programs that address the prevention of FASD and include curriculum training and evaluation components. The Center has nominated all of the programs for inclusion in the SAMHSA National Registry of Evidence-based Programs and Practices, which will be published in 2009. To expand the base of science-based, effective programs, the Center has identified other programs that are promising but need support to move from concept to demonstration of effectiveness. The Center is encouraging these programs to apply to the SAMHSA Services to Science Academy for evaluation support. The Academy continuously monitors the field and welcomes applications for support from programs deemed to be promising after critical review by its panel of health services experts. The Center anticipates publishing a report of its review of the field, which will detail emerging epidemiological trends and promising prevention and treatment practices. Gaps, Trends, and MaterialsTraining and Technical Assistance. The Center provides extensive training and technical assistance on issues related to FASD, with the goal of promoting the development of collaborative and comprehensive systems of care. The Center has developed curricula and partnerships to translate research findings to existing programs. This effort involves working closely with the subcontractors to uniformly implement training and follow-up. To date, the Center has supported more than 400 training activities in 44 states and the District of Columbia. The training has included the use of Screening and Brief Intervention, Referral for Treatment (SBIRT) to foster consistent screening and referral of women who abuse substances and Project CHOICES to promote contraception and prevention of relapse to substance misuse. Materials from these programs became available in Spanish on October 1, 2008. In addition, the Center is expanding its scope to include the Native American Initiative and will begin collaborating with SAMHSAs substance abuse treatment and mental health centers to develop a series of Treatment Improvement Protocols (TIP) on FASD targeting Native American communities. Information Resources on FASD. The Center maintains a Web site featuring information, news, and events related to FASD ( HYPERLINK "http://www.fasdcenter.samhsa.gov" www.fasdcenter.samhsa.gov ). The database of more than 9,000 multimedia publications is fully searchable and updated regularly. The average Web site visit is 37 minutes and products are downloaded approximately 20,000 times per month. In addition to the Web site, the Center maintains an Information Resource Center (1-800-STOPFAS) that is responding to more than 400 telephone calls each year. The many inquiries coming from consumers and professionals and the increasing number from university and graduate students are indicative of an expanding interest in FASD. Health Resources and Services Administration (HRSA) John McGovern, M.G.A., Maternal and Child Health Bureau, HRSA Mr. McGovern described the Health Resources and Services Administrations (HRSA) three activities on FASD: 1) Healthy Start grants; 2) a best practices contract; and 3) a cooperative agreement for training and technical assistance. Healthy Start Grants. HRSAs Maternal and Child Health Bureau (MCHB) supports 99 Healthy Start grants to prevent infant mortality. All grantees incorporate screening for alcohol use and education about FASD into their prenatal and postpartum care and education programs. In summer 2008, they participated in a webcast on FASD. Best-Practices Contract. MCHB also supports a contract to review the Bureaus grants and contracts in alcohol, substance abuse, and perinatal depression to identify best practices. The report on best practices was recently completed in 2008, and the best practices identified will be incorporated into HRSAs future grant announcements. Cooperative Agreement. In 2004, Congress earmarked monies for HRSAs Bureau of Primary Health (BPH) to target FASD. Subsequently, in 2005, the monies were directed to MCHB. The funds were awarded under a cooperative agreement, first with the National Organization on Fetal Alcohol Syndrome (NOFAS) and then with Childrens Research Triangle, with NOFAS as a subcontractor. The funds support training and technical assistance for health care providers in HRSA-supported Community Health Centers (CHCs) and Maternal and Child Health (MCH) sites. The aim is to improve clinical practice in three areas: 1) Prevention of FASD; 2) screening and identification of pregnant and intrapartum women for alcohol use and of children for evidence of FASD; and 3) support of individuals with FASD to ensure access to early and appropriate interventions. In partnership with other organizations and state agencies, the grantees have provided training and technical assistance in more than 10 states. Activities for 20082009 include focus groups of men and women of reproductive age to increase awareness of FASD and to provide guidance on designing a prevention campaign to disseminate the message that no amount of alcohol is safe to drink during pregnancy. A range of products is available and includes curricula for physicians, nurses, social workers, and substance abuse treatment providers; a handbook entitled FASD Across the Span of Childhood; Web-based technical assistance ( HYPERLINK "http://www.childstudy.org/FASDtraining" www.childstudy.org/FASDtraining), including narrated PowerPoint presentations; and prevention-oriented brochures and posters. Outcomes for 2008 are positive. More than 350 providers received training in prevention, screening, and brief intervention, and the grantees conducted both a case control study and an assessment of screening rates. The case control study of physicians participating in an FASD curriculum showed a positive significant difference between their pre- and post-test scores as compared to a control group who did not receive training in the FASD curriculum. The screening rates of all eligible women at follow-up improved from 65 percent to 85 percent, and 90 percent of pregnant women with a positive screen received a brief intervention. The totals of the 2008 screening results from all the CHCs and MCH sites were as follows: 18 percent to 25 percent of intrapartum women had a positive screen for alcohol use and almost 30 percent of approximately 2,500 pregnant women also had a positive screen for alcohol use. In addition, 3.4 percent of approximately 2,800 children, birth to 5 years of age, had three or more abnormal features associated with FASD. This was a screening done just in general pediatric offices so focused only on physical features of alcohol exposure. The five features included in the pediatric screening were: philtrum, upper lip, height below 3rd percentile, weight below 3rd percentile, and head circumference below 3rd percentile. Pediatricians and pediatric nurse practitioners successfully used the lip/philtrum guide but were not able to evaluate palpebral fissure size on physical exam. National Institute on Alcohol Abuse and Alcoholism (NIAAA) Susan E. Maier, Ph.D., Division of Metabolism and Health Effects, NIAAA, NIH Dr. Maier presented a brief overview and update of the NIAAA research portfolio, projects, and messages pertaining specifically to pregnancy, women, and alcohol. Noting that the research findings on alcohol-exposed pregnancy continue to point to potentially devastating outcomes, she suggested that perhaps its time to change the message. NIAAA is the lead agency for funding scientific research on alcohol disorders and health and has a federal mandate to disseminate research findings to all citizens who can make use of them. The FASD research portfolio is diverse and accounts for more than 8 percent of the NIAAA annual budget. Research programs address the prevention and treatment of high-risk women, etiology of FAS (e.g., maternal risk factors for adverse outcomes), and potential therapeutic interventions for FASD (including exercise, nutrition, and cognitive therapies). NIAAA has established a Fetal Alcohol Spectrum Disorders Working Group to identify research gaps for funding and to propose research initiatives to address them. Pregnancy, Women, and Alcohol. Within the NIAAA portfolio, a number of projects are specific to this topic. They range, for example, from research on screening tools to studies of the interaction of alcohol with human immunodeficiency virus (HIV); the relationship between prenatal alcohol exposure and SIDS (Sudden Infant Death Syndrome) and stillbirth; comorbidities of depression and other mental health disorders and alcohol; the interactive effects of nutrition and alcohol exposure on birth outcomes; and research on policies to prevent FASD. The research is being conducted in the U.S. and internationally (e.g., in Australia, Europe, Russia, South Africa). Among the larger NIAAA-sponsored projects focused on alcohol-exposed pregnancies are the Prenatal Alcohol and SIDS and Stillbirth (PASS) Network and the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD). PASS is a collaborative effort with the National Institute of Child Health and Human Development (NICHD) to develop community-linked studies to investigate the role and interrelationship of genetic factors, prenatal alcohol exposure, and other environmental factors in the risk for SIDS and other adverse pregnancy outcomes such as stillbirth and FAS. The effort includes a prospective study of 12,000 pregnant women from clinical sites in the U.S. and South Africa. Researchers are looking at many dependent measures to elucidate the broad epidemiology of drinking and adverse pregnancy outcomes and to examine, in embedded studies, brain pathology and fetal and neonatal physiology. The CIFASD initiative consists of a set of 10 interrelated projects intended to inform the development of effective interventions and treatment approaches for FASD. The approach is multidisciplinary and includes linked research cores providing centralized services such as data coordination and analysis, clinical projects involving pregnant women who drink and children with prenatal alcohol exposure, and basic science studies. The primary aim of the Consortium is to translate basic research in animals (e.g., correlations between blood alcohol concentrations and neurologic deficits; therapeutic levels of choline supplementation) to the clinical setting with improved therapeutic interventions for women and children. DNA research to elucidate the epigenetic effects of alcohol use in women and children is also being funded under this initiative. For more information on PASS, see  HYPERLINK "http://www.nichd.nih.gov/research/supported/pass.cfm" www.nichd.nih.gov/research/supported/ pass.cfm. Additional information on CIFASD is available at  HYPERLINK "http://www.cifasd.org" www.cifasd.org. Framing a New Message. The findings from research supported by NIAAA and others are clear. Women of childbearing age drink alcohol in significant numbers, and they drink in binge-like patterns, often before they know they are pregnant (i.e., very early in the first trimester, a time that is critical for fetal development) and even after they know they are pregnant. The international data reported for binge drinking during pregnancy are astonishing: In Moscow, 20 percent at the time of conception (Chambers et al. 2006); in South Africa, up to 87 percent in some communities (May et al. 2005); and in Switzerland, 2 percent (Lemola and Grob 2007). This binge-like alcohol consumption often leads to risky behaviors and is more harmful to an embryo or fetus than is a continuous pattern of drinking. It must be emphasized, however, that the extent of adverse effects on offspring, from mild to severe, is not predictable based on maternal alcohol consumption, at any level and at any stage of embryonic or fetal development. Yet, in Italy, 69 percent of women with a child with FASD reported drinking during the first trimester (Ceccanti et al. 2007), and, in Switzerland, 30 percent of screened pregnant women reported continuing to drink at least once per month (Lemola and Grob 2007). Whereas the research findings on the adverse effects of prenatal alcohol exposure remain the same, womens behavior is not changing. Clearly it is time to re-examine the message and the delivery of the message. Intervention Research Intervening in the Preconception Period Karen Ingersoll, Ph.D., University of Virginia Dr. Ingersoll presented highlights and conclusions from a series of studies aimed at preventing alcohol-exposed pregnancies (AEP) by intervening in the preconception period. The studies sought to capture non-pregnant, drinking women who were at risk for pregnancy but not actively planning pregnancy nor seeking treatment for drinking and to test interventions based on Motivational Interviewing to prevent AEP and, thus, prevent FASD. Three of the studies have been completed: CHOICES Feasibility Study; Project CHOICES randomized control trial (RCT); and Project Balance RCT. The first two were funded by CDC and the last funded by a cooperative agreement between CDC, the American Association of Medical Colleges, and the investigators. Two additional studies are ongoing and are funded by NIAAA: EARLY RCT and Mechanisms of Action of CHOICES process-outcomes research. Additionally, CDC is funding a CHOICES Dissemination Project that is in the pilot testing phase. (See the summary of Dr. Floyds presentation above.) The four intervention studies have yielded five overall conclusions, as follows: 1) The risk of an alcohol-exposed pregnancy can be lessened with behavioral motivational interventions, even among women not seeking change. 2) Single and four-session interventions have efficacy. 3) Achieving changes in contraceptive behavior is easier than achieving changes in drinking, but perhaps only in settings where contraception is accessible and inexpensive. Additionally, many women do change their drinking but not necessarily below risk levels. 4) A greater dose of effective interventions and/or provision of necessary resources for contraception may be required in higher-risk women to achieve prevention of alcohol-exposed pregnancy. 5) Motivational approaches to combined alcohol/drug use and risky health behaviors, including poor contraceptive habits among women, merit further study and dissemination. Highlights of the first four studies are summarized below. CHOICES Feasibility Study. This study, which became the model for subsequent studies, enrolled 201 women from six settings in three states. Following a lengthy assessment at baseline, all women received the intervention, which consisted of motivational interviews targeting two behaviors: Risky drinking and ineffective contraception. Over 3 months, the women attended four semi-structured counseling sessions and one gynecological or family planning visit. Follow-up data were obtained at 3 and 6 months, and pre-post comparisons were made. The three outcome variables were: Ineffective contraception, risky drinking (more than four drinks on any one day or more than seven drinks per week), and risk of alcohol-exposed pregnancy due to ineffective contraception and risky drinking. The intervention had promising results, with a majority of women who changed behavior achieving both effective contraception and low-risk drinking. More women achieved effective contraception than low-risk drinking, suggesting that the level of alcohol use may predict outcome. The study showed that a dual-focus, motivational, preconception approach to reducing risk of alcohol-exposed pregnancy is feasible and could have an impact on public health. The results and the pre-post evidence provided the justification for a larger phase II RCT to establish efficacy. Project CHOICES RCT. This trial was a multi-site collaborative project involving CDC and three university research centers. Out of 4,626 women assessed for eligibility, 827 were randomized to an intervention or control group and were followed for 3 and 9 months after the intervention period. The control group received only information and referrals. The results were similar to those obtained in the feasibility pre-post comparison: After 9 months, more than two-thirds of the intervention group was not at risk for alcohol-exposed pregnancy and approximately one-half were using effective contraception and drinking in a non-risky manner. At follow-up, the women in both groups (control and intervention) had a reduced risk of alcohol-exposed pregnancy, but those in the intervention group were twice as likely to not be at risk as those in the control group, and more of them changed both behaviors. The RCT showed that the CHOICES intervention is efficacious, and the outcome findings are robust across diverse population groups and settings, suggesting that CHOICES could reduce the rate of alcohol-exposed pregnancy on a national