ࡱ>  bjbj-- 40OOppppp4wt, ppp1pp:R,;ҮF~ G0w.S!S!p$wS! 6:     Lymphoma Pathology Lymphoma Lymphoma a malignant neoplasm of cell derived from lymphocytes/lymphocyte precursors Sites where lymphocytes typically reside (lymph nodes, spleen, etc.), but can be basically anywhere BALT bronchus-associated lymphoid tissues MALT/GALT mucosa/gut-associated lymphoid tissues (mostly same thing) Other key sites skin, thymus, bone marrow, blood vs. ALL in ALL, lymphocytes/blasts are in the circulation; in lymphoma, they are in a palpable mass (with exceptions) B-cells more common lymphoma problem in US than T-cells (this lecture focuses on B-cells only) Lymphoma Node Anatomy Lymph Node Anatomy contain cortex, which has lymph node follicles within, comprised of: Germinal center B-cell rich area of lymph node (antigen-stimulated differentiation occurs) Mantle zone Cuff of dark cells around germinal center Marginal zone thinner layer around mantle zone, seen best in spleen Pre-follicular B-cells are nave recirculating B-cells, located in mantle zone or blood; havent diffd Follicular B-cells cells from mantle zone can travel deep into germinal center ( differentiate to stim. Somatic gene mutation takes place inside germinal center; can be used to identify follicular Post-follicular B-cells already differentiated memory B-cells, located in marginal zone or in elsewhere Lymphoma Classification Pre-follicular B-cell Lymphomas include CLL/SLL & mantle cell lymphomas: Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia (CLL/SLL) since pre-follicular B-cell lymphomas are in the circulation often, they are a leukemia in this sense Monoclonal CLL/SLL presents as excess lymphocytes in blood of same size/shape Caveat morphologically, CLL/SLL appears pre-follicular, but molecular studies indicate some are actually post-follicular. Pre-follicular subtypes have more aggressive course Mantle Cell Lymphoma cells of mantle zone become neoplastic & invade outside of boundary; more aggressive than CLL/SLL; irregularly contoured cells Follicular B-cell Lymphoma include follicular, large cell, and Burkitts lymphoma Follicular lymphoma presents as many invading follicles within a lymph node Small cleaved cells if this cell type present in follicle, less aggressive course Large round cells more of this cell type present in follicle, prognosis worse but responds to therapy well because dividing faster Large cell lymphoma follicle only contains large round cells, can expand out of germ. ctr. Prognosis lymphoma is highly aggressive, but this means Tx can at least work better Treatment aims at killing dividing cells, so works better on aggressive proliferating Burkitts Lymphoma incredibly aggressive, increased number of mitotic figures, often EBV association Genetic Defect most commonly t(8;14) Post-Follicular B-cell Lymphoma include marginal zone lymphoma (MALT) & lymphoplasmacytic Marginal Zone lymphoma pale marginal zone is abnormally expanded Spleen, GI Tract MALT common sites of marginal zone lymphomas H. pylori infection by this bug can induce MALT lymphoma Lymphoplasmacytic lymphoma induces syndrome of Waldenstroms macroglobulinemia Plasma-cell prone since post-follicular B-cells have differentiated already, some are predisposed to activate into plasma cells ( lymphoplasmacytic IgM secretion main initial Ig secreted vs. no IgM in plasmocytoma Waldenstroms macroglobulinemia thickened blood due to high Ig secretion Classification Scheme lymphoma subtypes are based upon analogy to normal cell types in lymph node Morphology some basic lymphomas can be identified based on morphology alone Surface marker studies most lymphomas are complex & require cytometry/immunostain to ID Pan-B CD19, CD20, CD22, CD79a Pant-T CD2, CD3, CD4, CD7 CD5 normally found on T-cells but pathognomic of B cell lymphomas CD10, Bcl-6 marker of germinal