ࡱ>  xyz{|}~'` 0bjbj sXXXXYYY$YؼؼؼP(YuT Xfj4 xzzzzzz$ɨh19Y+n"++XXpץJ525252+X8Xx52+x5252~XrY68 nqؼ5,X|!TuL,88\YL$6&52(DZ)AL$L$L$1pL$L$L$u++++YYdpCyYYpCYYYXXXXXX Frequently Asked Questions Introduction to the tool This document details some frequently-asked and anticipated questions on hand hygiene in health care. Answers are taken from the available evidence, as outlined within the WHO Guidelines on Hand Hygiene in Health Care (2009), expert opinion and learning from experiences of colleagues in the field. The questions and answers are listed under key headings:  TOC \o "1-2" \h \z \u  HYPERLINK \l "_Toc227653959" 1. Clean Care is Safer Care and SAVE LIVES: Clean Your Hands  PAGEREF _Toc227653959 \h 2  HYPERLINK \l "_Toc227653960" 2. Evidence for Hand Hygiene Guidelines  PAGEREF _Toc227653960 \h 6  HYPERLINK \l "_Toc227653961" 3. Implementing the Hand Hygiene Guidelines  PAGEREF _Toc227653961 \h 11  HYPERLINK \l "_Toc227653962" 4. Country Pledges  PAGEREF _Toc227653962 \h 24  HYPERLINK \l "_Toc227653963" 5. My 5 Moments for Hand Hygiene  PAGEREF _Toc227653963 \h 27  HYPERLINK \l "_Toc227653964" 6. System Change Changing Hand Hygiene Behaviour at the Point of Care  PAGEREF _Toc227653964 \h 34  HYPERLINK \l "_Toc227653965" 7. Alcohol-based Handrub: Formulation & Production  PAGEREF _Toc227653965 \h 39  HYPERLINK \l "_Toc227653966" 8. Alcohol-based Handrub: Risks / Hazards  PAGEREF _Toc227653966 \h 42  HYPERLINK \l "_Toc227653967" 9. Patient Involvement and Empowerment  PAGEREF _Toc227653967 \h 47  Clean Care is Safer Care and SAVE LIVES: Clean Your Hands QUESTIONANSWERWhat is WHO Patient Safety? In October 2004, WHO launched the World Alliance for Patient Safety in response to a World Health Assembly Resolution (2002) urging WHO and Member States to pay the closest possible attention to the problem of patient safety. WHO Patient Safety raises awareness and political commitment to improve the safety of care and facilitate the development of patient safety policy and practice in all WHO Member States. Each year, the team delivers a number of programmes covering systemic and technical aspects to improve patient safety around the world.What are WHO Patient Safety Global Challenges? A core element for WHO Patient Safety is the formulation of a Global Patient Safety Challenge on a topic that covers a major and significant aspect of risk to patients receiving health care and which is relevant to every WHO Member State that will be identified for global action. As of April 2010, two Global Patient Safety Challenges have been formally launched: The First Global Patient Safety Challenge Clean Care is Safer Care was launched in October 2005 The Second Global Patient Safety Challenge Safe Surgery Saves Lives was launched in June 2008What does the First Global Patient Safety Challenge Clean Care is Safer Care involve?The First Global Patient Safety Challenge Clean Care is Safer Care was launched in October 2005 to tackle the problem of health care-associated infection (HCAI) worldwide, with hand hygiene promotion as the cornerstone. It has five components: Clean Practices surgical and emergency procedure safety Clean Products blood transfusion safety Clean Environment safe water, sanitation and waste management Clean Equipment injection safety Clean Hands QUESTIONANSWERThe Clean Hands component was formally launched as the first focus of Clean Care is Safer Care in 2005 and is being strengthened through the SAVE LIVES: Clean Your Hands initiative. Activities to develop the SAVE LIVES: Clean Your Hands initiative started in 2008 and built on the excellent work already achieved as part of Clean Care is Safer Care. It is a key component of sustainability and will take global hand hygiene improvement to its next natural phase. As part of the SAVE LIVES: Clean Your Hands initiative, health-care facilities across the world are encouraged to refer to WHO Guidelines on Hand Hygiene in Health Care (2009), which are available in their final, revised and updated version as of May 2009, to improve hand hygiene and thus reduce HCAI. A series of tools and a comprehensive Guide to Implementation based upon the guidance outlined in the WHO Guidelines on Hand Hygiene in Health Care (2009) have been designed and field tested to support health-care facilities across the world to prepare and implement action plans to improve hand hygiene, irrespective of their starting point. They can be accessed via the WHO Patient Safety website at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/.Why is WHO Patient Safety refocusing on the First Global Patient Safety Challenge (Clean Care is Safer Care) when the second GPSC (Safe Surgery Saves Lives) was launched in summer 2008?The First Global Patient Safety Challenge, Clean Care is Safer Care, is an ongoing initiative. Launched in 2005, this Challenge was and is intended to be a long-term key focus for WHO Patient Safety (alongside the other Challenges), thus acknowledging that health care-associated infection as a major patient safety problem requires ongoing input in order to drive and sustain local improvements. Since 2005, 123 member states (April 2010) have pledged their support to address HCAI alongside the Global Patient Safety Challenge programme. Subsequent to these pledges that established a global commitment to improving hand hygiene in health care, work has been continuing to refine the tools and materials needed to support each member state in achieving their specific goals for their hand hygiene initiatives. The programme has thus entered a new phase in which a finalised and practical series of tools is available to assist in the translation of political commitment into tangible delivery of action plans at the point of care. QUESTIONANSWERWill the First Global Patient Safety Challenge end?This Global Patient Safety Challenge started its life in 2005 to focus on the universal problem of health care-associated infection. Given the importance of the topic of health care-associated infection and the need for strengthening actions to prevent them, activities have been further expanded in 2009. The work of the First Challenge will continue as a long-term programme to ensure that the initiatives related to hand hygiene do not become frozen in time. What is the SAVE LIVES: Clean Your Hands initiative?SAVE LIVES: Clean Your Hands is one of the main streams of work of Clean Care is Safer Care to continue with a natural next phase. It further encourages health-care facilities across the world to improve hand hygiene in an effort to reduce health care-associated infection (HCAI) and thus the associated morbidity and mortality. To clarify, the SAVE LIVES: Clean Your Hands initiative builds on the work and significant progress of the WHO Patient Safetys First Global Patient Safety Challenge, Clean Care is Safer Care. Focusing on hand hygiene in patient safety, the SAVE LIVES: Clean Your Hands initiative reinforces the "My 5 Moments for Hand Hygiene" approach as key to protect the patient, the health-care worker and the health-care environment against harmful germs and thus, reduce HCAI. As part of this initiative, WHO Patient Safety has provided a series of tools and a comprehensive Guide to Implementation based upon the guidance outlined in the WHO Guidelines on Hand Hygiene in Health Care (2009). The tools are designed to support health-care facilities across the world to prepare and implement action plans to improve hand hygiene, irrespective of their current levels of hand hygiene, education and awareness of the "My 5 Moments for Hand Hygiene" approach or the resources necessary to implement change. The tools and guidance can be accessed via the WHO Patient Safety website at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/.What are the aims of the SAVE LIVES: Clean Your Hands initiative?The aims of the SAVE LIVES: Clean Your Hands initiative are to: Inspire best practice in hand hygiene in all health-care settings Move the "My 5 Moments for Hand Hygiene" approach from theory to practice Improve global compliance with the "My 5 Moments for Hand Hygiene" approach Reduce health care-associated infections through improved hand hygiene worldwideQUESTIONANSWERHow long will the SAVE LIVES: Clean Your Hands initiative continue?WHO Patient Safety has set a target of continuous improvement of global compliance to the "My 5 Moments for Hand Hygiene" approach up to 2020. Thus, this initiative is currently planned to run until at least 2020 and reflects the complexities of changing behaviour in health care.How do I participate in the SAVE LIVES: Clean Your Hands initiative?All health-care facilities across the world are encouraged to participate in the SAVE LIVES: Clean Your Hands initiative by increasing compliance with the "My 5 Moments for Hand Hygiene" approach and thus reducing health care-associated infection and the associated morbidity and mortality. Health-care facilities are encouraged to register their interest through the WHO Patient Safety website at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/ and to access all the resources provided by WHO Patient Safety to support health-care facilities to improve hand hygiene. Please also refer to the SAVE LIVES: Clean Your Hands Frequently-asked Questions available at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/ for further information.  Evidence for Hand Hygiene Guidelines QUESTIONANSWERHow significant is the problem of infections in health care across the world?Health care-associated infections (HCAI) occur worldwide and affect hundreds of millions of patients both in developed and developing countries. Lack of reliable and standardized surveillance data suggests a significant underestimation of the real burden of disease. The risk of acquiring HCAI is universal and pervades every health-care facility and system around the world. Health-care workers are often the conduit for the spread of such infections to other patients in their care. It should also be noted here that many patients may carry microbes without any obvious signs or symptoms of an infection (colonized or sub clinically-infected). This clearly reinforces the need for hand hygiene, irrespective of the type of patient being cared for.How important are clean hands in the overall patient safety agenda?Hand hygiene contributes significantly to keeping patients safe. It is a simple, low-cost action to prevent the spread of all microbes that cause health care-associated infection (HCAI). While hand hygiene is not the only measure to counter HCAI, compliance with it alone can dramatically enhance patient safety, because there is much scientific evidence showing that microbes causing HCAI are most frequently spread between patients on the hands of health-care workers. In addition, health-care facilities which readily embrace strategies for improving hand hygiene also prove more open to a closer scrutiny of their infection control practices in general. Therefore, the knock-on impact of focusing on hand hygiene can lead to an overall improvement in patient safety across an entire organization. Finally, the selection of hand hygiene by WHO Patient Safety as the first pillar of the First Global Patient Safety Challenge signifies its importance in the patient safety agenda. QUESTIONANSWERIs there a difference in the rate of health care-associated infection (HCAI) between developed and developing countries?Although no health-care setting across the globe can claim to be free of HCAI, there is a difference between developed and developing countries in terms of the incidence and type of infections. Details are presented below for clarity: Developed countries: In developed countries, with sophisticated treatments and technologies, HCAI continues to account for complications in 515% of hospitalized patients. For example, HCAI is among the top 10 leading causes of death in the US, accounting for 1.7 million affected patients and approximately 99,000 deaths in 2002. The annual economic impact of HCAI in the USA was approximately US$ 6.5 billion in 2004. Developing countries: Limited data on HCAI from developing countries are available from the literature and most of these studies concern single hospitals and therefore may not be representative of the problem across the whole country. Nevertheless, studies conducted in developing countries report hospital-wide rates higher than in developed countries. For example, in a systematic review of literature, neonatal infections were reported to be 320 times higher among hospital-born babies in developing than in developed countries. The burden of HCAI is even more severe in high-risk populations such as adults housed