level if widely disseminated. The findings served as a springboard for the CHOICES Dissemination Project. (For more information on the CHOICES Dissemination Project see Dr. Floyds presentation in the Federal Agency Activities section.) Project Balance RCT. This study, conducted at Virginia Commonwealth University, focused on preventing pregnancy and risk drinking in college women. It included focus groups, an epidemiological survey screen, and an RCT that adapted the CHOICES model to college women who do not perceive their drinking or contraceptive behaviors as problematic and may have little readiness or motivation to change their behaviors. The epidemiological survey showed that 63 percent of the women drank five or more drinks on some days during the prior month, and 21 percent used ineffective birth control during the prior month, yielding 17 percent at risk for alcohol-exposed pregnancy. The intervention targeted binge drinking and ineffective contraception and involved a single, 3.54 hour motivational session with a trained counselor, one gynecological visit, feedback on risk behavior and personality variables, and briefer follow-ups at 1 and 4 months that could be mailed or e-mailed. The rates of change were similar to those in the Project CHOICES RCT, which involved community participants. Both groups (control and intervention) showed large reductions in risk for alcohol-exposed pregnancy, although the intervention group benefited more than the control group, with a significant decrease in binge drinking and an increase in effective contraception. The results persisted at 4 months, except for some reversal to binge drinking. The study pointed out the high rate of risky drinking and unprotected sex among college women, and it showed that a one-session motivational intervention targeting dual behaviors with brief follow-ups is feasible and effective in this more educated group with greater motivation to avoid pregnancy and good access to contraception through student health services. EARLY RCT. In this ongoing NIAAA-funded study of community and college women, researchers are testing single-session interventions that are modifications of the successful Project CHOICES and Project Balance interventions to increase their efficiency and portability. The EARLY RCT involves 258 women who are randomly assigned to one of three groups: 1) The EARLY intervention group, which receives a 1 hour personalized motivational interview, feedback and counseling with FASD information and a 10-minute video; 2) the EARLY video group, which receives a one-session video and debriefing; and 3) the EARLY control group, which receives information and a list of local resources. All are assessed at baseline and are followed up at 3 and 6 months. The 81 participants enrolled thus far were all at risk for alcohol-exposed pregnancy at baseline because of risky drinking and ineffective contraception. The women had a mean age of 28 years and an educational level of almost 14 years; 51 percent smoked; the mean number of drinks was 15 drinks a week; all engaged in risky drinking (at least one binge in 90 days); and 32 percent were alcohol dependent. They used contraception effectively in approximately 38 percent of intercourse episodes, and almost 16 percent did not use any contraception during the past 90 days. Preliminary results for the 81 participants at 3 months show a significant increase in effective contraception and a significant decrease in number of binge drinking episodes across all groups. However, the mean number of drinks per drinking day did not change, and 76.5 percent of the participants remained at risk for AEP because of intermittent contraception and binge drinking. This may be an artifact of a newer, more conservative manner of evaluating contraception effectiveness, and the study team is currently developing methods to use both the strict and previous methods to extend comparability across studies. Alternatively, these preliminary results suggest that the single-session, lower-intensity intervention designed for community women may have less impact than a similar intervention for college women, who tend to be highly motivated to avoid pregnancy. Intervening with Pregnant Women Grace Chang, M.D., M.P.H., Brigham and Womens Hospital and Harvard Medical School Dr. Chang summarized the progress of research on intervening with pregnant women to reduce alcohol use, highlighting three recent studies. She noted that the FAS field faces several challenges in its work: The stigmatization of women who consume alcohol; the failure of health care providers to recognize the extent of prenatal drinking; concerns about social and other sanctions against prenatal substance use; reluctance to conduct RCTs involving pregnant women; and design issues related to small sample sizes and narrowly defined populations (e.g., women with severe alcohol problems). Studies conducted over the past 25 years, especially over the past 10 years, prove that it is possible to screen, intervene, and improve pregnant womens birth outcomes by reducing their prenatal use of alcohol. Further, screening and intervention can be done in diverse settings [e.g., hospitals, community clinics, health maintenance organizations (HMOs)] with diverse populations (e.g., different SESs and demographics). The brief intervention (BI), in particular, is very promising and can be used effectively by diverse practitioners, including physicians, nurses, nutritionists, and substance abuse specialists. In a recent article, Bailey and Sokol (2008) document the evidence and provide a helpful script for responding to pregnant womens questions about alcohol use. Early Intervention Studies. Two decades ago, researchers showed that counseling pregnant women about alcohol use could have an impact. At Boston City Hospital, for example, counseling resulted in 33 out of 49 problem drinkers reducing their alcohol intake before the third trimester (Rosett et al. 1983). In Europe, intensive counseling of 85 pregnant alcoholics throughout gestation resulted in 65 percent of the women reducing their drinking by at least half; however, 42 offspring were born with features consistent with FAS (Halmesmaki 1988). Transformative Developments. Research on interventions in pregnant women leapt forward with the development of improved screening instruments suitable for pregnant women (e.g. T-ACE, TWEAK, and the Audit-C) and BIs that could be used by different clinicians in a variety of settings to reduce drinking in nondependent drinkers. The T-ACE is among those recommended by ACOG and consists of screening questions that are familiar to physicians. The four core components of BI (i.e., assessment and feedback; goal setting and contracting; behavioral modification; and written materials) are similar to the strategies used in other interventions (e.g., FRAMES: feedback; responsibility; advice; menu; empathy; self-efficacy). Screening and BIThree Recent Studies. Several major findings have emerged from three recent and different studies using screening and BI. The results show that (i) pregnant women with the highest levels of alcohol use reduce their drinking most after a BI that includes their partners; (ii) BIs delivered by nonmedical professionals in a community setting can lead to increased abstinence and improved outcomes; and (iii) dramatic decreases in newborn morbidity and mortality can be realized by consistent maternal screening and BI in an HMO setting. Specific details of the three studies are as follows. The first study is an RCT of women receiving obstetric care and their partners at Brigham & Womens Hospital in Boston, MA (Chang et al. 2005). The women were well educated and at a median of 11.5 weeks gestation; less than 20 percent were considered abstinent (averaging 1.5 drinks per episode); and 30 percent drank two or more drinks per episode. Those at highest risk had a higher level of education, were more tempted to drink in social settings, and had more previous alcohol use. The intervention consisted of a single-session BI given by a physician or nurse. The results showed that both the assessment and intervention groups reduced alcohol use; the BI was most effective for women who drank more and had partners who participated; and women who selected abstinence rather than reduction as a goal had better results. Other important findings were that medical records documenting the standard exam identified only 11 percent of women at risk for alcohol use in this study, and that drinking before pregnancy is highly predictive of alcohol use during pregnancy, a finding that is consistent with results from a number studies conducted over recent years. The second study is the Public Health Foundation Enterprises (PHFE)-WIC Study, an RCT conducted in 12 selected PHFE-WIC centers (OConnor and Whaley 2007). Of approximately 5,000 women screened for the study, 345 were randomized to two groups administered by a nutritionist: Assessment only and assessment followed by BI. The women were screened at every monthly prenatal visit. The results showed that women in both groups reduced their drinking; BI was more effective than assessment only (i.e., women in the BI group were five times more likely to report abstinence); and newborns of women in the BI group, especially women who drank heavily, had more positive outcomes (e.g., greater birth weights and birth lengths, less fetal mortality). The third study is an Early Start program at Kaiser Permanente Northern California (KPNC), a naturalistic study conducted in the setting of a comprehensive treatment program for prenatal substance abuse (Goler et al. 2008). The study consisted of universal screening for alcohol and drug use; urine toxicology screening with consent; and BI and referral to OB/GYN treatment. Of approximately 50,000 women screened, approximately 3,400 were assigned to three groups: Screened/assessed/treated (SAT), screened/assessed (SA), and screened positive only (S). The remaining women, who screened negative, served as a comparison group. The researchers examined 10 neonatal and maternal outcomes, and their findings were impressive. Integration of substance abuse treatment with prenatal visits was associated with a positive effect on maternal and newborn health. The SAT group had outcomes similar to those for the comparison group; the SA group had rates between the SAT and S group; and the S group had significantly worse outcomes than did the SAT groupa twofold increase in preterm delivery; a six-fold increase in placental abruption; and a sixteen-fold increase in intrauterine fetal demise. Intervening with Women with/or At-Risk for HIV Infection Mary E. McCaul, Ph.D., Johns Hopkins University School of Medicine Dr. McCaul described the characteristics and care of women who are of childbearing age, use alcohol, and have or are at risk for HIV infection. She noted that the reasons for studying this group of women are many, and that research on interventions for pregnant women who are HIV positive and use alcohol is limited. Dr. McCaul reviewed the evidence regarding the role of alcohol in HIV risk behavior and summarized some of the literature on interventions. Alcohol and HIV Risk Behavior. In the U.S., the estimated number and proportion of AIDS cases among female adults and adolescents escalated over the past 20 years, reaching almost 30 percent of all AIDS cases currently, such that women are now the fastest growing segment of people living with AIDS in the country. The distribution of cases by race and ethnicity is disproportionate to the distribution of racial and ethnic groups in the U.S. population. Among HIV-positive women, 66 percent are African American and 15 percent are Hispanic, although these groups comprise 13 percent and 11 percent, respectively, of all women in the U.S. High-risk heterosexual contact is the source of HIV infection for 71 percent of female adults and adolescents with AIDS (80 percent for those ages 2024), and sex with men of unspecified or unknown risk accounts for almost 60 percent of the cases. HIV/AIDS, Alcohol, and Pregnancy. Recent reports suggest that HIV-positive women have lower rates of pregnancy than do HIV-negative women. However, most women are infected with HIV during their childbearing years. Womens use of alcohol (particularly binge drinking) increases risky sexual behaviors (e.g., multiple sex partners, unprotected intercourse, receptive anal sex) and the likelihood of acquiring sexually transmitted diseases (STDs). Among women, binge drinking is perhaps the single most risky behavior related to HIV infection. For women who are HIV positive, use of alcohol negatively affects their initiation of and adherence to highly active antiretroviral therapy (HAART), thereby increasing the risk of mother-to-child transmission, which otherwise is largely preventable with appropriate HIV care. Alcohol use also compromises immune function and increases depression, which independently decreases both the womens adherence to HAART and her immune function. Pregnant womens access to care for HIV/AIDS and substance abuse during pregnancy and postpartum is variable, as shown by retrospective analysis of Medicaid claims data on pregnant, HIV-infected substance abusers. After delivery, women were less likely to receive antiretroviral therapy but more likely to receive treatment for substance abuse. Receipt of obstetrical care was positively associated with receipt of antiretroviral therapy and substance abuse services, although African American women were least likely to receive these. Interventions. Most available intervention data come from demonstration projects without comparison groups, and randomized clinical trials are few. Studies target prevention as well as treatment, and the combination of HIV infection and alcohol use suggests two strategies: to integrate HIV interventions into alcohol and other drug treatment settings, or to integrate alcohol interventions into HIV care settings. More well-controlled research is needed to evaluate promising interventions in substance abuse treatment settings and HIV care settings. Interventions for the former might include HIV risk reduction counseling and HIV treatment services such as HAART. Interventions for the latter might include alcohol screening, assessment, and referral; brief motivational interventions for alcohol and HIV risk reduction; and comprehensive, integrated care models. Although research on integrated interventions for alcohol misuse and HIV is in its infancy, there is early evidence that such interventions may be feasible and effective in community settings. For example, a prevention RCT designed to build safer sex skills (SSB) among women with HIV and/or STDs in a community drug treatment program resulted in 29 percent fewer unprotected sex occasions for women in the SSB intervention group compared with women who only received education about HIV. In another study, patients coming to a methadone treatment clinic or mobile health care van received directly administered HAART, a treatment that resulted in improved HIV indicators and led to an RCT that is now replicating the results. Demonstration projects conducted in HIV care settings suggest that a multidisciplinary team approach can lead to improved access to substance abuse screening, assessment, and referral for at-risk individuals (e.g., homeless, unemployed, with poor HIV outcomes). In a South African study conducted in an HIV care setting, a one-time, 60-minute BI to build behavioral skills in HIV and alcohol risk reduction, compared with two 20-minute HIV education sessions, was successful in three areas: Increased condom use, reduced use of alcohol in sexual contexts, and reduced expectancies that alcohol use would enhance sexual experiences. Brief motivational interviewing also has been used successfully to reduce alcohol use among needle-exchange clients. In a current RCT, Dr. McCaul and colleagues are assessing a BI to reduce hazardous drinking and improve HIV-related outcomes among non-pregnant, HIV-positive women in an HIV care setting. To examine differences in mental health and quality-of-life status, the comparison group comprises HIV-positive women who are not hazardous drinkers. Thus far, the hazardous drinkers are more likely to report current problems with mood and activities of daily living, which increases their involvement in HIV risk behaviors, including unprotected sex. Assessments are being done at baseline and at 3, 6, and 12 months. Reaching out to Special Populations The Mississippi Experience Debbie Long, Mississippi FASD Prevention Project Ms. Long described the Project CHOICES program at Pine Belt Mental Health Care Resources in Hattiesburg, Mississippi. Initiated approximately 8 months ago, the 4-year program serves women ages 1844 who are at risk for having an alcohol-exposed