center differentiation Cyclin-D1 mantle cell lymphoma, some plasma cell myelomas, some hairly cell leukemias Specific patterns each lymphoma has specific immunophenotypes that can be used to identify Molecular genetics some lymphomas are defined by chromosomal abnormalities Clinical Dx of Non-Hodgkins Lymphomas Non-aggressive, but incurable CLL/SLL, follicular lymphoma, marginal zone, lymphoplasmacytic Aggressive, incurable Mantle cell lymphoma Aggressive, potential cure Large cell lymphoma Highly aggressive (potential cure) Burkitts lymphoma Hodgkins Disease Hodgkins Disease a clinically & histologically distinct type of lymphoma: Contiguous spread tends to spread contiguously from one lymph node to the next Mediastinal mass common presentation of Hodgkins disease Inflammatory reaction histology can show non-neoplastic inflammatory reaction to tumor cell Reed-Sternberg cell/Hodgkin Cell neoplastic cell type in disease, often surrounded by inflammation Histology can be bi-lobed nucleus, w/ 2 clear nuclei & 2 dark nucleoli ( Owls eye What is it? a B-cell, but very distinctive shape & properties Prognosis very responsive to therapy, often curable Subtypes classical (nodular sclerosis, mixed cellularity, lymphocyte depletion) & lymphocyte predomint. Classical Hodgkins Disease - Nodular sclerosis most common; lymph nodes have sclerotic nodules Mixed cellularity another type Lymphocyte depletion very rare Lymphocyte predominant Hodgkins Disease: Totally different disease lymphocyte predominant different from classical! Behavior acts like a low-grade, slowly progressive non-Hodgkins lymphoma (7?U`w|  P _  [ \ ) * 8 a o ˸ìáÖˋh h Z5CJaJh h ZCJaJh+ah ZCJaJhyh ZCJaJhyh Z5CJaJh:Eh ZCJaJh ZCJaJh Z5CJaJh:Eh 5CJaJh CJaJjh _5CJUaJh 5CJaJ2 w P \ s * b  | E ^ SS= & Fgd Zgd Z & Fgd Z & Fgd Z     ' S b c d |  ' 5 D E ~ RS]"-<LRg=P_v$hi|hxh ZCJaJh4`h Z5CJaJhDh Z5CJaJh Z56CJaJhx<h Z5CJaJh+ah ZCJaJ jh h ZCJaJh h ZCJaJh ZCJaJh Z5CJaJ8=iv` qKH&^` & Fgd Z & Fgd Z & Fgd Z|'Mgu#_`v  :Qpq{h%vh ZCJaJh/h Z5CJaJh@h ZCJaJh@h Z5CJaJhmh ZCJaJhmh Z5CJaJh|h Z5CJaJh ZCJH*aJhxh Z5CJaJh Z5CJaJhxh Z56CJaJh ZCJaJ.KjGH^%4>ju%_`jkʾʾʾʧʛҐh Z5CJH*aJhcPeh Z5CJaJhZth Z5CJaJh+ah ZCJaJhh Z5CJaJh ZCJaJh Z5CJaJh.h Z5CJaJ jh%vh ZCJaJh.h ZCJaJ5`D|-i,c2 & Fgd Z & Fgd Z & Fgd Zgd Z0CDi{|-=i~+5?Ouvwbcl1䛍h Z6CJaJhoX2h Z56CJaJhgh Z5CJaJhS=h Z5CJaJ jhgh ZCJaJhEh Z5CJaJhI0h Z5CJaJh+ah ZCJaJh ZCJaJh Z5CJaJh<h ZCJaJ112N~hTh Z5CJaJh ZCJaJh Z5CJaJh`Rh Z5CJaJ21h:p Z/ =!"#$% 4ZDd2%KKr  C NA6Disclaimer-No_Citation_KeyRnYbk"D#[JYDFBYbk"D#[JFIFHHICC_PROFILEappl mntrRGB XYZ  acspAPPLappl-appl rXYZ gXYZ4bXYZHwtpt\chadp,rTRCgTRCbTRCdesc@ocprt8vcgt0ndin8dscmLXYZ tK>XYZ Zs&XYZ (W3XYZ Rsf32 B&lcurvvcgtRRRndin8HW K'P T9textCopyright 2007 Apple Inc., all rights reserved.mluc enUS&~esES&daDK.deDE,fiFI(frFU(*itIT(VnlNL(nbNO&ptBR&svSE&jaJPRkoKR@zhTWlzhCNruRU"plPL,Yleinen RGB-profiiliGenerisk RGB-profilProfil Gnrique RVBN, RGB 000000u( RGB r_icϏPerfil RGB GenricoAllgemeines RGB-Profilfn RGB cϏeNGenerel RGB-beskrivelseAlgemeen RGB-profiel| RGB \ |Profilo RGB GenericoGeneric RGB Profile1I89 ?@>D8;L RGBUniwersalny profil RGBdescGeneric RGB ProfileGeneric RGB ProfiletExifMM*>F(iNHHC     C  " }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?~EO&2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QF2~EOh(?QEe6(QOȣi"e6(QOȣi"e6(QOȣi"e6( _#d~U{ggE/Q?*NE+Wiᰳ RUqSNVE/Q?*w E⾿8u&it ^eoaH 2I5W׾h ~$u{ֺق|5Ш˗_3d~TYv}-VT]Eqa- jfh8Fe8몺tK="[ 2)k}PkZNȌv'B.ҕ'}|z. ?>+h-l>*Xxxh >خ[>_z~)@NK$#%aE!UGaJn/ >_#7j_ hrxݼq\^i|NYIw7e J!x:O`խ2Bpq54R,%I)M;T]-ʏ/WrW~5kX -d@$w'99S֟x@k]w-n!מjqI a7? Iʌ {w{'bV-n%FTO5V~&6Z=,9.%#$@A'CCcq $_gm9Y+B/9VWCՔkkuj&7L Bfn2C J׸_#F4G~xm'kAuys߬N]F1-8$zV>{fG}qo=K=e,T3R;/Q?* ɦhWCCI{'| ev#Q=j߈<]][4K`rqns֋+^c_##]eOhj2J!)BǞx#5h6-1IPUpA&&c?*_#d~U{gg9QGd~Tyʯyy]*(ʏ/U/֏/֋E/Q?*t?*_#d~U{gg9QGd~Tyʯyy]*(ʏ/U/֏/֋E/Q?*t?*_#d~U{gg9QGd~Tyʯyy]*(ʏ/U/֏/֋E/Q?