ࡱ> ~7 x?bjbjUU "7|7|x;l$$$$$$$8****D*8!5n+n+n+n+n+n+n+n+4444444$6 84$n+n+n+n+n+44$$n+n+4444n+$n+$n+44n+4444$$4n+b+ Ã<8Z)*404440!549494488$$$$LYRICS AND CREDITS FOR STEREO ISOMERS (2002) BY CROWTHER ET AL. 1. The Waltz Of The Ribosomes words and music by Greg Crowther, 2001-2002 performed by Gregorio del Laboratorio, 2002 T G G, C T T, G G & A. The DNA bases are the letters I say. A T G, A C C, A G & C. Theyre part of a gene from the family tree. A C C, G A A, C C & U. Transcription of DNA is easy to do. U A C, U G G, U C & G. The As go with Us, and the Gs go with Cs. Threonine, glutamic acid, and proline. The mRNA gets translated to protein. Tyrosine, tryptophan, serine, and stop! Translation is halted by a stop codon cop. What have we heard here, and what have we learned? Theres DNA, RNA, and protein in turn. RNAs copied from DNA strands, And protein is built using RNA plans. Such is the way by which cells can make hay From T G G, C T T, G G & A. 2. Building A Histidine a parody of the song Building A Mystery written by Sarah McLachlan and Pierre Marchand and recorded by Sarah McLachlan new lyrics by Greg Crowther, 1999 performed by Jessica Raaum (vocals) with Sound Choice (karaoke accompaniment), 2002 It comes in your food; thats what the textbooks say. But you cant be subdued until the next meal. Youve got some ribose and a few carbonyls, And you're going to take a break from your normal routine.... Youre building a histidine. You live in a cell, where you sleep with organelles, And you wont give up on the synthesis, though its not going well. The R group buffers you cause it has the perfect pKa; Can you really create it without thermodynamics getting in the way? Its not difficult to form these amino acids. Youre so clueless; maybe you need some classes.... Cause youre working, building a histidine. Hold on -- that looks like alanine. Yeah, youre working, building a histidine like those youve seen in Science magazine. You woke up screaming aloud: Pray for more histidine, cause, without that guy, my globins will die! We can't make protein without imidazole rings. The ribosomes just sit there; they cant do a thing. Its not difficult to form this residue. E. coli does it, so tell me, whats wrong with you? Cause youre working, building a histidine. Hold on -- thats more like arginine. Yeah, youre working, building a histidine like those youve seen in Science magazine. Ooh, youre working, building a histidine. Hold on -- that looks like tyrosine. Yeah, youre working, building a histidine like those youve seen in Science magazine. Yeah, youre working, building a histidine. Hold on -- thats gotta be glutamine. Oh yeah, youre working, building a histidine like those youve seen in Science magazine. Youre building a histidine. 3. The Professor And The Punk words and music by Greg Crowther, 1999 performed by Gregorio del Laboratorio (vocals, keyboards) and Do Peterson (vocals, percussion), 1999 [PUNK: ] I know Ive got a top-notch brain, but no one even knows my name. What I need is a brand-new look: a cover thatll make you want to read the book. Though I hesitate to stick out my neck, if I cant get your attention, how can I get your respect? So I'm gonna be a rebel, sad as it sounds, cause whatever's on the outside is what really counts. Im gonna get a nose ring; Im gonna have neon hair. Im gonna be famous for how I look and what I wear. I get no attention in this dark limousine, so take me out in public, where I can be seen. Yes, take me out in public, where I can be seen. [PROF: ] Every generation thinks its so outrageous, but it's just a new cover on the same old pages. I dont want to be flashy like the hip-hop youth; my beat is discovering the fundamental truths. Reductionism is my philosophical stance; if I dissect a specimen, my knowledge will advance. I break the sample down to its innermost ounce, cause whatevers on the inside is what really counts. Im gonna get tenure; Im gonna get a Nobel Prize. Im gonna be famous for the proteins I have crystallized. I get no work done in this fancy hotel, so take me back to lab, where I can study my cells. Yes, take me back to lab, where I can study my cells. [PROF: ] In this time of tabloids and sound-byte sales, its nice to know that sanity usually prevails. [PUNK: ] Ah, flamboyance is in, and modesty is out; if you want to be heard, youve got to shout! [PROF: ] I can hear you just fine, but youre trying my patience, cause theres not a lot of thought behind your grand proclamations. [PUNK: ] But this isnt just a scientific battle to be won, so cmon, lighten up, man, have a little fun! [PROF: ] Im gonna get tenure.... [PUNK: ] Im gonna have neon hair.... [PROF: ] Im gonna be famous.... [PUNK: ] ... As Dr. Geek Extraordinaire. [PROF & PUNK: ] Its hard to get noticed, and its easy to flop, But Ill take on this crummy world and come out on top. Yes, Ill take on this crummy world and come out on top. 4. Organic Chemistry