in intensive care units, with general infection rates, particularly device-associated infection rates, several-fold higher than in developed countries.Why is hand hygiene compliance still low after all the efforts in recent decades?In recent years many parts of the world have seen major improvements in hand hygiene. However, there is still not enough access to clean water, not enough sinks or towels, not enough awareness of the central role played by hand hygiene, and not enough investment in a multifaceted approach to tackle the abysmally low levels of compliance. There are many factors which contribute to low compliance and these are listed within the WHO Guidelines on Hand Hygiene in Health Care (2009), Part I, Chapter 16. Whatever the reasons, even in resource-rich settings, compliance can be as low as 0%, with compliance levels most frequently well below 40%. QUESTIONANSWERWhat types of microbes can spread due to lapses in hand hygiene?The following are examples of the types of microbes that can be spread on the hands of health-care workers: Staphylococcus aureus (including MRSA) Streptococcus pyogenes (Group A Strep) Vancomycin-resistant Enterococcus (VRE) Klebsiella (including ESBL-producing Klebsiella) E. coli (including ESBL-producing E. coli) Enterobacter spp Pseudomonas spp (including multidrug-resistant Pseudomonas spp) Clostridium difficile Candida spp Rotavirus Adenovirus Hepatitis A virus Norovirus Wounds will contain large numbers of microbes. Areas around the perineum can be heavily loaded with microbes, but even the armpit, trunk and hands can be frequently covered in huge numbers. Microbes such as Staphylococcus aureus and Klebsiella can be present on intact skin in numbers ranging from 100 to 1,000,000 per square cm. It is easy to understand that the hands of health-care workers can become contaminated even after seemingly clean procedures such as: Taking a pulse Taking blood pressure readings Taking a temperature Touching a patients hand, shoulder or groin Furthermore, several studies have presented dramatic evidence that microbes have an impressive ability to survive on the hands, sometimes for hours, if hands are not cleaned. All of the studies clearly demonstrate that contaminated hands can be vehicles for the spread of microbes. QUESTIONANSWERWhy has it been necessary for the WHO to issue Hand Hygiene Guidelines?Many countries already have some form of guide on hand hygiene, however, the WHO Guidelines on Hand Hygiene in Health Care (2009) have been subject to a unique process of development and testing. In addition they have been conceived with a global perspective, aiming at meeting needs and approaches from countries with different resources. This makes them useful to many national safety and infection control bodies for the added value they bring to previous efforts to improve hand hygiene. In order to implement good hand hygiene practice based on the guidance detailed in the WHO Guidelines on Hand Hygiene in Health Care (2009), health-care facilities are encouraged to prepare an action plan for necessary improvements in hand hygiene. To assist health-care facilities to prepare and execute an action plan, WHO Patient Safety has provided a series of tools and a comprehensive Guide to Implementation. The tools and guidance can be accessed via the WHO Patient Safety website at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/.How different are the WHO Hand Hygiene Guidelines from the CDC Guidelines?The WHO Guidelines on Hand Hygiene in Health Care (2009) build on the rigour of the 2002 CDC Guidelines, but update them with many additional innovative aspects. The CDC Guidelines focused on Hand Hygiene in health-care settings, particularly directed to developed countries. With this starting point, the WHO Guidelines on Hand Hygiene in Health Care (2009) have attempted to focus on health care in all countries of the world. Extensive work, including around 300 pages and over 1000 references, make these WHO Guidelines on Hand Hygiene in Health Care (2009) a must-have resource for any region, country or facility that is serious about tackling hand hygiene. Finally, a large group of international infection control experts continue to contribute to the development of the WHO Guidelines on Hand Hygiene in Health Care (2009). One unique component of the WHO Guidelines on Hand Hygiene in Health Care (2009) are the associated tools to assist regions, countries and facilities in their implementation. The WHO Guidelines on Hand Hygiene in Health Care (2009) and the tools for implementation underwent rigorous field-testing, and were finalized on the basis of the results and lessons learned from the testing.How frequently will the WHO Guidelines on Hand Hygiene in Health Care (2009) be updated?The WHO Guidelines on Hand Hygiene in Health Care (2009) are intended to be reviewed every 2 to 3 years. QUESTIONANSWERWhy did the WHO Guidelines on Hand Hygiene in Health Care (2009) undergo pilot testing? Where did the pilot testing take place?According to WHO recommendations for guideline preparation, a testing phase of the guidelines was undertaken. The WHO Multimodal Hand Hygiene Improvement Strategy and the Implementation tools were pilot tested to provide local data on the resources required to carry out the recommendations; to generate information on feasibility, validity, reliability, and costeffectiveness of the interventions; and to adapt and refine proposed implementation strategies. Eight pilot sites from seven countries (Bangladesh, Costa Rica, Hong Kong SAR, Italy, Kingdom of Saudi Arabia, Mali and Pakistan) representing all WHO regions were selected for pilot testing and received technical and, in some cases, financial support from the First Global Patient Safety Challenge team. Other health-care settings around the world volunteered to participate autonomously in the testing phase, and these were named Complementary Test Sites. Lessons learned from pilot and complementary sites are reported in the WHO Guidelines on Hand Hygiene in Health Care (2009). Implementing the Hand Hygiene Guidelines QUESTIONANSWERHow does my facility begin to implement the WHO Guidelines on Hand Hygiene in Health Care (2009), particularly as we currently do not have the infrastructure necessary to be compliant with the "My 5 Moments for Hand Hygiene" approach? WHO Patient Safety have produced a Guide to Implementation and a series of tools to support health-care facilities across the world in developing an action plan to establish good hand hygiene practices and reduce health care-associated infection. Acknowledging the vastly different levels of awareness and barriers to implementing good hand hygiene from country to country, the tools are designed to support health-care workers to improve hand hygiene at their facilities, regardless of their starting point. These documents can be accessed via the WHO Patient Safety website at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/.How does a facility get access to the Guide to Implementation and associated tools?The Guide to Implementation and the associated tools are freely accessible via the WHO Patient Safety website at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/.How do I access and reproduce the hand hygiene tools on the SAVE LIVES: Clean Your Hands website if I do not have access to the internet or printing resources at my health-care facility?If you have any difficulties accessing the tools and resources on the WHO Patient Safety website, please contact WHO Patient Safety at  HYPERLINK "mailto:savelives@who.int" savelives@who.int and we will work with our regional patient safety colleagues to facilitate distribution.  QUESTIONANSWERWhat tools and resources are available?In addition to the WHO Guidelines on Hand Hygiene in Health Care (2009) and a summary version of these Guidelines, a series of tools are available on the WHO Patient Safety website ( HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/) to support health-care facilities to prepare effective action plans to improve hand hygiene, regardless of their starting point. The tools are categorized according to the five components of the WHO Multimodal Hand Hygiene Improvement Strategy that all health-care facilities should address in order to improve hand hygiene: System change Access to a safe, continuous water supply as well as to soap and towels; Readily accessible alcohol-based handrub at the point of care Training / Education Evaluation and feedback Reminders in the workplace Institutional safety climate Active participation at both the institutional and individual levels; Awareness of individual and institutional capacity to change and improve (self-efficacy); and Partnership with patients and patient organizations Requirements for support to address the 5 components are likely to vary between health-care facilities. The Guide to Implementation is a key tool that provides comprehensive advice on how to develop an effective hand hygiene improvement action plan and how to use the other tools. This tool will help you to ascertain which other supporting tools will be most relevant to your health-care facility. A Template Action Plan is also provided. QUESTIONANSWERTools to support System change are as follows: Ward Infrastructure Survey to collect data about structures and resources at ward level Alcohol-based Handrub Planning and Costing Tool to help determine the feasibility of implementing alcohol-based handrub at your health-care facility Guide to Local Production: WHO-recommended Handrub Formulations how to produce alcohol-based handrub at your health-care facility Soap/Handrub Consumption Survey to capture data on usage of hand hygiene resources Protocol for Evaluation of Tolerability and Acceptability of Alcohol-based Handrub in Use or Planned to be Introduced: Method 1 to evaluate alcohol-based handrub usage and the skin condition following use Protocol for Evaluation and Comparison of Tolerability and Acceptability of Different Alcohol-based Handrubs: Method 2 to compare the acceptability of different alcohol-based handrubs Tools to support Training / Education are as follows: Slides for the Hand Hygiene Co-ordinator to help your hand hygiene representative to advocate hand hygiene to health-care workers and managers Slides for Education Sessions for Trainers, Observers and Health-care Workers to train health-care workers on health care-associated infection and hand hygiene Hand Hygiene Training Films and Accompanying Slides to train health-care workers on health care-associated infection and hand hygiene Hand Hygiene Technical Reference Manual guidance for health-care workers trained to apply, monitor and train hand hygiene Observation Form to monitor hand hygiene Hand Hygiene Why, How and When Brochure a summary of appropriate hand hygiene Glove Use Information Leaflet on the appropriate use of gloves with respect to hand hygiene Your 5 Moments for Hand Hygiene Poster to display at your health-care facility Frequently-asked Questions answers to your questions on hand hygiene in health care Key Scientific Publications view a bibliography of selected publications on hand hygiene Sustaining Improvement Additional Activities for Consideration by Health-care Facilities advice on possible supplementary activities to maintain the momentum and standards of hand hygiene QUESTIONANSWERTools to support Evaluation and feedback are as follows: Hand Hygiene Technical Reference Manual guidance for health-care workers trained to monitor hand hygiene at the facility Observation Form and Compliance Calculation Form to monitor hand hygiene Ward Infrastructure Survey to collect data about structures and resources at ward level Soap / Handrub Consumption Survey to capture data on usage of hand hygiene resources Perception Survey for Health-care Workers to assess perceptions of health care-associated infection and hand hygiene Perception Survey for Senior Managers to assess perceptions of health care-associated infection and hand hygiene Hand Hygiene Knowledge Questionnaire for Health-Care Workers to assess knowledge on the essential aspects of hand hygiene Protocol for Evaluation of Tolerability and Acceptability of Alcohol-based Handrub in Use or Planned to be Introduced: Method 1 to evaluate alcohol-based handrub usage and the skin condition following use Protocol for Evaluation and Comparison of Tolerability and Acceptability of Different Alcohol-based Handrubs: Method 2 to compare the acceptability of different alcohol-based handrubs Data Entry Analysis Tool and associated Instructions includes a pre-prepared framework for data analysis Data Summary Report