*tOIo tty92|X*5cៈ4'PK>h-/m[HBȧRAڻ_ ttyTr%$Ϥ[x*Xm'#DͮnBG$WVC_'B- o)d6凙4ҦQ@\պ%R?xcBsn. xZŭ5@iq 5ֱ4]/e+Zо_]&xSIT$aw'W^ Z_QGm;PvFKO+ ֢|`5}mWE]2z +t_ {WK4Kvso’\Vrm(BV9xS |QwHUm2XQ־|cc㷆tY޹|?xt T / /䌁'k_xM]I 2z+/k|#:ZZBM3֑x s}̹FྥHWɥYJӴv@|:늯h:^`ڦm}ȳ mzqU핬sZ՗M{+[dTGok7IEo`j/º,izU <3#B$l֬V0@$A!ܻncԟzNr"?<#E,t?β(=䊥fYm{$Y 刓zVԴӮtK!qe>ң88'1xFoC6:ީ4,3,XmQԓ\_WXtOL^-%efhr;i[VK2A𾴺SuŁ _q5tFjVڒDyʞzb(r߅R;@"XV1*/25h\롳,4[] ]f[%ִ>* H.CSע"ÜuՓEK]}+JK8h̐7ޅv<ΤOPhW)Jy'ҵΎp2|G}+[?@S'>y'ҵΎp2|G}+[?@S'>y'ҵΎp2|G}+[?@S'>F{V?:<O}(Oky?d'ҏ$V?:<O}(Oky?d'ҏ$V?:<O}(Oky?d'ҏ$V?:<O}(Oky?d'ҏ$V?:<O}(Oky?d'ҏ$V?:<ǑQ{~{|zjDfw܇̚9ƣP}OW?~?3'繼 |c(ҏ#U723CKgPo_G2Wux֘lCdYxӭAȵ!G2! d'NGh.Klf)Zx[u>@4 ^GGUCokkuYc>Eo3M;.R?#)c/ ~lO 'oݴ7#4q {~yߥIIH@|]0HYB{qGGULlWL2Kc蛿/xE/#*塻A0ʁsiapWy|oҏ#U_K}TRabߥG[^G:DGR9|#)j\!L7wMC'?U+ =J<:S?2\#V`~+fSVO6taQh 'cQIG{C| 魴?n쑀O5s9"%?-p]%ig+3^#{=C/TfI-m>?̿c=WKX3\_fri1/v.jػ[<,}co[Mi)T;x[?*\d{7 ?JY+q. 秔?0Z}YZM "דQ{~#]e?/wc֓0摨E$: .yߥGRŪSH^Eܔo֚ƎFWsRܖQ{~yߥmyƏ#abߥG[^G4s1|oҏ##{9ryGGVבh=9<_#+k4yƎvF/Q{~{O )ȕ\X3]JkBԊ~݋#TѮ#M5Vje1L0+z[ftEbPV!G4@pKHL1ꩿA(' /Oi_9G{C ֩0"/]x~[=z D2FF'M^63:M㭵KHOMGBgض̷L܀fҬqN2xZYT֑|-z^C,)E}t6ݭeBoYͨ_3`WU Yh֑㽶՟0?nQλ\\ἽnY2gӬgDGgغ}yM#cTW}!S$0 <.O@S]yu6R DA[_CKkӣnw v? G֡B\AK?Xb&6JㅌN5]7y/"[\]?mPn$F$# Uِ ^[7qcUчT$+Ù4YamkgOUAn'/}v4R2"+&]cIM'y oh&;dv=$ʮEx gj6W*92e}c={!_ɎҔY-ΝV[غWYy3T^>e솎x(u Nyk&?Y@mt:u~чoև5TL~)>qP#ԉc?ʇ6v UPw=?%GmuGrbwWܮR>T?Oi9EhTofAkzbwVeiЬOFS=e??)?5?Vwn3}){? N?9l|1ޟ}Cٮ90<*:É.fR[5 6ɲ|?jo˳G9S Bm6<{gT~MX~r4L1֔Ӊ^zL @YKM_T$c]c֟$SҖ#v㻢 WBjHWb'S?#01 USSEݣqrbJ~Vh_"H,N4.??j&MNkmne/mXz7v 7v*9bߦ >rV?بVj62ib]9(IWlt3aOn9Mʻ ?wtQj͑jRTr?!?jOt?{Z=n/l?v%5hjSڀ/50nRG.*3C}?4Fyf&?ҵCDg,O[u4QmCY}0}nm ?ֶ:{f]Ld^z);~ss}ZTKDu@|CXxCGo1kck/=(E Zi@y: _ȟy?5uƏM\Wh/ǯb#ڏ#ڢ?{_ԏWRֵN`M{Q~9Z_2{57e⸔rxwWؑ"O Zt~>Օ𮈧A?Մ4ɦ@:9݇+b>+OhnZS萹&iܴObQ*(€qG<>˧g?3@&Qbty?_ΚMl<ՊѢկ!9ʴ.=ZwY\iڂA':YP(az AV$D˜y^Z] ~L^[o x&eZ/>o\+ UV6j625"&]:Ա%MC¶6luKErJG5Ji/0WsjFQN]?[[Od1bu[\Ye4'/TwfhDv̾VkyѿN UKmu@kj^D5H~'teqn(gGdc^щ4''\~j=GIjMZi`ȿԍ#qzۊ4Re6 ?ݐ$'MOZPϔ/-Jr˱gJmn?)B~ ԇ({b_ zQJYSR= KMr&#k4Y7/?=(C Z_beߘ|/0[Cg' FykW{7!J} fHls͖6MHBv^w5s}{4vv4#mHA,sW'(62c%u/<74߻'RB6?*—߁7WjOH킉mn#Ld1'+)J6m[=PҡrٛdkA;$^Ƹ/|A[Rx-9 TkR6a!eC BH_X 4im>DLWo_/lR چ?gU[ߴg>yZtX"%X'XbX$|+4:A{p𖍜7b? hi덷Q<ெ>ukqKmdY% QOpKB _@g/ YZM&ĺ:>YZf x[h, PXn OR[tOO7Jm+X5(R ^lᑣfUTd+"]pH ^'Y ًOao ßȫ- o'ڏ'ڴ|cU&H?o K&ѓA'v>RG\|m5Z|[ontϡ$yc4 0[*9f׾)<ōgĶֿWHeeg+Hż…'j:#VAy[7m"yDI//Z=hKH"yʐOqRJ2\=0:*/k2xPӵ]-[i4Ph쐀SN;Y νᗆCxRoms=ݖuyee md֙㚥F\Ѽjy>գ{W4s03jy>գ{O_|!- _Ú%̗sOK$5xXm95f׬nC񕿈_ 7%}OKk'̏lff'iOkLJ<Ho R3uwF1Ik_ChaSs>$3g_{Y45Yt+oumoJ5.> s^-t!-~#I?ĝZO_V^ {;kk,RMbmQ!sw"4U_Zߧߩ?T]φ<1Mo?xƞHd&EKhDsYoq+L"|\;.v:=CBA/ 'i`}մWyc2<ǕA,ĎؔTK6R%5ouɼEK㧄#| .J)Tefyu3s n/,!tr+J{iŨ w%+",n908ue 99R+wi=O>ҾxnD,zV4f !Oު<:_5C⯋ k^?Lj%| xSLwQ^ROqpm$6T⢖U0Rnw_>  7UӬtyFKS|у$-E|2#] ~?_t oZFߺ]pV9 219`A(Y_ЗMY>>)n];PG;o R:SGn?+ Kڅvm#$ucWv=^_R=ർ,h i|_P (rחpϑ o#-xi e!Ic0 fFQO,d"Hj)Sӫ7o9a+k秏,]s+x_ҵ_jxgU3Yl㍮!H̫8_aeBx[NlGQЯӴ[% G5N[n(\QeYmnK'}O!ƍC@O[|Y/aKhMLx<љ0v cOi /_X|IxN}?-麭}:$aJ]+튧{iŨ w%+",n908ue 99̭%+wL=־"]C>QB4Ӵ+N+17wQZG$g)bK1ڃ|5i_?UjiX5ʬe-eA5,B9m[Γsޗ_u?qahkΰ#fhu[aR@\l%1Ú%⟇?AZxFK"Kjon`DLV1,I)s[]팾you"Qi ]ylޤ=)h6XGG-GG-GG-GG-GG-GG-GG-GG-GG-GG-GG-GG-GG-GG-GG-GG-GG-GG-QEQEQEQEQEQEQEQEQT,u]/S=7R$6mpi« N J08Qj^VI$KsgpF^7h]HʺHz@$FMBŵ[:gDǝu F Fhq42(%&GsxM"-J]V;T.ΰ;23#28 ӳ ?ښo$6?fW|OS"OMӮ4u B[kbms1Fq`ѓcNz}acL3glIpp^aQ@U=7Oo 폳}>zNo7|,( ( ( ( ( ( ( ( ( ( ( ??Jլ| ^Om2YL$n2:0 땍?-}W6cQ5>m?R24b{yhMC.fRҔf2fHYmZC[^I\#.447h%%eܬI$YV?S$Bx3m O5 JH F~ DhWT4bW][E4P:,*O(>C;W~̿,5^/PjWRXHLqڴYFKM[׷Kݭ8~/oCɿkOo]_ .[_h:v\hƇjLb$,,xtoZ-u?xB[:^Mj.10UW4ٿ&пAiv:ES1Mc!i#f8E![Vᇈ.w^_O>-o~64Կ+Sź?VqMCk#w0#YJ8SBfG/"5_!iW^4]6'xI>#Da5XVxn쿻k[wعʨ<>|)lEnk2Mbm?LeeKK9%k{fev kGøӲu+U?>ycK9SNzJ<1h|7ʑI4Ilvq+tU߂>&\|r>,Z~W2>R4fߢVYIaHöˇFH5 >ȯ,wn5ۛ 1 55:1F+0 A|1Gl5WtACu^Z1, 8Jv[t5}ߑ><훡wŚx6:Ům{{vEZo\Ʊfyc71ۜ׀xc~8Wzi&e2( aQ36TGmCgďzIfOCsN#HY4Js"aۆÁ_kixnG=]խ$IVkdv$ W;A 7a@i_ g<#km7koڧsq` 9K(iw$xzh|)Ыoxܞ(ݾkxBR+W|9Ty(y,ƙzeg?5oIկAO x:՝.c6a~|yU>~mȡ[#mGW-KJKf5-:Xj /^;fIcѫ6"2,|9]mDM~&Jsnߖ㈤'ˣ}ӡTqJ.t>I{ğEcY~"crW zT| rG~=Zuw[Ǹ<7`%&6smc8cg#wH2_3~ >*M 13Sj˫gv4oԂ/+\7y-۾lj_~;}OOwf>t-' "yq~ f4;Lqu.