pregnancy. Pine Belt is a nonprofit mental health center serving individuals who have severe mental illness, are elderly or developmentally disabled, or abuse alcohol or drugs. The CHOICES program is incorporated into the continuum of care that the center provides in the two largest counties (of nine) served by the center. The planning for CHOICES has been completed and screening and intervention began approximately 2 months ago. All women ages 1844 and their children who access the center in the two counties are screened for eligibility for CHOICES. Women are also screened at two inpatient residential facilities and an outpatient facility for alcohol and drug treatment. The intervention consists of four motivational interview sessions, while two other grants support complementary contraception education and HIV risk reduction counseling. Among women seen with severe mental illness, 72 percent have co-occurring alcohol and drug issues. The focus of motivational interviewing for these women is to increase their awareness of contraceptive use and decrease alcohol-related accidents. Discussion. Ms. Singer noted the association between mental illness and FASD, estimating that approximately 60 percent of children with FASD in Alaska require mental health treatment. Referring to CDCs CHOICES Dissemination Project, Dr. Floyd asked Ms. Long to comment on the Centers need for technical assistance in implementing the program. Ms. Long mentioned that CDCs training was informative and positive; in fact, the Center needs more individuals trained in CHOICES, as well as regular technical assistance with program updates. Ms. Singer, who directs a CHOICES program at three sites in New York City, stated that ongoing technical assistance is critical, especially because of the turnover of counselors in community mental health centers. She noted also that many women served by these centers have very low literacy levels and the CHOICES workbook, manual, and other materials may need to be modified for this population. An Urban California Experience Lee Kaskutas, Ph.D., University of California, Berkeley Presented by Constance Weisner, Ph.D., University of California, San Francisco Dr. Weisner described a vessels intervention based on findings from the Determining Effective Educational Resources (DEER) Project funded by NIAAA. The purpose of the vessels intervention was to open a dialogue with pregnant women about drinking during pregnancy. The challenge when working with women who drink is threefold: To recognize that some will not abstain while pregnant; To help them understand how much they drink; and To communicate the benefits of reduced drinking while not giving them permission to drink. The DEER Project. This pilot epidemiology study addressed womens knowledge, attitudes, and drinking behavior during pregnancy. Focusing on inner-city African American and American Indian pregnant women recruited at WIC and prenatal clinics, the study included focus groups, surveys, and an approach to measuring womens actual alcohol consumption that included the use of clear, marked glasses and photos that could be used to estimate the size of a womans typical drink. The findings indicated that, although almost all of the women had seen warnings and knew about the abstinence during pregnancy message, the messages were ineffective for this group. Further, the women had many misconceptions about drinking during pregnancy, and almost half of them overestimated the size of a standard drink and therefore were consuming more standard drinks than they thought they were. The Vessels Intervention. Applying the DEER research methodology, this larger RCT involved approximately 900 insured, urban, and suburban pregnant women who accessed 20 Kaiser Permanente Early Start clinics. The clinics were randomized to two interventions: The vessels intervention and the usual care intervention (which strongly encouraged abstinence but did not include education and dialogue). Framed in terms of wanting a healthy baby, the intervention included use of the measured vessels and photos to help women better understand how much they drink; dialogue about whether abstaining is a realistic goal for the present; and an educational component. The women received education about the comparability in size and alcohol content of standard drinks; i.e., spirits, table and fortified wine, wine coolers, regular beer, and malt liquor. They also received specific advice on how to reduce their alcohol intake, such as: Know your triggers. Dont associate with heavy drinkers. Dilute with water/ice. Sip and eat. Dont drink alone. Comparison of the results from the vessels intervention and usual care intervention showed no significant differences in outcomes for mothers and infants and in mothers drinking at the third trimester follow-up interview. However, few women participated in the follow-up, and those in the vessels intervention may have reported their drinking more accurately. Questions remain (e.g., regarding long-term effects of the vessels intervention), and replication of the RCT in an inner-city population is desirable. Reactions to the vessels intervention were positive. Clinicians said it was time-efficient (lasting 2025 minutes), focused, interactive, and allowed for individualized discussions. Patients expressed surprise about the actual amounts they were drinking and asked whether their husbands could participate. The Cheyenne River and Turtle Mountain Chippewa Reservation Experience Sherlynn Herrera, Reclaiming the Sacred Trust Project Renee Parker, Strong Beginnings Project (Zoongii Majiitawin Project) Ms. Herrera and Ms. Parker conveyed important perspectives on alcohol use among Native American women of childbearing age. Both serve as site managers for the FAS Epidemiology Research Center (FASER), University of New Mexico. Ms. Herrera covers the Cheyenne River Sioux Reservation, South Dakota, where approximately 16,400 people reside in 19 communities (including 4 municipalities) across a 5,400 square mile area. Ms. Parker covers the Turtle Mountain Band Reservation of Chippewa Indians, North Dakota, where a similar number of people are crowded into 144 square miles. Despite the differences between the sites, many case management issues are the same. In these communities, health providers are few, and the limited health services are often personalized and linked to ancillary services. Each reservation has only one case manager (Ms. Herrera and Ms. Parker, respectively), one nurse in maternal and child health, and several community health representatives. All are overwhelmed trying to meet clients needs. Case managers do outreach; make home visits; transport clients; and provide education, screening, assessment, intervention, motivation, and referral services. They travel the reservation constantly to network with and engage clients one-on-one and in groups at clinics, schools, job sites, correctional institutions, and health fairs, which attract hundreds of residents. Most clients are self-referred but reluctant to seek help, and months of encouragement may be needed to entice them to access the few services available. Transportation to and from services is a significant problem and complicates any effort to screen, educate, and follow up. A case managers ability to listen, assess, and make referrals and to understand the difficulty of making behavioral changes is critical. Often the case manager is the only support a woman in need has on the reservation. Womens needs are closely linked to family concerns, and interventions for them must be targeted to the family. Many are in a fog, overwhelmed with a multitude of interrelated problems that often include addictions with coexisting mental health disorders. Alcohol and drug abuse are major problems that often affect multiple family members. Many of the problems among these Native American tribes are related to historical trauma, poverty, and lack of resources or programs designed to track women with addictions and other barriers. These problems are often associated with unresolved trauma from the past, physical and sexual abuse, and the many social problems related to poverty (e.g., high unemployment, lack of transportation, poor roads and other infrastructure, sparse community amenities). Approximately 32 percent of Native Americans live below the U.S. poverty level. Shame is an integral part of womens drinking and is difficult for them to overcome, even as they strive to improve the lives of their babies and families. On both reservations, with FASER support, the case managers offer screening, assessment, and 6-month follow-ups, and clients come voluntarily. Prenatal and WIC clinics are important points of entry into the health care system for women. At these clinics, use of fetal anatomic models has proven to be an effective way to educate women about the developing fetus and to relate this information to nutrition, exercise, smoking, and drug and alcohol use. Women and others (e.g., high school teachers and students) who have heard case managers presentations on alcohol use and pregnancy are very receptive and surprised that they have not heard this information before. Health Services Delivery and Marketing Measuring the Cost-Effectiveness of Interventions in the Health Care System: Making the Business Case Constance Weisner, Ph.D., University of California, San Francisco Dr. Weisner outlined the fundamentals of working with the health care system to build a business case for supporting and implementing effective interventions to prevent substance-exposed pregnancies. To make a business case means establishing the need for effective interventions and determining the cost impact of those interventions, linking the interventions to a larger model of care, and obtaining buy-in from all stakeholders who could promote or block implementation. Achieving parity for addiction treatment and other mental health disorders in health insurance is, of course, a major related issue. Drawing on her research experience at Kaiser Permanente Northern California, Dr. Weisner highlighted three questions to answer in making the business case: How do alcohol problems overlap with other medical and mental health concerns? What is the effectiveness and cost impact of treatment? Is moving toward a disease management model the best business case? She presented data to address each of these questions and summarized the implications of the answers. Overlapping Health Concerns. Women who misuse substances have overlapping health concerns at any age. Analysis of an aggregate of 800 women from two NIAAA-supported studies showed that 59 percent of the women were dependent on alcohol and other substances, mostly marijuana, stimulants, and cocaine. Across the lifespan, the severity of individual health problems varies. Assessments using the Addiction Severity Index showed, for example, that the severity of alcohol problems increased with age, while the severity of drug problems decreased, and the severity of psychiatric and medical conditions remained about the same. As health concerns change at different ages, the cost and effectiveness of treating these problems vary over time. Effectiveness and Cost of Treatment. The effects of treating alcohol-dependent individuals are strongly positive. In one study of public and private services, 57 percent of alcohol-dependent patients who received treatment were abstinent 1 year later, compared with 12 percent of those who did not receive treatment. Further, the outcomes for alcohol treatment compare favorably with those of other conditions treated. The average costs of treating chemical dependency over 5 years are higher for women than for men, but they decrease significantly in both the short and long term. Treatment of alcohol-dependent women is especially cost-wise given that they have a larger number of high-cost medical conditions than do alcohol-dependent men, as suggested by one prospective study of more than 400 adolescents with chemical dependency. Moreover, as women become abstinent, their family costs decrease. Breaking the chronicity of substance abuse reduces costs as well, because older persons use more medical services than do younger persons and older women more so than older men. A positive cost impact of treating chemical dependency in adolescents is not as clear. For the group of more than 400 adolescents mentioned above, their medical costs did not decrease in the year after treatment as did the costs for adults. However, because adolescents use multiple drugs, they have much more severe problems to treat than do adults. Girls, especially, have higher rates of use for all illicit drugs. They also have significantly higher rates of psychiatric comorbidities (e.g., depression, anxiety, conduct disorders) and of some HIV risk behaviors (e.g., injection drug use, no or inconsistent use of condoms). These factors result in higher treatment costs for girls than for boys, particularly in the average cost of primary care which, in girls, continues to rise over 5 years of treatment. Many have older boyfriends who introduce them to drugs, and most have parents who also have substance abuse problems. Approximately 15 percent of the girls in the study reported having a past pregnancy, and 5 years after intake into treatment, more than half had a child or were pregnant. Disease Management Model. The ideal system for managing the treatment of chemical dependence would begin with screening and BI. Adults and adolescents with mild to moderate problems would then be treated and monitored in primary care, referred to specialty care as needed, and returned to primary care for monitoring and continuing care. This system is feasible in either a divided or integrated health plan, and it requires the interactive involvement of primary care in providing initial and buy-back service. This interaction is less than optimal currently because of multiple structural challenges at the interface between primary care and specialty addiction treatment services that, with a few exceptions, have impeded the development of well-coordinated and integrated systems of care. Data on adolescents who have been treated for alcohol and drug use point to the need for primary care-based continuing care. One year after treatment, many of the adolescents in the study cited above were not abstinent: 59 percent were using alcohol, tobacco, or marijuana only and, of these, 65 percent were using alcohol only. The adolescents were followed for 5 years (to ages 1823), and the results at this time showed that one or more primary care visits per year was associated with higher rates of abstinence and remission, fewer HIV risk behaviors, readmission to treatment for those who had a relapse, and a mental health visit for those who had mental health symptoms at 1 year. Making the Case: The Implications. Most of the arguments about effectiveness and cost in preventing substance-exposed pregnancies have been resolved. The research shows that interventions can be effective and are more cost-effective (e.g., among adolescents) when implemented at earlier ages. Integrating the interventions with medical care is critical given that they are not a one-time magic bullet, but, rather, entail regular follow-up and aftercare. Moving towards a disease management model, such as that used with asthma, diabetes, and pain, would keep primary care physicians and services in the loop after treatment. Because most primary care clinics and chemical dependency programs are part of a larger system, the organizational aspects of their inclusion need to be considered when designing, developing, and evaluating interventions. Privacy issues also need to be addressed. Marketing the Message: Lessons Learned from the National Center for Health Marketing Lynn Sokler, National Center for Health Marketing, CDC Ms. Sokler presented a quick review of marketing science. She introduced the marketing mix of 4 Ps (product, price, place, and promotion) and focused on the segmentation and selection of audiences. Marketing a health message is both strategic and operational. It begins with identifying the behavior or issue to change, followed by conducting consumer research, segmenting and selecting the audience, developing an integrated marketing plan, and integrating the effort into a comprehensive program. The next steps are monitoring the program, making midcourse revisions (keeping in mind that communications and marketing is not a static, finite process), and evaluating the impact. Three main decision points are: 1) Pick and understand your customer (i.e., audience segment); 2) be clear about what you are trying to do (i.e., focus on what can be achieved); 3) build a compelling story (focused on must knows, not whats nice to know); and 4) promote the story, keeping in mind that, in order to change