a parody of the song Breakfast At Tiffanys written and recorded by Deep Blue Something new lyrics by Greg Crowther, 2001 performed by Eric Chase (lead vocals, guitar) and Gregorio del Laboratorio (backing vocals), 2002 You say, What these two atoms have in common Is this shared pair of electrons to keep them from falling apart. You say, A bond is formed between them -- A covalent bond connects them -- now I wonder where I learned that. CHORUS: And I said, What about Organic Chemistry? She said, I think I remember the class, And, as I recall, I think we both kinda liked it. And I said, Well, I can tell that you passed. I see, she said. So weve got this carbon compound Of unknown chemical structure with an unknown set of bonds. These bonds, she said -- if you want to detect them, You should take an IR spectrum. I once had a lab like that. CHORUS You say, What these two atoms have in common Is this shared pair of electrons to keep them from falling apart. You say, A bond is formed between them -- A covalent bond connects them -- now I wonder where I learned that. CHORUS [twice] 5. Glucose, Glucose a parody of the song Sugar, Sugar written by Jeff Barry and Andy Kim and recorded by The Archies new lyrics by Greg Crowther, 1999 performed by Sam Reid (lead vocals) with Cecilia Broadway, Diane Garst, and Belen Villarreal (backing vocals), 2000 Glucose -- ah, sugar sugar -- You are my favorite fuel from the blood-borne substrate pool. Glucose -- monosaccharide sugar -- Youre sweeter than a womans kiss cause I need you for glycolysis. I just cant believe the way my muscles take you in. (For you, theyll open the door.) All it takes is a little bit of insulin (To upregulate GLUT4). Ah, glucose -- ah, sugar sugar -- You help me make ATP when my predators are chasing me. Ah, glucose -- you're an aldehyde sugar, And youre sweeter than a woman's kiss cause I need you for glycolysis. I just cant believe the way my muscles break you down. (My glycogen is almost gone.) A few more seconds and Ill be rigor mortis-bound. (Acidosis done me wrong.) Your sweet is turning sour, baby. Im losing all my power, baby. Im gonna make your muscles ache. No, no, no! Im swimming in lactate, baby. Yes, Im swimming in lactate, baby. Now I'm drowning in lactate, baby. Im gonna make your muscles ache. No, no, no! Im drowning in lactate, baby. Ah, glucose -- ah, sugar sugar -- I used you up and you left me flat; now Ill have to get my kicks from fat. Oh, glucose, glucose, sugar, sugar, the honeymoon is over now. 6. The Nucleus I Like Best words and music by Greg Crowther, 2001 performed by Gregorio del Laboratorio (vocals, keyboard) and Do Peterson (guitar) with Denise Echelard and Jerry Ortiz (scanner percussion), 2001 Theres 15N, 39K, 19F, and also 13C, But of all the atoms East to West, the nucleus I like best is 31P. Proton spins are everywhere, and MRI reveals their density. But all that leaves me unimpressed; the nucleus I like best is 31P. Take a limb, get it shimmed, and sample from the muscles that you see. A spectrum lets you quantify the PCr, Pi, and ATP. Cell pH can be deduced from the inorganic phosphate frequency; You can likewise measure magnesium using the chemical shift of ATP. If you scan a leg or hand during stimulation and recovery, The spectra let you find the rates of using and creating ATP. Now NMR can take you far beyond this type of phosphate chemistry, But Ive come clean and Ive confessed -- the nucleus I like best is 31P. 7. Thats What Slugs Are For a parody of the song Thats What Love Is For written by Michael Omartian, Mark Muller, and Amy Grant and performed by Amy Grant new lyrics by Greg Crowther, 1997 performed by Jessica Raaum (vocals) with Sound Choice (karaoke accompaniment), 2002 Sometimes experiments are easy to design. Well take the perfect mollusks And use recordings from their nerve cells, just like Eric Kandel, To explain why they behave as they do. Sometimes I wonder if our methods are humane. We can be so unkind, Squirting water at their siphon until they withdraw their gill. They always get their fill of this sadistic drill, cause.... Thats what slugs are for: to test our theories. Thats what slugs are for: to answer queries. Map out the wiring, observe neurons firing, give us circuits to explore -- Baby, thats what slugs are for. Sometimes I wonder if we can really use these slugs to learn about mankind, But compare the two and you will observe many traits are conserved, And from slugs and squids to hominids, a nerve is still a nerve.... And thats what slugs are for: to give us data. Thats what slugs are for; they can really aid ya. Its a small set of neurons, and theyre easy to turn on. Demonstrating less is more -- Baby, thats what slugs are for. This much is true according to our anthropocentric view.... Thats what slugs are for: to test our theories. Thats what slugs are for: to answer queries. Map out the wiring, observe neurons firing, get