ש}MW= ZoŞ3ll;Z8Dm7vbBeD|HӼWؾhgfӠH0dV2ዐʉd 7X| _c>ó:4צkJD1sq+ǖyM_pwcOiZѵ?/5CPh򙤚*j%8%k//=6z-ƨM6o?Qj{&85.UN+Mh6ȡ7ĩV ]KHmGW46eswy/#c-,a)?kѼCTd-:M>v83~e$y\ׄx/Z:8(45f6PMkRD_^2_wZM1I'lU HA򻻚>w]ML3y'?Ÿ k>x?'-kXG$z6#L!v8$fy`dT+$I۝63xg[Ծ0xJ? x>-CXmm#F#.ʼnw>|?ޡ ÖdЌ37 H< tvhaeJer+ch7軿E <񗍵υV~8uo ~hp\@CsQŒE}+_ĺދNӴewxMڝeVH,H|FS~7ert>Me%c]N67mSF_vC.Z_Ѩz~~$|BѤxW⟉gm=Sܾo ]DЙeu j#f9Ivo|»ψč_x _#Rֵ}"Iowe~Wss`Wpb׃>|6mu ڜwv-aC]#ah-#DLAA @e,7xHI-&fsۊp51|< oR-wn䳓 )up6Y~~.9MpAkl<=4[ ߉utfU+)n ĊR@ϙo{hLeo{~_O HaHҘ3)v(x&j{os֏}*wO$M| * `B 6澪~F3xV0k_%,;E@4c` MKởU5{4/M:^Ib%8e njoO__b_/oY?߉1x??A{kH񯆴5'TR k{u0%f%R۰ Wؐ| ]i;i l1}&uuf3\tHA&5i<|#_dž5ӤuFM>vrO4$rf,TbPSazdwfrY_[̺o_ h;ѴյߎZ+f(:Y#iƉe*_!S֍H񇇿i?G5oG;GOocrtp7&w-}| g@nX]\^{c{츚+&Ib/Ȍ6#~[o$_~UmMA?Nd 'NdíZ_"eľ(lO/|4-<@0Os pFwȨ33_8FgP񑰓gú|zZgYAtoK*@`ZGz2isw\ϩ[$@oY€)Sk=[c,o?Pcxoٖq-ngq&0z_K[ߛoo/OYN5-Фm6IUk¾%|\|Z Nӧσ4=!tخ#MUKI|P~>(?Tft,Մ*'K`Ь +m ]6;cÖ,ҭ̒IBWi@q??^V.]Z}w[^?fM!1# `(--tWxzg?o Guj rYg46}3TElg}vȌP go~1>255K*Edh!~rCq461hihhPiWYy "dcJʵb7TO'ްb)N6mH֍)O,QEtQ@Q@Q@Q@Q@Q@Q@Q@Q@y-{>#x‰n"9yw`#X8Y̔pJ\)RSr="v'?%ִ:iK2. <(c͌w ٚ)gk#.H, qk,//[6JjvwWx~ЍH$6ypA :IKKO_?gtt{̌rJ`O/TfJе/xΙ%׉+[˳$W/P,~Hڒ3".U~{ | OΰO,zYj.%F  UprO^"?m|yɪOŚ $K .!dd 4撖}m/3Jo/$iW//x˝O<Ew%Im#Le Bd'? 7eKr4)XZH->$"ՕJ/mC{cV7ƇJñYˍ>lI %ûdY<]~z?%`П;3[ho3x߷㢖 Om>}rr˷n' ᎥSV:u_YM_oGM|M/>-3x԰hXȷ e4Kq^{xCtۍR?|5Igc]Av]\٤Agv/&G+H fھς>0[}6=/x{BE+qj.L"!ޒT629|oJuRhiR[NfwYnB0S9;/aMMy_˽ryjj_y?tڧW4նmfS˸[A 4/)R5;,૟ >!;oeV{qpאGQ'6@o<]Qf]V%焵>F7M,2 &xsFߐ5vŇ W[^hזb+Μ,\~GZktdwBp>/ÍJ]KCVz2A*r  $,1h^ s7k 7wv6_iA[J^֝[<15( aуd7&h~5KV#VoڏIԿfL/M iǤf+:^̐FA>K{^_?eu/JmN]B;lE)-дS!F4TsOKdž!|uh/cu_id]>3 !l|KV{7gv}_W|0$mͻ:0YumoӮ抩1oMlN|Be&|mu5ZX}؎X;dc)̠ Sڿ/J^ُmn9)c"?.LvYB(b®gCƟ ~.j? u]gsks.fVDtD%|͞8$߲~/~ռ5{4]mǂ Ӯlg7/| ]8`8Tz7&/ʟl/ |@I<;xL a%F[|=2`Hc6=/K=U'Ilmp hi6 FB",_oO/cFݡ^/Zw! OQW~o/ˏ=o\ɻoA*O/W}POq5@Miucw<ڋ1D_xF d-&7]RhT|=A?Z'478$t%)Pm'z8c;xuƹYxĞ$BHkD6q[,CBT6#$(v[ /^+?74?u|>!OۛYgXtt_"e+vpnqZw쮾N R^viⷄj-]W½"_gr61,>TI;@RBCx|cj]Xl$PD Ydp, @ᖡ>k~'v|gjMM -*i $6«rI>S<1(³~W_XU^ 5]2}>SI䬀;A\iZk#LO3}붿uL?>&|3.K hVfYʂ(ţ6&.~gJ(|_d`Jt_>n~?[LZ$[E#y26r;NH^z5S7Z_AԵM9W .hc@ ~ɚ?[WŭK6x*~] >M>"Ye_ xO5O|S x0nQ#Z5Y%Tl% , Ofm;^xd~*>i6vOe$;]H`F"-D}o?xKA|x O#2E~g`c=b'><'>$6oS֒H./;7cg2r 3xY|fj/_gnZԖ_)}}F+˲?Oş=CE ~ j~Dwm;8QKRTX˟5_IյM;Kw]ܤHA!C1qk| ؿj5߷a-N9r-e"/Sg$ dtP`jaUmnyKdbaVPV~g!/SYV_J·-E nnY6[T2 WTi? ki'KmZWdxwW$1|Lp+_vo <__Uՠ[2iyÀx$8n_ ]$ี>j/9YKpR;%,J2glLou~}OYwßxⅦ'{nI.ʓ&61cc)ix6s^ e|QuOjCr0T(A ?dV(u>Fja;Vg1oNk1ӼMX+}CI}By'b,;XX˹鮺vm]~=q24xۭ Tj7,! wWW2|Ui |D szO}Z("dkdM}_ ayR}KW؍rc ӬbXF,Zboh>7}f>wíC:%3H#V{VH2jEAFg/ڭt*kow|5i",חg/-no?g~~$c5׍BDjf9,p ;Ec#+ȾdLq|$ȵWßo1s:WO2m4uu;!bo4.yf*V@~ju0OOm Letwiۿx~"xHn-gJo+R˺î[`xo-O>9l.goPyI+eRr[8'/>#DHƍDq-ݯx#^%F/fғR -D(ьlZM6i(֕ ;^g[↧::[|:.$ D[^;9d ;VIզqmUx '~{>x \?hB-j]\+3 k-wǞ:'^h6^*iֹ)IGbܞHs'qm6mmyRWV/-LEEPEPEPEPEPEPEPEPEPEPEP\?|ύj y{vٍ8pzWa^sAռU#SƃisXa[y<֒nrrX3-MF]Kt5 Ag2%̥F@7F|e/x7I8Ⱦ Ki]]p q^=cQ4?G Q⏉>=mmN3),#$dSMt*!Xsj:eΥlMHLm';3_ǟ~27 xF{g е42Ke0}7q!bq9#+g/xCu7o x徠];Dm2:- xU'>WK.MrNƋB/֤1:j apHe,TeH w[ßt:_Xx+R`vڔmox?,LB䍭=f?x^3 ߂oek:E٭U$(3 |> ~~)ִK>Եh4?Rdyc6-s@$ S/W -:e?Zo ~ 76` PAm9& !x7/|uumk>0ՠݧ[jOgrCL"D,C V>~;D^k_Zu݌O:TkiD% Vƫ ]<j)ZvwxwJMޞt6)3L F5뿴t3P F>)ӵ uL=F@D W/ϊ|~)_ X?K#Iui$.. jф6D%t?g=||Tۦ;oSExf]W,*8\:WryUdqW=:1d4Q7!#,dal~wÍ:N tOYYͷP/_ɷGl3_W1xKQѾ!k:-Ke>Bމ&PmUTHʹ<:.vpwwӪNUO%xqxȑd5 Ď"3Č0yjw~*C5O@FeDSυ c^(3.|K<~3O~i@]D[7E\O~N½c# |GN8ṉZ4<ۓ82 (2ĭOըߊK?|ϡWĿ|da2U!t/^9>m׿UȐEq8"ς~KjH;yh5;גEP7cFSqNT0ɻKk^(ժ_x?xN~!K]֯~eiep_v`3?ÿ|3 k~!6&)Lq FX;OfO [諠WwW涺cexq\$^|K6ؼ ]ՇoM€ͩj-2{b);LI`娖?[wV_􏅾6|%-? |B5iomg|DYGڮ$F*~,54#ԭ7[]f>2Hber@"vGh?c vu%K]2G>hkQ[ߜ S[x7ƚo4O ]Kk^7@Ak=\%Hd@ xj,Uj>şu; /þQ%!ZR:@ io?]:|=imY-LZLIpdX]}s7Lg >k-s7MΏV]e.L5x r?<~x6 k;hO ڟk(8 ( %X9n寪zRKFo__x<5o~ U$t:r3Ey=yw%|?ai ޱjZ0ҰP7z~;9{+]g,՜iA%Cؼ-u~RO|A $71z|;^]Aw#1 Cl),~l>BJO~ͧ$}YWᾗnz7e $I}'!?P߆->_xigzwy yyߎq/<-ψ^-/_'n!KQqa!8Nmo| a⸼]*oXؼS<SmB;틕Cͬ!cֲWsGZ_gzOτko-YaOZG-Ho1Bh-sWt? $ 1C_)>;ύxsž7 [yrΒ-IYl8|.tiŎ<aᯉ bYFe:͙39au~ՉU>ݷ"дxTլ4}FaAw & /zϋ-<{"TTD,i"Y.F_pۜ|yV)ω|m.