behavior, information must be communicated within the context of an intervention, not simply disseminated. Audience Segmentation. The most effective marketing programs do not reach out to everyone (as in public health). Rather, they target specific groups and segments with appropriate messages. For health interventions, three key questions are: 1) Who are the people at highest risk? 2) Who are the people most open to change? and 3) Who are the people/groups critical to the success of the program (e.g., intermediaries, peers, mass media, policymakers, managers)? Having a network of champions is always important. In developing an intervention for FAS, for example, the segmentation choices are many and may be defined by age, ethnicity, or SES; reproductive or pregnancy status; and nature or extent of substance abuse. Establishing the priority audience, that is, who is in the bulls eye, is critical to customizing a message. For example, an intervention that targets women ages 1844 is too broad. Consumer Styles 2007, a national survey of 12,000 adults, details the different lifestyles and interests of adults ages 1824, 2534, and 3544 and reveals clear trends in media usage at different ages. For example, the television channels watched most by adults ages 1824 are completely different from those watched most by those ages 3544, and whereas adults 1824 use the Internet most broadly, the largest percentage of adults using the Internet to look for health information (35 percent) is among those ages 2534. Marketing the Message. A key message to women in general is, of course, Alcohol and unprotected sex dont mix, but the message has to be conveyed differently to different groups. For a recent CDC campaign, for example, an initial audience of African American women ages 1844 who had low SES, drank weekly, and had unprotected sex was subsequently redefined because of the large differences in status, alcohol use, and attitudes and perceptions between women in their twenties and those in their thirties. The final audience comprised women ages 2535 who drank 713 drinks weekly. The CDC brochure developed for this group targeted two segments: Women ages 2529, who tended to be single, to binge drink and to engage in risky sex behaviors more often, and women ages 3035, who tended to have stable partners, children, and healthier lifestyles. An effective campaign depends on having a personal understanding of the women being targeted and hooking emotionally with them. Having a singular message is also important. For example, trying to address alcohol use disorders and possible co-occurring disorders in one message may be too complex and obscure the key message. Marketing the Message: Lessons Learned from the Office on Smoking and Health Judith Berkowitz, Ph.D., Centers for Disease Control and Prevention Michelle Johns, M.A., M.P.H., Centers for Disease Control and Prevention Dr. Berkowitz reviewed the strategies CDC has used over the past 100 years to prevent and control commercial tobacco use. She focused on the shifting paradigms and strategies for marketing the message about tobacco and health, and she noted recent media trends that need to be confronted. From 1900 to 2006, adult per capita cigarette consumption tracked with national events relating smoking to health outcomes. Consumption tended to rise steadily until 1964, when the first Surgeon General Report documented the causal link between tobacco use and lung cancer in men. With this publication and after each major policy initiative since then, per capita cigarette consumption has declined. Initiatives that have had an impact include the Fairness Doctrine for media messages, the federal excise tax on cigarettes, and the Master Settlement Agreement. In 2007, building on the lessons learned in tobacco control, nicotine and addiction, and communication and marketing, CDC published its Best Practices for Comprehensive Tobacco Control Programs2007, an evidence-based guide to help states plan and establish effective tobacco control programs. In tobacco control, as in prevention of substance-exposed pregnancies, an understanding of the competitive environment (e.g., tobacco control versus tobacco industry) is critical for determining where and how the most impact can be made. The climate of acceptability for an intervention will be affected by the public and target audiences perceptions of the problem, as well as the attention and focus of the media. Shifting Paradigms and Strategies. Over the years, marketing of the tobacco control message has advanced from health education to health communication and, more recently, health marketing; that is, to create consumer demand for a product and a relationship between the product and the consumer. In tobacco control, the marketing mix of the 4Ps, which reflect a sellers viewpoint, is complemented by SIVA (solution, information, value, access), which reflect a consumers viewpoint. Strategies of tobacco control have evolved through the decades. In relation to the 4Ps, during the 1960s and 1970s, the marketed product (i.e., message) was tobacco is bad and it causes cancer; the price (i.e., cost to consumers) was lung cancer and death; promotion emphasized scientific documents; and the place (i.e., where the consumer accesses the product) was wherever cigarettes were sold and health information was available. From the 1970s to the 1980s, the product was big tobacco is targeting our children; the price was excise taxes on cigarettes and social isolation; promotion consisted of counter-marketing techniques and media advertisements; and the place was wherever industry was marketing. During the 2000s, the product is smoking impacts all of us (i.e., secondhand smoke, clean air, smoke-free policies, and tobacco cessation); the price, in addition to social isolation, is the impact on public health; promotion is focused on branding the product; and the place is wherever smoke from commercial tobacco is. The new product strategy of defining the product as clean air and smokefree environments has given public health a competitive advantage over the tobacco industry and forced industry into a reactive position. Future Challenges. The main lesson learned over the years is that what we know worked then still works now. Specifically, it is known that a greater volume of advertising results in greater awareness of the product (brand) and is more likely to result in changes in attitude and behavior in the direction advocated; paid advertising is effective, and controlling where advertisements are placed is the best way to reach the intended audience with maximal effectiveness; and knowing ones audience and letting it say what the message should be (as was done in the CDC Sabemos campaign) is critical. For marketers, recent trends in the communication environment are especially challenging. Consumers have more control over the messages they receive, the media environment is fractured (e.g., viewers have access to a broader array of television channels), and consumers (especially the younger generation) multitask across different media at the same time. To confront these trends, marketers have to ensure that their messages (brands) are strong enough to stay visible, appropriately targeted to specific media users, and able to reach users by breaking through all the clutter. Marketing the Message: American Legacy Foundation Laura Hamasaka Jeffrey Costantino, M.B.A. Ms. Hamasaka and Mr. Costantino presented the aims and results of a specific media campaign launched by American Legacy Foundation in December 2001 in collaboration with American Cancer Society, Entertainment Industry Foundation, I Am Your Child Foundation, and Robert Wood Johnson Foundation. Entitled Great Start: Helping Pregnant Smokers Quit, this national campaign was the first in the U.S. to try to reduce smoking during pregnancy. The campaign communicated a unique and motivating cessation message through various media, materials, and stakeholders to a target population of primarily white, pregnant smokers ages 1524, who had low SES, a high school education or less, and a household income of $20,000 or less. Initial reactions to the name of the campaign and the Rupert logo used for the campaign were positive (i.e., the women connected with Rupert). The marketing phase, which included paid and donated advertising and use of the Quitline specifically for pregnant smokers, generated interest. Results after 3 years indicated that the following factors were associated with the womens success rates in quitting smoking: Attending more, rather than fewer, counseling sessions; not living with a smoker; living in a home where smoking is prohibited; and having social support, other forms of relaxation, and the support of a health care provider. The lessons learned from this campaign have been incorporated into the American Legacy Foundations EX campaign, a public health effort targeting the more than 70 percent of smokers who have been unable to quit. Details of the Great Start campaign are summarized in the discussion topics that follow. The Problem and the Opportunity. Smoking during pregnancy is a significant problem among women in their childbearing years, but it is also an opportunity to reach pregnant smokers with a unique and motivating cessation message. The prevalence of smoking among women ages 1824 is highest for those with a high school diploma or General Equivalency Diploma (GED), followed by those with less than a high school diploma, with rates similar to those in the general population. Among pregnant women, 11 to 22 percent smoke and, although 30 to 65 percent of pregnant smokers quit smoking while pregnant, 80 percent of those who stop return to smoking within a year after giving birth (Roske et al. 2006). Adverse birth outcomes associated with smoking during pregnancy include neonatal death, stillbirth, preterm delivery, low birth weight, and SIDS. Still, the barriers to quitting are daunting: Addiction; high stress levels; low awareness of the consequences; being in an environment where others smoke; perceiving a lack of tools and support to quit; and co-occurring abuse of other substances. Program Goals and Components. The goals of Great Start were to increase awareness of the risks of smoking during pregnancy; increase quit attempts before, during, and after pregnancy; increase providers willingness to refer pregnant women to cessation services; and support the women in their cessation efforts. The components included a media campaign (in television, radio, and print), educational materials to complement counseling sessions, a Web site for providers, and outreach to state departments of health. Understanding the Target Audience. Research conducted to clarify the target population for the campaign showed that, similar to young women who abuse alcohol, pregnant smokers usually have smoked since their early teens and engaged in other risky behaviors (e.g., risky sex, alcohol and drug use). In general, they have underperformed in school and have dysfunctional home lives and low self-esteem. Young motherhood is a common theme for their families and friends. Upon learning of their pregnancy, they initially react with disbelief and denial, emotional uncertainty, and high stress, which is a trigger for smoking. After delivery, they often find themselves alone or relying on their parents and with serious childcare and financial concerns. Though they seem old beyond their years, they are still young women with limited resources. Generally they do not view their child as a mistake. Understanding why the women smoke was important in designing the campaign. In discussions, the women mentioned a number of reasons, which included being addicted to smoking, relieving stress and feeling better able to survive day-to-day challenges, being surrounded by others who smoke, and needing a coping mechanism, a little luxury, some nurturing, or quiet time. Communication Guidelines and Response. From this research, the following guidelines emerged for communicating with pregnant women as well as others who smoke: Dont use dont; rather, empower and fire up. Give new facts. Dont judge. Avoid conveying the message that we know best. Dont intimidate with overly technical language. Praise and reward one step at a time. Be positive. Be different. The branding of the product message was based on these guidelines and led to the design of Rupert as the Great Start character who appeared in television ads, posters for physicians offices and clinics, and the invitation to call the Quitline. In their response to the message, the participants said it was inspiring, empowering, positive, new and fresh, fun, and not intimidating. The Quitline received approximately 10,000 calls, half of which came in January 2001, the month the campaign went national. Panel Discussion: the Role of the Media in Promoting and Reducing Tobacco Use Facilitator: Ellen Hutchins, Sc.D., M.S.W., M.P.H New NCI Report. Dr. Michele Bloch mentioned that the National Cancer Institute (NCI) supports fundamental research on tobacco use that includes studies of pregnancy, access, and policy issues. She noted the parallels in marketing tobacco and alcohol messages, and she referred the participants to a new NCI report entitled The Role of the Media in Promoting and Reducing Tobacco Use. This report is the 19th monograph in NCIs Tobacco Control monograph series and is the most comprehensive summary of the latest science on media communications in promoting and controlling tobacco use. The report is available in English and six other languages and can be obtained by calling 1-8000-4CANCER or downloading from the NCI Web site at http://www.cancercontrol.cancer.gov/tcrb/monographs/19/index.html. Confronting the Pushback. Dr. Floyd asked the marketing experts how to confront the pushback from physicians and consumers asking for absolute evidence to support the message that women should not use alcohol, tobacco, or other substances during pregnancy, and how to respond to the mixed messages being communicated in the media. Ms. Sokler responded that there is no empirical answer. You cant make a lot of traction arguing with people who are selling by the barrel, she said. She suggested that instead of spending time or resources in reaction, one should set your own course and keep putting your messages out in new and unique waysin surround sound. She mentioned that CDC supports a Hollywood, Health, and Society program for interfacing with writers in the entertainment industry. Ms. Herrera commented that, because multiple voices can make more of an impact, she has posted the message from different agencies and Web sites on her clinics bulletin board. Ms. Mahoney suggested that emphasizing the risks associated with a targeted behavior, which may be summarized in the question Why take the risk? worked well to promote the use of seatbelts and could be an effective approach to a campaign to reduce smoking and drinking during pregnancy. Reaching-out Best Approaches and Global Strategies Reaching out to Women at Risk: A Mothers Perspective Mary De Joseph, D.O., Philadelphia College of Osteopathic Medicine Dr. De Joseph shared her personal testimony as a biological parent of a child with FAS. Her take-home messages were: There is hope and Love heals. She poignantly described her own experience, from growing up in a multigenerational alcoholic family, to running away from home, graduating from high school, eventually chairing a department in a medical school, attending thousands of 12-step meetings, and giving birth to and rearing three children while trying to keep herself and her family together. She emphasized that hers is a common story with common themes experienced by many, many women who abuse alcohol and/or other substances. For her, the difference is that she is willing to share her story and has had the resources to come through to the other side (of her experience). Dr. De Joseph noted the need for publicizing more stories to illuminate the problem of alcoholism among women of childbearing age, and she cautioned that diagnostic and treatment services may be inundated as messages regarding the need to prevent substance-exposed pregnancies become more efficient and successful. The themes and observations she highlighted are relevant to marketing and intervention strategies and could be grouped. Understanding Alcoholism. In many families alcoholism is a multigenerational disease and an accepted way of life. For children in these families, drinking may seem quite natural, and their parents may tolerate or even encourage them to drink as well. For these children, alcohol misuse begins as a pediatric disease. Pediatricians, OB/GYNs, and treatment specialists need to be better informed and educated about this phenomenon so that alcohol use disorders in children can be identified and addressed