Framework a template for analysis and reporting of hand hygiene data Tools to support Reminders in the workplace are as follows: Hand Hygiene Posters posters on Your 5 Moments for Hand Hygiene, How to Handrub and How to Handwash to display at your health-care facility Hand Hygiene Leaflets leaflets on the Why, How and When of hand hygiene SAVE LIVES: Clean Your Hands Screensaver for your computer screens QUESTIONANSWERTools to support Institutional safety climate are as follows: Template Letter to Advocate Hand Hygiene to Managers to assist a person interested in introducing / reinvigorating hand hygiene initiatives in acquiring support from key decision makers Template Letter to Communicate Hand Hygiene Initiatives to Managers to help a person interested in introducing / reinvigorating hand hygiene initiatives in communicating important messages to key health-care workers Guidance on Engaging Patients and Patient Organizations in Hand Hygiene Initiatives advice for engaging patients and patient organizations Sustaining Improvement Additional Activities for Consideration by Health-care Facilities advice on possible supplementary activities to maintain the momentum and standards of hand hygiene SAVE LIVES: Clean Your Hands Promotional Film a short film with powerful imagery to promote hand hygieneShould I be using or implementing all of the resources available?The tools and materials available via the WHO Patient Safety website ( HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/) have been created to assist health-care facilities across the world to improve hand hygiene and thus reduce health care-associated infection regardless of their current levels of hand hygiene. Therefore, a large number of different tools are available, not all of which will be needed by every health-care facility. You are encouraged to read the Guide to Implementation to help you ascertain which other supporting tools will be most relevant to your health-care facility. You may use any of the tools that you think will be of use to help prepare an action plan and improve hand hygiene at your health-care facility. My facility is already very advanced in its hand hygiene improvement strategy and has an ongoing action plan and review cycle. Do we need any additional tools or support?For health-care facilities that have already implemented comprehensive hand hygiene initiatives, some tools have been provided that may help the facility to maintain the momentum of their excellent work, to either maintain high standards or increase them even further. These tools can be accessed via the WHO Patient Safety website at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/. QUESTIONANSWERDo the WHO Guidelines on Hand Hygiene in Health Care (2009) address behavioural aspects of health-care workers' compliance with hand hygiene?Hand hygiene behaviour varies significantly among health-care workers, thus suggesting that individual features could play a role in determining behaviour. One of the chapters of the WHO Guidelines on Hand Hygiene in Health Care (2009) has been allocated to this topic and covers issues such as social sciences and health behaviour, behavioural aspects of hand hygiene, factors influencing behaviour and potential target areas for improved compliance.Are there many other hand hygiene guidelines across the world?Guidelines either entirely dedicated to hand hygiene or with a substantial section on it are available at national and sub-national guidelines in some countries. Nevertheless, objectives, target, definitions and terminology, methods for selecting and evaluating evidence and implementation strategies largely differ across the documents. To overcome these discrepancies and inconsistencies, there is general consensus that the WHO Guidelines on Hand Hygiene in Health Care (2009) is the most comprehensive evidence-based document produced on the topic, as it incorporates the key recommendations from previously published national or international guidelines. In addition, the added-value component of the implementation strategy and supporting tools makes the WHO Guidelines on Hand Hygiene in Health Care (2009) potentially more relevant and applicable. Local adaptation is however of utmost importance in order to ensure wide and actual adoption. A comparison of national and sub-national guidelines for hand hygiene has been conducted and reported in Part VI of WHO Guidelines on Hand Hygiene in Health Care (2009).Why should countries use the WHO Guidelines on Hand Hygiene in Health Care (2009), rather than continue to use their own?Countries are advised to review their existing guidelines and where necessary to consider the use of WHO strategies and guidelines. Where existing guidelines are in alignment with WHO recommendations there is no need to make unnecessary changes. In many cases, however, WHO is aware that stand-alone hand hygiene guidelines simply do not exist. The WHO Guidelines on Hand Hygiene in Health Care (2009) provide a blueprint for the development of robust stand-alone guidelines, which carry weight within a country or a facility. QUESTIONANSWERWhat are the other WHO plans to further help the global community to prevent and control the spread of health care-associated infection (HCAI)?Hand hygiene promotion through the actions of the First Global Patient Safety Challenge has been the entrance door for raising awareness and strengthening infection control in many countries and health-care settings. Building on this important achievement in the near future, the work of the Challenge will expand to other infection control interventions, in collaboration with other WHO departments. WHOs programmes on blood safety, immunization safety, safe clinical procedures, and safe water and sanitation, are all aimed at preventing and controlling the spread of HCAI. WHO also provides detailed advice on infection prevention and control in specific fields such as SARS, or preparedness against a potential influenza pandemic. Hand hygiene is an essential part of standard precautions, and together with droplet precautions (which essentially means wearing a mask when appropriate), is the primary action to limit cross-transmission of influenza, including influenza A (H1N1), which can be readily inactivated by alcohol-based handrubs. Hand hygiene education and promotion campaigns in the community are ongoing in certain parts of the world (some are briefly reviewed in the WHO Guidelines on Hand Hygiene in Health Care (2009) document itself), and strategies for education, promotion and behaviour changes, while sharing common elements, do differ in the community compared to health-care settings. The focus of the WHO Guidelines on Hand Hygiene in Health Care (2009) is on hand hygiene within health-care settings; however, it is clear that a joined-up approach will result in a better chance of success. The Second Global Patient Safety Challenge, Safe Surgery Saves Lives, is concerned with improving the safety of surgical care around the world. Part of this work naturally aims to ensure that methods to reduce surgical site infection are applied across all health-care facilities in order to minimize unnecessary loss of life and serious complications to patients undergoing surgery. QUESTIONANSWERWhat is the Multimodal Hand Hygiene Improvement Strategy?The WHO Guidelines on Hand Hygiene in Health Care (2009) list a number of components that should be addressed in order to establish appropriate hand hygiene in health care. These components comprise the Multimodal Hand Hygiene Improvement Strategy. The components of the Multimodal Hand Hygiene Improvement Strategy are as follows: 1. System change Access to a safe, continuous water supply as well as to soap and towels; Readily accessible alcohol-based handrub at the point of care 2. Training / Education 3. Evaluation and feedback 4. Reminders in the workplace 5. Institutional safety climate Active participation at both the institutional and individual levels; Awareness of individual and institutional capacity to change and improve (self-efficacy); and Partnership with patients and patient organizations For more information on the Multimodal Hand Hygiene Improvement Strategy, please refer to the WHO Guidelines on Hand Hygiene in Health Care (2009) and the Guide to Implementation available via the WHO Patient Safety website at www.who.int/gpsc/5may/en/.  QUESTIONANSWERWhat are the resources needed for achieving hand hygiene improvement according to the WHO Multimodal Hand Hygiene Improvement Strategy?Improving hand hygiene in health care is a relatively low cost intervention. Resources required will depend on the existing infrastructures and strategies in a country or health-care facility and on the sophistication of the chosen approach. In a situation where hand hygiene improvement has never before been addressed, and based on the minimum criteria for implementation contained within the Guide to Implementation, likely costs are as follows: Human Resource: A responsible person to coordinate activity. This person should have a clinical background at a senior level and this can be incorporated within an existing role incurring no up-front cost; however, a dedicated person is preferable Start-up costs: Alcohol-based handrub: Point-of-care handrub varies in cost and availability If a commercial product is available, after giving the priority to the selection criteria of efficacy (according to international standards) and of demonstrated tolerability and acceptability by health-care workers, the cheapest product should be sourced. The product should be well tolerated and accepted by health-care workers. It may be worthwhile to assess whether the product can be sourced at a discount price. If there is no commercial product available, consider local production using the WHO-recommended formulation. Costs for local production vary greatly as they are influenced by the local costs of raw materials and the quantities produced. The toolkit contains a tool to assist in estimating required quantities and likely costs Sink to bed ratio: facilities should aim for at least one sink to every 10 beds Soap and fresh towels at each sink Training and education: Training is a key component of the strategy. Costs associated with training include capacity to deliver training and geographical area to deliver training Evaluation and feedback: Two periods of observational monitoring are required (baseline and follow-up) and depending on the extent of the implementation, at least one person must be available to undertake the observations. Observers require a minimum of 2 hours of training in observation techniques QUESTIONANSWERReminders in the workplace (posters): As a minimum, the "How To" (technique) posters and the "Your 5 Moments for Hand Hygiene" poster should be displayed in all clinical areas. Costs associated with translation, adaptation, and printing need to be factored in Recurrent costs: The main on-going costs relate to human resource (i.e. a person who has responsibility, not necessarily full-time) for coordinating activity over at least a 5-year period Alcohol-based handrub usage is likely to increase and will form the main ongoing cost Training: refresher training is required on an annual basis Reminders: posters should change and evolve and ideally fit with the local culture and context. The WHO designed posters are useful at start-up, but consideration should be given to local development, using local artists/designers and marketers if available, and reflect local context. Some facilities have used local artists or volunteers with expertise in this area, at no cost and with excellent resultsHow to assess the status of hand hygiene resources and promotion in my health-care facility in relation to the WHO recommendations and strategy?A new tool called the Hand Hygiene Self-Assessment Framework has been made available recently by WHO. It is a validated, systematic and essential tool to help assess hand hygiene promotion and practices in health-care facilities. In particular, the Hand Hygiene Self-Assessment Framework is intended to: assess the level of progress of health-care facilities with regards to infrastructures, resources, actions, commitment and achievements, in order to ensure optimal hand hygiene practices; facilitate development of an action plan for facilities hand hygiene improvement programmes; identify key issues requiring attention and improvement and to document progress over time through the repeated use of the Framework. The Hand Hygiene Self-Assessment Framework is divided into five components and 27 indicators. The five components reflect the five elements of the