-wO-ZtL$AlA"lX<"/|~_촏G\&Wş_x8m䙯w0}SPiaN7si:Oc^s?k:w-|;ipZ͉ qKWR7G+BS޹|fkw὜ OƤll\[, 2FT!>og¿[`|Uko@nGY^ߛ=6I~!@uii0S˘HW_?<}k?RxO ?lu h֥y&0YYQ7uٝ]cBj(5w"J7_S߾&xOELҼO\˛ygtK#K衛llꊸ-YҧK߮o\>m?\.-wߏoLS(((((((((((((((((#z>)ciWš^|JDŗ-fq|s7 QVM+z#[oXQ?, |GB=E9`_|s7 =~?_g^1?, |oX<aG+?z+?Eo-7,(QusT7Om^;fK 2FUb*a^K?, |oX<aOA{=|s7 ?Eo~?_g^1?, |oX<aG+?z+?Eo-7,(QusEx"x/ E9`_?οw3[oXQ?, |GA{=|s7 ?Eo{(:9gcoX<aG"x/ e_;WW-7,([oXQ =E9`_|s7 =~?_g}x^ x?uƕCk%P\k?Eo-7,*@z+?Eo-7,*}~?_g^1?, |oX<aG+?z+?Eo-7,(QusX{@牭=ۥޫkw<(rodSRp;W-7,([oXST9_{=|s7 ?Eo~?_g^1?, |oX<aG+?z+?Eo-7,(QusEx"x/ E9`_?οw3[oXQ?, |GA{=|s7 ?Eo{(:9gcoX<aG"x/ e_;WW-7,([oXQ =E9`_|s7 =~?_g^1?, |oX<aG+?z+?Eo-7,(QusEx"x/ ®|'i~#h3moSϋb -K.\ 84:K$CSX(,(((((((Yg_(9W~;_x.̶){; yT.g7'd_mbvb0H8Q%u?z>xb%5}?OHkI.1F 5N|g<̤m?jߊmg6j ׮t -BHI$5[ypٙQ[v uc osxAWVybG<Z'?~ Mxzp2M{C$Ѭ l$X;o^xyE5dlqC2&2x^?ck_OR#^kNH>!y+b=5i4֒/1́TODGm_Jx;:|=ApV_,7VG4:8#q3oQ\vVD6 [$UP ,x rx`'|5w|-,Ӧ]Rd69.6sZ^/^iSǿw ^xk|B[xWrO,0lLp 2$mσeK/IxPMXih`MK#]C7# 9xe5\?#{7 *QT `R )&B2FOj:oZκ%-''mW$)j֧^tjWGgu!6ie-f435ڻC@7|9t-FWu,6f*3,Cȶ*ed>״ip oA[Ų1"$E*nOA5=߇6Ɓx uiz\I8̯*Ht$rUz^֚$޾OM Oؿ!׃iB+ j . <ʄH8\aƟm'^ 7/Y4o6aޡ2]imh$ /iάUuɴ[1x_`n''K-?em-oI[tڟ_Vzz]Mo}~cvo]c˝[BoO4/vK@MΝWY|Q/6I0FȚ$g.h)HʃoFTw-QksߵK_Ҵ CCOT"eB"|4C7O75 zǬZص?iKm-ۅcD;P7>g)6&AڹLxiR} 9ߎ,|//xWE?3ZӭiMk백,k] #c|lG|frn74xIOPa/|Wۄ0@#ЊZRiN??@T&bÝ8[PijwϧOL~uͬõ2~/xsTSI𭦓{Ni)S[Hshq9#+|{91=4_Þ(|csg3Ik>5ѠP#IUco]< 3E/n%]?IQ' pYsnD`@^%?yAȠFUYx@ۛxbFLfhYUs jy-O?Ěֱ𵾝iw\G3Ng]| i5[Zz)N)0W"UY`V;xS0B~⺵n,x)w, w+σ= ;49*]^+TxnkܵI"ʳ d8 gq([l Z\ j>n291/ڷog±iuh5IX^y>ncU/xwE%k4y2ɯ%yFp$ c;~U @Zע߳ӵt5n'Am<>Vuh߼W-֬ŲWqiGd0rHFF2ޫ⏋~8Wkt[]xoMc=. ʊWBP9-[S^J??:l?m_C~/6Ku{w.",Xt{g=nA_~9x/>ޏg ìۛ洼K`dʝX̒41M06rǩ&LMEҷpQ5y~uZ_gBk$5]v巸F<0" u7~mƚn/7^Ѧ%otJnΖQ# 6`g ⍫ѸqTt[֒O#'> ޑa"-wY$ǸGpĐ5zÿZZ|%,L7I}bku9Qiw斄hi2~ڻ6m1( H$c8&^{R4׼|~_Z<#)<;g.p] |B4iTy"]!]Ӽ[Hޅ B=6;G:٤AҬ~rŕW%6RpɫXi~"5???|jxn"h`sxR bOP sqio?j[Y_xQtn.f{_ЬUdи)H;k>G}t^§xK>/,{p 4N)~-rj`U!Y9ua >.|K|^ԯ<#\\ K1Z-8&{KE}UK :V%;?:ioi}|Yª8P2\St2[[wVO3Y5KO[7ėtolXWKˀʬ56qIo|Ai'D𦿩z9gl&3\U 1gP~OvUT1ҔT4ҵ;|4&?̻yo |tigY.ki m߶t@ F[hF $TA^J>)uɭI?I̚~[_%^Mm= Y '($} ײVd6knOWcY!F[2B5\eI#x&f c+>QeǤU'Oz(,(((((((Yg_(9VwoW&xGZ|+>ŵswo6%$>SBD(ѷ5OK?eG5z(l6cȧ̟>cimDž2Jƥ";NV_ۏ(Du t[M,iep e6&G~D}Rc> FxcFDмw=Xǧ M*O+]5\I#m[`j^7#oaR2fL( 7cBJG g~~ї8>)ҵkF,-bduDԋ]]yƧLYݾy^NunMSNS qc/!խȞկ69xB@ʎ7c _rMc6HO J[cdz^,Z[iF3Zpd^Z6Hl6~ʺ.<KĞ6jxL%o$2}>68ڡkz*bRN>oIqL6I(am:쿾IF:Q%i2^ԭun+TKk#k̡@y9!w3ԢWR{Fb]B( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ?T~?E_1 c+z_?TD(]g+Š(((((((%u?u'|_wL_Oz:thI44ѪnUy/Yg_(9W[G"'%}[y''KeR0 CَV_mVͧ>ˣ*]mX#m.!,I+`T|uK}~oWGu-j_R+yιGTѼY(/ ԢJk)͞v`;lХp<t@꺅妐̈.u;BO0 |Χtztm_${K}F(i[Pfr:PN|'d#ԯ/IV%Ekm5艣MDPT9W=v\d^׈>-[ZW5MM-_L7SZʏlgF'@,x|KZxRo _Sk.@ 8mwfl繍̭@vhJ' X}/r: :H׷7cKk;Cn_J]X#1yZMo=+:B$"]B$[f7akտg kR׼Qua,YKk nKmZgEkrdݤNs*m,J4uǫhpij4<@a"[ }21Îj վSx𮝬:}ͪg7߹ ϕ;|UuSDӼ1[ITa0.Lv1Qd췶0v|/Yz5xm/I+ݥH.$r2\R^-rxͶ[f iDX@BfʀǸ|oÿ<)]{@.!lK9>=%㘍HBpy;[o!߁ ƹo{Iw՗QE DM4v47UIO5/t}[\9i=K<3#%hN!|PIqպ+>)':+e"I-Mچ, ;0\4% Bxd4wQyn#GAq?g¸·^ 㷷t0XV+;##-GghǍ|gk'Rxױ8TX,B Ma+ձs[+V4]J-cU5{m9-mf6;mڻd|+_ȓnv'È)=G"*C)y$ G &@c)j1Ο@u+I_5-[Bž=rM~wFP 1OD#iVuM1X^:l71–[ŧ˝i ū mد[CKÑ7u4o-%…C&01Sj_<-&PWJ&MY㹚-B & u9UͨjiWq!Ozkյ?ݵ%(cp‘)bv%P{7 ^~-=./ 'Mnu{ g40V Iv6#~(3VnjuԦt_ MjvZ["M @ zsЌtco;k5_~mjWQN%rpjZ/_: QIaGy!H%*Qd_?F:QwF|徫}I["=oV^Yj;&ѡiE,!ccyWOeMr+ļK'ܿď]F[O%mO+##ƌ>VVݖ7zό.-flmC+K<Yim2mi-1Θf6x;/yOϟw=e>-|8FMP]}T:$}[VPbyO藗^[Ym{86q} eUIfUdR` |;yZKqh$ׯ4-Mxڥ$%FrHX5+ռZn.ۨ>ֿ S\ۢ/EaB8^'_[~$%o-UΫwj: #Aa%17[1 ?)ᖒ4 ?TPFk+K0XUc y,r+ٷVZ~-懦O>=%PlG\]ew`U>=ܿ |U خ%># KV0J"kWh=-eFwkXSI95"%,BWϣ:|(.u5/Yis wVD`dPң=ۜ\7j/<=}N/Yƣo-P v,pY*쵴[|e/Z~-(et @Jyg x#=xK"٬.]Bsm|0SA"[W+ğ~-!>%H[/Qe О he\YJol&'T"dP嘰[EʬLu!{${+DJbc[)xšw$Fp(V9^!DE-#"PHݔ⮝ھe{J$$$22ho|? ֬u Kݾb!LTOp,rF0d<`?ƕa/ #[OSӭXEa-3.E\B'*ZaSz鿸 1a&l0Ca<>![SԬtZ)gy ̯Q M2`yaNH3t#övz:3[iz]>PEy`G[I" ,K=?