early. Children and adolescents with alcohol use disorders readily engage in high-risk and criminal behaviors to obtain alcohol and yet stay under the radar in terms of detection. Running away, breaking and entering, and stealing may begin very early and are often followed by prostitution and unprotected sex, violence, and driving while intoxicated. The health effects mount, from early STDs to later fertility problems and eventual multiple organ disease (e.g., kidney, liver, sepsis, etc.). At all ages, alcoholics use alcohol to navigate lifes pathways and survive in the world. Often they are chasing happiness, as in if only I could, then Id be happy, and alcohol is used as a tool for getting by and for celebrating successes. For pregnant women who are alcoholics, the message to stop drinking is often misinterpreted to mean reducing the number of binges, for example, rather than stopping drinking altogether. Among these women, neglect of children is common. Diagnosis and Treatment. In the life course of an alcoholic, there are usually many missed opportunities to intervene and help. Schools, families, church members, and employers all need to be aware of the signs of alcoholism and have the capacity to respond. Young alcoholics often go through school and into the workplace without ever being screened for alcohol use. School-based identification and intervention for children with alcohol problems is needed at all levels and should be addressed in curricula and media materials. In workplaces, surveillance and screening for alcoholism need to be promoted. Intervention is necessarily a family affair. Too often, help may not arrive until after a child is born and the mother and infant are obviously experiencing acute alcohol withdrawal. Treating alcoholism at this stage is late and is likely to be complicated by a host of other factors (e.g., postpartum depression, anxiety), comorbid conditions (e.g., liver disease, mental health problems, undiagnosed childhood trauma), and medications. BIs will not be effective in such cases, which require long-term residential, intensive and individualized treatment for the mother. Educational and supportive services will be needed for significant others (especially fathers), and the child born with FASD will begin a long and difficult journey of expensive interventions, including special education. To forestall such expensive and extensive interventions, alcoholism must be identified, diagnosed, and treated earlier and within a systems approach centered around community-based services. The components of this system should include, but not be limited to, access to addiction and psychiatric treatment; medical insurance for families; community education about alcoholism (especially prenatal effects and contraception issues); early intervention and education targeting children and adolescents; FASD diagnostic centers (as part of a new map of services for children and young adults with FASD); and long-term intensive case management for mothers and children. Recovery and Relapse. Recovery for many alcoholics depends on receiving long-term residential treatment for alcoholism and all associated issues. Even so, recovery does not preclude relapse, and all families with alcoholics need to plan for relapse and develop a family relapse plan. Forgiveness. The spiritual principle of forgiveness needs to be embraced by all who are affected by alcohol-exposed pregnancies, including forgiveness for women who drink during pregnancy and their families and forgiveness for the health services community for not getting the message out and for not providing effective diagnostic and treatment services. Forgiveness heals and opens the door to the future. Keynote Address I: Best Approaches to Marketing the Message Drinking, Smoking, and Pregnancy Do Not Mix Lynn Sokler, National Center for Health Marketing, CDC Ms. Sokler described health marketing science and CDCs use of this science, drawing from lessons learned in commercial marketing. She elaborated on several key aspects of marketing a health message, including audience segmentation, social marketing to change behavior, and the media environment. In closing, she listed the features of effective health marketing. Health Marketing Science. At CDC, health marketing is considered an organizational function and a set of scientific processes to create, communicate, and deliver value to customers and to manage customer relationships to protect and promote the health of diverse populations. As in commercial marketing, health marketing draws on research in communication sciences, marketing sciences, behavioral and social sciences, and health and public health sciences. As in the commercial sector, health marketing focuses on a product, which is developed based on a perceived consumer need, and the delivery and exchange of the product. Getting health information and interventions to consumers when, where, and how they need them ( Public Health 2.0 ) is the overarching goal, much as it was in the successful distribution of Coca-Cola"! and cigarettes to American GIs in the 1940 s. Audience Segmentation. Tailoring a message and targeting an audience are essential, for even though people share similar demographics (e.g., age), they often differ on the key factors (e.g., beliefs) needed to effect behavior change. Socioecological marketing (SEM), which captures environmental, interpersonal, and intrapersonal influences on individuals and groups, is an effective strategy for defining the audience most likely to be affected by an intervention and for tailoring a message to that audience. An SEM study of African Americans, for example, uncovered four groups, or segments, with very different beliefs, outlooks, lifestyles, and interests. Social Marketing to Change Behavior. Marketers well understand that changing a behavior is difficult. First, one has to be precise about the change desired. For example, is the goal to cease and desist or to not initiate? Trying to change multiple behaviors (e.g., drinking and smoking) by a single message is probably too complex. The singularity of a message is important. Second, one has to move beyond information and education (e.g., We want you to stop drinking.) to supportive interventions that include, for example, peer advocates and policy or environmental changes. The aim is to find the sweet spot where a consumer will exchange a behavior for a gain (e.g., If you do this, then this will happen.). Third, analysis of individuals motivation and self-efficacy suggests that resources are better spent when targeted to individuals who perceive that they can (or cannot) change and want to change, rather than to those who perceive that they cannot change and do not want to change. The social marketing model for planning a campaign incorporates six features: Customer or consumer orientation; Behavior and behavioral goals; Intervention and marketing mix; Audience segmentation; Exchange (the real cost to the consumer); and Competition (factors that compete for the customers attention and time). CDC incorporated these features into CDCynergy, its online, CD-ROM tool for planning a social marketing campaign. Each step in this process is important, from problem description to market research, market strategy, interventions, evaluation, and implementation. Two CDC campaigns based on this process are the Autism Awareness Campaign, Learn the Signs. Act Early., to increase early action on childhood development disorders, and I Had to Fight, a breast cancer screening campaign targeted to women with disabilities to encourage them to have a mammogram. The New Media Environment. In designing a campaign, the communications and marketing process is fluid and constantly changing as new information about the target audience emerges to refine the message and its delivery. The options and challenges for delivering a message are broader today than before, and interventions no longer have to be expensive mass media efforts. Just as the message needs to be precisely tailored today, so does the delivery, and the venues for delivering a message must be addressed when designing the message. Marketers are well aware, for example, that an average person today listens to or reads seven sources of information daily, that people most frequently access the Internet for their health information, and that nine out of ten people buy a product based on peer recommendation, which is influenced by advertising. Effective Health Marketing. In sum, the six features of an effective health marketing campaign include the following: Have a clear behavioral objective to market. Know the right audience segment(s) to target. Tailor messages and approaches beyond information and education only. Understand how to reach the audience in multiple ways. Plan for the long haul to sustain the marketing over years. Be sure to evaluate and make refinements. Keynote Address II: Global Strategies in Health Marketing William A. Smith, Ed.D., Academy for Educational Development Dr. Smith presented another view of the essentials of a successful marketing strategy. He noted that changing behavior is a difficult challenge in any context, and, using examples from the U.S. and elsewhere, he presented two proven, related strategies: 1) ask the right questions; and 2) create a new service or product (i.e., not a message) to link to the message being promoted and to provide an attractive alternative to the behavior you want to change. Once a service or product has been created, well-studied and effective techniques of communication can then be used to market the service or product. Dr. Smith emphasized that people need help to change, not just messages, and that great advertising does not fix inadequate products and services. He cautioned that health is not the only thing that matters to people, and that stigma will drive behavior underground. Changing behavior can be accomplished in different ways. Education works for simple messages (as is done to prevent Reyes Syndrome), and regulation can force change (as it did for seatbelts). A third way is through marketing, and the private sector well understands that the goal is not to punish people, but to reward them and give them attractive alternatives that make them want to change. Telling a child to just say no to selling drugs, for example, does not alter his behavior, which represents, for him, his job and social connections. In contrast, Weight Watchers successfully conveys that losing weight is fun, easy, and a way to spend time with friends. Ask the Right Questions. To prevent and reduce substance-exposed pregnancies, the profile and concerns of women who could be targeted in a marketing campaign must be clearly understood. For example, 20 percent of pregnant women in the U.S. are profiled as follows: 1) early twenties 2) unmarried with a 5-year-old child; 3) never finished high school; 4) lives in an apartment where everyone else smokes and drinks; 5) smoked since the age of 15; and 6) stopped drinking when she became pregnant. When asked about not drinking or smoking, many say they would like to, but cannot because they have too many other problems and drinking or smoking provides relief from stress. It is this type of understanding and these types of questions that must be asked to plan an effective marketing campaign. To paraphrase Thomas Pynchon, If the wrong question is asked, it doesnt matter what the answer is. Create a New Product or Service. Behavior change is not about clever messages, but about creating services. Many marketing campaigns have failed because they did not ask the right questions or follow up on the answers to create an attractive service or product. In a recent study conducted in the Southwest, for example, one group of Hispanic women had first refused to put their children in car seats, despite safety messages, because they believed that their children were in the hands of God when traveling in a car. They eventually agreed to use the car seats, but only after they were blessed by a priest, thus providing assurance that the seats were acceptable in the eyes of God. The Got Milk? campaign, although very expensive, did not generate an increase in milk sales until manufacturers developed a new, attractive productthe small, colorful chug bottles with flavored milk. In this case, the initial advertising was important for generating awareness that milk could be cool, but it was not followed up with a new, more interesting product. The initial question should not have been, How can we advertise milk so it will be cool? but, rather, How can we change milk so it will be cool? The history of tobacco legislation is another example of real change that only came about through a change in service (e.g., broadcast bans on advertising) and product (e.g., excise taxes) over 40 years, despite all the warning labels. In Wisconsin, the Department of Transportation sponsored a successful and fun program called The Road Crew Limousine Service (complete with T-shirts, etc.) to reduce drinking and driving. Again, this strategy developed from asking the right question (i.e., how to safely transport people who intend to drink at social gatherings) and responding appropriately to the answer. In Madagascar, the red card has been phenomenally successful in beginning to change social norms related to sex and violence. By asking the right questions, it was possible to devise an inexpensive product that fits within the cultural context of marked gender inequality and widespread sexual abuse of women. Television spots advertised the red card, and social organizations and networks distributed them to women to use when they cant find the right words to stop unwanted advances from men. The card has become a non-aggressive, empowering tool for women allowing them to communicate the message that a man is making them uncomfortable without inciting his anger. Men in Madagascar have actually begun to joke about the red card while continuing to respect its message. As this example shows, an effective marketing strategy that links a public health message to a product or service that facilitates behavior change can also break through social taboos, reduce stigma, and change social norms. To prevent or reduce substance-exposed pregnancies, services are needed for women. An effective marketing strategy would begin by asking women who are of childbearing age and who smoke or drink what services they need. Based on the answer, positive programs that offer a solution, in addition to raising awareness of the problem, could then be created and marketed (e.g., Hug a mom. Stop stressing and start sharing.). The answer might well be I need a program that helps me stop drinking and smoking, in which case the message to abstain from alcohol and tobacco during pregnancy should be linked to information that helps women access effective treatment services. For example, one California program sponsors community baby showers that may be used as a vehicle to provide maternal and child health education and information about substance abuse treatment services available in the community. In this case, the product attached to the abstinence message is the baby shower and the useful gifts, helpful information, and supportive environment it offers. International Birth Mothers Network Kathleen Mitchell, M.H.S., LCADC, National Organization on Fetal Alcohol Syndrome (NOFAS) Ms. Mitchell gave a brief overview of recent legislative action in the U.S. Congress related to the prevention of FASD. She then shared her experience as the birth mother of a child with FAS and described the Birth Mothers Network (BMN). Ms. Mitchell also serves as Vice President and Spokesperson for NOFAS. Congressional and Related Action. On October 4, 2007, Senators Tim Johnson (D-ND), Lisa Murkowski (R-AK), and others introduced Senate Bill 2141 (S.2141.IH), Advancing FASD Research, Prevention, and Services Act. Similar to the original bill of 1998, it seeks to amend the Public Health Service Act to reauthorize and extend the Fetal Alcohol Syndrome Prevention and Services program and to provide $27 million to federal agencies for FY 20082012. Information about the legislation is available on the NOFAS Web site ( HYPERLINK "http://www.nofas.org" www.nofas.org; click on Action Alert). Being the Birth Mother of a Child with FAS. Ms. Mitchell noted that birth families of children with FAS experience different issues than other families, and that these issues often do not become clear until there is an opportunity to dialogue with other mothers and families of children with FAS. Recognizing that your child lives with a disability because you drank during pregnancy is a sad realization that often is compounded by late diagnosis for the child. Without diagnosis or treatment of women who are unable to stop drinking during pregnancy, all of their children