Multimodal Hand Hygiene Improvement Strategy and the indicators have been selected to represent the key elements of each component. The framework can be used globally, by health-care facilities at any level of progress as far as hand hygiene promotion is concerned. What are WHO regulations regarding the use of WHO emblem?Please visit  HYPERLINK "http://www.who.int/about/licensing/emblem/" www.who.int/about/licensing/emblem/. What are WHO regulations regarding WHO copyrighted material?Please visit  HYPERLINK "http://www.who.int/about/copyright/" www.who.int/about/copyright/.What are WHO regulations regarding reprinting of WHO information materials?Please visit  HYPERLINK "http://www.who.int/about/licensing/reprints/" www.who.int/about/licensing/reprints/.What are WHO regulations regarding translation of WHO information materials?Please visit  HYPERLINK "http://www.who.int/about/licensing/translations/" www.who.int/about/licensing/translations/. Is it possible to prioritize the recommendations of WHO Guidelines on Hand Hygiene in Health Care (2009) to help facilitate a country to embark on this approach?The multimodal nature of the recommendations of the WHO Guidelines on Hand Hygiene in Health Care (2009) makes their prioritization difficult. Also, the overall success may depend upon several elements working simultaneously and synergistically (the sum being greater than the contributory parts). Therefore, for the best chance of success it is recommended to implement the Multimodal Hand Hygiene Improvement Strategy. To implement the Multimodal Hand Hygiene Improvement Strategy, it is recommended that health-care facilities prepare an action plan that considers each of the key elements of the Multimodal Hand Hygiene Improvement Strategy. Not all facilities will be able to initiate actions on all of the components of the Multimodal Hand Hygiene Improvement Strategy immediately, but preparing a multimodal action plan will, at the least, ensure that facilities consider suitable time frames in which they might address the different components. To assist health-care facilities to prepare and execute an action plan, WHO Patient Safety has provided a series of tools and a comprehensive Guide to Implementation. The tools and guidance can be accessed via the WHO Patient Safety website at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/. QUESTIONANSWERCan the WHO Guidelines on Hand Hygiene in Health Care (2009) and implementation strategies be used in health-care settings other than hospitals (ambulatory care, long-term care facilities)?While the primary focus of the WHO Guidelines on Hand Hygiene in Health Care (2009) is on hospitals, the Guidelines and most tools can be applied to any setting where health care is delivered. For example, the "My 5 Moments for Hand Hygiene" concept and approach is independent of the setting and is based on the health care activity. Similarly, the tools showing how to handrub and handwash are also independent of the setting. Nevertheless substantial adaptation may be needed in particular settings (i.e. primary care, ambulances, emergency situations, excess bed-occupation due to overcrowding). For example, the Ward Infrastructure Survey, the Guide to Implementation, and other survey formats and some other tools may require modification. We encourage end-users to adapt the tools by translating and modifying them to suit their needs. Knowledge improvement resulting from implementation and further research is needed in this area and the First Global Patient Safety Challenge is committed to promote it. Can the WHO Guidelines on Hand Hygiene in Health Care (2009) be used outside of health care?The evidence on which the WHO Guidelines on Hand Hygiene in Health Care (2009) are based comes mostly from health-care settings. However, many of their recommendations are relevant also to non-health-care settings, especially with regards to behaviour change requiring a Multimodal Hand Hygiene Improvement Strategy.Should targets be set for hand hygiene compliance? If so, what level of increase would be good?WHO Patient Safety is advocating that by 2020 all health-care facilities will achieve year on year improvements in compliance and infrastructures to support compliance with the "My 5 Moments for Hand Hygiene" approach. However, all local targets should first be realistic and attainable, in view of the long-term efforts required to bring about improvements in hand hygiene behaviour. Aiming for very high levels of compliance in the short-term would obviously be difficult to achieve in facilities where the initial compliance rate may be less than 10%. What should be aimed for locally is the establishment of a baseline, and a steady, sustainable, month-by-month, year-on-year improvement. Based on experience within WHO pilot sites (2006-2008), initial improvement to reach 4050% compliance with hand hygiene is achievable within a few months to a year, following implementation of the strategy. Further increase above this is more difficult to achieve; however once a 50% compliance rate is achieved, an annual 10% increase is a realistic target. QUESTIONANSWERWhat are the commodities required to implement the WHO Guidelines on Hand Hygiene in Health Care?Consumables: Alcohol-based handrubs (either locally produced or a commercial product compliant with WHO recommendations) 100 ml alcohol-compatible plastic bottles for the handrub (pocket carriage by health-care workers) Non-medicated liquid soap. Alternatively, non-medicated bar soap (small bars) with soap racks to facilitate drainage 4. Dispensers for liquid soap 5. Antimicrobial soap for surgical hand scrub Single-use hand towels Creams or lotions for skin care (they should not interfere with the antimicrobial action of handrub) Medical gloves - single use examination gloves for routine patient care Medical gloves - sterile surgical gloves Other items: 1. Sinks 2. Clean running water 3. 500 ml wall-mounted dispensers for alcohol-based handrub 4. Printed material Reminders in the workplace - e.g. posters Educational tools (leaflets, brochures, handouts of hand hygiene training slides, etc) Advocacy documents for senior managers Evaluation tools (e.g. ward infrastructure survey, hand hygiene observation, etc) Country Pledges QUESTIONANSWERMy Minister of Health signed a Pledge statement regarding health-care associate infection (HCAI). What is this Pledge? As of 5 May 2010, Ministries of Health from 123 countries have signed a statement pledging to support to address HCAI. In these Pledges, the ministers acknowledged the following: The serious disease burden and significant economic impact that HCAI places on patients and health systems throughout the world The majority of these infections are treatable and avoidable The momentum that the WHO First Global Patient Safety Challenge (Clean Care is Safer Care) is bringing to reduce HCAI infection at the global level A unique opportunity now exists to reverse the incidence of HCAI in their country By signing the Pledge, the ministers resolved to the following: To work to reduce HCAI through actions such as: Acknowledging the importance of HCAI Developing or enhancing ongoing campaigns at national or sub-national levels to promote and improve hand hygiene among health care providers Making reliable information available on HCAI at community and district levels to foster appropriate actions Sharing experiences and, where appropriate, available surveillance data, with the WHO Patient Safety team Considering the use of WHO strategies and guidelines to tackle HCAI, in particular in the areas of hand hygiene, blood safety, injection and immunization safety, clinical procedures safety and water, sanitation and waste management safety To work with health professionals and associations in this country: To promote the highest standards of practice and behaviour to reduce the risks of HCAI To foster and sustain collaboration with research institutions, training schools, educational centres, universities and health-care settings of other WHO Member States to ensure full utilization of knowledge and experience in the field of HCAI To encourage senior management support and role-modelling from key health-care workers to promote the implementation of interventions to reduce HCAI QUESTIONANSWERWhat do Ministers of Health commit to by signing the statement of commitment (Pledge)?The general template for pledges, which most countries have used, with some additions or amendments, lists a series of actions which the ministry resolve to work towards to reduce health care-associated infection (HCAI). These are listed below: Acknowledge the importance of HCAI Develop or enhance ongoing campaigns at national or sub-national levels to promote and improve hand hygiene among health care providers Make reliable information available on HCAI at community and district levels to foster appropriate actions Share experiences and, where appropriate, available surveillance data, with WHO Patient Safety Consider the use of WHO strategies and guidelines to tackle HCAI, in particular in the areas of hand hygiene, blood safety, injection and immunization safety, clinical procedures safety, and water, sanitation and waste management safety In addition, ministers resolve to work with health professionals and associations in their country: To promote the highest standards of practice and behaviour to reduce the risks of HCAI To foster and sustain collaboration with research institutions, training schools, educational centres, universities and health-care settings of other WHO Member States, to ensure full utilization of knowledge and experience in the field of HCAI To encourage senior management support and role-modelling from key health-care workers to promote the implementation of interventions to reduce HCAI An example of a statement pledging support to address health care-associated infection can be accessed at http://www.who.int/gpsc/resources/example.pledge.statement/en/index.html. How many countries have already pledged by signing a statement?As of 5 May 2010, 123 countries have pledged. In almost all of the countries, a high profile event has taken place to mark the occasion, and the Minister of Health has made a commitment using the pledge template provided by WHO, with some modifications. In total, the countries that have signed the pledge to tackle health care-associated infection represent around three-quarters of the worlds population. QUESTIONANSWERHas my country pledged?The following 123 countries have pledged by signing a statement: African region: Benin, Burkina Faso, Burundi, Cameroon, Central African Republic (CAR), Cape Verde, Chad, Comoros, Congo, Cte d'Ivoire, Democratic Republic of the Congo (DRC), Eritrea, Ethiopia, Equatorial Guinea, Gabon, Gambia, Ghana, Guinea, Kenya, Lesotho, Madagascar, Malawi, Mali, Mauritius, Mozambique, Namibia, Niger, Nigeria, Rwanda, Senegal, South Africa, Tanzania, Togo, Uganda, Zimbabwe (35). Americas region: Argentina, Bolivia, Brazil, Canada, Chile, Colombia, Costa Rica, Cuba, Dominican Republic, El Salvador, Ecuador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, United States of America, Uruguay and 14 Caribbean States (34). Eastern Mediterranean region: Bahrain, Egypt, Islamic Republic of Iran, Jordan, Kingdom of Saudi Arabia, Kuwait, Sultanate of Oman, Pakistan, Sudan, Qatar, United Arab Emirates, Yemen (12). European region: Belarus, Belgium, Bulgaria, Croatia, Denmark, Finland, France, Germany, Georgia, Greece, Hungary, Iceland, Ireland, Italy, Kazakhstan, Kyrgyzstan, Luxembourg, Malta, Portugal, Republic of Moldova, the Netherlands, Norway, Russian Federation, Serbia, Slovenia, Spain, Sweden, Switzerland, Tajikistan, United Kingdom of Great Britain and Northern Ireland (30). South East Asian region: Bhutan, Bangladesh, India, Indonesia, Thailand (5). Western Pacific region: Australia, China, Malaysia, Mongolia, the Philippines, Singapore, Viet Nam (7). My 5 Moments for Hand Hygiene QUESTIONANSWERHow does the "My 5 Moments for Hand Hygiene" approach relate to the indications for hand hygiene, contained within the WHO Guidelines on Hand Hygiene in Health Care (2009)?The My 5 Moments for Hand Hygiene approach incorporates all of WHOs recommendations for hand hygiene. The decision to address hand hygiene by focusing on five moments only is intended to make it easier to understand when there is a risk of pathogen transmission via the hands, to memorize them, and to assimilate them into the dynamics of health care activities. It is intended to reduce the number of times when hand hygiene occurs to the minimum for maximum safety.What, in summary, is the underlying