-OZdm K ۶鄞\1qP&ծ|cf׼o5{-Z[h:4NA&Uٙ@R yLjK+m?7fJ]_Vh]YDщ(|nmܒl( _nTi]r2}<_wQሼ{oceR9h\<+ɽYDq4yi5O|Yĉ_I5ޏn.5;Ӵ,-fbQ׈-i7[(X.Dw>6I☮WA_aM;Z6MXo$5d-'mq+p4u&ɽkIy7$29**g**")ߕWE:Ngψ ~`-,<<—ae1 {n#j::֞.yhum5 j:]孇dӡG,^֤ma2)躆wz>w/}5p2]rry>ZKN1;k#oIЭ?5֝[꺝΃$IԦ)6V6L6pdr̦~Rߊ?ixsO[8K}׷YVxfPBEٕ+?hExxSjie+JUp=(xK%kH`53ShRí,w[5+9(<( 1_5#*W!xua;mqHʱ^vR3[$,1f˴FĩFܨq|{3V*|BдmzçKi^# xlg\hC4EnR62V2(h5gOS]jr%&"b3m fBEUᄨ>KoƷUA> ZLw=)剣C[J 4ytY|m_ok)g^^1OK?eG5g/k7-#z>q]]j&[+`uVg| /%ݴ13#ڨt|m5]O^[PuK*Dq,* j?ݷ.4KhtB['}}s8C%Y<+RhdwXi]X_Eyel mZ[_]\\lE&3  w SpmWG r{Fieuɋ_$$;7Q_Tt/.Ɗڇ(*x‰V^3G&a=$ʁ7kXbqvBiޯw}kF.4K䉉WUeadw([W[\{=h4]g㮳k/w{sK,=: 4kkvrOF[<8(Q-޿h:ESxUtۈ5' GZZ[U5Z6r{I%џb_l|f/5!}×CŧEXgUэʴk?̡X'2jVRZw#m?SuGOiw M0icM4`_2,Bϫh{|_ ?5!kq=+\YJV ^'X杔3Bd; 7xo4M.]"|htQN5ټpn4D}R`Z"ow0rt(,}aҴGE 7Zhg{"UyKi>Ė4RC@];wcVx?:ŒV焢+8(+兄wIj>Ȣ >%:lj|zWDW6&{qre#t7lACkſ1xZ<7sW:>$b{{>y=Zܱ\Y|oi\iY}E|#㗆|_ŵ?ir|I5gҴdGL.ccy 7o࿀3jf{sOYw6i,/%0dVO,1wn JE,JwџQ_>%)MiZy `:r+weuQ<M[⎥%9_Y@=.<7 fd68# I! :Bv1*]񕮯^]K36/ڴ^&y B7Fd 卣kR>lZmֻ?f'MVvәa38HyR<w25+J4?.Y^6soC3<6z BVEYx.a |?m;;N 4`y5V ZTq "8Y;귱NVſ n5=gH{[ ae>m$kfb/X2ft\_jtG%n4OyvUI @$ c+Bꄱ >%ҼU]ۺ|Mame]FA5+N*b޽O|Io s]uEiiKiH|KbI6`J-+B5M+{_tkz\:_igJAkeoxM򹄩TXfȘId1z8i"[jUO[inG-ktdLsm3˂CKv^xeXlGw4;Pt%_)[Ow ,xaY`,nI:O/]|gtKQGyɓ6<2ʝ%Vv͌dRr庒/+Wj2si~ YjB .EYHP{<\H𦁪Oacc,.c*G#FH~WaLLG )hx`_ M㟎xGoRXkυomeD]!}]&7 GMV9abOdͼ9<+ƪ-nо3j+Ծ)]k:G헆\_jkʒ4!B}--g7vSYxI..KR.>I j)Y̫ y"SIe{]V+?|=>#Ӽgq֗|En 3k {mm^a[PeHv2 O,xFg@49tRk{FkI9 #m썻HAEߔjx)'kq,B}E|u^mΩ?D7ھ38-em \+!tl$|Vt=";'ź1Z>']̗W&ְ-%=Ѥ_>+n ZQ_x?u][VJ|Akx;1,wQmJCkYQyeO\o]m%W3-6,cN5 t[8ZC,X+}wE|xŤZױKk_IIuca*3 6NgL.kv_eF-3g&3^Ioc &GK'B~Xv$prn@ -诒e%ii›à'k%aF#,;UB-{_a :U귺wg A pH"{]_,K']#T=}Ѣ\/OGY''+O1$9+Yjx/QqR75=3E8>s$߿7a6 # o Lά7*}ECh^EBHKyT)]YAgVU:{(+>QeǤW׌|)*H|Qt=( ( ( ( ( ( ( (袀 (G$s@,NѲ Pq $QU~((}_JRjz|n%X"_Y@I v`QE ( ?T~?E_1 c+z_?TD(]g+Š(((((((%u?y(?υ(o|MGa^hnQ\{7(c.F mqmh-lxuz;xgHsym^R:U+(|Uo9:V^"7\ķw>`Jc;4P.|}k> ZM|OqZQE9T"%1i$,=vQD ŗu+;?훑t8o< .9FW;[rwuwi"Y]З|66e]>X^z3]8-]3XEyNP_VrIyw}%ej61Z˵K5?_~v(5Ex\hW&V;#FA,r[5Euhּ5ii6sċ}S- LGȄtVϸGºsvK= X4[仌V'Lm-s,@ tUT⟧m{jGks7CGzቼwi/Dͮɫv1,g?h[,ImB@p?t/Gn"xG<3}X5ș5 GDHX+7swx[ -o)LX\2L\"~񿅧 ce .t q4k+.B0V<ե&E5妒\_P⻿z|\ZHkI qnQ m 7|4~1x-NFI/uI%ˑ+y%}1|#N"Go_~1]蟳<&>IfP)33J SSyccuoL8~Ⱦ%ݩCJ{jDbnҭf,Wn#FYQגPZ@NOY? źoĐV[^Ԅ@H숴2~[fß~#xI5X\$ `k<22Kܫk&LESŸuة~(xšNͭͦYi6ڣ2]k8cy -يwED߳^ 5k=jPٛiA,|i"9gŽt%{+|OkௌvڍΧ75е3K}r9VLM%@0$8_5Ž࿌z麚^ӒOn&-d\\-5paX3kkCIaÝfm IT]^v891*Ercsf]GV> ޙ^$ad/$3+LѰ-H_2\3:ψzǻCGul|o K=Rฉ/Cb{ 2\R۸&dPaм5S}Kf~PP }6 w}$nJO!LOEV:fV:xJlO*[KS w~ƛh:/' OYQ2` pyTr|tK~ƭ/X>v!$9![D 3 i][~P+|1Fڋzτ-5y`ԥԭ )R,g!Oqʻm 5\?M_E5“g}aәi7t4G5y^yˮ/+4DTڝfh]Gm/ykJWK_I%?#kL<\&M{qa{6Aq#O)vO |uBnuK[_i#[ڝRYkNy|if5!;gCnO >[Ǎk:TCe6buh{_)YٗΑ;_zV<麠eڞǁB>Pc_`VǮkZR$jCwbwx;eҍ5}3៏O xNvIVy<مKFUYo5 ~> ,xK7V# op4䬊C"Fl-+yzSzHwMNGY־ 7K :kȝmPqLby$Y1 yNlj]jZ IM}R$V@F^ ;US'1ʧt~!W/*w_1w+GKs5JfL~$g kxMt]Ǭ?⹺{th"yΉ$1Glv9򦢺?,/<<#SKYkOWX$a:SI"[U:ZC 4N5ww^x[ O]U0Fk" cm_]Oe{ iIkm{2+XܺPnp9ɮ_fּK_ >./΁,*c!>p٦^*+ĨngsuVό44bb.no1oloǵ@zGL> ?źխV.`XdVc#zG㞥kvҏ 5gf#6Zkzns1qq(Kܿ;i]y|P<9.yKvn@hyWݳpRFD]*\}x?.X?jM—dcI-+\7cH9VtþT`Um(xS#4]c[aԜ+˜3Jb,X#$>jkeoaZZ3>+ZvV= ]!ֵX]MN&DfRB!0y>Z׌b|JO{ZI-/%k4@% M<FS{vC{.M]׆.WO/?#ێҳ< P><S]kM!5@XAc&Fn ,*[!5ME? [97E7)6}j[}X4f;ٸBW >:Y)SkAfRz[A3 \j/̃hܛ0h:6-gk0 `ӡI EBQZ42럏m{ /[kY<ޞ?_|^ּ9eO[6O{ zs-ipфVgg»X,+Ӿ9xn?kӓGImH?ْ-N12j Vەi%{ݖ-#q9MxdzO)m[Q{mMFFPIňkA}&ëax:t,.]FM8[F[Ps޵<V?__Ҵ[ݬKiAwQ[te#P0d;ImJHғK 'Trv߻fރݼOSsa.XiZ.Ӫ I3hmr]Xm;_Cĭ_:NUof\Z-ج^PITH#+,7xnk :Ŗr$p\eL,dLI25am[zǛ띗H[m|?Я.MKIL~{}:Omq NyHD#^hZ'UA!׻x㎠_Иi{qu[xd4#Ri1 Vw:sEGc]݉--o nid*>$A-ƐTp_?g%M %݆M֤n#֠3O1ӟN4@O%YsᏎ0|Dlm5;-^$^y_mHђ$F f )F'j=1xzN%k6܃ ` mnV?wKFs~!xS1꺷&, ڢ\_JyWT_0rV/rW~& ]mZdloIth\:yIyxWQB,U)h Pns%c3 _[ٮVe {ǒ4$bӸ8Q#[t9WI'~ Rn[A&AOK[iQ26u7ەY ʱ}^oM_MeozdK0P.$>`xv> M|1gOk%pip2A#DiFy$b`#,k;_%|7k6<}X y'U;a}>1& i_]KEfk֚5(Ov-%A7ߞ4کpX>–>Z%wvz xgQ4r{vUYpK|3p ѵgtI:c$tC{ULchř~2w:4 &q d XIFMJ,Ȁ+H0XOTf/gះǍ xZVWIp<HH=$M| gkVhǤ¦_hGF*0 Iԓ{B+oN5:u:omhu1@0FPqN~|.RG6p.o?m8iDqD$;p@$^g{1{88k? Okwyjveo{p˕ek0; +į ?I\4G$%۹o .