will be exposed to alcohol; some may die and others may have severe disabilities. Long after recovery from alcoholism, mothers face continuing shame and stigma from neighbors, childrens teachers and friends, extended family members, physicians and dentists, and coworkers. Stigma is a major issue and causes problems on many levels. Faced with the prospect of stigma, women who drink during pregnancy may deny they have a problem and be reluctant to pursue a diagnosis. Some physicians are reluctant to diagnose FAS because of the labeling and stigma that ensues for mothers and children. Stigma can lead to relapse. Alcoholism must be viewed as a progressive disease and should be diagnosed and treated within a disease management model, which would reduce stigma and thereby increase the likelihood of preventing FASD. Because addicts are the highest risk group for having a child with FASD and many addicts have themselves been exposed to alcohol in utero, parents and children who are in addiction treatment programs need to be assessed for FASD to facilitate early intervention and improve outcomes. Whether or not alcohol is identified as the mothers primary substance of abuse, assessment should include asking questions about both drinking in general and drinking during pregnancy because the answers may suggest a need to modify treatment. A platform that includes research and implementation is needed to inform the broader health care system about addiction and FASD. Birth Mothers Network. The NOFAS Circle of Hope, also known as the BMN, was formed in 2004 and funded in 2005 by SAMHSAs FASD Center for Excellence. The BMN is a global network, with sites located throughout the U. S., to reach out and connect birth mothers of children with FASD. Its mission is to increase understanding and support and strengthen recovery for women who drank during their pregnancy(s), and their families. The goals are to improve and strengthen the lives of birth families, provide peer support for birth families, and decrease the stigma, blame, and shame that birth families may experience. The BMN accomplishes its mission and goals by educating agencies that serve high-risk women, educating policymakers and agency directors, securing funding and other resources to sustain itself, and creating momentum and cohesiveness for national action through its national strategic plan. The values guiding the network are utmost confidentiality, honesty and integrity of all members, reducing the stigma of FASD, and assuring a safe environment for women. With SAMHSA support, the BMN has held two retreats, in 2005 and 2008; established a Web page on the NOFAS Web site (  HYPERLINK "http://www.nofas.org" www.nofas.org ) developed a video entitled Hope for Women in Recovery; and held three summits (in MD, AZ, and NC) for women in recovery. The network includes a core group of mothers who are nationally noted speakers on FASD. Still a grass-roots effort, the BMN is distributing its materials widely and inviting birth mothers to join the network. Legislative Update George Hacker, J.D., Center for Science in the Public Interest Mr. Hacker described recent projects undertaken by the Center for Science in the Public Interest (CSPI) to advocate for prevention policies to reduce harm related to alcohol use in the U.S. and abroad. Since 1981, CSPI has advocated for higher taxes on alcohol, restrictions on marketing and advertising alcohol, and improved labeling of alcohol products. Most of the policies CSPI promotes have had only tangential relevance to fetal alcohol problems, yet its late 1980s effort, which resulted in adding product warning labels to alcoholic beverages, was a first step towards stigmatizing alcohol, at least for pregnant women. CSPI is now recommending four strategies specifically to increase public awareness of FASD: Require warning messages about drinking during pregnancy in all alcohol advertising, especially in ads that clearly target women of childbearing years. Require visible and legible rotating health warnings on alcohol product containers. Establish a comprehensive, paid national media campaign to discourage drinking during pregnancy. Require universal posting of warning signs about drinking during pregnancy wherever alcohol is sold. These recommendations have evolved from CSPIs research and increased awareness of FASD, largely through Mr. Hackers participation on CDCs National Task Force on FASD and a recent study of alcohol advertising in womens magazines. CDCs National Task Force on FAS > Action Guide. Since the U.S. Surgeon Generals 2005 renewed advisory on drinking during pregnancy, which was recommended by the Task Force, little attention has been paid to the problem, and state efforts to mandate alcohol warning signs where alcohol is sold have stalled. Seeking to raise visibility of the problem among media, policymakers, community groups, and health providers, CSPI has collaborated with others to prepare a new action guide on mandatory point-of-purchase messaging about alcohol and pregnancy. This new guide, which will soon be available from the CSPI Web site ( HYPERLINK "http://www.cspinet.org/alcohol" www.cspinet.org/alcohol), is intended to help communities raise the issue at state and local levels. Only 23 states currently require mandatory point-of-purchase warning signs that relate birth defects to drinking alcohol during pregnancy. Alcohol Advertising in Womens Magazines. In this study, CSPI examined the messages and number of alcohol ads for 1 year in 10 leading womens magazines targeting women of childbearing age. The median age of readers was mid-thirties. Alcohol ads accounted for 2.6 percent of the total number of ads in the magazines, 26.7 percent of ads for consumable products; and 54 percent of all ads for beverages. Vogue and Cosmopolitan had the highest percentages of alcohol ads (4.7 percent and 2.8 percent, respectively) and the lowest percentages of ads for other beverages (0.1 percent for both). Articles across the 10 magazines had very little to say about serious alcohol problems, and not one article mentioned drinking during pregnancy. Many articles seemed to be targeting binge-drinking young women, a group at high risk for having an alcohol-impaired child. Related Efforts. CSPI was one of a number of groups that helped to pass the STOP (Sober Truth on Preventing Underage Drinking) Act, which for the first time provides federal dollars to seek a coordinated approach among all federal agencies addressing underage drinking and to support prevention programs in communities and colleges. The legislation also provides support for a public service announcement campaign and research on alcohol advertising and other issues. More recently, CSPI has been trying to counteract the efforts of Responsibility Matters, which is promoting the Amethyst Initiative to enlarge the discussion about whether the law that prohibits drinking before age 21 is an appropriate means of reducing underage drinking, particularly binge drinking. CSPI has also run a campaign for alcohol-free sports television, which is intended to reduce young peoples exposure to alcohol advertising messages on television. Almost 400 college presidents have signed a pledge to help eliminate this advertising in the National Collegiate Athletic Association (NCAA). In 2003, CSPI petitioned the Alcohol and Tobacco Tax and Trade Bureau for better labeling of ingredients and other information (e.g., serving size, alcohol content, moderate drinking guidelines) on alcoholic beverages. Responding to a counterattack by the alcohol industry, CSPI is pushing for more research before a final ruling is issued. For a long time, CSPI has advocated for increased alcohol taxes, a measure that may now be more attractive as a way to raise funds for federal programs. Lately, CSPI has been successful in removing or blocking from the market new high-energy drinks (e.g., Spikes, Tilt, Bud Extra, Sparks) that are targeted to young people and have high alcohol and/or caffeine content. Future Directions and Framing an Action Agenda Breakout Sessions: Future Directions The participants divided into three breakout groups that met for approximately 1.25 hours to discuss and recommend future directions for research. The topics and facilitators were: Preventing Prenatal Exposure to Alcohol, Tobacco, and Other Substances of Abuse in Universal and Selected Populations Facilitators: Susan Maier, Ph.D. and Mary Kate Weber, M.P.H. Intervening with Women with Problem Drinking and Other Substance Misuse (Indicated Populations) Facilitators: Norma Finkelstein, Ph.D. and Ellen Hutchins, Sc.D., M.S.W. Engaging Partners, Parents, Peers, and Policymakers Facilitators: John McGovern, M.G.A. and Judith Thierry, D.O., M.P.H. For each group, the facilitators presented to the full meeting a verbal report on the issues addressed. Specific recommendations suggested in each report are listed in Reports from Breakout Sessions page 55. Framing an Action Agenda: Next Steps Deidra Roach, M.D., NIAAA, NIH Dr. Roach highlighted some main themes addressed in the presentations and discussions at the meeting. Among other topics, overarching themes related to the epidemiological evidence regarding substance misuse among women of childbearing age; best approaches to marketing health messages about the potential harm caused by substance use during pregnancy; and strategies for linking those messages to effective substance abuse treatment services. The Evidence: Some Themes Society is ambivalent toward prenatal alcohol and other substance use, in that it is both stigmatized and supported by the popular culture. Substance abuse is a universal phenomenon affecting women of all cultures and economic backgrounds, and everyone must be involved in solving the problem. Substance abuse is also a transgenerational phenomenon influenced by complex historical, cultural, and socioeconomic factors. These factors should be taken into consideration in the design of substance abuse treatment and prevention programs for women of childbearing age. Alcohol is a powerful driver of high-risk sexual behavior, fueling both substance-exposed pregnancies and HIV infection. Trauma (physical, emotional, psychological) and violence are a large part of the problem of substance-exposed pregnancies that cannot be ignored, and comorbid psychological distress must be addressed. Contraception is an essential part of the formula for preventing substance-exposed pregnancies. Preventing and reducing substance-exposed pregnancies is a multifaceted challenge that needs to be confronted by a community of partners (e.g., parents, peers, health care providers, policymakers, media) with multi-level solutions. Best Approaches and Strategies: Some Themes The U.S. national health care system faces serious challenges to its efforts to provide coordinated care for people in need of substance abuse services. The most critical need is for services; that is, well-integrated, multidisciplinary services. Providers must be trained to provide these services, starting in medical school. Screening, assessment, and treatment work, and although assessment alone has an impact on substance misuse, there is need for further development of the full continuum of care that includes both BIs and specialty addiction treatment services. Evidence-based, effective, and affordable interventions (e.g., including pharmacotherapies) need to be developed, and those that are already available need to be utilized more. Integration of HIV care with substance abuse treatment services has significant potential to improve clinical outcomes and quality of life for women with co-occurring HIV infection and substance use disorders. More RCTs are needed to evaluate promising interventions, but the evaluation of such interventions need not always rise to the level of an RCT, which may be prohibitively expensive. More rapid and less formal approaches to testing promising interventions need to be considered. The reasons that certain interventions do not work for some individuals need to be clarified and understood, and alternative approaches to reaching these individuals should be evaluated. The lessons to be learned from apparent treatment failures should not be overlooked. To be most effective, messages regarding the need to abstain from substances during pregnancy need to be linked to a product (e.g., high-quality treatment services), and messages should be developed in collaboration with the women who comprise the target audience for the campaign. The women themselves know how the messages need to be crafted to have the greatest impact. Forgiveness is at the heart of the matter. Not forgiving means silence and stigma. Next Steps Dr. Roach suggested the following four actions to follow up on the momentum of the meeting: 1. Strengthen the network that started with this meeting. 2. Form a steering committee to develop, within a year, a plan for a public health campaign to prevent substance-exposed pregnancies, including a mission statement, goals, strategies, and timeframe. 3. Initiate a Listserv that includes meeting participants and other interested persons and groups. With the cooperation of involved federal, state, and local government agencies and private partners, consider convening an annual meeting on best approaches to preventing substance-exposed pregnancies. Reports from Breakout Sessions Preventing Prenatal Exposure to Alcohol, Tobacco, and other Substances of Abuse in (Universal and Selected) Populations Mary Kate Weber, M.P.H., CDC and Susan Maier, Ph.D., NIAAA, The participants acknowledged the various interventions available to women who abuse substances. But, they also emphasized the importance of preventing women from needing these interventions in the first place by getting prevention information and diagnostic services to women early, before they progress to addiction. A key question still to be answered is: Which audience should be targeted first and, for that audience, which preventive interventions would be most effective? The group offered the following specific recommendations related to three topics: Target audiences, existing efforts, and prevention strategies. Target Audiences Conduct formative research and needs assessments to better understand and know the target audiences (e.g., women who use substances, health care providers). Adapt prevention messages to specific audiences (e.g., providers, educators) to assure that these messages will reach the intended audiences and be used by them. Conduct research to better understand, in general, the root causes of alcohol use in American society. Conduct research to increase the understanding of substance use from a cultural perspective. Existing Efforts Survey states and communities to identify effective prevention materials already in use. Tap into existing efforts in states and communities (e.g., initiatives related to preconception care and underage drinking). Prevention Strategies Evaluate prevention approaches, particularly universal strategies, to determine which are most effective for preventing substance-exposed pregnancies and FASD. Consider environmental approaches (e.g., warning labels, advisories, excise taxes, controls on advertising) to reduce alcohol consumption in general. Engage the alcohol industry in discussions of how to get the prevention message out and the need to reduce alcohol advertising targeted to women. Assure funding to sustain prevention efforts over time and to be able to modify efforts to keep prevention messages fresh and visible. Support work on alcohol-related issues beyond FASD. Intervening with Women with Problem Drinking and other Substances Misuse (Indicated Populations) Norma Finkelstein, Ph.D., and Ellen Hutchins, Sc.D., M.S.W. The participants in this breakout group engaged in a wide-ranging discussion that suggested the following recommendations related to five issues: Screening; linkage of services; evidence-based services; reimbursement and sustainability; and education. Screening Improve recognition of women with FAS or FASD in screening, assessment, and treatment programs and centers by ensuring that women are screened for these disorders and for related cognitive impairments. Consider the content and timing of screening for cognitive impairments among women with substance use disorders. Such screening and assessment should be conducted early, perhaps as a component of other types of assessments, and interventions should be adapted based on the results of the assessment. Linkage of Services Delineate gaps in the continuum of care available to women who abuse substances, and develop connecting bridges to cross these gaps and link screening with BI and subsequent treatment services. Review the appropriateness of various models for achieving successful linkages, including SBIR (screening, brief