theory of the "My 5 Moments for Hand Hygiene" approach?Indications for hand hygiene depend on the risk of germs transmission and are closely connected with the activities of healthcare workers within the geographical area surrounding each patient (patient zone) and with tasks they performs. Health-care activity is made up of a succession of tasks during which health-care workers hands touch different types of surfaces (patient, object, body fluid, etc). Depending on the order in which these contacts occur, pathogen transmission from one surface to another must be interrupted, as each contact is a potential source of contamination. It is during the interval between two contacts that the indication or indications for hand hygiene occur. The before indications are present when there is a risk of microbial transmission to the patient; the hand hygiene actions that correspond to these indications protect the patient. The after indications are present when there is a risk of microbial transmission to the health-care worker and/or to the health-care environment (and to any other person present); the hand hygiene actions that correspond to these indications protect health-care workers and the health-care environment and ultimately other patients. The right hand hygiene action at the right moment will contribute significantly to the maintenance of clean and safe care in the context of pathogens transmitted by hands. QUESTIONANSWERWhat is the difference between an indication, an opportunity and a moment for hand hygiene?The indication is the reason why hand hygiene is necessary at any given moment. It is related to the risk of pathogen transmission from one surface to another. There is an indication for hand hygiene whenever there is a risk of a health-care workers hands transmitting pathogens during health-care delivery. The risk of transmission may arise as a result of the risk of transmission from the health-care environment to the patient; from one body site to another in the same patient; or from the patient and the patient surroundings to the health-care worker and to the health-care environment (which includes everyone present in that setting). Indications relate to reference points in time i.e. before or after the contact. The indications before and after do not necessarily correspond to the beginning and end of a care sequence or activity. They occur during movements between geographical areas, during transitions between tasks near patients, between patients, or some distance from them. Five indications have been adopted and these constitute the fundamental temporal reference points for health-care workers: Before touching a patient, Before a clean/aseptic procedure, After body fluid exposure risk, After touching a patient and After touching patient surroundings. These five indications designate the moments when hand hygiene is required, in order to effectively interrupt pathogen transmission during care. The opportunity for hand hygiene is important when measuring compliance. It determines the need to perform the hand hygiene action, whether the reason (the indication that leads to the hand hygiene action) be single or multiple. From the point of view of the observer, the opportunity exists whenever one of the indications for hand hygiene is present and observed. At a simple level, each opportunity must be followed by a hand hygiene action (i.e. hand hygiene). Several indications may come together to create a single opportunity. What this means is that there may be several simultaneous reasons for a hand hygiene action. Health care safety depends on the hand hygiene action taken in response to the indications+ for hand hygiene, since hand hygiene makes it possible to prevent the risk of pathogen transmission. Details on indications and opportunities are given in the Hand Hygiene Technical Reference Manual, available at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/. QUESTIONANSWERWhy do the "My 5 Moments for Hand Hygiene" approach not include hand hygiene before touching furniture in the patients immediate vicinity?The "My 5 Moments for Hand Hygiene" approach has been prioritized on the basis of the risk of pathogen transmission. There is not an indication to perform hand hygiene before touching objects in the patient zone (bed frame, bedside table, patient table). The most important reason why is the fact that any object or surface in the patient's immediate surroundings is part of the "patient zone" and is considered to be contaminated by the patient's pathogens. The first indication is "Moment 1" Before touching a patient clearly indicating that on entering the patient zone (crossing a theoretical line which separates the patient zone from the health-care area- please see Hand Hygiene Technical Reference Manual), the indication is immediately before touching the patient. If the bedside table is touched, hand hygiene does not need to occur before this action. Hand hygiene should occur either when entering the patient zone and before touching the table and then touching the patient, or after touching the bedside table and immediately before touching the patient. In both cases the indication is Before touching a patient (Moment 1). Therefore when observing hand hygiene always remember each of the My 5 Moments for Hand Hygiene and ask the question "is what I am observing an indication for hand hygiene according to the "My 5 Moments for Hand Hygiene" approach? If "no", then there is no need for hand hygiene and for detecting it as a hand hygiene action. There is no indication "before patient environment"; so it is not necessary to clean hands before touching the patients environment. If you clean your hands while entering the patient zone, you may touch the environment and then touch the patient because hands will be contaminated only with that individual patients pathogens. In the event that the health-care worker touches the patients environment only and not the patient, hand hygiene must be performed on leaving the patient zone according to the moment "After touching patient surroundings". There may be some clinical settings where local adaptation of this particular aspect of the "My 5 Moments for Hand Hygiene" approach is necessary and we welcome feedback with regard to this. QUESTIONANSWERCan the "My 5 Moments for Hand Hygiene" approach be adapted or altered?If a hospital / country / professional association intends to adapt or modify the "My 5 Moments for Hand Hygiene" approach, for example, to add or remove one of the moments, WHO might be interested in supporting well-designed research strategies, and would consider working with the investigators to develop this. However, the potential unique selling point and added value that the "My 5 Moments for Hand Hygiene" approach offers, rests with the premise that it is an evidence-based, universally relevant concept. WHO would be concerned about changes that do not take heed of underlying evidence and thereby dilute the potential power of the "My 5 Moments for Hand Hygiene" approach, and undermine its role as a powerful campaigning tool.How do we apply the "My 5 Moments for Hand Hygiene" approach in situations where there is multiple bed-occupancy?Unfortunately circumstances can occur where more than one patient is sharing a patient environment / patient zone: either the same bed or the space around the bed. The resulting shared environment becomes a place where transmission of microbes may occur irrespective of hand hygiene. In these circumstances, the patients are likely to become colonized by the same microbes, irrespective of the frequency of hand hygiene. In these situations, conceptually there is one set of shared microbes within the patient environment. Is hand hygiene compliance important in these situations? The answer is a resounding "yes". The emphasis, however, shifts to Moments 2 and 3 for each individual patient, since compliance here is critical. When entering the "shared patient zone", compliance with Moment 1 applies. In a similar way, after contact with either or both of the patients, or leaving their environment, provides an indication for hand hygiene (Moments 4 and 5). However, logic dictates that when undertaking tasks within the patient environment, the indications before and after touching a patient, when moving from one patient to the other (in the same bed), may lose their importance. This is similar to the situation encountered when caring for a mother and baby.How do you apply the "My 5 Moments for Hand Hygiene" approach in situations where bed spacing is sub-optimal?The principles should still be applied, each bed having its own 'zone' around it, within which the "My 5 Moments for Hand Hygiene" approach applies. QUESTIONANSWERWhat are the hand hygiene indications during routine oral drug administration?According to the WHO Guidelines for Hand Hygiene in Health Care 2009, "before handling medication, perform hand hygiene using an alcohol-based handrub or wash hands with either plain or antimicrobial soap and water" (ranked 1B for evidence). There is no indication to clean hands before touching the medication storing cupboard. Hand hygiene should be performed (according to moment 2) before handling unpackaged medication.If any contact with the patient's intact skin or mucous membranes occurs, then hand hygiene will be required according to Moment 1 or 2, respectively. After, Moment 3 will occur after contact with the patient's mucousmembranes, or Moments 4 or 5 when leaving the patient zone after touching the patient or his/her surroundings. For more information, please see WHO Guidelines on Hand Hygiene in Health Care (2009) and the Hand Hygiene Technical Reference Manual available at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/Is there a hand hygiene indication between successive contacts while providing care for the same patient (without performing any aseptic task or any exposure to body fluids)?The "My 5 Moments for Hand Hygiene" approach assumes that the patient's flora rapidly contaminates the entire patient zone. Cross-transmission of patient's own flora between his/her intact skin surfaces or between a surface within the patient zone and intact skin is not considered as clinically significant, as long as there is no contact with a critical site with an infectious risk for the patient. For more information, please see WHO Guidelines on Hand Hygiene in Health Care (2009), the Hand Hygiene Technical Reference Manual, and other tools available at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/ and the following paper: "My five moments for hand hygiene" a user-centred design approach to understand, train, monitor and report hand hygiene. Sax H, Allegranzi B, Ukay I, Larson E, Boyce J, Pittet D. J Hosp Infect 2007;67:9-21Why can indications (moments) 4 and 5 never coincide to form one single opportunity?Indication (moment) 4 applies when the health-care worker leaves the patient's side after having touched the patient. If the health-care worker touches a patient's clothing or a surface following contact with the patient and before leaving the patient zone, indication (moment) 4 still applies. Indication (moment) 5 applies when the health-care worker leaves the patient zone after having touched only objects or inanimate surfaces, without touching the patient. Thus, when the health-care worker leaves the patient zone, he/she has either touched the patient (occurrence of indication 4) or has not (occurrence of indication 5). QUESTIONANSWERHow do you adapt the "My 5 Moments for Hand Hygiene" approach to mental health service patients?The My five moments for Hand Hygiene approach is based on the risk of germ transmission during health care activities. Each of the 5 indications for hand hygiene is defined according to different types of hand contacts during which the risk of germ transmission by hands occurs whatever the health care setting and regardless of the frequency of those contacts. This is a comprehensive, unified approach that is not meant to be subject to dramatic variations between different settings. The training can be adapted according to the specificity of mental health service care, but the approach itself should not be adapted unless new evidence is provided. For more information, please see the How, When and Why Hand Hygiene Brochure and the Hand Hygiene Technical Reference Manual available at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/.Should cleaning staff adhere to the "My 5 Moments for Hand Hygiene" approach?The crucial point influencing the approach is whether cleaning staff have contact with patients or not. During general cleaning