\uR>H2t=jHƧj-5/:E.G $[#rk?JX< FtzpM$QX#d%褧%}GK=P/%8LH$ ,a>`̙WZ,uFgY[ L&tFα:~p9('\rRjΡ'<#% j-dBDfEbX6A* +N>9cxElAcCo(s  mgq'nQIOv>Uǁ?vz.iQ˖wXwb| 2H4q8E jsyۖ q󘲝lwvW_E}Ò=+O jW"e yc\ V2/^nWpK)|/^EWl` \>U-'\M/újLͨ]Gef22\I9I&[/&ÿG-ݭhV2ٍ>@ߗMT.X8|:)㽽׉&no"g>i?y'y۟|k M*I oid"*QGpcu_ kzcWBӎI\i|0-@TB tZ- [hoFek{"QJPB#=9#{@4M#ƣm8$\auqWN'[m"m3n6F/F֗AiF=tnlcXU˭DA`h<[.'{#IbWdMtHI`FkkZo%kT- b<]C>,"c,&z(֗ ug:\[2JV~YJ?tMɁY<:oQ6225M'p)QYQyΰD.Ѥܤvj5]WN4 SUOlgj傌܁ӳthQEAuumeOyyq&i$jK3M!EQYhp\jwQC56; 4,Q'T{ [ %a)7(>]Њvv\ER{(/m-%ȴIT3˵@OQh Ǡ4ER;Kl.][~VNOB(KSԬtjpzm7sv)gcp'zǞ >n$K#H1UPHP1f®FHȪP -κ(Q\'~&šgOc#ʢi` K$2rhĺοCiq /q.v*C {_nO2lQYNjZEW/$ihhs*z{VtZ?8o"VgtqJ,l} ,QH((cOQWLzE{=xŸ*?좯ޗ?O??C袊(((((((>)gT0|.':vt:K)LT!VB 9Qn|S:EQr?<!t[ jVӧɽy\_9>xtR5Նqq&yurs$ZzČdX%b |ΆĞ8F*R8!Pn򔫞\M}? ѽb ~oY܅/-loi-n %d- 2□3O?4-DY[ 5^jv<16RjH>#]#v2|$޿W?-:O-zZ0.eRoQNie+462M~\͉Qx%FFQPb#ʻZ+xF&;.{{+]^ -9(ۑ F@dQ¿xCJJ뚖=ΣgY}6OY !QpjѮEU\>E<;_7+_1^ -ӆYD]>4.i6-4h=y^ɧv({[O{z`j*xWmħI>dzG?, NWFl^ԷPA %81-_/Sh_Ou_ICg\}ex]t`QpTU] 75j}(- 5oOõݪsCRy_4_7MG#Ƴ%_:^]Y$& FS>dg-a$GE~˒drvxZ:Z=:Jך+}:utPl<`IVVđeJ 3oSCMQdIծeK |VrWhM _wZ\!2"v7f 00Uۘ Zl)/%ch}$rrVD}bj|r߱ޛ 濥6[y&m3yϕ(Mlȷk߆~v? I<1~KmB)tlf2)klz ݚ6*m{՛ᧃt]SLͽjjeEŜݫH&E}*78xErhjV,mnOu渞(Im blIog]^]xcL}6%{۸Qw .72vBcfC" }iZbJmhfK᫰%f+V#|Oql.qs +hLcA&YbmMfymW7<iQ6}mR_JWF͵,G .!3 ~H_ht=wPōiw ,חVZ@&vo y߅=zO5iGg-ndCM]d7|ao(`a\aIV/OY\.Pj@k0 c?CUA 1 ߊuo< h.[M> FYb2=,ۭ4R*Rfpz|-7KӼEijwvGrIl̢U^<,\ۣxߴj5.7hX;䛭To@n rN[[i=GwVZ[Deeg >IVVgǎo^jjZSY_ʂ-D̂XI)Ē(+3l?h~ֳ^XtĹlwqdE;WӾ/xV֭hu3@еT(eh| iZ˽6$ f$4{h!9Rߏlj!%LJ5]"}.u65đCVQ$- r(le6sK x V/ݢzemͻ6-$+$\~5@⋿iZͥxU;-BK];+m26=گOoÖ&֬t>}Ȑy͔xff 0$Uą8/}?JWxAXL]NKcfUͥ, y[i D 0*Ak7MfOHԎGࠞaxn<4;cwo$~C 42.'Dcg μM7_?5N.+) ^'͙0QDeֶw1_D֛iNo4H\{ƎTh%Gb lsZ+Cxjmš5t h6J.gXb,p bdUWhǘkmaKط}'kmmk Ej)֯Eѯ[LNk_)6xҙ 1?g JִĞ>Ǭ m/.4 ڠ_$9MyVf9JџtVˤ1#4`$OUWw/_YImW#nf O4do4ęU|1Q)OM(I3o+_i~5U;['P$QQY,g+◊.W- C|MX-s;M%ƞe'-0F7W'|;iimkg w`$)waQ.2,[7ǂ]B[KyW|4QXI$%y X(Cct>:FbZZ\G/tF<{̲aQ\J4ss+>߇G-V&u ]uw]4`}u8Vw5s6|hIk> X}7JNWOk;j]3tXʰs*tZ~-c /VJnum6RX">TXcVA$ iKT~-ևx׌|MJnY!C=դJ%y+WtR̮|74ٓ_Ζ4 j7$]wts[J(O7|U(BﵯAeivzab0mue.J HBQXѿg? x_ê\O`ZJ&"x$2yL5_)ms 5C{ZOtwpfDqd$Oq(مP[|IxRqi\H/4x.ﮁ8KicBBCᘯeߊ*v^Yy;;>| Fۗ*jhVQQErxŸ*?좯z?T~?E_1/~"EaEPEPEPEPEPEPEP|S:EQrSPִm&-WV4nZDӹ @n9eZYg_(9VWſďYh^]^N\-nP1KyCC]j1"ً\+"Lu+5D+-­ű7Dјp$J2Hۯjx4۫Z[Kkn1('WxeſE{[-{"$MNWMbYxC ;M_SXl<[&eoyzt&uo-l-9C3}ԴqXL7򖛧AO5O=Oe5i,M43IߕpofWtB?6*d_ĚjnMu1$݉ .yc~?yӾ4 (\\;\n,=9—ұR ^ ttZZti$h H#WOY_ 7XidӽF6XZGD$%c I&`VAY<8ut\dǻ/>}Me&jǼc~_'{rϦx_U4زIm^ǐYca]$P[AT]po={Exd;ocx8Y08*c@=jό=e:YkSGsmċyR2NZLhxn ]՛7}OռCm[k-_Ul'12%@,]'%`ok+MI/+o( 9v=>-?\ѵK{+*  NG%z֟ihwXXkM[%[[ݣȰ In0joWu"f[mfK$Fe5M>6_<%T}Ť\=Gt؉x[j7|bt$?QGOP\g[B!eQrYm<*_fNҿ.ϲ&ק>((Xƒ|UE7J_%R򞫨Xk\Co?<6sOwkmorȱpϽql:buI5; =@O1sHv3gNo.7l_@U}YE[Vy!evPPK}CzdLƣkk\. DZL"FF[N;uqAmq4lq^x73++#[5>Y,쬯᷸{2ƻRKc +~w⎍$5; ӤIoἽKW>y˅AVdY1ψy뗞:ecow6.L:dz" 677 fi.Z2cmV\% =.^'IUP2Fxf u5J^ԴўDYc &Eܤ׌9uon ^xVTkwQ#_ysYCGI#s۟q/i$xYŹN-iH6` JSKo+iqvčN-VP~Te J}|/}y ,-v&Np'Kk7Zx9mEtk(eKDc5~xYӠRw{ )b!o ɡU7lt(Qm/hOY/h Sk-y7oՌ7bF¶Tw>&ѦM>-NI.&[/&#<!X@Ā7MOoڅ>%a}iO6w|Y4BGe C>c)~PSq-!Mƭ ķrZJP8X7*EɈ]qe7wliOŚ6jVuՌ=k-S1I]F1LURQĞN[{PVSc9 pk~_ē{v%Ȥ&i>_rg8m_\t+[MBէd%x#u|qvJ>|Tp\-޺!I]cJmZ(LY3xR\w/8=EpÕg:F3C{4YYKIVj=X^^?f]&?~,$_9 @|5p[pxSK>_^xPf~i6pKs8ܹ`GV`\36n4He:l7pxE6SwGw8 nć'Jٵ4kbN4Bfyb|WV^GU#|֟^oK4sjVZo~-KZxGִȵ(^ ukk e%Ie|[DѶ)N씘ihSa03 ni Z%} 2eHd iM6=D dQHڼ99)g^^1OK?eG5߈~׌uW7PO]΁fգ[Ci1c%A݆0ItYNW#-PVK,VBg)#Ip&O+&D$!W /VVO݃ݾ^VNE'ܢce-mf! ꥚';V%O qf/kڤZƩii1ȍq,7 o cHPɻ$i+(+D{ֺph崱3nD=j-l<,Хy U31;מE=Φ_7=ģDE޺wQi֗ ,w1 #E$3q k6xë&*C)Ԣ͜vJ7~`MҚ_Sh^=F^[M:ńHf]N6ml8?1! oJ|9ڱVտ !eݳ;^x`]Ύ|S7.7 9n5{}>(ncwu>GEix^(Ӵu{7[,s#C1%|4)x`^v=ξod|GiQ:",3ROAza#v:ӛYҗPl6<O;ns{5Hj麴4{"Mk4%@'NIu;+"3G~I*;C[9(F4 R}*O+ vP\,ordjN]M' .FxIt uVO[xu(A-}C +UQjɼWEu4cYIo?yB pzdrKsx[O[Dk[7G|p" RN1_ņk$@!b*=V̻-/<3"С|NK J[isɪxq kHj>Q$v{]w:j+-WdhLko ~cv9GLmXl洹#,vLZPvE'7.e訬IM} O.dkQXtޛaYۣ-Y]OZfj7A'jvwtZ9e.(aEPEPEPEP^1J(="cOQWLzEoKꈟQE`XQEQEQEQEQEQEQEοQgs\?>g' x ˥Jf':s O9uسϟcSWg-<+-uKIYSisfs ېvF9[D-NeY^0ot*vΑ}ax-7#MڛKw!ز1eug#aj G9o`X~oƭGnY61lo7W '/oh?2Vޏw< h𵞡i 5;P2\i7R˩Cak[ ߙ7J_//?jm;4>)Ҭ-o.l<<.\ƶ^z}%8ߐo7W '/oh?,UW>wU_(iyg]x|H–ZEҕn-ṻKǍ}1ı3.Ǒ)Z:7z~ n,m[M%MyIზԿ[D-·G Z+efW$/Oɭ<7K^ыAq[C̻cACZdb[]mob}&w-]`FO8_"_G+pE~-+G_oS4/t]oFO[+wWME, Nn?q! lR5Ҽ!