intervention, referral), SBILT (screening, brief intervention, and linkage to treatment), the Kaiser Permanente model, case management, and Maines warm handoffs approach. Learn from women who have had substance-exposed pregnancies about their concerns and issues (e.g., stigma) by tapping into focus groups and similar conversations. Address, in particular, the reasons that women with cognitive disabilities leave substance abuse treatment, and identify ways to help them be successful (e.g., one-on-one mentoring, adapted rules and expectations) in intervention and treatment programs. Evidence-Based Practices Conduct research to examine and clarify the unintended consequences of using evidence- based practices in real-world settings. Reimbursement and Sustainability Focus attention on the issue of parity in reimbursement to gain support for linking services across the continuum of care. Involve the Centers for Medicare and Medicaid Services (CMS) in these discussions. Identify effective cost-sharing approaches for services in communities and make this information widely available. Foster greater familiarity with the ICD-9 codes among Title V directors and health care providers. Assure reimbursement over time to sustain model programs and services after federal funding ends. Education Educate state and federal legislators and policymakers about effective and appropriate treatments for both non-pregnant women who are in their childbearing years and pregnant women who abuse substances. Ensure that information about FAS/FASD and substance-exposed pregnancy is incorporated into medical education. Engaging Partners, Parents, Peers, and Policymakers Facilitators: John McGovern, M.G.A. and Judith Thierry, D.O., M.P.H. The participants in this breakout group focused on primary care, mentors and stakeholders, and professional groups. In their report, they urged that those who say that it could not be done should not interrupt those who are doing it. The report included the following recommendations. Primary Care Include and involve the broad array of primary care providers (e.g., nurses, paraprofessionals, providers of ancillary services, case managers, community health workers) in the prevention and treatment of substance-exposed pregnancies. Foster partnerships among funders and care settings (e.g., community health centers, school-based health centers) to better address the comprehensive needs of women, especially adolescents, who seek care for substance abuse. Understand and address the reasons for physicians reluctance to assess and refer women for substance abuse treatment (e.g., stigma; lack of resources, training, or materials). Offer training in effective interviewing and counseling styles and techniques. Promote understanding of addiction as a disease. Build language about addiction (e.g., recovery, sobriety) into messages to parents and the general public to help override a prevailing sentiment that drinking is a personal issue and responsibility. Understand that addiction is a pediatric disease as well as an adult-spectrum disease, and reach out early to young children and adolescents who are initiating risky behaviors. Mentors and Stakeholders Involve key stakeholders (e.g., parents, caregivers, and paraprofessionals) in relating stories of substance abuse among women and children to policymakers and the public. Engage peer mentors, adult mentors, and parents in getting the message out about substance abuse prevention and treatment through community organizations (e.g., ParentTeacher Associations, Head Start, child care centers, WIC). Identify peer mentors for young men, in particular, who abuse substances but are largely without access to care and at high risk for incarceration and/or some other type of institutionalization (e.g., psychiatric hospitalization, etc.). Professional Groups Work closely with professional organizations and groups to identify and overcome barriers to prevention and care. Collaboratively champion comprehensive, multidisciplinary, system-wide approaches that build a platform of care for high-risk women and children faced with a myriad of cascading social challenges. Wrap-Up and Closing Remarks Deidra Roach, M.D. Dr. Roach thanked the American Legacy Foundation and the participants and speakers. She also thanked Dr. Sally Anderson, Coordinator and Executive Secretary of the ICCFAS; Mr. Wendell Williams, for technical support; and the members of the Working Group on Women, Drinking, and Pregnancy. 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(Thesis), Paris, 1957. Serdula M, Williamson DF, Kendrick JS, Anda RF, Byers T. Trends in alcohol consumption by pregnant women: 1985 through 1988. J Am Med Assoc 265:876-879, 1991. Sobell, MB, Sobell, LC, Johnson, K, Velasquez, MM, Mullen, PD, von Sternberg, K, Nettleman, MD, Ingersoll, KS, Ceperich, SD, Project CHOICES Intervention Research Group, Rosenthal, J, Floyd, RL, Sidhu, JS. Motivational intervention to reduce alcohol-exposed pregnanciesFlorida, Texas, and Virginia, 1997-2001. Morbidity and Mortality Weekly Report 52(19):441-444, May 16, 2003. (Link at:  HYPERLINK "http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5219a4.htm" \t "_parent" http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5219a4.htm). Substance Abuse and Mental Health Services Administration. Results from the 2006 National Survey on Drug Use and Health: National findings. NSDUH series H-32, Department of Health and Human Services publication No. SMA 07-4923. Rockville, MD: Office of Applied Studies 2007. (Link at  HYPERLINK "http://www.oas.samhsa.gov/nsduh/reports.htm#2k6" http://www.oas.samhsa.gov/nsduh/reports.htm#2k6 .) Ulleland CN, Wennberg RP, Igo RP, Smith NJ. The offspring of alcoholic mothers. Abstracts from Annual Meeting of the American Pediatric Society and Society for Pediatric Research 93, 1970. Appendix Agenda..65 Speakers and Formal Discussants.69 List of Participants73  Preventing Alcohol, Tobacco, and Other Substance-exposed Pregnancies: A Community Affair Hosted by: Interagency Coordinating Committee on Fetal Alcohol Syndrome Work Group on Women, Drinking, and Pregnancy Sponsored by: National Institute on Alcohol Abuse and Alcoholism, NIH American Legacy Foundation AGENDA Tuesday, September 23, 2008 8:00 a.m. Registration and Continental Breakfast 8:30 a.m. Welcome, Introduction, and Comments Deidra Roach, M.D., NIAAA, NIH; Leader, ICCFAS Women, Drinking, and Pregnancy Work Group Kenneth R. Warren, Ph.D, NIAAA, NIH; ICCFAS Chairperson 8:45 a.m. Overview of Evidence on the Prevalence of Alcohol, Tobacco, and Other Substance Use Among Women of Childbearing Age Louise Floyd, R.N., D.S.N., Centers for Disease Control and Prevention Amy Elliott, Ph.D., Sanford Research/University of South Dakota 9:15 a.m. Women and Substance Abuse Carrie Randall, Ph.D., Medical University of South Carolina 9:35 a.m. Prenatal Exposure Effects of Alcohol, Tobacco, and Other Commonly Used Substances Claire D. Coles, Ph.D., Emory University, School of Medicine 10:00 a.m. Panel Discussion: Prioritizing Populations At-risk Facilitator: Carrie Randall, Ph.D. The role of genetic, developmental, cultural and other environmental factors in determining risk. What are the important messages to get out concerning differences in the vulnerability of women and men to the harmful effects of alcohol and other substances of abuse? 10:30 a.m. Break 10:45 a.m. Identification of At-risk Alcohol and Other Substance Use and Intervening with Women of Childbearing Age: Federal Activities Louise Floyd, R.N., D.S.N., Centers for Disease Control and Prevention 10:55 a.m. Substance Abuse and Mental Health Services Administration Patricia Getty, Ph.D. 11:05 a.m. Health Resources and Services Administration John McGovern, M.G.A. Ira J. Chasnoff, M.D., Childrens Research Triangle 11:15 a.m. National Institute on Alcohol Abuse and Alcoholism Susan Maier, Ph.D. 11:25 a.m. Intervening in the Preconception Period Karen Ingersoll, Ph.D., University of Virginia 11:45 a.m. Intervening with Pregnant Women Grace Chang, M.D., Brigham and Womens Hospital 12:05 p.m. Intervening with Women with and At-risk for HIV Infection Mary McCaul, Ph.D., Johns Hopkins University 12:25 p.m. Panel Discussion Facilitator: Grace Chang, M.D.; Brigham and Womens Hospital How well are known effective interventions being integrated into existing systems of care? What can be done to improve adoption of evidence-based practices? What can be done to address gaps in existing service systems (e.g., services for women who do not meet abuse/dependence criteria, but need something more intensive than a brief intervention)? 12:55 p.m. Working Lunch (Provided) Reaching out to Special Populations: The Mississippi Experience Debbie Long, Mississippi FASD Prevention Project An Urban California Experience Lee Kaskutas, Ph.D., University of California, Berkeley Presented by: Constance Weisner, Ph.D., University of California, San Francisco The Cheyenne River Reservation Experience Sherlynn Herrera, Reclaiming the Sacred Trust Project 2:15 p.m. Measuring the Cost-effectiveness of Interventions in the Health Care System: Making the Business Case Constance Weisner, Ph.D. 2:35 p.m. Marketing the Message: Lessons Learned from the Centers for Disease Control and Prevention Center on Health Marketing Lynn Sokler, CDCP National Center on Health Marketing 2:55 p.m. Marketing the Message: Lessons Learned from the Office on Smoking and Health Judith Berkowitz, Ph.D., Centers for Disease Control and Prevention Michelle Johns, M.A., M.P.H., Centers for Disease Control and Prevention 3:15 p.m. Marketing the Message: American Legacy Foundation Laura Hamasaka Jeffrey Costantino, M.B.A. 3:35 p.m. Break 3:55 p.m. Panel Discussion Facilitator: Ellen Hutchins, Sc.D., M.S.W. What may be some of the best approaches to getting the message out about the serious risks associated with drinking, smoking, and other substance use during pregnancy and the preconception period? How do we engage a wide range of stakeholders (e.g., partners, peers, parents, health care providers, policymakers)? How may innovative communication technologies be employed to reach and engage the maximum number of stakeholders? 4:40 p.m. Day 1 Wrap-up and Looking Ahead Deidra Roach, M.D., NIAAA Wednesday, September 24, 2008 8:00 a.m. Continental Breakfast 8:30 a.m. Welcome and Recap of Day 1 8:35 a.m. Reaching Out to Women at Risk: A Mothers Perspective Mary De Joseph, M.D., Philadelphia College of Osteopathic Medicine 9:00 a.m. Keynote Address I: Best Approaches to Marketing the Message Drinking, Smoking, and Pregnancy Do Not Mix Lynn Sokler, CDCP National Center on Health Marketing 9:45 a.m. Keynote Address II: Global Strategies in Health Marketing William A. Smith, Ed.D., Academy for Educational Development 10:30 a.m. Break 10:45 a.m. Break-out Sessions: Future Directions for Preventing Prenatal Exposure to Alcohol, Tobacco, and Other Substances of Abuse in (Universal and Selected Populations) Facilitators: Susan Maier, Ph.D. and Mary Kate Weber, MPH Future Directions for Intervening with Women with Problem Drinking and Other Substances Misuse (Indicated Populations) Facilitators: Norma Finkelstein, Ph.D. and Ellen Hutchins, Sc.D., M.S.W. Future Directions for Engaging Partners, Parents, Peers, and Policymakers Facilitators: John McGovern, M.G.A. and Judith Thierry, D.O., M.P.H. 12:00 p.m. Working Lunch (Provided) International Birth Mothers Network Kathleen Mitchell, M.H.S., L.C.A.D.C., NOFAS Legislative Update George Hacker, J.D., Center for Science in the Public Interest 1:00 p.m. Break-out Session Reports 1:45 p.m. Framing an Action Agenda: Next Steps Deidra Roach, M.D., NIAAA 2:15 p.m. Wrap-up and Closing Remarks Deidra Roach, M.D., NIAAA Speakers and Formal Discussants Judy Berkowitz, Ph.D. Health Communication Specialist Centers for Disease Control and Prevention 4770 Buford Highway, NE, MS K-50 Atlanta, Georgia 30341 Phone: 770-488-6151 Fax: 770-488-5939 Email:  HYPERLINK "mailto:jberkowitz@cdc.gov" \o "mailto:jberkowitz@cdc.gov" jberkowitz@cdc.gov Grace Chang, M.D., M.P.H. Associate Professor Department of Psychiatry Brigham and Womens Hospital 221 Longwood Avenue Boston, MA 02115 Phone: 617-732-6775 E-mail: gchang@partners.org Claire D. Coles, Ph.D. Professor Emory University School of Medicine 1256 Briarcliff Road, NE Atlanta, GA 30306 Phone: 404-712-9814 Fax: 404-712-9809 Email: ccoles@emory.edu Jeffrey Costantino Senior Director Cessatation Marketing American Legacy Foundation 1724 Massachusetts Avenue, NW Washington, DC 20036 Phone: 202-454-5555 Fax: 202-454-5599 Mary DeJoseph, D.O. Physician/Faculty Philadelphia College of Osteopathic Medicine 609 Walnut Street Palmyra, NJ 08065 Phone: 609-760-2670 Email: marydejo@comcast.net Norma Finkelstein, Ph.D., M.S.W. Executive Director Institute for Health and Recovery 349 Broadway Cambridge, MA 02141 Phone: 617-661-3991 Fax: 617-661-7277 E-mail: normafinkelstein@healthrecovery.org R. Louise Floyd, R.N., D.S.N. Team Leader/Behavioral Scientist Fetal Alcohol Syndrome Prevention Team National Center for Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention 1600 Clifton Road Atlanta, GA 30329 Phone: 404-498-3923 Fax: 404-498-3550 Email: rlf3@cdc.gov Patricia B. Getty, Ph.D. Project Officer FASD Center for Excellence Division of Systems Development Acting Branch Chief Center for Substance Abuse Prevention Substance Abuse & Mental Health Services Administration One Choke Cherry Road, #4-1027 Rockville, MD 20857 Phone: 240-276-2577 Fax: 240-276-2580 Email: Patricia.Getty@samhsa.hhs.gov George Hacker, J.D. Director Alcohol Policies Center for Science in the Public Interest 1875 Connecticut Avenue, NW, Suite 300 Washington, DC 20009-5728 Phone: 202-777-8343 Fax: 202-265-4954 Email: ghacker@cspinet.org Laura Hamasaka Associate Vice President Program Development & TAT American Legacy Foundation 1724 Massachusetts Avenue, NW Washington, DC 20036 Phone: 202-454-5587 Fax: 202-454-5599 Email: LHamasaka@americanlegacy.org Sherlynn Herrera Case Manager Cheyenne River Sioux Tribe PO Box 590 Eagle Butte, SD 57625 Phone: 605-964-4844 Fax: 605-964-1062 Email: herreras2004@hotmail.com Ellen Hutchins, Sc.D., M.S.W., M.P.H. Consultant 66 Florence Street Melrose, MA 02176 Phone: 781-665-0985 Fax: 781-665-0985 Email: ellen66@verizon.net Karen Ingersoll, Ph.D. Associate Professor of Psychiatry and Neurobehavioral Sciences University of Virginia 1670 Discovery Drive, Suite 110 Charlottesville, VA 22911 Phone: 434-243-0581 Fax: 434-973-7031 Email:  HYPERLINK "mailto:kareningersoll@virginia.edu" \o "mailto:kareningersoll@virginia.edu" kareningersoll@virginia.edu Michelle Johns, M.A., M.P.H. Public Health Educator Centers for Disease Control and Prevention 4770 Buford Highway, NE MS K-50 Atlanta, GA 30341 Phone: 770-488-5289 Email: mjohns@cdc.gov Lee Kaskutas, Dr.PH. Senior Scientist Alcohol Research Group University of California, Berkeley 50 University Hall Berkeley, CA 94720-7360 Phone: 510-597-3440 Fax: 510-985-6459 Email:  HYPERLINK "mailto:lkaskutas@arg.org" lkaskutas@arg.org Debbie Long FASD Project Director Pine Belt Mental Healthcare Resources PO Box 1030 Hattiesburg, MS 39403 Phone: 601-582-0913 Fax: 601-582-1607 Email: dm82200@yahoo.com Susan Maier Health Scientist Administrator National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane, Suite 2017 Bethesda, MD 20892 Phone: 301-451-7583 Email: maiers@mail.nih.gov Mary E. McCaul, Ph.D. Professor Johns Hopkins University School of Medicine 911 North Broadway Baltimore, MD 21209 Phone: 410-955-5439 Fax: 410-955-4769 E-mail: mmccaul1@jhmi.edu John H. McGovern, M.G.A. Senior Project Officer Maternal and Child Health Bureau Health Resources and Services Administration 5600 Fishers Lane, Room 18-12 Rockville, MD 20857 Phone: 301-443-5805 Fax: 301-594-0186 Email: jmcgovern@hrsa.gov Kathleen T. Mitchell, M.H.S., L.C.A.D.C. Vice President International Spokesperson National Organization on Fetal Alcohol Syndrome 900 17th Street, NW, Suite 910 Washington, DC 20006 Phone: 202-785-4585 E-mail:  HYPERLINK "mailto:mitchell@nofas.org" mitchell@nofas.org Renee Parker Site Manager/CM UNM-CASAA PO Box 477 Belcourt, ND 583216 Phone: 701-477-7928 Fax: 701-477-5491 Email: tmfas.rparker@hotmail.com Carrie Randall, Ph.D. Professor of Psychiatry Director Charleston Alcohol Research Center Medical University of South Carolina MSC 861 Charleston, SC 29425 Phone: 843-792-5206 Fax: 843-792-5204 Email: randallc@musc.edu Deidra Roach, M.D. Health Scientist Administrator Division of Treatment and Recovery Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Room 2040, MSC 9304 Bethesda, MD 20892-9304 Phone: 301-443-5820 Fax: 301-443-8774 Email:  HYPERLINK "mailto:droach@mail.nih.gov" droach@mail.nih.gov For overnight express mail: Rockville, MD 20852-1705 William Smith Executive Vice President Academy for Educational Development 1825 Connecticut Avenue, NW