activities, dedicated staff do not usually have contact with patients. Therefore, they are not concerned by the indications for hand hygiene (5 moments), which are not designed to fit into housekeeping activities. However: Cleaning staff should perform hand hygiene after glove removal (gloves should be domestic and not medical gloves) and in case of hands accidentally and visibly soiled with any body fluid or other material. Cleaning staff should perform hand hygiene after cleaning any object or furniture that are part of patient surroundings (moment 5), e.g., after cleaning the phone/handset located in the patient zone. Occasionally the tasks of ancillary/auxiliary workers may concern both health care and housekeeping activities. A very clear separation of activities should be then kept in mind during work sequences. When the professional is involved in care activities, then he/she should comply with the 5 moments requirements. If gloves are used for patient care activities, they must always be changed between individual patients contacts, i.e. when moving from one patient to care for another. Indications for their use and removal are as follows: Glove use: before a sterile condition anticipation of a contact with blood or another body fluid, regardless of the existence of sterile conditions and including contact with non-intact skin and mucous membrane contact with a patient (and his/her immediate surroundings) during contact precautions  QUESTIONANSWERGlove removal: as soon as gloves are damaged (or non-integrity suspected) when contact with blood, another body fluid, non-intact skin, and mucous membrane has occurred and ended when contact with a single patient and his/her surroundings, or a contaminated body site on a patient has ended when there is an indication for hand hygieneWhat level of hand hygiene should be adopted when carrying out an aseptic procedure, e.g. insertion of a central line?The "My five moments for hand hygiene" approach presents five essential indications (moments) when hand hygiene is required in order to prevent germ transmission; however, these do not refer to the various steps of specificcare procedures.For instance, during insertion of a central line (apart from the insertion of port and tunneled catheters, considered as surgical procedures) several indications for hand hygiene may occur (according to healthcare workers' hand contacts). Clearly the indication (moment) 2 "before clean/aseptic procedure" applies immediately prior to donning sterile gloves to insert a central venous catheter. Additional indications that may occur can be before touching the patient for palpation of the area for venous access, and/or after exposure risk to body fluids, which usually occurs after glove removal. For more practical examples on the "My five moments for hand hygiene"approach, please see the Hand Hygiene Technical Reference Manual available at  HYPERLINK "http://www.who.int/gpsc/5may/tools/training_education/en/index.html" \o "http://www.who.int/gpsc/5may/tools/training_education/en/index.html" http://www.who.int/gpsc/5may/tools/training_education/en/index.html.Is there specific advice regarding patients curtains when defining the patient zone and the health care area?The patient zone is not a static geographical area.It includes the patient and some surfaces and items that are temporarily and exclusively dedicated to him/her and are part of the patient's immediate surroundings. The "borders" of the patient zone are not physically defined by walls, privacy curtains, privacy screens or doors and are considered instead as part of the healthcare area, regardless of the type of room (single or multi-bedded). For more details,please see the practical example provided in section II.5.1 of the Hand Hygiene Technical Reference Manual available at  HYPERLINK "http://www.who.int/gpsc/5may/tools/training_education/en/index.html" \o "http://www.who.int/gpsc/5may/tools/training_education/en/index.html" http://www.who.int/gpsc/5may/tools/training_education/en/index.html. System Change Changing Hand Hygiene Behaviour at the Point of Care QUESTIONANSWERWhy is WHO placing great emphasis on alcohol-based handrubs at the point of care, and promoting them as the international standard for hand hygiene?The availability of a product which renders the hands safe in terms of transmission of pathogens, and which can be used at the very place where pathogens are transmitted, has revolutionized hand hygiene improvement strategies in the modern age. For this reason, alcohol-based handrubs are considered to fulfil the highest standards of safety in relation to the prevention of cross-transmission. At the present time, the most efficacious, well-tolerated and well-researched product that can be placed ergonomically and safely at the point of care is an alcohol-based handrub. This System Change facilitates the right action to occur at the right time and in the right way. It is unlikely, although not impossible, that running water, soap and towels will be installed right next to each patients bed, or be available at the point of care in an affordable and practical way. Soap and water handwashing is however less efficacious, more time-consuming, and less well tolerated by skin than alcohol-based handrubbing. In countries where access to sinks is limited or non-existent, alcohol-based handrubs offer a method of preventing cross-transmission which can be implemented in the short term alongside a longer-term strategy of sink installation.Is WHO suggesting that health-care workers are no longer required to use soap and water?No. The WHO Guidelines on Hand Hygiene in Health Care (2009) promote hand hygiene compliance per se. The facts are as follows: when an alcohol-based handrub is available, it should be used as the first choice for hand hygiene (of non-soiled hands) since it enables health-care workers to optimally comply with recommended indications at the point and moment of care. However, the WHO Guidelines on Hand Hygiene in Health Care (2009) and all training materials emphasize that hands need to be washed with soap and water when visibly dirty or visibly soiled with blood or other body fluids or after using the toilet. If exposure to potential spore-forming organisms is strongly suspected or proven, including outbreaks of Clostridium difficile, handwashing with soap and water is the preferred means. Therefore, WHO supports sink installation programmes and access to water supplies, soap, and towels, within health-care settings. QUESTIONANSWERIs it true that alcohol-based handrubs are not effective against some important pathogens, for example, Clostridium difficile and norovirus?Clostridium difficile: no agent used in hand hygiene preparations, including alcohol-based handrubs, is effective against the spores of C. difficile. Contact precautions are highly recommended during C. difficile-associated outbreaks, in particular, glove use (as part of contact precautions) and handwashing with a non-antimicrobial or antimicrobial soap and water following glove removal after caring for patients with diarrhoea. Alcohol-based handrubs can then be exceptionally used after handwashing in these instances, after making sure that hands are perfectly dry. Norovirus: This is an unresolved issue. There are studies which showed that 70% ethanol with 30-second exposure was superior to the other alcohol solutions in terms of virucidal activity. However, there is no evidence demonstrating its superiority to soap. Whether alcohol is effective against microbes such as C. difficile and norovirus can divert attention from a much overlooked issue. Alcohol-based handrubs play a critical role in mass behaviour change and health improvement. Discouraging their widespread use in response to diarrhoeal infections, will only jeopardize overall patient safety in the long term. Apart from C. difficile outbreaks, alcohol-based handrub should be used in all other instances, providing a constant safety net to protect patients from the multitude of harmful resistant and non-resistant organisms transmitted by the hands of health-care workers.What does 'point of care alcohol-based handrub' mean in practice?Making alcohol-based handrub available at the point of care means making it available at the exact place where care or treatment involving physical contact between a patient and a health-care worker takes place (as illustrated within the "My 5 Moments for Hand Hygiene" approach). Point-of-care products should be accessible without leaving the patient environment ("My 5 Moments for Hand Hygiene" approach). This enables health-care workers to make hand hygiene habitual and quickly and easily take action to ensure compliance in relation to the indications corresponding to the "My 5 Moments for Hand Hygiene" approach, thus killing the pathogens and preventing their spread. It is important to understand that the product must be capable of being used without leaving the patient zone (i.e. it must be within the dotted line denoting the patient zone as illustrated through the Your 5 Moments for Hand Hygiene poster). Point of care is usually achieved through health-care worker-carried handrubs (pocket bottles) or handrubs fixed to the patient's bed, bedside table or to the wall next to the patient's bed. Handrubs affixed to an object e.g. trolleys, or dressing or medicine trays which are taken into the patient environment, can also fulfil this definition, if they are reliably taken into the patient zone in anticipation of contact.QUESTIONANSWERShould hand hygiene be performed prior to donning non-sterile gloves?Hand hygiene should be performed regardless of the use of gloves (whether non-sterile or sterile) when an indication for hand hygiene applies. That means: hand hygiene must be performed before donning gloves, if the following care activity implies an indication for both hand hygiene, such as before touching a patient or before a clean/aseptic procedure, and using gloves. The fact of donning gloves by itself does not constitute an indication for hand hygiene (for example, you may put on gloves just to handle contaminated material for your own protection, without touching the patient or undertaking an aseptic procedure). It is important to clarify also that glove use should be limited only to real indications. Gloves are often overused and consequently a "false" sense of security might induce the health-care worker to omit hand hygiene when indicated. Glove use indications were reviewed by WHO and summarized in the Glove Use Information Leaflet available at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/.Can alcohol be used on gloved hands?It is very important that health-care workers allow the alcohol to dry properly before donning gloves, and that they clean their hands again after removing them, if indicated. It is not recommended that health-care workers use the alcohol-based handrub whilst gloves are on their hands.What are the recommendations in relation to jewellery and fingernails?Several studies have shown that skin underneath rings is more heavily colonized than comparable areas of skin on fingers without rings. The consensus recommendation is to strongly discourage the wearing of rings or other jewellery during health care. If religious or cultural influences strongly condition the health-care workers attitude, the wearing of a simple wedding ring (band) during routine care may be acceptable, but in high-risk settings, such as the operating theatre, all rings or other jewellery should be removed. Consensus recommendations regarding fingernails are that health-care workers do not wear artificial fingernails or extenders when having direct contact with patients and natural nails should be kept short (d"0.5 cm long or approximately inch long). QUESTIONANSWERIf health-care workers are not familiar with alcohol-based handrubs at the point-of-care what approach should be taken to convince them of its effectiveness?In the early days of alcohol-based handrub, there was a perception amongst some health-care workers that this was a less effective way to clean the hands than, for example, using soap and water. In fact, some health-care workers may have been taught that hands should be washed with soap and water prior to applying alcohol. Today, the evidence very clearly supports the view that it is perfectly acceptable and indeed preferable to use an alcohol-based handrub on its own (without a prior handwash) as long as the hands are clean to the naked eye, and there has not been contact with body fluids or spore-forming pathogens. Alcohol-based handrubs are efficacious, time saving and kinder to the skin than soap and water. They