{{JEF[tm: o"5"F?[D-V}+ O? ;A|qax$+dVח7v]G4Q]“4Wl?"n-#o77w!v5RQi$qMf/мpB ·G Z+o7WOVqqUgq1|MSQoċMF{m"[X~Ekk+y5BV&C1Ag mcKnn.J!ܺ&Hi[dR1l`;u"W6k!aqbo-ٮ +pEV?~#A}'Vm_ S_g6bJdzr1Xsqet^=- ̑ ncxѼL̑|Ty{+SR1ld&}u bn *8ܤe/V?~#A}"FTn}0?|W>3o5pEq%M 6uX9HPuiK h\O8/xu]j)t94}B,J yVO2Q*}lV@Jvg7O8_"_G+pEԓOPat C_ִN}2ŵE[iw|Ci/s;I ng9c8}*)M干#wKOi '/oh?O8_"_O/egKPT%xpkj$In3vr39j 5>𖯬hײx~sȶɥ^ip\*·G Z+o7WufE8} /wu/<]zƥ{([i5<]BݬEUKIKzJ]<-kzų7$Ȍ@XF0=7+pEV?~#A}WI)>^S/k'Xk-GMD^]4DiP1hp+ë[ԬAkw<'H[&*Dx1n]rw7A '/oh?O8_"_CNE Q\>&|(0DKY[jh%ȸܑHKҺ9n1onmu;B]OP<ф,77*bScnbe0+o7W '/oh?YE$-< Ӌz_1,|j]K(Is5!w]e5F`2% {A<a>\i |Yg˵o+FdIѵҬa9>$2O8_"_G+pEVJZne_3Z?13j^Fc1K^ ߈3$9$mX 3Gk6WQ79dDh<uh·G Z+o7WuJmnW|/›|D {M{[`G0+5k7ԪQSs0O>&[O%+YuFSEts*4%r7+pEV?~#A} ӿWmnW|j & ΅麷`fdY:(p1 3R0]xM.YP#eA7mu#SpC $+pEV?~#A}%VK^/8[b2ʹO og,&Qi}$V,N$6#,fI ~4h )t}%Zvd$rg7)b .^ '/oh?O8_"_Uk-|t߃Ig43jzxx;k[Pgc"NU 8&'ԼA ׉4ش; t۬G4lMn6ؼ,DCwS '/oh?O8_"_SNnZ/|Y_I}? ibXI*%Tb=ţm:6UkR]qe%j);x#T1twե '/oh?O8_"_S9="W77+pq͌owy cs֭-S<'Vpi8WS(,'4=6(/+ֺl1ɩݝRHig…Co7W '/oh?V"G_y~̚SY[iZz\w4[ta$anQ !,K?2=2ާ|e SPz|1<tXF\FC8fNsQ?#O|-k{ yÒH#[1608cP>OwƞM__ u =זdl;PT_n_ٮ⇊>x*tWZxb}CDVu*'$#z'_ :lG;61-D 8te@s%Ü4;f%cW_~"φV۴sQD2Iеtk߳O ?(Fn {m2[?ṿvxr5_~ x TΫƥvڏw9h^0nP{MnA}1"tFCb .ݕW~1s?'<;_ ~5 4CsoCZ**"9/tW1Z_~o"_|i,uCNd[2i*.8zӔߑX}f?W:7WcZmJdh[ sdF2IŠ?֯WO{ TtQEhnQEQEQEQEQE<7oOMn,U^#.ฝowNHV +t l澰";קEױI7l7@ 7pAvȠ.x\7/QZ[G俊虣jp}Ax־])4[E/ḊM'ͳ)ch C >~ᅯ>xoAp5G8*cf x ?io g ARVK do"d7$0M#;/3u]ZG<'C9Εsix cYb}GdmiRދ}n k 4%zOnv2)+'cOⷆ|o_/>u3Rm,~W $D3 ct/ ktz-C$W7v6]ZI =0#|!rsG'oߴ_+hwŶz[a5D$4L!@x_g^ҵMK]_@T4XՑI#X 4J̻J8>Lj?g~!~[9.$M ! oCR6\MQEQEQEQEQEQEQEQEQEQEQEQEQE"eL}_W?k}|2ņ|VmtUI_IaFԗIJ%?ij5 y!j'`5c|COÏ8 8x|3_6[ep6r9㺊%T|寄4 ah]<1pu`aZPx-IjSɋ??kٿ/ſ|/'x+<1hŶY$^#kGY_JK<<6XIJiHyYw\SOz~/ q5_ ɤf u-jEص=.0[̝T9 sڽo-|^I ,z'߼)5Ws'kY*qk?᷿h#$Q%?֯WO{~h`Gc$7 >$6|6yӪjsu.o{4F6 >*(((((OCN9 9O~IUƣe:l 2+)RG \<5xEuՏ%s5nv'(((((((((((((((((((((((+/(_ڷ"о|:1mu^w;[CG7 Gˏ+(t0~xp?:?tυ~_ HQ@5s C!q]=ImoǡTׅ7yşcߒOEI#t/5 _kA.~x|Q&~&-4Ѵ".,6h!J)5?2O>ϭ][+í_"88}NMJP_kA1>?fXco`I sa#{81_JxA>.x_ ?iW:Xb6?a#8W×jk?Or]C__ ~_U98<Ʒ&][/'&KRn/gPpIQ5UQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE6866666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p(8HX`~8XV~_HmH nH sH tH @`@ NormalCJ_HaJmH sH tH DA D Default Paragraph FontRiR  Table Normal4 l4a (k (No List PK!pO[Content_Types].xmlj0Eжr(΢]yl#!MB;.n̨̽\A1&ҫ QWKvUbOX#&1`RT9<l#$>r `С-;c=1g~'}xPiB$IO1Êk9IcLHY<;*v7'aE\h>=^,*8q;^*4?Wq{nԉogAߤ>8f2*<")QHxK |]Zz)ӁMSm@\&>!7;wP3[EBU`1OC5VD Xa?p S4[NS28;Y[꫙,T1|n;+/ʕj\\,E:! t4.T̡ e1 }; [z^pl@ok0e g@GGHPXNT,مde|*YdT\Y䀰+(T7$ow2缂#G֛ʥ?q NK-/M,WgxFV/FQⷶO&ecx\QLW@H!+{[|{!KAi `cm2iU|Y+ ި [[vxrNE3pmR =Y04,!&0+WC܃@oOS2'Sٮ05$ɤ]pm3Ft GɄ-!y"ӉV . `עv,O.%вKasSƭvMz`3{9+e@eՔLy7W_XtlPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-!pO[Content_Types].xmlPK-!֧6 -_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!!Z!theme/theme/theme1.xmlPK-! ѐ'( theme/theme/_rels/themeManager.xml.relsPK]#  0 |1=`8@0( -staff:D B S  ?vz  -856789:CD :::::*D1.yʱ ^`OJQJo( 8^8`OJQJo(^`OJQJ^Jo(o  p^ `OJQJo(  @ ^ `OJQJo( x^x`OJQJo(H^H`OJQJ^Jo(o ^`OJQJo( ^`OJQJo(^`5OJPJQJ^Jo(^`OJQJ^Jo(hHopp^p`OJQJo(hH@ @ ^@ `OJQJo(hH^`OJQJ^Jo(hHo^`OJQJo(hH^`OJQJo(hH^`OJQJ^Jo(hHoPP^P`OJQJo(hH1.yԧ         Z _@ЊX@UnknownG*Ax Times New Roman5Symbol3 *Cx Arial;Wingdings? *Cx Courier NewACambria Math"1h΂fF7r@ '@ '24S3QHP)? 2 ,1-16-08 Lymphoma PathologyMichael R. MathisEnabling Technologies Staff   Oh+'0 4@ d p |'1-16-08 Lymphoma PathologyMichael R. Mathis Normal.dotmEnabling Technologies Staff55Microsoft Macintosh Word@,@TZX@VҮ@ ՜.+,D՜.+,l( hp  '(University of Michigan Medical School'  1-16-08 Lymphoma Pathology Title 8@ _PID_HLINKS'ApXDisclaimer-No_Citation_Key  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry F<ҮData 4Z1Tableg!WordDocument40SummaryInformation(DocumentSummaryInformation8CompObj` F Microsoft Word 97-2004 DocumentNB6WWord.Document.8