us funding when we're poor -- Baby, thats what slugs are for. 8. Twinkle, Twinkle, T2* a parody of The Star written by Ann and Jane Taylor new lyrics by Greg Crowther, 2001 performed by Do Peterson (vocals) and Gregorio del Laboratorio (electronic harpsichord), 2002 Twinkle, twinkle, T2*; how I wonder what you are! XY signal soon decays; why do the spins go out of phase? Twinkle, twinkle, T2*; something pulls those spins apart. Spin-spin crosstalk sets T2, but by then T2* is through. A brief duration here is sealed by an inhomogeneous field. Twinkle, twinkle, T2*; now I know just what you are! Twinkle, twinkle, T2*; how I wonder what you are! XY signal soon decays; why do the spins go out of phase? Twinkle, twinkle, T2*; something pulls those spins apart. 9. Take Me To The Liver a parody of the song Take Me To The River written by Al Green and Mabon Teenie Hodges and recorded by Talking Heads new lyrics by Greg Crowther, 1996 performed by Gregorio del Laboratorio (lead and backing vocals), Do Peterson (lead and backing vocals, guitar, shaker), and Craig Epifanio (shouting), 1996 I know why I need you like I do: all the lymph and plasma youll bring me through. Im a fat hitch-hiker whos afraid to get wet; if I could get a ride with you, Id be in your debt. I wanna go ... to the organ ... that will be my next host -- CHORUS: Take me to the liver; keep me out of water. Take me to the liver; keep me out of water. I dont know why this guys diets so bad; think of all the healthy food he could have had. But its my chips and cheesecake hes been ingestin, and, next thing I know, Im in the intestine. I wanna go ... to a gland: ... the one that weighs the most -- CHORUS Bind me, squeeze me, transport me, then release me. But I cant. Yes you can. No I cant. Yes you can. Yes you can, yes you can, yes you can.... (Yes I can!) Ill take you to the liver, and Ill keep you out of water. Yes, Ill take you to the liver, and Ill keep you out of water. Dont let me out yet, or Ill form a plaque; the last thing we need right now is a heart attack. Twenty-seven carbons there in my frame; am I the biggest lipid you can name? I wanna go ... to some cells ... where I'll be endocytosed -- CHORUS [twice] 10. Come On Down (The Electron Transport Chain) words and music by Greg Crowther and Sam Reid, 1999-2000 performed by Sam Reid, 2000 Electron pair on NADH, looking for a place to go -- You could jump onto pyruvate, but if you want to reach a lower energy state, Why dont you come on down the electron transport chain And take a downhill ride on this one-way train? Oh, wont you come on down the electron transport chain? It exploits (G to make ATP. Electron pair on FADH2 -- the Krebs cycles done with you. Though the matrix is your current home, you could be transferred to ubiquinone, And you could come on down the electron transport chain. The loss of one cytochrome is anothers gain, So wont you come on down the electron transport chain? It exploits (G to make ATP. You cant just hold on to the same old thing; why should you hold on to that nicotinamide ring, When you could come on down the electron transport chain, And take a downhill ride on this one-way train? Oh, wont you come on down the electron transport chain? It exploits (G to make ATP. Oh, wont you come on down the electron transport chain, And take a downhill ride on this one-way train? Oh, wont you come down the electron transport chain? It exploits (G to make ATP. Wont you come on down the electron transport chain? The loss of one cytochrome is anothers gain, So wont you come on down the electron transport chain? It exploits (G to make ATP. Oh, wont you come on down the electron transport chain.... 11. Erica words and music by Greg Crowther, 1999 performed by Joel Tetreault live at the Iguana Cafe (Rochester, NY), 2001 Well, I know the sequence of the steps in glycolysis, And I know how to catalyze an amide hydrolysis, And I know the first forty digits of the value of pi. I convert to Celsius without a thermometer, And I know know to calibrate a light spectrometer; I havent figured you out yet, but Id really like to try. CHORUS: Erica, Erica, Ive been across America, studying all the way through. But theres more to me than just esoterica -- theres lots of love for you. Now I know every bone from the toes to the cranium, And I know twenty-seven uses for uranium, And I know what the ideal gas equation is for. I can do PCR with help from Thermophilus, And I know the reproductive cycle of Drosophila, And I know youre in there, and I wish you would open the door. CHORUS Yes, I know the function of Wernickes area, And I know the tertiary symptoms of malaria, And I know who coined the term cell -- it was Robert Hooke. I know Newtons first and second Laws of Motion, And I know the osmolarity of every major ocean, But I don't know how to please you, so I guess Ill go back to my books. 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