Washington, DC 20009 Phone: 202-884-8750 Fax: 202-884-8752 Email: bsmith@aed.org Lynn Sokler Chief Marketing and Communication Strategy National Center for Health Marketing Centers for Disease Control and Prevention 1600 Clifton Road Atlanta, GA 30333 Phone: 404.498-6617 Email: Lsokler@cdc.gov Judith Thierry, D.O., M.P.H. Maternal and Child Health Coordinator Indian Health Service 801 Thompson Avenue, Suite 300 Rockville, MD 20852 Phone: 301-443-5070 Fax: 301-594-6213 Email:  HYPERLINK "mailto:Judith.Thierry@ihs.gov" Judith.Thierry@ihs.gov Kenneth R. Warren, Ph.D. Acting Director National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Room 2005, MSC 9304 Bethesda, MD 208929304 Phone: 301-443-5494 Fax: 301-443-7043 Email:  HYPERLINK "mailto:kwarren@mail.nih.gov" kwarren@mail.nih.gov For overnight express mail: Rockville, MD 20852-1705 Mary Kate Weber, M.P.H. Behavioral Scientist Centers for Disease Control and Prevention 1600 Clifton Road, MS-E86 Atlanta, GA 30333 Phone: 404-498-3926 Fax: 404-498-3040 E-mail:  HYPERLINK "mailto:muw1@cdc.gov" muw1@cdc.gov Constance Weisner, Dr.PH., L.C.S.W. Principal Investigator University of California, San Francisco 2000 Broadway, 3rd Floor Oakland, CA 94612 Phone: 510- 891-3585 Fax: 510-891-3606 Email: georgina.i.berrios@kp.org List of other Participants Kerri Agee Social Work Intern Health Resources and Services Administration 5600 Fishers Lane, Room 18-12 Rockville, MD 20857 Phone: 301-443-9720 Email: kagee@hrsa.gov Shayna Amerasinghe Training/Technical Assistance Coordinator FASD Center for Excellence 2101 Gaither Road, Suite 600 Rockville, MD 20850 Phone: 301-527-6802 Email:  HYPERLINK "mailto:shayna.amerasinghe@ngc.com" shayna.amerasinghe@ngc.com Ann L. Anderson, M.D., M.P.H. Medical Officer Division of Treatment Research and Development National Insitute on Drug Abuse, NIH 6001 Executive Boulevard Room 4123, MSC 9551 Bethesda, MD 20892-9551 Phone: 301-435-0767 Fax: 301-443-2599 Email: aa135m@nih.gov Sally Anderson, Ph.D. Coordinator and Executive Secretary Interagency Coordinating Committee on Fetal Alcohol Syndrome National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Bethesda, MD 20892-9304 Phone: 301-443-6371 Fax: 301-443-7043 Email: sanders1@mail.nih.gov Megan Bauer Program Intern MD-NCA Chapter March of Dimes 2700 S. Quincy Street, #220 Arlington, VA 22206 Phone: 703-824-0111 Fax: 703-578-4928 Email: megan_byu@hotmail.com Anton Bizzell, M.D. Vice President of Health and Clinical Services DB Consulting Group 8403 Colesville Road, 10th Floor Silver Spring, MD 20910 Phone: 301-589-4020 Email: abizzell@dbconsultinggroup.com Michele Bloch, M.D., Ph.D. Medical Officer National Cancer Institute, NIH Executive Plaza North, Room 4038 6130 Executive Boulevard Bethesda, MD 20892-7337 Phone: 301-402-5284 Fax: 301-496-8675 Email: blochm@mail.nih.gov Kris Bough, Ph.D. Health Science Administrator National Institute on Drug Abuse, NIH 6001 Executive Boulevard NSC Building - Room 4143 Bethesda, MD 20892 Phone: 301-443-9800 Email: boughk@mail.nih.gov Carole Brown, Ed.D. Research Associate Professor The Catholic University of America Department of Education O'Boyle Hall 620 Michigan Avenue, NE Washington, DC 200064 Phone: 202-319-5887 Fax: 202-319-5815 Email: brownc@cua.edu Kendall Bryant Coordinator of Alcohol and AIDS Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Rockville, MD 20892-7003 Phone: 301-402-9389 Email: kbryant@mail.nih.gov Kabi Buffington Information Specialist FASD Center for Excellence 2101 Gaither Road, Suite 600 Rockville, MD 20850 Phone: 301-527-6520 Fax: 301-527-6401 Email: kimberly.buffington@ngc.com Faye Calhoun, D.P.A., M.S. Board Member National Organization on Fetal Alcohol Syndrome 510 Holloway Street Durham, NC 27701 Phone: 202-550-9235 Email:  HYPERLINK "mailto:fbroadwater@verizon.net" fbroadwater@verizon.net Christina J. Cervera Intern Center for Substance Abuse Prevention Substance Abuse and Mental Health Services Administration 1220 East West Highway, APT. 1124 Silver Spring, MD 20910 Phone: 210-464-6964 Email: cjc-3399@yahoo.com Page Chiapella, Ph.D., M.S., M.P.H. Program Administrator Division of Treatment and Recovery Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Rockville, MD 20852 Phone: 301-443-4715 Fax: 301-443-8774 Email: pchiapel@mail.nih.gov Lenae Clements, M.S.W. Prevention Program Field Representative Oklahoma Department of Mental Health and Substance Abuse Services 1200 NE 13th Street Oklahoma City, OK 73152 Phone: 405-522-8783 Email: lclements@odmhsas.org Julie Croxford Health Analyst RTI 1639 Jefferson Street, Apt. 202 Rockville, MD 20852 Phone: 248-722-3738 Email: jcroxford@rti.org Kimberly Crump, M.A. Manager of Federal Relations Alcohol Policies Project Center for Science in the Public Interest 1875 Connecticut Avenue, NW, Suite 300 Washington, DC 20009 Phone: 202-777-8338 Fax: 202-265-4954 Email: kcrump@cspinet.org Dona Dei, R.N., M.S.N. State Director of Program Services MD-NCA Chapter March of Dimes 2700 S. Quincy Street, #220 Arlington, VA 22206 Phone: 703-824-0111 Fax: 703-578-4928 Email: ddei@marchofdimes.com Dan Dubovsky, M.S.W. FASD Specialist FASD Center for Excellence 2101 Gaither Road, Suite 600 Rockville, MD 20850 Phone: 301-527-6567 Fax: 301-527-6401 Email: dan.dubovsky@ngc.com Erin Frey, M.D. Program Director National Organization on Fetal Alcohol Syndrome 900 17th Street, NW, Suite 910 Washington, DC 20006 Phone: 202-785-4585 Email:  HYPERLINK "mailto:frey@nofas.org" frey@nofas.org Amelia Hall, M.A. Program Analyst Office of AIDS Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Rockville, MD 20852 Phone: 301-451-5867 Isadora Hare, M.S.W. Perinatal Health Specialist Maternal and Child Health Bureau Health Resources and Services Administration 5600 Fishers Lane, Room 18-12 Rockville, MD 20852 Phone: 301-443-9720 Email: ihare@hrsa.gov Lynne Haverkos, M.D., M.P.H. Program Director Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH 6100 Executive Boulevard Rockville, MD 20892-7510 Phone: 301-435-6881 Fax: 301-480-0230 Email:  HYPERLINK "mailto:lh179r@nih.gov" lh179r@nih.gov Josefine Haynes-Battle, R.N., B.S.N., M.S.N. Public Health Analyst Division of Systems Development Center for Substance Abuse Prevention Substance Abuse & Mental Health Services Administration 1 Choke Cherry Road, #4-1018 Rockville, MD 20857 Phone: 240-276-2563 Fax: 240-276-2410 Email: Josefine.Haynes- Battle@samhsa.hhs.gov Sarah Heil, Ph.D. Research Assistant Professor University of Vermont 1 South Prospect Street Room 1415 UHC Burlington, VT 05401 Phone: 802-656-8712 Email: sarah.heil@uvm.edu Mike Hilton, Ph.D. Associate Director Division of Epidemiology and Prevention Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Rockville, MD 20852 Phone: 301-402-9402 Email: mhilton@mail.nih.gov Larke Huang, Ph.D. Senior Advisor on Children's Issues Substance Abuse and Mental Health Services Administration 1 Choke Cherry Road Rockville, MD 20850 Phone: 240-276-2000 Fax: 240-276-2010 Email:  HYPERLINK "mailto:larke.huang@samhsa.hhs.gov" larke.huang@samhsa.hhs.gov Bob Hubner, Ph.D. Division of Epidemiology and Prevention Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Rockville, MD 20852 Phone: 301-443-4344 Fax: 301-443-8774 Email:  HYPERLINK "mailto:bhuebner@niaaa.nih.gov" bhuebner@niaaa.nih.gov Steven Jacquier Researcher Northern Educational Consulting PO Box 230007 Anchorage, AK 99523 Phone: 907-346-3833 Email: steven_jacquier@hotmail.com Lauren Jansson, M.D. Pediatrician The Center for Addiction and Pregnancy Johns Hopkins University School of Medicine 4940 Eastern Avenue, D5 Baltimore, MD 21224 Phone: 410-550-5438 Fax: 410-550-2713 Email:  HYPERLINK "mailto:ljansson@jhmi.edu" ljansson@jhmi.edu Christianne Johnson, M.A., C.H.E.S. Program Associate Partnership for Prevention 1015 18th Street, NW Washington, DC 20036 Phone: 202-785-4944 Email: cjohnson@prevent.org Davaadulam Khishigdelger Program Intern MD-NCA Chapter March of Dimes 2700 S. Quincy Street, #220 Arlington, VA 22206 Phone: 703-824-0111 Fax: 703-578-4928 Email: davaadulam_h@yahoo.com Lisa King, M.A. Women's Health Specialist Maternal and Child Health Bureau Health Resources and Services Administration 5600 Fishers Lane, Room 18-12 Rockville, MD 20857 Phone: 301-443-9739 Fax: 301-594-0186 Email: lking@hrsa.gov Suzanne Kinkle Risk Reduction Specialist Southern New Jersey Perinatal Cooperative 2500 McClellan Avenue, Suite 250 Pennsauken, NJ 08109 Phone: 756-665-6000 Email: skinkle@snjpc.org Barbara Kosogof, M.P.A. Analyst Northrop Grumman 2101 Gaither Road, Suite 600 Rockville, MD 20850 Phone: 301-527-6634 Email: barbara.kosogof@ngc.com Linda Kwon Emerging Leader Intern Health Resources and Services Administration 5600 Fishers Lane Rockville, MD 20857 Phone: 301-443-6327 Email: lkwon@hrsa.gov Jacqueline Lloyd, Ph.D. Health Scientist Administrator National Institute on Drug Abuse, NIH 6001 Executive Boulevard, Room 5166 Bethesda, MD 20892 Phone: 301-443-8892 Fax: 301-443-2636 Email: lloydj2@nida.nih.gov Cherry Lowman, Ph.D. Health Scientist Administrator Division of Treatment and Recovery Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Rockville, MD 20852 Phone: 301-443-0637 Email: clowman@mail.nih.gov Jeanne Mahoney Director Providers' Partnership American College of OB/GYN 409 12th Street, SW Washington, DC 20024 Phone: 202-314-2352 Fax: 202-484-3917 Email:  HYPERLINK "mailto:jmahoney@acog.org" jmahoney@acog.org Susan Maloney, M.H.S. Project Consultant Partnership for Prevention 1015 18th Street, NW, Suite 200 Washington, DC 20036-5215 Phone: 202-375-7809 Fax: 202-833-0113 Email: smaloney@prevent.org Kara Mandell, M.A. Research Analyst National Association of State Alcohol/Drug Abuse Directors 1025 Connecticut Avenue, Suite 605 Washington, DC 20036 Phone: 202-293-0090 ext. 112 Fax: 202-293-1250 Email:  HYPERLINK "mailto:kmandell@nasadad.org" kmandell@nasadad.org Angela Martinelli, Ph.D., R.N. Program Administrator Division of Treatment and Recovery Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane Rockville, MD 20852 Phone: 301-451-8507 Email: martinellia@mail.nih.gov Margaret E. Mattson, Ph.D. Division of Treatment and Recovery Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane, Room 2045 Rockville, MD 20852 Phone: 301-443-0638 Fax: 301-443-8774 Email: mmattson@mail.nih.gov Khin Maw, M.D. Psychiatrist DC Department of Mental Health 35 K Street, NE Suite 316 Washington, DC 20002 Phone: 202-442-4192 Fax: 202-371-1657 Email: khinmaw@yahoo.com Simon McNabb Office on Smoking and Health Centers for Disease Control and Prevention 395 E Street, SW Suite 9100 Washington, DC 20201 Phone: 202-245-0550 Fax: 202- 245-0554 Email:  HYPERLINK "mailto:E-mail:BOL1@cdc.gov" \o "mailto:E-mail:BOL1@cdc.gov" BOL1@cdc.gov Vinitha Meyyur Senior Evaluator Northrop Grumman 2101 Gaither Road Suite 600 Rockville, MD 20850 Phone: 301-527-6512 Email: vinitha.meyyur@ngc.com Laura Nagle FASD Prevention Coordinator Bluegrass Prevention Center 401 Gibson Lane Richmond, KY 40475 Phone: 859-624-3622 Email: lmnagle@bluegrass.org Kristi Obmascher Senior Outreach Specialist University of Wisconsin-Madison 21 North Park Street Madison, WI 53715 Phone: 608-262-8971 Fax: 608-265-2329 Email: kobmascher@dcs.wisc.edu Mary OConnor, Ph.D. Professor of Psychiatry and Biobehavioral Sciences University of Calfornia, Los Angeles School of Medicine 760 Westwood Plaza, Room 68-265A Los Angeles, CA 90024 Phone: 310-206-6528 Email: moconnor@mednet.ucla.edu Steve Oversby, R.N., Psy.D. Health Scientist Administrator Division of Pharmacotherapies & Medical Consequences of Drug Abuse Medication Grants Research Branch National Institute on Drug Abuse, NIH 6001 Executive Boulevard, # 4123 Bethesda, MD 20852 Phone: 301-435-0762 Email: soversby@mail.nih.gov Kathy Paxton, M.S. Director Behavioral Health and Education The Ohio State University 807 Kinnear Road Columbus, OH 43212 Phone: 614-699-4018 Fax: 614-247-6447 Email:  HYPERLINK "mailto:paxton.53@osu.edu" paxton.53@osu.edu Pauline Payne Addiction Specialist Howard County Health Department 921 Daleview Drive Silver Spring, MD 20901 Phone: 410-313-6202 Fax: 410-313-6212 Email: ppayne@howardcountymd.gov Sharon Pollack, M.P.H. Technical Assistance Liaison Northrop Grumman 2101 Gaither Road Rockville, MD 21075 Phone: 301-527-6521 Fax: 301-527-6401 E-mail:  HYPERLINK "mailto:psharon.pollack@ngc.com" psharon.pollack@ngc.com Carmen Ramos-Watson President/CEO QMRI/Celebra La Vida Con Salud 917 6th Street, NW Washington, DC 20001 Rockville, MD 21075 Phone: 202-347-9151 Fax: 202-347-9152 E-mail: cramos@qmri.com Drena Reaves-Bey, M.P.A., G.C.P.H. Director of Special Initiatives DC Department of Health 825 North Capitol Street, NE Washington, DC 20002 Phone: 202-535-2993 Email: drena.reaves@dc.gov Crissy Rivers-Crittenden, M.S.A. Program Manager FASD Center for Excellence 2101 Gaither Road, Suite 600 Rockville, MD 20850 Phone: 301-527-6522 Fax: 301-527-6401 Email: crissy.rivers@ngc.com Adalgisa Rodriguez Product Development Director FASD Center for Excellence 2101 Gaither Road, Suite 600 Rockville, MD 20850 Phone: 301-527-6511 Fax: 301-527-6401 Email: adalgisa.rodriguez@ngc.com Marcia Scott, Ph.D. Program Director Division of Epidemiology and Prevention Research National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane, Room 2067 Bethesda, MD 20892-9304 Phone: 301 402-6328 Fax: 301-443-8614 Email: mscott@mail.nih.gov Patricia Senner, M.S. Nurse Practitioner Covenant House Alaska 750 West 5th Avenue Anchorage, AK 99501 Phone: 907-339-4405 Fax: 907-272-1466 Email: psenner@covenanthouseak.org Candace Shelton Senior Native American Specialist FASD Center for Excellence 2240 E. Kleindale Tucson, AZ 85719 Phone: 520-881-8182 Email: canshelton@aol.com Belinda Sims, Ph.D. Health Scientist Administrator National Institute on Drug Abuse, NIH 6001 Executive Boulevard Bethesda, MD 20892 Phone: 301-443-6504 Email: bsims@nida.nih.gov Margo Singer, M.P.A. FASD State Coordinator New York State Office of Alcoholism and Substance Abuse Services 1450 Western Avenue Albany, NY 12203 Phone: 518-457-4384 Fax: 518-485-9480 Email:  HYPERLINK "mailto:margosinger@oasas.state.ny.us" margosinger@oasas.state.ny.us Lori Tesauro Perinatal Tobacco Counselor Southern New Jersey Perinatal Cooperative 2500 McClellan Avenue, Suite 210 Pennsauken, NJ 08109 Phone: 856-665-6000 Email: ltesauro@snjpc.org Suzette Tucker, M.H.R. Regional Manager Maryland Drug and Alcohol Abuse Administration 55 Wade Avenue Catonsville, MD 21228 Phone: 410-402-8648 Fax: 410-402-8601 Email:  HYPERLINK "mailto:stucker@dhmh.state.md.us" stucker@dhmh.state.md.us Martha Velez, M.D. Parenting Coordinator Johns Hopkins University School of Medicine 4940 Eastern Avenue Baltimore, MD 21224 Phone: 410-550-3414 Fax: 410-550-3111 Email: mvelez@jhmi.edu Enid Watson, M.Div. Massachusetts FASD State Coordinator Institute for Health and Recovery 349 Broadway Cambridge, MA 02139 Phone: 617-661-3991 Fax: 617-661-7277 Email: enidwatson@healthrecovery.org Linda White-Young, M.S.W. Public Health Advisor Center for Substance Abuse Treatment Substance Abuse and Mental Health Services Administration 4124 18th Place, NE Washington, DC 20018 Phone: 240-276-1581 Fax: 240-276-2970 Email: linda.white-young@samhsa.hhs.gov Donna Wiesenhahn Director Bluegrass Prevention Center PO Box 13670 Lexington, KY 40583 Phone: 859-225-3296 Email:  HYPERLINK "mailto:djwiesenha@bluegrass.org" djwiesenha@bluegrass.org Sharon Williams, J.D., M.P.H. Deputy Director Northrop Grumman 2101 Gaither Road Rockville, MD 21075 Phone: 301-527-6565 Fax: 301-527-6598 E-mail: sharon.williams@ngc.com Bridget Williams-Simmons Science Policy Branch National Institute on Alcohol Abuse and Alcoholism, NIH 5635 Fishers Lane, Room 3106 Rockville, MD 20852 Phone: 301-402-9406 Email: williamssimmonsbr@niaaa.nih.gov Georgiana Wilton, Ph.D. Department of Family Medicine University of Wisconsin, Madison 777 S. 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fhttp://www.cdc.gov/ncbddd/FAS/curriculum/index.htmDyK yK <http://www.cdc.gov/ncbddd/FASDyK yK xhttp://www.surgeongeneral.gov/pressreleases/sg02222005.htmlDyK yK <http://www.cdc.gov/ncbddd/FASDyK yK Bhttp://www.fasdcenter.samhsa.govDyK yK Nhttp://www.childstudy.org/FASDtrainingDyK yK jhttp://www.nichd.nih.gov/research/supported/pass.cfmDyK yK ,http://www.cifasd.orgDyK yK *http://www.nofas.orgDyK yK *http://www.nofas.orgDyK yK >http://www.cspinet.org/alcoholkDyK yK http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_AbstractPlus&term=%22Floyd+RL%22%5BAuthor%5DkDyK yK http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_AbstractPlus&term=%22Sobell+M%22%5BAuthor%5DsDyK yK http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_AbstractPlus&term=%22Velasquez+MM%22%5BAuthor%5DqDyK yK http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_AbstractPlus&term=%22Ingersoll+K%22%5BAuthor%5DqDyK 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