increase the reliability and likelihood of compliance occurring, and have a high impact on reducing the burden of health care-associated infection. In summary, many studies comparing alcohol-based handrubs with antibacterial soap and water demonstrated that alcohol rubs reduced bacterial and viral counts on the hands to a greater degree than antimicrobial soaps.When using pocket bottles of alcohol-based handrubs, can bottles (or health-care workers' gowns) become contaminated? Does this affect hand hygiene action?The potential contamination of pocket bottles and health-care workers' gowns can occur. However, this does not pose a problem for hand hygiene action as hands are always rubbed after touching the bottles. Affixed or wall-mounted dispensers can also get contaminated.What are recommendations of WHO regarding health-care workers wearing long sleeves?Long-sleeved coats may become contaminated by microorganisms during patient care. Although evidence as a recommendation is limited, long sleeves should be avoided. QUESTIONANSWERDoes WHO make any recommendation on the use of non-alcohol-based handrubs?At present, there appears to be minimal literature on the use of non-alcohol-based handrubs and this should be considered when making recommendations. Any health care institution intending to use a non-alcohol-based handrub should verify the following points: efficacy of the product within a short time e.g. 30 seconds or less because time is an important factor of adherence to the "My 5 Moments for Hand Hygiene" approach. tolerance and toxicity of their components and user acceptability. It is also important that the product passes European test standards. If these criteria are met, products can be introduced by a healthcare institution, but constant review and feedback is important. The WHO Guidelines set standards and as such do not feature recommendations for these products due to the current lack of evidence and these internationally-accepted guidelines should be considered in decision making. However new, well formulated, in vivo testing of products is always welcomed.Can ash and mud be used for hand washing in health-care settings where soap is lacking?The First Global Patient Safety Challenge team does not recommend the use of ash or mudfor hand hygiene in health care.The use of fresh lemon juice can be considered if nothing else is available as the citric acid content is bactericidal, but its efficacy has not been studied. In situations of cholera outbreaks, the use of boiled water and liquid soaps for hand sanitation should be recommended when alcohol-based handrubs are not available. The use of alcohol-based handrub is the preferred means for routine hand hygiene in health care unless hands are visibly dirty or soiled with blood or other body fluids or after using the toilet in which cases handwashing with soap and water is recommended. For more details, please see Part II of the WHO Guidelines on Hand Hygiene in Health Care (2009). Alcohol-based Handrub: Formulation & Production QUESTIONANSWERWhy are WHO-recommended formulations suitable for health-care workers?The recipes for two different formulations have undergone significant testing in a number of countries (formulation I is an ethanol-based handrub; formulation II is an isopropyl-based handrub). The formulations contain also glycerol to protect hands, as well as a specific ingredient that eliminates contaminating spores from components or reused bottles (hydrogen peroxide). The microbicidal activity of the two WHO-recommended formulations was tested by a WHO reference laboratory according to EN standards (EN 1500). Their activity was found to be equivalent to the reference substance (isopropanol 60% v/v) for hygienic hand antisepsis. The recipe is available for those facilities which at present do not have access to commercially available alcohol-based handrub due to logistical or cost issues, or would prefer to undertake local production instead of procurement from the market. WHO is in no way suggesting that health-care facilities with access to efficacious, well-tolerated products should switch to the WHO formulation.Who will make WHO-recommended formulations?The formulation can be manufactured within an individual health-care facility with a pharmacy laboratory on-site. However, in some instances, local companies with the correct facilities are manufacturing the WHO formulation on behalf of the health-care facility or for national production.Will current manufacturers lose business?Offering a validated procedure for local production of alcohol-based handrubs to those settings that do not currently have the finances or infrastructure to purchase commercial products, will not have an impact on current global business of alcohol-based handrub manufacturers.What incentives will there be to use the WHO formulation?The incentive for a health-care facility that is committed to improve hand hygiene to use the WHO formulation is that it is a quality product, which can become affordable. The WHO formulation makes available a product that is fast-acting, effective and well tolerated by health-care workers, usually in a context where no alternative commercial product is available, or not available at an affordable price. In a randomized cross-over trial the short-term skin tolerability and acceptability of WHO-recommended handrub formulations were significantly higher than those of a reference product. Tolerability and acceptability information were available from four sites (Bangladesh, Hong Kong SAR, Pakistan and Saudi Arabia) where, in general, WHO-recommended formulations were well appreciated by health-care workers. In Hong Kong SAR and Pakistan, WHO-recommended formulations were preferred to the product previously in use because of better tolerability.  QUESTIONANSWERCan a health-care facility produce alcohol-based handrub and then distribute to nearby hospitals?This should be decided locally and under the scrutiny of governing bodies in the region. If this offers a reliable way of ensuring widespread availability of the product, then WHO would welcome such an approach.It is suggested that the WHO-recommended alcohol-based handrub should be produced in quantities not exceeding 50 L. Is it possible to exceed this volume?If the alcohol-based handrub is being produced in a small hospital facility or in central pharmacies lacking specialized air conditioning and ventilation, it must not be produced in quantities exceeding 50 L. However, if the formulation is being produced on behalf of a health-care facility, by a commercial company with good laboratory and safety facilities, then it can be produced in larger quantities exceeding 50 L. The reason for limiting production to no more than 50 L at a time is to minimize fire hazards.If distilled water is not available, what would be an appropriate substitute for the preparation of WHO-recommended formulations?Although sterile distilled water is preferred for making the formulations, boiled and cooled tap water or deionized sterile water may also be used as long as it is free of visible particles.How long does the alcohol-based handrub remain active?The 'shelf life' of WHO-recommended formulations, produced according to the Guide to Local Production: WHO-recommended Handrub Formulations, is at least 2 years after production. There may be some variability depending on local storage temperatures. However, the WHO formulation tested for quality control in Mali up to 19 months after production, met the optimal quality parameters. The key to producing a high-quality product is adherence to general rules of good manufacturing practices. Longevity is also dependent upon the alcohol being stored as recommended in the Guide to Local Production: WHO-recommended Handrub Formulations document.If a facility locally produces one of the WHO-recommended formulations, is it necessary to test the product according to the requirements of CEN and ASTM?WHO-recommended formulations should be produced in a pharmacy or a laboratory following instructions included in the Guide to Local Production: WHO-recommended Handrub Formulations. If the instructions are carefully followed, including the quality control test on the final production, it is not necessary to test according to CEN and ASTM norms. If the alcohol is bought from a reputable company, the concentration stated should be exact and it should be achievable to correctly make up the recommended concentration in the final product (ethanol 80% v/v and isopropyl alcohol 75% v/v). If ethanol is produced locally, then checks of its concentration should be made to determine its exact concentration before producing the alcohol-based handrub. QUESTIONANSWERHow do you quality control the locally produced WHO-recommended formulations?Especially if concentrated alcohol is obtained from local production, checks of the final alcohol concentration in the formulations after manufacturing should be undertaken and, if necessary, adjustments in volume to obtain the final recommended concentration should be made. An alcoholmeter can be used to control the alcohol concentration of the final use solution; H2O2 concentration can be measured by titrimetry (oxydo-reduction reaction by iodine in acidic conditions). A higher level quality control can be performed using gas chromatography and the titrimetric method to control the alcohol and the hydrogen peroxide content, respectively. Moreover, the absence of microbial contamination (including spores) can be checked by filtration, according to the European Pharmacopeia specifications.  Alcohol-based Handrub: Risks / Hazards QUESTIONANSWERWill over-use of alcohol-based handrubs result in resistance?Unlike other antiseptics and antibiotics, there is no evidence on reduced susceptibility of pathogens to alcohol-based handrubs. Does alcohol dry the hands or sting when applied?Modern alcohol-based handrubs should not (if used correctly) dry the hands. Some health-care workers may be familiar with the generation of alcohol-based handrubs which contained no skin softeners (humectants). Todays handrubs all contain skin softeners which help prevent drying. Several studies have shown that nurses who routinely use alcohol rubs have less skin irritation and dryness than those using soap and water. Alcohol-based handrubs will sting if the health-care worker has any cuts or broken skin. Such areas should be covered with waterproof plasters. Allergic contact dermatitis due to alcohol-based handrubs is extremely rare in contrast to reactions to soaps. Alcohol-based handrubs should not be used concomitantly to detergents or soaps for routine hand hygiene.How many times can health-care workers use the alcohol-based handrubs?There is a common misconception that hands should be washed after every four or five applications of alcohol-based handrub. There is no reason to do this, other than personal preference in some cases (i.e. if hands feel like they need washing or in hot and highly humid climates), while taking into account, though, that alcohol-based handrubs and soap should not be used concomitantly.Are there any special hazards associated with WHO-recommended formulations?WHO-recommended formulations of handrub should not be produced in quantities exceeding 50 L locally or in central pharmacies lacking specialized air conditioning and ventilation. Since undiluted ethanol is highly flammable and may ignite at temperatures as low as 10C, production facilities should directly dilute it to the concentrations outlined in the Guide to Local Production: WHO-recommended Handrub Formulations. The flash points of ethanol 80% (v/v) and isopropyl alcohol 75% (v/v) are 17.5C and 19C respectively.How to fight a large (i.e. bulk storage) alcohol fire?Water or aqueous (water) film-forming foam (AFFF) should be used; other types of extinguishers may be ineffective and may spread the fire over a larger area rather than put it out. QUESTIONANSWERAre you aware of any problems with patients or health-care workers drinking the product?There have been some reports from countries of patients or health-care workers drinking alcohol-based handrubs. This is clearly a concern when considering large-scale implementation of these products, and risks should be satisfactorily addressed. A thorough risk assessment should be undertaken including the following: In areas where there is thought to be a high risk of ingestion by patients, health-care worker carried product is advised If wall-mounted product is used, consideration should be given to small bottles If bottles greater than 500 ml are used, consideration should be given to providing in secured containers Consideration should be given to labelling of the handrubs to make the alcohol content less clear at a casual glance and to add a warning against consumption National and local toxicology specialists should be involved in developing and issuing national/local guidance on how to deal with ingestion (based on products available within a country) In general, it is not recommended to add bittering agents, however, in exceptional cases where the risk of ingestion might be very high (paediatric or confused patients), substances such as methylethylketone and denatonium benzoate) may be added to reduce the risk of accidental or deliberate ingestion. However, there is no published information on the compatibility and deterrent potential of such chemicals when used in alcohol-based handrubs to discourage their misuse. It is important to note that such additives may make the products toxic and add to production costs. In addition, the bitter taste may be transferred from hands to food being handled by individuals using handrubs containing such agents. Therefore, compatibility and suitability, as well as cost, must be carefully considered before deciding on the use of such bittering agents. It is important to ensure that placement of the handrubs is targeted at the points of care. Many of the risks associated with alcohol-based handrubs can be further minimized by sensible location of the bottles, aligned with the "My 5 Moments for Hand Hygiene" approach and point of care philosophy.How should used bottles be disposed?Used containers and dispensers will contain handrub residues and flammable vapours. Rinsing out used containers with copious amounts of cold water will reduce the risk of fire and the containers may then be recycled or disposed of in general waste. QUESTIONANSWERAre health-care workers adversely affected in any way by alcohol-based handrubs?There is no evidence to suggest systemic adverse effects. Published studies to date have shown that after using the handrubs, alcohol levels found in the blood are insignificant. Skin dryness is uncommon with modern alcohol-based handrubs, since they all contain an emollient agent. Allergic contact dermatitis and bleaching of hand hair due to alcohol are very rare adverse effects. For alcohol absorption by inhalation, please see the question What advice do you have in light of the reports that some countries are considering banning ethanol due to theoretical harmful effects caused by absorption through intact skin or inhalation? below. What advice do you have in light of the reports that some countries are considering banning ethanol due to theoretical harmful effects caused by absorption through intact skin or inhalation?Recently, the Health Council of the Netherlands suggested to classify ethanol as carcinogenic because of the fear of an increased risk of breast and colorectal cancer in persons with an occupational exposure to ethanol. Absorption of alcohol exceeding certain levels may result in toxicity and chronic disease in animals and humans. Alcohols can be absorbed by inhalation and through intact skin, although the dermal uptake is very low. There are no data to show the use of alcohol-based handrub may be harmful and studies evaluating the absorption into blood show that it is not. However, WHO recommends that individual facilities follow their Government's directives.Can Muslim health-care workers use alcohol-based handrubs?In some religions, alcohol use is prohibited or considered an offence requiring a penance (Sikhism), or is considered to cause mental impairment (Hinduism, Islam). Nonetheless, in theory, those religions with an alcohol prohibition in everyday life demonstrate a pragmatic vision which is followed by the acceptance of the most valuable approach in the perspective of optimal patient-care delivery. Indeed any substance that man can manufacture or develop in order to alleviate illness or contribute to better health is permitted by the Qur'an and this includes alcohol used as a medical agent. No serious obstacles to the promotion of the use of alcohol-based handrubs have been reported to WHO. As an example to understand Muslim health-care workers attitudes to alcohol-based hand cleansers in an Islamic country, no difficulties or reluctance were encountered in the adoption of alcohol-based handrubs at the King Abdul Aziz Medical City (KAAMC) in Riyadh, Kingdom of Saudi Arabia (Ahmed et al, Lancet 2006). At the KAAMC, the policy of using alcohol handrub is not only permitted, but has been actively encouraged in the interest of infection control since 2003. No state policy or permission or fatwa (Islamic religious edict) were sought for approval of the use of alcohol-containing handrubs, given that alcohol has long been a component present in household cleaning agents and other materials for public use, including perfume, without legislated restriction within the Kingdom. In all these instances, the alcohol content is permitted because it is not for ingestion.  QUESTIONANSWERWhat are the fire hazards relating to alcohol-based handrub?A recent study conducted in Germany found an estimated total handrub use of 25,038 hospital years, representing an overall consumption of 35 million L for hospitals studied. A total of seven non-severe fire incidents were reported in this study. In another study in the USA, none of 798 health-care facilities surveyed reported a fire related to alcohol-based handrub dispenser. Therefore, the risk of fires associated with such products is very low. However, alcohols are flammable and therefore the WHO Guidelines on Hand Hygiene in Health Care (2009) recommend the following: Involve fire officers, fire safety advisors, risk managers, health & safety and infection control professionals in risk assessments prior to embarking on system change. Risk assessment should address: The location of dispensers The storage of stock The disposal of used containers / dispensers and expired stock. Storage: store away from high temperatures or flames. Drying: following application of alcohol-based handrubs, hands should be rubbed together until all the alcohol has evaporated (once dry, hands are safe).Some experts state that isopropyl alcohol is not suitable for the preparation of alcohol-based handrubs due to potential eye irritation and narcotic properties. Is that correct?Isopropanol is classified as an irritant for eyes and mucous membranes. However, this adverse effect happens when in direct contact with the liquid or high concentrations of the vapour in the air. There are national recommendations as to the exposure limits that range from 200 ppm to 500 ppm over an 8-hour period. This generally applies to individuals working with isopropanol. To our knowledge, there has been no report or publication citing isopropanol as an occupational hazard for health-care workers when used as a hand antisepsis agent. Some studies investigating this issue are as follows: Lffler H et al. Hand disinfection: how irritant are alcohols? J Hosp Infect 2008 Oct. 70 suppl 1:44-48. Turner P et al. Dermal absorption of isopropyl alcohol from a commercial hand rub: implicatiojns for its use in hand decontamination. J Hosp Infect 2004:56:287-290. Pedersen L K et al. Short-term effects of alcohol-based disinfectant and detergent on skin irritation. Contact Dermatitis 2005: 52:82-87. Kramer A et al. Quantity of ethanol absorption after excessive hand disinfection using three commercially available hand rubs is minimal and below toxic levels for humans. BMC Infectious Diseases: 2007: 7:117.QUESTIONANSWERWhere should alcohol-based handrubs be stored?Local and central (bulk) storage must comply with the fire regulations regarding the type of cabinet and store respectively. Production and storage facilities should ideally be air-conditioned or cool rooms. No naked flames or smoking should be permitted in these areas. National safety guidelines and local legal requirements must be adhered to for the storage of ingredients and the final product. Care should be taken when carrying personal containers / dispensers, to avoid spillage onto clothing, bedding or curtains and in pockets, bags or vehicles. Containers / dispensers should be stored in a cool place and care should be taken regarding the securing of tops / lids. The quantity of handrub kept in a ward or department should be as small as is reasonably practicable for day-to-day purposes. A designated Highly Flammables store will be required for situations where it is necessary to store more than 50 L (e.g. central bulk storage). Containers and dispenser cartridges containing handrub should be stored in a cool place away from sources of ignition. This applies also to used containers which have not been rinsed with water.Where should dispensers be located while taking fire hazards into account?Handrub dispensers should not be placed above or close to potential sources of ignition, such as light switches and electrical outlets, or next to oxygen or other medical gas outlets, due to the increased risk of vapours igniting. The placement of handrub dispensers above carpets is not recommended due to the risk of damage and lifting / warping of carpets. Consideration should be given to the risks associated with spillage onto floor coverings, including the risk of pedestrian slips.Should any special instructions be given to patients and visitors?Clear instructions for use should be displayed at handrub dispenser points intended for use by visitors. These should include warnings not to use excessive amounts, and not to smoke immediately after use.How should spillages be managed?Significant spillages should be dealt with immediately by removing all sources of ignition, ventilating the area and diluting with water (to at least 10-times the volume). The fluid should then be absorbed by an inert material such as dry sand (not a combustible material such as sawdust) which should then be disposed of in a chemical waste container. Vapours should be dispersed by ventilating the room (or vehicle) and the contaminated item should be put in a plastic bag until it can be washed and/or dried safely. Patient Involvement and Empowerment QUESTIONANSWERIs it appropriate to encourage patients to remind health-care workers to clean their hands?Yes. The WHO Guidelines on Hand Hygiene in Health Care (2009) recommendation states: "Encourage partnerships between patients, their families and health-care workers to promote hand hygiene in health-care settings. The WHO Guidelines on Hand Hygiene in Health Care (2009) now contains an entire chapter on Patient Involvement in Hand Hygiene Promotion. The chapter outlines some of the considerations when embarking on this approach and a template strategy for developing an empowerment programme. Additional guidance and suggestions on engaging patients in hand hygiene can be found in the document Guidance on Engaging Patients and Patient Organizations in Hand Hygiene Initiatives on the WHO Patient Safety website at  HYPERLINK "http://www.who.int/gpsc/5may/en/" www.who.int/gpsc/5may/en/.What role do patients play in the spread of infection?The "My 5 Moments for Hand Hygiene" approach illustrates in a simple manner the times when hand hygiene should be undertaken in health care, based on the dynamics of pathogen transmission. Patients themselves can transfer pathogens from one site of their body to another. If patients are having contact for example with their wound or the insertion site of a device, hand hygiene should be encouraged and the patient be taught (the alcohol-based handrubs will enable easy hand hygiene to be performed). Some health-care facilities actively promote hand hygiene by all health-care workers and visitors entering a ward is this a good approach?Many health-care facilities use this approach, which seems logical. However, before embarking on such a strategy it is very important to consider whether such an approach is in line with the "My 5 Moments for Hand Hygiene" approach. Encouraging unnecessary hand hygiene should not be done at the cost of timely and appropriate hand hygiene by health-care workers at the point of care. Local decisions which best suit local contexts should be taken.      PAGE  Page  PAGE 1 of  NUMPAGES 47      Page  PAGE 13 of  NUMPAGES 47 Revised May 2010 All reasonable precautions have been taken by the World Health Organization to verify the information contained in this document. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this document. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this document. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this document. 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